Rajesh Agarwal, Ph.D. - Denver, Colorado · 2014-07-07 · Rajesh Agarwal, Ph.D. 10 and skin...

Rajesh Agarwal, Ph.D.

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CURRICULUM VITAE Rajesh Agarwal, Ph.D.

Office address: Rajesh Agarwal, Ph.D. Professor, Department of Pharmaceutical Sciences Co-Leader, Cancer Prevention and Control Program University of Colorado Cancer Center University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences 12850 E. Montview Blvd, C238, Room V20-2118 Aurora, CO 80045 Office telephone number: (303) 724-4055 Office Fax number: (303) 724-7266 E-mail: [email protected]

Education 1975 B.Sc.: Chemistry, Botany, and Zoology - Lucknow University, India. 1976 B.Sc. (Hons.): Organic Chemistry - Lucknow University, India. 1977 M.Sc.: Organic Chemistry - Lucknow University, India. 1981 Ph.D.: Bioorganic Chemistry (Medicinal) - Lucknow University, India.

Academic Appointments 3/2001- Professor (7/04: Tenure), Department of Pharmaceutical Sciences, School

of Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado.

7/2009- Co-Program Leader, Cancer Prevention & Control, University of Colorado

Cancer Center. 7/2001- Graduate Faculty, Toxicology/Pharmaceutical Sciences, Department of

Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado.

1998- Full Member, University of Colorado Cancer Center, University of

Colorado Health Sciences Center, Denver, Colorado. 2000-2001 Senior Scientist (Professor), Center for Cancer Causation and Prevention,

AMC Cancer Research Center, Denver, Colorado.


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1998-2000 Scientist (Associate Professor), Center for Cancer Causation and Prevention, AMC Cancer Research Center, Denver, Colorado.

1992-1997 Assistant Professor, Department of Dermatology, Case Western Reserve

University, Cleveland, Ohio. 1995-1997 Assistant Professor, Division of General Medical Sciences (Oncology) and

CWRU Cancer Center, Case Western Reserve University, Cleveland, Ohio.

1991-1992 Senior Research Associate, Department of Dermatology, Case Western

Reserve University, Cleveland, Ohio. 1989-1991 Research Associate, Department of Dermatology, Case Western Reserve

University, Cleveland, Ohio. 1988-1989 Research Associate, Department of Pathology/Department of Biology,

Case Western Reserve University, Cleveland, Ohio. 1985-1988 Assistant Professor, Chemistry Department, Manipur University, Imphal,

India. 1983-1985 Research Associate/Scientist Pool, Industrial Toxicology Research

Center, Lucknow, India. 1978-1982 Junior/Senior/Post-Doctoral Research Fellow, Chemistry Department,

Lucknow University, Lucknow, India.

Research Interests • Cancer Biology: Oncogenes and tumor suppressor genes, cell cycle modulation,

p53, cyclins, cyclin dependent kinases, cyclin dependent kinase inhibitors (Cip 1/p21, Kip1/p27), apoptosis, and mitogenic and anti-apoptotic signaling pathways, transcription factors, cancer cell metabolism, miRNA.

• Cancer Pharmacology: Chemoprevention of cancer by natural and synthetic agents - cellular, biochemical and molecular mechanisms employing biochemical and molecular biological techniques. Evaluation of cancer chemopreventive potential of dietary constituents employing several long-term animal tumor bioassay protocols, and short-term animal and cell culture assays. Therapy of cancer by natural and synthetic agents - cell culture studies and nude mice xenograft models. Cancer models include skin, prostate, breast, lung, colon, bladder, pancreas, and head & neck.

• Warfare vesicants: Cutaneous and ocular injuries by vesicants, and rescue by natural and synthetic agents.


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Additional Professional Experience • Carcinogenesis - causation and mechanistic studies employing enzyme bioassay

and molecular biology approaches, cell culture technique and long-term animal tumor studies.

• Drug Metabolism - purification of cytochrome P450 1A1, and characterization by SDS-PAGE, Western blotting, peptide mapping and sequencing.

• Photodynamic therapy -in vivo and in vitro mechanisms of photodynamic effect of photosensitizers, specifically phthalocyanines, and evaluation of PDT effect of phthalocyanines in murine skin tumor models.

• Protein chemistry - isolation, characterization and structure determination of proteins by chemical modifications, photo cross-linking, HPLC, SDS-PAGE analysis, Western blotting, peptide analysis and N-terminal amino acid sequencing.

• Medicinal chemistry - synthesis of different heterocyclic nuclei like indoles, quinazolones, imidazolones, pyrazolones, thiazolidenes etc., their structural characterization and screening for CNS disorders and activity as anti-inflammatory agents. Isolation and characterization of phytochemicals as potential cancer preventive agents.

Consulting Activity

• Consultant with Indena, Italy, on developing silibinin for prostate cancer prevention and treatment in the patients, 2003.


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Teaching Activity 1. Undergraduate and Graduate Courses Pharm D Courses at SOP, UCHSC: Fall, 2001-2004 IOS X, PHRD 5710, Pharmacology of Antimicrobial

agents (P3). Fall, 2001 Instructional Methods II, PHRD 4200 (P1). Spring, 2002-2005 IOS I, PHRD 3750, Endocrine System (P1). Fall, 2002-2005 IOS IX, PHRD 5700, Endocrine Systems – Hormone

Regulation Review (P3), Co-instructor with Dr. Altiere. Spring, 2003-2005 PHRD 5860, Alternative Medicine Course. Spring, 2002-Present: IOS VI, PHRD 4750, Cancer Chemotherapy (P2).

Graduate Courses at DOPS, SOP, UCHSC:

Fall, 2002-2004 Course Coordinator, Topics in Toxicology Research. Fall, 2002-2005 Instructor, Experimental Methods in Toxicology. Spring, 2003 Instructor, Pharmacology Course/Natural Products

and Chemoprevention. Spring, 2005 Instructor, TXCL-PHSC 7530 Cancer: Experimental

and Medical Aspects, Cancer Chemoprevention. Spring, 2002-2006 Instructor, Principles of Toxicology II: Drug

Metabolism - Sulfate Conjugation & Acylation. Spring, 2006 Course Co-Director, Environmental and Target Organ

Toxicology, TXCL 7323 Fall, 2006 Course Director and Instructor, TXCL-PHSC 7400

Ethical Issues in Tox & Pharm Sci. Spring, 2002-2009 Instructor, Principles of Toxicology II: Heart &

Vascular. Fall, 2005-Present Instructor, Principles of Toxicology I, Cancer

Chemoprotection. Fall, 2005-Present: Instructor, Principles of Toxicology I, Signal

Transduction. Winter, 2005-Present Instructor, TXCL-PHSC 7400 Ethical Issues in Tox &

Pharm Sci. Winter, 2007-Present Instructor, TXCL-PHSC 7310 Cell Cycle

2. Continuing Education

Lectures and Seminars to Residents at Department of Dermatology, Case Western Reserve University, Clevelend, OH. 1993-1997. The format included: Journal Club, Lectures related to molecular biology and other laboratory techniques, and Laboratory Methods demonstration.


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Advising Activity Pharm D. Advisor to Todd Allen and Julie Ball, P3 students, for their seminar presentation on Complementary and Alternative Therapies for Cancer Treatment, December 2002. Advisor to Ylan Cao and Kiesha Van Valkenburgh, P3 students, for their seminar presentation on Epidermal Growth Factor Receptor: A molecular target for epithelial cancer prevention and therapy, April, 2004. Advisor to Vanessa Rogers and Jennifer Trask, P3 students, for seminar presentation on Nutritional supplements: good or bad for cancer patients, November, 2006. Advisor to Ajay Gupta and Galina B Yermilova, P3 students, for seminar presentation on Nutritional supplements: good or bad for cancer patients, September, 2007. Advisor to Angela Luetters and Raymond Pechek, P3 students, for seminar presentation on Nutritional supplements: good or bad for cancer patients, September, 2008. Advisor to Quynh Lai and Jennifer Schwab, P3 students, for seminar presentation on Nutritional supplements: good or bad for cancer patients, October, 2009. Advisor to Gbemileke K Renner and Janet Liang, P3 students, for seminar presentation on Nutritional supplements: good or bad for cancer patients, Academic year 2010. Advisor to Amy Amerine and Sarah Caravella, P3 students, for seminar presentation on Nutritional supplements: good or bad for cancer patients, Academic year 2011. Advisor to Atit Patel and Dean Sun, P3 students, for seminar presentation on Nutritional supplements: good or bad for cancer patients, Academic year 2012. Advisor to Jennifer Iverson and Jung (Janet) Oh, P3 students, for seminar presentation on Nutritional supplements: good or bad for cancer patients, Academic year 2013.


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Advising Activity Ph.D. Students

• Srirupa Roy, Molecular Toxicology Graduate Program, DOPS, 2003-2008; graduated on April 4th, 2008. Currently Research Associate at UCSF.

• Samiha M. Mateen, Molecular Toxicology Graduate Program, DOPS, 2007-2012; graduated on April 27th, 2012. Currently Research Scientist at a Biotech Company in CA.

• Sangeeta Shrotriya, Molecular Toxicology Graduate Program, DOPS, 2008-2013; graduated on April 5th, 2013. Post Doc. Fellow, UCD AMC Stem Cell Research Center.

• Swetha Ituri, Molecular Toxicology Graduate Program, DOPS, 2008-2013; graduated on April 24th, 2013. Post Doc. Fellow, , DOPS, UCD, Denver.

• Molly M Derry, Molecular Toxicology Graduate Program, DOPS, 2009-2013; graduated on June 14th, 2013. Post Doc. Fellow, Natioanl Jewish, Denver.

• Cynthia Tilley, Molecular Toxicology Graduate Program, DOPS (2011-). • Harold Ting, Pharmaceutical Sciences Graduate Program, DOPS (2011-). • Ankita Nagvekar, Pharmaceutical Sciences Graduate Program, DOPS (2014-).

Graduate Students Rotations – UCHSC, DOPS Heather Walczak (2002) Srirupa Roy (2002) Heather Leitner (2003) Samiha M. Mateen (2007) Sangeeta Shrotriya (2007) Swetha Ituri (2008) Molly M Derry (2009) Cynthia Tilley (2010) Harold Ting (2011) Amandla Roque-Atilano (2012-2013) Deepanshi Dhar (2013-2014) Graduate Students (Ph.D.) Committees – UCHSC, DOPS Member on Charles Hughes (M.S. Defense Committee, graduated 2002) Member on Jeanmarie Zodrow (graduated 2003) Member on Katherine Peebles (graduated 2005) Member on Mark Reimers (2001-2005, graduated 2005) Chair on David Carbone (2001-2005, graduated 2005) Chair on Brante Sampey (2001-2005, graduated 2005) Chair on Ileana Vargas (2001-2005, graduated with Masters, 2005) Member on Heather Walczak (2002-2007, graduated 2007) Member on Elizabeth Redente (2003-2008, graduated 2008) Chair on James R. Roede (2006-2009, graduated May 2009) Chair on Rebecca Echols (2008-2009) Chair on Jason Fritz (2007-2011, graduated March 2011) Member on Yan Chao (2007-2011, graduated March 2011) Chair on William J. Black (2010-2011, graduated March 2011)


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Member on Gaurav Mehta (2008-2011, graduated with Masters, 2011) Chair on Chuan-Hsin (Cindy) Chang (2012-) Member on Ross Osgood (2013-)


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Advising Activity Undergraduate Students Name Title of Research Project Training Period Galvin, Brea Phytochemicals and skin cancer. 2003 Haque, A. Search for potential cancer chemo- 1993-1995 preventive agents. Julka, K. Epidermal growth factor receptor 1996 and cancer prevention by silymarin. Kale, S. Phytochemicals and Prostate Cancer 2000 Prevention. Kaur, Gurupreet Pancreatic cancer prevention 2010 Kapoor, Ruchi Phytochemicals and prostate cancer. 2003 Khatter, Sonia Phytochemicals and prostate cancer 2008, 2010 Krishnamurthi, R. Evaluation of antioxidant potential 1994-1995 of silymarin. Liem, V.K. Ha-Ras oncogene and skin cancer. 1993 Pawar, Shagun GSE and H&N cancer 2007-2009 Sathi, Kunji Phytochemicals and prostate cancer. 2003 Sequeira, Sabina Flavonoids and bladder cancer. 2003 Sharma, Kapil Phytochemicals and Prostate cancer 2001 Sikka, A H&N cancer prevention. 2010 Sinha, Arjun Prostate cancer therapeutic agents. 2006


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Advising Activity Postdoctoral Fellows/ Faculties Name Title of Research Project Training Period Current Position Ahmad, N., Ph.D. Cell cycle control and apoptosis 1996 to 1998 Professor, in skin cancer therapy Univ of Madison Balaiya, Vel, Ph.D. CRC and Phytochemicals 2007-2009 Post-doc Bhatia, N., Ph.D. Signal transduction, cell cycle 1998-2000 Post-doc regulation and prostate cancer Broussard, Alton Laboratory Manager 2005- PRA (current) Chittezhath, M, Ph.D. Silibinin and lung cancer prevention 2004-2005 Res. Scientist, Singapore Deep, Gagan, Ph.D. Flavolignan and cancer prevention 2004- Res. Assist. Prof. (current) Dhanalakshmi, S., Ph.D. Cancer Prevention via targetting cell 2000-2004 Res. Scientist, Biotech, survival signaling. India. Dhar, D., M.S. Mustard and skin toxicity 2012- PRA (current) Flaig, Thomas, M.D. Silibinin and prostate cancer 2005-2008 Associate Professor Oncology Div, UCDAMC Gali, H., Ph.D. Epidermal growth factor receptor 1996 Professor, Lebanon and cancer prevention by silymarin Gangar, S., Ph.D. Silibinin and prostate cancer 2008-2010 Post-doc Goswami, D., Ph.D. Mustard and ocular toxicity 2013- Post-doc (current) Guillermo, R., Ph.D. Silibinin and skin cancer 2012- Post-doc (current) Javed, S., Ph.D. Mechanism of skin chemical 1993, 1996 Science Writer, India carcinogenesis Jain, A., Ph.D. Sulfur mustard skin toxicity 2009- Post-doc (current) Katiyar, S.K., Ph.D. Skin cancer chemoprevention: 1992-1995 Professor, mechanism and long-term tumor studies Univ of Alabama Kaul, Nidhi, M.D. GSE and cancer prevention 2006-2007 Physician, Internal Medicine, NY Kaur, M., Ph.D. Silibinin and lung cancer prevention 2003-2012 Res. Assoc. Dermatology, UCD Khan, S.G., Ph.D. Ras oncogene, farnesyltransferase 1992-1995 Tenured Scientist,


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and skin carcinogenesis NCI/NIH, Intramural Kuhn, C., M.D. Metabolism of chemical carcinogens 1992-1993 Private Practice, in mouse and human epidermal cells. Dermatology, USA Kumar, D., Ph.D. Mustard and skin toxicity 2013- Post-doc (current) Kumar, R., Ph.D. Phytochemicals and prostate cancer 2013- Post-doc (current) Kumar, S., Ph.D. Silibinin and colorectal cancer 2010- Post-doc (current) Lahiri, M., Ph.D. Photocarcinogenesis and skin cancer 1995-1996 Biotech Sales Rep, Chemoprevention India Mallikarjuna, GU, Ph.D. Skin cancer prevention by silibinin. 2002-2011 Res. Assoc. Mohan, R.R., Ph.D. Ras p21 processing, retinoids and skin 1993-1995 Professor, tumor progression. Univ. of MO Mohan, S., Ph.D. Silibinin and skin cancer prevention 2003-2005 Post-doc, Univ South Carolina Pal, Arttatrana, Ph.D. CEES toxicity and Rescue 2007-2009 Assistant Professor KIIT University, India Rajamanickam, S., Ph.D. CRC and Phytochemicals 2007-2009 Post-doc, UTHSC, San Antonio, TX Raina, Komal, Ph.D. Silibinin efficacy in epithelial cancer 2005- Res. Instructor (current) Ramasamy, K., Ph.D. Silibinin and lung cancer 2007-2010 Post-doc, UTHSC, San Antonio, TX Rana, Sumeet, M.Phil. CEES toxicity and Rescue 2006-2008 PRA at Biotech, Boulder, CO Ravichandran, K., Ph.D. Silibinin and lung cancer 2007-2009 Res. Associate, UCD Sharma, Girish, Ph.D. Grape seed extract and breast cancer 2001-2003 Professor, Amity University, India Sharma, Y., Ph.D. Mechanism of silymarin’s anti- 1998-2000, Professor & Chairman, carcinogenic activity in prostate cancer 2007 Lucknow Univ., India Sreekanth, C.N., Ph.D. Silibinin and skin cancer 2010-2012 Post-doc, Univ MN Shreshta, S., Ph.D. GSE and prostate cancer 2008-2010 Res. Scientist, Biotech Singh, Rana P., Ph.D. Skin cancer prevention by silibinin 2000-2006 Professor and Dean Central University of Gujarat, India


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Somasagara, R., Ph.D. Phytochemicals and colorectal cancer 2012- Post-doc (current) Tewari-Singh, N., Ph.D. CEES toxicity and Rescue 2006- Res. Instructor (current) Tyagi, Alpana, Ph.D. Phytic acid and prostate cancer: role 1999- Res. Assoc. (current) of receptor endocytosis Tyagi, Anil, Ph.D. Phytochemicals and Cancer Prevention: 2000-2004 Not known Identification of active compounds Varghese, Leyon, Ph.D. Phytoprevention of angiogenesis 2004-2005 Res. Assoc., Singapore University Vijendra, Kavitha, Ph.D. Silibinin and prostate cancer 2010-2011 Assistant Professor Karnatak College, India Wadhwa, R., B.S. IP6 and prostate cancer 2010-2012 Medical Student, AZ Zhao, J., Ph.D. Phytochemicals and skin cancer 1998-2000 Scientist, Biotech Co. Prevention Zi, X., MD, Ph.D. Signal transduction & cell cycle 1996 to 1998 Associate Prof., regulation in cancer prevention Univ of California, Irwin


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Administrative Activity and University Service • Member, Core Curriculum Committee, Department of Dermatology, CWRU,

1994-1997. • Member, Academic Computer Committee, Department of Dermatology, CWRU,

1996-1998. • Chair, Budget Sub-committee for Academic Computer Committee, Department of

Dermatology, CWRU, 1996-1998. • Member, Safety Committee, AMC Cancer Center, Denver, CO, 1998-1999. • Member, Biohazard Committee, AMC Cancer Center, Denver, CO, 1999-2000. • Member, ASPA Committee, AMC Cancer Research Center, Denver, CO, 2000-

2001. • Chair, Sunscreen Certification Committee of ASPA, AMC Cancer Research

Center, Denver, CO, 2000-2001. At University of Colorado Denver

• Chair, Toxicology Graduate Program Admission Committee, DOPS, SOP, 2001- • Member, Space Committee, SOP, 2002-2004. • Member, Search Committee, Basic Science/Prostate Cancer Faculty Candidate,

Univ. Colorado Cancer Center, UCHSC, 2002. • Chair, Student Admission and Affairs Sub-committee, Toxicology Graduate

Program, DOPS, SOP, 2002- • Member, Curriculum Sub-committee, Toxicology Graduate Program, DOPS,

SOP, 2002. • Co-Organizer, Seminar Series for Toxicology Graduate Program, DOPS, 2002-

2003. • Co-Organizer, Journal Club for Toxicology Graduate Program, DOPS, 2002-

2003. • Organizer, Seminar Series for Toxicology Graduate Program, DOPS, 2003-2004. • Organizer, Journal Club for Toxicology Graduate Program, DOPS, 2003-2004. • Member, Post-doctoral Task Force, UCHSC, represented SOP, DOPS, 2003. • Member, Molecular Toxicology Faculty Search Committee, DOPS, SOP, 2002-

2003. • Member, DOPS Research Committee, 2003-2007. • Member, DOPS Appointment, Promotion and Tenure Committee, 2004-2006;

2006-2008; 2008-2010. • Chair, DOPS Appointment, Promotion and Tenure Committee, 2005-2006. • Member, Building Committee, Pharmaceutical Research Center of the Skaggs

School of Pharmacy and Pharmaceutical Sciences, 2007-2010. • Chair, Search Committee for PK/PD Faculty Position, DOPS, SOP, UCHSC,

2007. • Member, Search Committee for Neurosciences Faculty Position, DOPS, SOP,

UCHSC, 2008. • Chair, DOPS Appointment, Promotion and Tenure Committee, 2008-2009. • Chair, DOPS Research Committee, 2008-


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• Co-Program Leader, Cancer Prevention & Control, University of Colorado Cancer Center, 2009-

• Member, Vice Chancellor for Academic Affairs, University of Colorado Denver Appointment, Promotion and Tenure Committee, 2011-

• Member, Scholastic Advancement and Appeal Committee, School of Pharmacy, University of Colorado Denver, 2012-

• Member, Mission, planning and evaluation committee, ACPE Accreditation 2015, School of Pharmacy, University of Colorado Denver, 2013-


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Professional Activity and Public Service Membership in Professional Organizations

• Member, Society for Investigative Dermatology, USA (upto 2000). • Member, American Association for Cancer Research. • Member, American Association for the Advancement of Science. • Member, American Society for Photobiology. • Member, Society of Toxicology.

Grant Review Panels

• Research Advisory Group Proposals from Veterans Administration, Washington DC, 1994-1995.

• Merit Review Proposals from Veterans Administration, Washington DC, 1994-1995.

• Member, Special Emphasis Panel on Cancer Chemoprevention, National Cancer Institute, NIH, Bethesda, MD, 1997-1998.

• Member, NIH/NCRR Site Visit Team to the Florida International University Res. Ctr. in Minority Inst Program, March, 1999.

• Ad-hoc Member, Metabolic Pathology Study Section, NCI, NIH, March 13-15, 2000.

• Ad-hoc Member, Metabolic Pathology Study Section, NCI, NIH, June 26-28, 2000.

• Member, NCI/NIH Site Visit Team for Program Project on “Inhibition of Carcinogenesis by Tea and Tea Constituents”, Rutgers University, May 17-19, 2000.

• Chairman, NCI/NIH Special Emphasis Panel, ZRG1 CONC (02)M, July 19, 2000. • Member, NCI/NIH Special Emphasis Panel, ZRG1 ET-2 03, December 12, 2000. • Member, NCI/NIH Teleconference Review Panel for Program Project on

“Inhibition of Carcinogenesis by Tea and Tea Constituents”, Rutgers University, January 11, 2001.

• Ad-hoc Member, Chemical Pathology Study Section, NCI, NIH, January 17-19, 2001.

• Ad-hoc Member, Chemical Pathology Study Section, NCI, NIH, June 11-13, 2001.

• Ad-hoc Member, Subcommittee-Cancer Epidemiology, Prevention and Control Study Section, NCI, NIH, April 4-6, 2001.

• Member, California Breast Cancer Research Program (Innovative Treatments) Review Committee, CA, April 20-21, 2001.

• Member (mail reviewer), Ohio Cancer Research Associates Grant Review, Columbus, OH, May-June, 2001.

• Member (mail reviewer), Special Emphasis Panel, Evaluation of Chemopreventive Agents by In Vivo Screening, NCI, NIH, June, 2001.

• Member, NIEHS Special Emphasis Panel, ZES1 BKW-C (RO), NIH, July 15-18, 2001.


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• Member/Reviewer (by Mail), Biomedical Research Council, Singapore, July 2001.

• Member, NCI Special Emphasis Panel, ZRG1 CPA-02, October 11, 2001. • Member, NCI Special Review Committee Meeting, ZRG1 PTHB 01 M, November

7, 2001. • Member, California Breast Cancer Research Program (Innovative Treatments)

Review Committee, CA, April 27-29, 2002 • Special Reviewer (by mail), U.S. Civilian Research and Development

Foundation, June 2002. • Member/Reviewer (by Mail), Biomedical Research Council, Singapore, July

2002. • Member, NCI Special Emphasis Panel, ZCA1 SRRB-Q (J1) Cooperative Grants

for Nutritional Modulation of Genetic Pathways Leading to Cancer, November 6-8, 2002.

• Member, California Breast Cancer Research Program (Innovative Treatments) Review Committee, CA, March 29-31, 2003.

• Ad-hoc Member, Subcommittee-Cancer Epidemiology, Prevention and Control Study Section, NCI, NIH, July 29-30, 2003.

• Member, NCI/NIH Teleconference Review Panel for Supplement to Program Project on “Inhibition of Carcinogenesis by Tea and Tea Constituents”, Rutgers University, February 18, 2004.

• Member, NCI Special Emphasis Panel ZCA1 SRRB-Y (M1), Developmental/Pilot Projects in Cancer Complementary and Alternative Medicine, March 8-10, 2004.

• Member, European Science Foundation Exploratory Workshop Review Pannel, France, 2004.

• Reviewer, Pilot Project Program, Center for Research on Environmental Disease, UT MD Anderson Cancer Center, Science Park Division, Texas, 2004.

• Reviewer, Biomedical Research Council Research Proposals, Singapore, 2004. • Member, NCI Special Review Committee Meetings (teleconference reviews),

3/11/2002, 6/28/2002, 7/18/2002, 11/14/2002, 11/19/2002, 4/1/2003, 7/9/2003, 7/24/2003, 11/17/2003, 4/7/2004, 4/12/2005, 7/26/2005, 11/1/2005, 5/25/2006, 10/30/06, 6/23/2008, 9/30/2008.

• Regular Member, Cancer Etiology (formerly Chemical Pathology) Study Section, NCI, NIH, October, 2001 to June, 2005.

• Member, Review Panel RFA-A1-04-045, Centers for Countermeasaures against Radiation, ZCA1 SRRB-E (01), June 20-22, 2005.

• Mail Reviewer, University of Kansas, Center for Cancer Experimental Therapeutics, Center of Biomedical Research Excellence (COBRE), NIH, grant review, September, 2005.

• Mail Reviewer, Research Management Group, Philip Morris External Research Program, November, 2005.

• Ad-hoc Member, Cancer Etiology Study Section, NCI, NIH, February 13-15, 2006; June 19-20, 2006; October 16-17, 2006; February 12-13, 2007; June 11-12, 2007; Feb 11-12, 2008; Feb 9-10, 2009.


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• Member, California Breast Cancer Research Program (Innovative Treatments) Review Committee, CA, March, 2006, 2007, 2008, 2009.

• Member of the Review Committee Site Visit Team, NCI, IRG Subcommittee A (Cancer Centers P30 Program), Moffitt Cancer Center, University of South Florida, Tempa, FL. June12-14, 2006.

• Member, Peer Review Panel, DOD-Prostate Cancer Research Program, Exploration: Hypothesis Development #3, May-june, 2006.

• Member, Teleconference Peer Review Panel, University of Connecticut, Center for Health, Intervention and Prevention Seed Grants Program, August 4th, 2006.

• Member, American Institute for Cancer Research (Panel 1, Prevention Research) Review Committee, Washington DC, March, 2007; August, 2007; March, 2008, May 2009.

• Member, NCCAM SEP ZAT1 SM-07 Review Committee for Centers of Excellence for Research on Complementary and Alternative Medicine (CERC), Bethesda, MD, June 20th to 22nd, 2007, June 25th to 27th, 2008.

• Member On-site Visit Team, Austria Government Cancer Center Program, Vienna, Austria, September 20th, 2007.

• Mail Reviewer, French National Cancer Institute Grant Review Panel, September 17, 2007.

• Ad-hoc Member, Chemo and Dietary Prevention Study Section, NCI, NIH, October 4-5, 2007, June 11-13, 2008.

• Member, CTSI-K12 Review Committee, University of Colorado Denver, September 12, 2008.

• Member of the Review Committee Site Visit Team, NCI, IRG Subcommittee A (Cancer Centers P30 Program), Arizona Cancer Center, University of Arizona, Tucsan, AZ. Feb18-20, 2009.

• Member, NCAAM PK-05 Basic Science Review Committee Special Emphasis Panel Grant Review, March 2009, June 2009.

• Member, NCAAM Teleconference Special Emphasis Panel ARRA SEP ZAT1 SM 15 P Grant Review, July 16th, 2009.

• Member Online Challenge Grants Panel 10 ZRG1 OTC-K (58) R Grant Review, July 20th-21st, 2009.

• Member, Cancer biology ARRA CR ZRG1 OBT-M (6) S teleconference Special Emphasis Panel Grant Review, July 23rd-24th, 2009.

• Member, NCCAM ZAT1 SM (14) Review Committee for Botanical Centers, Bethesda, MD, August 2nd-3rd, 2009.

• Online Grant Reviewer, Czech Science Foundation, September, 2009. • Member, ZRR1 RI-B (01) Review Committee for National Centers for Research

Resources, Bethesda, MD, September 22nd-23rd, 2009. • NCI PO1, 1-3 March, 2010 • NCCAM/NCI Bot Center, 3-5 March, 2010 • NCCAM R21, 8-9 March, 2010 • NCI EUREKA, 29-30 March, 2010 • CA Tobacco Lung Cancer Program, 8-9 April, 2010 • AICR, 13-14 May, 2010.


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• SDSU Advisory Committee, 12-13 June, 2010 • NCI K awards, 21-22 Sep, 2010 • Penn State Cancer Center Site visit, 28-30 September, 2010. • CA Tobacco Lung Cancer Program, March 14, 2011 • NCI EUREKA, 27-29 March, 2011 • NCI PO1, 22-25, 2011 • AICR, 3-5 August, 2011 • SDSU Advisory Committee, 16-17 September, 2011 • Member ZES1 LWJ-J DI 2 NIEHS R21 review committee, October 24-25, 2011 • Member, Cancer Prevention Research Small Grant Program (R03) NCI review,

October, 2011 • Member ZAT1 SM 25 review committee, NCCAM/R01, March 1-2, 2012 • CA Tobacco Lung Cancer Program, March 8, 2012 • SDSU Advisory Committee, February and September, 2012 • Cancer Prevention Research Small Grant Program (R03) NCI review, April,

June, October 2012 • Member Molecular Oncology Study Section, NCI, October 25-26, 2012. • Member, NCCAM SEP ZAT1 SM-28 CERC (P01) Review Committee, January

16-18, 2013. • SDSU Advisory Committee, February 2013. • Member ZRG1 MOSS-T (02) NIH R01 review committee, April 30, 2013. • Member Special Emphasis Panel/Scientific Review Group 2013/08 ZCA1 PCRB-

A (A1) S meeting, May 2013. • Member, Cancer Prevention Research Small Grant Program (R03) NCI review,

July 2013. • Member, ZAT1 HS14 Training, Education and AREA grants review, NCCAM,

October 2013. • Member, Lombardi Comprehensive Cancer Center support grant site visit team,

Georgetown University, December 2013. Journal Referee

• AAPS Journal • Acta Pharmacologica Sinica • Anti-Cancer Agents in Medicinal Chemistry • Antioxidant and Redox Signaling • Biochemical Pharmacology • Biochimie • Brain Research • Breast Cancer Research • Cancer Causes and Control • Cancer Chemotherapy and Pharmacology • Cancer Epidemiology, Biomarkers and Prevention • Cancer Letters • Cancer Research


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• Carcinogenesis • Cell Biology and Toxicology • Chemico-Biological Interactions • Chemotherapy • Clinical Cancer Research • Comparative Biochemistry and Physiology • Current Cancer Drug Targets • Current Medicinal Chemistry • European Journal of Cancer • European J. of Cell Biology • Experimental Biology and Medicine • Expert Review of Anticancer Therapy-Future Drugs • FEBS Letters • Food and Chemical Toxicology • Free Radical Biology and Medicine • Gastroenterology • International Journal of Cancer • International Journal of Oncology • International Journal of Radiation Biology • Journal of Biological Chemistry • Journal of Cellular Physiology • Journal of Dental Research • Journal of Dermatological Science • Journal of the National Cancer Institute • Journal of Pharmaceutical Sciences • Kidney International • Life Sciences • Lipids • Medical Research Reviews • Molecular Cancer Research • Molecular Cancer Therapeutics • Molecular Carcinogenesis • Molecular Nutrition and Food Research • Molecular Pharmacology • Mutation Research • Neoplasia • Nucleic Acids Research • Nutrition and Cancer • Oncogene • Oncotarget • Pharmaceutical Research • Photochemistry and Photobiology • PLOS ONE • PNAS, USA


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• Proceeding Indian National Science Academy • Skin Pharmacology • The International Journal of Biochemistry • The Journal of Investigative Dermatology • Toxicology and Applied Pharmacology • Toxicology Letters • Trends in Pharmacological Sciences • Urology

Editorial Board Member, Editorial Board of Skin Pharmacology, 1995-2000. Member, NCI PDQ Complementary and Alternative Medicine in Cancer Treatment (CAM) Editorial Advisory Board, 2005. Associate Editor, Cancer Research, 2/2008-12/2009. Member, Editorial Board, Cancer Prevention Research, 1/2008- Associate Editor, Molecular Carcinogenesis, 2/2008- Member, Editorial Board, Molecular Cancer Therapeutics, 2005- Senior Editor, BMC Complementary and Alternative Medicine (2011-2012) Member, Editorial Board, Clinical Medicine Insights: Oncology, 2007- Member, Editorial Board, International Journal in Medical Engineering and Informatics, 2007- Member, Editorial Board, Clinical Medicine Insights: Urology, 2007- Member, Editorial Board, Clinical Medicine Insights: Dermatology, 2007- Honorary Member, Editorial Board, Clinical, Cosmetic and Investigational Dermatology, 3/2008- Honorary Member, Editorial Board, Clinical, Pharmacology: Advances and Applications, 3/2009- Honorary Member, Editorial Board, Nutrition and Dietary Supplements, 3/2009- Honorary Editorial Board Invitation - Journal of Experimental Pharmacology, 5/2009- Section Editor, Basic Sciences, BMC Complementary and Alternative Medicine, 5/2011-1/2012 Academic Editor, PLOS ONE, 4/2013- Associate Editor, Curr Cancer Drug Targets, December, 2013-


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Invited Speaker, Honors and Awards • Invited Speaker talk entitled “Colon cancer chemoprevention by silibinin: targeting

the initiators and the initiated ones, a cancer stem cell perspective” at “2014 Cancer Prevention and chemoprevention symposium State of the Art” hosted by The University of Alabama at Birmingham Comprehensive Cancer Center and UAB SDRC,March 27th, 2014, Birmingham, Alabama.

