PROGRAMME - jmmc2017.hr · PROGRAMME. ORGANISER Section of Medicinal/Pharmaceutical Chemistry of...

PROGRAMME

O RG A N I S E R

Sect ion of Medicinal/Pharmaceut ical Chemist ry of the Croat ian Chemical Society

Zagreb, Croat ia

P A R T N E R I N O R G A N I S A T I O N

Tip putovanja – turisti~ka agencija d.o.o.

S I L VE R PA R TN E R

S U PP O R T ED B Y

S P O N S O R S

S P O N S O R S

M ED I A P A R TN E RS

The 10 th Joint Meeting on Medicina l Chemistry

June 25–28, 2017, Dubrovnik (Srebreno), Croat ia 7

Dear Participants,

The 10th JMMC follows the tradition created by several European national medicinal chemistry societies to organize these joint scientific events in the years between the biennial International Symposia on Medicinal Chemistry (EFMC/ISMC). Various European cities have hosted the JMMC since the first one 1999 in Taormina: Budapest (2001 and 2009), Krakow (2003), Vienna (2005), Portorož (2007), Catania (2011), Lublin (2013) and the most recent one in Athens (2015). The JMMCs is an important scientific event in the field of medicinal chemistry which gives the opportunity for networking of the participants coming mainly from the nine middle European countries: Austria, Croatia, Czech Republic, Greece, Hungary, Italy, Poland, Slovakia and Slovenia. This leads us to the principal aims of the Meeting: dissemination of research results, training of young researchers and enhancement of transnational collaborations between scientists from academia as well as industry.

The 10th JMMC will continue the tradition and will cover drug discovery advances in the major therapeutic areas, including anti-infectives, neurodegenerative diseases and oncology. JMMC 2017 will present various topics which will cover advances in approaches for hit findings and accelerating lead optimization process, exploration of new chemical entities from nature, discovery of small molecule chemical probes, optimization of drug delivery and computational medicinal chemistry. Our intention is to get together scientists from different countries, disciplines and sectors, and in a relaxed atmosphere discuss and rationalize results and challenges associated with new drug discovery. As you know, Dubrovnik is one of the most visited spots on the Croatian coastline, where Mediterranean grace, rich history and culture fusion in a unique beauty and harmony.

Looking forward to seeing You in Dubrovnik, the Pearl of the Adriatic!

Vesna Gabelica Marković Head of the Section of Medicinal/Pharmaceutical Chemistry

of the Croatian Chemical Society



N A T I O N A L O R G A N I Z I N G C O MMI T T E E

Vesna Gabelica Marković (Chair) Croatian Chemical Society, Zagreb

Nikola Basarić Ruđer Bošković Institute, Zagreb

Ivanka Jerić Ruđer Bošković Institute, Zagreb

Sanja Koštrun Fidelta Ltd., Zagreb

Danijel Namjesnik Faculty of Science, University of Zagreb

Ivana Perković Faculty of Pharmacy and Biochemistry, University of Zagreb

Silvana Raić-Malić Faculty of Chemical Engineering and Technology, University of Zagreb

Rosana Ribić Faculty of Science, University of Zagreb

Višnja Stepanić Ruđer Bošković Institute, Zagreb

Ines Vujasinović Fidelta Ltd., Zagreb


10 June 25–28, 2017, Dubrovnik (Srebreno), Croat ia

I N TERNA T I ONA L O RGA NIZ I NG CO MMI T TEE

Schnürch Michael Vienna University of Technology, Vienna, Austria

Vesna Gabelica Marković Croatian Chemical Society, Zagreb, Croatia

Jarmila Vinšová Charles University in Prague, Prague, Czech Republic

Emmanuel Mikros National and Kapodistrian University of Athens, Athens, Greece

János Wölfling University of Szeged, Szeged, Hungary

Girolamo Cirrincione University of Palermo, Palermo, Italy

Katarzyna Kieć-Kononowicz Jagiellonian University Medical College, Kraków, Poland

Andrej Boháč Comenius University in Bratislava, Bratislava, Slovakia

Marko Anderluh University of Ljubljana, Ljubljana, Slovenia



I N T E RN A T I O N A L SC I EN T I F I C C O M MI T TE E

Marko Mihovilovic Vienna University of Technology, Vienna, Austria

Višnja Stepanić Ruđer Bošković Institute, Zagreb, Croatia

Jarmila Vinšová Charles University in Prague, Prague, Czech Republic

Anna Tsantili National and Kapodistrian University of Athens, Athens, Greece

Péter Mátyus Semmelweis University, Budapest, Hungary

Gabriele Constantino University of Parma, Parma, Italy

Dariusz Matosiuk Medical University of Lublin, Poland

Milan Remko Comenius University in Bratislava, Bratislava, Slovakia

Danijel Kikelj University of Ljubljana, Ljubljana, Slovenia



P L EN A RY L EC TU R E RS

Nenad Ban (ETH Zürich, CH) Beyond the Prokaryotic Ribosome: Structural and Functional Insights Into Eukaryotic and Mitochondrial Ribosomes

Gerhard Klebe (University of Marburg, DE) What Thermodynamics Can Help to Understand Protein-Ligand Binding in Medicinal Chemistry

Paul Brennan (University of Oxford, UK) Chemical Probes in Target Discovery

Margot Ernst (Medical University Vienna, AT) GABAA Receptor Subtypes: A Structure Guided Path to Selective Compounds

Ivo Piantanida (Ruđer Bošković Institute, HR) Design of Small Molecular Probes for Proteins and DNA / RNA

Martin Krátký (Charles University, CZ) Oligotuftsin-based Carriers for Novel Antimycobacterial Active Agents and Their Conjugates



Grigoris Zoidis (National and Kapodistrian University of Athens, GR) Metal Chelating Agents Against Viruses and Parasites

János Wölfling (University of Szeged, HU) Old Scaffolds in New Role: Steroids as Antiproliferative Agents

Girolamo Cirrincione (University of Palermo, IT) Marine Environment Inspires Kinases Inhibitors

Jadwiga Turlo (Medical University of Warsaw, PL) Polysaccharides as Biological Response Modifiers: Structure-Activity Relationship

Stanislav Gobec (University of Ljubljana, SI) New Hits and Leads for Neurodegenerative Disorders



K E YN O T E L E C T UR E RS

Hannes Mikula (Technical University Vienna, AT) Pretargeted Prodrug Activation Through Bioorthogonal Elimination

Vesna Eraković Haber (Fidelta Ltd., HR) Patient Derived Testing Systems – Reaching Beyond Targed Based Drug Discovery

Robert Vianello (Ruđer Bošković Institute, HR) Computational Insight into the Catalytic Activity of Monoamine Oxidase Enzyme for Targeting Neurological Diseases

Marta Kučerová-Chlupáčová (Charles University, CZ) Antimicrobial Potential of 1,2,4-Oxadiazoles and Their Synthesis

Radim Nencka (Czech Academy of Sciences, CZ) Rational Design of PI4KB Inhibitors as Potential Broad-spectrum Antiviral Agents

Aligiannis Nektarios (National and Kapodistrian University of Athens, GR) Can Multivariate Statistics Aid to the Reveal of Bioactive Compounds? An NMR and HPTLC Approach

Vasiliki Sarli (Aristotle University of Thessaloniki, GR) New Drug Conjugates Based on Azasteroids or Peptides for Targeted Drug Delivery in Cancer Therapy

Marco Macchia (University of Pisa, IT) Endocannabinoid System Modulation: Therapeutic Implications and Future Perspectives



Gianluca Sbardella (University of Salerno, IT) A "Library-on-Library" Screening Approach to Identify Small-Molecule Ligands of Methyl-Lysine Reader Proteins

Krzysztof Kaminski (Jagiellonian University, PL) Hybrid Compounds in the Search for the New Highly Effective Anticonvulsants

Maciej Dawidowski (Medical University of Warsaw, PL) Disrupting the PEX14-PEX5 Interaction by Small Molecules Provides a Novel Strategy for Treatment of Trypanosoma Infections

