1

Effective June 2015

Laboratory Services Catalog

Providing You with Personalized Clinical Assessments

View the current catalog electronically at www.neuroscienceinc.com/labcatalog

1 21

As we enter our 20th year in business, we reflect on our beginnings as a provider of innovative laboratory

testing by Pharmasan Labs in 1996, to the launch of our partner company, NeuroScience, Inc., in 2000 that

introduced unique formulations designed to address imbalances revealed through laboratory testing. This

marked the birth of our Assess and Address™ model for personalized patient care, which still thrives today.

New and Exciting Direction

We recognize the evolving need for change in patient care and patients' expectations from their healthcare

practitioners. More than ever, patients are taking control of their health and demanding care that allows them to

get better faster and enjoy the healthy lifestyle they deserve.

Pharmasan Labs, along with their partner NeuroScience, Inc., has taken the lead in focusing on a model that

identifies the root cause of symptoms and produces improved, long-term outcomes.

Never satisfied with the status quo, we have further evolved to provide you with unparalleled support toward

this end.

A Provider of Personalized, Clinical Solutions…this is WHO WE ARE.

Pharmasan Labs is committed to providing you the useful clinical assessments and tools you need to thrive in

this rapidly changing healthcare market to better serve your patients and grow your practice.

Ushering in a New Age of Personalized Care

Dr. Gottfried Kellermann and Mieke Kellermann

Getting Started ......................................4

Sleep 360o .................................................5

Fatigue 360o .............................................6

Mood 360o .................................................6

Cardio 360o ...............................................7

Category Descriptions .........................8

Neurotransmitters ..................................9

Neurotransmitters & Endocrine .....10

Endocrine ................................................. 11

NeuroCardio ........................................... 12

Genetics.............................................. 13-14

Inflammation/Oxidative Stress ..15-16

Immune ................................................17-19

General Health ......................................20

Quick Reference ............................ 21-24

Biomarker Specific Index ................ 25

Ordering/Contact Information ...... 26

Order Form ............................................ 28

Table of Contents

The Neuro-Endo-Immune (NEI) Brain-Body Connection

Neuroendoimmunology is an emerging field of medical science that seeks to

understand the interconnectedness of the nervous, endocrine, and immune

systems. Progressive research in this field suggests each of these three

systems function as a larger whole, termed the “NEI SuperSystem™.” Within

this supersystem, the nervous system plays the integral role of modulating the

function of the immune and endocrine systems via the hypothalamic-pituitary

axis and innervation of endocrine and immunological organs.

The Nervous System Runs the Show

The nervous system, comprised of the brain, the spinal cord, and nerve tissues

distributed throughout the body, is considered one of the most complex

systems in existence. In higher functioning organisms, the

nervous system performs complex processes including

thought, memory, and emotions. Serving primarily as a

“master control center,” the nervous system regulates

the function of all other bodily systems. 

However, due to the interconnected nature of this

larger system, the nervous system is also reciprocally

influenced by the effects of the endocrine and immune

systems. Disruptions in the function of one system will

ultimately have an impact on the function of all three

systems. 

Optimal health is only possible when the

nervous, endocrine, and immune systems are

in balance. Imbalances in these systems occur

as a result of exposure to psychological or

physical challenges. Underlying stressors such

as mental stress, poor diet, unhealthy lifestyles,

infections, organ diseases, environmental toxins,

and/or general immune system activation will

alter the NEI SuperSystem™ and lead to

patient symptoms and conditions. Utilizing

an assess and address approach allows

you to rapidly identify NEI system

imbalances and develop treatment

plans to restore balance and

relieve patient symptoms.

Our Expertise - The NEI SuperSystem™

Copyright © 2015 Pharmasan Labs, Inc.

3 4

While addressing individual neurotransmitter imbalances may provide symptom relief for some patients, getting to the root cause of those neurotransmitter imbalances is the only way they will achieve long-lasting results.

Personalized interventions based on: � Individual neurotransmitter results = quick symptom relief

� Network interpretation = positive, long-term health outcomes

Made possible by proprietary algorithms and a database of over 6 million test results, NeuroScience can identify the influence of 5 networks on neurotransmitter levels, helping you get to the root cause of your patient’s often complex

and recurring symptoms.

Networks include: � Sympathetic tone

� Adrenal function

� Immune activation

� Oxidative stress

� Central/neural stress

Network interpretations will be included for all pre-configured neurotransmitter profiles included in this catalog.

Pharmasan Labs tests can be ordered through NeuroScience, Inc., our partner in providing health care practitioners with access to tests for the nervous, endocrine and immune systems.

Getting started is as easy as...

Specimen turnaround time

Our partner, NeuroScience, Inc., offers practitioners complimentary one-on-one assistance with test result interpretation and questions about laboratory services.

Toll free: 888-342-7272

Tel: 715-294-2144 USA

Clinical support hours:

8:30 AM to 5:00 PM (CST)

Network Interpretationby NeuroScience, Inc.

Assess & Address™The path to personalized patient care

Getting Startedwith Pharmasan Labs, Inc.

1

2

3

START

ENJOY LONG-TERM HEALTH

Assess to identify the unique imbalances contributing to your patients' symptoms. Biomarker assessment tools from Pharmasan Labs, Inc. evaluate the function of multiple body systems. NeuroScience provides network interpretations and clinical support.

Address to restore balance and relieve symptoms. Utilize Pharmasan Labs test results to develop individualized treatment programs for your patients based on their unique imbalances.

Adjust to improve long-term patient outcomes. Additional testing helps identify and address the root cause of patient symptoms.

Practitioners can develop personalized treatment programs using an Assess & Address model.

Learn more about Network Interpretations from Dr. Gottfried Kellermann at www.neuroscienceinc.com/network

Assess

Address

Adjust

Aug 29, 1977 (37

123456

Pharmasan Labs, Inc. - Lab Request 765571 (John Doe)

NeuroScience, Inc.

375 280th Street

Osceola, WI 54020

373 280th Street, Osceola, WI 54020

1-888-342-7272 - www.pharmasan.com

Lab Request ID

Samples Received

5/4/2015 2:59 PMReported on 4/22/2015

Health Care ProfessionalPatient

John Doe

123 Anywhere St

New York, NY 10065

Date of Birth (Age))

GenderMale

Wake upN/A

Additional Contact information

Order Details

Panel 9128 (NeuroAdrenal Expanded)

ICD code 780.50,784.0,780.79

* wake up time of 7:00 AM is assumed if not provided

Results

Neurotransmitters

Units

ResultCollected

Reference Rangeµg/gCr

149.504/16/2015 (8:07AM)

34.2 - 208.2

Serotonin LDT

µg/gCr

3,477.504/16/2015 (8:07AM)

915 - 7241

5-HIAA LDT

µMol/gCr

6.404/16/2015 (8:07AM)

2 - 11

GABA LDT

µMol/gCr

44.6 (L)04/16/2015 (8:07AM)

46.1 - 673

Taurine LDT

µMol/gCr

991.004/16/2015 (8:07AM)

330 - 2342

Glycine LDT

µMol/gCr

42.204/16/2015 (8:07AM)

10.3 - 78.1

Glutamate LDT

µg/gCr

12.204/16/2015 (8:07AM)

6.9 - 33.2

Histamine LDT

nMol/gCr

66.904/16/2015 (8:07AM)

14.9 - 87.2

PEA LDT

µg/gCr

137.904/16/2015 (8:07AM)

72 - 297.2

Dopamine LDT

µg/gCr

411.704/16/2015 (8:07AM)

150.5 - 1888.4

DOPAC LDT

µg/gCr

41.204/16/2015 (8:07AM)

15 - 74.8

Norepinephrine LDT

µg/gCr

4.3 (L)04/16/2015 (8:07AM)

4.7 - 20.8

Epinephrine LDT

Reference Range is defined as the 95th percentile.

Range change effective 2/25/2015 for the following parameters: Serotonin, 5-HIAA, GABA, Taurine, Glycine, Glutamate, Histamine, PEA, Dopamine, DOPAC,

Norepinephrine

Incorrect sample submission or shipment may affect results. Results cannot be used in Legal Proceedings. LDT = Laboratory Developed Test / Not FDA Approved. Results are not intended to diagnose, treat, cure, or

prevent any disease or replace medical advice/treatment from a qualified healthcare provider. LDT** = Laboratory Developed Test with ASR: This test was developed and its performance characteristics determined

by Pharmasan Labs. It has not been cleared or approved by the US Food and Drug Administration. RUO = Research Use Only. Test results are not to be used for treatment or diagnostic purposes.

Medication use may affect urinary neurotransmitter levels (www.pharmasan.com).

1 Pharmasan Labs, WI (CLIA# 52D0914898, NY Lab PFI # 7426)

Laboratory tests performed by:

Page 1 of 3

Laboratory Director: Gottfried Kellermann, PhD

37)Male

Aug 29, 1977 (

Lab Request ID: 123456

Personalized Assess & AddressTM Recommendation for

John Doe

373 280th Street, Osceola, WI 54020

1-888-342-7272 - www.neuroscienceinc.com

Panel 9128 (NeuroAdrenal Expanded)

Patient

NeuroScience, Inc.375 280th StreetOsceola, WI 54020 John Doe123 Anywhere StNew York, NY 10065 Date of Birth (Age)Gender

Samples Received

5/4/2015 2:59 PM

Reported on

4/22/2015

Health Care Professional

Network Interpretation

Sympathetic Tone

Immune Activation

Oxidative Stress

Central Imbalance

Very LowLow

Normal

NormalElevated

HighNot Present

ElevatedHigh

Not PresentElevated

High

Immediate action is recommended to address concerns such as

Cardiovascular health, Anxiousness, Fatigue, Sleep difficulties, Mood

issues, Weight management problems, Constipation

Fatigue, Sleep difficulties, Symptoms of endocrine imbalances, Weight

management problems, Poor memory, Focus issues, Aches, Discomfort

Low mood, Weight management issues, Cravings, Anxiousness, Poor

memory, Headaches, Sleep difficulties, Focus issues, Irritability

Commonly Associated Symptoms ElevatedAdrenal Function Very Low Sub-

optimal NormalFatigue, Weight management problems, Difficulty managing stress.