• Prof. Rao Memorial Lecture entitled “Silibinin: The Magic of Multiple Mechanisms and Targets in Cancer Chemoprevention” at the School of Life Sciences, CUG, December 23rd, 2013, Gandhinagar, India.

• Session Chair entitled “Novel targets in chemoprevention of cancer” at the International Conference on “Recent Advances in Cancer Prevention and Therapeutics” at the School of Life Sciences, CUG, November 19-20, 2013, Gandhinagar, India.

• Keynote address entitled “Colon cancer chemoprevention by silibinin in the new era: targeting the initiators and the initiated ones, a cancer stem cell perspective” at the International Conference on “Recent Advances in Cancer Prevention and Therapeutics” at the School of Life Sciences, CUG, November 19-20, 2013, Gandhinagar, India.

• Organizing Chair and International Scientific Advisory Committee Member of the International Conference on “Recent Advances in Cancer Prevention and Therapeutics” at the School of Life Sciences, CUG, November 19-20, 2013, Gandhinagar, India.

• Session Chair entitled “Biomarkers and Early Detection of Cancer” at the International Symposium on Frontiers in Cancer Research: Prevention to Therapeutics, November 15-16, 2013, Amity University, Noida, India.

• Invited lecture entitled “Silibinin efficacy in non-melanoma skin cancer” at the International Symposium on Frontiers in Cancer Research: Prevention to Therapeutics, November 15-16, 2013, Amity University, Noida, India.

• Co-organizer, International Symposium on Frontiers in Cancer Research: Prevention to Therapeutics, November 15-16, 2013, Amity University, Noida, India.

• Inaugural address entitled “Synthetic organic chemistry to cancer chemoprevention: 30 years journey of a Lucknow University Graduate” at the Zoology Department, Lucknow University on National Education Day to commemorate Maulana Abul Kalam Azad, November 12th, 2013, Lucknow, India.

• Invited Speaker talk entitled “Silibinin and prostate cancer prevention” at 6th International Conference on Polyphenols and Health, October 16-19, 2013, Buenos Aires, Argentina.

• Invited Speaker talk entitled “Strategies to control prostate cancer by chemoprevention approaches” at 3rd International Conference of the International Association of Medical and Biological Researchers: Cancer – Present and Future Perspective, September 16-18, 2013, Mauritius.

• Invited Speaker talk entitled “Targeting Molecular Pathways in Tumor Microenvironment: A Holistic Approach for Prostate Cancer Chemoprevention by Silibinin” at Pharmaceutical Sciences Graduate Student Association/PSGSA-AAPS


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Annual Seminar Series, University of Missouri at Kansas City, March 21, 2013, Kansas City, MO.

• Invited Speaker talk entitled “Molecular Mechanism and Efficacy of Grape-derived Phytochemicals against Head and Neck Cancer” at NYU College of Dentistry Department of Basic Sciences and Craniofacial Biology, February 7th, 2013, New York, NY.

• Invited Speaker talk entitled “Silibinin ‘the double edged sword’: targeting both the initiators and the initiated ones in colon cancer” at the 3rd International Cancer Research Symposium: Defining & Translating Science for Disease Prevention and Therapy, December 18-21, 2012, Kolkata, India.

• Co-organizer, the 3rd International Cancer Research Symposium: Defining & Translating Science for Disease Prevention and Therapy, December 18-21, 2012, Kolkata, India.

• Invited Speaker talk entitled “Targeting Molecular Pathways in the Tumor Microenvironment: A holistic Approach for Cancer Chemoprevention” at the 11th Annual AACR international Conference on Frontiers in Cancer Prevention Research, October 16-19, 2012, Anaheim, CA.

• Plenary Speaker talk entitled “Frequently consumed dietary supplement milk thistle extract: from anti-hepatotoxicity to anti-prostate cancer efficacy in humans” at the 9th International Conference of the Society for Integrative Oncology, October 8-10, 2012, Albuquerque, NM.

• Invited Speaker Talk entitled “Tumor microenvironment as a novel druggable target by silibinin: promise and potential for a translational cancer chemopreventive strategy” at 2012 CRI Cancer Symposium: Innovative Approaches to Explore Novel Druggable Targets, May 16-19, 2012, Seoul National University, Seoul, S. Korea.

• Invited Speaker Talk entitled “Targeting tumor microenvironment with silibinin: promise and potential for a translational strategy in prostate cancer chemoprevention” at Feist-Weiller Cancer Center, LSU Health Sciences Center, April 17, 2012, Shreveport, LA.

• Session Speaker talk entitled “Targeting tumor microenvironment with silibinin: promise and potential for a translational cancer chemopreventive strategy” at the 4th International Conference on Drug Discovery & Therapy, February 12-15, 2012, Dubai, UAE.

• Co-chair, Mechanisms of Cancer Chemopreventive Agents, International Symposium on Recent Advances in Cancer Research: Therapeutics to Chemoprevention, February 8-9, 2012, Central University of Gujarat, Ahmedabad, India.

• Invited Speaker talk entitled “Targeting tumor microenvironment with silibinin: promise and potential for a translational prostate cancer chemopreventive strategy” at the International Symposium on Recent Advances in Cancer Research: Therapeutics to Chemoprevention, February 8-9, 2012, Central University of Gujarat, Ahmedabad, India.

• Co-organizer, International Symposium on Recent Advances in Cancer Research: Therapeutics to Chemoprevention, February 8-9, 2012, Central University of Gujarat, Ahmedabad, India.


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• Invited Speaker talk entitled “Inositol Hexaphosphate and Prostate Cancer: Efficacy and Mechanism” at the Fourth International Symposium on Translational Cancer Research Cancer Prevention, December 16-19, 2011, Udaipur, India.

• Invited Speaker talk entitled “Frequently consumed dietary supplement milk thistle extract: from anti-hepatotoxicity to anti-prostate cancer efficacy in humans” at the Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, October 7th, 2011, Columbia, SC.

• Invited Speaker talk entitled ““Prostate cancer efficacy of silybin and its structurally related flavonolignans” at the Chemistry/Biochemistry Department, University of North Carolina at Greensboro, September 9th, 2011, Greensboro, NC.

• Distinguished Invited Speaker talk entitled “Targeting tumor microenvironment with silibinin: promise and potential for a translational cancer chemoprevention strategy” at the Department of Biomedical Sciences, TTUHSC School of Pharmacy, September 2nd, 2011, Amarillo, TX.

• Visiting Professor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Peking Union Medical College, August 26-27, Beijing, China.

• Vive Chairperson, Scientific Advisory Committee, International Meeting on Natural Products and Cancer Targets: Progress and Promise, August 24-25, 2011, Zhengzhou, China.

• Concluding Remarks and Summary of the Meeting at the International Meeting on Natural Products and Cancer Targets: Progress and Promise, August 24-25, 2011, Zhengzhou, China.

• Invited Speaker Talk entitled “Targeting Tumor Microenvironment with Silibinin: Promise and Potential for a Translational Cancer Chemopreventive Strategy” at the International Meeting on Natural Products and Cancer Targets: Progress and Promise, August 24-25, 2011, Zhengzhou, China.

• Invited Speaker Talk entitled “Inositol Hexaphosphate and Prostate Cancer: Efficacy and Mechanism” at the 3rd China-US Forum on Frontiers of Cancer Research and 1st International Symposium on Stem Cell and Regenerative Medicine Conference, August 20-23, 2011, Zhengzhou, China.

• Invited talk entitled “Develop CEES-induced skin toxicity models, and evaluate silibinin efficacy” at 5th Annual NIH CounterACT Network Research Symposium, June 2011, Washington DC.

• Invited Speaker talk entitled “Chemopreventive Efficacy of Inositol Hexaphosphate in Prostate Cancer” at the Hormone-related Malignancies Retreat, University of Colorado Cancer Center, March 25th, 2011.

• Invited Speaker talk entitled ““Silibinin Efficacy in Prostate Cancer: Bench to Bedside” at the Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, March 18, 2011, Piscataway, NJ.

• Inaugural Speaker talk entitled “Inositol Hexaphosphate efficacy in prostate cancer” at the International Conference on Recent Advances in Cancer Research: Bench to Bedside, February 19-20, 2011, Ahmedabad, India.

• Co-chair, Novel agents and targets in cancer control, International Conference on Recent Advances in Cancer Research: Bench to Bedside, February 19-20, 2011, Ahmedabad, India.


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• Co-chair, Inaugural Session, International Conference on Recent Advances in Cancer Research: Bench to Bedside, February 19-20, 2011, Ahmedabad, India.

• Co-organizer, International Conference on Recent Advances in Cancer Research: Bench to Bedside, February 19-20, 2011, Ahmedabad, India.

• Session co-chair, Session 2: Chemoprevention at the International Conference on Frontiers in Carcinogenesis and Cancer Prevention: Scientific Advances and Public Health Initiatives, February 16-18, 2011, Bangalore, India.

• Invited Speaker talk entitled “Tumor microenvironment: promise and potential in chemoprevention research” at the International Conference on Frontiers in Carcinogenesis and Cancer Prevention: Scientific Advances and Public Health Initiatives, February 16-18, 2011, Bangalore, India.

• Invited Speaker talk entitled “Silibinin efficacy in prostate cancer” at the International Cancer Research Symposium, December 17-22, 2010, Trivandrum, India.

• Organizing committee member for International Cancer Research Symposium, December 17-22, 2010, Trivandrum, India.

• Session co-Chair entitled “Preclinical and clinical investigations of dietary chemopreventive agents” at International Cancer Research Symposium, December 17-22, 2010, Trivandrum, India.

• Invited talk entitled “Develop CEES-induced skin toxicity models, and evaluate silibinin efficacy” at 4th Annual NIH CounterACT Network Research Symposium, June 2010, San Francisco, CA.

• Invited Speaker talk entitled “chemoprevention of prostate cancer by silibinin: bench to bedside” at the Department of Experimental Therapeutics, MD Anderson Cancer Center, October 6th, 2010, Houston, TX.

• Invited Speaker talk entitled “chemoprevention of prostate cancer by silibinin: bench to bedside” at the Department of Molecular Biology and Immunology, UNTHSC, April 12th, 2010, Fort Worth, TX.

• Invited Speaker talk entitled “silibinin and colon cancer” at the Colorado State University Animal Cancer Center, April 5th, 2010, Fort Collins, CO.

• Elected Fellow of AAAS in Pharmaceutical Sciences, December 2009. • Invited Speaker talk entitled “Molecular mechanism of colon cancer

chemoprevention by silibinin” at the International Symposium on Cancer Chemoprevention and Translational Research, December 21st, 2009, JNU, New Delhi, India.

• Invited Speaker talk entitled “Inflammation, Colon Cancer and Silibinin” at the 3rd International Symposium on Translational Cancer Research, December 18th-21st, 2009, Bhubaneswar, India.

• Invited Speaker talk entitled “Efficacy and mechanism of colon cancer chemoprevention by silibinin” at The 2009 China-US Forum on Frontiers of Cancer Research: Focus on Prevention, Changsha, China, October 2009.

• Invited Speaker talk entitled “Skin Cancer Chemoprevention by Silibinin” at the 7th COSTAM/SFRR (ASIA/MALAYSIA) International Worshop – Chemoprevention and Translational Research, July 9-12, 2009, Langkawi, Malaysia.

• Invited Speaker talk entitled “Molecular Mechanism of Cell Death by Silibinin in colon cancer: Apoptosis versus Autophagy” at the Symposium Apoptosis: Mechanisms of


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cell death and therapeutic implications. Faculty of Allied Health Sciences and UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia, July 8th, 2009.

• Outstanding Achievement Award, Society of American Asian Scientists in Cancer Research, April 2009.

• Keynote address entitled “Antiangiogenic efficacy of silibinin in various epithelial tumor models - a major step forward in Cancer Angioprevention Research” at Inhibitors of angiogenesis: design, synthesis and biological exploitation (ANGIOKEM). Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, April 2-4, 2009.

• Organizing Chair of the International Symposium on “Novel Strategies for Targeted Prevention and Treatment of Cancer” at the School of Life Sciences, JNU, New Delhi, India, December 19-20, 2008.

• Invited Speaker talk entitled “Recent advances in cancer prevention by grape seed extract” at NGWI Grape Health Workshop, San Francisco, CA. December 2-3, 2008.

• Invited Speaker talk entitled “Lung cancer chemoprevention by silibinin” at L.S. Skaggs Biomedical Research Symposium, University of Utah, Salt Lake City, UT. November 10-11, 2008.

• Invited Speaker talk entitled “Skin injury models with CEES” at SM Symposium, Albuquerque, NM. November 5-7, 2008.

• Invited talk entitled “Silibinin efficacy in prostate cancer: bench to bedside” at Saint Louis University Cancer Center, November 3rd, 2008.

• Visiting Professor to teach the topic “Ethics in Research with focus on Collaboration, Authorship, Resource Sharing and Mentoring” in a group discussion format to post-graduate students at the School of Life Sciences, JNU, New Delhi, India, October 2008.

• Invited Speaker talk entitled “Molecular Mechanism of Skin Cancer Chemoprevention by Silibinin” at 3rd Hormel Institute Symposium Frontiers in Cancer Research and The 8th International Skin Carcinogenesis Conference, The Hormel Institute, Austin, MN. October 4-7, 2008.

• Invited talk entitled “Prostate cancer chemoprevention by silibinin: bench to bedside” at Department of Surgery and The Tang Center for Herbal Medicine Research, University of Chicago Medical Center, Chicago, IL, September 9, 2008.

• Dean’s Distinguished Lecture entitled “Chemoprevention of Prostate Cancer by Silibinin: Bench to Bedside” at Office of Life Sciences, National University of Singapore, Singapore, January 14th, 2008.

• Invited talk entitled “Silibinin and Angioprevention – an upcoming strategy” at the 2nd International Symposium on Translational Research on Natural Products and Cancer. Lonavala, Mumbai, India, December 9-12, 2007.

• Key Note Address entitled “Chemoprevention of Prostate Cancer by Silibinin: Bench to Bedside” at 18th All India Congress of Zoology and SCIAZE, University of Lucknow, Lucknow, India, December 7-9, 2007.

• Invited talk entitled “Lung cancer chemoprevention by silibinin” at the 9th International Conference on Mechanisms of Antimutagenesis and Anticarcinogenesis. Jeju Island, S. Korea, December 1-5, 2007.


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• Invited talk entitled “Prostate Cancer chemoprevention by silibinin: bench to bedside” at Department of Pathology, UCDHSC, Aurora, CO, October 26th, 2007.

• Co-chaired session entitled “Alternative Medicine and Cancer Chemoprevention” at 12th World Congress on Advances in Oncology and 10th International Symposium on Molecular Medicine: Bioactive Food Components, Alternative Medicine and Cancer Chemoprevention: Recent Advances. Crete, Greece, October, 2007.

• Invited talk entitled “Recent advances in mechanism of cancer chemoprevention by grape seed extract” at 12th World Congress on Advances in Oncology and 10th International Symposium on Molecular Medicine: Bioactive Food Components, Alternative Medicine and Cancer Chemoprevention: Recent Advances. Crete, Greece, October, 2007.

• Invited talk entitled “Dietary Supplement Milk Thistle Extract and Prostate Cancer: Mechanisms and Efficacy” at the Monthly Lecture Series of the Office of Cancer Complementary and Alternative Medicine, NCI, NIH, Bethesda, MD, May 9th, 2007.

• Shell Award Lecture entitled “Silibinin Efficacy in Cancer Models – An Update”, at Shell Prize Symposium on Cancer Chemo-Prevention, School of Pharmacy, UCDHSC, Denver, CO, March 30th, 2007.

• Organizer of the Shell Prize Symposium on Cancer Chemo-Prevention, School of Pharmacy, UCDHSC, Denver, CO, March 30th, 2007.

• Invited talk entitled “Molecular mechanism of prostate cancer prevention by a dietary nutrient inositol hexaphosphate” at Natural Products, Diets and Cancer Prevention Session of the American Chemical Society National Meeting, Chicago, IL. March 25th, 2007.

• Invited talk entitled “Prostate cancer prevention by flavonoid silibinin” at 4th Bio/Molecular Informatics Center International Symposium entitled “Flavonoids: old subjects but new challenges” held at Konkuk University, Seoul, Korea; February 7, 2007.

• Invited talk entitled “Prostate cancer prevention by silibinin: mechanisms and efficacy” at University of Connecticut Health Sciences Center, Center for Molecular Medicine, January 24th, 2007.

• Invited talk entitled “Chemoprevention of prostate cancer by silibinin” at UC Davis, December 7th, 2006.

• Recipient of 2006 Shell Award for outstanding achievements in research and graduate education, School of Pharmacy, University of Colorado Denver.

• Invited talk entitled “Prostate cancer prevention by silibinin” at The International Radiation Oncology Conference Special Session on Cancer Chemoprevention, Varanasi, India, November 20-22, 2006.

• Invited talk entitled “Molecular mechanism of prostate cancer prevention by a dietary nutrient inositol hexaphosphate” at The 3rd APOCP Conference “Empowering Cancer Prevention in the Asian Pacific”, Bangkok, Thailand, November 3-5, 2006.

• Invited talk entitled “Molecular Pathways of Silibinin Efficacy against Skin Cancer” at University of Colorado Cancer Center Seminar Series, Aurora, CO, September 26th, 2006.

• Invited talk entitled “Molecular Pathways of Silibinin Efficacy against Skin Cancer” at Nelson Institute of Environmental Medicine, NYU, Tuxedo, NY, September 22nd, 2006.


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• Invited talk entitled “Skin Cancer Prevention by Silibinin” at 2006 International Conference Frontiers of Pharmacology and Toxicology, Chicago, IL, August 29th, 2006.

• Invited talk entitled “Molecular Mechanism of Skin Cancer Chemoprevention by Silibinin” at Division of Molecular Biology and Molecular Oncology, Evanston Northwestern Research Institute, Evanston, IL, May 9th, 2006.

• Invited talk entitled “Silibinin Efficacy against Prostate Cancer: Bench to Bedside” at Karmanos Cancer Institute Grand Round Seminar Series, Detroit, MI, April 27th, 2006.

• Invited talk entitled “Cell cycle regulators are potential targets for IP6 efficacy in prostate cancer” at 2nd Developmental Therapeutics Program Retreat, UCCC, April 21st, 2006.

• Invited talk entitled “Silibinin Efficacy against Prostate Cancer: Bench to Bedside” at Penn State Cancer Institute, Hershey, PA, March 16th, 2006.

• Invited talk entitled “Molecular Mechanism of Skin Cancer Chemoprevention by Silibinin” at Molecular Toxicology Seminar Series, Penn State University, University Park, PA, March 15th, 2006.

• Invited talk entitled “Molecular Mechanism of Skin Cancer Prevention by an Antioxidant Flavonoid Silibinin” at Animal Cancer Center, Colorado State University, Fort Collins, January 24th, 2006.

• Invited talk entitled “Molecular Mechanisms of Skin Cancer Prevention by Silibinin” at Department of Pharmacology and Toxicology, University of Alabama at Birmingham, January 17th, 2006.

• Invited talk entitled “Modulation of cell cycle regulators in prostate cancer prevention by silibinin”. 3rd Joint Meeting of the Society for Free Radical Research Australia and Japan, Gold Coast, December 2-5, 2005.

• Visiting Scientist, Institute for Nutritional Sciences, Chinese Academy of Sciences, Shanghai, China. October 22nd-28th, 2005.

• Invited talk entitled “Prostate cancer prevention by silibinin”, Institute for Nutritional Sciences, Chinese Academy of Sciences, Shanghai, China. October 2005.

• Invited talk entitled “Prostate cancer prevention by silibinin – bench to bedside” at Targeting Carcinogenesis, Rochester, MN, October 6th to 7th, 2005.

• Invited talk entitled “IP6 prevents prostate cancer by modulating cell cycle regulators”. 24th Annual Convention of IACR, New Delhi, India, February 9-12, 2005.

• Co-chair, Nutraceuticals and Cancer II Session, at the 3rd Int. Conf. on Mechanisms of Action of Nutraceuticals, Asheville, NC, November 12-14, 2004.

• Invited talk entitled “Molecular Mechanism of Silibinin Efficacy in Prostate Cancer” at the 3rd Int. Conf. on Mechanisms of Action of Nutraceuticals, Asheville, NC, November 12-14, 2004.

• Co-chair, Session III at IP6 and Cell Signaling in Fighting Cancer: From Laboratory to Clinic Symposium held at the 7th International Conference of Anticancer Research, Corfu, Greece, October 25-30, 2004.

• Invited talk entitled ”Prostate Cancer Prevention by IP6: Targeting Cell Cycle Regulation” at IP6 and Cell Signaling in Fighting Cancer: From Laboratory to Clinic


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Symposium held at the 7th International Conference of Anticancer Research, Corfu, Greece, October 25-30, 2004.

• Invited talk entitled “Prostate Cancer Chemoprevention by Silibinin” at Dietary Factors and Cancer Prevention: Current Premises and Future Promises, Rochester, MN, September 23-25, 2004.

• Keynote talk entitled “Dietary Agents and Cancer Prevention: How Important Are Pre-clinical Studies” at Pharmacy Student Research Conference, Western Region, Denver, CO, June, 2004.

• Invited talk entitled “Targeting cell signaling and cell cycle regulators: implications in prostate cancer prevention by silibinin” at Basic Pharmaceutical Sciences Faculty Seminar, School of Pharmacy, West Virginia University, Morgantown, WV, April, 2004.

• Invited talk entitled “Molecular mechanism of skin cancer prevention by an antioxidant flavonoid silibinin” at NIOSH, Morgantown, WV, April, 2004.

• Co-chair, Session entitled “Prostate Cancer/Apoptosis” at 8th World Congress on Advances in Oncology, Crete, Greece, October 2003.

• Invited talk entitled “Molecular Mechanism of Silibinin Efficacy in Prostate Cancer” at 8th World Congress on Advances in Oncology, Crete, Greece, October 2003.

• Invited talk entitled “Prostate Cancer Prevention by Silibinin”. Hormel Institute, University of Minnesota, September 25, 2003.

• Invited talk entitled “Silibinin and Prostate Cancer: Targeting EGFR”. 21st Annual Meeting of the Moutain West Society of Toxicology, Breckenridge, CO, September 18-19, 2003.

• Invited talk entitled “Modulation of cell cycle regulators by silibinin in prostate cancer” at Basic Science Seminar Series, UC Cancer Center, UCHSC, Denver, CO, June 2003.

• Invited talk entitled “EGFR is necessary and sufficient for silibinin efficacy: possible role in prostate cancer” at Cell Biology Program Minisymposium – Receptor Dynamics and Cancer, University of Colorado Cancer Center, UCHSC, Denver, CO, April 2003.

• Invited talk on Silibinin and Prostate Cancer at Integrative Medicine Program, University of Colorado Hospital, Aurora, CO, November 2002.

• Invited Speaker and Participant at 1st International Symposium on Cancer Prevention, Montreal, Canada, November 2002.

• Invited talk entitled Modulation of Cell Cycle Regulators in Prostate Cancer Prevention by Silibinin at The Cell Cycle as a Target in Chemoprevention and Cancer Therapy Conference, 3rd International Conference, Austin, TX, October 2002.

• Invited talk entitled Silibinin: preclinical antitumor activity of a natural flavanolignan at Catholic University of the Sacred Heart, sponsored by Prof. G. Scambia, Rome, Italy, July 2002.

• Invited talk entitle Silibinin and Prostate Cancer, and program planning and development at Research Triangle Institute, North Carolina, April, 2002

• Invited talk entitle Skin Cancer Chemoprevention by Silymarin at Basic Science Seminars, University of Colorado Cancer Center, Denver, CO, April, 2002


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• Invited talk entitled Silymarin and Prostate Cancer: Epigenetic Events as Molecular Targets at 1st International Conference on Mechanism of Action of Nutraceuticals, Cavtat-Dubrovnik, Croatia, October 2001.

• Invited talk entitled Silymarin and Skin Cancer Prevention at College of Pharmacy, South Dakota State University, Brookings, SD, September 2001.

• Talk entitled Upcoming Trial on Milk Thistle (Silymarin) at UCHSC Prostate Cancer Support Group Meeting, Denver, CO, September 2001.

• Invited talk entitled Skin Cancer Chemoprevention by Silymarin at Department of Dermatology, Columbia University, New York, NY, August 2001.

• Talk entitled Phytochemicals and Cancer Prevention – An Overview at DOPS, UCHSC Annual Retreat, Winter Park, CO, June 2001.

• Invited Speaker at University of Illinois at Chicago, Department of Pharmaceutics and Pharmacodynamics, Chicago, IL, November 2000.

• Invited Speaker at Exp. Skn Carcinogenesis: 4th International Meeting, Tucson, AZ, 2000.

• Invited Speaker at University of Pittsburgh. Department of Cell Biology & Physiology, Pittsburgh, PA, October 2000.

• Invited Speaker at McGill University, Montreal, Canada, October 2000. • Invited Speaker at Mercy Hospital Cancer Research Institute, Pittsburgh, PA, June

2000. • Inaugoral Talk at AMC Cancer Research Center 2000 – Seminar Series, January

2000. • Invited Speaker at International Conference on Signal Transduction as Molecular

Targets for Therapy, Luxembourg, Luxembourg, January 2000. • Invited Speaker at Univ. of Colorado Cancer Center, Denver, CO, December 1999. • Invited Speaker at Department of Endocrinology, University of Colorado Health

Sciences Center, Denver, CO, December 1999. • Invited Speaker at International Conference on Diet and Prevention of Cancer,

Tampere, Finland, 1999. • Invited speaker at Comprehensive Cancer Center, Ohio State University, OH, 1998. • Invited speaker at Exp. Skin Carcinogenesis: 3rd International Meeting, TX, 1998. • My work showing exceptionally high protective effect of silymarin against

photocarcinogenesis, was covered nationally on TV, radio as well as in several magazines including CWRU Medical School’s MedLines, 1997.

• Work “Anti-carcinogenic effect of a polyphenolic antioxidant silymarin in breast cancer cells MDA-MB468: a p53-independent induction of WAF1/Cip1/p21 and G1 arrest” received an AACR-AFLAC Young Investigator Award for the 88th Annual Meeting of AACR, 1997.

• Invited speaker at MD Anderson Cancer Center, Science Park, Smithville, TX, 1996. • Recipient of Upjohn Company Foundation Career Development Award through

Dermatology Foundation, 1995. • Chaired an Oral Session entitled ‘Mechanism of Carcinogenesis’ at 56th Annual

Meeting of The Society for Investigative Dermatology, 1995. • Chaired an Oral Session entitled ‘UV Photobiology’ at 23rd Annual Meeting of

American Society for Photobiology, 1995.


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• Invited speaker at Department of Dermatology, Roswell Park Cancer Center, Buffalo, 1994.

• Recipient of Upjohn Company Foundation Career Development Award through Dermatology Foundation, 1994.

• Recipient of Upjohn Company Foundation Career Development Award through Dermatology Foundation, 1993.

• Recipient of Young Investigator Travel Award through Organizing Committee to Attend Second Tricontinental Meeting of the JSID, SID and ESDR held at Kyoto, Japan, October 28-31, 1993.

• Recipient of Lila Gruber Cancer Research Award of the American Academy of Dermatology through Dermatology Foundation, 1992.

• Recipient of Robert A. Chesebrough Silver Medal from Chesebrough-Pond’s Inc. for original research work entitled “Effect of VaselineR Petroleum Jelly on absorption, tissue distribution, metabolism and DNA binding of skin carcinogen benzo(a)pyrene, 1990.

• Recipient of Robert A. Chesebrough Bronze Medal from Chesebrough-Pond’s Inc. for original research paper entitled “Effect of VaselineR Petroleum Jelly on benzoyl peroxide-induced ornithine decarboxylase activity in mouse skin, 1990.


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Publications

JOURNAL PUBLICATIONS In the Area of Bio-Organic Chemistry (1979-1989) 1. Tiwari, S.S., Satsangi, R.K., and Agarwal, R.: Synthesis and CNS activity of some

2-aryl/alkyl-3-[N-phenyl, N-(dihydroxy phenylmethyl)-amino]-6, 8-disubstituted-quinazolin-4 (3H)-ones. Curr. Sci., 48:568-571, 1979.

2. Tiwari, S.S., Zaidi, S.M.M., Agarwal, R., and Satsangi, R.K.: 5-Nitro-4(2)-[4-oxo-3H-

quinazolin-3yl]-benzylidene malonylureas as antibacterial agents. J. Ind. Chem. Soc., 57:1039-1040, 1980.

3. Tiwari, S.S., Agarwal, R., and Satsangi, R.K.: Synthesis and CNS activity of 1-

(5’alkyl-1’,3’,4’-thiadiazol-2’-yl)-2-methyl-4-arylidene-imidazol-5 ones. J. Ind. Chem. Soc., 57:1040-1042, 1980.

4. Zaidi, S.M.M., Satsangi, R.K., Kumar, P., Nasir, M., Agarwal, R., and Tiwari, S.S.:

New anti-mycobacterial hydantoins. Die Pharmazie, 35:740-741, 1980. 5. Agarwal, R., Shukla, M.K., and Satsangi, R.K.: Synthesis and CNS activity of 5-

arylidene-3-arylaminomethyl-4-thiazolidinon-2-thiones. Curr. Sci., 49:455-456, 1980. 6. Agarwal, R., Satsangi, R.K., Misra, S., and Tiwari, S.S.: Synthesis and CNS activity

of 2-aryl-3-(substituted-phenoxy-acetyl hydrazono)-methylenyl-indoles. Curr. Sci., 50:66-68, 1981.

7. Tiwari, S.S., Agarwal, R., and Satsangi, R.K.: Search for CNS active agents:

Synthesis of N,N’-bis-[potassium-alkly/aryl-carboxylate]-5-arylidene barbituric acids. Pol. J. Pharmacol. Pharm., 33:115-120, 1981.

8. Agarwal, R., Shukla, M.K., Satsangi, R.K., and Chaudhary, C.: Synthesis of 1-{p-[3-

(2’oxo/thiobenzoxazolinyl methyl)-amino] benzoyl}-4-aryl/methyl-piperazines as CNS active agents. Ind. J. Chem., 20B:680-682, 1981.

9. Agarwal, R., Satsangi, R.K., and Tiwari, S.S.: Synthesis and CNS activity of 1,5-

disubstituted-3-(4’-acetamidophenoxyacetyl hydrazono) indolin-2-ones. Ind. J. Chem., 20B:1099-1100, 1981.

10. Misra, S., Satsangi, R.K., Agarwal, R., and Tiwari, S.S.: Synthesis of 2-substituted

phenyl-3-aryloxyacetyl hydrazono methylenyl-indoles as central nervous system active agents. J. Chem. Soc. Pak., 3:199-202, 1981.

11. Agarwal, R., Satsangi, R.K., and Tiwari, S.S.: Chemistry and CNS activity of 1-(4-

methyl-coumarin-7yl)-oxyacetyl-3-methyl-4-(substituted-phenylhydrazono/azo) pyrazolin-5-ones. J. Chem. Soc. Pak., 3:203-208, 1981.


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12. Misra, V.S., Singh, C., Agarwal, R., and Chaudhary, C.: Synthesis of 2-styryl-3,6,8-trisubstituted quinazolin-4(3H) ones as anti-inflammatory agents. J. Chem. Soc. Pak., 3:209-213, 1981.

13. Agarwal, R., Satsangi, R.K., and Tiwari, S.S.: Synthesis and CNS activities of some

newer indole derivatives. J. Chem. Soc. Pak., 4:43-47, 1982. 14. Agarwal, R., Chaudhary, C., Srivastava, V.K., and Misra, V.S.: Synthesis of 1-(2-

arylindol-3yl)-2-[3-(p-substituted phenyl)-6-substituted-quinazolin-4-one-2yl]-ethenes as CNS active agent. Acta Pharm. Jugosl., 32:37-44, 1982.

15. Agarwal, R., Chaudhary, C., and Misra, V.S.: Effect of mild bases on the yield of

Knoevenagel products: Synthesis of some N1-substituted 4-arylidene-3-methyl-_2-pyrazolin-5-ones under different basic conditions. Ind. J. Chem., 21B:109-111, 1982.

16. Agarwal, R., Chaudhary, C., Singh, C., and Misra, V.S.: Synthesis of 2-methoxy-

4(3-methyl-5-oxo 1-phenyl-4-pyrazolylidenemethyl)-phenoxyacetic acid and its ethyl ester. Ind. J. Chem., 21B:152-153, 1982.

17. Agarwal, R., Misra, S., Satsangi, R.K., and Tiwari, S.S.: Synthesis and CNS activity

of N,N-disubstituted-1-(aminomethyl)-5-alkyl-3-(aryloxyacetyl hydrazono) indolin-2-ones. Arch. Pharm., 315:142-146, 1982.

