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Curriculum Vitae

Name: Dr. Rajesh G. Kalkhambkar M.Sc.,Ph.D & PDF (USA)

Address: Office: Asst Professor, Department of Chemistry

Karnatak University’s Karnatak Science College, Dharwad Karnataka 580001, INDIA

Phone: +91-836-2215403 Fax: +91-836-2744334 Cell: +91-990-2831760

E-mail: rgkalkhambkar@gmail.com rgkalkhambkar@kscd.ac.in

Webpage: http://www.kcd.org.in

Date of Birth: December 31st, 1979

Academic Qualifications:

B.Sc (Chemistry, Physics and Mathematics), Karnatak University, Dharwad, Karnatak 1999-2001.

M.Sc (Organic Chemistry), Karnatak University, Dharwad, Karnatak 2001-2003.

Ph.D (Synthetic Organic Chemistry), Karnatak University, Dharwad, Karnatak 2003-2007

(Awarded in 2008)

Title of Ph.D Thesis: “Synthetic Studies in Heterocycles of Biological Interest” Name of Research Supervisor- Late... Dr (Smt.) G. M. Kulkarni (Associate Professor of Chemistry, Department of Chemistry, Karnatak Science College, Dharwad)

Positions Held: 1. R & D Manager in the Department of Research and Development. BenzoChem Industries Pvt.

Ltd. Mumbai, Maharastra. (September 2007-September 2008)

2. Postdoctoral Research Fellow in the Department of Medicinal Chemistry at AstraZeneca India

Pvt Ltd. Bangalore, Karnatak. (September 2008-March 2010)

3. Postdoctoral Research Fellow in the Department of Chemistry, University of North Florida,

Jacksonville, Florida USA, in the synthetic laboratory of Professor, Kenneth K. Laali. (April 2010-

June 2011)

4. Assistant Professor, Department of Chemistry Karnatak Science College, Dharwad (2011-Till the Date)

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Awards & Honors:

1. Hon, Shri Sharadraoji Pawar Gold Medal for standing first to B.Sc in the

B.K.College, Belgaum In the year 2001.

2. National Merit Scholarship at B.Sc (1999-2001)

3. National Merit Scholarship at M.Sc (2001-2003)

4. University Research Felloship at Ph.D (2003-2007)

5. Dr. D. S. Bhakuni Young Scientist Award at the 43rd annual Convention

Of Chemists organized by the Indian Chemical Society, Kolkata at Dr. Babasaheb

Ambedkar Marathawada University, Aurangabad in the year December 2006.

6. Dr. D. S. Bhakuni Young Scientist Award at the 50th annual Convention

Of Chemists organized by the Indian Chemical Society, Kolkata at Punjab university,

Chandigarh, Punjab in the year December 2013.

7. Honored with for Best Research Publication Award by Vision Group on Science & Technology

Govt. Of Karnataka Bangalore, for the year 2016-17 in October 2017.

National/International Committee Work:

1. Member, International Year of Chemistry, 2011 at Karnatak Science College, Dharwad (December 2011) 2. Member, National conference in Present Sinareo of Chemical Sciences and its Technological

Perspectives at Department of chemistry Karnatak Science College, Dharwad in October 2014

Research Interest:

Broad area of interest in Synthetic Organic and Medicinal Chemistry

Synthetic work involves one-pot and multi-step synthesis of novel coumarin and 1-aza coumarin molecules of biological importance. Synthetic work also involves synthesis and characterization of small organic Molecules and drug intermediates. Synthesis involves the use and handling air and moisture sensitive Reagents, solvents, and organic compounds in general and extensive use of ionic Liquid as a catalyst and as a solvent medium, a tool for green chemistry in particular. Characterization of all the newly synthesized molecules involves the use of IR,

1H NMR, 13C NMR, 19F NMR, 2D-NMR, GC-MS, FAB-MS, LC-MS, ESI-MS and some of the molecules are characterized by X-Ray Diffraction study.