Elevated

Sympathetic toneSympathetic tone can be compared to the idling speed of the body. Sympathetic activity is responsible for the up/down regulation of organ and endocrine

function in response to internal and external signals. It also initiates the ‘fight-or-flight’ response if necessary.

Adrenal FunctionAdrenal function is linked to sympathetic tone. Sympathetic activity initiates HPA activity, which in turn, helps to regulate the stress response.

Immune ActivationImmune activation is the response of the immune system to internal/external challenges. This immune activation can impact sympathetic tone, adrenal

function, and endocrine function. If immune activity is present, it may not be possible to restore balance to these other systems and resolve symptoms

until immune health is restored. Oxidative StressOxidative stress is primarily a by-product of immune activation or life style. The impact of oxidative stress is widespread. Excess free radicals can

interfere with various pathways in the body, including those that affect neurological and endocrine function.

Central ImbalanceCentral imbalance primarily results from peripheral imbalances and may lead to various neurological manifestations. While central control directs the

activity of the body and organs, it is also affected by events and imbalances in the periphery. Peripheral measurement of key neurotransmitters can

provide insight into the function of central neurotransmitters: central and peripheral nervous systems are an integrated unit.

Network Explanation

Note: Supplementation can lead to elevated results and can affect network interpretation. Please review the patient history for supplementation.

2Order Your Lab

Test Collection Kit

3Review LabTest Results

1Identify

Your Patient

� Fatigue, sleep difficulties, mood disorders and more

� Online at www.neuroscienceinc.com (account login required)

� Phone toll-free 888-342-7272 (Mon-Fri 7 AM - 5 PM CST)

� Order Form on page 28 (fax to 715-294-3921)

� You can ship to your office or directly to your patient.

� View online (login required)

� Email directly to your office

� Urine/Saliva - 5 to 7 business days

� Serum – 7 to 10 business days

� Whole Blood - 10 to 14 business days

� Saliva Disc – 5 to 7 business days

� TIC-KIT - 10 to 14 business days

5 6

Neurotransmitters

Epinephrine • •Norepinephrine • •Dopamine •Serotonin • •Glycine • •Taurine •Glutamate • •PEA • •Sulfite •Kynurenic Acid •

Hormones

Cortisol x 4 (Saliva) •DHEA •

SNPs

MTHFR (p.Ala222Val) •MTHFR (p.Glu429Ala) •COMT (n.-1324A>G) •MTR (c.2756A>G) •MTRR (MSR) (c.66A>G) •CBS (c.699C>T) •CTH (g.426A>G) •CTH (c.1208G>T) •MAO-A (p.Arg297=) •

Every patient is unique and so are the imbalances behind their symptoms.

New condition-specific 360o programs feature tests that assess

the various biomarkers contributing to some of the most

common clinical complaints.

Our Personalized Health 360o profiles on the following pages were developed with input provided

by our Clinical Advisory Board healthcare practitioners, and

our own 20 years of experience, to offer a revolutionary and

objective “whole systems” approach to rapidly assess multiple

systems imbalances.

Customize Your Patient's 360o profile Multi-option test collection kits and requisition forms allow

practitioners the option to perform numerous tests and profiles

using a minimum number of specimens, requisition forms, and

return shipment boxes. Multiple profile options are included on

a single modular requisition form.

Sleep 360

Anxiousness

360

Mood 360

Cardio 360

Fatigue 360

Sleep360o

Mood360o

Fatigue360o

Cardio360o

Anxiousness360o

Personalized Health 360o Programs

Sleep 360

Anxiousness

360

Mood 360

Cardio 360

Fatigue 360

Sleep360o

Mood360o

Fatigue360o

Cardio360o

Anxiousness360o

Our Sleep 360o Program takes the guesswork out of sleep treatment protocols by providing an objective measurement of the primary biomarkers and genetic tests related to the sleep/wake cycle.

As experts in the field of sleep disorder assessments for more than fifteen years, we provide results practitioners can trust.

When to use

Sleep 360o is recommended for patients with insomnia, restless sleep, and those who have difficulty initiating or maintaining sleep .

Fatigue is often considered to be an endocrine disorder alone; and many testing and treatment regimens focus only on the adrenal gland (cortisol and DHEA). This approach may be helpful to some, but it overlooks other potential causes of fatigue. Our Fatigue 360° Program provides a comprehensive assessment that includes biochemical markers and tests to identify neurologic and regulatory imbalances, combined with adrenal gland assessment that can guide practitioners when creating more personalized and individualized treatment programs for their patients’ long-term well-being.

When to use

Fatigue 360o is recommended for patients with low energy, fatigue, brain fog/cognitive difficulties, and those who feel tired and unrefreshed.

When it comes to mood disorders it is commonly assumed they are likely caused by one individual neurotransmitter imbalance or dysregulation such as serotonin or dopamine, or that a hormone level may be “off” due to aging or menopause. Our comprehensive Mood 360° Program provides a comprehensive assessment of key neurotransmitters and hormones, as well as providing additional analysis of inflammatory markers and genetic SNPs that can affect neurotransmitter methylation, hormone synthesis, and inflammatory and oxidative stress response capabilities.

When to use

Mood 360o is recommended for patients with low mood, anxiousness, worthless/hopeless feeling, and those who display a lack of interest in things previously enjoyed, are irritable or overwhelmed.

4 Saliva, 2 Urine, 3 Saliva Discs

2 Urine, 3 Saliva Discs

Specimen Requirement

Initial #91280 Retest #91281

Sleep 360

Anxiousness

360

Mood 360

Cardio 360

Fatigue 360

Sleep360o

Mood360o

Fatigue360o

Cardio360o

Anxiousness360o

NeuroInflammatory

Endocrine

Genetics

Specimen Requirement 1 Saliva, 2 Urine, 3 Saliva Discs

2 Urine, 3 Saliva Discs

Neurotransmitters

Epinephrine • •Norepinephrine • •Dopamine •Serotonin • •Glycine • •Taurine •GABA •Glutamate • •PEA • •Histamine •

Hormones

Cortisol (Saliva) •Melatonin (Saliva) •

SNPs

MTHFR (p.Ala222Val) •MTHFR (p.Glu429Ala) •COMT (n.-1324A>G) •MTR (c.2756A>G) •MTRR (MSR) (c.66A>G) •CBS (c.699C>T) •CTH (g.426A>G) •CTH (c.1208G>T) •

Initial #91270 Retest #91271

NeuroInflammatory

Endocrine

Genetics

2 Urine, 3 Saliva Discs

Neurotransmitters

Epinephrine • •Norepinephrine • •Dopamine •DOPAC •Serotonin • • 5-HIAA •Glycine • •GABA •Glutamate • •Sulfite • •

zz

SNPs

MTHFR (p.Ala222Val) •MTHFR (p.Glu429Ala) •COMT (n.-1324A>G) •MTR (c.2756A>G) •MTRR (MSR) (c.66A>G) •CBS (c.699C>T) •CTH (g.426A>G) •CTH (c.1208G>T) •MAO-A (p.Arg297=) •

Specimen Requirement

Initial #91290 Retest #91291

NeuroInflammatory

Genetics

360o

Genetics

Central and peripheral nervous system

Immune

Cardio

Endocrine

7 8

Sleep 360

Anxiousness

360

Mood 360

Cardio 360

Fatigue 360

Sleep360o

Mood360o

Fatigue360o

Cardio360o

Anxiousness360oCardio 360° provides a revolutionary and objective “whole systems” approach to cardiac assessment that goes beyond traditional cholesterol testing.

Imbalances that impact cardiovascular health may begin long before symptoms appear and vary based on gender. Healthcare practitioners can promote cardiovascular health by identifying imbalances early.

Cardio 360° assesses the early influencers on cardiovascular health including oxidative stress, poor sympathetic tone, inflammation, endocrine health, and genetic variation. Additionally, each of these areas is assessed with respect to gender, allowing you to truly create personalized interventions that promote cardiovascular health.

Personalized Health 360o Programs

Cardio

Oxidized LDL • •APoB • •APoA1 • •APoB:APoA1 Ratio • •DOPAC •MPO • •

Neurotransmitters

Norepinephrine • •Dopamine • •Serotonin • •GABA • •Glycine •Taurine •

Cytokines

IL-6 • •IL-8 • •IL-10 • •TNF- • •GM-CSF • •IFN-g • •

Hormones

Total Testosterone •Free Testosterone •Sex Hormone Binding Globulin •Estradiol •Estrone •DHEA •

Genetics

SOD3 (p.Arg231Gly) • •CAT (g.4760C>T) • •MTHFR (p.Glu429Ala) • •MTHFR (p.Ala222Val) • •

Specimen Requirement

Cardio 360o #5320 For Him

Cardio 360o #5321 For Her

Nervous SystemNeurotransmitters are at the foundation of many psychiatric and neurological disorders and are

prime targets for addressing these disorders. External interventions can alter and improve nervous

system function. These may include pharmaceutical medications or nutritional supplements. We

offer neurotransmitter analysis in pre-configured testing profiles, in combination with endocrine

and adrenal assessments, and SNPs, or you can build your own neurotransmitter testing profile.

EndocrineSex hormones, adrenal analyis, and thyroid assessments are available. We offer salivary and serum

testing in pre-configured profiles or you can build your own hormone profile. Salivary hormone

testing allows for non-invasive specimen collection right in the patients home.