Magdaléna Májeková (Slovak Academy of Sciences, SK) Ligand-based Drug Design of Novel Aldose Reductase Inhibitors from Databases of Indole-1-Acetic Acids

Pavol Jakubec (Slovak University of Technology, SK; Harward University, USA) A Platform for the Discovery of New Macrolide Antibiotics

Matej Sova (University of Ljubljana, SI) Design and Synthesis of Novel Modulators of Toll-like Receptors and Inhibitors of Indoleamine 2,3-Dioxygenase (IDO1)

Nace Zidar (University of Ljubljana, SI) Discovery of N-phenylpyrrolamides as ATPase Inhibitors of DNA Gyrase and Topoisomerase IV

SUNDAY, JUNE 25 14:00-17:00 Registration

17:00-17:30 Opening of the Meeting

A WAY FORWARD TO NEW ANTI-INFECTIVES Moderator: Gabriele Constantino (Italy)

17:30-18:15 PL-1 Nenad Ban (ETH Zürich, CH) Beyond the Prokaryotic Ribosome: Structural and Functional Insights Into Eukaryotic and Mitochondrial Ribosomes

18:15-18:45 KL-1 Pavol Jakubec (Slovak University of Technology, SK; Harward University, USA) A Platform for the Discovery of New Macrolide Antibiotics

18:45-19:25 PL-2 Martin Krátký (Charles University, CZ) Oligotuftsin-based Carriers for Novel Antimycobacterial Active Agents and Their Conjugates

19:30 Welcome party

MONDAY, JUNE 26

RATIONAL APPROACH TO THE DESIGN OF NOVEL DRUGS Moderator: Margot Ernst (Austria)

9:00-9:45 PL-3 Gerhard Klebe (University of Marburg, DE) What Thermodynamics Can Help to Understand Protein-Ligand Binding in Medicinal Chemistry

9:45-10:15 KL-2 Nace Zidar (University of Ljubljana, SI) Discovery of N-phenylpyrrolamides as ATPase Inhibitors of DNA Gyrase and Topoisomerase IV

10:15-10:45 Coffee break

ANTI-INFECTIVE CASE STUDIES Moderator: Marko Anderluh (Slovenia)

10:45-11:25 PL-4 Grigoris Zoidis (National and Kapodistrian University of Athens, GR) Metal Chelating Agents Against Viruses and Parasites

11:25-11:55 KL-3 Marta Kučerová-Chlupáčová (Charles University, CZ) Antimicrobial Potential of 1,2,4-Oxadiazoles and Their Synthesis

11:55-12:25 KL-4 Radim Nencka (Czech Academy of Sciences, CZ) Rational Design of PI4KB Inhibitors as Potential Broad-spectrum Antiviral Agents

12:25-15:00 Lunch – POSTER SESSION I

FILLING THE GAP IN THE DISCOVERY OF NEW ANTI-CANCER DRUGS Moderator: Ivo Piantanida (Croatia)

15:00-15:40 PL-5 Girolamo Cirrincione (University of Palermo, IT) Marine Environment Inspires Kinases Inhibitors

15:40-16:10 KL-5 Matej Sova (University of Ljubljana, SI) Design and Synthesis of Novel Modulators of Toll-like Receptors and Inhibitors of Indoleamine 2,3-Dioxygenase (IDO1)


16:30-17:10 PL-6 János Wölfling (University of Szeged, HU) Old Scaffolds in New Role: Steroids as Antiproliferative Agents

17:10-17:40 KL-6 Vasiliki Sarli (Aristotle University of Thessaloniki, GR) New Drug Conjugates Based on Azasteroids or Peptides for Targeted Drug Delivery in Cancer Therapy

18:30 Trip to Dubrovnik

TUESDAY, JUNE 27 LOOKING AT THE EPIGENETIC LEVEL

Moderator: János Wölfling (Hungary)

9:00-9:45 PL-7 Paul Brennan (University of Oxford, UK) Chemical Probes in Target Discovery

9:45-10:15 KL-7 Gianluca Sbardella (University of Salerno, IT) A "Library-on-Library" Screening Approach to Identify Small-Molecule Ligands of Methyl-Lysine Reader Proteins


IN SEARCH FOR NOVEL BIOLOGICALLY ACTIVE MOLECULES Moderator: Jadwiga Turlo (Poland)

10:35-11:15 PL-8 Margot Ernst (Medical University Vienna, AT) GABAA Receptor Subtypes: A Structure Guided Path to Selective Compounds

11:15-11:45 KL-8 Maciej Dawidowski (Medical University of Warsaw, PL) Disrupting the PEX14-PEX5 Interaction by Small Molecules Provides a Novel Strategy for Treatment of Trypanosoma Infections

11:45-12:15 KL-9 Krzysztof Kaminski (Jagiellonian University, PL) Hybrid Compounds in the Search for the New Highly Effective Anticonvulsants

12:15-12:45 KL-10 Aligiannis Nektarios (National and Kapodistrian University of Athens, GR) Can Multivariate Statistics Aid to the Reveal of Bioactive Compounds? An NMR and HPTLC Approach

12:45-14:00 Lunch

TARGETING NEURODEGENERATIVE DISORDERS Moderator: Vesna Eraković Haber (Croatia)

14:00-14:40 PL-9 Stanislav Gobec (University of Ljubljana, SI) New Hits and Leads for Neurodegenerative Disorders

14:40-15:10 KL-11 Marco Macchia (University of Pisa, IT) Endocannabinoid System Modulation: Therapeutic Implications and Future Perspectives

15:10-15:40 KL-12 Robert Vianello (Ruđer Bošković Institute, HR) Computational Insight into the Catalytic Activity of Monoamine Oxidase Enzyme for Targeting Neurological Diseases

15:40-17:00 Coffee break – POSTER SESSION II

ORAL PRESENTATIONS – section I Moderator: Magdaléna Májeková (Slovak Republic)

17:00-17:15 OP-1 Manabu Kawada (Institute of Microbial Chemistry - BIKAKEN, JP) Anti-Helicobacter Pylori Activity of a Novel Derivative of Intervenolin

17:15-17:30 OP-2 Nela Malatesti (University of Rijeka, HR) In vitro Photodynamic Activity of a New Tri-Cationic Amphiphilic Porphyrin Against Herpes Simplex Virus 1, Bacteria And Cancer Cells

17:30-17:45 OP-3 Giannamaria Annunziato (University of Parma, IT) Discovery of New, Potential Anti-Infective Compounds Based on Carbonic Anhydrase Inhibitors by Rational Target-Focus Repurposing Approach

17:45-18:00 OP-4 Michaela Barančoková (University of Ljubljana, SI) Discovery of Novel Gyrase B Inhibitors and Gyrase B/Topoisomerase IV (ParE) Dual Inhibitors with In Vitro Antibacterial Activity

18:00-18:15 OP-5 Tommaso Felicetti (University of Perugia, IT) Fighting Antimicrobial Resistance by Breaking Resistance Mechanisms

18:15-18:30 OP-6 Dmitry Tsvelikhovsky (The Hebrew University of Jerusalem, IL) α-Enaminones: New Building Blocks for Direct Synthesis of Biologically Active Alkaloids

18:30-18:45 OP-7 Marcin J. Cieślak (Polish Academy of Sciences, PL) Novel Benzo[b]furan Derivatives – Biological Activity and Protein Target Identification in Leukemic Cells

18:45-19:00 OP-8 Moran Shubely (Bar-Ilan University, IL) Development of Novel Drug Candidate Against Prostate Cancer

ORAL PRESENTATIONS – section II Moderator: Jarmila Vinšová (Czech Republic)

17:00-17:15 OP-9 Rafał Kurczab (Polish Academy of Sciences, PL) Evaluation of Halogen Bonding Hot Spots by Virtual Screening of Commercial Databases – a Case Study of 5-HT7R

17:15-17:30 OP-10 Jaroslaw Polanski (University of Silesia, PL) Big Data: Avogadro Stoichiometry Explains Hyperbolic Ligand Efficiency Trend