18. Agarwal, R., Shukla, M.K., and Satsangi, R.K.: Synthesis and CNS activity of 4-aryl-

1-p-(substituted benzamido)-piperazines. Ind. J. Pharm., 14:177-182, 1982. 19. Misra, V.S., Chaudhary, C., and Agarwal, R.: Synthesis of N1-(2,4-dinitrophenyl

acetyl)-3-methyl-4-(substituted phenyl-hydrazono/azo)-pyrazolin-5-ones. Ind. J. Chem., 21B:466-467, 1982.

20. Singh, C., Agarwal, R., Chaudhary, C., and Misra, V.S.: Synthesis of 1-(N,N-

disubstituted-aminomethyl)-2-oxo-3-(2,4-dinitrophenylacetyl hydrazono)-5-substituted-indoles as anti-inflammatory agents. J. Chem. Soc. Pak., 4:215-219, 1982

21. Agarwal, R., Chaudhary, C., and Misra, V.S.: Synthesis and CNS activity of 4-

arylideneamino-N,N-diphenylbenzamides, 1-[p-(N,N diphenylcarbamoyl) phenyl]-3-(p-substituted phenyl) thioureas and 6-substituted 3-[N-(3H-2-methyl-4-oxo-3-quinazolylamino)methyl] 2-oxo/thio-benzoxazoles. Ind. J. Chem., 21B:1110-1113, 1982.

22. Chaudhary, C., Agarwal, R., and Misra, V.S.: Synthesis of 2-aryl-3-(3-disubstituted

aminomethyl-2-thio-4-oxo-thiazolidin-5yl)-methylenyl-indoles as CNS active agents. Proc. Ind. Acad. Sci., 91:483-489, 1982.


32

23. Agarwal, R., Chaudhary, C., and Misra, V.S.: Synthesis of 2-aryl-1-(4-morpholinophenyl)-4-(3,4-disubstituted-benzylidene) imidazolin-5-ones as CNS active agents. Ind. J. Chem., 22B:308-310, 1983.

24. Singh, C., Agarwal, R., and Misra, V.S.: Synthesis of 2-thio 3-arylamino/

disubstituted amino-methyl-4-oxo-5-cinnamylidene-thiazolidines as CNS and anti-inflammatory agents. Curr. Sci., 52:305-308, 1983.

25. Mohan, R.R., Agarwal, R., and Misra, V.S.: Synthesis and pharmacological

screening of 2-thio-3-arylaminomethyl-4-oxo-5-(3,4-disubstituted benzylidene) thiazolidines. Indian Drugs, 21:90-95, 1983.

26. Agarwal, C., Agarwal, R., Gupta, P.N., Srivastava, V.K., and Misra, V.S.: Synthesis

of 1-dialkylaminomethyl-2-oxo-3-(3’-cyclohexylpropanonyl) hydrazono-5-substituted indoles as possible psychotropic agents. Acta Pharm. Jugosl., 33:183-192, 1983.

27. Mohan, R.R., Agarwal, C., Agarwal, R., and Misra, V.S.: CNS, anthelmintic and anti-

inflammatory activities of some 1-[2/3-(2-phenyl benzimidazole] 2-methyl/phenyl-4 (3,4-disubstituted benzylidene) 5-oxo-imidazoles. Pharm. Res. Comm., 16:321-338, 1984.

28. Agarwal, R., Agarwal, C., Singh, C., and Misra, V.S.: Synthesis of 1-(2-arylindol-

3yl)- 2[3-(p-morpholinophenyl)- 6,8-disubstituted-quinazolin- 4(3H)- one-2yl] ethenes as CNS active and anti-inflammatory agents. J. Chem. Soc. Pak., 6:89-94, 1984.

29. Agarwal, R., Agarwal, C., and Kumar, P.: Antitubercular and CNS activities of some

2-aryl-3- [N-(2/3/4-benzimidazol-2yl)phenyl]- iminomethylenyl-indoles. Pharm. Res. Comm., 16:831-844, 1984.

30. Mohan, R.R., Agarwal, R., and Misra, V.S.: Synthesis of some newer quinazolinyl-

oxadiazoles, thiosemicarbazides and thiadiazoles as pharmacologically active agents. Ind. J. Chem., 24B:78-82, 1985.

31. Mohan, R.R., Agarwal, R., and Misra, V.S.: Synthesis of 2/9-substituted

indophenazin-6-acetic acid a-aryl/methyl benzylidene hydrazides, 4-aryl-1-(indophenazin-6-methylcarbonyl)-3-thiosemicarbazides and 6-(4-aryl-5-mercapto-4H-1,2,4-triazol-3yl methyl) indophenazines as CNS active and anti-inflammatory agents. Ind. J. Chem., 25B:1234-1237, 1986.

32. Agarwal, R., Bhargava, S.K., Kidwai, M.M., Mehrotra, N.K., and Lal, M.M.:

Estimation of benzo(a)pyrene in ambient air of different areas of Lucknow city. Proceedings of National Symposium on chemical carcinogenesis and carcinogens in the environment. 136-138, 1988.


33

33. Agarwal, R., Agarwal, C., Singh, C., Mohan, R.R., and Misra, V.S.: Synthesis of 6-substituted indophenazines as possible psychotropic and anti-inflammatory agents. Acta Pharm. Jugosl., 38:11-21, 1988.

34. Agarwal, R., Singh, C., and Misra, V.S.: CNS and anti-inflammatory activities of

some newer oxo-imidazolidenes. Indian Drugs, 25:185-190, 1988. 35. Agarwal, R., Agarwal, C., Singh, C., and Misra, V.S.: Synthesis of 1-substituted-2-

oxo-3-chloro/(2-chlorophenoxy)-4-(2 arylindol-3yl) azetidines as CNS active and antiinflammatory agents. Ind. J. Chem., 28B:893-896, 1989.

In the Areas of Biological Sciences and Cancer Biology/Pharmacology (1985 to date) 36. Agarwal, R., Kumar, S., Shukla, Y., Antony, M., and Mehrotra, N.K.: Quantification

of tumour initiating effect of Jute Batching Oil and its distillates over mouse skin. Cancer Lett., 28:281-290, 1985.

37. Agarwal, R., Kumar, S., and Mehrotra, N.K.: Polyaromatic hydrocarbon profile of a

mineral oil (JBO-P) by gas chromatography. J. Chrom. Sci., 24:289-292, 1986. 38. Agarwal, R., Gupta, K.P., Kumar, S., and Mehrotra, N.K.: Assessment of some

tumourigenic risks associated with fresh and used cutting oil. Ind. J. Exptl. Biol., 24:508-510, 1986.

39. Mehrotra, N.K., Kumar, S., Agarwal, R., and Antony, M.: Jute Batching oil: a tumor

promoter on mouse skin. Environ. Res., 42:12-23, 1987. 40. Agarwal, R., Shukla, Y., Kumar, S., and Mehrotra, N.K.: Evaluation of carcinogenic

effect of jute batching oil (JBO-P) fractions following topical application to mouse skin. Arch. Toxicol., 62:406-410, 1988.

41. Rajasekharan, K.N., Mayadevi, M., Agarwal, R., and Burke, M.: MgADP-induced

changes in the structure of myosin S1 near the ATPase-related thiol SH1 probed by cross-linking. Biochemistry, 29:3006-3013, 1990.

42. Agarwal, R., Athar, M., Bickers, D.R., and Mukhtar, H.: Evidence for the

involvement of singlet oxygen in the photodestruction by chloroaluminum phthalocyanine tetrasulfonate. Biochem. Biophys. Res. Commun., 173:34-41, 1990.

43. Agarwal, R., Rajasekharan, K.N. and Burke, M.: Identification of the site of

photocross-linking formed in the absence of magnesium nucleotide from SH2 (cys-697) in myosin subfragment 1 labeled with 4’-maleimidylbenzophenone. J. Biol. Chem., 266:2272-2275, 1991.

44. Wang, Z.Y., Agarwal, R., Zhou, Z.C., Bickers, D.R. and Mukhtar, H.: Inhibition of

mutagenicity in Salmonella typhimurium and skin tumor initiating and tumor


34

promoting activities in Sencar mice by glycyrrhetinic acid: Comparison of 18α- and 18β-stereoisomers. Carcinogenesis, 12:187-192, 1991.

45. Agarwal, R., Athar, M., Urban, S.A., Bickers, D.R., and Mukhtar, H.: Involvement of

singlet oxygen in chloroaluminum phthalocyanine tetrasulfonate-mediated photoenhancement of lipid peroxidation in rat epidermal microsomes. Cancer Lett., 56:125-129, 1991.

46. Agarwal, R., Wang, Z.Y., and Mukhtar, H.: Inhibition of skin tumor initiating activity

of DMBA by chronic oral feeding of glycyrrhizin in drinking water. Nutrition and Cancer, 15:187-193, 1991.

47. Agarwal, R., Wang, Z.Y., Bik, D.P., and Mukhtar, H.: Nordihydroguaiaretic acid, an

inhibitor of lipoxygenase, also inhibits cytochrome P 450-mediated monooxygenase activity in rat epidermal and hepatic microsomes. Drug Metab. Dispos., 19:620-624, 1991.

48. Wang, Z.Y., Agarwal, R., Bickers, D.R., and Mukhtar, H.: Protection against

ultraviolet B radiation-induced photocarcinogenesis in hairless mice by green tea polyphenols. Carcinogenesis, 12:1527-1530, 1991.

49. Agarwal, R. and Burke, M.: Temperature induced changes in the flexibility of the

loop between SH1 (cys-707) and SH3 (cys-522) in myosin subfragment 1 detected by cross-linking. Arch. Biochem. Biophys., 290:1-6, 1991.

50. Agarwal, R., Medrano, E.E., Khan, I.U., Nordlund, J.J. and Mukhtar, H.: Metabolism

of benzo(a)pyrene by human melanocytes in culture. Carcinogenesis, 12:1963-1966, 1991.

51. Wang, Z.Y., Agarwal, R., Zhou, Z.C., Bickers, D.R. and Mukhtar, H.: Antimutagenic

and antitumorigenic activities of nordihydroguaiaretic acid. Mutation Res., 261:153-162, 1991.

52. Athar, M., Agarwal, R., Wang, Z.Y., Lloyd, J.R., Bickers, D.R. and Mukhtar, H.: All

trans retinoic acid protects against conversion of chemically induced- and ultraviolet B radiation-induced skin papillomas to carcinomas. Carcinogenesis, 12:2325-2329, 1991.

53. Mukhtar, H., Agarwal, R., Athar, M., Lewen, R.L., Elmets, C.A., and Bickers, D.R.:

Photodynamic therapy of murine skin tumors by Photofrin II. Photodermatol. Photoimmunol. Photomed., 8:169-175, 1991.

54. Raza, H., Agarwal, R., Bickers, D.R., and Mukhtar, H.: Purification and molecular

characterization of b-naphthoflavone- inducible cytochrome P-450 from rat epidermis. J. Invest. Dermatol., 98:233-240, 1992.


35

55. Agarwal, R., Zaidi, S.I.A., Athar, M., Bickers, D.R. and Mukhtar, H.: Photodynamic effects of chloroaluminum phthalocyanine tetrasulfonate are mediated by singlet oxygen: in vivo and in vitro studies utilizing hepatic microsomes as model membrane source. Arch. Biochem. Biophys., 294:30-37, 1992.

56. Mukhtar, H., Wang, Z.Y., Katiyar, S.K. and Agarwal, R.: Tea components:

Antimutagenic and anticarcinogenic effects. Preventive Medicine, 21:351-360, 1992. 57. Agarwal, R., Katiyar, S.K., Zaidi, S.I.A. and Mukhtar, H.: Inhibition of skin tumor

promoter-caused induction of epidermal ornithine decarboxylase in SENCAR mice by polyphenolic fraction isolated from green tea and its individual epicatechin derivatives. Cancer Res., 52:3582-3588, 1992.

58. Agarwal, R., Athar, M., Elmets, C.A., Bickers, D.R. and Mukhtar, H.: Photodynamic

therapy of chemically- and ultraviolet B radiation-induced murine skin papillomas by chloroaluminum phthalocyanine tetrasulfonate. Photochem. Photobiol., 56:43-50, 1992.

59. Khan, S.G., Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Enhancement of antioxidant

and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: possible role in cancer chemoprevention. Cancer Res., 52:4050-4052, 1992.

60. Wang, Z.Y., Agarwal, R., Khan, W.A. and Mukhtar, H.: Protection against

benzo(a)pyrene and N-nitrosodiethylamine-induced lung and forestomach tumorigenesis in A/J mice by water extracts of green tea and licorice. Carcinogenesis, 13:1491-1494, 1992.

61. Katiyar, S.K., Agarwal, R., Wang, Z.Y., Bhatia, A.K. and Mukhtar, H.: (-)-

Epigallocatechin-3-gallate in Camellia sinensis leaves from Himalayan region of Sikkim: Inhibitory effects against biochemical events and tumor initiation in SENCAR mouse skin. Nutrition and Cancer, 18:73-83, 1992.

62. Agarwal, R., Raza, H., Allyn, D.L., Bickers, D.R. and Mukhtar, H.: Glutathione S-

transferase dependent conjugation of leukotriene A4 methyl ester to leukotriene C4 methyl ester in mammalian skin. Biochem. Pharmacol., 44:2047-2053, 1992.

63. Katiyar, S.K., Agarwal, R., Wood, G.S. and Mukhtar, H.: Inhibition of 12-O-

tetradecanoylphorbol-13-acetate-caused tumor promotion in 7,12-dimethylbenz[a]anthracene-initiated SENCAR mouse skin by a polyphenolic fraction isolated from green tea. Cancer Res., 52:6890-6897, 1992.

64. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Green tea in chemoprevention of

cancer. Comprehensive Therapy, 18:3-8, 1992.


36

65. Katiyar, S.K., Agarwal, R., Ekker, S., Wood, G.S. and Mukhtar, H.: Protection against 12-O-tetradecanoylphorbol-13-acetate-caused inflammation in SENCAR mouse ear skin by polyphenolic fraction isolated from green tea. Carcinogenesis, 14:361-365, 1993.

66. Katiyar, S.K., Agarwal, R., Zaim, M.T. and Mukhtar, H.: Protection against N-

nitrosodiethylamine and benzo(a)pyrene-induced forestomach and lung tumorigenesis in A/J mice by green tea. Carcinogenesis, 14:849-855, 1993.

67. Sutter, C., Strickland, P.T., Mukhtar, H., Agarwal, R., Winter, H. and Schweizer, J.:

Ras gene activation and aberrant expression of keratin K13 in ultraviolet B radiation- induced epidermal neoplasias of mouse skin. Mol. Carcinogenesis, 8:13-19, 1993.

68. Zaidi, S.I.A., Agarwal, R., Eichler, G., Rihter, B.D., Kenney, M.E. and Mukhtar, H.:

Photodynamic effects of new silicon phthalocyanines: in vitro studies utilizing rat hepatic microsomes and human erythrocyte ghosts as model membrane sources. Photochem. Photobiol., 58:204-210, 1993.

69. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Protection against malignant conversion

of chemically-induced benign skin papillomas to squamous cell carcinomas in SENCAR mice by a polyphenolic fraction isolated from green tea. Cancer Res., 53:5409-5412, 1993.

70. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Protective effects of green tea

polyphenols administered by oral intubation against chemical carcinogen-induced forestomach and pulmonary neoplasia in A/J mice. Cancer Letters, 73:167-172, 1993.

71. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Inhibition of both stage I and stage II

skin tumor promotion in SENCAR mice by a polyphenolic fraction isolated from green tea: Inhibition depends on the duration of polyphenol treatment. Carcinogenesis, 14:2641-2643, 1993.

72. Agarwal, R., Katiyar, S.K., Khan, S.G. and Mukhtar, H.: Protection against

ultraviolet B radiation-induced effects in the skin of SKH-1 hairless mice by a polyphenolic fraction isolated from green tea. Photochem. Photobiol., 58: 695-700, 1993.

73. Agarwal, R., Khan, S.G., Athar, M., Zaidi, S.I.A., Bickers, D.R. and Mukhtar, H.: Ras

protein p21 processing enzyme farnesyltransferase in chemical carcinogen-induced murine skin tumors. Mol. Carcinogenesis, 8:290-298, 1993.

74. Mukhtar, H., Katiyar, S.K. and Agarwal, R.: Green tea and skin - anticarcinogenic

effects. J. Invest. Dermatol., 102:3-7, 1994.


37

75. Agarwal, R., Jugert, F.K., Khan, S.G., Bickers, D.R., Merk, H.F. and Mukhtar, H.: Evidence for multiple inducible cytochrome P450 isozymes in SENCAR mouse skin by pyridine. Biochem. Biophys. Res. Commun., 199:1400-1406, 1994.

76. Khan, S.G., Bickers, D.R., Mukhtar, H. and Agarwal, R.: Ras p21 farnesylation in

ultraviolet B radiation-induced tumors in the skin of SKH-1 hairless mice. J. Invest. Dermatol., 102:754-758, 1994.

77. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Inhibition of spontaneous and photo-

enhanced lipid peroxidation in mouse epidermal microsomes by epicatechin derivatives from green tea. Cancer Lett., 79:61-66, 1994.

78. Jugert, F.K., Agarwal, R., Kuhn, A., Bickers, D.R., Merk, H.F. and Mukhtar, H.:

Multiple cytochrome P450 isozymes in murine skin: Induction of P450 1A, 2B, 2E and 3A by dexamethasone. J. Invest. Dermatol., 102:970-975, 1994.

79. Agarwal, R., Katiyar, S.K., Lundgren, D.W. and Mukhtar, H.: Inhibitory effect of

silymarin, an anti-hepatotoxic flavonoid, on 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity and mRNA in SENCAR mice. Carcinogenesis, 15:1099-1103, 1994.

80. Mukhtar, H., Zaidi, S.I.A., Raza, H. and Agarwal, R.: Differential expression of

glutathione S-transferase isozymes in murine and human skin tumors. Int. J. Oncology, 6:37-43, 1995.

81. Khan, S.G., Saxena, R., Bickers, D.R., Mukhtar, H. and Agarwal, R.: Inhibition of

ras p21 membrane localization and modulation of protein kinase C isozyme expression during regression of chemical carcinogen-induced murine skin tumors by lovastatin. Mol. Carcinogenesis, 12:205-212, 1995.

82. Khan, S.G., Mukhtar, H. and Agarwal, R.: A rapid and convenient filter-binding

assay for ras p21 processing enzyme farnesyltransferase. J. Biochem. Biophys. Methods, 30:133-144, 1995.

83. Agarwal, R. and Mukhtar, H.: Cancer chemoprevention by polyphenolic compounds

present in green tea. Drug News & Perspective, 8:216-225, 1995. 84. Katiyar, S.K., Rupp, C.O., Korman, N.J., Agarwal, R. and Mukhtar, H.: Inhibition of

12-O-tetradecanoylphorbol-13-acetate and other skin tumor promoter-caused induction of epidermal interleukin-1a mRNA and protein expression in SENCAR mice by green tea polyphenols. J. Invest. Dermatol., 105:394-398, 1995.

85. Katiyar, S.K., Elmets, C.A., Agarwal, R. and Mukhtar, H.: Protection against

ultraviolet B radiation-induced local and systemic suppression of contact hypersensitivity and edema responses in C3H/HeN mice by green tea polyphenols. Photochem. Photobiol., 62:855-861, 1995.


38

86. Khan, S.G., Mohan, R.R., Katiyar, S.K., Wood, G.S., Bickers, D.R., Mukhtar, H. and

Agarwal, R.: Mutations in ras oncogenes: Rare event in ultraviolet B radiation-induced mouse skin tumorigenesis. Mol. Carcinogenesis, 15:96-103, 1996.

87. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Inhibition of tumor promotion in

SENCAR mouse skin by ethanol extract of Gingiber officinale rhizome. Cancer Res., 56:1023-1030, 1996.

88. Agarwal, R. and Mukhtar, H.: Chemoprevention of photocarcinogenesis.

Photochem. Photobiol., 63:440-444, 1996. 89. Agarwal, R., Korman, N.J., Mohan, R.R., Jawed, S., Zaim, M.T. and Mukhtar, H.:

Apoptosis is an early event during phthalocyanine-photodynamic therapy-induced ablation of murine skin tumors. Photochem. Photobiol., 63:547-552, 1996.

90. Khan, S.G., Dummer, R., Siddiqui, J, Bickers, D.R., Agarwal, R. and Mukhtar, H.:

Farnesyltransferase activity and mRNA expression in human skin basal cell carcinomas. Biochem. Biophys. Res. Commun., 220:795-801, 1996.

91. Mohan, R.R., Katiyar, S.K., Khan, S.G., Zaim, M.T., Mukhtar, H. and Agarwal, R.:

Protective effect of all trans retinoic acid against tumor promotion and progression in low- and high-risk protocols of mouse skin chemical carcinogenesis. Int. J. Oncology, 8:1079-1088, 1996.

92. Mukhtar, H. and Agarwal, R.: Skin cancer chemoprevention. J. Invest. Dermatol.

Symposium Proceedings, 1:209-214, 1996. 93. Agarwal, R., Mohan, R.R., Ahmad, N. and Mukhtar, H.: Protection against malignant

conversion in SENCAR mouse skin by all trans retinoic acid: Inhibition of the ras p21-processing enzyme farnesyltransferase and Ha-ras p21 membrane localization. Mol. Carcinogenesis, 17:13-22, 1996.

94. Ahmad, N., Agarwal, R. and Mukhtar, H.: Cytochrome P450-dependent drug

metabolism in skin. Clinics in Dermatol., 14:407-415, 1996. 95. Singh, S.V., Mohan, R.R., Agarwal, R., Benson, P.J., Hu, X., Rudy, M.A., Xia, H.,

Katoh, A., Srivastava, S.K., Mukhtar, H., Gupta, V. and Zaren, H.A.: A novel anti-carcinogenic activity of an organosulfide from garlic: Inhibition of H-ras oncogene transformed tumor growth in vivo by diallyl disulfide is associated with inhibition of p21H-ras processing. Biochem. Biophys. Res. Commun., 225:660-665, 1996.

96. Chatterjee, M.L., Agarwal, R. and Mukhtar, H.: Ultraviolet B radiation-induced DNA

lesions in mouse epidermis: an assessment using a novel 32P-postlabelling technique. Biochem. Biophys. Res. Commun., 229:590-595, 1996.


39

97. Ahmad, N., Agarwal, R. and Mukhtar, H.: Cytochrome P450 and drug development for skin diseases. Skin Pharmacol., 9:231-241, 1996.

98. Katiyar, S.K., Mohan, R.R., Agarwal, R. and Mukhtar, H.: Protection against

induction of mouse skin papillomas with low- and high-risk for conversion to malignancy by green tea polyphenols. Carcinogenesis, 18:497-502, 1997.

99. Ahmad, N., Srivastava, R.C., Agarwal, R. and Mukhtar, H.: Nitric oxide synthase

and skin tumor promotion. Biochem. Biophys. Res. Commun., 232:328-331, 1997. 100. Katiyar, S.K., Korman, N.J., Mukhtar, H. and Agarwal, R.: Protective effects of

silymarin against photocarcinogenesis in mouse skin model. J. Natl. Cancer Inst., 89: 556-566, 1997.

101. Srivastava, S.K., Hu, X., Xia, H., Zaren, H.A., Chatterjee, M.L., Agarwal, R. and

Singh, S.V.: Mechanism of differential efficacy of organosulfides in preventing benzo(a)pyrene-induced cancer in mice. Cancer Lett., 118: 61-67, 1997.

102. Ahmad, N., Feyes, D.K., Nieminen, A.-L., Agarwal, R. and Mukhtar, H.: Green tea

constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells. J. Natl. Cancer Inst., 89:1881-1886, 1997.

103. Zi, X., Mukhtar, H. and Agarwal, R.: Novel cancer chemopreventive effects of a

flavonoid antioxidant silymarin: Inhibition of mRNA expression of an endogenous tumor promoter TNFa. Biochem. Biophys. Res. Commun., 239: 334-339, 1997.

104. Zi, X., Feyes, D.K. and Agarwal, R.: Anti-carcinogenic effect of a flavonoid

antioxidant silymarin in human breast cancer cells MDA-MB 468: Induction of G1 arrest through an increase in Cip1/p21 concomitant with a decrease in kinase activity of CDKs and associated cyclins. Clin. Cancer Res., 4: 1055-1064, 1998.

105. Zi, X., Grasso, A.W., Kung, H.-J. and Agarwal, R.: A flavonoid antioxidant silymarin

inhibits activation of erbB1 signaling, and induces cyclin-dependent kinase inhibitors, G1 arrest and anti-carcinogenic effects in human prostate carcinoma DU145 cells. Cancer Res., 58: 1920-1929, 1998.

106. Ahmad, N., Gali, H., Javed, S. and Agarwal, R.: Skin cancer chemopreventive

effects of a flavonoid antioxidant silymarin are mediated via impairment of receptor tyrosine kinase signaling and perturbation in cell cycle progression. Biochem. Biophys. Res. Commun., 247: 294-301, 1998.

107. Ahmad, N., Feyes, D.K., Agarwal, R. and Mukhtar, H.: Photodynamic therapy

results in induction of WAF1/CIP1/P21 leading to cell cycle arrest and apoptosis. Proc. Natl. Aca. Sci. USA, 95: 6977-6982, 1998.


40

108. Mohan, R.R., Challa, A., Gupta, S., Bostwick, D.G., Ahmad, N., Agarwal, R., Marengo, S.R., Amini, S.B., MacLennan, G.T., Paras, F., Resnick, M.I. and Mukhtar, H.: Overexpression of ornithine decarboxylase in prostate cancer and prostatic fluid in humans. Clin. Cancer Res., 5:143-147, 1999.

109. Lahiri-Chatterjee, M., Katiyar, S.K., Mohan, R.R. and Agarwal, R.: A flavonoid

antioxidant, silymarin, affords exceptionally high protection against tumor promotion in SENCAR mouse skin tumorigenesis model. Cancer Res., 59:622-632, 1999.

110. Zi, X. and Agarwal, R.: Silibinin decreases prostate-specific antigen with cell growth

inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells: Implications for prostate cancer intervention. Proc. Natl. Acad. Sci. USA, 96:7490-7495, 1999.

111. Zhao, J., Wang, J., Chen, Y. and Agarwal, R.: Anti-tumor promoting activity of a

polyphenolic fraction isolated from grape seeds in mouse skin two-stage initiation-promotion protocol, and identification of procyanidin B5-3’-gallate as the most effective antioxidant constituent. Carcinogenesis, 20:1737-1745, 1999.

112. Zhao, J. and Agarwal, R.: Tissue distribution of silibinin, the major active constituent

of silymarin, in mice and its association with enhancement of phase II enzymes: Implications in cancer chemoprevention. Carcinogenesis, 20: 2101-2108, 1999.

113. Bhatia, N., Zhao, J., Wolf, D.M. and Agarwal, R.: Inhibition of human carcinoma cell

growth and DNA synthesis by silibinin, an active constituent of milk thistle: comparison with silymarin. Cancer Letts., 147: 77-84, 1999.

114. Zi, X. and Agarwal, R.: Modulation of mitogen-activated protein kinase activation

and cell cycle regulators by the potent skin cancer preventive agent silymarin. Biochem. Biophys. Res. Commun., 263: 528-536, 1999.

115. Zhao, J., Sharma, Y. and Agarwal, R.: Significant inhibition by the flavonoid

antioxidant silymarin against 12-O-tetradecanoylphorbol 13-acetate-caused modulation of antioxidant and inflammatory enzymes, and cyclooxygenase 2 and interlukin-1α expression in SENCAR mouse epidermis: implications in the prevention of stage I tumor promotion. Mol. Carcinogenesis, 26: 321-333, 1999.

116. Zhao, J., Lahiri-Chatterjee, M., Sharma, Y. and Agarwal, R.: Inhibitory effect of a

flavonoid antioxidant silymarin on benzoyl peroxide-induced tumor promotion, oxidative stress and inflammatory responses in SENCAR mouse skin. Carcinogenesis, 21: 811-816, 2000.

117. Agarwal, C., Sharma, Y., Zhao, J. and Agarwal, R.: A polyphenolic fraction from

grape seeds causes irreversible growth inhibition of breast carcinoma MDA-MB468 cells by inhibiting mitogen-activated protein kinases activation and inducing G1 arrest and differentiation. Clinical Cancer Res., 6: 2921-2930, 2000.


41

118. Agarwal, C., Sharma, Y. and Agarwal, R.: Anticarcinogenic effect of a polyphenolic

fraction isolated from grape seeds in human prostate carcinoma DU145 cells: modulation of mitogenic signaling and cell cycle regulators and induction of G1 arrest and apoptosis. Mol. Carcinogenesis, 28: 129-138, 2000.

119. Jiang, C., Agarwal, R. and Lu, J.: Anti-angiogenic potential of silymarin: inhibition of

key attributes of vascular endothelial cells and angiogenic cytokine secretion by cancer epithelial cells. Biochem. Biophys. Res. Commun., 276: 371-378, 2000.

120. Zi, X, Zhang, J., Agarwal, R. and Pollak, M.: Silibinin up-regulates insulin-like

growth factor-binding protein 3 expression and inhibits proliferation of androgen-independent prostate cancer cells. Cancer Res. (Advances in Brief), 60: 5617-5620, 2000.

121. Agarwal, R.: Cell signaling and regulators of cell cycle as molecular targets for

prostate cancer prevention by dietary agents. Biochemical Pharmacol., 60: 1051-1059, 2000.

122. Zi, X., Singh, Rana P. and Agarwal, R.: Impairment of erbB1 receptor and fluid-

phase endocytosis and associated mitogenic signaling by inositol hexaphosphate in human prostate carcinoma DU145 cells. Carcinogenesis, 21: 2225-2235, 2000.

123. Bhatia, N. and Agarwal, R.: Detrimental effect of cancer preventive phytochemicals

silymarin, genistein and epigallocatechin 3-gallate on epigenetic events in human prostate carcinoma DU145 cells. Prostate, 46: 98-107, 2001.

124. Sharma, Y., Agarwal, C., Singh, A.K. and Agarwal, R.: Inhibitory effect of silibinin

on ligand binding to erbB1 and associated mitogenic signaling, growth, and DNA synthesis in advanced human prostate carcinoma cells. Mol. Carcinogenesis, 30: 224-236, 2001.

125. Bhatia, N., Agarwal, C. and Agarwal, R.: Differential response of skin cancer

chemopreventive agent silibinin, quercetin and epigallocatechin 3-gallate on mitogenic signaling and cell cycle regulators in human epidermoid carcinoma A431 cells. Nutrition and Cancer, 39: 292-299, 2001.

After Joining DOPS, SOP, UCHSC 126. Dhanalakshmi, S., Singh, R.P., Agarwal, C and Agarwal, R.: Silibinin inhibits

constitutive and TNFα-induced activation of NF-κB and sensitizes human prostate carcinoma DU145 cells to TNFα-induced apoptosis. Oncogene, 21: 1759-1767, 2002.

127. Tyagi, A., Agarwal, C. and Agarwal, R.: The cancer preventive flavonoid silibinin

causes hypophosphorylation of Rb/p107and Rb2/p130 via modulation of cell cycle regulators in human prostate carcinoma DU145 cells. Cell Cycle, 1: 137-142, 2002.


42

128. Singh, R.P., Tyagi, A.K., Zhao, J. and Agarwal, R.: Silymarin inhibits growth and

causes regression of established skin tumors in SENCAR mice via modulation of mitogen-activated protein kinases and induction of apoptosis. Carcinogenesis, 23: 499-510, 2002.

129. Tyagi, A., Agarwal, C. and Agarwal, R.: Inhibition of Rb phosphorylation at serine

sites and an increase in Rb-E2F complex formation by silibinin in androgen-dependent human prostate carcinoma LNCaP cells: role in prostate cancer prevention. Molecular Cancer Therapeutics, 1: 525-532, 2002.

130. Singh, R.P., Dhanalakshmi, S., Tyagi, A.K., Chan, D.C.F., Agarwal, C. and

Agarwal, R.: Dietary feeding of silibinin inhibits advance human prostate carcinoma growth in athymic nude mice, and increases plasma insulin-like growth factor-binding protein-3 levels. Cancer Res., 62: 3063-3069, 2002.

131. Singh, R.P., Dhanalakshmi, S. and Agarwal, R.: Phytochemicals as cell cycle

modulators: a less toxic approach in halting human cancers. Cell Cycle, 1: 156-161, 2002.

132. Singh, R.P. and Agarwal, R.: Flavonoid antioxidant silymarin and skin cancer.

Antioxidants & Redox Signaling, 4: 655-663, 2002. 133. Tyagi, A., Bhatia, N., Condon, M.S., Bosland, M.C., Agarwal, C. and Agarwal, R.:

Anti-proliferative and apoptotic effects of silibinin in rat prostate cancer cells. Prostate, 53: 211-217, 2002.

134. Jiang, W., Zhu, Z., Bhatia, N., Agarwal, R. and Thompson, H.J.: Mechanisms of

energy restriction: effects of corticosterone on cell growth, cell cycle machinery and apoptosis. Cancer Res., 62: 5280-5287, 2002.

135. Tyagi, A.K., Singh, R.P., Agarwal, C., Chan, D.C.F. and Agarwal, R.: Silibinin

strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth inhibition, G2-M arrest and apoptosis. Clin. Cancer Res., 8: 3512-3519, 2002. (Selected for the commentary – The Biology Behind by Robert S. DiPaola “To arrest or not to G2-M cell cycle arrest, Clin. Cancer Res., 8: 3311-3314, 2002).