CardiovascularProviding state-of-the-art cutting edge diagnostics to aid in cardiovascular assessment. Tests

include assessment of sympathetic tone with neurotransmitter analysis, oxidation and inflammatory

markers, lipids, and more.

GeneticsGenetic variations predispose patients to impairment in biological processes that can affect the

nervous, endocrine, and immune systems. Our testing profiles provide analysis of key single-

nucleotide polymorphisms (SNPs) involved in chronic nervous system and neurological imbalances,

inflammation, and oxidative stress issues. You can also build your own profile.

ImmuneImmune system activation and oxidative stress as a by-product of immune system activity have

emerged as core issues that can cause a variety of clinical concerns. They can derail the function

of the nervous and endocrine systems and exacerbate imbalances. Tests we offer include Lyme

disease and vector-borne disease analysis, cytokine analysis, lymphocyte subset analysis, natural

killer cell activity and count, metal sensitivity, celiac testing, and more.

General HealthSimplification of serum testing services using a single multiple-option profile that includes all of our

serum tests for wellness and general health assessments including celiac disease, gluten sensitivity,

vitamin D, thyroid analysis, hormones and more.

Testing Categories

Oxidation/Lipids

Genetics

Endocrine

Inflammation

Sympathetic tone

1 Plasma, 1 Tiger Top,

2 Urine, 1 Yellow Top,

4 Saliva,3 Saliva Discs

1 Plasma, 1 Tiger Top, 1 Tiger Top with

Serum Transport Tube, 2 Urine, 1 Yellow Top,

3 Saliva Discs

When to useThese profiles are recommended for patients with:

� Digestive disorders

� Bone and joint pain

� Skin conditions

� Poor teeth and gums

� Metabolic syndrome/diabetes

� Endocrine/hormone issues/ estrogen dominance

� Chronic pain

� Sleep issues

� Depression

� Fatigue

� Chronic infections (i.e., Lyme and other hidden infections)

� Elevated lipids

9 10

NeuroScreen Expanded NeuroScreen Basic NeuroScreen Essential Build Your Own

9123 9023 9074 9900

Epinephrine • • • •Norepinephrine • • • •Dopamine • • • •DOPAC • •Serotonin • • • •5-HIAA • •Glycine • • •Taurine • •GABA • • • •Glutamate • • • •PEA • • • •Histamine • • •Kynurenic acid •Sulfite •Specimen Requirement 2 Urine 2 Urine 2 Urine 2 Urine

NeuroAdrenal Expanded + Melatonin

NeuroAdrenal Expanded

NeuroAdrenal Basic

NeuroEndocrine Comprehensive +

Melatonin

NeuroEndocrine Comprehensive

NeuroEndocrine Basic

NeuroSLP

9328 9128 9028 9608 9606 9505 9127

Epinephrine • • • • • • •Norepinephrine • • • • • • •Dopamine • • • • • • •DOPAC • • • • •Serotonin • • • • • • •5-HIAA • • • •Glycine • • • • • • •Taurine • • • •GABA • • • • • • •Glutamate • • • • • • •PEA • • • • • • •Histamine • • • • • • •Cortisol x4 x4 x4 x4 x4 x4 x1

DHEA • • • • • •Melatonin • • •Estradiol • • •Estrone • • •

Estriol • •Progesterone • • •Testosterone • • •Specimen Requirement

2 Urine, 4 Saliva 2 Urine, 4 Saliva 2 Urine, 4 Saliva 2 Urine, 4 Saliva 2 Urine, 4 Saliva 2 Urine, 4 Saliva 2 Urine, 1 Saliva

Neurotransmitter Profiles Neurotransmitter and Endocrine Profiles

� Learn more at www.neuroscienceinc.com/neurology

+ For a companion genetic assessment see profiles 59000, 59001, 59003, 59007 or 59010 on page 14.

+ For a companion genetic assessment see profiles 59000, 59001, 59002, 59003, 59006, 59009, or 59010 on page 14.

Non-hormonal approaches to “Endocrine” symptomsDue to the interactions between each system included in the NEI system, symptoms can sometimes appear as a hormone issue when in actuality, they can be attributed to a neurotransmitter imbalance. Common symptoms include mood changes, focus issues, insomnia, fatigue, or anxiety. Addressing NEI system disturbances often results in patient symptom resolution without the need for hormone replacement therapy (HRT). 

Reducing HRT levelsFor those patients that do indeed require HRT, addressing nervous and immune system disturbances concomitantly often results in a lower HRT dose and therefore reduces HRT side-effects. 

When to useThese profiles are recommended for patients with symptoms of nervous system imbalance indicated on page 9 plus:

� Fatigue

� Brain fog

� Chronic pain

� Panic disorders

� Eating disorders

� PMS

� Restless sleep

� Chronic illness

� Insomnia

� Low libido

� Personality disorders

� Hirsutism

� PCOS

� Hot flashes/cold sweats

� Andropause symptoms

� Menopause symptoms

Neurotransmitters are the primary messengers for the nervous system, which coordinates everything from the stress response to general organ function to emotion and cognitive function. What has recently come to light in the research is that the immune system also produces and uses neurotransmitters.

Imbalances in these neuro-immune markers, can disrupt normal nervous and immune system function leading to the manifestation of psychological, somatic, and mood disorders, and related clinical complaints. The profiles below assess neurotransmitter function.

When to useThese profiles are recommended for patients with:

� Moodiness

� Irritability

� Addictions

� Compulsions

� Anxiety/OCD

� Agitation

� Depression

� Headaches/migraines

� Learning disorders

� GI complaints

� ADD/ADHD

� Polypharmacy

� Autism

� Tourette Syndrome

� PTSD

� Oppositional Defiant Disorder

� Dementia/cognitive decline

� Constipation

� Unexplained weight gain

11 12

Salivary Endocrine Profiles

Serum Endocrine Profiles

Comprehensive Endocrine - Saliva

Endocrine Health Basic - Saliva

Endocrine Essential II

Endocrine Essential

Adrenal Health

Build Your Own Hormone Profile - Saliva (Choose from below)

7127 7027 7071 7070 7100 7900 (Cortisol x1) 7925 (Cortisol x4)

Cortisol x4 x4 x4 x1 x4 x1 / x4

DHEA • • • • • •Progesterone • • • • •Testosterone • • • • •Estradiol • • • • •Estrone • • •Estriol • •Melatonin • •Specimen Requirement 4 Saliva 4 Saliva 4 Saliva 4 Saliva 4 Saliva 4 Saliva

Thyroid Profile IV

Thyroid Profile III

Thyroid Profile II

Thyroid Profile I

Comprehensive Endocrine - Serum

Build Your Own Hormone Profile - Serum (Choose from below)

7022 7025 7024 7023 7044 7950

Free Triiodothyronine (fT3) • • • • •Free Thyroxine (fT4) • • • • •Thyroid Stimulating Hormone (TSH) • • • • •Thyroid Peroxidase (TPO) IgG • • • •Thyroglobulin Ab (tG) IgG • • •T3 Reverse (Triiodothyronine) (rT3) •Cortisol Thyroid assessment is suggested for patients who have suspected

thyroid disorders, autoimmune disorders, low energy, hair loss, depression, low mood, or chronic inflammation, oxidative stress or poor temperature regulation. We offer several profile configurations to meet your testing needs.

• •DHEA-S • •Estradiol • •Progesterone • •Testosterone (Total) • •Testosterone (% Free and Bioavail-able) (Requires Total and SHBG to calculate)

•

Dihydrotestosterone (DHT) •Luteinizing Hormone (LH) • •Follicle-stimulating Hormone (FSH) • •Prolactin • •Sex Hormone Binding Globulin (SHBG) • •Specimen Requirement 1 Tiger Top 1 Tiger Top 1 Tiger Top 1 Tiger Top 1 Tiger Top 1 Tiger Top

Serum hormone analysis may be preferred over saliva for patients utilizing hormone therapy and/or to evaluate total hormone levels.

Develop an individualized program with NeuroCardio testing profiles designed to specifically assess the 5 key elements of heart health.

Proper immune activity

Healthy sympathetic tone

Healthy endothelial

function

Healthy cholesterol

Antioxidant defense

5

1

3

4

2

In addition to our innovative Cardio 360o gender specific profiles (page 7), we also offer selective profiles, shown below, that assess sympathetic tone, oxidation and inflammation.

When to useThese profiles are recommended for patients with:

NeuroCardio Profiles

Salivary hormone testing is frequently used to assess baseline free hormone levels. Pharmasan Labs™ utilizes sensitive and specific ELISA, radioimmunoassay, and electrochemiluminescence methodologies for salivary hormone testing. Salivary reproductive hormones and DHEA are measured from a pooled combination of a 4-point saliva collection.

When to useThese profiles are recommended for patients with:

� Anxiety

� Lethargy

� Hot flashes

� Mood swings

� Low libido

� Acne

� Thin and/or dry skin

� Ovarian cysts

� Infertility

� Depression

� Headaches

� Unexplained weight gain

� Digestive disorders

� Bone and joint pain

� Skin conditions

� Poor teeth and gums

� Metabolic syndrome/diabetes

� Endocrine/hormone issues/ estrogen dominance

� Chronic pain

� Sleep issues

� Depression

� Fatigue

� Chronic infections (i.e., Lyme and other hidden infections)

Who is at risk? While chest pain is a sign for heart disease, it may not be a good marker for prevention of heart disease. If left untreated, chronic inflammatory issues may push the body environment to develop heart disease. The body will provide ample warning that inflammation is present. Our clinical advisory board recommends an inflammatory checklist be performed on every patient to assess their overall clinical inflammation.

NeuroCardio profiles offer practitioners an all-in-one assessment of multiple risk factors. NeuroCardio Essential offers a cost effective option, while NeuroCardio Comprehensive provides a more complete picture of progression toward a cardiovascular event.