17:30-17:45 OP-11 Vassilios Myrianthopoulos (University of Athens, GR) From Public Domain Compound Collections to Cell-Active Epigenetic Modulators. The Case of the NCI Repository

17:45-18:00 OP-12 Thavendran Govender (University of KwaZulu Natal, ZA) Mass Spectrometric Imaging as a Preclinical Tool for Medicinal Chemists

18:00-18:15 OP-13 David Chan Bodin Siebert (Technical University Vienna, AT) Pyrazoloquinolinones, Revisited GABAA Receptor Tool Compounds

18:15-18:30 OP-14 Svetlana Maklakova (Lomonosov Moscow State University, RU) Synthesis of Tissue-Specific Conjugates for Targeted Drug Delivery Into Hepatic Cells

18:30-18:45 OP-15 Rosana Leiva (Universitat de Barcelona, ES) Novel Polycyclic N-acylpyrrolidines as 11β-HSD1 Inhibitors

18:45-19:00 OP-16 Maria Majellaro (University of Santiago de Compostela, ES) Enantiospecific Modulation Of A2B Adenosine Receptor

20:00 Gala Dinner

WEDNESDAY, JUNE 28

LIGAND-BASED APPROACH Moderator: Gianluca Sbardella (Italy)

9:00-9:40 PL-10 Jadwiga Turlo (Medical University of Warsaw, PL) Polysaccharides as Biological Response Modifiers: Structure-Activity Relationship

9:40-10:10 KL-13 Magdaléna Májeková (Slovak Academy of Sciences, SK) Ligand-based Drug Design of Novel Aldose Reductase Inhibitors from Databases of Indole-1-Acetic Acids

10:10-10:40 KL-14 Hannes Mikula (Technical University Vienna, AT) Pretargeted Prodrug Activation Through Bioorthogonal Elimination


FROM MOLECULAR PROBES TO CLINICS Moderator: Hannes Mikula (Austria)

11:00-11:40 PL-11 Ivo Piantanida (Ruđer Bošković Institute, HR) Design of Small Molecular Probes for Proteins and DNA / RNA

11:40-12:10 KL-15 Vesna Eraković Haber (Fidelta Ltd., HR) Patient Derived Testing Systems – Reaching Beyond Targed Based Drug Discovery

12:15-12:45 WINNING POSTERS FLASH PRESENTATIONS

12:45-13:00 CLOSING



P O ST E R P R ES EN TA T I O N S

P-1 FREE RADICAL SCAVENGING POTENCY OF DIHYDROCAFFEIC ACID: THERMODYNAMICS OF 2H+/2e–

PROCESSES Ana Amić, Zoran Marković, Jasmina Dimitrić Marković, Bono Lučić and Dragan Amić

P-2 RADICAL SCAVENGING AND COX-2 INHIBITION BY COLON METABOLITES OF POLYPHENOLS: A THEORETICAL APPROACH Ana Amić, Zoran Marković, Jasmina M. Dimitrić Marković, Svetlana Jeremić, Bono Lučić and Dragan Amić

P-3 CYTOTOXICITY OF A KOJIC ACID DERIVATIVE ON A375 HUMAN MALIGNANT MELANOMA AND HGF1 FIBROBLAST CELLS M. D. Aytemir, G. Karakaya, A. Ercan and S. Öncül

P-4 DESIGN AND SYNTHESIS OF NOVEL TARGETED CHEMICAL CHAPERONES AS A BASIS FOR AMYOTROPHIC LATERAL SCLEROSIS (ALS) TREATMENT Salome Azoulay-Ginsburg, Tamar Getter, Edward Korshin and Arie Gruzman

P-5 MULTICOMPONENT SYNTHESIS OF NOVEL ANDROSTANO-PYRIMIDINES AND THEIR PHARMACOLOGICAL EVALUATION IN VITRO Ádám Baji, Éva Frank and Mónika Kiricsi

P-6 A COMPARATIVE MOLECULAR MODELLING STUDY OF MAO-A, MAO-B AND SSAO INHIBITORS Balázs Balogh, Michela Contu, Elias Maccioni and Péter Mátyus

P-7 IDENTIFICATION OF NEW KDM4 INHIBITORS THROUGH A HTS AND HIT REFINEMENT STRATEGY A. L. Balzano, F. Sarno, C. Milite, G. Franci, I. Forné, L. Altucci, A. Ihmof, S. Castellano and G. Sbardella

P-8 SYNTHESIS AND ANTIOXIDATIVE ACTIVITY OF SOME QUATERNARY 3-HYDROXYQUINUCLIDINIUM SALTS DETERMINED BY DPPH METHOD Linda Bazina, Matilda Šprung, Barbara Soldo and Renata Odžak

P-9 PHYTOCHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITY OF THE EXTRACTS OF SATUREJA SUBSPICATA VIS. GROWING IN BOSNIA AND HERZEGOVINA Mejra Bektašević, Ivana Carev, Marin Roje, Mladenka Jurin and Olivera Politeo

P-10 NOVEL ANTICANCER DRUGS DISPIRO-OXINDOLE SERIES BASED ON VARIOUS TYPES OF HETEROCYCLES: SYNTHESIS AND BIOLOGICAL TESTING A. A. Beloglazkina, A. A.Barashkin, G. A. Kotovskii, M. A. Kunin, N. A. Karpov, M. E. Kukushkin, E. K. Beloglazkina, N. V. Zyk D. A. Skvortsov, N. A. Vorobyeva and A. G. Majouga

P-11 OSTEOBLASTIC CELL BEHAVIOUR ON DIFFERENT TITANIUM - SURFACE ANALYSIS M. Lukaszewska-Kuska, R. Majchrowski and B. Dorocka-Bockowska

P-12 A NOVEL CLASS OF HIGHLY POTENT SMALL MOLECULE INHIBITORS OF RHINOVIRUS REPLICATION: 6-{[2-(METHYLCARBAMOYL)PYRIDIN-4-YL]OXY}BENZO[B]THIOPHENE-2-CARBOXYLIC ESTER DERIVATIVES S. B. Han, J. W. Kim, U.-K. Jung, J. Y. Lee, C. Kim and Y.-S. Jung

P-13 SYNTHESIS, DOCKING AND ANTI-CANDIDA ACTIVITY OF SOME NEW 1,4-PHENYLENE-BISTHIAZOLES AS INHIBITORS OF LANOSTEROL 14α-DEMETHYLASE Anca-Maria Borcea, Ilioara Oniga, Gabriel Marc, Dan C Vodnar, Adrian Pîrnău, Laurian Vlase, Andreea Pricopie, Brînduşa Tiperciuc and Ovidiu Oniga

P-14 SCREENING OF BIOLOGICAL ACTIVITY OF CENTAUREA SPECIES AQUEOUS EXTRACTS Ivana Carev, Anja Golemac, Sanda Raić, Jelena Žarković, Ana Kelavić, Maria Šarić, François-Xavier Pellay and Olivera Politeo



P-15 ANTIOXIDANT ACTIVITY AND LIPOPHILICITY EVALUATION OF SOME NEW THIAZOLYL-TRIAZOLE SCHIFF BASES Cezar Login, Daniela Benedec, Ioana Ionuţ, Cristina Nastasă, Anca Stana, Ovidiu Oniga and Brîndușa Tiperciuc

P-16 NOVEL 2,4-DIAMINOPYRIMIDINE BEARING FUSED TRICYCLIC RING MOIETY FOR ANAPLASTIC LYMPHOMA KINASE (ALK) INHIBITOR Chang-Soo Yun, Chong Ock Lee, Hyoung Rae Kim, Chi Hoon Park, Pilho Kim and Jong Yeon Hwang

P-17 TARGETED DELIVERY OF CYTOTOXIC AGENTS VIA cRGD PEPTIDE IN CANCER THERAPY AND THERANOSTICS Theodora Chatzisideri, Savvas Thysiadis, Sotirios Katsamakas, Theodore Lazarides and Vasiliki Sarli