136. Agarwal, C., Singh, R.P. and Agarwal, R.: Grape seed extract inhibits growth and

induces apoptotic death of prostate carcinoma DU145 cells via caspases activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release. Carcinogenesis, 23: 1869-1876, 2002.

137. Tyagi, A., Agarwal, R. and Agarwal, C.: Grape seed extract inhibits EGF-induced

and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis. Oncogene, 22: 1302-1316, 2003.


43

138. Singh, R.P., Agarwal, C. and Agarwal, R.: Inositol hexaphosphate inhibits growth,

and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes. Carcinogenesis, 24: 555-563, 2003.

139. Singh, R.P. and Agarwal, R.: Tumor angiogenesis: a potential target in cancer

control by phytochemicals. Current Cancer Drug Targets, 3: 203-215, 2003. 140. Singh, R.P. and Agarwal, R.: Prostate cancer prevention by silibinin. Current

Cancer Drug Targets, 4: 1-11, 2004. 141. Dhanalakshmi, S., Agarwal, P., Glode, L.M. and Agarwal, R.: Silibinin sensitizes

human prostate carcinoma DU145 cells to cisplatin- and carboplatin-induced growth inhibition and apoptotic death. Int. J. Cancer, 106: 699-705, 2003.

142. Sharma, G., Singh, R.P., Chan, D.C.F. and Agarwal, R.: Silibinin induces growth

inhibition and apoptotic cell death in human lung carcinoma cells. Anticancer Res., 23: 2649-2655, 2003.

143. Dhanalakshmi, S., Agarwal, R. and Agarwal, C.: Inhibition of NF-kB pathway in

grape seed extract-induced apoptotic death of human prostate carcinoma DU145 cells. Int. J. Oncology, 23: 721-727, 2003.

144. Singh, R.P., Sharma, G., Dhanalakshmi, S., Agarwal, C. and Agarwal, R.:

Suppression of advanced human prostate tumor growth in nude mice by silibinin feeding is associated with reduced cell proliferation, increased apoptosis, and inhibition of angiogenesis. Cancer Epidemiology, Biomarkers & Prevention, 12: 933-939, 2003.

145. Qi, L., Singh, R.P., Lu, Y., Agarwal, R., Harrison, G.S., Franzusoff, A. and Glode,

L.M.: Epidermal growth factor receptor mediates silibinin-induced cytotoxicity in a rat glioma cell line. Cancer Biology and Therapy, 2: 526-531, 2003.

146. Agarwal, C., Dhanalakshmi, S., Singh, R.P. and Agarwal, R.: Inositol

hexaphosphate inhibits constitutive activation of NF-κB in androgen-independent human prostate carcinoma DU145 cells. Anticancer Res., 23: 3855-3862, 2003.

147. Sharma, G., Singh, R.P. and Agarwal, R.: Growth inhibitory and apoptotic effects of

inositol hexaphosphate in transgenic adenocarcinoma of mouse prostate (TRAMP-C1) cells. Int. J. Oncology, 23: 1413-1418, 2003.

148. Agarwal, C., Singh, R.P., Dhanalakshmi, S., Tyagi, A.K., Tecklenburg, M., Sclafani,

R.A. and Agarwal, R.: Silibinin up-regulates the expression of cyclin-dependent kinase inhibitors, and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells. Oncogene, 22: 8271-8282, 2003.


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149. Tyagi, A.K., Agarwal, C., Singh, R.P., Shroyer, K.R., Glode, L.M. and Agarwal, R.:

Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells. Biochem. Biophys. Res. Commun., 312: 1178-1184, 2003.

150. Dhanalakshmi, S., Mallikarjuna, G.U., Singh, R.P. and Agarwal, R.: Dual-efficacy of

silibinin in protecting or enhancing ultraviolet B radiation-caused apoptosis in human immortalized keratinocyte HaCaT cells. Carcinogenesis, 25: 99-106, 2004.

151. Singh, R.P., Tyagi, A.K., Dhanalakshmi, S., Agarwal, R. and Agarwal, C.: Grape

seed extract inhibits advanced human prostate tumor growth and angiogenesis, and up-regulates insulin-like growth factor binding protein-3. Int. J. Cancer, 108: 733-740, 2004.

152. Singh, R.P., Sharma, G., Mallikarjuna, G.U., Dhanalakshmi, S., Agarwal, C. and

Agarwal, R.: In vivo suppression of hormone-refractory prostate cancer growth by inositol hexaphosphate: induction of insulin-like growth factor binding protein-3 and inhibition of vascular endothelial growth factor. Clinical Cancer Res., 10: 244-250, 2004.

153. Sharma, G., Tyagi, A.K., Singh, R.P., Chan, D.C.F. and Agarwal, R.: Synergistic

anti-cancer effects of grape seed extract and conventional cytotoxic agent doxorubicin against human breast carcinoma cells. Breast Cancer Res. Treatment, 85: 1-12, 2004.

154. Tyagi, A.K., Agarwal, C., Chan, D.C.F. and Agarwal, R.: Synergistic anti-cancer effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinoma MCF-7 and MDA-MB468 cells. Oncology Reports, 11: 493-499, 2004.

155. Agarwal, C., Singh, R.P., Dhanalakshmi, S. and Agarwal, R.: Anti-angiogenic

efficacy of grape seed extract in endothelial cells. Oncology Reports, 11: 681-685, 2004.

156. Dhanalakshmi, S., Mallikarjuna, G.U., Singh, R.P. and Agarwal, R.: Silibinin

prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis. Carcinogenesis, 25: 1459-1465, 2004.

157. Tyagi, A., Agarwal, C., Harrison, G., Glode, L.M. and Agarwal, R.: Silibinin causes

cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages. Carcinogenesis, 25: 1711-1720, 2004.


45

158. Agarwal, C., Dhanalakshmi, S., Singh, R.P. and Agarwal, R.: Inositol Hexaphosphate Inhibits Growth, and Induces G1 Arrest and Apoptotic Death of Androgen-dependent Human Prostate Carcinoma LNCaP Cells. Neoplasia, 6: 646-659, 2004.

159. Mohan, S., Dhanalakshmi, S., Mallikarjuna, G.U., Singh, R.P. and Agarwal, R.:

Silibinin modulates UVB-induced apoptosis via mitochondrial proteins, caspases activation and mitogen-activated protein kinase signaling in human epidermoid carcinoma A431 cells. Biochem. Biophys. Res. Commun., 320: 183-189, 2004.

160. Singh, R.P. and Agarwal, R.: A Cancer Chemopreventive Agent Silibinin, Targets

Mitogenic and Survival Signaling in Prostate Cancer. Mutation Res., 555: 21-32, 2004.

161. Mallikarjuna, G.U., Dhanalakshmi, S., Singh, R.P., Agarwal, C. and Agarwal, R.:

Silibinin Protects against Photocarcinogenesis via Modulation of Cell Cycle Regulators, and Mitogen-Activated Protein Kinases and Akt Signaling. Cancer Res., 64: 6349-6356, 2004.

162. Singh, R.P., Mallikarjuna, G.U., Sharma, G., Dhanalakshmi, S., Tyagi, A.K., Chan,

D.C.F., Agarwal, C. and Agarwal, R.: Oral Silibinin Inhibits Lung Tumor Growth in Athymic Nude Mice and Forms a Novel Chemo-combination with Doxorubicin Targeting NF-κB-mediated Inducible Chemoresistance. Clin. Cancer Res., 10: 8641-8647, 2004.

163. Singh, R.P., Dhanalakshmi, S., Agarwal, C. and Agarwal, R.: Silibinin strongly

inhibits growth and survival of human endothelial cells via cell cycle arrest and down-regulation of survivin, Akt and NF-κB: implications for angioprevention and antiangiogenic therapy. Oncogene, 24: 1188-1202, 2005.

164. Kaur, M., Agarwal, C., Singh, R.P., Guan, X., Dwivedi, C. and Agarwal, R.: Skin

cancer chemopreventive agent, α-santalol, induces apoptotic death of human epidermoid carcinoma A431 cells via caspases activation together with dissipation of mitochondrial membrane potential and cytochrome c release. Carcinogenesis, 26: 369-380, 2005.

165. Yim, D., Singh, R.P., Agarwal, C., Lee, S., Chi, H. and Agarwal, R.: A Novel

Anticancer Agent, Decursin, Induces G1 Arrest and Apoptosis in Human Prostate Carcinoma DU145 Cells. Cancer Res., 65: 1035-1044, 2005.

166. Singh, R.P., Agrawal, P., Yim, D., Agarwal, C. and Agarwal, R.: Acacetin inhibits

cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: structure-activity relationship with linarin and linarin acetate. Carcinogenesis, 26: 845-854, 2005.


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167. Mallikarjuna, G.U., Dhanalakshmi, S., Singh, R.P. and Agarwal, R.: Dietary Feeding of Silibinin Prevents Early Biomarkers of Ultraviolet B Radiation-induced Carcinogenesis in SKH-1 Hairless Mouse Epidermis. Cancer Epidemiology Biomarkers & Prevention, 14: 1344-1349, 2005.

168. Davis-Searles, P.R., Nakanishi, Y., Kim, N.-C., Graf, T.N., Oberlies, N.H., Wani,

M.C., Wall, M.E., Agarwal, R. and Kroll, D.J.: Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on anti-proliferative endpoints in human prostate carcinoma cells. Cancer Res., 65: 4448-4457, 2005.

169. Dhanalakshmi, S., Agarwal, C., Singh, R.P. and Agarwal, R.: Silibinin up-regulates

DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells. J. Biol. Chem., 280: 20375-20383, 2005.

170. Mallikarjuna, G.U., Dhanalakshmi, S., Mohan, S., Singh, R.P. and Agarwal, R.:

Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and associated biological responses in SKH-1 mouse skin. Carcinogenesis Advance Access publication April 14, 2005. Carcinogenesis, 26: 1404-1413, 2005.

171. Singh, R.P. and Agarwal, R.: Mechanisms and preclinical efficacy of silibinin in

preventing skin cancer. Eur. J. Cancer, 41: 1969-1979, 2005. 172. Singh, R.P. and Agarwal, R.: Prostate cancer and inositol hexaphosphate: efficacy

and mechanisms. Anticancer Res., 25: 2891-2903, 2005. 173. Tyagi, A., Singh, R.P., Agarwal, C., Siriwardana, S., Sclafani, R.A. and Agarwal, R.:

Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells. Carcinogenesis, 26:1978-1987, 2005.

174. Varghese, L., Agarwal, C., Tyagi, A., Singh, R.P. and Agarwal, R.: Silibinin efficacy

against human hepatocellular carcinoma. Clin. Cancer Res., 11: 8441-8448, 2005. 175. Deep, G., Singh, R.P., Agarwal, C., Kroll, D.J. and Agarwal, R.: Silymarin and

silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin. Oncogene, 25: 1053-1069, 2006.

176. Singh, R.P. and Agarwal, R.: Natural flavonoids targeting deregulated cell cycle

progression in cancer cells. Current Drug Targets, 7: 345-354, 2006. 177. Veluri, R., Singh, R.P., Liu, Z., Thompson, J.A., Agarwal, R. and Agarwal, C.:

Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and apoptotic death of DU145


47

human prostate carcinoma cells. Carcinogenesis, Advance Access published online on February 10th, 2006. Carcinogenesis, 27: 1445-1453, 2006.

178. Singh, R. P. and Agarwal, R.: Prostate cancer prevention by silibinin – bench to

bedside. Mol. Carcinogenesis, 45: 436-442, 2006. 179. Singh, R.P., Dhanalakshmi, S., Mohan, S., Agarwal, C. and Agarwal, R.: Silibinin

inhibits UVB- and EGF-induced mitogenic and cell survival signaling involving AP-1 and NF-κB in mouse epidermal JB6 cells. Mol. Cancer Therapeutics, 5: 1145-1153, 2006.

180. Kaur, M., Agarwal, R. and Agarwal, C.: Grape Seed Extract induces anoikis and

caspase-mediated apoptosis in human prostate carcinoma LNCaP cells: possible role of ATM-p53 activation. Mol. Cancer Therapeutics, 5: 1265-1274, 2006.

181. Dwivedi, C., Valluri, H.B., Guan, X. and Agarwal, R.: Chemopreventive effects of α-

santalol on UVB-induced skin cancer development. Carcinogenesis, Advance Access published online on May 4th, 2006. Carcinogenesis, 27: 1917-1922, 2006.

182. Singh, R.P., Deep, G., Chittezhath, M., Kaur, M., Dwyer-Nield, L.D., Malkinson, A.M.

and Agarwal, R.: Effect of silibinin on the growth and progression of primary lung tumors in mice. J. Natl. Cancer Inst., 98: 845-855, 2006.

183. Tyagi, A., Singh, R. P., Agarwal, C. and Agarwal, R.: Silibinin activates p53-

caspase-2 pathway and causes caspase-mediated cleavage of cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: an evidence for a regulatory loop between p53 and caspase-2. Carcinogenesis, Advance Access published online on June 15th, 2006. Carcinogenesis, 27: 2269-2280, 2006.

184. Gu, M., Singh, R.P., Dhanalakshmi, S., Mohan, S. and Agarwal, R.: Differential

effect of silibinin on E2F transcription factors and associated biological events in chronically ultraviolet B exposed skin versus tumors in SKH1 hairless mice. Mol. Cancer Therapeutics. 5: 2121-2129, 2006.

185. Singh, R. P. and Agarwal, R.: Mechanisms of action of novel agents for prostate

cancer chemoprevention. Endocrine-Related Cancer, 13: 751-778, 2006. 186. Agarwal, R., Agarwal, C., Ichikawa, H., Singh, R.P. and Aggarwal, B.B.: Anticancer

Potential of Silymarin: From Bench to Bedside and Back. Anticancer Res., 26: 4457-4498, 2006.

187. Kaur, M., Singh, R.P., Gu, M., Agarwal, R. and Agarwal, C.: Grape Seed Extract

Inhibits in Vitro and in Vivo Growth of Human Colorectal Carcinoma Cells. Clin Cancer Res., 12: 6194-6202, 2006. This publication has had an AACR press release entitled “Grape seed extract halts cell cycle, checking growth of colorectal tumors in


48

mice” dated October 18th, 2006. Also featured on Forbes and Rocky Mountain Newspaper.

188. Agarwal, C., Tyagi, A. and Agarwal, R.: Gallic acid causes inactivating

phosphorylation of cdc25A/C-cdc2 via ATM-Chk2 activation, leading to cell cycle arrest, and induces apoptosis in human prostate carcinoma DU145 cells. Mol. Cancer Therapeutics, 5: 3294-3302, 2006.

189. Flaig, T.W., Su, L.-J., Harrison, G., Agarwal, R. and Glodé, L.M.: Silibinin

synergizes with mitoxantrone to inhibit cell growth and induce apoptosis in human prostate cancer cells. Int. J. Cancer, 120: 2028-2033, 2007.

190. Flaig, T.W., Gustafson, D.L., Su, L.-J., Zirrolli, J., Crighton, F., Harrison, G., Pierson,

A. S., Agarwal, R. and Glodé, L.M.: A Phase I and Pharmacokinetic Study of Silybin-Phytosome in prostate cancer patients. Investigational New Drugs, 25: 139-146, 2007.

191. Kaur, M. and Agarwal, R.: Silymarin and epithelial cancer chemoprevention: how

close we are to bedside? Toxicol. Appl. Pharmacol., 224: 350-359, 2007. PMCID: PMC2692696.

192. Kaur, M. and Agarwal, R.: Transcription Factors: Molecular Targets for Prostate

Cancer Intervention by Phytochemicals. Current Cancer Drug Targets, 7: 355-367, 2007.

193. Singh, R.P. and Agarwal, R.: Inducible Nitric Oxide Synthase-Vascular Endothelial

Growth Factor Axis: A Potential Target to Inhibit Tumor Angiogenesis by Dietary Agents. Current Cancer Drug Targets, 7: 475-483, 2007.

194. Gu, M., Singh, R.P., Dhanalakshmi, S., Agarwal, C. and Agarwal, R.: Silibinin

Inhibits Inflammatory and Angiogenic Attributes in Photocarcinogenesis in SKH-1 Hairless Mice. Cancer Res., 67: 3483-3491, 2007.

195. Agarwal, C., Tyagi, A., Kaur, M. and Agarwal, R.: Silibinin inhibits constitutive

activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells. Carcinogenesis, 28: 1463-1470, 2007.

196. Agarwal, C., Veluri, R., Kaur, M., Chou, S.-C., Thompson, J.A. and Agarwal, R.:

Fractionation of high molecular weight tannins in grape seed extract and identification of procyanidin B2-3,3’-di-O-gallate as a major active constituent causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells. Carcinogenesis, 28: 1478-1484, 2007.

197. Deep, G., Oberlies, N.H., Kroll, D.J. and Agarwal, R.: Isosilybin B and isosilybin A

inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells. Carcinogenesis, 28: 1533-1542, 2007.


49

198. Raina, K., Singh, R.P., Agarwal, R. and Agarwal, C.: Oral Grape Seed Extract

Inhibits Prostate Tumor Growth and Progression in TRAMP Mice. Cancer Research, 67: 5976-5982, 2007.

199. Deep, G. and Agarwal, R.: Chemopreventive Efficacy of Silymarin in Skin and

Prostate Cancer. Integrative Cancer Therapies, 6: 130-145, 2007. 200. Raina, K. and Agarwal, R.: Combinatorial Strategies for Cancer Eradication by

Silibinin and Cytotoxic Agents: Efficacy and Mechanisms. Acta Pharmacologica Sinica, 28: 1466-1475, 2007.

201. Velmurugan, B., Agarwal, R. and Singh, R.P.: Role of Bioactive Natural

Compounds in Cancer Control. Phytopharmacology and Therapeutic Values III of the Series Recent Progress in Medicinal Plants, Vol. 21, 383-412, 2007.

202. Roy, S., Kaur, M., Agarwal, C., Tecklenburg, M., Sclafani, R.A. and Agarwal, R.:

P21 and p27 induction by silibinin is essential for its cell cycle arrest effect in prostate carcinoma cells. Mol. Cancer Therapeutics, 6: 2696-2707, 2007.

203. Tyagi, A., Raina, K., Singh, R.P., Gu, M., Agarwal, C., Harrison, G., Glodé, L.M. and

Agarwal, R.: Chemopreventive Effects of Silymarin and Silibinin on N-Butyl-N-(4-hydroxybutyl) Nitrosamine-induced Urinary Bladder Carcinogenesis in Male ICR Mice. Mol. Cancer Therapeutics, 6: 3248-3255, 2007.

204. Raina, K., Blouin, M.J., Singh, R.P., Majeed, N., Deep, G., Varghese, L., Glodé,

L.M., Greenberg, N.M., Hwang, D., Cohen, P., Pollak, M.N. and Agarwal, R.: Dietary Feeding of Silibinin Inhibits Prostate Tumor Growth and Progression in Transgenic Adenocarcinoma of the Mouse Prostate Model. Cancer Research, 67: 11083-11091, 2007.

205. Singh, R.P., Deep, G., Blouin, M.J., Pollak, M.N. and Agarwal, R.: Silibinin

suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft. Carcinogenesis, 28: 2567-2574, 2007.

206. Graf, T.N., Wani, M.C., Agarwal, R., Kroll, D.J. and Oberlies, N.H.: Gram-scale

purification of flavonolignan diastereoisomers from Silybum marianum (milk thistle) in support of preclinical in vivo studies for prostate cancer chemoprevention. Planta Medica, 73: 1495-1501, 2007.

207. Singh, R.P., Tyagi, A., Sharma, G., Mohan, S. and Agarwal, R.: Oral Silibinin

Inhibits In Vivo Human Bladder Tumor Xenograft Growth Involving Down-Regulation of Survivin. Clin. Cancer Res., 14: 300-308, 2008.

208. Anwar, A., Gu, M., Brady, S., Qamar, L., Behbakht, K., Shellman, G.Y., Agarwal,

R., Norris, D.A., Horwitz, L.D. and Fujita. M.: Photoprotective Effects of Bucillamine


50

against UV-Induced skin Damage in a SKH-1 Hairless Mouse Model. Photochemistry Photobiology, 84: 477-483, 2008.

209. Deep, G., Oberlies, N.H., Kroll, D.J. and Agarwal, R.: Identifying the differential

effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells. Int. J. Cancer, 123: 41-50, 2008.

210. Singh, R.P., Gu, M. and Agarwal, R.: Silibinin Inhibits Colorectal Cancer Growth by

Inhibiting Tumor Cell Proliferation and Angiogenesis. Cancer Res., 68: 2043-2050, 2008.

211. Raina, K., Rajamanickam, S., Singh, R.P. and Agarwal, R.: Chemopreventive

Efficacy of Inositol Hexaphosphate against Prostate Tumor Growth and Progression in TRAMP Mice. Clin. Cancer Res., 14: 3177-3184, 2008. PMCID: PMC3049549.

212. Raina, K., Rajamanickam, S., Deep, G., Singh, M., Agarwal, R. and Agarwal, C.:

Chemopreventive Effects of Oral Gallic Acid Feeding on Tumor Growth and Progression in TRAMP Mice. Mol. Cancer Therapeutics, 7: 1258-1267, 2008.

213. Tyagi, A., Sharma, Y., Agarwal, C. and Agarwal, R.: Silibinin Impairs Constitutively

Active TGFα-EGFR Autocrine Loop in Advanced Human Prostate Carcinoma Cells. Pharmaceutical Research, 25: 2143-2150, 2008.

214. Deep, G., Oberlies, N.H., Kroll, D.J. and Agarwal, R.: Isosilybin B causes Androgen

Receptor Degradation in Human Prostate Carcinoma LNCaP and 22Rv1 Cells via PI3K-Akt-Mdm2-Mediated Pathway. Oncogene, 27: 3986-3989, 2008.

215. Ramasamy, K. and Agarwal, R.: Multitargeted therapy of cancer by silymarin.

Cancer Letters, 269: 352-362, 2008. PMCID: PMC2612997. 216. Roy, S., Singh, R.P., Agarwal, C., Siriwardana, S., Sclafani, R. and Agarwal, R.:

Down-regulation of both p21/Cip1 and p27/Kip1 produces a more aggressive prostate cancer phenotype. Cell Cycle, 7: 1828-1835, 2008. PMCID: PMC2744498.

217. Deep, G. and Agarwal, R.: New Combination Therapies with Cell Cycle Agents.

Current Opinion in Investigational Drugs, 9: 591-604, 2008. PMCID: PMC2440501. 218. Velmurugan, B., Singh, R.P., Tyagi, A. and Agarwal, R.: Inhibition of

Azoxymethane-induced Colonic Aberrant Crypt Foci Formation by Silibinin in Male Fisher 344 Rats. Cancer Prevention Research, 1:376-384, 2008. PMCID: PMC2612598.

219. Chittezhath, M., Deep, G., Singh, R.P., Agarwal, C. and Agarwal, R.: Silibinin

inhibits cytokine-induced signaling cascades, and down-regulates inducible nitric oxide synthase in human lung carcinoma A549 cells. Mol. Cancer Therapeutics, 7: 1817-1826, 2008. PMCID: PMC2587409.


51

220. Raina, K., Rajamanickam, S., Singh, R.P., Deep, G., Chittezhath, M. and Agarwal,

R.: Stage Specific Inhibitory Effects and Associated Mechanisms of Silibinin on Tumor Progression and Metastasis in TRAMP Model. Cancer Res., 68: 6822-6830, 2008. PMCID: PMC2587411.

221. Agarwal, R. and Deep, G.: Kava, a Tonic for Relieving the Irrational Development of

Natural Preventive Agents. Perspective. Cancer Prevention Research, 1: 409-412, 2008. PMCID: PMC2675608

222. Deep, G., Oberlies, N.H., Kroll, D.J. and Agarwal, R.: Isosilibinin inhibits advanced

human prostate cancer growth in athymic nude mice: comparison with silymarin and silibinin. Int. J. Cancer, 123: 2750-2758, 2008.

223. Singh, R.P., Raina, K., Sharma, G. and Agarwal, R.: Silibinin Inhibits Established

Prostate Tumor Growth, Progression, Invasion and Metastasis, and Suppresses Tumor Angiogenesis and EMT in TRAMP Mice. Clin. Cancer Res., 14: 7773-7780, 2008. PMCID: PMC2639624

224. Kaur, M., Mandair, R., Agarwal, R. and Agarwal, C.: Grape Seed Extract Induces

Cell Cycle Arrest and Apoptosis in Human Colon Carcinoma Cells. Nutrition & Cancer, 60 (S1): 2-11, 2008. PMCID: PMC2597484

225. Kaur, M., Agarwal, R. and Agarwal, C.: Grape Seed Extract. Encyclopedia of

Cancer, 1297-1301, 2008. (2nd Edition, ed. By M. Schwab). 226. Zhou, L., Gapter, L.A., Ling, H., Zhang, Y., Agarwal, R. and Ng, K.: Cytotoxic and

anti-oxidant activities of lanostane-type triterpenes isolated from Poria cocos. Chem. Pharm. Bull., 56: 1459-1462, 2008.

227. Rajamanickam, S. and Agarwal, R.: Natural products and colon cancer: current

status and future prospects. Drug Development Research, 69: 1-12, 2008. PMCID: PMC2659299

228. Ling, H., Zhou, L., Jia, X., Gapter, L.A., Agarwal, R. and Ng, K.-y.: Polyporenic acid

C induces caspase-8-mediated apoptosis in human lung cancer A549 cells. Mol. Carcinogenesis, 48: 498-507, 2009.

229. Tewari-Singh, N., Rana, S., Gu, M., Pal, A., Orlicky, D.J., White, C.W. and Agarwal,

R.: Inflammatory biomarkers of sulfur mustard analog 2-chloroethyl ethyl sulfide (CEES)-induced skin injury in SKH-1 hairless mice. Toxicological Sciences, 108: 194-206, 2009. PMCID: PMC2644000

230. Tyagi, A., Singh, R.P., Ramasamy, K., Raina, K., Rodente, E.F., Dwyer-Nield, L.D.,

Radcliffe, R.A., Malkinson, A.M. and Agarwal, R.: Growth Inhibition and Regression of Lung Tumors by Silibinin: Modulation of Angiogenesis by Macrophage-associated


52

Cytokines, and NF-κB and STAT3. Cancer Prevention Research, 2: 74-83, 2009. PMCID: PMC2615181

231. Singh, R.P., Raina, K., Deep, G., Chan, D. and Agarwal, R.: Silibinin suppresses

growth of human prostate carcinoma PC-3 orthotopic xenograft via activation of ERK1/2 and inhibition of STAT signaling. Clin. Cancer Res., 15: 613-621, 2009. PMCID: PMC2629529.

232. Roy, S., Gu, M., Ramasamy, K., Singh, R.P., Agarwal, C., Siriwardana, S., Sclafani,

R.A. and Agarwal, R.: P21/Cip1 and P27/Kip1 are Essential Molecular Targets of Inositol Hexaphosphate for Its Antitumor Efficacy against Prostate Cancer. Cancer Res., 69: 1166-1173, 2009. PMCID: PMC2633420.

233. Raina, K., Serkova, N. J. and Agarwal, R.: Silibinin Feeding Alters the Metabolic

Profile in TRAMP Prostatic Tumors: 1H-NMRS-Based Metabolomics Study. Cancer Res. Priority Report, 69: 3731-3735, 2009. PMCID: PMC2679526.

234. Gu, M., Raina, K., Agarwal, C. and Agarwal, R.: Inositol Hexaphosphate Down-

regulates both Constitutive and Ligand-Induced Mitogenic and Cell Survival Signaling, and Causes Caspase-Mediated Apoptotic Death of Human Prostate Carcinoma PC3 cells. Mol. Carcinogenesis, 49: 1-12, 2010. PMCID: PMC2798913.

235. Kaur, M., Agarwal, C. and Agarwal, R.: Anti-cancer and Cancer Chemopreventive

Potential of Grape Seed Extract and Other Grape-based Products. J. Nutrition, 139: 1806S-1812S, 2009. PMCID: PMC2728696.

236. Kaur, M., Balaiya, V., Tyagi, A., Deep, G., Katiyar, S., Agarwal, C. and Agarwal, R.:

Silibinin suppresses growth and induces apoptotic death of human colorectal carcinoma LoVo cells in culture and tumor xenograft. Mol. Cancer Therapeutics, 8: 2366-2374, 2009. PMCID: PMC2728169.

237. Kaur, M., Balaiya, V., Rajamanickam, S., Agarwal, R. and Agarwal, C.: Gallic Acid,

an active constituent of grape seed extract, exhibits anti-proliferative, pro-apoptotic and anti-tumorigenic effects against prostate carcinoma xenograft growth in nude mice. Pharmaceutical Res., 26: 2133-2140, 2009. PMCID: PMC2741017.

238. Singh, R.P. and Agarwal, R.: Cosmeceuticals and Silibinin. Clinics in Dermatology.

27: 479-484, 2009. PMCID: PMC2767273. 239. Rajamanickam, S., Kaur, M., Velmurugan, B., Singh, R.P. and Agarwal, R.: Silibinin

Suppresses Spontaneous Tumorigenesis in APCmin/+ Mouse Model by Modulating Beta-Catenin Pathway. Pharmaceutical Res., 26: 2558-2567, 2009. PMCID: PMC2809789.

240. Pal, A., Tewari-Singh, N., Gu, M., Agarwal, C., Huang, J., Day, B.J., White, C.W.

and Agarwal, R.: Sulfur mustard analog induces oxidative stress and activates


53

signaling cascades in the skin of SKH-1 hairless mice. Free Radical Biol. Med., 47: 1640-1651, 2009. PMCID: PMC2801552.

241. Gu, M., Roy, S., Raina, K., Agarwal, C. and Agarwal, R.: Inositol Hexaphosphate

Suppresses Growth and Induces Apoptosis in Prostate Carcinoma Cells in Culture and Nude Mouse Xenograft: PI3K-Akt Pathway as Potential Target. Cancer Res., 69: 9465-9472, 2009. PMCID: PMC2819750.

242. Kang, T.J., Lee, S.Y., Singh, R.P., Agarwal, R. and Yim, D.S.: Anti-tumor activity of

oxypeucedanin from Ostericum koreanum against human prostate carcinoma DU145 cells. Acta Oncol., 48: 895-900, 2009.

243. Mateen, S., Tyagi, A., Agarwal, C., Singh, R.P. and Agarwal, R.: Silibinin Inhibits Human Non-small Cell Lung Cancer Cell Growth through Cell Cycle Arrest by Modulating Expression and Function of Key Cell Cycle Regulators. Mol. Carcinogenesis, 49: 247-258, 2010. PMCID: PMC3049548

244. Ling, H., Jia, X., Zhang, Y., Gapter, L.A., Lim, Y.S., Agarwal, R. and Ng, K.-y.:

Pachymic acid inhibits cell growth and modulates arachidonic acid metabolism in nonsmall cell lung cancer A549 cells. Mol. Carcinogenesis, 49: 271-282, 2010.

245. Sy-Cordero, A., Graf, T.N., Nakanishi, Y., Wani, M.C., Agarwal, R., Kroll, D.J. and

Oberlies, N.H.: Large-scale Isolation of Flavonolignans from Silybum marianum (Milk Thistle) Extract Affords New Minor Constituents and Preliminary Structure-Activity Relationships. Planta Medica, 76: 644-647, 2010.

246. Velmurugan, B., Singh, R.P., Kaul, N., Agarwal, R. and Agarwal, C.: Dietary feeding

of grape seed extract prevents intestinal tumorigenesis in APCmin/+ mice. Neoplasia, 12: 95-102, 2010. PMCID: PMC2805888.

247. Chou, S.-C., Kaur, M., Thompson, J.T., Agarwal, R. and Agarwal, C.: Influence of

Gallate Esterification on the Activity of Procyanidin B2 in Androgen-dependent Human Prostate Carcinoma LNCaP Cells. Pharmaceutical Res., 27: 619-627, 2010. PMCID: PMC Journal – In Process.

248. Yin, H., Cheng, L., Agarwal, C., Agarwal, R. and Ju, C.: Lactoferrin Protects Against

Concanavalin A-Induced Liver Injury in Mice. Liver International, 30: 623-632, 2010. 249. Flaig, T.W., Glodé, L.M., Gustafson, D., Bokhoven, A.V., Tao, Y., Wilson, S., Su, L.-

J., Yuan, L., Harrison, G., Agarwal, R., Crawford, E.D., Lucia, S. and Pollak, M.: A Pilot Study of High-Dose Oral Silybin-Phytosome Followed by Prostatectomy in Patients with Localized Prostate Cancer. Prostate, 70: 848-855, 2010.

250. Rajamanickam, S., Velmurugan, B., Kaur, M., Singh, R. P., and Agarwal, R.

Chemoprevention of Intestinal tumorigenesis in APC min/+ mice by Silibinin. Cancer Res, 70: 2368-2378, 2010. PMCID: PMC2840193.


54

251. Kaur, M., Velmurugan, B., Tyagi, A., Agarwal, C., Singh, R.P. and Agarwal, R.:

Silibinin Suppresses Growth of Human Colorectal Carcinoma SW480 Cells in Culture and Xenograft via Down-regulation of Beta-catenin-dependent Signaling. Neoplasia, 12: 415-424, 2010. PMCID: PMC2864479.

252. Redente, E.F., Dwyer-Nield, L.D., Merrick, D.T., Raina, K., Agarwal, R., Pao, W.,

Rice, P.L., Shroyer, K.R. and Malkinson, A.M.: Tumor progression stage and anatomical site regulate tumor-associated macrophage and bone marrow-derived monocyte polarization. Am. J. Pathol., 176: 2972-2985, 2010.