NeuroCardio Essential

NeuroCardio Comprehensive

NeuroCardio Comprehensive

Retest

Cardio Essential

Cardio Comprehensive

5305 5306 5307 5315 5316

Oxidation Ox LDL should not be present in a healthy cardiovascular state. APoB:APoA1 ratio assess vulnerability of cholesterol to oxidize. DOPAC is the oxidized form of dopamine that assesses if free radicals are affecting the nervous system and sympathetic tone.

OxLDL • • • •APoA1, APoB, and ratio

• • • •

DOPAC • • •Sympathetic tone Optimal sympathetic activity can increase control over inflammation and the ability to deliver

antioxidant protection from the nerve endings of the sympathetic system to the tissues

Norephinephrine • • •

Cardio profiles for those who have already assessed sympathetic tone

Serotonin • • •Glycine • • •Taurine • • •Glutamate • • •Inflammatory cascade, plaque buildup/rupture

MPO, hs-CRP, and oxLDL are key numbers in risk stratification. Cytokines can assess both a risk for atherosclerotic build up and plaque rupture, which can lead to a heart attack

MPO • • • •Hs-CRP • • • •IL-6 • • •IL-8 • • •IL-10 • • •IL-17 (A) • • •TNF- • • •Specimen Requirement

1 Lavender Top, 1 Tiger Top, 2

Urine

1 Lavender Top, 1 Tiger Top, 2

Urine

1 Yellow Top, 2 Urine

1 Lavender Top, 1

Tiger Top

1 Lavender Top, 1 Yellow Top, 1 Tiger Top

Balanced sympathetic tone is essential for optimal heart health.

+ For a companion genetic assessment see profiles 59000, 59001, 59003 and 59010 on page 14.

13 14

Add genetic testing for patients who have complex or recurring symptomology.

These patients may have SNPs interfering with their care. For example, those who’ve already had neurotransmitter testing performed, but who are not responding as well as desired to treatment may have a SNP in an enzyme affecting neurotransmitter synthesis or metabolism. These individuals may need additional support to properly regulate neurotransmitter levels.

The table below shows the effects several SNPs may have on neurotransmitter levels:

SNPsPotential Effects on

Neurotransmitter Levels

Potential Clinical Effect

SOD2 (p.Val16Ala)

Dopamine

Norepinephrine

Serotonin

• Low mood• Fatigue• Focus issues• Cravings• Poor muscle control

GPX1 (p.Pro200Leu)

COMT (n.-1324A>G)

Dopamine

Norepinephrine

Epinephrine

• Anxiousness• Sleep difficulties• Excess energy

MTHFR (p.Ala222Val)

Dopamine

Norepinephrine

Epinephrine

Serotonin

• Mixed clinical effects, depending on presence of other SNPs and patient stressors

MTHFR (p.Glu429Ala)

COMT (n.-1324 A>G)

MTHFR (p.Ala222Val)

MTHFR (p.Glu429Ala)

Dopamine

Norepinephrine

Epinephrine

Serotonin

• Anxiousness• Sleep difficulties• Fatigue• Excess energy• Low mood• Focus issues

+ Look for the companion Functional Genetics assessment recommendations throughout this catalog.

Genetic variation ≠ symptoms

While genetic testing lets you know if a genetic variation in the form of a single nucleotide polymorphism (SNP) is present or not, it does not, for most genes, tell you if that SNP is impacting your patient’s health. The body has many built-in redundancies, so even though a SNP is present, another system or an individual's lifestyle may be adequately compensating for the variation.

How can you know if genetic variation is contributing to your patient’s symptoms?

That’s the purpose of functional genetics. It combines traditional genetic testing with the corresponding biochemical assessments. You can use the information from these results to create highly personalized therapeutic protocols for your patients.

Functional Genetics Testing - A New Approach

Functional

Biochemical assessment Genetic testing

Genetics

Genetics

Profile Name Profile # SNPs (rs #) (Position) NameFunctional Genetics

(recommended companion profile)

Celiac Disease 59002 • HLA-DQ2.5 (rs2187668) (c.82+567C>T)• HLA-DQ8 (rs7454108) (g.32681483T>C)

• Human leukocyte antigen - isoform• Human leukocyte antigen - isoform

• 5099 Endomysial Antibody profile• 5056 Gluten Sensitivity/Celiac Screen• NeuroAdrenal profiles 9094, 9028,

9128, 9328

Detoxification 59008 • GSTM1 (CNV) (1p13.3)• GSTP1 (rs1695) (p.IIe105Val)

• Glutathione S-transferase mu 1• Glutathione S-transferase pi 1

• MELISA metal sensitivity

Homocysteine Metabolism/Methylation/ Glutathione Synthesis*

59006 • CBS (rs234706) (c.699C>T)• CTH (rs482843) (g.426A>G)* • CTH (rs1021737) (c.1208G>T)*

• Cystathionine-beta-synthase• Cystathionine-gamma-lyase

• NeuroEndocrine profiles 9093, 9505, 9606, 9608

• MTR (rs1805087) (c.2756A>G)• MTRR (rs1801394) (c.66A>G)• GCLC (rs17883901)*• GCLM (rs2301022)*

• 5-methyltetrahydrofolate-homocysteine methyltransferase/methionine synthase

• 5-methyltetrahydrofolate-homocysteine methyltransferase reductase/ methionine synthase reductase

• Glutamate-cysteine ligase, catalytic subunit• Glutamate-cysteine ligase, modifier subunit

• NeuroAdrenal profiles 9094, 9028, 9128, 9328

Inflammation* 59009 • IL6 (rs1800795)*• IL10 (rs1554286)*• TNF (rs1800629)*• IFNG (rs2069727)*

• Interleukin 6• Interleukin 10• Tumor necrosis factor• Interferon gamma

• NeuroAdrenal profiles 9094, 9028, 9128, 9328

Multiple Drug Resistance 59005 • MDR1 (ABCB1) (rs1045642) (c.3435T>C)

• Multidrug Resistance/ATP-binding cassette, sub-family B (MDR/TAP), member 1

• 5089 Inflammatory Cytokine Basic profile

Neurotransmitter Synthesis and Degradation Pathway*

59007 • MAO-A (rs6323) (g.Arg297=)• MAO-B (rs1799836) (g.118723A>G)• TH (rs107700141)*• TH (rs10770140)*• eNOS (rs1799983) (c.894T>G)• eNOS (rs2070744) (g.6933C>T)

• Monoamine oxidase A• Monoamine oxidase B• Tyrosine hydroxylase• Tyrosine hydroxylase• Endothelial nitric oxide synthase• Endothelial nitric oxide synthase

• 9123 NeuroScreen Expanded

Neurotransmitter Synthesis / Methylation

59003 • COMT (rs6269) (n.-1324A>G)• MTHFR (rs1801131) (p.Glu429Ala)• MTHFR (rs1801133) (p.Ala222Val)

• Catechol-O-Methyltransferase• Methylenetetrahydrofolate reductase • Methylenetetrahydrofolate reductase

Profiles containing: • Epinephrine• Norepinephrine• Dopamine• Serotonin

Oxidative Stress 59000 • SOD1 (rs4998557) (g.7958G>A)• SOD1 (rs2070424) (g.12386A>G)• SOD2 (rs4880) (p.Val16Ala)• SOD3 (rs1799895) (p.Arg231Gly)• CAT (rs1001179) (g.4760C>T)• GPX1 (rs1050450) (p.Pro200Leu)

• Superoxide dismutase 1• Superoxide dismutase 1• Superoxide dismutase 2• Superoxide dismutase 3• Catalase• Glutathione peroxidase 1

Profiles containing: • Epinephrine• Norepinephrine• Dopamine• Serotonin• DOPAC • 5-HIAA• Kynurenic acid • Sulfite

Tryptophan Pathway* 59010 • IDO1 (rs9657182)*• KMO (rs1053230)*• AADAT (KAT2) (rs1480544)*

• indoleamine 2,3-dioxygenase 1• kynurenine 3-monooxygenase• aminoadipate aminotransferase/kynurenine

aminotransferase II

Profiles containing: • Serotonin• 5-HIAA• Kynurenic acid• Cortisol• Glutamate

Vitamin D3 59001 • GC (rs2282679) (c.26-796A>C)• GC (rs2298849) (c.58+827T>C)• VDR (rs1544410) (c.1024+283G>A)• CYP27B1 (rs10877012) (g.58162085G>T)

• group-specific component (vitamin D binding protein)

• group-specific component (vitamin D binding protein)

• vitamin D receptor• cytochrome P450, family 27, subfamily B,

polypeptide 1

• 4028 25-OH Vitamine D profile• Any neurotransmitter panel,

Testosterone for men

Specimen Requirement (all profiles) 3 Saliva Discs * Coming soon

Learn more

� In the Physician Resources section of our website

� On the U.S. National Library of Medicine’s Genetics Home Reference Library at http://ghr.nlm.nih.gov/

Identification of an individual’s genetic function creates an opportunity for personalized lifestyle modification, and as necessary, targeted therapeutic interventions. To simplify your genetic testing needs, all of the following pre-configured genetic test profiles and individual genetic SNPs are available on one test requisition form.

+Genetic testing can be added at any point in care and does not need to be repeated, as genetics do not change regardless of interventions.

Biochemical assessment

Genetic testing

15 16

Inflammation and Oxidative Stress

Oxidative Stress AnalysisOxidative stress can damage DNA, proteins, and lipids, contributing to disorders such as cancer, Parkinson's, atherosclerosis, chronic fatigue syndrome, Lyme disease, and other vector-borne diseases.

The profiles listed below offer several options for assessment of oxidative stress and inflammation. A multi-option requisition form allows healthcare practitioners options to choose from pre-configured profiles, or to mix and match to provide a more personalized approach.

Mitochondrial Function TestingExcessive mitochondrial superoxide is believed to be one of the main contributors to oxidative stress and cell damage.