P-18 METHODS OF SYNTHESIS OF BIOLOGICALLY ACTIVE ANALOGUES AND HOMOLOGUES AMINOPHOSPHONATES AND AMINOBISHOSPHONATES Ewa Chmielewska, Joanna Wietrzyk and Paweł Kafarski

P-19 MOLECULAR MODELING AND DYNAMICS STUDIES OF LIGAND-DEPENDENT CONFORMATIONAL MACROSTATES OF A2A ADENOSINE RECEPTOR Yoonji Lee, Changbong Hyeon and Sun Choi

P-20 NEW DICARBOXIMIDE DERIVATIVES – ANTICANCER ACTIVITY AND MECHANISM OF ACTION Julia Kaźmierczak-Barańska, Karolina Królewska, Marcin J Cieślak, Milena Sobczak, Bożena Kuran, Mariola Napiórkowska, Jerzy Kossakowski and Barbara Nawrot

P-21 ANTIPROLIFERATIVE ACTIVITY OF QUINONE METHIDES WITH BODIPY CHROMOPHORE Matej Cindrić, Nikola Basarić, Irena Martin Kleiner, Lidija Uzelac and Marijeta Kralj

P-22 MEPHEDRONE METABOLITES AND DERIVATIVES Daniela Cintulova, Laurin Wimmer, Harald H. Sitte and Marko D. Mihovilovic

P-23 NOVEL SOLUBLE EPOXIDE HYDROLASE INHIBITORS FEATURING A 2-OXAADAMANTANE MOIETY I: PIPERIDINE DERIVATIVES Sandra Codony, Javier Pizarro, Elena Valverde, Eugènia Pujol, M. Isabel Loza, J. Manuel Brea, Elena Saez, Julen Oyarzábal, Belén Pérez, Rosana Leiva, Manuel Vázquez-Carrera and Santiago Vázquez

P-24 NOVEL SOLUBLE EPOXIDE HYDROLASE INHIBITORS FEATURING A 2-OXAADAMANTANE MOIETY II: AROMATIC DERIVATIVES Eugènia Pujol, Javier Pizarro, Elena Valverde, Sandra Codony, Tiziana Ginex, M. Isabel Loza, J. Manuel Brea, Belén Pérez, Elena Sáez, Julen Oyarzabal, F. Javier Luque, Rosana Leiva, Manuel Vázquez-Carrera, Santiago Vázquez

P-25 BIOLOGICAL ACTIVITIES OF EXTRACTS FROM THYME (THYMUS VULGARIS) LEAVES Biljana Damjanović-Vratnica, Slađana Krivokapić, Snežana Pantović and Svetlana Perović

P-26 SYNTHESIS, ANTICANCER ACTIVITY AND DOCKING STUDIES OF NEW PHENYLAMINOPYRIMIDINE DERIVATIVES Aslı Demirci, İrem Durmaz, Rengül Çetin Atalay, and İlkay Küçükgüzel

P-27 RADIOLABELED 1,2,4,5-TETRAZINES AS BIOORTHOGONAL IMAGING TOOLS Christoph Denk, Martin Wilkovitsch, Thomas Wanek, Claudia Kuntner Hannes, Dennis Svatunek and Hannes Mikula

P-28 IDENTIFICATION OF EXPANDED CAG REPEATS LIGANDS TO COUNTERACT HUNTINGTON’S DISEASE Jenny Desantis, Kenji Schorp, Serena Massari, Anna Bochicchio, Frank Matthes, Judith Schilling, Stephanie Weber, Nina Offermann, Paolo Carloni, Kamyar Hadian, Giulia Rossetti, Oriana Tabarrini and Sybille Krauss



P-29 SYNTHESIS OF SOME NEW BENZOTHIAZOLONE DERIVATIVES AND INVESTIGATION OF THEIR CHOLINESTERASE INHIBITOR ACTIVITIES Deniz S. Dogruer, Merve Erdogan and Burcu Kilic

P-30 LONG-CHAIN DERIVATIVES OF (TRIFLUOROMETHYLPHENYL)PIPERAZINES – SYNTHESIS AND EVALUATION OF THE ACTIVITY TOWARDS 5-HT RECEPTORS Anna Drabczyk, Jolanta Jaśkowska, Damian Kułaga, Grzegorz Satała and Magdalena Malinowska

P-31 SYNTHESIS AND EVALUATION OF THE ACTIVITY TOWARDS 5-HT RECEPTORS OF NEW LIGANDS FROM THE LCAPS GROUP Anna Drabczyk, Jolanta Jaśkowska, Damian Kułaga, Grzegorz Satała and Magdalena Malinowska

P-32 SYNTHESIS OF PHOTOSWITCHABLE INHIBITORS FOR CNS APPLICATIONS D. Dreier, M. Holy, K. Jäntsch, H. H. Sitte and M. D. Mihovilovic

P-33 AER METHOD: A GOOD WAY TO OBTAIN APIs AS IONIC LIQUIDS E. Alcalde, I. Fallon, F. Roig, J. Esquena, M. J. García-Celma and I. Dinarès

P-34 SYNTHESIS OF SOME NEW BENZOXAZOLONE DERIVATIVES AND EVALUATION OF THEIR CHOLINESTERASE INHIBITOR ACTIVITIES Merve Erdoğan, Burcu Kılıç and Deniz S. Doğruer

P-35 DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW SERIES OF DIHYDROXYLATED 2,6-DIPHENYL-4-CHLOROPHENYLPYRIDINES: DNA NON-INTERCALATIVE CATALYTIC TOPOISOMERASE I & IIα DUAL INHIBITOR Eung-Seok Lee, Ganesh Bist, Til Bahadur Thapa Magar, Aarajana Shrestha, Pramila Katila and Youngjoo Kwon

P-36 SYNTHESIS OF RING A-FUSED PYRAZOLE REGIOISOMERS IN THE ANDROSTANE SERIES AND AN EVALUATION OF THEIR CELL-GROWTH INHIBITORY EFFECTS IN VITRO Éva Frank, Ádám Baji, Gergő Mótyán and István Zupkó

P-37 SYNTHESIS, CYTOSTATIC AND ANTIBACTERIAL EVALUATIONS OF N-4-BENZOYLCYTOSINE–1,2,3-TRIAZOLE AND 7-DEAZAPURINE–1,2,3-TRIAZOLE HYBRIDES Maja Stipković Babić, Mande Miošić, Moris Mihovilović, Marijana Jukić, Ljubica Glavaš-Obrovac, Domagoj Drenjančević, Silvana Raić-Malić and Tatjana Gazivoda Kraljević

P-38 STERANE-FUSED PYRAZOLES: AN EFFICIENT MICROWAVE-ASSISTED SYTHESIS ON RING A Gergő Mótyán, Réka Kiss-Faludy, János Wölfilng and Éva Frank

P-39 BROADLY EFFECTIVE METAL CHELATORS, AS INFLUENZA PA ENDONUCLEASE AND HEPATITIS C VIRUS INHIBITORS Erofili Giannakopoulou, Annelies Stevaert, Efseveia Frakolaki, Vassilios Myrianthopoulos, Emmanuel Mikros, Ralf Bartenschlager, Niki Vassilaki, Lieve Naesens and Grigoris Zoidis

P-40 ORGANOCATALYSIS MEETS BETA LACTAMS Thavendran Govender, Tricia Naicker, Hendrik G. Kruger and Per I. Arvidsson

P-41 SEARCH FOR 5-HT6 RECEPTOR AGENTS AMONG TRIAZINE DERIVATIVES OF HYDANTOIN Jadwiga Handzlik, Rafał Kurczab, Dorota Łażewska, Małgorzata Więcek, Angelika Nowakowska, Grzegorz Satała, Andrzej J. Bojarski and Katarzyna Kieć-Kononowicz

P-42 NOVEL SYNTHESIS OF (+)-DIENOMYCIN C AND ANALOGOUS COMPOUNDS WITH ANTIBACTERIAL ACTIVITY Hajime Yokoyama, Yuko Hayashi, Hiromi Ejiri, Masahiro Miyazawa and Yoshiro Hirai