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Biological evaluation (in collaboration with microbiology department) involves the in vitro antibacterial and antifungal activities with minimum four to five bacterial and fungal strains.

Pharmacological evaluation (in collaboration with institutes of pharmacy) involves Invivo analgesic and anti-inflammatory activities.

Teaching Interest:

Thorough in teaching theory and practicals for Pre-University (PUC), Under Graduate (B.Sc) and

Post graduate classes (M.Sc).

Topics of my interest in organic chemistry.

Introduction to Modern Organic Chemistry

Organic Name Reactions

Heterocyclic Chemistry

Reagents in Organic Synthesis

Spectroscopy in Organic Synthesis

Stereochemistry

Plants products viz Alkaloides and Terpenoids

Post-graduate (M. Sc) Students trained in synthetic organic research (Projects)

1. Kum. Trishaladevi A. Durgannavar (2010-2012), scored highest marks 133/150 for the

project entitled “Synthesis of Nitriles by dehydration of aldoximes” at Karnatak Science

College Dharwad (2012). Presently pursuing the Ph.D in Dongukk university, Seoul, South

Korea

2. Mr. Shrishail Pattanshetty (2012).

3. Mr. Kirthi Naik (2013).

4. Mr. Sunil Vagadole (2013)

5. Mr. Pravinkumar B. Bilkar (2014)

6. Mr. Rohit Matade (2014)

7. Mr. Nitesh Naik (2015)

8. Mr. Mohamad Arif I. Madaki (2015)

Presently 3 students are working for M.Sc Dissertation and 1 working for Ph.D

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Post-graduate (M. Sc) Students working for projects / Ph.D 1. Mr. Hemantkumar M. Savanur is working as Project Fellow in SERB-DST Fast track

Project No. SB/FT/CS-175/2013 dated 12/09/2014 funded by SERB-DST New Delhi since

Feb 2015.

2. Mr. Pavan Prabhala working for Ph.D since December 2017

Membership (Research / Academic): 1. Life member of The Indian Science Congress Association, Kolkata Memb No. L27126 2. Research collaboration with Universities and Institutes of USA, UK and South Korea.

Funding Agencies / Sponsored Research (National and International): 1. DST has sponsored one major research project worth 25.2 Lakhs entitled “Synthesis and

structural modification of coumarin and quinolinone linked azole derivatives as novel ‘drug like’ molecules” DST-Fast track project for young scientist in November 2014.

2. UGC-has sponsored Minor research project entitled “Synthesis of some novel room

temperature ILs as duel solvents / reagents in organic synthesis” worth Rs. 4.9 Lakhs

for the year 2015-16

3. Applied for EMR-SERB project worth 45 Lakhs for the year 2018-19

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List of Research Publications TOTAL LIST OF 40 RESEARCH PAPERS ( 38 PUBLISHED AND 2 Communicated)

Complete list of publications in SCI Journals & other Referred Journals

a) Total 789 citations (incomplete) / 36 papers b) G-Index = 13, H index = 16

40. Click chemistry inspired design and synthesis of coumarin and quinolinone linked 1,2,3-triazoles as promising anti-microbial agents. Hemant M. Savanur. Saileja M. Ganapathi, Krishana N. Nayak and Rajesh Kalkhambkar Chem Select. 2018, (In Press for publication) IF: 4.12

39. Piperidine-appended imidazolium Ils as task-specific basic IL for Suzuki and heck reactions and Horner-Emmons-Heck protocols Hemant M. Savanur, Rajesh G. Kalkhambkar and Kenneth K. Laali Applied Catalysis A, General. 2017, 543, 150–161. IF. 4.56

38. [bmim(SO3H)][OTf]/[bmim][X] and Zn(NTf2)2/[bmim][X] (X = PF6 and BF4); efficient catalytic systems for the synthesis of tetrahydropyrimidin-ones (-thiones) via the Biginelli reaction Hemant M. Savanur, Rajesh G. Kalkhambkar, Gopalakrishnan Aridoss and Kenneth K. Laali Tetrahedron. Letters. 2016, 57, 3029-3035. IF: 2.79