The predominant generator of reactive oxygen species (ROS) within the cells is the mitochondria and it is believed that the major contributor to cellular oxidative damage is mitochondrial superoxide. Low baseline mitochondrial membrane potential results in a decreased capacity to defend against excessive ROS, which can lead to oxidative stress.

When to use Mitochondrial Superoxide � Assessment of Redox status (inflammation and oxidative stress, viral or bacterial infection)

� Monitoring treatment of a disease or disorder (Borrelia infection, treatment of inflammation)

� Functional correlation with Antioxidant SNP results

When to use Mitochondrial Membrane Potential � Assessment of baseline potential (starting point for defense of excessive ROS, effect of environmental insults)

� Assessment and monitoring treatment of a disease or disorder (viral or bacterial infection, cardiovascular disease)

Sensitivities

MELISA® (MEmory Lymphocyte Immuno-Stimulation Assay)

What is MELISA?MELISA® measures Type-IV delayed hypersensitivity reaction to foreign materials (metal antigens). A Type-IV hypersensitivity reaction is mediated by memory T-lymphocytes that had contact with a given foreign material. Even sub-toxic levels of metals can cause Type IV delayed hypersensitivity. The MELISA test results can indicate hypersensitivity, prior exposure, and/or potential presence of metal antigens.

When to useFor patients with symptoms of metal hypersensitivity or who may have been exposed to metals present in:

� Dental amalgams and implants

� Orthopedic and electrical implants

� Jewelry

� Food and cookware

� Thimerosal (a preservative in some vaccines)

� Through environmental or occupational exposure

� Learn more at www.neuroscienceinc.com/melisa

+ For a companion genetic assessment see profile 59008 on page 14.

MELISA® Profiles

55602 Dental and Amalgam

55605 Implants

55607 Mercury

55600 Metals I

55612Metals II

55609* Implants

Expanded

Aluminum • •Chromium • •Cobalt • •Copper • •Ethylmercury •Gold • •Inorganic mercury •

Methylmercury •Molybdenum • •Nickel • • •Phenylmercury •Silver • •Thimerosol •Tin • •Titanium Calcium •Titanium Dioxide • •Titanium Sulfate •

Vanadium • •Zirconium •Specimen requirements

4 Yellow Top 6 Yellow Top 5 Yellow Top 5 Yellow Top 4 Yellow Top 3 Yellow Top

Please order using the MULTI-MELISA multi-option requisition form.

Gluten Sensitivity/Celiac ScreenWhat is Celiac disease? Celiac disease affects 1 in 100 people in the world, but the identification of this disease is frequently missed and/or delayed. If not identified and treated, Celiac disease can lead to disruption of multiple organ systems and a number of serious health issues. To maintain optimal health, individuals with Celiac disease must permanently remove gluten from their diet.

How is gluten sensitivity different? Not everyone with gluten sensitivity has Celiac disease. Many people have developed intolerance to gluten due to poor GI health, specifically the breakdown of the intestinal walls. Unlike Celiac disease, gluten sensitivity is usually not a life-long condition. In the majority of cases, gluten can be reintroduced into a diet after a period of avoidance, and sensitivity can be dramatically reduced or even eliminated.

The following testing profile is available to assist you with the identification of these common disorders.

MELISA® is a registered trademark of the MELISA Medica Foundation.

5056 Gluten Sensitivity/Celiac Screen

Gliadin IgA, IgG

Transglutaminase (tTG) IgA, IgG

Specimen Requirement 1 Tiger Top

+ For a companion genetic assessment see profile 59002 on page 14.

Cellular Cytokine AnalysisActivated immune cells release cytokines, which cause many of the symptoms of inflammation. Cellular cytokine analysis provides information about inflammation and immunosuppression. Stimulated cytokine levels differ dramatically from baseline in acute and chronic pathological conditions. In many disease states, marked local inflammatory responses cause cytokines to spill into general circulation, resulting in detectable levels. Changes in the circulating levels of these proteins have been linked to many disease states, making them valuable functional biomarkers.

When to useExcessive or diminished cytokine levels are associated with many clinical conditions and diseases, including, but not limited to:

� Allergies

� Asthma

� Autoimmunity

� Bacterial infections

� Cardiac disorders

� Diabetes

� Fibromyalgia

� Hypersensitivities

� Tumors

� Toxicity

� Viral infections

� Immune system activation

� Central nervous system disorders

� Additional cytokines and stimulations are available. Call to inquire 888-342-7272.

� Learn more at www.neuroscienceinc.com/cytokines

+ For a companion genetic assessment see profiles 59005 and 59009 on page 14.

5114 Cytokine

Basic

5115 Cytokine

Basic + LPS

5116 Cytokine Basic + LPS + Candida

IL-2 • • •IL-6 • • •IL-8 • • •IL-10 • • •IL-17 • • •IFN- • • •TNF- • • •Baseline • • •LPS • •Candida •Specimen requirements

1 Yellow Top 1 Yellow Top 1 Yellow Top

Oxidative Stress/Inflammation

9099 Basic

90990 Expanded

90991 Expanded with SNPs

NeurotransmittersDOPACGlycineGlutamateKynurenic AcidSulfite

• • •

Mitochondrial Superoxide* • •Mitochondrial Membrane Potential* • •Genetic SNPsSOD1 (rs4998557) (g.7958G>A) SOD1 (rs2070424) (g.12386A>G) SOD2 (rs4880) (p.Val16Ala) SOD3 (rs1799895) (p.Arg231Gly) CAT (rs1001179) (g.4760C>T) GPX1 (rs1050450) (p.Pro200Leu

•

Specimen requirements 2 Urine2 Urine

2 Yellow Top

2 Urine2 Yellow Top3 Saliva discs

* Coming soon

* Coming soon

17 18

iSpot testing bridges the gap left by antibody tests by measuring the cellular response to antigens. Tests that only measure antibody response can produce false negative results 50 - 70% of the time. In addition, antibody response can only identify exposure to the infectious agent, but does not identify status of infection.

iSpot testing measures something completely different - T cell response to specific antigens. Unlike antibody production, T cell response kicks in just 4–6 days after infection. As a result, iSpot allows for earlier detection than antibody based testing. Increased sensitivity over other methodologies is due to the proven ability of this test methodology to analyze and identify infected cells at a rate of one infected cell per million cells.

iSpot: � Monitors progress and efficacy of treatment

� Aids in early diagnosis and treatment of vector-borne disease (within one to two weeks)

� Identifies recurring infections

� Provides high specificity (94% iSpot Lyme) and sensitivity (84% iSpot Lyme)

� Has rapid turn-around time for test results

Immune

iSpot Lyme recombinant protein antigens:

DbpA Early stage antigen: Contributes to spirochete dissemination within the host

OspC Early stage antigen: Appears shortly after tick bite and transfer of the spirochete

VlsE-1 Upregulated in the host, particularly during immune response

p100 Late stage antigen

* Coming soon ** Source: www.cdc.gov accessed April 1, 2015 ** Source: www.cdc.gov accessed April 1, 2015

5200 iSpot Lyme™

5201 iSpot Lyme™ with

Western Blot

DbpA, OspC, p100, VlsE-1 • •Western Blot IgG, IgM •Specimen requirements 2 Yellow Top 2 Yellow Top, 1 Tiger Top

5215 iSpot™ Lyme with iSpot™

Babesia*

5205 iSpot™

Babesia*

5206 Babesia microti

Antibody Panel

Babesia P41, P32, IRA • •Borrelia DbpA, OspC, p100, VlsE-1 •Babesia IgG, IgM •Specimen requirements 4 Yellow Top 2 Yellow Top 1 Tiger Top

BabesiaBabesia microti is transmitted by Ixodes scapularis ticks (blacklegged deer ticks). It can also be transmitted congenitally, or via blood transfusion. Babesia has been reported nationwide, with prevalence being highest in locations where blacklegged deer ticks are most commonly found.**

This indirect fluorescent antibody (IFA) test provides detection and semiquantitation of human serum IgG and IgM antibodies to babesia and aids in the diagnosis of human babesiosis.

LymeLyme disease is caused by Borrelia burgdorferi, a bacterium of the spirochete class, which is transmitted by the Ixodes tick or via blood transfusion. The blacklegged tick (or deer tick, Ixodes scapularis) spreads the disease in the northeastern, mid-Atlantic and north-central United States, and the western blacklegged tick (Ixodes pacificus) spreads the disease on the Pacific Coast. Babesia has been reported nationwide, with prevalence being highest in locations where blacklegged deer ticks are most commonly found.**

� Learn more at www.ispotlyme.com

Vector-borne Disease Testing

Ehrlichia/AnaplasmaEhrlichia chaffeensis and Ehrlichia ewingii are transmitted by the lonestar tick (Amblyomma americanum) found in the southeastern and southcentral United States.**

Synonyms: Anaplasma phagocytophilia; Ehrlichia; HE

This indirect fluorescent antibody (IFA) test provides detection and semiquantitation of human serum IgG and IgM antibodies to human granulocytic ehrlichiosis (HGE) and aids in the diagnosis of human granulocytic ehrlichiosis.

5210 Human Granulocytic Ehrlichiosis (HGE)

HGE IgG, IgM

Specimen Requirement 1 Tiger Top

BartonellaCat Scratch disease (from Bartonella henselae) comes from the scratch of infected cats and kittens, domestic and feral. These cats are typically infected by fleas that carry the bacteria. Scientists are exploring whether infected fleas can infect humans when they bite them.** Ticks may carry Bartonella bacteria, and scientists are currently researching if they can also transmit the infection to humans. Trench Fever (from B. quintana) is transmitted by the human body louse. Both Cat Scratch disease and Trench Fever can be found worldwide.**

This test is intended to be used as an aid in the diagnosis of infections caused by Bartonella henselae or Bartonella quintana.