P-43 NOVEL para SUBSTITUTED N-ARYL 3-HYDROXYPYRIDIN-4-ONE MANNOSIDES: SYNTHESIS, HEMAGGLUTINATION INHIBITORY PROPERTIES AND MOLECULAR MODELING V. Petrović Peroković, Ž. Car, K. Meglić, R. Ribić, T. Tandarić, R. Vianello and S. Tomić



P-44 ANTIBACTERIAL AND ANTIPROLIFERATIVE ACTIVITY OF NOVEL 2-BENZIMIDAZOLYL AND 2-BENZOTHIAZOLYL SUBSTITUED BENZOTHIENO-2-CARBOXAMIDES Maja Cindrić, Mihaela Perić, Marijeta Kralj, Irena Martin-Kleiner, Hana Čipčić Paljetak, Mario Matijašić, Donatella Verbanac, Grace Karminski-Zamola and Marijana Hranjec

P-45 SYNTHESIS OF DIPEPTIDES CONTAINING PHOTOCHEMICALLY REACTIVE MODIFIYED TYROSINE AND EVALUATION OF THEIR DNA BINDING Antonija Husak, Josipa Matić, Ivo Piantanida and Nikola Basarić

P-46 TARGETED DEGRADATION OF ANAPLASTIC LYMPHOMA KINASE (ALK) BY APPLYING THE PROTEOLYSIS TARGETING CHIMERAS (PROTAC) Jong Yeon Hwang, Chi-Hoon Park, Dong Ho Lee, Chung Hyo Kang, Chong Ock Lee and Jae Du Ha

P-47 LIPOPHILICITY EVALUATION AND IN SILICO ADME-TOX STUDIES OF SOME NOVEL THIOSEMICARBAZONE AND 1,3,4-THIADIAZOLINE DERIVATIVES Ioana Ionuț, Gabriel Marc, Ovidiu Oniga and Brîndușa Tiperciuc

P-48 SYNTHESIS OF NOVEL RING STRUCTURES AS GABAA RECEPTOR LIGANDS WITH FUNCTIONAL SELECTIVITY Maria Teresa Iorio, Laurin Wimmer, Konstantina Bampali, Margot Ernst and Marko Mihovilovic

P-49 SYNTHESIS AND BIOLOGICAL EVALUATION OF CHALCONE DERIVATIVES AS NEUROPROTECTIVE AGENTS FOR PARKINSON’S DISEASE Bo Ko Jang, Ji Won Choi, Jong-Hyun Park, Seul Ki Yeon, Si Won Kim, Yerim Lee, Su Jeong Shin, Hyeon Jeong Kim, Hyeon Ji Kim, Yong Gu Kang, Ae Nim Pae and Ki Duk Park

P-50 SYNTHESIS, STRUCTURE-ACTIVITY RELATIONSHIPS, AND MOLECULAR MODELING STUDIES OF NEW LONG-CHAIN CHLOROARYLPIPERAZINES DERIVATIVES AS 5-HT7 AND 5-HT1A RECEPTOR LIGANDS Jolanta Jaśkowska, Paweł Śliwa, Zbigniew Majka, Anna K. Drabczyk, Damian Kułaga, Magdalena Malinowska and Grzegorz Satała

P-51 NEW METHODS FOR SYNTHESIS OF THE TRAZODONE ANTIDEPRESSANT Przemysław Zaręba, Jolanta Jaśkowska and Zbigniew Majka

P-52 PHENYLSULFONYL HYDRAZIDE DERIVATIVES AS NOVEL POTENT ANTI-INFLAMMATORY AGENTS Hui Rak Jeong, Sun Yeung Kim and Jae Yeol Lee

P-53 DESIGN, SYNTHESIS AND EVALUATION OF INDOLE DERIVATIVES AS MULTIFUNCTIONAL AGENTS AGAINST ALZHEIMER’S DISEASE Jacques Joubert, Ireen Denya and Sarel F. Malan

P-54 3,4-DIHYDROQUINAZOLINE DERIVATIVES AS NOVEL AND SELECTIVE BUTYRYLCHOLINESTERASE INHIBITORS Da Woon Jung, Jin Han Kim, Hong Bin Yoon and Jae Yeol Lee

P-55 HIGH THROUGHPUT SCREENING FOR DIPEPTIDYL PEPTIDASE III INTERACTING PROTEINS Snježana Jurić, Katarzyna Kliza, Koraljka Husnjak and Mihaela Matovina

P-56 IN VITRO, IN VIVO AND MOLECULAR MODELING STUDIES OF N-(3-{4-[3-(TRIFLUOROMETHYL)PHENYL]PIPERAZIN-1-YL}PROPYL)-1H-INDAZOLE-3-CARBOXAMIDE (D2AAK3) AS A POTENTIAL ANTIPSYCHOTIC Agnieszka A. Kaczor, Katarzyna M. Targowska-Duda, Marta Kruk-Słomka, Andrea G. Silva, Peter Kolb, Antti Poso, Grażyna Biała and Marian Castro

P-57 DIRECT PHOSPHONYLATION OF HETEROAROMATIC COMPOUNDS AS A MEAN TO SYNTHESIZE CYTOTOXIC AGENTS Ewa Chmielewska, Monika Prokopowicz, Natalia Wojtowicz, Joanna Wietrzyk, Piotr Młynarz and Paweł Kafarski



P-58 EVALUATION OF ANTIMYCOBACTERIAL ACTIVITY FOR A RANGE OF POLYCYCLIC AMANTADINE AND PENTACYCLOUNDECANE DERIVATIVES Erika Kapp, Jacques Joubert, Samantha L. Sampson, Margaretha de Vos and Sarel F. Malan

P-59 DEVELOPMENT OF A DISINFECTANT PRODUCT CONTAINING THE ESSENTIAL OIL EXTRACTED FROM ROSMARINUS OFFICINALIS L. Fetta Kessal, Amina Dahmoune, Amina Azzam, Boumrar Silia and Boualem Samia

P-60 DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF D-RING OPENED 17-β ESTRADIOL ANALOGUES AS ESTROGEN RECEPTOR SUBTYPE-SELECTIVE LIGANDS Sun Young Lee, Yun Seon Song, Minsun Chang and Hee-Doo Kim

P-61 SYNERGISTIC ANTICANCER EFFECT OF T-TYPE CALCIUM CHANNEL BLOCKER AND CHEMOTHERAPEUTIC AGENTS IN HUMAN LUNG CANCER Jin Han Kim, Hong Bin Yoon, Da Woon Jung and Jae yeol Lee

P-62 DISCOVERY OF PHENYLSULFONYL HYDRAZIDE DERIVATIVES AS NOVEL AND SELECTIVE mPGES-1 INHIBITORS Sun Young Kim, Hui Rak Jeong and Jae yeol Lee

P-63 RUTHENIUM-BASED CATALYSTS FOR ASYMMETRIC TRANSFER HYDROGENATION Andrea Kišić, Michel Stephan, Barbara Mohar, Andrej Emanuel Cotman, and Dominique Cahard

P-64 THE PREPARATION OF THE FOUR STEREOISOMERS OF 16-HYDROXYMETHYL-13-EPI-ESTRA-1,3,5(10)-TRIEN-17-OL-3-METHYL-, AND 3-BENZYLETHERS Anita Kiss, János Wölfling and Gyula Schneider

P-65 DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF CXCR3 AND CXCR4 MODULATORS WITH PYRAZOLOPYRIDINE SCAFFOLD Anja Kolarič, Urban Švajger, Tihomir Tomašič, Nikola Minovski, Nuška Tschammer and Marko Anderluh

P-66 CHEMICAL PROTEOMICS IN THE EVALUATION OF THE EGFRI LAPATINIB PHARMACOLOGY Tatjana Kovačević, Krunoslav Nujić and Milan Mesić

P-67 MEDICAL CHEMICAL DEFENCE AGAINST CHEMICAL NERVE AGENT THREATS Zrinka Kovarik, Nikolina Maček-Hrvat and Tamara Zorbaz

