Scarfe_A Malignant Hematology Cases Student Copy
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8/12/2019 Scarfe_A Malignant Hematology Cases Student Copy
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"
MED 525: Malignant Hematology SmallGroup Cases
StudentsVersion
Monday, May 5, 201
"#ti$ity 1: Generate a Summary .a/le o! te Hematologi#Malignan#ies
Mis#ellaneous
.reatment
1n$estigations
Complete 2loodCount3erip0eral2loodSmear
oneMarro
4
Splenomegaly
ympadenopaty
SymptomsandSigns
"eoplasms
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3at0ology
SeeMyeloproliferative
"#uteympo
/lasti#eu6emia
7on(Hodg6in5ymp0oma,lo
4
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Croni#Myelo
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MalignantHematologi#Disorder
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C0roni#5ymp0o#yti#5eu6emia
ympoproli!erati$e Myeloproli!erati$e7eoplasms7eopla
smsHodg6insDisease
MultipleMyeloma
Myelo!i/rosis
Myelodysplasia
"#uteMyeloid5eu6emia
MED 525: Malignant Hematology Small Group Cases Students Version
Monday, May 5, 201
"#ti$ity 2: Ma#ro#yti# "nemia 8Myelodysplasti# Syndrome and "#uteMyeloid eu6emia9
2ase material prepared by 4r. M.odnar
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earning /;e#ti$es:
1. ;rovide a differential diagnosis for macrocytic anemia.
2. 4escribe which aspects of a history, physical e
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3. /ecogni%e that myelodysplastic syndromes may present as cytopenias and can progress to acute leukemia.
4. =nderstand myelodysplastic syndromes and why a bone marrow e
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MED 525: Malignant Hematology Small Group Cases StudentsVersionMonday, May 5, 201
0his patient is diagnosed with myelodysplastic syndrome based on the morphologic findings of her bone marrowe
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#
MED 525: Malignant Hematology Small Group Cases Students Version
Monday, May 5, 201
"#ti$ity ): solated Cer$i#al ympadenopaty 8ympoproli!erati$e7eoplasms9 2ase material prepared by 4r. :. ;eters
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earning /;e#ti$es:
1. 4evelop an age-appropriate differential diagnosis for isolated cervical lymphadenopathy.
2. 4escribe which aspects of a history, physical e
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3. Elicit a history of >? symptoms using established criteria.
4. 4istinguish between diagnostic strategies &e.g.* fine needle aspiration, core biopsy, e
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showed lymphoma?
6. Were there any features in the initial history and physical examination that might have prompted a request for
an excisional lymph node biopsy instead of a fine needle aspiration biopsy?
MED 525: Malignant Hematology Small Group Cases Students Version
Monday, May 5, 201
"#ti$ity : eu6o#ytosis and Splenomegaly 8Myeloproli!erati$e7eoplasms9 2ase material prepared by 4r. M. odna
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earning /;e#ti$es:
1. /ecogni%e that non-hematologic and both malignant and benign hematologic disorders may present withsplenomegaly.
2. 4escribe which aspects of a history, physical e
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3. 4escribe the speciali%ed molecular testing available to help diagnose a myeloproliferative disorder and why it mightrepresent important targets for therapy.
4. 4istinguish between myelodysplastic syndrome &M41', myeloproliferative neoplasms, and myelofibrosis.
5. 4escribe when patients with leukocytosis andBor splenomegaly should be referred to a specialist for further work-upand management.
: si
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MED 525: Malignant Hematology Small Group Cases StudentsVersionMonday, May 5, 201
6. What features in this peripheral blood film have led the hematopathologist to suggest a myeloproliferative
disorder?
7. Which myeloproliferative neoplasm could it be?
8. ,he peripheral blood film displays -leukoerythroblastic features )characteri%ed by nucleated erythrocytes&
tear drop forms& and immature leukocytes*& normochromic normocytic anemia& and thrombocytopenia. Whatdoes this mean?
9. What special molecular diagnostic tests would you request if you think that this patient has a
myeloproliferative neoplasm?
0he internist arranges for the patient to have a bone marrow e
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