5207Bartonella Antibody Panel

Bartonella henselae IgG, IgM

Bartonella quintana IgG, IgM

Specimen Requirement 1 Tiger Top

This indirect fluorescent antibody (IFA) test provides detection and semiquantitation of human serum IgG and IgM antibodies to human monocytic ehrlichiosis (HME), and aids in the diagnosis of human monocytic ehrlichiosis.

5209 Human Monocytic Ehrlichiosis (HME)

HME IgG, IgM

Specimen Requirement 1 Tiger Top

5211 Rocky Mountain Spotted Fever (RMSF)

RMSF IgG

Follow up titers for positive or equivocal titers by IFA reflex

Specimen Requirement 1 Tiger Top

Rocky Mountain Spotted Fever, IgGRocky Mountain Spotted Fever is caused when Rickettsia Rickettsii is transmitted via the bite of the American dog tick (Dermacentor variabilis), Rocky Mountain wood tick (Dermacentor andersoni) or the brown dog tick (Rhipicephalus sanguineus). Rocky Mountain Spotted Fever has been reported nationwide.**

Synonyms: Rickettsia rickettsii, R. rickettsii, RMSF

This test can be used as an aid to establish the diagnosis of infection due to Rickettsia in the spotted fever group. The antigen used in the test is group specific, not species specific.

+ For a companion genetic assessment see profile 59009 on page 14.

ImmuneMemory

Antigen (borrelia, babesia, bacteria, etc.)

MemoryT cells

E�ectorT cells

NaiveT-helper cell

MHCmolecule

NaiveB cell Plasma B cells

= Cytokines

Cytokineimmune response

Humoral immune response

Cellular immune response

Receptor

Antigenpresenting cell

Antibodies(Ab)

ImmuneChallenge

Days Weeks Months Years

Mem

ory

T ce

lls

IgM

Ab

IgG A

b

Cyt

okin

esE�

ecto

r T ce

lls

Timeline of Immune Response

Immune Cell Response

Vector-borne diseases can cause: � Many neuro-psychiatric manifestations and clinical symptoms

+ For companion diagnostics see our neurotransmitter profiles on page 9 and 10.

� Inflammation, and oxidative stress, as a by-product of immune system activity

+ For companion diagnostics see the profiles we offer on page 15.

19 20

Pharmasan Animal Health, an affiliate of Pharmasan Labs, is pleased to introduce the TIC-KIT.The TICKIT provides an all-in-one solution for tick removal and tick testing:

� Tick removal device for easy tick collection

� Storage container

� Tick identification card

� Pre-paid shipping

� Laboratory PCR assessment of the tick for Borrelia, Babesia, Bartonella, and Ehrlichia (Anaplasma)

� Online test results

TIC-KIT™ Immune Profiles

Learn more at www.tic-kit.com

animal health

Natural Killer (NK) CellsNatural killer cell count and activity assessment can identify if your patient has the ability to fight off infections, bacteria, parasites, cancer, and more.

NK cell activity and NK cell count are NOT the same. NK cells may be present in sufficient numbers (count), but unless they are activated (activity) they are ineffective in performing their job. Decreased NK cell activity is linked to the development and progression of many diseases.

NK cells are critical for targeting and killing virus-infected and cancerous cells. NK cell testing is recommended when viral or bacterial infections are suspected, as well as for monitoring cancer patients, who may be at greater risk if NK cell activity is reduced. To learn more, see http://tinyurl.com/nk-cells-interp

3014 NK Cell Activity

5067 NK Cell Activity and Count

Natural Killer Cell Activity (Chromium Release Assay) • •

Absolute and Percentage CD16+/CD56+ NK Cells •

Specimen requirements 1 Yellow Top 1 Yellow Top, 1 Lavender Top

Lymphocyte Subset Analysis (LSA)Abnormal lymphocyte counts and ratios indicate that immunological imbalances may be contributing to patient symptoms.

3013 LSA

Absolute Lymphocytes

Absolute and % CD3+ cells (T cells)

Absolute and % CD3+/CD4+ cells (T helper cells)

Absolute and % CD3+/CD8+ cells (Cytotoxic T cells)

CD4+/ CD8+ (Helper/Cytotoxic T cell ratio)

Absolute and % CD19+ cells (B cells)

Absolute and % CD16+/CD56+ cells (Natural Killer cells)

Specimen Requirement 1 Lavender Top

� These tests are not suggested for patients on immunosuppresant therapy.

+ For a companion genetic assessment see profile 59000 or 59009 on page 14.

Column A

5056 – Gluten Sensitivity/Celiac Screen: Gliadin IgG, IgA, tTg IgG, IgA

Choose Only One Thyroid Profile

7023 – Thyroid Profile I: fT3, fT4, TSH

7024 – Thyroid Profile II: fT3, fT4, TSH, TPO

7025 – Thyroid Profile III: fT3, fT4, TSH, TPO, TG

7044 – Comprehensive Endocrine: Testosterone, Estradiol, Cortisol, DHEA-S, Progesterone, LH, FSH, Prolactin, SHBG

7046 – Lipid Profile: Total Cholesterol, Triglycerides, HDL, LDL

4029 – Vitamin B12

4106 – Basic Metabolic Profile

4107 – Comprehensive Metabolic Profile

+ For a companion genetic assessment see profiles 59001, 59002 or 59006 on page 14.

Column B

4028 – 25-OH Vitamin D

8043 – hs-CRP

8032 – Ferritin

8186 – Prostate Specific Antigen (total)

8074 – Insulin (fasting)

3002 – Lyme Western Blot IgG, IgM

7950 Build Your Own Hormone Profile

Cortisol Follicle-stimuilating Hormone (FSH)

DHEA-S Prolactin

Estradiol Sex Hormone-Binding Globulin (SHBG)

Progesterone Free Triiodothyronine (fT3)

Testosterone (Total) Free Thyroxine (fT4)

Testosterone (%Free and Bioavailable – requires Testosterone Total and SHBG)

Thyroid-stimulating Hormone (TSH)

Dihydrotestosterone (DHT) Thyroid Peroxidase (TPO)

Luteinizing Hormone (LH) Thyroglobulin (tG)

See Thyroid Profiles left

Wellness TestingWe offer several options for wellness and "routine" annual health examinations on a modular multi-option test profile that allows you to choose from our preconfigured profiles or build your own by selecting individual test parameters.

Maximum allowed: � 5 from Column A OR

� 3 from Column A and up to 20 from Column B

7985 MULTI-SER1

Specimen Requirement 2 Tiger Top

General Health

CBC and HbA1C are available. Order profile #7988. Profile requires refrigerated cool pack and overnight shipment to the laboratory.

T10002 TIC-KIT

Specimen Requirement Tick

TIC-KIT is prepay only.

T10004 TIC-KIT Retail Display StandAvailable with 8-pack TIC-KIT purchase while supplies last.

Additional animal testing services are available. Inquire by calling customer service at 888-342-7272.

21 22

Methylation and Cysteine Cycles

Endocrine Pathway

Progesterone

Cortisol

cholesterol monooxygenase

21-hydroxylase

17α-hydroxylase

17α-hydroxylase

11β-hydroxylase

3β-hydroxysteroiddehydrogenase

estradiol 17β-dehydrogenase

steroid 16α-hydroxylase

steroid 16α-hydroxylase

17β-hydroxysteroiddehydrogenase

17β-hydroxysteroiddehydrogenase

Cholesterol Pregnenolone

DHEA

17-Hydroxypregnenolone

17-Hydroxyprogesterone

17, 20 desmolase

17, 20 desmolase

11-Deoxycortisol

aromatasearomatase

5α-reductase

Androstenedione

Estriol

Estrone Estradiol

Testosterone

Dihydrotestosterone

Orange text indicates parameters tested Red text indicates cofactors Purple text indicates SNPs tested

Tryptophan PathwayTransmethylation

Transsulfuration

Glutathione Biosynthesis

Endocrine Pathway

Catecholamine Pathway

Pathways

Cystathionine

Cysteine

α - Ketobutyric acid

& Ammonia

Hydrogen Sulfide

Thiosulfate

3-Sulfinyl-pyruvateSulfite

ETC

Sulfate

CysteinesulfinateHypotaurine

Taurine

Molybdenum

CSD

GOT

NAD+ NADH

O2 CDSQR

SDO

ST

CBS

CSE

CBS

CSE (CTH)

HTDH

MolybdenumTST

SUOX

Cytochrome c

Serine

B6

B6

Glutathionereduced

+ ATPGS

GCL

GlutathioneOxidized

H2O

H2O2 NADP

NADPH

+

αKetoglutarate

Glutamate

ATP

NAD(P) +

NAD(P)HAmmonia

GDH

2 e-

Methionine

SAMe SAH HomocysteineMT

MAT

MS

SAHase

Pyruvate Acetyl-CoA

γ-Glu-Cys

ATPCoA-SH

Glycine5, 10-MTHF

5-MTHF

5-MTHF

BH2

BH4

BBB

BBB = Blood Brain BarrierETC = Electron Transport Chain

Glycine

SerineTHF

+5-HTP

Tyrosine

DOPA

NO

TPHPAHTH

NOSIron

B6B9

GPX1 GR

MTHFR

B9

+

B6

Serotonin/Melatonin Pathway

Red text indicates cofactors

Serotonin

N-acetylserotonin

Melatonin

Tryptophan

B3

B6, Vitamin C

SAMe

5-Hydroxytryptophan (5-HTP)

TryptamineKynurenine3-Hydroxy-kynurenine acid

Quinolinic acid

5-hydroxyindoleacetaldehyde

5-HIAA

Kynurenic acid Fe3+

O2- .