P-68 ANTITUMOR ACTIVITY OF ANTHROLS THAT PHOTOCHEMICALLY GENERATE QUINONE METHIDES OR REACTIVE OXYGEN SPECIES AND THEIR SELECTIVITY TOWARDS CANCER STEM CELLS Lidija Uzelac, Đani Škalamera, Kata Mlinarić-Majerski, Nikola Basarić and Marijeta Kralj

P-69 SURFACE INTERACTIONS BETWEEN OLIGOPEPTIDE DERIVATIVES OF SALICYLIC ACID AND CALCITE AS A MODEL OF AN INORGANIC DRUG DELIVERY SYSTEM Marko Ukrainczyk, Lara Štajner, Zlatko Brkljača, Robert Stepić, David Smith, Ana Sunčana Smith, Matija Gredičak, Ivanka Jerić, Andreja Jakas and Damir Kralj

P-70 OLIGOTUFTSIN-BASED CARRIERS FOR NOVEL ANTIMYCO-BACTERIAL ACTIVE AGENTS AND THEIR CONJUGATES Krátký Martin, Baranyai Zsuzsa, Szilvia Bősze, Szabó Nóra, Vinšová Jarmila

P-71 NOVEL 1,2,3-TRIAZOLYL-7-SUBSTITUTED COUMARINS AND BIS(COUMARIN-TRIAZOLYL)BENZENES: SYNTHESIS, PHOTOPHYSICAL PROPERTIES AND CYTOSTATIC EVALUATION Kristina Bobanović, Ema Horak, Lidija Furač, Marijeta Kralj, Lidija Uzelac, Ivana Murković Steinberg and Svjetlana Krištafor

P-72 DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL POTENT MDM2/P53 SMALL MOLECULE INHIBITORS M. E. Kukushkin, V. K. Novotortsev, V. E. Filatov, A. A. Beloglazkina, N. A. Vorobyeva, D. A. Skvortsov, E. K. Beloglazkina, N. V. Zyk and A. G. Majouga



P-73 SYNTHESIS AND BIOLOGICAL ACTIVITY OF NOVEL LONG CHAIN ARYLOPIPERAZINES (LACPs) WITH PYRIDYL MOIETY AS LIGANDS FOR SEROTONIN RECEPTORS Damian Kułaga, Jolanta Jaśkowska, Anna Drabczyk, Grzegorz Satała and Magdalena Malinowska

P-74 DIFFERENT ROLES OF HALOGEN SUBSTITUENTS IN LIGAND-RECEPTOR INTERACTIONS – A CLASS A GPCRS CASE STUDY Rafał Kurczab

P-75 SYNTHESIS AND BIOLOGICAL POTENTIAL OF SERIES A AND B MODIFIED STEROIDAL D-LACTONES Ivana Kuzminac, Marina Savić, Dimitar Jakimov, Olivera Klisuric, Andrea Nikolić and Marija Sakač

P-76 IN SILICO & IN VITRO EVALUATION OF NOVEL INHIBITORS OF MITOCHONDRIAL F1F0-ATPASE Dimitrios Karagiannis, Panagiotis Efentakis, George Lambrinidis, Ioanna Andreadou and Emmanuel Mikros

P-77 3-AROYL-1,4-DIARYLPYRROLES INHIBIT CHRONIC MYELOID LEUKEMIA CELL GROWTH THROUGH AN INTERACTION WITH TUBULIN Giuseppe La Regina, Valentina Naccarato, Antonio Coluccia, Addolorata Maria Luce Coluccia, Ernest Hamel and Romano Silvestri

P-78 INHIBITION OF DENGUE VIRUS BY NOVEL INHIBITORS OF RNA-DEPENDENT RNA POLYMERASE AND PROTEASE ACTIVITIES Giuseppe La Regina, Valeria Famiglini, Domiziana Masci, Antonio Coluccia, Jin-Ching Lee, John Hiscott and Romano Silvestri

P-79 PHENOXYMETHYL DERIVATIVES OF 1,3,5-TRIAZINE AS NOVEL CLASS OF 5-HT6 RECEPTOR LIGANDS Dorota Łażewska, Małgorzata Więcek, Michał Stelmasiński, Grzegorz Satała, Rafał Kurczab, Andrzej J. Bojarski, Katarzyna Kieć-Kononowicz and Jadwiga Handzlik

P-80 BLOCKADE OF RAS ACTIVITY BY INHIBITORS OF THE ENZYME ISOPRENYLCYSTEINE CARBOXYL METHYLTRANSFERASE (ICMT) S. Ortega-Gutiérrez, M. Martín-Fontecha, N. Marín-Ramos, F.J. Ortega, A. Gil, M. Balabasquer, I. Cushman, I.R. Torrecillas, L. Pardo, P.J. Casey, M.R. Philips and M.L. López-Rodríguez

P-81 STUDY FOR THE DEVELOPMENT OF NEW PURINE ANALOGUES AS HIGHLY SPECIFIC LIGANDS AGAINST FUNGAL NUCLEOBASE TRANSPORTERS Efthymios-Spyridon Gavriil, Spyridon Dimitrakis, Nikolaos Lougiakis, George Lambrinidis, Emmanuel Mikros, Panagiotis Marakos, Nicole Pouli and George Diallinas

P-82 SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL SMALL-MOLECULE PSMA-TARGETED PACLITAXEL CONJUGATES A.E. Machulkin, A.P. Ber, I.V. Saltykova, E.K. Beloglazkina, N.V. Zyk, V.E Koteliansky, and A.G. Majouga

P-83 DESIGN, SYNTHESIS AND IN VITRO EVALUATION OF MODULATORS OF PFKFB3 AUTOREGULATORY DOMAIN H.Macut, X.Hu, D.Tarantino, S.Pellegrino and M.L.Gelmi

P-84 ISOXAZOLE DERIVATIVES AS IMMUNOMODULATORS Marcin Mączyński, Angelika Drynda, Stanisław Ryng and Bożena Obmińska-Mrukowicz

P-85 PYRROLYL NON-DKA DERIVATIVES AS NOVEL INHIBITORS OF HIV-1 REVERSE TRANSCRIPTASE-ASSOCIATED RIBONUCLEASE H FUNCTION V.N. Madia, F. Saccoliti, G. Pupo, V.Tudino, F. Esposito, A. Corona, N. Grandi, E. Tramontano, R. Costi and R.Di Santo

P-86 NOVEL ANTIMALARIALS FROM NATURE: EVOLUTIONARY GENERATED VIRTUAL COMPOUND LIBRARIES FROM NATURAL PRODUCTS WITH ANTIPLASMODIAL ACTIVITIES Samuel Egieyeh, James Syce, Alan Christoffels and Sarel Malan



P-87 THE SYNTHESIS OF NEW ARYLPIPERAZINES FOR CNS DISORDERS Magdalena Malinowska, Jolanta Jaśkowska, Anna Drabczyk and Damian Kułaga

P-88 BIOLOGICAL EVALUATIONS OF AMIDINE AND AMIDOXIME SUBSTITUTED HETEROCYCLES WITH 1,2,3-TRIAZOLYL SPACER Silvija Maračić, Petra Grbčić, Mirela Sedić, Sandra Kraljević Pavelić and Silvana Raić-Malić

P-89 DESIGN, SYNTHESIS AND CYTOTOXIC ACTIVITY EVALUATION OF NEW AMINOSUBSTITUTED PYRAZOLOPYRIDINES Nikolaos Lougiakis, Vasiliki Giannouli, Ioannis K. Kostakis, Panagiotis Marakos, Nicole Pouli, Orestis Argyros and Constantin Tamvakopoulos

P-90 IN VITRO CITOTOXITY AND ANTI-TUMOR INVESTIGATION OF PHENYLBORONIC ACID Maja Marasović, Mladen Miloš, Siniša Ivanković and Ranko Stojković

P-91 MICROWAVE ASSISTED SYNTHESIS OF SOME NEW THIAZOLIDINE-2,4-DIONE DERIVATIVES AS POTENTIAL ANTIMICROBIAL AGENTS Gabriel Marc, Ioana Ionuț, Dan Vodnar, Adrian Pîrnău, Brîndușa Tiperciuc and Ovidiu Oniga