37. Pd(OAc)2 catalyzed homocoupling of arenediazonium salts in imidazolium Iionic liquids : Synthesis of Symmetrical biaryls Hemant M. Savanur, Rajesh G. Kalkhambkar and Kenneth K. Laali Tetrahedron. Letters. 2015, 57, 663-667. IF: 2.84

36. Highly efficient synthesis of amides from ketoximes using triflic anhydride

Rajesh Kalkhambkar and Hemant M. Savanur.

RSC Advances. 2015, 5, 60106-60113 IF: 3.84

35. Structure Guided Lead Generation for M. tuberculosis Thymidylate Kinase (Mtb TMK): Discovery of 3‑ Cyanopyridone and 1,6-Naphthyridin-2-one as Potent Inhibitors Maruti Naik, A Balachandra S. Bandodkar, Begur V. Varun,† Shantika Bhat, Rajesh Kalkhambkar, Manoranjan Panda J. Med. Chem. 2015, 58, 753−766 IF: 5.96

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34. Triflic Anhydride: A Mild Reagent for Highly Efficient Synthesis of 1,2-Benzisoxazoles, Isoxazolo, and Isothiazolo Quinolines Without Additive

or Base Rajesh G. Kalkhambkar, G Aridoss, Yeon Tae Jeong. Synth Commun. 2014, 44, 547-555 IF: 1.06

33. Highly Efficient Synthesis of 1,3-Dioxanes via Prins reaction in Brønsted-acidic imidazolium Ionic Liquid Rajesh G. Kalkhambkar, G Aridoss, Yeon Tae Jeong. Synth Commun. 2014, 44, 762-771 IF: 1.06

32. Synthesis, Characterization and antimicrobial studies of benzdipyran analogue of

Chloramphenicol. Rajesh G. Kalkhambkar, Geeta M. Kulkarni, J.C.Kadakol, Y.T.Jeong, M.V.Kulkarni J.Het.Chem. 2013, 50, 5, 1108-1115 IF: 1.22

31. A facile One Pot Synthesis of new tricyclic Coumarins from Single Synthon. Rajesh G. Kalkhambkar, Geeta M. Kulkarni and Manohar V. Kulkarni. J.Het.Chem. 2013, 50, 5, 1014-1020 IF: 1.22

30. Brønsted-acidic imidazolium ionic liquid [bmim(SO3H)][OTf]-A mild catalyst for highly Efficient synthesis of coumarins Yuvaraj Haldorai, Rajesh G. Kalkhambkar and Jae-Jin Shim

Asian. J. Chem. 2013, 25, 16, 9379-9383 IF: 0.33

29. Pd(OAc)2 catalyzed synthesis of 2-aryl- and 2-heteroaryl-benzoxazoles and benzothiazoles in imidazolium ionic liquids (ILs) without additives and with recycling/reuse of the Ionic Liquid. Rajesh G. Kalkhambkar, Kenneth K Laali. Tetrahedron. Letters. 2012, 53, 4212-4215. IF: 2.68

28. Synthesis and Biological evaluation of Cyclic imides with coumarins and azacoumarins Marulasiddaiah. R, Rajesh G. Kalkhambkar and Manohar V. Kulkarni. Open. J. Med. Chem. 2012, 2, 89-97. IF: 0.58

27. Pd(OAc)2-catalyzed cross-coupling of polyfluoroarenes with simple aromatics in imidazolium ionic liquids (ILs) without oxidant and additive and with recycling/reuse of the Ionic Liquid. Rajesh G. Kalkhambkar, Kenneth K Laali. Tetrahedron. Letters. 2011, 52, 5525-5529. IF: 2.68

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26. Reaction of trifyl-imidazole with aldoximes: facile synthesis of nitriles and formation of novel aldoxime-bis(N-trifyl)-imidazole adducts Rajesh G. Kalkhambkar, Scott D. Bunge, Kenneth K. Laali . Tetrahedron. Letters. 2011, 52, 5184-5187. IF: 2.68

25. Arenediazonium Salts Immobilized in Imidazolium Ionic Liquids as Electrophilic

Partners in the Pd(OAc)2 - Catalyzed Matsuda-Heck Arylation. Rajesh G. Kalkhambkar, Kenneth K Laali.