O2

BH4

Fe2+

qBH2

IDO

KMO

MAO

TYR Hydroxylase

AADC

KAT

SNAD

HIOMT

ALDH

TRPDC

Vitamin C

PEA, Dopamine, Norepinephrine, Epinephrine Pathway

L-DOPA

Dopamine

Norepinephrine

Epinephrine

L-PhenylalanineB6

B6

SAMe

L-Tyrosine

DOPACDOPAL

Phenylethylamine(PEA)

Tyramine

Fe3+

O2-.

Fe3+

O2-.

O2

BH4

Fe2+

Fe3+

OH- +HO.-H2O2

Fe2+

qBH2

O2

BH4

Fe2+ qBH2

MAO

PAH

TYR Hydroxylase

AADC

ALDH

PNMT

DBH

23 24

Vitamin D Pathway

Vitamin D3 (25(OH)D3)

CYP27B1 converts Vitamin D3(25(OH)D3) to active Vitamin D3 (1,25 (OH)2 D3). SNP is associated with a lower expression of the CYP27B1 enzyme, resulting in a diminished bioavailability of the enzyme.

GC gene (VDBP) transports active Vitamin D3 to Vitamin D3 Receptor (VDR).

SNP 1 and SNP 2 are associated with a reduced transport ability of active Vitamin D3 (1,225(OH)2 D3) to target cells. Both SNPs cover the African American and Caucasian populations.

VDR (Vitamin D3 Receptor) binds active Vitamin D3 (1,25(OH)2 D3) for bioavailability. SNP is associated with a lower binding capacity, resulting in lower bioavailability at target cells for metabolic processes.

Active Vitamin D3(1,25(OH)2 D3 VDR (Receptor)

Methylation Biochemistry

The nervous system is influenced by stressors, including those that trigger inflammation, an immune response, and oxidative stress. Pharmasan Labs offers immune profiles to identify immune stressors behind neurotransmitter imbalances.

A guide to interactions between the nervous and immune systems

This page summarizes many of the known interactions between the nervous and immune systems. Imbalances in these

neurotransmitters may indicate the need for immune assessment or root cause testing.

Inflammation Oxidative Stress

Immune Modulation

Immune Activation

Norepinephrine

Suppresses pro-inflammatory cytokines TNF-α, IL-1β, IFN-g Activates anti-inflammatory molecules (IκB) Binds to β–adrenoceptors on immune cells resulting in decreased

innate cell stimulation and pro-inflammatory cytokine release

Epinephrine

Decreases circulating monocytes B, T and NK cells Inhibits pro-inflammatory cytokines IL-1, IL-6, and TNF-α Binds to β–adrenoceptors on immune cells resulting in decreased

innate cell stimulation and pro-inflammatory cytokine release

Dopamine

Dopamine is synthesized in most immune cells Immune cells express dopamine receptors that play a role in

triggering or suppressing immune responses Binds to T cells and can activate the secretion of cytokines (Pro-

and anti-inflammatory)

Glutamate

Dendritic cells release glutamate upon maturation (post antigen binding)

Microglial cells release glutamate upon over-activation of the kynurenine pathway, causing an inflammatory response reaction

Histamine

Excesses or deficiencies can indicate immunological abnormalities

Production and release influenced by cytokines (IL-1, IL-3, IL-12, IL-18, TNF-α, etc.)

Serotonin Reduced levels can accompany chronic inflammation Pro-inflammatory cytokines cause shunting of tryptophan down

the kynurenine pathway, leading to reduced serotonin synthesis

GABA

The GABA signaling system can affect cytokine secretion, cell proliferation, phagocytic activity, and chemotaxis

Increased production of GABA can occur with activation of dendritic cells, macrophages, and T cells

Glycine Stimulates TNF-α release by macrophages Decreases TNF-α and IL-6 release from adipocytes Increased levels seen in neuro-inflammatory disorders

Sulfite

Key metabolite of hydrogen sulfide and a useful surrogate marker for assessing pathological conditions associated with an imbalance in hydrogen sulfide as well as conditions associated with an imbalance of sulfite itself.

Excessive sulfite disrupts normal immunological and neurological function leading to inflammation, oxidative stress, and excitotoxicity.

Excessive sulfite inhibits Glutamate dehydrogenase. Which increase levels of Glutamate in the system

Kynurenic Acid

Antioxidant, anti-inflammatory, and neuro-protective Broad-spectrum glutamate receptor antagonist; protecting

against excitotoxic effects of glutamate Suppresses release of presynaptic glutamate by inhibiting α7-

nicotinic acetylcholine receptors Kynurenic acid can also act as a scavenger of free radicals

Quinolinic Acid (coming soon)

Pro-inflammatory, and neuro-toxic Glutamate NMDA receptor agonist; potentiating the excitotoxic

effects of glutamate Inhibits glutamate uptake into astrocytes and stimulates

synaptosomal Glutamate release Destabilizes cytoskeleton of astrocytes and in-turn degrades the

protective qualities of the blood brain barrier Induces production of free radicals

NeuroInflammatory Interactions

Melatonin

Glycine

Taurine

Glutathione

5-MTHF

5-HTP

Tryptophan

L-DOPA

SAMe

SAMe

PhenylalanineTyrosine

Methionine Folate

SAMe

Cysteine

A

BH4

Homocysteine

Cystathione

BH2

MethylationPathways

SAH

MTHFRMSB12

B6

B6B6

B6

B6 B6

BHMT

DMG

TMG

5-HIAA

Melatonin

Serotonin

Kyn QNA

MAO

AADC

THIDO

Glycine

GlutamateSulfate

Hypotaurine

GlutamylcysteineTaurine

Glutathione

PNMT

Epinephrine

MAO Vit C

TH

AADC

Dopamine

DOPAC Norepinephrine

AADC

PH

PEA

AADC

TyramineSul�te

LEGEND

Blue text indicates reaction enzyme

Green text indicates enzyme cofactor

Dietary/supplemental pointsof intervention

A

A

A

ABBREVIATION KEY

5-HIAA: 5-Hydroxyindoleacetic acid

5-HTP: 5-Hydroxytryptophan

5-MTHF: 5-Methyltetrahydrofolate

AADC: Aromatic L-amino acid decarboxylase

BH2: Dihydrobiopterin

BH4: Tetrahydrobiopterin

BHMT: Betaine-homocysteine S-methyltransferase

DMG: Dimethylglycine

IDO: Indoleamine 2,3-dioxygenase

Kyn: Kynurenine

MAO: Monoamine oxidase

MTHFR: Methylenetetrahydrofolate reductase

MS: Methionine synthase

PH: Phenylalanine hydroxylase

PNMT: Phenylethanolamine N-methyltransferase

QNA: Quinolinic acid

SAH: S-adenosylhomocysteine

SAMe: S-adenosyl-L-methionine

TH: Tyrosine hydroxylase

TMG: Trimethylglycine

Methionine Cycle Folate Cycle Biopterin Cycle NT Metabolism

5-MTHF

5-HTP

Tryptophan

L-DOPA

SAMe

SAMe

PhenylalanineTyrosine

Methionine Folate

SAMe

Cysteine

Melatonin

Glycine

Taurine

Glutathione

5-MTHF

5-HTP

Tryptophan

L-DOPA

SAMe

SAMe

PhenylalanineTyrosine

Methionine Folate

SAMe

Cysteine

A

BH4

Homocysteine

Cystathione

BH2

MethylationPathways

SAH

MTHFRMSB12

B6

B6B6

B6

B6 B6

BHMT

DMG

TMG

5-HIAA

Melatonin

Serotonin

Kyn QNA

MAO

AADC

THIDO

Glycine

GlutamateSulfate

Hypotaurine

GlutamylcysteineTaurine

Glutathione

PNMT

Epinephrine

MAO Vit C

TH

AADC

Dopamine

DOPAC Norepinephrine

AADC

PH

PEA

AADC

TyramineSul�te

LEGEND

Blue text indicates reaction enzyme

Green text indicates enzyme cofactor

Dietary/supplemental pointsof intervention

A

A

A

ABBREVIATION KEY

5-HIAA: 5-Hydroxyindoleacetic acid

5-HTP: 5-Hydroxytryptophan

5-MTHF: 5-Methyltetrahydrofolate

AADC: Aromatic L-amino acid decarboxylase

BH2: Dihydrobiopterin

BH4: Tetrahydrobiopterin

BHMT: Betaine-homocysteine S-methyltransferase

DMG: Dimethylglycine

IDO: Indoleamine 2,3-dioxygenase

Kyn: Kynurenine

MAO: Monoamine oxidase

MTHFR: Methylenetetrahydrofolate reductase

MS: Methionine synthase

PH: Phenylalanine hydroxylase

PNMT: Phenylethanolamine N-methyltransferase

QNA: Quinolinic acid

SAH: S-adenosylhomocysteine

SAMe: S-adenosyl-L-methionine

TH: Tyrosine hydroxylase

TMG: Trimethylglycine

Methionine Cycle Folate Cycle Biopterin Cycle NT Metabolism

5-MTHF

5-HTP

Tryptophan

L-DOPA

SAMe

SAMe

PhenylalanineTyrosine

Methionine Folate

SAMe

Cysteine

25 26

Biomarker Specific Index

5-HIAA 9123.....................................9 9128 .................................. 10 91290 .................................6 9328 ................................. 10 9606 ................................. 10 9608 ................................. 10 9900 ..................................9

Borrelia 3002 ................................ 20 5200 ..................................17 5201 ...................................17 Candida 5116 ....................................15

Cortisol 7044 ...................................11 7070 ...................................11 7900 ...................................11 7950 ...................................11 9127 ................................... 10 91270 ..................................5

Celiac/Gluten 5056 ................................. 16

Cortisol x 4 7027....................................11 7071 ....................................11 7100 ....................................11 7127 .....................................11 7925 ....................................11 9028 ................................. 10 9128 .................................. 10 91280..................................6 9328 ................................. 10 9505 ................................. 10 9606 ................................. 10 9608 ................................. 10