253. Velmurugan, B., Singh, R.P., Agarwal, R. and Agarwal, C.: Dietary-feeding of

Grape Seed Extract Prevents Azoxymethane-induced Colonic Aberrant Crypt Foci Formation in Fischer 344 Rats. Mol. Carcinogenesis, 49: 641-652, 2010. PMCID: PMC2892197.

254. Tewari-Singh, N., Gu, M., Agarwal, C., White, C.W. and Agarwal, R.: Biological and

molecular mechanisms of sulfur mustard analog-induced toxicity in JB6 and HaCaT cells: Possible role of ATM/ATR-cell cycle checkpoint pathway. Chem. Res. Toxicol., 23: 1034-1044, 2010. PMCID: PMC2891139.

255. Velmurugan, B., Gangar, S.C., Kaur, M., Tyagi, A., Deep, G. and Agarwal, R.:

Silibinin exerts sustained growth suppressive effect against human colon carcinoma SW480 xenograft by targeting multiple signaling molecules. Pharm. Res., 27: 2085-2097, 2010. PMCID: PMC3085838.

256. Deep, G., Gangar, S.C., Oberlies, N.O., Kroll, D.J. and Agarwal, R.: Isosilybin A

Induces Apoptosis in Human Prostate Cancer Cells via Targeting Akt, NF-κB and Androgen Receptor Signaling. Mol. Carcinogenesis, 49: 902-912, 2010. PMCID: PMC3924888.

257. Deep, G. and Agarwal, R.: Anti-metastatic Efficacy of Silibinin: Molecular

Mechanisms and Therapeutic Potential against Cancer. Cancer Metastasis Reviews, 29: 447-463, 2010. PMCID: PMC3928361.

258. Ravichandran, K., Balaiya Velmurugan, B., Gu, M., Singh, R. P. and Agarwal, R.:

Inhibitory Effect of Silibinin against Azoxymethane-induced Colon Tumorigenesis in A/J Mice. Clin. Cancer Res., 16: 4595-4606, 2010. PMCID: PMC3000041.

259. Tewari-Singh, N., Agarwal, C., Huang, J., Day, B.J., White, C.W. and Agarwal, R.:

Efficacy of glutathione in ameliorating sulfur mustard analog-induced toxicity in cultured skin epidermal cells and in SKH-1 mouse skin in vivo. J. Pharmacol. Exp. Ther., 336: 450-459, 2011. PMCID: PMC 3033716.

260. Ramasamy, K., Dwyer-Nield, L.D., Serkova, N.J., Hasebroock, K.M., Tyagi, A,

Raina, K., Singh, R.P., Malkinson, A.M. and Agarwal, R.: Silibinin Prevents Lung


55

Tumorigenesis in Wild-type but not in iNOS-/- Mice: Potential of Real-time Micro-CT in Lung Cancer Chemoprevention Studies. Clin. Cancer Res., 17: 753-761, 2011. CCR Highlights and cover featured. PMCID: PMC3066181.

261. Kaur, M., Tyagi, A., Singh, R.P., Sclafani, R.A., Agarwal, R. and Agarwal, C.: Grape

seed extract up-regulates p21 (Cip1) through redox-mediated activation of ERK1/2 and post-transcriptional regulation leading to cell cycle arrest in colon carcinoma HT29 cells. Mol. Carcinogenesis, 50: 553-562, 2011; DOI: 10.1002/mc.20739. PMCID: PMC3110540.

262. Jain, A.K., Tewari-Singh, N., Orlicky, D.J., White, C.W. and Agarwal, R.: 2-

Chloroethyl ethyl sulfide causes microvesication and inflammation-related histopathological changes in male hairless mouse skin. Toxicology, 282: 129-138, 2011. PMCID: PMC3085827.

263. Deep, G., Gangar, S.C., Agarwal, C. and Agarwal, R.: Role of E-cadherin in anti-

migratory and anti-invasive efficacy of silibinin in prostate cancer cells. Cancer Prev. Res., 4: 1222-1232, 2011. PMCID: PMC3151351.

264. Jain, A.K., Tewari-Singh, N., Gu, M., Inturi, S., White, C.W. and Agarwal, R.: Sulfur

mustard analog, 2-chloroethyl ethyl sulfide-induced skin injury involves DNA damage and induction of inflammatory mediators, in part via oxidative stress, in SKH-1 hairless mouse skin. Toxicology Letters, 205: 293-301, 2011. PMCID: PMC3207490.

265. Tyagi, A., Gu, M., Takahata, T., Fredrick, B., Agarwal, C., Siriwardana, S., Agarwal,

R. and Sclafani, R.A.: Resveratrol selectively induces DNA damage, independent of Smad4 expression, in its efficacy against human head and neck squamous cell carcinoma. Clin. Cancer Res., 17: 5402-5411, 2011; doi: 10.1158/1078-0432.CCR-11-1072. PMCID: PMC3156958.

266. Kavitha, C.V., Agarwal, C., Agarwal, R. and Deep, G.: Asiatic acid inhibits pro-angiogenic effects of VEGF and human gliomas in endothelial cell culture models. PLOS One, 6: e22745, 2011; DOI: 10.1371/journal.pone.0022745.

267. Inturi, S., Tewari-Singh, N., Gu, M., Shrotriya, S., Gomez, J., Agarwal, C., White,

C.W. and Agarwal, R.: Mechanisms of sulfur mustard analog 2-chloroethyl ethyl sulfide-induced DNA damage in skin epidermal cells and fibroblasts. Free Rad. Biol. Med., 51: 2272-2280, 2011. PMCID: PMC3662483

268. Kale, R.K., Singh, R.P. and Agarwal, R.: Emerging trends in cancer research:

prevention and therapeutics. Preface. Ind. J. Exptl. Biol., 49: 801-802, 2011. 269. Ravichandran, K., Tyagi, A., Deep, G., Agarwal, C. and Agarwal, R.: Interleukin-1β-

induced iNOS Expression in Human Lung Carcinoma A549 Cells: Involvement of STAT and MAPK pathways. Ind. J. Exptl. Biol., 49: 840-847, 2011.


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270. Tyagi, A., Agarwal, C., Dwyer-Nield, L.D., Singh, R.P., Malkinson, A.M. and Agarwal, R.: Silibinin modulates TNF-α and IFN-γ mediated signaling to regulate COX2 and iNOS expression in tumorigenic mouse lung epithelial cells. Mol. Carcinogenesis, 51: 832-842, 2012.

271. Shrestha, S.P., Thompson, J.A., Wempe, M.F., Gu, M., Agarwal, R. and Agarwal, C.: Glucuronidation and Methylation of Procyanidin Dimers B2 and 3,3’’-Di-O-Galloyl-B2 and Corresponding Monomers Epicatechin and 3-O-Galloyl-Epicatechin in Mouse Liver. Pharm. Res., 29: 856-865, 2012. PMCID: PMC3288310

272. Raina, K., Agarwal, C. and Agarwal, R.: Effect of Silibinin in Human Colorectal

Cancer Cells: Targeting the Activation of NF-κB Signaling. Mol. Carcinogenesis, 52: 195-206, 2013. PMCID: PMC3563833

273. Narayanapillai, S., Agarwal, C., Tilley, C. and Agarwal, R.: Silibinin is a Potent Sensitizer of Ultraviolet A Radiation-induced Oxidative Stress and Apoptosis in Human Keratinocyte HaCaT Cells. Photochem. Photobiol., 88: 1135–1140, 2012. PMCID: PMC3925450.

274. Bhat, T.A., Nambiar, D., Pal, A., Agarwal, R. and Singh, R.P.: Fisetin Inhibits

Various Attributes of Angiogenesis in vitro and in vivo – Implications for Angioprevention. Carcinogenesis, 33:385–393, 2012.

275. Roy, S., Deep, G., Agarwal, C. and Agarwal, R.: Silibinin prevents ultraviolet B

radiation-induced epidermal damages in JB6 cells and mouse skin in a p53-GADD45α-dependent manner. Carcinogenesis, 33: 629–636, 2012. PMCID: PMC3384068

276. Shrotriya, S., Deep, G., Gu, M., Kaur, M., Jain, A.K., Inturi, S., Agarwal, R. and Agarwal, C.: Generation of reactive oxygen species by grape seed extract causes irreparable DNA damage leading to G2/M arrest and apoptosis selectively in head and neck squamous cell carcinoma cells. Carcinogenesis, 33: 848–858, 2012. PMCID: PMC3324440

277. Sikka, A., Kaur, M., Agarwal, C., Deep, G. and Agarwal, R.: Metformin Suppresses

Growth of Human Head and Neck Squamous Cell Carcinoma via Global Inhibition of Protein Translation. Cell Cycle, 11:1374-1382, 2012. PMCID: PMC3350878

278. Deep, G., Gangar, S.C., Rajamanickam, S., Raina, K., Gu, M., Agarwal, C., Oberlies, N.H. and Agarwal, R.: Angiopreventive Efficacy of Pure Flavonolignans from Milk Thistle Extract Against Prostate Cancer: Targeting VEGF-VEGFR Signaling. PLoS ONE 7(4): e34630, 2012. PMCID: PMC3326063

279. Shrotriya, S., Deep, G., Ramasamy, K., Raina, K., Barbakadze, V., Merlani, M., Gogilashvili, L., Amiranashvili, L., Mulkijanyan, K., Papadopoulos, K., Agarwal, C. and Agarwal, R.: Poly[3-(3, 4-dihydroxyphenyl) glyceric] acid from Comfrey exerts


57

anti-cancer efficacy against human prostate cancer via targeting androgen receptor, cell cycle arrest and apoptosis. Carcinogenesis, 33: 1572-1580, 2012. PMCID: PMC3499058

280. Tewari-Singh, N., Jain, A.K., Inturi, S., Ammar, D.A., Agarwal, C., Tyagi, P., Kompella, U.B., Enzenauer, R.W., Petrash, J.M. and Agarwal, R.: Silibinin, Dexamethasone, and Doxycycline as Potential Therapeutic Agents for Treating Vesicant-Inflicted Ocular Injuries. Toxicol. Applied Pharmacol., 264: 23-31, 2012. PMCID: PMC3928638.

281. Tewari-Singh, N., Jain, A.K., Inturi, S., Agarwal, C., White, C.W. and Agarwal, R.: Silibinin attenuates sulfur mustard analog-induced skin injury by targeting multiple pathways connecting oxidative stress and inflammation. PLoS ONE, 7(9): e46149, 2012. PMCID: PMC3459894

282. Mateen, S., Raina, K., Jain, A., Agarwal, C., Chan, D. and Agarwal, R.: Epigenetic Modifications and p21-cyclin B1 Nexus in Anti-cancer Effect of Histone Deacetylase Inhibitors in Combination with Silibinin on Non-Small Cell Lung Cancer Cells. Epigenetics, 7: 1161-1172, 2012. PMCID: PMC3469458

283. Henderson, A.J., Ollila, C.A., Kumar, A., Borresen, E.C., Raina, K., Agarwal, R. and Ryan, E.P.: Chemopreventive Properties of Dietary Rice Bran: Current Status and Future Prospects. Advances in Nutrition, 3: 643-653, 2012. PMCID: PMC3648746

284. Figueroa, M., Graf, T.N., Ayers, S., Adcock, A.F., Kroll, D.J., Yang, J., Swanson, S.M., Munoz-Acuna, U., Carcache de Blanco, E.J., Agarwal, R., Wani, M.C., Darveaux, B.A., Pearce, C.J. and Oberlies, N.H.: Cytotoxic Epipolythiodioxopiperazine Alkaloids from Filamentous Fungi of the Bionectriaceae. J. Antibiotics, 65: 559-564, 2012. PMCID: PMC3573876

285. Kavitha, C.V., Deep, G., Gangar, S.C., Jain, A.K., Agarwal, C. and Agarwal, R.: Silibinin inhibits prostate cancer cells- and RANKL-induced osteoclastogenesis by targeting NFATc1, NF-κB and AP-1 activation in RAW264.7 cells. Mol. Carcinogenesis, doi: 10.1002/mc.21959; Oct 31, 2012 [Epub ahead of print]. 53: 169-180, 2014. PMCID: PMC3925459

286. Nambiar, D., Prajapati, V., Agarwal, R. and Singh, R.P.: In vitro and in vivo anticancer efficacy of silibinin against human pancreatic cancer BxPC-3 and PANC-1 cells, Cancer Letters, 334: 109-117, 2013.

287. Raina, R., Ravichandran, K., Rajamanickam, S., Huber, K.M., Serkova, N.J. and Agarwal, R.: Inositol Hexaphosphate Inhibits Tumor Growth, Vascularity, and Metabolism in TRAMP Mice: A Multiparametric Magnetic Resonance Study. Cancer Prev. Res., 6: 40-50, 2013. PMCID: PMC3662486. January 2013 Cancer Prev Res Journal Cover Page Coverage.


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288. Derry, M., Raina, K., Agarwal, R. and Agarwal, C.: Differential Effects of grape seed extract against Human Colorectal Cancer Cell Lines: The Intricate Role of Death receptors and Mitochondria. Cancer Letters, 334: 69-78, 2013. PMCID: PMC3622127.

289. Narayanapillai, S., Agarwal, C., Deep, G. and Agarwal, R.: Silibinin Inhibits Ultraviolet B Radiation-Induced DNA-Damage and Apoptosis by Enhancing Interleukin-12 Expression in JB6 Cells and SKH-1 Hairless Mouse Skin. Mol. Carcinogenesis, DOI 10.1002/mc.22000; Jan 28, 2013 [Epub ahead of print]. 53: 471-479, 2014. PMCID: PMC3883799

290. Sy-Cordero, A.A., Graf, T.N., Runyon, C.P., Wani, M.C., Kroll, D.J., Agarwal, R., Brantley, S.J., Paine, M.F., Polyak, S.J. and Oberlies, N.H.: Enhanced bioactivity of silybin B methylation products. http://dx.doi.org/10.1016/j.bmc.2012.11.035; Bioorganic & Medicinal Chemistry, 21: 742-747, 2013. PMCID: PMC3630461

291. Gažák, R., Fuksová, K., Marhol, P., Kuzma, M., Agarwal, R. and Kren, V.: Preparative method for isosilybin isolation based on enzymatic kinetic resolution of silymarin mixture. Process Biochemistry 48: 184–189, 2013.

292. Raina, K., Agarwal, C., Wadhwa, R., Serkova, N.J. and Agarwal, R.: Energy Deprivation by Silibinin in Colorectal-Cancer Cells: A Double Edged Sword Targeting both Apoptotic and Autophagic Machineries. Autophagy, 9: 697-713, 2013. PMCID: PMC3669180

293. Matten, S., Raina, K., Agarwal, C., Chan, D. and Agarwal, R.: Silibinin Synergizes with Histone Deacetylase and DNA Methyltransferase Inhibitors in Up-regulating E-cadherin Expression Together with Inhibition of Migration and Invasion of Human Non-small Cell Lung Cancer Cells. J. Pharmacol. Exptl. Ther., 345: 206-214, 2013. May 2013 J. Pharmacol. Exptl. Ther. Journal Cover Page Coverage. PMCID: PMC3629797

294. Agarwal, C., Wadhwa, R., Deep, G., Biedermann, D., Gažák, R., Křen, V. and Agarwal, R.: Anti-cancer Efficacy of Silybin Derivatives - A Structure-activity Relationship. PLoS ONE 8(3): e60074. doi:10.1371/journal.pone.0060074, 2013. PMCID: PMC3610875

295. Kaur, M., Deep, G., Jain, A. K., Raina, K., Agarwal, C., Wempe, M. and Agarwal, R.: Bitter melon juice activates cellular energy sensor AMP-activated protein kinase causing apoptotic death of human pancreatic carcinoma cells both in vitro and in vivo. Carcinogenesis, 34:1585-1592, 2013. PMCID: PMC3697895

296. Tyagi, A., Raina, K., Shrestha, S.P., Miller, B., Thompson, T., Wempe, M., Agarwal, R. and Agarwal, C.: Procyanidin B2 3,3″-di-O-gallate, a biologically active constituent of grape seed extract, induces apoptosis in human prostate cancer cells via


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targeting NF-κB, Stat3 and AP1 transcription factors. Nutr & Cancer, 66: 736-746, 2014.

297. Forster, G.M., Raina, K., Kumar, A., Kumar, S., Agarwal, R., Chen, M.-H., Bauer, J.E., McClung, A.M. and Ryan, E.P.: Rice Varietal Differences in Bioactive Bran Components for Inhibition of Colorectal Cancer Cell Growth. Food Chem., 141: 1545-1552, 2013. PMCID: PMC3720235.

298. Mateen, S., Raina, K. and Agarwal, R.: Chemopreventive and Anti-cancer Efficacy of Silibinin against Growth and Progression of Lung Cancer. Nutr & Cancer, 65(S1): 3-11, 2013. PMCID: PMC3924887.

299. Tyagi, A., Raina, K., Gangar, S.C., Kaur, M., Agarwal, R. and Agarwal, C.: Differential Effect of Grape Seed Extract against Human Non-Small-Cell Lung Cancer Cells: the role of Reactive Oxygen Species and Apoptosis Induction. Nutr & Cancer, 65(S1): 44-53, 2013. PMCID: PMC3859370

300. Agarwal, R., Kale, R.K., Rao, C.V. and Singh, R.P.: Introduction to Special issue on Molecular Basis for Cancer Prevention with Bioactive Food Components. (Guest Editors: Agarwal, R., Kale, R.K., Rao, C.V. and Singh, R.P.) Nutrition and Cancer – An International Journal. Nutr & Cancer, 65(S1): 1-2, 2013. PMCID: PMC3808077

301. Ting, H., Deep, G. and Agarwal, R.: Molecular Mechanisms of Silibinin-Mediated Cancer Chemoprevention with Major Emphasis on Prostate Cancer. The AAPS Journal, 15: 707-716, 2013. PMCID: PMC3691417

302. Jain, A.K., Raina, K. and Agarwal, R.: Deletion of p21/Cdkn1a confers protective effect against prostate tumorigenesis in Transgenic Adenocarcinoma of the Mouse Prostate model. Cell Cycle, 12: 1598-1604, 2013. PMCID: PMC3680539

303. Derry, M., Raina, K., Balaiya, V, Jain, A.K., Shrotriya, S., Huber, K.M., Serkova, N.J., Agarwal, R. and Agarwal, C.: Grape Seed Extract Efficacy against Azoxymethane-induced Colon Tumorigenesis in A/J Mice: Interlinking miRNA with Cytokine Signaling and Inflammation. Cancer Prev. Res., 6: 625-633, 2013. PMCID: PMC3701740680539

304. Derry, M.M., Raina, K., Agarwal, C. and Agarwal, R.: Identifying molecular targets of lifestyle modifications in colon cancer prevention. Frontiers in Oncology (Cancer Molecular Targets and Therapeutics), May 2013, Vol 3, Article 119, 1-20; doi: 10.3389/fonc.2013.00119. PMCID: PMC3653120.

305. Raina, K. and Agarwal, R.: Promise and Potential of Silibinin in Colorectal Cancer

Management: what patterns can be seen? Future Oncology, 9: 759-761, 2013. PMCID: PMC3935329


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306. Deep, G. and Agarwal, R.: Targeting Tumor Microenvironment with Silibinin: Promise and Potential for a Translational Cancer Chemopreventive Strategy. Current Cancer Drug Targets, 13:486-499, 2013. PMCID: PMC3924886

307. Tewari-Singh, N., Jain, A.K., Inturi, S., White, C.W. and Agarwal, R.: Clinically-

relevant cutaneous lesions by nitrogen mustard: useful biomarkers of vesicants skin injury in SKH-1 hairless and C57BL/6 mice. PLoS ONE 8(6): e67557. doi:10.1371/journal.pone.0067557, 2013. PMCID: PMC 3691145.

308. Tyagi, A., Deep, G. and Agarwal, R.: Anti-inflammatory efficacy of silibinin: Role in

cancer chemoprevention. Invited review chapter for the book entitled “Inflammation and Cancer: Mechanisms and Dietary Approaches for Cancer Prevention” edited by Dr. Tony Kong, to be published by Taylor and Francis Books, pp401-417, 2013.

309. Raina, K., Tyagi, A., Kumar, D., Agarwal, R. and Agarwal, C.: Role of Oxidative

Stress in Cytotoxicity of Grape Seed Extract in Human Bladder Cancer Cells. Food Chem. Toxicol., 61: 187-195, 2013. PMCID: PMC3851932

310. Inturi, S., Tewari-Singh, N., Jain, A.K., Roy, S., White, C.W. and Agarwal, R.:

Absence of a p53 allele delays nitrogen mustard-induced early apoptosis and inflammation of murine skin. Toxicology, 311: 184-190, 2013. PMCID: PMC3808076

311. Bhat, T.A., Nambiar, D., Tailor, D., Pal, A., Agarwal, R. and Singh, R.P.: Acacetin

inhibits in vitro and in vivo angiogenesis and down-regulates Stat signaling and VEGF expression. Cancer Prev. Res., 6: 1128-1139, 2013. PMCID: PMC3808880

312. Jain, A.K., Tewari-Singh, N., Inturi, S., Orlicky, D.J., White, C.W. and Agarwal, R.:

Histopathological and immunohistochemical evaluation of nitrogen mustard-induced cutaneous effects in SKH-1 hairless and C57BL/6 mice. Experimental and Toxicologic Pathology, 66: 129-138, 2014. PMCID: PMC3923453

313. Shrotriya, S., Agarwal, R. and Sclafani, R.A.: A Perspective on Chemoprevention

by Resveratrol in Head and Neck Squamous Cell Carcinoma. In V. Vasiliou (ed.) Advances in Experimental Medicine and Biology (AEMB), Springer series, Accepted, 2014.

314. Ting, H., Deep, G., Agarwal, C. and Agarwal, R.: The strategies to control prostate

cancer by chemoprevention approaches. Mutat. Res.: Fundam. Mol. Mech. Mutagen, 760: 1-15, 2014. PMCID: PMC3923454

315. Deep, G., Inturi, S. and Agarwal, R.: Methods to Analyze Chemopreventive Effect

of Silibinin on Prostate Cancer Biomarkers Protein Expression. In Ann M. Bode and Zigang Dong (eds.) Cancer Prevention: Dietary Factors and Pharmacology, Methods in Pharmacology and Toxicology, DOI 10.1007/978-1-4614-9227-6_4, Springer Science, NY, pp. 85-105, 2014.


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316. Tewari-Singh, N., Jain, A.K., Orlicky, D.J., White, C.W. and Agarwal, R.: Cutaneous injury-related structural changes and their progression following topical nitrogen mustard exposure in hairless and haired mice. PLoS ONE 9(1): e85402. doi:10.1371/journal.pone.0085402, 2014. PMCID: PMC3885697

317. Ramteke, A., Ting, H., Agarwal, C., Mateen, S., Somasagara, R., Hussain, A.,

Graner, M., Frederick, B., Agarwal, R. and Deep, G.: Exosomes Secreted under Hypoxia Enhance Invasiveness and Stemness of Prostate Cancer Cells by Targeting Adherens Junction Molecules. Mol. Carcinogenesis, 2013 Dec 17. doi: 10.1002/mc.22124. [Epub ahead of print]. PMCID: In Process.

318. Ting, H., Deep, G., Jain, A.K., Cimic, A., Sirintrapun, J., Romero, L.M., Cramer,

S.D., Agarwal, C. and Agarwal, R.: Silibinin Prevents Prostate Cancer Cell-Mediated Differentiation of Naïve Fibroblasts into Cancer-Associated Fibroblast Phenotype by Targeting TGF β2. Mol. Carcinogenesis, 2014 Feb 24. doi: 10.1002/mc.22135. [Epub ahead of print]. PMCID: In Process.

319. Shrotriya, S., Tyagi, A., Deep, G., Orlicky, D.J., Wisell, J., Wang, X.-J., Sclafani,

R.A., Agarwal, R. and Agarwal, C.: Grape seed extract and resveratrol prevent 4-nitroquinoline 1-oxide induced oral tumorigenesis in mice by modulating AMPK activation and associated biological responses. Mol. Carcinogenesis, DOI 10.1002/mc.22099, 2014. PMCID: In Process.

320. Deep, G., Jain, A.K., Ramteke, A., Ting, H., Vijendra, K.C., Gangar, S.C., Agarwal,

C. and Agarwal, R.: SNAI1 is critical for the aggressiveness of prostate cancer cells with low E-cadherin. Molecular Cancer, 13: 37, 2014. PMCID: PMC3937432

321. Derry, M.M., Raina, K., Agarwal, R. and Agarwal, C.: Characterization of

azoxymethane-induced colon tumor metastasis to lung in a mouse model relevant to human sporadic colorectal cancer and evaluation of grape seed extract efficacy. Experimental and Toxicologic Pathology, 66: 235-242, 2014. PMCID: PMC4029844

322. Jain, A.K., Tewari-Singh, N., Inturi, S., Orlicky, D.J., White, C.W. and Agarwal, R.:

Myeloperoxidase deficiency attenuates nitrogen mustard-induced skin injuries. Toxicology, 320: 25-33, 2014. PMCID: PMC4019690

323. Inturi, S., Tewari-Singh, N., Agarwal, C., White, C.W. and Agarwal, R.: Activation of

DNA damage repair pathways in response to nitrogen mustard-induced DNA damage and toxicity in skin keratinocytes. Mutat. Res.: Fundam. Mol. Mech. Mutagen, 763-764: 53-63, 2014.

324. Derry, M.M., Somsagara, R., Raina, K., Gomez, J., Patel, M., Agarwal, R. and

Agarwal, C.: Target Identification of Grape Seed Extract in Colorectal Cancer using Drug Affinity Responsive Target Stability (DARTS) Technique: Role of Endoplasmic Reticulum Stress Response Proteins. Current Cancer Drug Targets, 14: 323-336, 2014.


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325. Tewari-Singh, N., Inturi, S., Jain, A.K., Agarwal, C., Orlicky, D.J., White, C.W.,

Agarwal, R.* and Day, B.J.*: Catalytic antioxidant AEOL 10150 treatment ameliorates sulfur mustard analog 2-chloroethyl ethyl sulfide associated cutaneous toxic effects. Free Rad. Biol. Med., 72: 285-295, 2014. (Equal senior and corresponding authors).

326. Bauerle, K.T., Schweppe, R.E., Lund, G., Kotnis, G., Deep, G., Agarwal, R.,

Pozdeyev, N., Wood, W.M. and Haugen, B.R. Nuclear Factor kappa B-dependent Regulation of Angiogenesis, and Metastasis in an In Vivo Model of Thyroid Cancer is Associated with Secreted Interleukin-8. J. Clin. Endocrinol. Metab., 2014, doi: 10.1210/jc.2013-3636.

327. Deep, G., Kumar, R., Jain, A.K., Agarwal, C. and Agarwal, R.: Silibinin inhibits

fibronectin induced motility, invasiveness and survival in human prostate carcinoma PC3 cells via targeting integrin signaling. Mutat. Res.: Fundam. Mol. Mech. Mutagen, http://dx.doi.org/10.1016/j.mrfmmm.2014.05.002, 2014. PMCID: In Process.


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BOOK CHAPTERS and PROCEEDINGS 1. Agarwal, R. and Mukhtar, H.: Cutaneous chemical carcinogenesis. In Pharmacology

of the Skin, Mukhtar, H. (ed), CRC Press, pp. 371-387, 1991. 2. Mukhtar, H., Agarwal, R. and Bickers, D.R.: Cutaneous metabolism of xenobiotics

and steroid hormones. In Pharmacology of the Skin, Mukhtar, H. (ed), CRC Press, pp. 89-109, 1991.

3. Raza, H., Agarwal, R. and Mukhtar, H.: Cutaneous glutathione S-transferases. In

Pharmacology of the Skin, Mukhtar, H. (ed), CRC Press, pp. 131-137, 1991. 4. Athar, M., Agarwal, R., Bickers, D.R. and Mukhtar, H.: Role of reactive oxygen

species in skin. In Pharmacology of the Skin, Mukhtar, H. (ed), CRC Press, pp. 269-279, 1991.

5. Mukhtar, H., Katiyar, S.K. and Agarwal, R.: Cancer chemoprevention by green tea

polyphenols. Proceedings of the International Symposium on Tea Sciences, Yaminishi, T. and Tomita, I. (eds), pp. 12-16, 1992.

6. Mukhtar, H. and Agarwal, R.: Cytochrome P-450-dependent metabolism of drugs

and carcinogens in skin. In Health Risk Assessment: Dermal and Inhalation Exposure and Absorption of Toxicants, Wang, R.G.M., Knaak, J.B. and Maibach, H.I. (eds), CRC Press, pp. 47-61, 1992.

7. Agarwal, R. and Mukhtar, H.: Chemical carcinogenesis in skin: causation,

mechanism and role of oncogenes. In Health Risk Assessment: Dermal and Inhalation Exposure and Absorption of Toxicants, Wang, R.G.M., Knaak, J.B. and Maibach, H.I. (eds), CRC Press, pp. 291-305, 1992.

8. Agarwal, R. and Mukhtar, H.: Oxidative stress in skin chemical carcinogenesis. In

Oxidative Stress in Dermatology, Fuchs, J. and Packer, L. (eds), Marcel Dekker, Inc., pp. 207-241, 1993.

9. Mukhtar, H., Agarwal, R. and Katiyar, S.K.: Anticarcinogenic and antiinflammatory

effects of green tea in murine skin, Proceedings of the 2nd International Symposium on Green Tea, Seoul, Korea, pp. 33-55, 1993.

10. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Introduction: Sources, occurrence,

nomenclature and carcinogenicity of polycyclic aromatic hydrocarbons. In Handbook of Chromatography: Liquid chromatography of polycyclic aromatic hydrocarbons, Rathore, H.S. (ed), CRC Press, pp. 1-17, 1993.

11. Mukhtar, H., Katiyar, S.K. and Agarwal, R.: Cancer chemoprevention by green tea

components. In Advances in Experimental Medicine and Biology: Diet and Cancer:


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Markers, Prevention and Treatment, Jacobs, M.M. (ed), Plenum Press, Volume 354, pp. 121-132, 1993.

12. Mukhtar, H., Mercurio, M.G. and Agarwal, R.: Murine skin carcinogenesis:

Relevance to humans. In Skin Cancer: Mechanism and Human Relevance, Mukhtar, H. (ed), CRC Press, pp. 3-8, 1994.

13. Agarwal, R., Khan, S.G. and Mukhtar, H.: Ras p21 post-translational processing: An

overview and studies in skin cancer. In Skin Cancer: Mechanism and Human Relevance, Mukhtar, H. (ed), CRC Press, pp. 293-304, 1994.

14. Agarwal, R., Katiyar, S.K. and Mukhtar, H.: Skin cancer chemoprevention by

naturally occurring polyphenols. In Skin Cancer: Mechanism and Human Relevance, Mukhtar, H. (ed), CRC Press, pp. 391-399, 1994.

15. Agarwal, R. and Mukhtar, H.: Cancer chemoprevention by polyphenols in green tea

and artichoke. In Advances in Experimental Medicine and Biology: Dietary Phytochemicals in Cancer Prevention and Treatment, Plenum Press, Volume 401, pp. 35-50, 1996.

16. Lahiri, M., Mukhtar, H. and Agarwal, R.: Reactive intermediates and skin cancer. In

Carcinogenicity: Testing, Predicting, and Interpreting Chemical Effects. Kitchin, K.T. (Ed), Marcel Dekker, Inc., 679-714, 1999.

17. Singh, R.P. and Agarwal, R.: SENCAR mouse skin tumorigenesis model. In Tumor

Models in Cancer Research. Teicher, B.A. (Ed), The Humana Press Inc, Totowa, NJ, pp. 359-380, 2001.

18. Kaur, M., Deep, G. and Agarwal, R.: Silibinin in skin health: Efficacy and

mechanism of action. In Tabor, A. and Blair, R.M. Eds. "Nutritional Cosmetics: Beauty from Within", William Andrew Applied Science Publishers, pp. 501-528, 2009.

19. Singh, R.P. and Agarwal, R.: Prostate Cancer Chemoprevention by Silibinin

Involves Down-regulation of Receptor Tyrosine Kinase Signaling. Proceedings of All India Congress of Zooloy, University of Lucknow, December, 2007, 2009.


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CONFERENCES/SEMINARS/SYMPOSIUMS 1. Agarwal, R., Satsangi, R.K., Shukla, M.K., and Chaudhary, C.: Synthesis and CNS

activity of 4-aryl-1-(p-(3’,4’,5’-tri-substituted benzamido)-benzoyl)-piperazines. Paper presented at XIII Annual Meeting of Indian Pharmacological Society (India) September 1980.

2. Agarwal, R., Satsangi, R.K., and Shukla, M.K.: Synthesis and CNS activity of 3-(4-

(1’-piperazinamido-4- aryl(methyl)- anilinomethyl)- benzoxazolin- 2-ones/ thiones. Paper presented at Convention of Chemists (India), December, 1980.

3. Agarwal, R.: Chemistry and CNS activity of 1-(4-methyl coumarin-7yl)-oxyacetyl-3-

methyl-4-(substituted phenyl) hydrazono/azo-pyrazolin-5-ones. Paper presented at Convention of Chemists (India), December, 1981.

4. Chaudhary, C., Agarwal, R., and Misra, V.S.: Synthesis of 1-(4-morpholino-phenyl)-

2-aryl-4-(3,4-disubstituted benzylidene)-imidazolin-5-ones as CNS active agents. Paper presented at Convention of Chemists (India), December, 1981.