P-92 WEB-4D-QSAR OF 17β-HYDROXYSTEROID DEHYDROGENASE TYPE 3 INHIBITORS Eduardo B. de Melo, Tuanny P. Schmidt and João Paulo A. Martins

P-93 WEB-4D-QSAR OF URACIL DERIVATIVES DESCRIBED AS THYMIDINE PHOSPHORYLASE INHIBITORS João Paulo A. Martins and Eduardo B. de Melo

P-94 SYNTHESIS AND DETERMINATION OF PHYSICOCHEMICAL PROPERTIES OF NEW POTENTIAL ANTIMYCOBACTERIAL DRUGS Pavlína Marvanová, Tereza Padrtová, Klára Odehnalová, Otakar Humpa and Petr Mokrý

P-95 EXPLORATION OF NEW ANTICANCER CHEMOTHERAPEUTIC AGENTS BASED ON ANTITUMOR NATURAL PRODUCT ANDRASTINS Shuqiang Yin, Quan Li, Aki Kohyama, Kenji Sugimoto and Yuji Matsuya

P-96 DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL PYRROLE-BASED AS EZH2 INHIBITORS R. Mazzone, C. Zwergel, M. Tafani, A. Nebbioso, L. Altucci, A. Mai and S. Alente

P-97 SYNTHESIS OF NOVEL 13α-ESTRONE DERIVATIVES AS POTENTIAL 17β-HSD1 INHIBITORS Ildikó Bacsa, Rebeka Jójárt, János Wölfling, Gyula Schneider, Bianka Edina Herman, Mihály Szécsi and Erzsébet Mernyák

P-98 ANTITUMORAL AND ANTIVIRAL ACTIVITIES OF NOVEL 1,2,3-TRIAZOLYL APPENDED L-ASCORBIC ACID DERIVATIVES Andrijana Meščić, Anja Harej, Višnja Stepanić, Sandra Kraljević Pavelić, Dominique Schols and Silvana Raić-Malić

P-99 IDENTIFICATION OF NEW INHIBITORS OF PRMTs BY A MULTI-SUBSTRATE-ADDUCT APPROACH C. Milite, D. Rescigno, A. Feoli, S. Castellano and G. Sbardella

P-100 SYNTHESIS AND EVALUATION OF NEW N-ACYLETHANOLAMINES PPAR-α LIGANDS PLANNED FROM CARDANOL Camila de Oliveira Miranda, Carolyn Cummins and Luiz A Soares Romeiro

P-101 DEVELOPMENT OF NOVEL REAGENTS FOR GENERATING ISLETS Β-CELLS AND ENHANCING THEIR FUNCTION BASED ON CLUSTERED NANOFORMULATION OF NEUROLIGIN-2 MIMETICS Munder Anna, Shtriker Efrat, Viskind Olga, Korshin Edward, Chessler Steven, and Gruzman Arie



P-102 TARGETING PLASMODIUM FALCIPARUM GLUCOSE-6-PHOSPHATE DEHYDROGENASE IN THE PURSUIT OF NOVEL ANTIMALARIAL AGENTS Diego Muñoz-Torrero, Nelson Alencar, Irene Sola, María Linares, Caterina Pont, Luca Di Palma, Carla Barbaraci, Cristina Sampedro, Jordi Juárez-Jiménez, Paloma Abad, Susana Pérez-Benavente, Jerónimo Lameira, José M. Bautista and F. Javier Luque

P-103 A SYNTHESIS OF “DUAL WARHEAD” β ARYL ETHENESULFONYL FLUORIDES AND ONE-POT REACTION TO β SULTAMS Praveen K. Chinthakindi, Kimberleigh B. Govender, A. Sanjeeva Kumar, Hendrik G. Kruger, Thavendran Govender, Tricia Naicker and Per I. Arvidsson

P-104 SYNTHESIS AND CYTOTOXIC PROPERTIES OF NEW DERIVATIVES OF BENZOFURANS M. Napiórkowska, M. Cieślak, K. Królewska, J. Kaźmierczak-Barańska and B. Nawrot

P-105 INVESTIGATION OF THE ANTIPROLIFERATIVE AND ANTIHYPERGLYCEMIC ACTIVITIES OF NEW THIAZOLIDINEDIONE DERIVATIVES Cristina Nastasă, Daniel Scherman, Alina Pârvu, Ovidiu Oniga and Brîndușa Tiperciuc

P-106 ANTICARCINOGENIC POTENTIAL OF PLUM (Prunus domestica L.) KERNEL EXTRACTS OBTAINED BY SUBCRITICAL WATER Nataša Nastić, Slavica Ražić, Ana Damjanović, Aleksandra Cvetanović, Višnja Gaurina Srček, Igor Slivac, Kristina Radošević and Jaroslava Švarc-Gajić

P-107 IN VITRO SCREENING OF ANTICARCINOGENIC PROPERTIES OF CHERRY STEM EXTRACTS OBTAINED BY SUBCRITICAL WATER Nataša Nastić, Višnja Gaurina Srček, Kristina Radošević, Igor Slivac, Aleksandra Cvetanović, Vesna Novakov and Jaroslava Švarc-Gajić

P-108 DESIGN, SYNTHESIS AND ANTICONVULSANT ACTIVITY OF NEW PIPERAZINAMIDES DERIVED FROM 3-ISOBUTYL-2,5-DIOXOPYRROLIDIN-1-YL-ACETIC ACID Jolanta Obniska, Małgorzata Góra, Sabina Rybka, Krzysztof Kamiński and Anna Rapacz

P-109 IDENTIFICATION OF 3-[3, 4-BIS-(TERT-BUTYL-DIMETHYL-SILANYLOXY)-PHENYL]-PROPIONIC ACID AS AN ADIPONECTIN EXPRESSION ENHANCER Tsutomu Oikawa, Motomu Inoue, Yurie Ueno, Atsuko Motojima, Nobuyasu Matsuura, Tomio Saito and Hiroyuki Osada

P-110 SYNTHESIS AND BIOLOGICAL ACTIVITY OF 3-AMINOTHYMOQUINONE Una Glamočlija, Subhash Padhye, Selma Špirtović-Halilović, Amar Osmanović, Elma Veljović, Sunčica Roca, Irena Novaković, Sandra Kraljević Pavelić, Anja Harej and Davorka Završnik

P-111 SYNTHESIS AND ANTICONVULSANT ACTIVITY OF NEW PHENOXYACETHAMIDE DERIVATIVES OF AMINES, AMINOALKANOLS OR AMINO ACIDS Katarzyna Pańczyk, Anna Waszkielewicz, Dorota Żelaszczyk, Ewa Żesławska, Karolina Słoczyńska, Paulina Koczurkiewicz, Elżbieta Pękala and Henryk Marona

P-112 THEORETICAL PREDICTION OF LIPOPHILICITY OF THIOSEMICARBAZIDE DERIVATIVES Agata Paneth, Tomasz Plech, Dominika Janowska, Szymon Kosiek, Nazar Trotsko, and Monika Wujec

P-113 NOVEL SPIRO CARBOCYCLIC HYDANTOIN-DERIVATIVES WITH POTENT ANTITRYPANOSOMAL ACTIVITY Vasiliki Pardali, Martin C. Taylor, John M. Kelly and Grigoris Zoidis

P-114 SYNTHESIS AND BIOLOGICAL EVALUATION OF HYDROXAMATE COMPOUNDS AS HDAC6 INHIBITORS Hui Yeon Mok, Han Pyo Son, Seung Yeop Baek, Hyun-Ju Park and Young Hoon Jung

P-115 DRUG DESIGN AND SYNTHESIS OF NEW INDOLYLARYLSULFONES AS HIV-1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS S. Passacantilli, V. Famiglini, G. La Regina, A. Coluccia, D.Masci, J. A. Estè, G. Maga and R. Silvestri