Cytokine Analysis 5114 ....................................15 5115 .....................................15 5116 ....................................15 5306 ..................................15 5307 ..................................12 5316 ...................................12 5320 ................................... 7 5321 ..................................... 7

DHEA 5321 ..................................... 7 7027....................................11 7070 ...................................11 7071 ....................................11 7100 ....................................11 7127 .....................................11 7900 ...................................11 9028 ................................. 10 91280..................................6 9328 ................................. 10 9505 ................................. 10 9606 ................................. 10 9608 ................................. 10

DHEA-S 7044 ...................................11 7950 ...................................11

Dihydrotestosterone (DHT) 7950 ...................................11

DOPAC 5305 ..................................12 5306 ..................................12 5307 ..................................12 5320 ................................... 7 9099 ..................................15 9123.....................................9 9127 ................................... 10 9128 .................................. 10 91290 .................................6 9328 ................................. 10 9606 ................................. 10 9608 ................................. 10 9900 ..................................9

Dopamine 5320 ................................... 7 5321 ..................................... 7 9023 ...................................9 9028 ................................. 10 9074 ...................................9 9123.....................................9 9127 ................................... 10 91270 ..................................5 9128 .................................. 10 91280..................................6 91290 .................................6 9328 ................................. 10 9505 ................................. 10 9606 ................................. 10 9608 ................................. 10 9900 ..................................9

Epinephrine 9023 ...................................9 9028 ................................. 10 9074 ...................................9 9123.....................................9 9127 ................................... 10 91270 ..................................5 91271 ...................................5 9128 .................................. 10 91280..................................6 91281 ...................................6 91290 .................................6 91291 ...................................6 9328 ................................. 10 9505 ................................. 10 9606 ................................. 10 9608 ................................. 10 9900 ..................................9

Estradiol (E2) 5321 ..................................... 7 7027....................................11 7044 ...................................11 7070 ...................................11 7071 ....................................11 7100 ....................................11 7127 .....................................11 7900 ...................................11 9505 ................................. 10 9606 ................................. 10 9608 ................................. 10

Estriol (E3)

7127 .....................................11

7900 ...................................11

9606 ................................. 10

9608 ................................. 10

Estrone (E1)

5321 ..................................... 7

7027....................................11

7127 .....................................11

7900 ...................................11

9505 ................................. 10

9606 ................................. 10

9608 ................................. 10

Follicle-stimulating

Hormone (FSH)

7044 ...................................11

7950 ...................................11

GABA

5321 ..................................... 7

9023 ...................................9

9028 ................................. 10

9074 ...................................9

9123.....................................9

9127 ................................... 10

91270 ..................................5

9128 .................................. 10

91290 .................................6

9328 ................................. 10

9505 ................................. 10

9606 ................................. 10

9608 ................................. 10

9900 ..................................9

Glutamate

5305 ..................................12

5306 ..................................12

5307 ..................................12

9023 ...................................9

9028 ................................. 10

9074 ...................................9

9099 ..................................15

9123.....................................9

9127 ................................... 10

91270 ..................................5

91271 ...................................5

9128 .................................. 10

91280..................................6

91281 ...................................6

91290 .................................6

91291 ...................................6

9328 ................................. 10

9505 ................................. 10

9606 ................................. 10

9608 ................................. 10

9900 ..................................9

Glycine 5305 ..................................12 5306 ..................................12 5307 ..................................12 9023 ...................................9 9028 ................................. 10 9099 ..................................15 9123.....................................9 9127 ................................... 10 91270 ..................................5 91271 ...................................5 9128 .................................. 10 91280..................................6 91281 ...................................6 91290 .................................6 91291 ...................................6 9328 ................................. 10 9505 ................................. 10 9606 ................................. 10 9608 ................................. 10 9900 ..................................9

Histamine 9023 ...................................9 9028 ................................. 10 9123.....................................9 9127 ................................... 10 91270 ..................................5 9128 .................................. 10 9328 ................................. 10 9505 ................................. 10 9606 ................................. 10 9608 ................................. 10 9900 ..................................9

Kynurenic Acid 9099 ..................................15 91280..................................6 9900 ..................................9

Lipopolysacchorides (LPS) 5115 .....................................15

Luteinizing Hormone (LH) 7044 ...................................11 7950 ...................................11

Lymphocyte Analysis3013 .................................. 19

Melatonin 7127 .....................................11 7900 ...................................11 9127 ................................... 10 91270 ..................................5 9328 ................................. 10 9608 ................................. 10

Metals55600 .............................. 1655602 ............................... 1655605............................... 1655607 ............................... 1655612 ................................ 16

Natural Killer Cells (NK) 3014 .................................. 19 5067 ................................. 19

Norepinephrine 5305 ..................................12 5306 ..................................12 5307 ..................................12 5320 ................................... 7 5321 ..................................... 7 9023 ...................................9 9028 ................................. 10 9074 ...................................9 9123.....................................9 9127 ................................... 10 91270 ..................................5 91271 ...................................5 9128 .................................. 10 91280..................................6 91281 ...................................6 91290 .................................6 91291 ...................................6 9328 ................................. 10 9505 ................................. 10 9606 ................................. 10 9608 ................................. 10 9900 ..................................9

PEA 9023 ...................................9 9028 ................................. 10 9074 ...................................9 9123.....................................9 9127 ................................... 10 91270 ..................................5 91271 ...................................5 9128 .................................. 10 91280..................................6 91281 ...................................6 91291 ...................................6 9328 ................................. 10 9505 ................................. 10 9606 ................................. 10 9608 ................................. 10 9900 ..................................9

Progesterone 7027....................................11 7044 ...................................11 7070 ...................................11 7071 ....................................11 7100 ....................................11 7127 .....................................11 7900 ...................................11 7950 ...................................11 9505 ................................. 10 9606 ................................. 10 9608 ................................. 10

Serotonin 5305 ..................................12 5306 ..................................12 5307 ..................................12 5320 ................................... 7 5321 ..................................... 7 9023 ...................................9 9028 ................................. 10 9074 ...................................9 9123.....................................9

Serotonin 9127 ................................... 10

91270 ..................................5

91271 ...................................5 9128 .................................. 10

91280..................................6

91281 ...................................6

91290 .................................6

91291 ...................................6

9328 ................................. 10

9505 ................................. 10

9606 ................................. 10

9608 ................................. 10

9900 ..................................9

Sex-hormone Binding Globulin (SHBG) 5320 ................................... 7

7044 ...................................11 7950 ...................................11

Sulfite

9099 ..................................15

91280..................................6

91290 .................................6

91291 ...................................6

9900 ..................................9

Taurine

5305 ..................................12

5306 ..................................12

5307 ..................................12

5320 ................................... 7

5321 ..................................... 7

9123.....................................9

91270 ..................................5

9128 .................................. 10

91280..................................6

9328 ................................. 10

9606 ................................. 10

9608 ................................. 10

9900 ..................................9

Testosterone

5320 ................................... 7

7027....................................11

7070 ...................................11

7071 ....................................11

7100 ....................................11

7127 .....................................11

7900 ...................................11

7925 ....................................11

7950 ...................................11

9505 ................................. 10

9606 ................................. 10

9608 ................................. 10

Thyroid 7022 ...................................11 7023 ...................................11 7024 ...................................11 7025 ...................................11

7950 ...................................11

Profile # ............ Page #

Pharmasan Labs™ Contact Information

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Contact Customer Service at 888-342-7272, or

visit the website to confirm availability.

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Specimen Requirement TypeUrine = Urine Specimen

Saliva Tube = Saliva Specimen

Saliva Disc = Saliva Specimen

Yellow Top = Whole Blood Specimen

Lavender Top = Whole Blood Specimen

Tiger Top = Serum Specimen

Child Collection Materials Availablefor the following profiles: 9074 Neuro Essential,

9023 NeuroScreen Basic, 9123 NeuroScreen Expanded.

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General Information

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Date: ______________________________ Ship to: Patient Healthcare Practitioner Account # _____________________

Healthcare Practitioner/Business Name____________________________________________ Diagnostic Code: _____________________ (include when drop-shipping to patient)

Patient’s Name (if shipping to patient): ________________________________________________________________________________

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Note: To prevent confusion, this profile should not be drop-shipped.

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Comments and/or questions:

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Choose 1 profile to run. The list of profiles available is located on page 2 of the requisition form.

Add the correct collection form.Each profile order that includes a 9950 will receive one of each instruction (5). Health care providers can make copies of these instructions or download additional instructions from the NeuroScience website under [Testing] as needed.

Remove any excess tubes.Each 9950 kit includes the same amount of urine (2) and saliva (4) tubes. Depending on the profile ordered, some tubes may not be required and should be removed to prevent confusion.

Example: Instruction A only requires 2 urine tubes. Remove all 4 saliva tubes.

Urine Tubes Saliva Tubes

9950 Multi-option Profile

15 reasons to order the 9950The 9950 is a multi-option profile featuring 15 of Pharmasan Labs™ most popular neurotransmitter and hormone profiles in a single collection box.

The 9950 in 3 easy steps.

1 2

3

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The CAP Surveys and Anatomic Pathology Education/EXCEL Programs are the largest laboratory peer comparison programs in the world. These programs allow laboratories to regularly evaluate their performance and improve the accuracy of the patient results they provide. Through laboratory proficiency programs, individual laboratories are provided with unknown specimens for testing. The participants analyze the specimens and return the results for evaluation. Lab test results are evaluated using comparable peer groups from the most comprehensive databases of laboratories. Labs are compared to the most relevant instrument/reagent combinations to accurately assess their performance. In turn, each participating laboratory receives a report of their performance as well as a report summarizing the results of all participating laboratories. This information can be used to improve performance in order to provide the best patient care.

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