5. Singh, C., Agarwal, R., and Misra, V.S.: Synthesis of 1-(p-substituted phenyl)-2-oxo-

3(o-chlorophenoxy)-4-(2-arylindol-3yl)-azetidines. Paper presented at Convention of Chemists (India), December, 1981.

6. Agarwal, R., Kumar, S., and Mehrotra, N.K.: Fractionation of Jute Batching Oil for

identifying tumour inducing components. Paper presented at IIIrd Annual Convention of Indian Association for Cancer Research, March, 1984.

7. Agarwal, R., Gupta, K.P., Kumar, S., and Mehrotra, N.K.: Ability of fresh and used

industrial crude oil to induce AHH in mo:use epidermis. Paper presented at IVth Annual Conference of Society of Toxicology (India), November, 1984.

8. Mohan, R.R., Agarwal, R., and Misra, V.S.: Synthesis of some newer quinazolines

as pharmacologically active agents. Paper presented at 72nd session of Indian Science Congress Association, January, 1985.

9. Mohan, R.R., Agarwal, C., Agarwal, R., and Misra, V.S.: Indophenazines: A new

class of CNS and anti-inflammatory agents. Paper presented at National Symposium of Newer Trends in Synthetic Heterocyclic Chemistry, February, 1985.

10. Agarwal, R., Kumar, S., Shukla, Y., and Mehrotra, N.K.: A study of tumour initiating

potential of JBO fractions in mouse skin. Paper presented at IVth Annual Convention of Indian Association for Cancer Research, February, 1985.

11. Agarwal, R., Shukla, Y., Kumar, S., and Mehrotra, N.K.: Carcinogenic effect of JBO-

P and its fractions over mouse skin. Paper presented at Vth Annual Conference of Society of Toxicology (India), November, 1985.


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12. Agarwal, R., Kumar, S., Antony, M., and Mehrotra, N.K.: Chemical and biochemical

basis of tumour promoting ability of JBO. Paper presented at Vth Annual Conference of Society of Toxicology (India), November, 1985.

13. Agarwal, R., Bhargava, S.K., Kidwai, M.M., Mehrotra, N.K., and Lal, M.M.:

Estimation of BaP in ambient air of different areas of Lucknow city. Paper presented at National Symposium of chemical carcinogenesis and carcinogens in the environment. December, 1985.

14. Agarwal, R., and Kumar, S.: Protein quality of some vigna unguiculata samples

growing in Manipur. Paper presented at Annual Conference of India Council of Chemists, December, 1987.

15. Agarwal, R., Shukla, Y., Kumar, S., and Mehrotra, N.K.: Tumour initiating potential

of JBO-P and its fractions over mouse skin. Paper presented at Vllth Annual Convention of Indian Association for Cancer Research, February, 1988.

16. Agarwal, R., and Burke, M.: Nucleotide and temperature-induced changes in the

flexibility between SH1 (cys-707) and cys-522 in myosin subfragment 1 probed by crosslinking. FASEB J., 4, A1214, 1990.

17. Agarwal, R., Raza, H., and Mukhtar, H.: Lipoxygenase catalyzed metabolism of the

skin carcinogen BaP in rodent and human epidermis. J. Invest. Dermatol., 94, 502, 1990.

18. Mukhtar, H., Athar, M., Agarwal, R., Elmets, C.A., and Bickers, D.R.:

Chloroaluminum phthalocyanine tetrasulfonate (ALPCTS) photodynamic therapy (PDT) of cutaneous tumors. Photochem. Photobiol., 51 (Suppl), 74S, 1990.

19. Agarwal, R. and Mukhtar, H.: Lipoxygenase catalyzed metabolism of

benzo(a)pyrene and benzo(a)pyrene-7,8-diol in human skin. Toxicologist, 11, 346, 1991.

20. Mukhtar, H., Agarwal, R., Raza, H. and Bickers, D.R.: Glutathione S-transferase-

dependent conjugation of leukotriene A4 to leukotriene C4 in rodent and human skin. FASEB J., 5, A1205, 1991.

21. Agarwal, R., Tafel, J. and Mukhtar, H.: Role of singlet oxygen in in vivo and in vitro

photodestruction of microsomal membranes by chloroaluminum phthalocyanine tetrasulfonate. FASEB J., 5, A1563, 1991.

22. Zaidi, S.I.A., Agarwal, R., Rihter, B.D., Kenney, M.E., Oleinick, N.L. and Mukhtar,

H.: Photoenhancement of lipid peroxidation in human erythrocyte membranes by new silicon phthalocyanines. FASEB J., 5, A1563, 1991.


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23. Agarwal, R., Elmets, C.A., Bickers, D.R. and Mukhtar, H.: Photodynamic therapy of ultraviolet B radiation-induced murine skin tumors by photofrin-II and chloroaluminum phthalocyanine tetrasulfonate. J. Invest. Dermatol., 96, 589 1991.

24. Zaidi, S.I.A., Evans, B.N., Raza, H., Agarwal, R., Ahmad, H., Awasthi, Y.C. and

Mukhtar, H.: Altered expression of glutathione S-transferase isozymes in murine and human skin tumors. J. Invest. Dermatol., 96, 599, 1991.

25. Mukhtar, H., Agarwal, R., Wang, Z.Y. and Bickers, D.R.: Antimutagenic and anti-

tumorigenic activities of nordihydroguaiaretic acid. Proc. Amer. Assoc. Cancer Res., 32, 147, 1991.

26. Agarwal, R. and Mukhtar, H.: Metabolism of benzo(a)pyrene and benzo(a)pyrene

7,8-dihydrodiol catalyzed by human rodent epidermal lipoxygenase. Proc. Amer. Assoc. Cancer Res., 32, 117, 1991.

27. Mukhtar, H., Zaidi, S.I.A., Agarwal, R., Eichler, G., Rihter, B., Kenney, M.E., Clay, M.D., Oleinick, N.L. and Bickers, D.R.: Photodynamic effects of silicon phthalocyanine in Chinese hamster V79 cells and human erythrocyte membranes. Photochem. Photobiol., 53, 93S, 1991.

28. Burke, M. and Agarwal, R.: Substructure of myosin subfragment 1 by photocross-

linking. Location of the cross-link formed in the presence of MgADP from SH1 to the 50-kDa domain. Proc. 15th Int. Congress of Biochem., Jerusalem, Israel, August, 1991, p 163.

29. Mukhtar, H., Katiyar, S.K. and Agarwal, R.: Protection against skin tumor promotion

in SENCAR mice by green tea polyphenols. 2nd Annual Meeting Am. Inst. Cancer Res., Washington, DC, October, 1991.

30. Agarwal, R., Jugert, F.K., Merk, H.F., Bickers, D.R. and Mukhtar, H.: Multiple

cytochrome P-450 isozymes in murine skin: induction by pyridine. FASEB J., 6, A1567, 1992.

31. Jugert, F.K., Agarwal, R., Merk, H.F., Bickers, D.R. and Mukhtar, H.: Induction of

multiple cytochrome P-450 isoenzymes in murine skin by dexamethasone. FASEB J., 6, A1567, 1992.

32. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Inhibition of tumor promoter-caused

induction of epidermal ornithine decarboxylase (ODC) and skin tumor promotion in SENCAR mice by green tea polyphenols. FASEB J., 6, A1495, 1992.

33. Agarwal, R., Katiyar, S.K., Zaidi, S.I.A. and Mukhtar, H.: Inhibition of tumor

promoter-caused epidermal ornithine decarboxylase induction by polyphenolic fraction isolated from green tea. Proc. Amer. Assoc. Cancer Res., 33:168, 1992.


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34. Katiyar, S.K., Agarwal, R., Wang, Z.Y. and Mukhtar, H.: Protection against 12-O-tetradecanoylphorbol-13-acetate-caused tumor promotion in SENCAR mice by polyphenolic fraction from green tea. Proc. Amer. Assoc. Cancer Res., 33:168, 1992.

35. Zaidi, S.I.A., Agarwal, R. and Mukhtar, H.: Expression of glutathione S-transferases

in murine and human skin tumors. Proc. Amer. Assoc. Cancer Res., 33:11, 1992. 36. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Inhibition of tumor promotion in murine

skin by green tea polyphenols. J. Invest. Derm., 98, 663, 1992. 37. Jugert, F.K., Agarwal, R., Merk, H.F., Bickers, D.R. and Mukhtar, H.: Evidence for

the occurrence of multiple cytochrome P-450 isozymes in murine skin: induction by dexamethasone. J. Invest. Derm., 98, 652, 1992.

38. Zaidi, S.I.A., Agarwal, R., Bickers, D.R. and Mukhtar, H.: Mechanism of

photodynamic effects of chloroaluminum phthalocyanine. J. Invest. Derm., 98, 657, 1992.

39. Agarwal, R., Jugert, F.K., Merk, H.F., Bickers, D.R. and Mukhtar, H.: Induction of

cytochrome P-450 isozymes 1A, 2B and 3A in murine skin by pyridine. J. Invest. Derm., 98, 652, 1992.

40. Agarwal, R., Raza, H., Bickers, D.R. and Mukhtar, H.: Biotransformation of

leukotriene A4 to leukotriene C4 by affinity purified glutathione s-transferase from rat skin. Skin Pharmacol., 5, 193, 1992.

41. Jugert, F.K., Agarwal, R., Frankenberg, S., Junginger, H., Bickers, D.R., Mukhtar,

H. and Merk, H.F.: Multiple inducible cytochrome p450 isozymes in human epidermal keratinocytes. Skin Pharmacol., 5, 197, 1992.

42. Jugert, F.K., Agarwal, R., Bickers, D.R., Merk, H.F. and Mukhtar, H.: Induction of

cytochrome P450 subfamilies 1A, 2B, 2E and 3A in murine skin by dexamethasone. Skin Pharmacol., 5, 198, 1992.

43. Katiyar, S.K., Agarwal, R., Wood, G.S. and Mukhtar, H.: Skin cancer

chemoprevention by green tea polyphenols. Skin Pharmacol., 5, 198, 1992. 44. Studer, J.A., Jugert, F.K., Fleming, T.E., Elmets, C.A., Bik, D.P., Agarwal, R. and

Mukhtar, H.: Cytochrome P4501A1-dependent metabolism of skin carcinogen benzo(a)pyrene in human langerhans cells. Skin Pharmacol., 5, 205, 1992.

45. Zaidi, S.I.A., Agarwal, R., Bickers, D.R. and Mukhtar, H.: Photodynamic therapy of

murine skin tumors. Skin Pharmacol., 5, 207, 1992.


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46. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Inhibition of skin tumor promotion by green tea polyphenols: mechanistic studies. Environmental Skin Cancer: Mechanisms, Models and Human Relevance, 1992.

47. Khan, S.G., Bickers, D.R., Mukhtar, H. and Agarwal, R.: Farnesyltransferase activity

and Ha-ras p21 processing during skin tumorigenesis. Environmental Skin Cancer: Mechanisms, Models and Human Relevance, 1992.

48. Zaidi, S.I.A., Agarwal, R., Bickers, D.R. and Mukhtar, H.: First and second

generation photosensitizer-based photodynamic therapy of murine skin tumors. Environmental Skin Cancer: Mechanisms, Models and Human Relevance, 1992.

49. Jugert, F.K., Agarwal, R., Mukhtar, H. and Merk, H.F.: Induction of cytochrome

P450 subfamilies 1A, 2B, 2E and 3A in murine skin by dexamethasone. 13th European Workshop on Drug Metabolism, European Soc. Biochem. Pharmacol., 1992.

50. Studer, J.A., Agarwal, R., Jugert, F.K., Fleming, T.E., Mukhtar, H. and Elmets, C.A.:

Cytochrome P4501A1-dependent metabolism of the skin carcinogen benzo(a)pyrene in human langerhans cells. Central Regional Meeting, Soc. Invest. Dermatol., 1992.

51. Agarwal, R., Khan, S.G., Bickers, D.R. and Mukhtar, H.: Processing of

overexpressed Ha-ras oncoprotein p21 in chemical carcinogen-induced tumors in SENCAR mouse skin. J. Invest. Dermatol., 100:601, 1993.

52. Katiyar, S.K., Agarwal, R., Bickers, D.R. and Mukhtar, H.: Chemopreventive effects

of green tea against stage I and stage II tumor promotion and malignant conversion in SENCAR mouse skin. J. Invest. Dermatol., 100:603, 1993.

53. Mukhtar, H., Katiyar, S.K., Agarwal, R. and Bickers, D.R.: Inhibition of ultraviolet B

radiation-induced inflammatory responses in SKH-1 hairless mice by a polyphenolic fraction isolated from green tea. J. Invest. Dermatol., 100:600, 1993.

54. Khan, S.G., Bickers, D.R., Mukhtar, H. and Agarwal, R.: Farnesylation of Ha-ras

p21 in ultraviolet B radiation-induced tumors in SKH-1 hairless mice. J. Invest. Dermatol., 100:599, 1993.

55. Agarwal, R., Khan, S.G. and Mukhtar, H.: Ha-ras processing during cutaneous

chemical carcinogenesis. Proc. Am. Assoc. Cancer Res., 34:526, 1993. 56. Khan, S.G., Mukhtar, H. and Agarwal, R.: Farnesyltransferase activity in ultraviolet

B (UVB)-induced skin tumors in SKH-1 hairless mice. Proc. Am. Assoc. Cancer Res., 34:526, 1993.


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57. Mukhtar, H., Katiyar, S.K. and Agarwal, R.: Protection against diethylnitrosamine (DEN) and benzo(α)pyrene (BP)-induced forestomach and lung tumorigenesis in A/J mice by green tea. Proc. Am. Assoc. Cancer Res., 34:555, 1993.

58. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Protection against malignant conversion

of mouse skin papillomas to carcinomas by green tea polyphenols. Proc. Am. Assoc. Cancer Res., 34:555, 1993.

59. Agarwal, R., Katiyar, S.K., Khan, S.G. and Mukhtar, H.: Inhibition of ultraviolet B

radiation (UVB)-induced changes in the skin of SKH-1 hairless mice by green tea polyphenols. Photochem. Photobiol., 57:24S, 1993.

60. Mukhtar, H., Katiyar, S.K. and Agarwal, R.: Protection against tumor promoter-induced inflammation in murine skin by green tea polyphenols. 2nd Tricontinental Meeting of JSID, SID and ESDR, Japan, 1992. J. Invest. Dermatol., 101:393, 1993.

61. Agarwal, R., Khan, S.G. and Mukhtar, H.: Ras p21 farnesylation in ultraviolet

radiation-induced tumors in murine skin. 2nd Tricontinental Meeting of JSID, SID and ESDR, Japan, 1992. J. Invest. Dermatol., 101:394, 1993.

62. Mukhtar, H., Katiyar, S.K. and Agarwal, R.: Protective effects of green tea against

12-O-tetradecanoylphorbol-13-acetate- and ultraviolet B radiation-induced inflammation in murine skin. Skin Pharmacol., Abstracts:11, 1993.

63. Agarwal, R., Khan, S.G. and Mukhtar, H.: Ras protein p21 processing in ultraviolet

B radiation-induced tumorigenesis in the skin of SKH-1 hairless mice. Skin Pharmacol., Abstracts:1, 1993.

64. Khan, S.G., Saxena, R., Mukhtar, H. and Agarwal, R.: ras p21 processing

modulates protein kinase C (PKC) isozymes and ornithine decarboxylase (ODC) transcripts: possible role in tumor growth. Proc. Am. Assoc. Cancer Res., 35:616, 1994.

65. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Protection against diethylnitrosamine

(DEN)- and benzo(a)pyrene (BP)-induced forestomach and pulmonary neoplasia in A/J mice by limited oral intubation of green tea polyphenols. Proc. Am. Assoc. Cancer Res., 35:626, 1994.

66. Agarwal, R., Katiyar, S.K., Lundgren, D.W. and Mukhtar, H.: Inhibition of 12-O-

tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity and mRNA in SENCAR mice by silymarin. Proc. Am. Assoc. Cancer Res., 35:626, 1994.

67. Khan, S.G., Saxena, R., Bickers, D.R., Mukhtar, H. and Agarwal, R.: Ras p21 post-

translational processing with membrane localization modulates expression and


71

activation of protein kinase c isozyme z, bII and a: Evidence for a role in tumor growth. J. Invest. Dermatol., 102:548, 1994.

68. Jugert, F.K., Agarwal, R., Mukhtar, H., Bickers, D.R. and Merk, H.F.:

Dexamethasone and cyclosporin A inducible cytochrome P450 3A in murine and human skin. J. Invest. Dermatol., 102:647, 1994.

69. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Inhibition of lipid peroxidation in mouse

epidermal microsomes by epicatechin derivatives from green tea. J. Invest. Dermatol., 102:652, 1994.

70. Agarwal, R., Katiyar, S.K. and Mukhtar, H.: Inhibitory effect of silymarin, an anti-

hepatotoxic flavonoid, on tumor promoter-induced epidermal ornithine decarboxylase activity and mRNA in SENCAR mice. J. Invest. Dermatol., 102:653, 1994.

71. Dummer, R., Siddiqui, J., Khan, S.G., Haffner, A.C., Rupp, C., Bickers, D.R.,

Agarwal, R. and Mukhtar, H.: Human basal cell carcinomas frequently express the gene for farnesyltransferase beta subunit. J. Invest. Dermatol., 102:653, 1994.

72. Dummer, R., Siddiqui, J., Khan, S.G., Haffner, A.C., Rupp, C., Bickers, D.R.,

Agarwal, R. and Mukhtar, H.: Increased farnesylprotein transferase activity in human basal cell carcinomas is associated with beta FTase subunit expression. J. Invest. Dermatol., 103:411, 1994.

73. Mukhtar, H., Agarwal, R. and Katiyar, S.K.: Inhibition of mouse skin tumor

promotion by ethanol extract of ginger root. Proc. Am. Assoc. Cancer Res., 36:594, 1995.

74. Katiyar, S.K., Agarwal, R., Korman, N.J., Rupp, C.O. and Mukhtar, H.: Inhibition of

tumor promoter-caused induction of interleukin-1 (IL-1)-alpha, tumor necrosis factor (TNF)-alpha, and ornithine decarboxylase (ODC) gene expression in SENCAR mouse skin by tea polyphenols. Proc. Am. Assoc. Cancer Res., 36:594, 1995.

75. Agarwal, R., Katiyar, S.K. and Mukhtar, H.: Protection against tumor promotion in

mouse skin by silymarin. Proc. Am. Assoc. Cancer Res., 36:593, 1995. 76. Mohan, R.R., Khan, S.G., Agarwal, R. and Mukhtar, H.: Testosterone induces

ornithine decarboxylase (ODC) activity and mRNA expression in human prostate carcinoma cell line LNCaP: inhibition by green tea. Proc. Am. Assoc. Cancer Res., 36:274, 1995.

77. Khan, S.G., Dummer, R., Siddiqui, J., Agarwal, R. and Mukhtar, H.:

Farnesyltransferase (FTase) activity and gene expression of its α and β subunits in human skin basal cell carcinomas (BCCs). Proc. Am. Assoc. Cancer Res., 36:527, 1995.


72

78. Mukhtar, H., Agarwal, R., Korman, N.J., Rupp, C.O. and Katiyar, S.K.: Inhibition of

tumor promoter-caused induction of epidermal interleukin-1-alpha, tumor necrosis factor-alpha, and ornithine decarboxylase mRNA expression in SENCAR mouse by green tea polyphenols. J. Invest. Dermatol., 104:575, 1995.

79. Katiyar, S.K., Elmets, C.A., Agarwal, R. and Mukhtar, H.: Protection against

ultraviolet B radiation-induced local and systemic suppression of contact hypersensitivity in mice by green tea polyphenols. J. Invest. Dermatol., 104:690, 1995.

80. Agarwal, R., Katiyar, S.K. and Mukhtar, H.: Protective effects of silymarin against

ultraviolet B radiation-induced tumorigenesis in SKH-1 hairless mouse skin. J. Invest. Dermatol., 104:635, 1995.

81. Mohan, R.R., Katiyar, S.K., Mukhtar, H. and Agarwal, R.: Protective effects of

retinoic acid against tumor promotion and progression in low- and high-risk protocols of mouse skin carcinogenesis. J. Invest. Dermatol., 104:574, 1995.

82. Agarwal, R., Katiyar, S.K. and Mukhtar, H.: Protection against photocarcinogenesis

in SKH-1 hairless mice by silymarin. Photochem. Photobiol., 61s:14s, 1995. 83. Mukhtar, H., Korman, N.J., Mohan, R.R., Jawed, S., Zaim, M.T. and Agarwal, R.:

Phthalocyanine-photodynamic therapy of murine skin tumors: Apoptosis is an early event during tumor shrinkage. Photochem. Photobiol., 61s:41s, 1995.

84. Katiyar, S.K., Elmets, C.A., Agarwal, R. and Mukhtar, H.: Polyphenols from green

tea inhibit UVB-caused immune suppression and IL-1a mRNA expression in C3H/HeN mouse skin. Presented at Photocarcinogenesis: Mechanisms, Models and Human Health Implications, October 1995, Washington, D.C. Photodermatol. Photoimmunol. Photomed., 11:234, 1995.

85. Agarwal, R., Katiyar, S.K. and Mukhtar, H.: Protection against photocarcinogenesis

by silymarin. Presented at Photocarcinogenesis: Mechanisms, Models and Human Health Implications, October 1995, Washington, D.C. Photodermatol. Photoimmunol. Photomed., 11:233, 1995.

86. Mohan, R.R., Khan, S.G., Katiyar, S.K., Wood, G.S., Bickers, D.R., Mukhtar, H. and

Agarwal, R.: Ras oncogene mutations are rare event in ultraviolet B radiation-induced tumorigenesis in mouse skin. Presented at Photocarcinogenesis: Mechanisms, Models and Human Health Implications, October 1995, Washington, D.C. Photodermatol. Photoimmunol. Photomed., 11:230, 1995.

87. Lahiri, M., Agarwal, R. and Mukhtar, H.: 32P postlabelling detection of photoproducts

in the epidermis of SKH-1 hairless mice exposed to ultraviolet B radiation. Presented at Photocarcinogenesis: Mechanisms, Models and Human Health


73

Implications, October 1995, Washington, D.C. Photodermatol. Photoimmunol. Photomed., 11:226, 1995.

88. Agarwal, R., Lahiri, M., Mohan, R.R. and Mukhtar, H.: Stage specific anti-tumor

promoting potential of silymarin in mouse skin. Proc. Am. Assoc. Cancer Res., 37:278, 1996.

89. Mukhtar, H., Mohan, R.R., Bostwick, D.G., Amini, S.G. and Agarwal, R.:

Significantly higher ornithine decarboxylase (ODC) activity in human prostate cancer than in normal tissue. Proc. Am. Assoc. Cancer Res., 37:244, 1996.

90. Singh, S.V., Mohan, R.R., Agarwal, R., Benson, P.J., Rudy, M.A., Hu, X., Xia, H., Mack, L.M., Mukhtar, H., Gupta, V., Katoh, A. and Zaren, H.A.: Inhibition of H-ras oncogene transformed tumor cell growth in vivo by diallyl disulfide is associated with inhibition of HMG-Co A reductase activity and ras p21 membrane localization. Proc. Am. Assoc. Cancer Res., 37:391, 1996.

91. Agarwal, R., Lahiri, M., Mohan, R.R. and Mukhtar, H.: Anti-tumor promoting

potential of silymarin against both phorbol and nonphorbol ester type tumor promoter-caused promotion in SENCAR mouse skin. J. Invest. Dermatol., 106:856, 1996.

92. Lahiri, M., Agarwal, R. and Mukhtar, H.: 32P postlabelling assay: a sensitive tool for

detection of ultraviolet B radiation-induced DNA lesions. J. Invest. Dermatol., 106:857, 1996.

93. Katiyar, S.K., Mukhtar, H. and Agarwal, R.: Exceptionally high preventive activity of

silymarin against photocarcinogenesis in mouse skin. Experimental Skin Carcinogenesis Conference, Smithville, TX, October, 1996.

94. Lahiri, M., Agarwal, R. and Mukhtar, H.: Beta-naphthoflavone and 22,3,7,8-

tetrachlorobenzo-p-dioxin inducible cytochrome P450 1B1 in mouse epidermis. Soc. Toxicol., 1997.

95. Agarwal, R., Mohan, R.R., Khan, S.G. and Mukhtar, H.: Bifonazole, an anti-fungal

imidazole, inhibits HMG-CoA reductase followed by ras p21 farnesylation leading to a selective growth inhibition of ras transformed cells. Proc. Am. Assoc. Cancer Res., 38:96, 1997.

96. Zi, X., Feyes, D.K., Mukhtar, H. and Agarwal, R.: Anti-carcinogenic effect of a

polyphenolic antioxidant silymarin in breast cancer cells MDA-MB468: a p53-independent induction of WAF1/Cip1/p21 and G1 arrest. Proc. Am. Assoc. Cancer Res., 38:217, 1997.

97. Gali, H., Ahmad, N., Jawed, S., Mukhtar, H. and Agarwal, R.: Inhibition of epidermal

growth factor receptor (EGFr) tyrosine kinase activity by silymarin, a polyphenolic


74

antioxidant and potent cancer chemopreventive agent. Proc. Am. Assoc. Cancer Res., 38:263, 1997.

98. Ahmad, N., Feyes, D.K., Agarwal, R. and Mukhtar, H.: P53-independent induction of

WAF1/Cip1/p21 regulates the cell cycle mediated apoptosis during photodynamic therapy in human epidermoid carcinoma cells A431. Proc. Am. Assoc. Cancer Res., 38:377, 1997.

99. Mukhtar, H., Ahmad, N., Feyes, D.K. and Agarwal, R.: Green tea polyphenols

induce apoptosis and alter the progression of cell cycle in human epidermoid carcinoma cells A431. Proc. Am. Assoc. Cancer Res., 38:580, 1997.

100. Agarwal, R., Ahmad, N., Javed, S. and Mukhtar, H.: Silymarin, a polyphenolic

antioxidant, exerts its anti-tumor promoting effect by inhibiting epidermal growth factor receptor tyrosine kinase activity. J. Invest. Dermatol., 108:547, 1997.

101. Zi, X., Steele, J.D., Mukhtar, H. and Agarwal, R.: Complete preventive effect of

silymarin against okadaic acid-caused tumor promotion in mouse skin. J. Invest. Dermatol., 108:600, 1997.

102. Mukhtar, H., Ahmad, N., Feyes, D.K. and Agarwal, R.: Cell cycle arrest and

induction of apoptosis in human epidermoid carcinoma cells A431 by green tea polyphenols. J. Invest. Dermatol., 108:600, 1997.

103. Ahmad, N., Feyes, D.K., Agarwal, R. and Mukhtar, H.: Photodynamic therapy

results in WAF1/CIP1/P21-mediated cell cycle arrest in G1-phase followed by apoptosis in human squamous carcinoma cells (A431). J. Invest. Dermatol., 108:667, 1997.

104. Ahmad, N., Feyes, D.K., Agarwal, R. and Mukhtar, H.: WAF1/CIP1/P21 mediates

G1 arrest in cell cycle and apoptosis by photodynamic therapy (PDT). Photochem. Photobiol., 65s:58s, 1997.

105. Zi, X. and Agarwal, R.: Anti-proliferative and apoptotic effects of a potent cancer

preventive agent silymarin are mediated via distinct signals involving respectively ERK and JNK pathways. Proc. Am. Assoc. Cancer Res., 39:291, 1998.

106. Agarwal, R. and Zi, X.: Silymarin decreases prostate specific antigen (PSA)

expression concomitant with inhibition of cell growth, induction of neuroendocrine differentiation and perturbations in cell cycle in human prostate carcinoma cells LNCaP. Proc. Am. Assoc. Cancer Res., 39:320, 1998.

107. Ahmad, N., Agarwal, R. and Mukhtar, H.: Involvement of pRb/p105 and E2F during

photodynamic therapy mediated G0/G1-phase arrest of human epidermoid carcinoma cells A431. Proc. Am. Assoc. Cancer Res., 39:378, 1998.


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108. Agarwal, R.: Skin cancer chemoprevention by a flavonoid antioxidant silymarin. Experimental Skin Carcinogenesis: Third International Meeting, Bastrop, TX, November, 1998.

109. Agarwal, R.: Prostate Cancer Prevention by an antioxidant silymarin. International

Conference on Diet and Prevention of Cancer, Tampere, Finland, June, 1999. 110. Zhao, J., Wang, Z.Y and Agarwal, R.: Biodistribution and sulfate- and

glucuronidate-conjugate formation of a skin cancer chemopreventive agent silymarin in mice. Proc. Am. Assoc. Cancer Res., 40:258, 1999.

111. Bhatia, N., Zi, X. and Agarwal, R.: Enhanced polyphenolic nature of flavonoid

antioxidants plays detrimental role in the activation of survival factor Akt and apoptosis in prostate cancer DU145 cells: a comparison of silymarin, genistein and EGCG. Proc. Am. Assoc. Cancer Res., 40:533, 1999.

112. Chen, L, Zi, X. and Agarwal, R.: Differential impairment of signaling pathways by

skin cancer chemopreventive agents silymarin, quercetin and EGCG: a structure activity response. Proc. Am. Assoc. Cancer Res., 40:533-534, 1999.

113. Zi, X. and Agarwal, R.: Ligand-induced receptor tyrosine kinase endocytosis in

prostate cancer cells. Proc. Am. Assoc. Cancer Res., 40:614, 1999. 114. Jiang, W., Zhu, Z., Bhatia, N., Agarwal, R. and Thompson, H.J.: Corticosterone

treatment of mouse mammary hyperplasia cells TM10 selectively induces G1 arrest via induction of CDKIs and decrease in both CDKs and cyclin D1. Proc. Am. Assoc. Cancer Res., 40:617, 1999.

115. Zi, X. and Agarwal, R.: Impairment of erbB1-mediated endocytosis signaling by

phytic acid: a novel strategy for the secondary prevention of prostate cancer. Proc. Am. Assoc. Cancer Res., 40:654, 1999.

116. Agarwal, R.: Cell signaling, regulators of cell cycle and apoptosis as molecular

targets for prostate cancer intervention by dietary agents. Proc. Signal Transduction Pathways and Regulation of Gene Expression as Therapeutic Targets, Luxembourg, January, 2000.

117. Jiang, C., Agarwal, R. and Lu, J.: Silymarin, a flavonoid phytochemical, inhibts key

angiogenic attributes of vascular endothelial cells. Proc. Am. Assoc. Cancer Res., 41:847, 2000.

118. Agarwal, C., Zhao, J. and Agarwal, R.: Grape seed polyphenols inhibit breast

carcinoma MDA-MB468 cell growth by inhibiting MAPKs, and inducing G1 arrest and differentiation. Proc. Am. Assoc. Cancer Res., 41:532-533, 2000.


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119. Bhatia, N. and Agarwal, R.: Hydrogen peroxide-mediated pro-oxidant activity of epigallocatechin-3 gallate in human prostate carcinoma DU145 cells: effect on cell growth and viability, and MAP kinases. Proc. Am. Assoc. Cancer Res., 41:533, 2000.

120. Bhatia, N., Sharma, Y., Zhao, J. and Agarwal, R.: Therapeutic efficacy of a cancer

preventive agent, silymarin: involvement of anti-proliferative and cell deletion effects via inhibition of mitogenic signaling. Proc. Am. Assoc. Cancer Res., 41:663, 2000.

121. Sharma, Y. and Agarwal, R.: A flavonoid antioxidant silibinin inhibits TGFα

expression and its bining to erbB1 resulting in impairment of ligand/receptor autocrine loop in human prostate carcinoma cells. Proc. Am. Assoc. Cancer Res., 41:846, 2000.

122. Zhao, J., Slaga, T.J. and Agarwal, R.: Inhibition of phorbol ester-caused oxidative

stress and inflammatory responses by a polyphenolic fraction from coffee. Proc. Am. Assoc. Cancer Res., 41:846, 2000.

After Joining DOPS, SOP, UCHSC 123. Singh, R.P., Agarwal, C. and Agarwal, R.: Novel anti-carcinogenic function of

inositol hexaphosphate in human prostate carcinoma DU145 cells: modulation of cell-cycle regulators, growth inhibition, and induction of G1 arrest. Proc. Am. Assoc. Cancer Res., 42:461, 2001.

124. Tyagi, A., Agarwal, C. and Agarwal, R.: Silibinin induces growth inhibition and G1

arrest via induction of CDKIs and decrease in CDKs leading to hypophosphorylation of Rb/p107 in prostate carcinoma DU145 cells. Proc. Am. Assoc. Cancer Res., 42:462, 2001.

125. Agarwal, C., Singh, R.P., Tyagi, A.K. and Agarwal, R.: Anti-carcinogenic effect of

grape seed extract against prostate cancer. Proc. Am. Assoc. Cancer Res., 42:462, 2001.

126. Tyagi, A., Agarwal, C., Chan, D.C. and Agarwal, R.: Strong synergistic efficacy of

silibinin and doxorubicin combination against human prostate carcinoma DU145 cells. Proc. Am. Assoc. Cancer Res., 42:462, 2001.

127. Agarwal, R.: Silymarin and prostate cancer: epigenetic events as molecular targets.

1st Int. Conf. on Mechanisms of Action of Nutraceuticals, October, 2001. 128. Agarwal, C., Dhanalakshmi, S. and Agarwal, R.: Anti-proliferative and apoptotic

effects of sililbinin in human colon cancer HT29 cells: Alterations in cell cycle progression via CDKI induction concomitant with a decrease in kinase activity of CDKs and associated cyclins. Proc. Am. Assoc. Cancer Res., 43:125, 2002.