Tetrahedron. Letters. 2011, 52, 1733-1737. IF: 2.68

24. Highly Efficient Synthesis of Amides via Ritter reaction in Ionic Liquids. Rajesh G. Kalkhambkar, Saraha N. Waters, Kenneth K Laali.

Tetrahedron. Letters. 2011, 52, 867-871. IF: 2.68

23. Synthesis and biological activities of novel ethers of quinolinone linked with Coumarins. Rajesh G. Kalkhambkar, Geeta M. Kulkarni, Chandrappa M. Kamanvalli. G. Aridoss. Monatshefte fur Chemie - Chemical Monthly. 2011, 142, 305-315. IF: 1.62

22. Synthesis and Biological studies of some new acrylic acid ethyl esters of quinolinone. Rajesh G. Kalkhambkar, Geeta M. Kulkarni, G. Aridoss, J C. Kadakol, Y.T. Jeong. Monatshefte fur Chemie - Chemical Monthly. 2012, 143, 1075. IF: 1.62

21. 1-(3,5-Dichlorophenyl)-1H-1,2,3,4-tetrazole

Rajesh G. Kalkhambkar, D. Gayathri, Vivek K. Gupta, Rajni Kant and Yeon Tae Jeong Acta Cryst. 2012, E68, o433. IF: 0.42

20. (E)-Ethyl 2-cyano-3-(furan-2-yl)acrylate Rajesh G. Kalkhambkar, D. Gayathri, Vivek K. Gupta, Rajni Kant and Yeon Tae Jeong Acta Cryst. 2012, E68, o1482. IF: 0.42

19. 8-Formyl-4-methyl-2-oxo-2H-chromen-7-yl4-methylbenzenesulfonate

H. Yuvaraj, D. Gayathri, Rajesh G. Kalkhambkar, Geeta M. Kulkarni and Rajendra M. Bapset Acta Cryst. 2011, E67, o1513. IF: 0.37

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18. 8-[(Hydrazinylidene)methyl]-4-methyl-2-oxo-2H-chromen-7-yl-4- Methylbenzenesulfonate.

Haldorai Yuvaraj, S. Sundaramoorthy, D. Velmurugan and Rajesh G. Kalkhambkar Acta Cryst. 2011, E67, o323. IF: 0.37

17. (Z)-2-[2-(4-Methylbenzylidene)hydrazinyl]pyridine.

Haldorai Yuvaraj, S. Sundaramoorthy, D. Velmurugan and Rajesh G. Kalkhambkar Acta Cryst. 2011, E67, o178. IF: 0.37

16. (E)-Ethyl 2-cyano-3-(1H-pyrrol-2-yl)acrylate

Haldorai Yuvaraj, D. Gayathri, Rajesh G. Kalkhambkar, Vivek K. Gupta and Rajnikant Acta Cryst. 2011, E67, o2165. IF: 0.37

15. (Z)-2-[2-(4-Methylbenzylidene)hydrazinyl]pyridine. Haldorai Yuvaraj, S. Sundaramoorthy, D. Velmurugan and Rajesh G. Kalkhambkar Acta Cryst. 2011, E67, o178. IF: 0.37

14. (Z)-2-[2-(4-Methylbenzylidene)hydrazinyl]pyridine. Haldorai Yuvaraj, S. Sundaramoorthy, D. Velmurugan and Rajesh G. Kalkhambkar Acta Cryst. 2011, E67, o178. IF: 0.37