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129. Singh, R.P., Dhanalakshmi, S., Tyagi, A.K., Chan, D.C.F., Agarwal, C. and Agarwal R.: Dietary feeding of silibinin inhibits advanced human prostate carcinoma growth in athymic nude mice, and increases plasma IGFBP-3 levels. Proc. Am. Assoc. Cancer Res., 43:166, 2002.

130. Dhanalakshmi, S., Agarwal, P., Glode, L.M. and Agarwal, R.: Silibinin sensitizes

DU145 prostate carcinoma cells to cisplatin- and carboplatin-induced growth inhibition and apoptotic cell death. Proc. Am. Assoc. Cancer Res., 43:584, 2002.

131. Tyagi, A.K., Agarwal, R. and Agarwal, C.: Procyanidin B3, isolated from grape seed

extract, induces strong growth inhibition and apoptotic death of human prostrate carcinoma DU145 cells. Proc. Am. Assoc. Cancer Res., 43:641, 2002.

132. Tyagi, A., Agarwal, R. and Agarwal, C.: Grape seed extract inhibits the activation of

both constitutive and EGF-induced MAPK-Elk1-AP1 signaling pathway in human prostrate carcinoma DU145 cells. Proc. Am. Assoc. Cancer Res., 43:642, 2002.

133. Agarwal, C., Singh, R.P. and Agarwal, R.: Grape seed extract-induced apoptotic

death of prostate carcinoma DU145 cells: Involvement of caspases activation via cytochrome C release. Proc. Am. Assoc. Cancer Res., 43:642, 2002.

134. Dhanalakshmi, S., Singh, R.P., Agarwal, C. and Agarwal, R.: Silibinin inhibits

constitutive and TNFα-induced activation of NF-κB and sensitizes human prostate carcinoma DU145 cells to TNFα-induced apoptosis. Proc. Am. Assoc. Cancer Res., 43:642, 2002.

135. Lu, J., Wang, Z., Tyagi, A. and Agarwal, R.: Lack of preventive effect of dietary

silymarin on 1-methyl-1-nitrosourea-induced rat mammary carcinogenesis: Is organ site specificity implied? Proc. Am. Assoc. Cancer Res., 43:823, 2002.

136. Agarwal, R.: Modulation of cell cycle regulators in prostate cancer prevention by

silibinin. The Cell Cycle as a Target in Chemoprevention and Cancer Therapy Conference, 3rd International Conference, Austin, TX, October 2002.

137. Qi, L., Singh, R, Harrison, G.S., Agarwal, R. and Glode, L.M.: The EGF receptor is

necessary and sufficient to mediate silibinin mediated cytotoxicity in transfected 9L glioma cells. ASCO Molecular Therapeutics Symposium, San Diego, CA, November 8-10, 2002.

138. Kim, N.-C., Graf, T. N., Oberlies, N. H., Wani, M. C., Wall, M. E., Agarwal, C.,

Agarwal, R. and Kroll, D. J.: Selective activity of pure flavonolignans from milk thistle (Silibum marianum) against human prostate carcinoma cell lines. Proc. Am. Assoc. Cancer Res., 44:105, 2003.

139. Singh, R.P., Sharma, G., Mallikarjuna, G. U., Dhanalakshmi, S., Agarwal, C. and

Agarwal, R.: Inositol hexaphosphate inhibits advanced human prostate tumor


78

growth and angiogenesis in athymic nude mice. Proc. Am. Assoc. Cancer Res., 44:200, 2003.

140. Agarwal, C., Dhanalakshmi, S., Singh, R. P. and Agarwal, R.: Antiangiogenic effect

of grape seed extract in human prostate cancer xenograft in athymic nude mice. Proc. Am. Assoc. Cancer Res., 44:221, 2003.

141. Tyagi, A. K., Singh, R. P., Agarwal, C., Shroyer, K., Glode, L. M. and Agarwal, R.:

Silibinin down-regulates survivin mRNA and protein expression accompanied by G2-M arrest and apoptosis in human bladder transitional-cell papilloma RT4 cells. Proc. Am. Assoc. Cancer Res., 44:223, 2003.

142. Agarwal, R.: Silibinin and prostate cancer-targeting EGFR. Proc. 21st Annual

Meeting, Mountain West Society of Toxicology – Toxicology and Natural Products. September 2003, Breckenridge, CO.

143. Roy, S., Agarwal, C., Dhanalakshmi, S. and Agarwal, R.: Antiproliferative effect of

inositol hexaphosphate on rat prostate cancer cells. Proc. 21st Annual Meeting, Mountain West Society of Toxicology – Toxicology and Natural Products. September 2003, Breckenridge, CO.

144. Agarwal, R.: Molecular mechanism of silibinin efficacy in prostate cancer. 8th World

Congress on Advances in Oncology, October 2003, Crete, Greece. 145. Majeed, N., Blouin, M.-J., Agarwal, R., Greenberg, N. and Pollak, M.: Oral feeding

of silibinin reduces in vivo prostate cancer incidence and circulating IGF-1 in the TRAMP transgenic model. Proc. Second Annual AACR International Conference on Cancer Prevention Research: Frontiers in Cancer Prevention Research, A183, October 2003, Phoenix, AZ, Cancer Epidemiol. Biomarkers Prev., 12 :1297S-1298S, 2003.

146. Singh, R.P. and Agarwal, R.: Silibinin inhibits growth and causes apoptotic death of

endothelial cells via modulation of survivin and mitochondrial apoptosis. AACR Special Conference on Angiogenesis, October 2003, Chicago, IL.

147. Kaur, M., Agarwal, C., Singh, R.P., Dwivedi, C., Guan, X. and Agarwal, R.: Alpha-

santalol induces apoptotic cell death in human epidermoid carcinoma A431 cells. Proc. Am. Assoc. Cancer Res., 45:167, 2004.

148. Singh, R.P., Agrawal, P., Yim, D. and Agarwal, R.: Growth inhibitory and apoptotic

effects of linarin, linarin acetate and acacetin on human prostate carcinoma cells. Proc. Am. Assoc. Cancer Res., 45:171, 2004.

149. Dhanalakshmi, S., Mohan, S., Singh, R.P., Mallikarjuna, G.U. and Agarwal, R.:

Silibinin enhances UVB-induced apoptosis in human epidermoid carcinoma A431


79

cells via proapoptotic mitochondrial proteins and caspases activation. Proc. Am. Assoc. Cancer Res., 45:315, 2004.

150. Dhanalakshmi, S., Agarwal, C. and Agarwal, R.: Silibinin enhances UVB-induced

MAPK/Erk1/2 activation, p53-ser 15 phosphorylation and accumulation in mouse epidermal JB6 cells: Possible role in protection against photocarcinogenesis. Proc. Am. Assoc. Cancer Res., 45:318-319, 2004.

151. Singh, R.P., Mallikarjuna, G.U., Sharma, G., Dhanalakshmi, S., Tyagi, A., Chan, D.,

Agarwal, C. and Agarwal, R.: Silibinin reduces toxicity and enhances therapeutic efficacy of doxorubicin in lung cancer. Proc. Am. Assoc. Cancer Res., 45:460, 2004.

152. Mallikarjuna, G.U., Dhanalakshmi, S., Singh, R.P., Agarwal, C. and Agarwal, R.:

Protective effects of silibinin against photocarcinogenesis in SKH-1 hairless mice. Proc. Am. Assoc. Cancer Res., 45:513, 2004.

153. Yim, D.S., Singh, R.P., Lee, S.Y., Agarwal, C. and Agarwal, R.: A novel anticancer

agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma DU145 cells. Proc. Am. Assoc. Cancer Res., 45:689, 2004.

154. Tyagi, A., Agarwal, C., Glode, L.M. and Agarwal, R.: Silibinin efficacy in human

bladder transitional cell carcinoma: modulation of cell cycle and apoptosis cascades. Proc. Am. Assoc. Cancer Res., 45:730, 2004.

155. Agarwal, C. and Agarwal, R.: Inositol hexaphosphate inhibits growth, and induces

G1 arrest and apoptotic death of prostate carcinoma LNCaP cells. Proc. Am. Assoc. Cancer Res., 45:902-903, 2004.

156. Dhanalakshmi, S., Mallikarjuna, G.U., Singh, R.P. and Agarwal, R.: Silibinin inhibits

ultraviolet B-caused skin damage via up-regulation of p53 and p21/cip1 in SKH-1 hairless mice. Proc. Am. Assoc. Cancer Res., 45:932-933, 2004 (Mini-symposia).

157. Singh, R.P., Sharma, G., Dhanalakshmi, S., Glode, L.M. and Agarwal, R.: Silibinin

inhibits human bladder transitional-cell papilloma RT4 tumor xenograft growth in athymic nude mice. Proc. Am. Assoc. Cancer Res., 45:1269-1270, 2004.

158. Agarwal, R.: Prostate Cancer Chemoprevention by Silibinin. Proceedings - Dietary

Factors and Cancer Prevention: Current Premises and Future Promises, Rochester, MN, September 23-25, 2004.

159. Agarwal, R.: Prostate Cancer Prevention by IP6: Targeting Cell Cycle Regulation”

Proceedings - IP6 and Cell Signaling in Fighting Cancer: From Laboratory to Clinic Symposium held at the 7th International Conference of Anticancer Research, Corfu, Greece, October 25-30, 2004.


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160. Agarwal, R., Su, L.-J., Flaig, T., Harrison, G.S., Gustafson, D. and Glode, L.M.: A phase I clinical study of silibinin in patients with prosate cancer. Prostate Cancer Foundation (CapCure), October 2004.

161. Agarwal, C., Dhanalakshmi, S. and Agarwal, R.: Silibinin inhibits TNFα-induced NF-

κB activation via IKKα-IκBα pathway in human colon carcinoma cells: possible implications in colorectal cancer prevention and intervention. Proceedings 24th Annual Convention of IACR, New Delhi, India, February 9-12, 2005.

162. Agarwal, R.: IP6 prevents prostate cancer by modulating cell cycle regulators.

Proceedings 24th Annual Convention of IACR, New Delhi, India, February 9-12, 2005.

163. Kaur, M., Agarwal, R. and Agarwal, C.: Grape Seed Extract induces apoptosis in

human prostate carcinoma LNCaP cells: possible roles of anoikis, and mitogen-activated protein kinases and caspases activation. Proc. Am. Assoc. Cancer Res., 46:365, 2005.

164. Agarwal, R., Mallikarjuna, Gu., Dhanalakshmi, S., Mohan, S. and Singh, R.P.:

Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and associated proliferation and apoptosis in SKH-1 mouse skin: implications for the prevention of photocarcinogenesis. Proc. Am. Assoc. Cancer Res., 46:575, 2005.

165. Roy, S., Kaur, M., Agarwal, C., Singh, R.P. and Agarwal, R.: Role of cyclin-

dependent kinase inhibitors p21 and p27 in silibinin-induced G1 arrest in DU145 prostate cancer cells. Proc. Am. Assoc. Cancer Res., 46:575, 2005.

166. Tyagi, A., Agarwal, C. and Agarwal, R.: Silibinin induces apoptosis in human

bladder transitional cell papilloma RT4 cells by activating p53 and Chk2 in an ATM-dependent manner and cleavage of Bid. Proc. Am. Assoc. Cancer Res., 46:575-576, 2005.

167. Deep, G., Singh, R.P., Agarwal, C., Kroll, D.J. and Agarwal, R.: Distinct efficacy of

silibinin in causing G1 and G2-M arrests via cyclins-CDK-CDK inhibitors and Chk2-Cdc25C-Cdc2-cyclin B1 circuitries in human prostate cancer PC3 cells - comparison with crude form silymarin. Proc. Am. Assoc. Cancer Res., 46:576, 2005.

168. Mohan, S., Dhanalakshmi, S., Singh, R.P., Agarwal, C. and Agarwal, R.: Silibinin

inhibits UVB- and EGF-induced mitogenic MAPK-AP1 and cell survival Akt-NF-kB signaling in mouse epidermal JB6 cells: Possible role in protection against skin tumor promotion. Proc. Am. Assoc. Cancer Res., 46:576, 2005.

169. Singh, R.P., Varghese, L., Dhanalakshmi, S. and Agarwal, R.: In vitro as well as in

vivo anticancer efficacy of silibinin against human pancreatic cancer BxPC-3 and Panc-1 cells. Proc. Am. Assoc. Cancer Res., 46:579-580, 2005.


81

170. Mallikarjuna, G.U., Dhanalakshmi, S., Mohan, S., Singh, R.P. and Agarwal, R.: Protective efficacy and associated mechanisms of silibinin against UVB-induced skin tumorigenesis in SKH-1 hairless mice. Proc. Am. Assoc. Cancer Res., 46:1016, 2005.

171. Agarwal, C., Veluri, R., Thompson, J.A. and Agarwal, R.: Biofractionation of GSE:

Identification of gallic acid as one of the major active constituents causing growth inhibition, S phase arrest and apoptotic death of DU145 human prostate carcinoma cells. Proc. Am. Assoc. Cancer Res., 46:1227, 2005.

172. Varghese, L., Agarwal, C., Tyagi, A. and Agarwal, R.: Silibinin induces cell cycle

arrest in human hepatocellular carcinoma HepG2 and Hep3B cells by modulating cyclin-cyclin dependant kinase-cyclin dependant kinase inhibitor levels and activity. Proc. Am. Assoc. Cancer Res., 46:1231-1232, 2005.

173. Chitterzhath, M., Singh, R.P., Agarwal, C. and Agarwal, R.: Silibinin inhibits

cytokines-induced STATs, MAPKs and NF-κB activation and down regulates HIF-1α and iNOS in human lung epithelial A549 cells: Possible role in angioprevention of lung tumorigenesis. Proc. Am. Assoc. Cancer Res., 46:1232, 2005.

174. Flaig, T., Agarwal, R., Su, L.J., Harrison, G.S., Gustafson, D. and Glode, L.M.: A

phase I study of silibinin in hormone refractory prostate cancer. J. Clin. Oncol. 23:427s, 2005.

175. Veluri, R., Agarwal, R., Thompson, J.A. and Agarwal, C.: LC/MS identification of

gallic acid and procyanidins from grape seeds with anti-cancer activity in DU145 human prostate carcinoma cells. Proc. Annual Meeting of the Amer. Chem. Soc., 2005.

176. Agarwal, R.: Prostate cancer prevention by silibinin – bench to bedside.

Proceedings: Targeting Carcinogenesis, Rochester, MN, October 6th to 7th, 2005. 177. Agarwal, R.: Modulation of cell cycle regulators in prostate cancer prevention by

silibinin. Proceedings, 3rd Joint Meeting of the Society for Free Radical Research Australia and Japan, Gold Coast, December 2-5, 2005, page 44.

178. Agarwal, C., Dhanalakshmi, S. and Agarwal, R.: Silibinin inhibits NF-kB activation

via IKKalpha-IkBalpha in human colorectal carcinoma cells. Proceedings, 3rd Joint Meeting of the Society for Free Radical Research Australia and Japan, Gold Coast, December 2-5, 2005, page 128.

179. Flaig, T., Su, L.J., Harrison, G., Agarwal, R. and Glodé, L.M.: Silibinin synergizes

with mitoxantrone to decrease cell viability in prostate cancer cells. ASCO, 2006.


82

180. Kaur, M., Agarwal, R. and Agarwal, C.: Grape seed extract induces cell cycle arrest via up-regulation of p21

Waf1 and down-regulation of cyclins-cyclin dependent kinases,

and causes apoptotic death of human colorectal carcinoma LoVo, HT29 and SW480 cells. Proc. 97th AACR Annual Meeting, Washington, DC, April 1-5, 2006.

181. Raina, K., Katiyar, S., Agarwal, C. and Agarwal, R.: Silibinin inhibits ligand-induced

EGFR and Akt phosphorylation, and causes cell cycle arrest and apoptosis in human colorectal carcinoma SW480 cells. Proc. 97th AACR Annual Meeting, Washington, DC, April 1-5, 2006.

182. Singh, R. P., Sharma, G. and Agarwal, R.: Silibinin consumption inhibits prostate

tumor growth in transgenic adenocarcinoma of mouse prostate (TRAMP) mice. Proc. 97th AACR Annual Meeting, Washington, DC, April 1-5, 2006.

183. Gu, M., Dhanalakshmi, S., Singh, R.P., Agarwal, C. and Agarwal, R.: Silibinin

inhibits UVB-induced skin tumorigenesis by down-regulating STAT3 and NF-κB activation. Proc. 97th AACR Annual Meeting, Washington, DC, April 1-5, 2006.

184. Roy, S. and Agarwal, R.: Protective effect of silibinin against ultraviolet B radiation-

induced apoptosis in mouse epidermal JB6 cells involves prolonged p53 serine15 phosphorylation. Proc. 97th AACR Annual Meeting, Washington, DC, April 1-5, 2006.

185. Deep, G., Oberlies, N.H., Kroll, D.J. and Agarwal, R.: Isosilybin B causes androgen

receptor degradation via PI3K-Akt-Mdm2 pathway leading to a decrease in prostate specific antigen and cell cycle arrest in LNCaP human prostate carcinoma cells. Proc. 97th AACR Annual Meeting, Washington, DC, April 1-5, 2006.

186. Gu, M., Dhanalakshmi, S., Singh, R.P., Agarwal, C. and Agarwal, R.: Inositol

hexaphosphate down-regulates both constitutive and ligand-induced mitogenic and cell survival signaling, and causes caspase-mediated apoptotic death of human prostate carcinoma PC3 cells. Proc. 97th AACR Annual Meeting, Washington, DC, April 1-5, 2006.

187. Tyagi, A., Tyagi, A., Chan, D., Agarwal, C. and Agarwal, R.: Grape seed extract

sensitizes human breast carcinoma cells to chemotherapy agents-induced growth inhibition and apoptotic death via cytochrome c release and caspase activation pathway. Proc. 97th AACR Annual Meeting, Washington, DC, April 1-5, 2006.

188. Agarwal, C., Tyagi, A. and Agarwal, R.: Gallic acid, the major active constituent in

grape seed extract, causes S phase arrest via activation of ATM-Chk1/2-Cdc25A/C-Cdc2 pathway, and leads to caspase-mediated apoptotic death of human prostate carcinoma DU145 cells. Proc. 97th AACR Annual Meeting, Washington, DC, April 1-5, 2006.


83

189. Agarwal, R.: Skin Cancer Prevention by Silibinin. International Conference: Frontiers of Pharmacology and Toxicology, Chicago, IL, August 29th, 2006. Chemico-Biological Intercations, 161: S26, 192-193, 2006.

190. Graf, T.N., Kroll, D.J., Agarwal R., Wani, M.C. and Oberlies, N.H.: Preparation of

large-scale samples of the major bioactive constituents in milk thistle (Silybum marianum (L.) Gaertn.) for preclinical investigations of prostate cancer chemoprevention and treatment. 2006 AACR International Conference on Frontiers in Cancer Prevention Research, Boston, MA.

191. Pappa, A., Milikowsky, J.M., Agarwal, R., Wani, M.C., Oberlies, N.H. and Kroll,

D.J.: Flavonolignans from extracts of milk thistle (Silybum marianum) suppress biomarkers of prostate oncogenesis and colon carcinoma cell proliferation independently of p53 or p21. 2006 AACR International Conference on Frontiers in Cancer Prevention Research, Boston, MA.

192. Agarwal, R.: Molecular mechanism of prostate cancer prevention by a dietary

nutrient inositol hexaphosphate. Proc. of The 3rd APOCP Conference “Empowering Cancer Prevention in the Asian Pacific”, Bangkok, Thailand, November 3-5, 2006.

193. Agarwal, R.: Prostate cancer prevention by silibinin: how close we are to bedside?

International Radiation Oncology Conference Special Session on Cancer Chemoprevention, Varanasi, India, Abstract #180, November 20-22, 2006.

194. Agarwal, C. and Agarwal, R.: Grape seed extract inhibits human colorectal

carcinoma growth by inducing Cip1/p21, cell cycle arrest and apoptosis. International Radiation Oncology Conference Special Session on Cancer Chemoprevention, Varanasi, India, Abstract #179, November 20-22, 2006.

195. Agarwal, R.: Prostate cancer prevention by flavonoid silibinin. 4th Bio/Molecular

Informatics Center International Symposium entitled “Flavonoids: old subjects but new challenges” held at Konkuk University, Seoul, Korea; February 7, 2007.

196. Agarwal, R.: Molecular mechanism of prostate cancer prevention by a dietary

nutrient inositol hexaphosphate” at Natural Products, Diets and Cancer Prevention Session of the American Chemical Society Natioanl Meeting, Chicago, IL. March 25th, 2007.

197. Tewari-Singh, N., Rana, S., Gu, M., Agarwal, C., Day, B.J., White, C.W. and Agarwal,

R.: Biological and Molecular markers for CEES-induced skin injury in JB6 cells. 1st Annual CounterACT Network Research Symposium, April 25-27, 2007, Arlington VA.

198. Rana, S., Tewari-Singh, N., Gu, M., White, C.W. and Agarwal, R.: In Vivo studies to

develop CEES-induced skin toxicity models. 1st Annual CounterACT Network Research Symposium, April 25-27, 2007, Arlington VA.


84

199. Agarwal, C., Veluri, R., Kaur, M., Chou, S.-C., Thompson, J.A. and Agarwal, R.:

Fractionation of high molecular weight tannins in grape seed extract and identification of procyanidin B2-3,3’-di-O-gallate as a major active constituent causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells. Mini-symposium Preclinical Prevention Studies 1: Novel Agents. 2007 AACR Annual Meeting, Los Angeles, CA, April 14-18, 2007.

200. Raina, K., Singh, R. P., Agarwal, R. and Agarwal, C.: Chemoprevention of prostate

cancer by grape seed extract in a transgenic mouse model. 2007 AACR Annual Meeting, Los Angeles, CA, April 14-18, 2007.

201. Agarwal, R., Agarwal, C. and Tyagi, A.: Silibinin inhibits constitutive activation of

Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells. 2007 AACR Annual Meeting, Los Angeles, CA, April 14-18, 2007.

202. Tyagi, A., Singh, R.P., Agarwal, C., Harrison, G., Glode, M.L. and Agarwal, R.:

Chemopreventive effect of silibinin and silymarin on n-butyl-n-(4hydroxybutyl) nitrosamine-induced urinary bladder carcinogenesis in male ICR mice. 2007 AACR Annual Meeting, Los Angeles, CA, April 14-18, 2007.

203. Singh, R.P., Deep, G. and Agarwal, R.: Dietary feeding of silibinin inhibits PC-3

tumor xenograft growth via ERK1/2 activation and an increase in Cip1/p21 and Kip1/p27 expression. 2007 AACR Annual Meeting, Los Angeles, CA, April 14-18, 2007.

204. Deep, G., Oberlies, N.H., Kroll, D.J. and Agarwal, R.: Isosilybin B and isosilybin A

inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells. 2007 AACR Annual Meeting, Los Angeles, CA, April 14-18, 2007.

205. Gu, M., Singh, R. P. and Agarwal, R.: Silibinin inhibits in vivo growth of colorectal

cancer by inhibiting tumor cell proliferation and angiogenesis in athymic nude mice. 2007 AACR Annual Meeting, Los Angeles, CA, April 14-18, 2007.

206. Kaur, M., Agarwal, R. and Agarwal, C.: Gallic acid, a major active constituent of

grape seed extract, induces apoptotic death via the activation of p38 MAPK pathway in human prostate carcinoma DU145 cells. 2007 AACR Annual Meeting, Los Angeles, CA, April 14-18, 2007.

207. Dwyer-Nield, L.D., Singh, R.P., Tyagi, A., Malkinson, A.M. and Agarwal, R.:

Therapeutic efficacy of silibinin on chemically-induced mouse lung tumors. 2007 AACR Annual Meeting, Los Angeles, CA, April 14-18, 2007.


85

208. Roy, S. and Agarwal, R.: Silibinin inhibits apoptosis, reduces DNA lesions and modulates cell cycle events in a p53-dependent manner in ultraviolet B-irradiated mouse epidermal JB6 cells. 2007 AACR Annual Meeting, Los Angeles, CA, April 14-18, 2007.

209. Balaiya, V., Singh, R.P., Tyagi, A. and Agarwal, R.: Inhibition of azoxymethane-

induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats. 2007 AACR Annual Meeting, Los Angeles, CA, April 14-18, 2007.

210. Mateen, S., Tyagi, A. and Agarwal, R.: Anti Cancer Efficacy of Silibinin and Erlotinib

in human Non-small-cell lung cancer cells. 25th Annual Meeting of the Mountain West Society of Toxicology, Breckenridge, CO, September, 2007.

211. Roy, S. and Agarwal, R.: Silibinin protects against UVB-induced damage by

regulating cell cycle events, DNA repair and apoptosis in a P53- and GADD45α-dependent manner. 25th Annual Meeting of the Mountain West Society of Toxicology, Breckenridge, CO, September, 2007.

212. Agarwal, R.: Recent advances in mechanism of cancer chemoprevention by grape

seed extract. 12th World Congress on Advances in Oncology and 10th International Symposium on Molecular Medicine: Bioactive Food Components, Alternative Medicine and Cancer Chemoprevention: Recent Advances. Crete, Greece, October, 2007.

213. Agarwal, R.: Lung cancer chemoprevention by silibinin. 9th International

Conference on Mechanisms of Antimutagenesis and Anticarcinogenesis. Jeju Island, S. Korea, December 1-5, 2007.

214. Agarwal, R.: Chemoprevention of Prostate Cancer by Silibinin: Bench to Bedside.

18th All India Congress of Zoology and SCIAZE, University of Lucknow, Lucknow, India, December 7-9, 2007.

215. Agarwal, R.: Silibinin and Angioprevention – an upcoming strategy. 2nd International

Symposium on Translational Research on Natural Products and Cancer. Lonavala, Mumbai, India, December 9-12, 2007.

216. Pal, A., Agarwal, C., Rana, S., Gu, M., Tewari-Singh, N., White, C.W. and Agarwal,

R.: Sulfur mustard analog-caused activation of signaling cascades in SKH-1 hairless mouse skin. 47th Annual Meeting of Society of Toxicology, Seattle, WA. March 16-20, 2008. Abstract #151.

217. Rana, S., Tewari-Singh, N., Gu, M., Orlicky, D.J., White, C.W. and Agarwal, R.:

Developing in vivo CEES-induced skin toxicity mouse models. 47th Annual Meeting of Society of Toxicology, Seattle, WA. March 16-20, 2008. Abstract #204.


86

218. Tewari-Singh, N., Rana, S., Gu, M., Agarwal, C., White, C.W. and Agarwal, R.: Biological and molecular markers for sulfur mustard analog CEES-induced skin injury in mouse and human epidermal keratinocytes. 47th Annual Meeting of Society of Toxicology, Seattle, WA. March 16-20, 2008. Abstract #678.

219. Mallikarjuna Gu, Chapla Agarwal and Agarwal, R.: Inositol hexaphosphate inhibits

growth and causes apoptotic death of human prostate carcinoma PC3 cells by targeting PI3K-Akt pathway. 99th AACR Annual Meeting, San Diego, CA, April 12-16, 2008. Abstract #1237.

220. Samiha Mateen, Alpna Tyagi, Chapla Agarwal and Agarwal, R.: Anti-cancer activity

of silibinin in human non-small-cell lung cancer cells. 99th AACR Annual Meeting, San Diego, CA, April 12-16, 2008. Abstract #1254.

221. Velmurugan Balaiya, Rana P. Singh, Agarwal, R. and Chapla Agarwal: Inhibition of

azoxymethane-induced colonic aberrant crypt foci formation by grape seed extract in male Fisher 344 rats. 99th AACR Annual Meeting, San Diego, CA, April 12-16, 2008. Abstract #3045.

222. Subapriya Rajamanickam, Komal Raina, Gagan Deep, Meenakshi Singh, Agarwal,

R. and Chapla Agarwal: Chemopreventive effects of oral gallic acid feeding on tumor growth and progression in TRAMP mice. 99th AACR Annual Meeting, San Diego, CA, April 12-16, 2008. Abstract #3046.

223. Manjinder Kaur, Agarwal, R. and Chapla Agarwal: P21 upregulation by grape seed

extract involves generation of reactive oxygen species and sustained activation of ERK1/2 in HT29 cells. 99th AACR Annual Meeting, San Diego, CA, April 12-16, 2008. Abstract #3058.

224. Kumaraguruparan Ramasamy, Alpna Tyagi, Elizabeth Redente, Rana Singh, Lori

Nield, Alvin Malkinson and Agarwal, R.: Chemopreventive potential of silibinin on early urethane-induced lung lesions in A/J mice. 99th AACR Annual Meeting, San Diego, CA, April 12-16, 2008. Abstract #3062.

225. Gagan Deep, Subapriya Rajamanickam, Komal Raina, Gu Mallikarjuna, Nicholas

Oberlies, David Kroll and Agarwal, R.: Isosilybin B inhibits in vitro and in vivo growth of androgen-independent DU145 prostate cancer cells: A comparison with its isomers. 99th AACR Annual Meeting, San Diego, CA, April 12-16, 2008. Abstract #3071.

226. Rana P. Singh, Komal Raina, Gagan Deep, Daniel Chan and Agarwal, R.: Silibinin

suppresses growth of human prostate carcinoma PC-3 orthotopic xenograft via inhibition of STAT and activation of ERK1/2 signaling. 99th AACR Annual Meeting, San Diego, CA, April 12-16, 2008. Abstract #LB-317.


87

227. Komal Raina, Subapriya Rajamanickam and Agarwal, R.: Silibinin inhibits progression and metastasis in TRAMP model by specifically targeting angiogenesis and epithelial-mesenchymal transition. 99th AACR Annual Meeting, San Diego, CA, April 12-16, 2008. Abstract #4658.

228. Komal Raina, Subapriya Rajamanickam, Rana P. Singh and Agarwal, R.: Inositol

hexaphosphate inhibits prostate tumor growth and progression in TRAMP model. 99th AACR Annual Meeting, San Diego, CA, April 12-16, 2008. Abstract #4660.

229. Chapla Agarwal, Velmurugan Balaiya, Rana P. Singh, Nidhi Kaul and Agarwal, R.:

Grape seed extract inhibits intestinal tumorigenesis in APCmin

mice, and decreases COX-2 and iNOS together with an increase in Cip1/p21 level. 99th AACR Annual Meeting, San Diego, CA, April 12-16, 2008. Abstract #4661.

230. Alpna Tyagi, Rana Singh, Kumaraguruparan Ramasamy, Lori Nield, Alvin Malkinson

and Agarwal, R.: Growth inhibition and regression of urethane-induced lung tumors in A/J mice by silibinin: Modulation of angiogenesis by macrophage-associated cytokines and NF-kB and STAT3. 99th AACR Annual Meeting, San Diego, CA, April 12-16, 2008. Abstract #4664.

231. Srirupa Roy, Rana Singh, Chapla Agarwal, Sunitha Siriwardana, Robert Sclafani

and Agarwal, R.: Reduced expression of both p21/Cip1 and p27/Kip1 produces a more aggressive prostate cancer phenotype. 99th AACR Annual Meeting, San Diego, CA, April 12-16, 2008. Abstract #5071.

232. Elizabeth F. Redente, Lori D. Dwyer-Nield, Pamela Rice, Agarwal, R., William Pao,

Jeffrey A. Whitsett, Daniel T. Merrick, Kenneth Shroyer and Alvin M. Malkinson: Signals from solid peripheral tumors alternatively activate bone marrow macrophages before they enter the circulation to associate with tumors. 99th AACR Annual Meeting, San Diego, CA, April 12-16, 2008. Abstract #5343.

233. Agarwal, R.: Molecular Mechanism of Skin Cancer Chemoprevention by Silibinin.

3rd Hormel Institute Symposium Frontiers in Cancer Research and The 8th International Skin Carcinogenesis Conference, The Hormel Institute, Austin, MN. October 4-7, 2008.

234. K Raina, K., Merz, A., Serkova, N.J. and Agarwal, R.: Silibinin Feeding Alters the

Metabolic Profile in TRAMP Prostatic Tumors by 1H-NMRS. Annual Conference of the International Society of Magnetic Resonance in Medicine, 2008.

235. Agarwal, R.: Skin injury models with CEES. SM Symposium, Albuquerque, NM.

November 5-7, 2008. 236. Agarwal, R.: Lung cancer chemoprevention by silibinin. L.S. Skaggs Biomedical

Research Symposium, University of Utah, Salt Lake City, UT. November 10-11, 2008.


88

237. Agarwal, R.: Recent advances in cancer prevention by grape seed extract. NGWI

Grape Health Workshop, San Francisco, CA. December 2-3, 2008. 238. Sclafani, R.A., Agarwal, R., Tyagi, A., Siriwardana, S., Frederick, B., Raben, D. and

Jimeno, A.: Potentiation of Radiation Therapy by Resveratrol and Other Stilbenes. International Symposium on “Novel Strategies for Targeted Prevention and Treatment of Cancer” at the School of Life Sciences, JNU, New Delhi, India, December 19-20, 2008.

239. Ng, K.-Y., Ling, H., Li, W., Gapter, L., Zhou, L., Zhang, Y., Jia, X. and Agarwal, R.:

Anticancer and formulation study of cyclic triterpenes from Poria Cocos. International Symposium on “Novel Strategies for Targeted Prevention and Treatment of Cancer” at the School of Life Sciences, JNU, New Delhi, India, December 19-20, 2008.

240. Tariq, B., Pal, A., Agarwal, R. and Singh, R.P.: Fisetin - a promising antiangiogenic

phytochemical. International Symposium on “Novel Strategies for Targeted Prevention and Treatment of Cancer” at the School of Life Sciences, JNU, New Delhi, India, December 19-20, 2008.