13. 1-(2-Azidoacetyl)-3-methyl-2,6-diphenylpiperidin-4-one. Haldorai Yuvaraj, S. Sundaramoorthy, D. Velmurugan and Rajesh G. Kalkhambkar Acta Cryst. 2010, E66, o2733. IF: 0.42

12. Ethyl 4-(3-bromophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-

carboxylate. Haldorai Yuvaraj, S. Sundaramoorthy, D. Velmurugan and Rajesh G. Kalkhambkar Acta Cryst. 2010, E66, o3325. IF: 0.42

11. Synthesis and Biological studies on Mono and Bis-methylene bridged heterocyclic Sulfides and sulfones carbostyrils. Rajesh G. Kalkhambkar, Geeta M. Kulkarni, R. Nagendra Rao and H. Shivakumar

J.Sulphur.Chemistry. 2009, 30, 6, 596-610. IF: 1.12

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10. Solid State Confirmation of [2-Chloro-quinolin-3-ylmethylene]-phenyl-amine. Rajesh G. Kalkhambkar, Geeta M. Kulkarni, H.S.Hwang and C. S. Lee

Acta Cryst. 2008, E64, O258. IF: 0.41

09. Synthesis and Biological evaluation of some new fluorinated Coumarins and 1-aza coumarins. Rajesh G. Kalkhambkar, Geeta M. Kulkarni, N.Premkumar, and Chang M. Sun Eur.J.Med.Chem. 2008, 43, 2178-2188. IF: 3.43

08. The inhibition effects of chloroquinolines on the corrosion of mild steel in HCl.

A.V.Shanbhag, T.V.Venkatesha, R.A.Prabhu, R. G. Kalkhambkar and G.M.Kulkarni

Materials Chemistry and Physics. 2008, 108, 283-289. IF: 2.42

07. Inhibition effects of some Schiff’s bases on the corrosion of mild steel in HCl Solution.

R.A. Prabhu, T.V. Venkatesha b, R. G. Kalkhambkar and G.M. Kulkarni, Corrosion Science. 2008, 50, 3356–3362. IF: 4.32

06. Corrosion inhibition of mild steel in acidic medium using hydrazide derivatives. A.V.Shanbhag, T.V.Venkatesha, R.A.Prabhu, R. G. Kalkhambkar and G.M.Kulkarni J. Appl. Electrochem. 2008, 38, 279-287. IF: 2.14

05. A facile Selective and highly efficient method of acylation of amines. M.B.Patil, M.V.Kulkarni, R. G. Kalkhambkar and G.M.Kulkarni

Synthetic.Communication. 2008, 38, 2929-2940. IF: 1.06

04. Crystal Structure of 7-Methyl-4-[(4-fluoro) anilinomethyl] coumarin. Rajesh G. Kalkhambkar, Geeta M. Kulkarni and C. S. Lee

Analytical Sciences, Japan. 2007, 23, x31 - x32. IF: 0.32

03. Synthesis and Pharmacological activities of some new Triheterocyclic Thiazoles. Rajesh G. Kalkhambkar, Geeta M. Kulkarni, R. Nagendra Rao and H. Shivakumar

Eur.J.Med.Chem. 2007, 42, 1272-1276. IF: 3.43

02. Crystal Structure of 4-[(4-formyl) phenoxymethyl] carbostyril. Rajesh G. Kalkhambkar, Geeta M. Kulkarni, H.S.Hwang and C. S. Lee Analytical Sciences, Japan. 2007, 23, x145 – x146. IF: 0.32

01. Inhibition effect of some imines on the corrosion of mild steel in HCl

A.V.Shanbhag, R.A.Prabhu, G.M.Kulkarni, R. G. Kalkhambkar and T.V.Venkatesha Ind.J.Chem.Technol. 2007, 14, 584-591. IF: 0.58

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Research papers submitted to Journals for publication

42. Synthesis of Diverse Libraries of C-5 Substituted Imidazole and Oxazole

Derivatives via One-pot Sequential Van Leusen-Suzuki, Van Leusen-Heck and Van

Leusen-Sonogashira Protocols in Imidazolium ILs as Solvent and Base

H. M. Savanur, R. G. Kalkhambkar, K. K. Laali

Eur.J.Org.Chem (2018) IF: 4.94

41. Synthesis and molecular docking studies of coumarin and quinolinone linked

miconazole analogues and their anti-fungal activities. Hemant M. Savanur. Geeta M. Pawashe, Shriniwas S Reddy and Rajesh Kalkhambkar Bio.Org.Med.Chem. 2017 IF: 2.98

National / International Conferences / Seminars attended

National / International Conferences / Seminars attended

13. Oral presentation of research paper entitled “Pd(OAc)2 catalysed homocoupling of arene diazonium satls in ionic liquids : Synthesis of Symmetrical biaryls at RSC-International work shop in Chemistry for tommorows world at Delhi University New Delhi in December 2015.

12. Oral presentation of research paper entitled “highly efficient synthesis of amides

from ketoximes using Trifluoromethanesulfonic anhydride” at UGC New Delhi

sponsored, National conference in Present Sinareo of Chemical Sciences and its

Technological Perspectives at Department of chemistry Karnatak Science

College, Dharwad in October 2014.

11. Oral presentation of research paper entitled “Trifluoromethanesulfonic

Anhydride a mild and efficient reagent for highly efficient synthesis of nitriles

from aldoximes and amides from ketoximes” at 50th

annual convention of

chemists organized by Indian chemical society Kolkata at Punjab university

Chandigarh in December 2013.

10. Poster presentation on Highly Efficient Synthesis of 1,3-Dioxanes via Prins

reaction in Brønsted-acidic imidazolium Ionic Liquid at international conference

in "Chemical Constellation Cheminar - 2012 (CCC-2012)" at Department of

Chemistry, National Institute of Technology, Jalandhar, Punjab INDIA on 10-12th

September 2012.

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09. Poster presentation on Reaction of Trifyl-imidazole with Aldoximes: Facile

Synthesis of Nitriles and formation of novel Aldoxime/(bis)N-trifyl imidazole

adduct by K. K. Laali in “43rd

IUPAC World Chemistry Congress-Bridging

Innovation Among the Americas and the World” at San Juan, Puerto Rico, USA.

on 30 July 2011 to 07 August 2011.

08. Attended the one day Training / Seminar in “Fire Prevention and Fire Fighting”

Organized by „WHEN-IT-STRIKES‟ Crisis management Pvt.Ltd at AstraZeneca

India Pvt.Ltd, Bangalore in The year 2009.

07. Attended the “45th

Annual Convention of Chemists” Organized by the Indian

Chemical Society, Kolkata at Krnatak University, Dharwad, Karnataka in the

year 2009.

06. Attended the one day Symposium on “Recent Trends in NMR and Users

Meeting” Organized By the NMR Research Centre, Indian Institute of Science,

Bangalore in the Year 2007.

05. Attended the “43rd

Annual Convention of Chemists” Organized by the Indian

Chemical Society, Kolkata at Dr. Babasaheb Ambedkar Marathawada

University, Aurangabad in the year 2006.

04. Attended the 7th

Tetrahedron Symposium on “Recent Challenges in Organic

Chemistry” At Kyoto, Japan in the year 2006.

03. Participated in the “Intellectual Property Rights Awareness Programme”

Organized by CIPRA, National Law School of India University, Bangalore and

PG Department of Law, Karnatak University, Dharwad in the year January 2005.

02. Attended the One-day seminar on “Nuclear Energy – 50 years in the service of

Nation” Organized By the Nuclear Power Corporation of India Ltd and Karnatak

University, Dharwad in the year April 2004.

01. Participated in the “Professor S. Ramasheshan Distinguished Lecture” Organized

by AstraZeneca Research Foundation, Bangalore in the year 2004.