241. Deep, G., Oberlies, N.H., Kroll, D.J. and Agarwal, R.: Isosilybin B Targets

Epithelial-to-Mesenchymal Transition (EMT) and Invasive Potential of Advanced Hormone Refractory Prostate Cancer C4-2B Cells. AACR Advances in Prostate Cancer Research Special Conference, January 21– 24, 2009, San Diego, CA.

242. Inturi, Swetha; Tewari-Singh, Neera; Agarwal, Chapla; White, Carl W and Agarwal,

R.: Quantitative assessment of DNA damage via comet assay in CEES-treated mouse skin epidermal cells and fibroblasts. 48th Annual Meeting of Society of Toxicology, Baltimore, Maryland. March 15-19, 2009.

243. Pal, Arttatrana; Tewari-Singh, Neera; Gu, Mallikarjuna; White, Carl W and Agarwal,

R.: Exposure to CEES induces oxidative stress and produces an inflammatory response in SKH-1 hairless mouse skin. 48th Annual Meeting of Society of Toxicology, Baltimore, Maryland. March 15-19, 2009.

244. Tewari-Singh, Neera; Gu, Mallikarjuna; Pal, Arttatrana; Agarwal, Chapla; White, Carl

W. and Agarwal, R.: Prophylactic and therapeutic efficacy of glutathione (GSH) against sulfur mustard analog CEES-induced skin injury. 48th Annual Meeting of Society of Toxicology, Baltimore, Maryland. March 15-19, 2009.

245. Agarwal, R.: Antiangiogenic efficacy of silibinin in various epithelial tumor models -

a major step forward in Cancer Angioprevention Research. Conference entitled “Inhibitors of angiogenesis: design, synthesis and biological exploitation (ANGIOKEM)”. Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, April 2-4, 2009.


89

246. Agarwal, R.: Develop CEES-induced skin toxicity models, and evaluate silibinin efficacy. Oral Presentation at the 3rd Annual CounterACT Network Research Symposium, Washington, DC. April 14-16, 2009.

247. Tewari-Singh, Neera; Inturi, Swetha; White, Carl W. and Agarwal, R.: Develop

CEES-induced skin toxicity models and evaluate agent efficacy. Poster Presentation at the 3rd Annual CounterACT Network Research Symposium, Washington, DC. April 14-16, 2009.

248. Gagan Deep, Nicholas H. Oberlies, David J. Kroll and Agarwal, R.: Isosilybin A

inhibits survival signaling and induces apoptosis in human prostate cancer cells. AACR 100th Annual Meeting, April 18-22, 2009 Denver, CO. Abstract #17.

249. Chapla Agarwal, Velmurugan Balaiya, Manjinder Kaur and Agarwal, R.: Grape

seed extract inhibits the growth of human head and neck carcinoma cells under both in vitro and in vivo conditions. AACR 100th Annual Meeting, April 18-22, 2009 Denver, CO. Abstract #41.

250. Sangeeta Shrotriya, Gagan Deep, Natasha Walia, Vakhtang Barbakadze, Karen

Mulkijanyan, Maia Merlani, Kyriakos Papadopoulos, Lali Gogilashvili, Lela Amiranashvili, Eka Shaburishvili and Agarwal, R.: Anti-cancer efficacy of novel polymer from caucasian species of comfrey and its synthetic monomer against androgen-dependent and independent human prostate cancer cells. AACR 100th Annual Meeting, April 18-22, 2009 Denver, CO. Abstract #921.

251. Velmurugan Balaiya, Manjinder Kaur, Alpna Tyagi, Suchitra Katiyar, Chapla

Agarwal and Agarwal, R.: Silibinin, an active ingredient of milk thistle extract inhibits the growth of human colorectal carcinoma LoVo cells by causing cell cycle arrest and apoptosis. AACR 100th Annual Meeting, April 18-22, 2009 Denver, CO. Abstract #924.

252. Komal Raina, Natalie J. Serkova and Agarwal, R.: Silibinin feeding alters the

metabolic rofile in TRAMP prostatic tumors: 1H-NMRS-based metabolomics study.

AACR 100th Annual Meeting, April 18-22, 2009 Denver, CO. Abstract #942. 253. Manjinder Kaur, Alpna Tyagi, Suchitra Katiyar, Chapla Agarwal and Agarwal, R.:

Silibinin inhibits the proliferation of human colorectal carcinoma SW480 cells via cell cycle arrest and down regulation of beta-catenin dependent signaling. AACR 100th Annual Meeting, April 18-22, 2009 Denver, CO. Abstract #962.

254. Subapriya Rajamanickam, Balaiya Velmurugan and Agarwal, R.: Silibinin inhibits

intestinal tumorigenesis in APC min/+

mice, an animal model of human familial adenomatous polyposis. AACR 100th Annual Meeting, April 18-22, 2009 Denver, CO. Abstract #2090.


90

255. Subapriya Rajamanickam, Manjinder Kaur, Balaiya Velmurugan and Agarwal, R.: Silibinin inhibits spontaneous intestinal tumorigenesis in the APC

min/+ mice model by

modulating beta-catenin pathway. AACR 100th Annual Meeting, April 18-22, 2009 Denver, CO. Abstract #2100.

256. Dong Sool Yim, Sook Yeon Lee, Rana P. Singh, Gagan Deep and Agarwal, R.:

Efficacy of novel furanocoumarins from Ostericum koreanum against advanced human prostate cancer DU145 cells. AACR 100th Annual Meeting, April 18-22, 2009 Denver, CO. Abstract #2655.

257. Mallikarjuna Gu, Srirupa Roy, Komal Raina, Chapla Agarwal and Agarwal, R.:

Inositol hexaphosphate inhibits human prostate carcinoma PC3 growth by targeting PI3K/Akt/GSK-3α/β pathway. AACR 100th Annual Meeting, April 18-22, 2009 Denver, CO. Abstract #2972.

258. Robert A. Sclafani, Sunitha Siriwardana, Barbara Frederick, Simone Stahringer,

Alpna Tyagi, Antonio Jimeno, Agarwal, R. and David Raben. Combined Resveratrol and radiation therapy in head and neck cancer. AACR 100th Annual Meeting, April 18-22, 2009 Denver, CO. Abstract #3989.

259. Kameswaran Ravichandran, Alpna Tyagi, Chapla Agarwal and Agarwal, R.:

Interleukin-1β induced iNOS expression is independent of MAPK and JAK-STAT pathways in human non small cell lung carcinoma A549 cells. AACR 100th Annual Meeting, April 18-22, 2009 Denver, CO. Abstract #4428.

260. Thomas W. Flaig, L. Michael Glode, Daniel Gustafson, Adrie Van Bokhoven,

Yuzhen Tao, Shandra Wilson, Lih-Jen Su, Yuan Li, Gail Harrison, Agarwal, R., E. David Crawford, M. Scott Lucia and Michael Pollak. A pilot study of oral silybin-phytosome followed by prostatectomy in patients with localized prostate cancer. AACR 100th Annual Meeting, April 18-22, 2009 Denver, CO. Abstract #4510.

261. Alpna Tyagi, Chapla Agarwal, Lori Nield, Alvin Malkinson and Agarwal, R.:

Cytokines TNF-α plus IFN-γ activate multiple signaling pathways regulating the expression of COX2 and iNOS in tumorigenic mouse lung epithelial cells. AACR 100th Annual Meeting, April 18-22, 2009 Denver, CO. Abstract #5270.

262. Agarwal, R.: Molecular Mechanism of Cell Death by Silibinin in colon cancer:

Apoptosis versus Autophagy, at the Symposium Apoptosis: Mechanisms of cell death and therapeutic implications. Faculty of Allied Health Sciences and UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia, July 8th, 2009.

263. Agarwal, R.: Skin Cancer Chemoprevention by Silibinin, at the 7th COSTAM/SFRR

(ASIA/MALAYSIA) International Worshop – Chemoprevention and Translational Research, July 9-12, 2009, Langkawi, Malaysia.


91

264. Tewari-Singh, Neera; Jain, Anil K; Inturi, Swetha and Agarwal, R.: Efficacy studies with silibinin towards therapeutic intervention of CEES-induced skin injury. Second CounterACT-CRCE Research Symposium. Albuquerque, New Mexico, September 16-18, 2009.

265. Agarwal, R.: Efficacy and mechanism of colon cancer chemoprevention by silibinin,

at The 2009 China-US Forum on Frontiers of Cancer Research: Focus on Prevention, Changsha, China, October 2009.

266. Kevin T. Bauerle, Gagan Deep, Rebecca E. Schweppe, Agarwal, R. and Bryan R.

Haugen: Inhibition of Nuclear Factor-κB Signaling Attenuates Thyroid Cancer Cell Invasion and Decreases HUVEC Tubule Formation in an in vitro Model of Angiogenesis. Keystone Symposia: NFkB in Inflammation and Disease, 2009.

267. Agarwal, R.: Molecular mechanism of colon cancer chemoprevention by silibinin, at

the International Symposium on Cancer Chemoprevention and Translational Research, December 21st, 2009, JNU, New Delhi, India.

268. Agarwal, R.: Inflammation, Colon Cancer and Silibinin, at the 3rd International

Symposium on Translational Cancer Research, December 18th-21st, 2009, Bhubaneswar, India.

269. Inturi, Swetha; Tewari-Singh, Neera; White, Carl W. and Agarwal, R.: Oxidative

DNA damaging effects of sulfur mustard analog CEES on mouse skin cells. 49th Annual Meeting of Society of Toxicology, Salt lake City, Utah. March 7-11, 2010.

270. Jain, Anil K; Tewari-Singh, Neera; White, Carl W. and Agarwal, R.: Development of

efficient and applicable male SKH-1 hairless mouse skin toxicity model with sulfur mustard analog. 49th Annual Meeting of Society of Toxicology, Salt lake City, Utah. March 7-11, 2010.

271. Tewari-Singh, Neera; Jain, Anil K; Inturi, Swetha; White, Carl W. and Agarwal, R.:

Therapeutic efficacy of silibinin, a natural flavanone, in sulfur mustard analog induced skin toxicity. 49th Annual Meeting of Society of Toxicology, Salt lake City, Utah. March 7-11, 2010.

272. Kumaraguruparan Ramasamy, Lori D. Nield, Natalie J. Serkova, Kendra M.

Hasebroock, Alpna Tyagi, Komal Raina, Alvin M. Malkinson and Agarwal, R.: Silibinin selectively inhibits growth and progression of urethane-induced lung tumors in wild-type but not inducible nitric oxide synthase (/-) mice: potential usefulness of micro-computed tomography scanning in lung cancer chemoprevention studies. Presentation #948, AACR 101st Annual Meeting, Washington, DC, April 2010.

273. Komal Raina, Kameswaran Ravichandran, Subapriya Rajamanickam, Kendra M.

Hasebroock, Natalie J. Serkova and Agarwal, R.: Energy deprivation by Inositol


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Hexaphosphate inhibits prostate tumor growth and progression in TRAMP mice. Presentation #950, AACR 101st Annual Meeting, Washington, DC, April 2010.

274. Sangeeta Shrotriya, Chapla Agarwal and Agarwal, R.: Grape seed extract targets

TGFβ/Smad signaling in its potential efficacy against human head and neck cancer cells. Presentation #1876, AACR 101st Annual Meeting, Washington, DC, April 2010.

275. Komal Raina, Chapla Agarwal, Natalie J. Serkova and Agarwal, R.: Molecular

mechanism of cell death by silibinin in colorectal cancer: Apoptosis versus autophagy. Presentation #3790, AACR 101st Annual Meeting, Washington, DC, April 2010.

276. Samiha Mateen, Komal Raina, Chapla Agarwal and Agarwal, R.: Inhibition of

epigenetic chromatin-modification enzymes: histone deacetylases and DNA methyltransferases by silibinin in human NSCLC H1299 cells. Presentation #3796, AACR 101st Annual Meeting, Washington, DC, April 2010.

277. Aglaia Pappa, Agarwal, R., Nicholas H. Oberlies and David J. Kroll: Silibinin

depletes human prostate carcinoma cells of EZH2, reduces EZH2 phosphorylation, and enhances lysine 27 trimethylation of histone H3. Presentation #4875, AACR 101st Annual Meeting, Washington, DC, April 2010.

278. Manjinder Kaur, Shen-Chieh Chou, John A. Thompson, Agarwal, R. and Chapla

Agarwal: Influence of gallate esterification on the activity of procyanidin B2 in androgen-dependent human prostate carcinoma LNCaP cells. Presentation #5648, AACR 101st Annual Meeting, Washington, DC, April 2010.

279. Gagan Deep, Subhash Chander Gangar and Agarwal, R.: Silibinin inhibits epithelial

to mesenchymal transition in prostate cancer cells: Role of E-cadherin and beyond. Presentation #5650, AACR 101st Annual Meeting, Washington, DC, April 2010.

280. Subhash Chander Gangar, Gagan Deep and Agarwal, R.: Silibinin inhibits

advanced human prostate carcinoma-induced osteoclastogenesis. Presentation #5661, AACR 101st Annual Meeting, Washington, DC, April 2010.

281. Alpna Tyagi, Subhash Chander Gangar, Komal Raina, Agarwal, R. and Chapla

Agarwal: Grape seed extract induces apoptosis via reactive oxygen species-dependent mechanism in human non-small-cell lung cancer cells. Presentation #5687, AACR 101st Annual Meeting, Washington, DC, April 2010.

282. Chapla Agarwal, Komal Raina and Agarwal, R.: Anti-inflammatory effects of silibinin

in colorectal cancer: Targeting the activation of NF-κB signaling. Presentation #5692, AACR 101st Annual Meeting, Washington, DC, April 2010.

283. Molly M. Derry, Manjinder Kaur, Agarwal, R. and Chapla Agarwal: Grape seed

extract induces both intrinsic and extrinsic apoptotic pathways in its efficacy against


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human colorectal cancer cells harboring varying degrees of metastatic potential. Presentation #5721, AACR 101st Annual Meeting, Washington, DC, April 2010.

284. Bauerle KT, Deep G, Schweppe RE, Agarwal R and Haugen BR: NF kappa B-

dependent Growth in an Orthotopic Mouse Model of Advanced Thyroid Cancer Suggests a Role for Interleukin-8 and Angiogenesis. 92nd Annual Meeting of the Endocrine Society, June 2010.

285. Agarwal, R.: Develop CEES-induced skin toxicity models, and evaluate silibinin

efficacy” at 4th Annual NIH CounterACT Network Research Symposium, June 2010, San Francisco, CA.

286. Agarwal, R.: Silibinin efficacy in prostate cancer” at the International Cancer

Research Symposium, December 17-22, 2010, Trivandrum, India.

287. Agarwal, R.: Tumor microenvironment: promise and potential in chemoprevention research. International Conference on Frontiers in Carcinogenesis and Cancer Prevention: Scientific Advances and Public Health Initiatives, February 16-18, 2011.

288. Agarwal, R.: Inositol Hexaphosphate efficacy in prostate cancer. International Conference on Recent Advances in Cancer Research: Bench to Bedside, February 19-20, 2011.

289. Tewari-Singh, Neera; Jain, Anil K; Inturi, Swetha; Gu, Mallikarjuna; Agarwal,

Chapla; Day, Brian J.; White, Carl W and Agarwal, R. Therapeutic efficacy of catalytic antioxidant AEOL 10150 in attenuating sulfur mustard analog 2-chloroethyl ethyl sulfide induced skin injury. The 50th Annual Meeting of Society of Toxicology, Washington DC. March 6-10, 2011 (Talk); Abstract # 1756.

290. Jain, Anil K; Tewari-Singh, Neera; Inturi, Swetha; Gu, Mallikarjuna; White, Carl W

and Agarwal, R. Two-hit model of sulfur mustard analog skin injury involving DNA damage and induction of inflammatory mediators, in part via oxidative stress, in SKH-1 hairless mouse skin. 50th Annual Meeting of Society of Toxicology, Washington DC. March 6-10, 2011 (Poster); Abstract # 2040.

291. Kavitha C. Vijendra, Chapla Agarwal, Agarwal, R., Gagan Deep. Asiatic acid is an

effective alternative agent targeting growth, angiogenesis and invasiveness of malignant gliomas. Presentation # 3690, AACR 102nd Annual Meeting, Orlando, FL, April 2011.

292. Kavitha C. Vijendra, Gagan Deep, Gail Harrison, Michael Glode, Chapla Agarwal,

Agarwal, R. Oligonol, a novel lychee fruit-‐derived low-‐molecular weight procyanidin extract, inhibits angiogenesis: Implications for its use as angiopreventive agent against cancer. Presentation # 3695, AACR 102nd Annual Meeting, Orlando, FL, April 2011.


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293. Alpna Tyagi, Mallikarjuna GU, Barbara Fredrick, Chapla Agarwal, Sunitha Siriwardana, Agarwal, R., Robert A. Sclafani. Resveratrol induces DNA damage independent of Smad4 expression in its efficacy against human head and neck carcinoma cells. Presentation # 3708, AACR 102nd Annual Meeting, Orlando, FL, April 2011.

294. Samiha Mateen, Mallikarjuna Gu, Anil Jain, Chapla Agarwal, Daniel Chan, Agarwal,

R. Anti-‐tumorigenic effects of silibinin in combination with histone deacetylase inhibitors (TSA and SAHA): Involvement of G2/M arrest and apoptotic cell death. Presentation # 4592, AACR 102nd Annual Meeting, Orlando, FL, April 2011.

295. Molly M. Derry, Agarwal, R., Chapla Agarwal. Grape seed extract induces

apoptosis in human colorectal carcinoma through modulation of death receptors and anti-‐apoptotic molecules. Presentation # 4594, AACR 102nd Annual Meeting, Orlando, FL, April 2011.

296. Gagan Deep, Akash George, Chapla Agarwal, Agarwal, R. Silibinin targets

fibronectin-‐integrin interaction and actin remodeling towards inhibiting motility and proliferation of human prostate carcinoma PC3 cells. Presentation # 4598, AACR 102nd Annual Meeting, Orlando, FL, April 2011.

297. Agarwal, R.: Develop CEES-induced skin toxicity models, and evaluate silibinin

efficacy. 5th Annual NIH CounterACT Network Research Symposium, June 2011, Washington DC.

298. Tewari-Singh, Neera; Jain, Anil K; Inturi, Swetha; Day, Brian J.; White, Carl W and

Agarwal, R. Efficacy of AEOL 10150 and Silibinin in the treatment of sulfur mustard analog CEES-caused skin toxicity. The 5th Annual CounterACT Network Research Symposium, Washington, DC. June 21-23, 2011 (Poster).

299. Inturi, Swetha; Tewari-Singh, Neera; Agarwal, Chapla; White, Carl W and Agarwal,

R. Mechanisms of sulfur mustard analog 2-chloroethyl ethyl sulfide-induced DNA damage in skin epidermal cells and fibroblasts. Mountain West Society of Toxicology Meeting, Breckenridge, Colorado, September 8-9, 2011 (Poster).

300. Agarwal, R.: Inositol Hexaphosphate and Prostate Cancer: Efficacy and

Mechanism. 3rd China-US Forum on Frontiers of Cancer Research and 1st International Symposium on Stem Cell and Regenerative Medicine Conference, August 20-23, 2011, Zhengzhou, China.

301. Agarwal, R.: Targeting Tumor Microenvironment with Silibinin: Promise and

Potential for a Translational Cancer Chemopreventive Strategy. International Meeting on Natural Products and Cancer Targets: Progress and Promise, August 24-25, 2011, Zhengzhou, China.


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302. Agarwal, R.: Inositol Hexaphosphate and Prostate Cancer: Efficacy and Mechanism. Fourth International Symposium on Translational Cancer Research Cancer Prevention, December 16-19, 2011, Udaipur, India.

303. Agarwal, R.: Targeting tumor microenvironment with silibinin: promise and potential

for a translational prostate cancer chemopreventive strategy. International Symposium on Recent Advances in Cancer Research: Therapeutics to Chemoprevention, February 8-9, 2012, Central University of Gujarat, Ahmedabad, India.

304. Agarwal, R.: Targeting tumor microenvironment with silibinin: promise and potential

for a translational cancer chemopreventive strategy. 4th International Conference on Drug Discovery & Therapy, February 12-15, 2012, Dubaii, UAE.

305. Tewari-Singh, Neera; Jain, Anil K; Inturi, Swetha; Agarwal, Chapla; White, Carl W

and Agarwal, R. Therapeutic efficacy of silibinin in sulfur mustard analog induced skin injuries. The 51st Annual Meeting of Society of Toxicology, San Francisco CA, March 11-15, 2012 (Talk); Abstract #1803.

306. Jain, Anil K; Tewari-Singh, Neera; Inturi, Swetha; Gu, Mallikarjuna; Orlicky, David J.;

White, Carl W and Agarwal, R. Histopathological and inflammatory changes in nitrogen mustard-induced mouse skin injury and possible role of myeloperoxidase in neutrophil-mediated inflammation. The 51st Annual Meeting of Society of Toxicology, San Francisco CA, March 11-15, 2012 (Poster); Abstract #1345.

307. Agarwal, R.; Tewari-Singh, Neera; Jain, Anil K; Inturi, Swetha; Ammar, David; Agarwal, Chapla; Tyagi, Puneet; Kompella, Uday; Enzenauer, Robert W and Petrash, J Mark. Potential therapies for vesicant-inflicted ocular injuries. 51st Annual Meeting of Society of Toxicology, San Francisco CA, March 11-15, 2012. Abstract # 1346.

308. Inturi, Swetha; Tewari-Singh, Neera; Agarwal, Chapla; White, Carl W.; Agarwal, R. Mechanisms of sulfur mustard analogs, 2-chloroethyl ethyl sulfide and nitrogen mustard-induced DNA damage in skin cells. The 51st Annual Meeting of Society of Toxicology, San Francisco CA, March 11-15, 2012 (Talk); Abstract #1805.

309. Chapla Agarwal, Komal Raina, Alpna Tyagi, Sangeeta Shrotriya, Anal Patel, Agarwal, R. Grape seed extract targets bladder cancer cells via initiating both apoptotic and autophagic machineries. Presentation #598, AACR 103rd Annual Meeting, Chicago, IL, March 31-April 4, 2012.

310. Sreekanth C. Narayanapillai, Mallikarjuna Gu, Chapla Agarwal, Agarwal, R. Silibinin inhibits UVB-induced DNA-damage and apoptosis by enhancing interleukin-12 expression in JB6 cells and SKH-1 mouse skin. Presentation #1592, AACR 103rd Annual Meeting, Chicago, IL, March 31-April 4, 2012.


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311. Sangeeta Shrotriya, Gagan Deep, Mallikarjuna Gu, Manjinder Kaur, Anil K. Jain, Swetha Inturi, Agarwal, R., Chapla Agarwal. Grape seed extract induces irreparable DNA damage causing G2/M arrest and apoptosis selectively in head and neck squamous cell carcinoma cells: Potential involvement of reactive oxygen species. Presentation #1598, AACR 103rd Annual Meeting, Chicago, IL, March 31-April 4, 2012.

312. Samiha Mateen, Komal Raina, Chapla Agarwal, Daniel Chan, Agarwal, R. Silibinin synergizes with histone deacetylase (HDAC) inhibitors in upregulating E-cadherin expression in non-small lung cancer (NSCLC) cells. Presentation #1608, AACR 103rd Annual Meeting, Chicago, IL, March 31-April 4, 2012.

313. Manjinder Kaur, Mallikarjuna Gu, Chapla Agarwal, Michael Wempe, Agarwal, R. Bitter melon juice induces apoptotic death of human pancreatic carcinoma cells. Presentation #1612, AACR 103rd Annual Meeting, Chicago, IL, March 31-April 4, 2012.

314. Komal Raina, Sushil Kumar, Alpna Tyagi, Chapla Agarwal, Agarwal, R. Silibinin causes strong efficacy towards colon cancer stem cells by modulating IL-4 caused CD44 expression. Presentation #1637, AACR 103rd Annual Meeting, Chicago, IL, March 31-April 4, 2012.

315. Gagan Deep, Kavitha C. Vijendra, Anil K. Jain, Subhash C. Gangar, Chapla Agarwal, Agarwal, R. E-cadherin regulates ‘stemness’ and ‘bone metastasis’ of prostate cancer cells. Presentation #3426, AACR 103rd Annual Meeting, Chicago, IL, March 31-April 4, 2012.

316. Komal Raina, Kameswaran Ravichandran, Anil Jain, Mallikarjuna Gu, Yogesh Sharma, Ritambhara Wadhwa, Agarwal, R. Stage specific inhibitory effect and associated mechanisms of insositol hexaphosphate on tumor progression and angiogenesis in TRAMP model. Presentation #5421, AACR 103rd Annual Meeting, Chicago, IL, March 31-April 4, 2012.

317. Sushil Kumar, Komal Raina, Chapla Agarwal, Agarwal, R.: Effect of silibinin on the growth kinetics of 3D tumor spheroids: Colorectal cancer cells enriched for cancer stem cell phenotype. Presentation #LB-179, AACR 103rd Annual Meeting, Chicago, IL, March 31-April 4, 2012.

318. Agarwal, R.: Tumor microenvironment as a novel druggable target by silibinin: promise and potential for a translational cancer chemopreventive strategy. 2012 CRI Cancer Symposium: Innovative Approaches to Explore Novel Druggable Targets, May 16-19, 2012, Seoul National University, Seoul, S. Korea.

319. Tewari-Singh, Neera; Jain, Anil K; Inturi, Swetha; Orlicky, David J; White, Carl W

and Agarwal, R. Biomarkers of nitrogen mustard-induced skin injuries in SKH-1


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hairless and C57BL/6 mice. 6th Annual CounterACT Network Research Symposium, San Francisco CA, June 26-28, 2012.

320. Agarwal, R. Evaluation of novel therapies for vesicant skin toxicities (U54 ES015678) Year 6 CounterACT project progress presentation at the 6th Annual CounterACT Network Research Symposium, San Francisco CA, June 26-28, 2012.

321. Tewari-Singh, Neera; Jain, Anil K; Inturi, Swetha; Ammar, David; Agarwal, Chapla; Tyagi, Puneet; Kompella, Uday; Enzenauer, Robert W; Petrash, J Mark and Agarwal, R. Potential therapies for vesicant-inflicted ocular injuries. 5th Military Vision Symposium on Ocular & Vision Injury, September 18-20, 2012, Boston, MA.

322. Agarwal, R.: Frequently consumed dietary supplement milk thistle extract: from anti-hepatotoxicity to anti-prostate cancer efficacy in humans. 9th International Conference of the Society for Integrative Oncology, October 8-10, 2012, Albuquerque, NM.

323. Agarwal, R.: Targeting Molecular Pathways in the Tumor Microenvironment: A holistic Approach for Cancer Chemoprevention. Presentation #CN08-03, 11th Annual AACR international Conference on Frontiers in Cancer Prevention Research, October 16-19, 2012, Anaheim, CA.

324. Molly Derry, Komal Raina, Velmurugan Balaiya, Anil Jain, Sangeeta Shrotriya, Agarwal, R. and Chapla Agarwal. Chemopreventive potential of Grape Seed Extract in azoxymethane-induced colon tumorigenesis in the A/J mouse model: interlinking miRNA expression and inflammatory and cytokine signaling. Presentation #A32, 11th Annual AACR international Conference on Frontiers in Cancer Prevention Research, October 16-19, 2012, Anaheim, CA.

325. Cynthia Tilley, Srirupa Roy, Gagan Deep, Chapla Agarwal, Agarwal, R.: Silibinin Exerts Its Protective Effects Against UVB-Induced Photodamage and Skin Carcinogenesis Through p53. Presentation #A85, 11th Annual AACR international Conference on Frontiers in Cancer Prevention Research, October 16-19, 2012, Anaheim, CA.

326. Harold J Ting, Gagan Deep, Chapla Agarwal, Scott D. Cramer, Lina M. Romero, Agarwal, R.: Silibinin inhibits prostate cancer and stromal cells interaction through targeting TGFβ and α-smooth muscle actin. Presentation #A86, 11th Annual AACR international Conference on Frontiers in Cancer Prevention Research, October 16-19, 2012, Anaheim, CA.

327. Agarwal, R.: Silibinin ‘the double edgd sword’ targeting both the initiators and the initiated ones in colon cancer. 3rd International Cancer Research Symposium: Defining & Translating Science for Disease Prevention and Therapy, December 18-21, 2012, Kolkata, India.


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328. Gagan Deep, Anil K Jain, Samiha Mateen, Kavitha C Vijendra, Subhash C Gangar, Chapla Agarwal, Agarwal, R.: Src-β catenin-SNAI1 axis is critical for the stemness and bone metastasis of E-cadherin lacking prostate cancer cells. Presentation #C73, An AACR Special Conference on Tumor Invasion and Metastasis, January 20-23, 2013, San Diego, CA.

329. Tewari-Singh, Neera; Jain, Anil K; Inturi, Swetha; Orlicky, David J; White, Carl W and , Agarwal, R.: Progression of injury and toxic effects following nitrogen mustard exposure in SKH-1 hairless and C57BL/6J mice skin: clinical and pathological significance. 52nd Annual Meeting of the Society of Toxicology at San Antonio, TX March 10-14, 2013. Abstract #366.

330. Jain, Anil K; Tewari-Singh, Neera; Inturi, Swetha; Orlicky, David J; White, Carl W and Agarwal, R.: A comparative study on biomarkers of nitrogen mustard-induced skin injury in male SKH-1 hairless and C57BL/6J mice. 52nd Annual Meeting of the Society of Toxicology at San Antonio, TX March 10-14, 2013. Abstract #369.

331. Inturi, Swetha; Tewari-Singh, Neera; Agarwal, Chapla; White, Carl W and Agarwal, R.: Activation of DNA damage repair pathways in response to nitrogen mustard-induced DNA damage and toxicity in skin keratinocytes. 52nd Annual Meeting of the Society of Toxicology at San Antonio, TX March 10-14, 2013. Abstract #365.

332. Kumar, Dileep; Tewari-Singh, Neera; Inturi, Swetha; Agarwal, Chapla; Jain, Anil K; Dhar, Deepanshi; White, Carl W and Agarwal, R.: Mechanisms of vesicating agent nitrogen mustard-induced skin injury in SKH-1 hairless mice. 52nd Annual Meeting of the Society of Toxicology at San Antonio, TX March 10-14, 2013. Abstract #371.

333. Anil K. Jain, Komal Raina, Agarwal, R. Deletion of p21/Cdkn1a confers protective effect against prostate tumorigenesis in Transgenic Adenocarcinoma of the Mouse Prostate model. Presentation #306, AACR 104th Annual Meeting, Washington D.C., April 7-10, 2013.

334. Kumaraguruparan Ramasamy, Gagan Deep, Alpna Tyagi, Chapla Agarwal, Agarwal, R. Silibinin inhibits tumor associated macrophages-induced lung cancer cell growth and invasiveness by down- regulating macrophage migration inhibitory factor. Presentation #2579, AACR 104th Annual Meeting, Washington D.C., April 7-10, 2013.

335. Gagan Deep, Anand Ramteke, Amandla Atilano-Roque, Chapla Agarwal, Agarwal, R. Silibinin targets stemness and aberrant metabolic signaling in prostate cancer cells. Presentation #2587, AACR 104th Annual Meeting, Washington D.C., April 7-10, 2013.

336. Alpna Tyagi, Komal Raina, Sushil Kumar, Agarwal, R., Chapla Agarwal. Procyanidin B2 3,3″-di-O gallate causes strong efficacy towards prostate cancer stem cells via targeting Notch1 signaling. Presentation #2593, AACR 104th Annual Meeting,


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Washington D.C., April 7-10, 2013.

337. Cynthia Tilley, Gagan Deep, Chapla Agarwal, Agarwal, R. Silibinin induces cell cycle arrest and apoptotic death via targeting hedgehog signaling in basal cell carcinoma cells. Presentation #3664, AACR 104th Annual Meeting, Washington D.C., April 7-10, 2013.

338. Sushil Kumar, Komal Raina, Chapla Agarwal, Agarwal, R. Silibinin strongly modulates the cytokine interleukin-4/6 survival signals in colon cancer stem cells. Presentation #4877, AACR 104th Annual Meeting, Washington D.C., April 7-10, 2013.

339. Agarwal, R., Komal Raina, Chapla Agarwal. Energy deprivation by silibinin in colorectal cancer cells: a double-edged sword targeting both apoptotic and autophagic machineries through mitochondrial involvement. Presentation #40, Cell Cymposium, Mitochondria: from Signaling to Disease, Lisbon, Portugal, May 5-7, 2013.

340. Agarwal, R. Strategies to control prostate cancer by chemoprevention approaches. 3rd International Conference of the International Association of Medical and Biological Researchers: Cancer – Present and Future Perspective, September 16-18, 2013, Mauritius.

341. Agarwal, R. Silibinin and prostate cancer prevention. 6th International Conference

on Polyphenols and Health, October 16-19, 2013, Buenos Aires, Argentina.

342. Agarwal, R. Silibinin efficacy in non-melanoma skin cancer. International Symposium on Frontiers in Cancer Research: Prevention to Therapeutics, November 15-16, 2013, Amity University, Noida, India.

343. Agarwal, R. Colon cancer chemoprevention by silibinin in the new era: targeting the

initiators and the initiated ones, a cancer stem cell perspective. International Conference on “Recent Advances in Cancer Prevention and Therapeutics” at the School of Life Sciences, CUG, November 19-20, 2013, Gandhinagar, India.

Rajesh Agarwal, Ph.D. - Denver, Colorado · 2014-07-07 · Rajesh Agarwal, Ph.D. 10 and skin...

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