P-116 NEW (AMINOMETHYLENE)BISPHOSPHONATES OBTAINED FROM HETEROCYCLIC AMINES AND THEIR BIOLOGICAL ACTIVITY Patrycja Miszczyk, Ewa Chmielewska, Błażej Dziuk, Joanna Wietrzyk and Paweł Kafarski

P-117 Abstract retracted for technical reasons

P-118 Abstract retracted for technical reasons

P-119 SYNTHESIS, ANTIBACTERIAL ACTIVITY AND SAR STUDY OF NOVEL AMIDINO 2-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES Nataša Perin, Marijana Hranjec, Mihaela Perić, Hana Čipčić Paljetak, Mario Matijašić, Višnja Stepanić, Donatella Verbanac, Grace Karminski-Zamola and Kristina Starčević

P-120 CHEMICAL COMPOSITION AND BIOACTIVE EFFECTS OF LAVENDER ESSENTIAL OIL FROM MONTENEGRO Svetlana Perović, Snežana Pantović, Valentina Šćepanović, Andrej Perović and Biljana Damjanović-Vratnica

P-121 NOVEL СONJUGATES OF DOXORUBICIN WITH ASGP-RECEPTOR LIGANDS FOR TARGETED DELIVERY R.A. Petrov, S.A. Petrov, E.E. Ondar, S.Yu Maklakova, I.V. Saltykova, E.K. Beloglazkina, A.G. Majouga and V.E. Kotelianski

P-122 SYNTHESIS, CHARACTERIZATION AND CYTOTOXICITY OF PHENOLIC COPPER(II) COMPLEXES Vladimir P. Petrović, Dušica Simijonović, Zorica D. Petrović, Marko N. Živanović and Snežana D. Marković

P-123 THIOSEMICARBAZIDE DERIVATIVES WITH 4-NITROPHENYL GROUP AS MULTI-TARGET DRUGS Monika Pitucha, Małgorzata Miazga-Karska, Agnieszka A. Kaczor, Katarzyna Klimek, Zbigniew Karczmarzyk, Maciej Woś, Waldemar Wysocki, Grazyna Ginalska, Zofia Urbanczyk-Lipkowska and Maja Morawiak

P-124 DESIGN AND SYNTHESIS OF NEW SUBSTITUTED NUCLEOSIDES AS POTENTIAL ANTI-HCMV AGENTS Maria Gerasi, Georgios Papadakis, Nikolaos Lougiakis, Panagiotis Marakos and Nicole Pouli

P-125 SCREENING PHYSIOLOGICALLY RELEVANT SUBSTRATES OF ALDOSE REDUCTASE: ENZYME ACTIVITIES AND DIFFERENTIAL INHIBITION Marta Soltesova Prnova, Jana Ballekova, Yoel Rodriguez, Magdalena Majekova and Milan Stefek

P-126 POST HEROIN DOSE TISSUE DISTRIBUTION OF 6-MONOACETYLMORPHINE (6-MAM) WITH MALDI IMAGING Belin G Teklezgi, Annapurna Pamreddy, Sooraj Baijnath, Nirmala D Gopal, Tricia Naicker, Hendrik G Kruger and Thavendran Govender

P-127 RATIONAL DESIGN OF NEW POTENT NON-NUCLEOSIDE INHIBITORS OF TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE ACTIVE IN LEUKEMIC CELLS G. Pupo, A. Coluccia, A. Messore, N. V. Madia, F.Saccoliti, L. Pescatori, R. Costi, G. Maga, E. Crespan and R. Di Santo

P-128 SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL 2-(HETERO)ARYL-6-(2-IMIDAZOLINYL)BENZOTHIAZOLES AS ANTICANCER AGENTS Livio Racané, Lucija Ptiček, Mirela Sedić, Petra Grbčić, Sandra Kraljević Pavelić, Irena Sović, Grace Karminski-Zamola

P-129 NEW PRIMAQUINE AMIDES WITH HYDROXYPHENYL AND HALOGENPHENYL SUBSTITUENTS Zrinka Rajić Džolić, Maja Beus and Branka Zorc

P-130 SYNTHESIS AND EVALUATION OF MULTI-TARGET LIGANDS PLANNED FROM CARDANOL FOR THE

TREATMENT OF ALZHEIMER'S DISEASE Giselle de Andrade Ramos, Luiz A. Soares Romeiro, Manuela Bartolini, Paul E. Fraser and Ling Wu



P-131 DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL G9A INHIBITORS FROM A SCAFFOLD HOPPING APPROACH D. Rescigno, C. Milite, M. Viviano, S. Castellano and G. Sbardella

P-132 SYNTHESIS OF MULTIANTENNARY MANNOSE DERIVED DESMURAMYL PEPTIDES Rosana Ribić, Marija Paurević, Nora Tir and Srđanka Tomić

P-133 MOLECULAR MODELING AND SYNTHESIS OF PYRUVATE DEHYDROGENASE KINASE INHIBITORS AS A POTENTIAL ANTICANCER TARGETS Agata Rosińska, Urszula Kijkowska-Murak and Dariusz Matosiuk

P-134 DISCOVERY OF NOVEL DIARYL SULFIDE DERIVATIVES AS INHIBITORS OF TRYPANOTHIONE REDUCTASE ENZYME F. Saccoliti, V. N. Madia, G. Pupo, V. Tudino, G. Colotti, G. Angiulli, A. Fiorillo, P. Baiocco, T. Di Muccio, M. Gramiccia, L. Scipione, R. Costi, A. Ilari and Di Santo R

P-135 PSORALENE DERIVATIVES INHIBITORS OF THE β5i SUBUNIT OF THE IMMUNOPROTEASOME Eva Shannon Schiffrer, Izidor Sosič, Martina Gobec, Irena Mlinarič-Raščan and Stanislav Gobec

P-136 THE APPLICATION OF FMO-EDA CALCULATION TO STUDY THE SELECTIVITY OF 2-CHLOROPHENYL-PIPERAZIN DERIVATIVE TO SEROTONIN AND DOPAMINE RECEPTORS Paweł Śliwa, Jolanta Jaśkowska and Rafał Kurczab

P-137 AN ASPARTATE-AMINE SALT BRIDGE – THE ETS-NOCV STUDY Paweł Śliwa, Rafał Kurczab and Andrzej J. Bojarski

P-138 STEROID RECEPTOR BINDING AFFINITIES OF SELECTED MODIFIED STEROIDS- A SCREENING TOOL FOR IDENTIFICATION OF POTENTIAL THERAPEUTICS Sofija S. Bekić, Marija N. Sakač, Suzana S. Jovanović-Šanta, Edward T. Petri and Andjelka S. Ćelić

P-139 DEVELOPMENT OF BIOORTHOGONAL 2-NITROIMIDAZOLE BASED HYPOXIA SENSITIVE PROBES Barbara Sohr, Christoph Denk, Thomas Wanek and Hannes Mikula

P-140 NEUROPROTECTIVE POTENTIAL OF LINEZOLID: A QUANTITATIVE AND DISTRIBUTION STUDY VIA MASS SPECTROMETRY Sooraj Baijnath, Chivonne Moodley, Bongani Ngcobo, Sanil D. Singh, Gert Kruger, Per I. Arvidsson, Tricia Naicker, Alexander Pym and Thavendran Govender

P-141 SYNTHESIS, ANTITUMOR AND ANTIOXIDATIVE ACTIVITY OF NITRO AND AMINO SUBSTITUTED BENZIMIDAZOLE AND BENZOTHIAZOLE 2-CARBOXAMIDES Irena Sović, Ida Boček, Petra Roškarić, Marijeta Kralj, Irena Martina Kleiner, Kristina Starčević and Marijana Hranjec

P-142 ESTIMATION OF BINDING AFFINITY FOR SOME SYNTHESIZED COUMARIN DERIVATIVES WITH RECEPTORS IMPORTANT FOR BACTERIAL GROWTH AND DEVELOPMENT Selma Špirtović-Halilović, Elma Veljović, Mirsada Salihović, Aida Šapčanin, Amar Osmanović, Nihada Škrijelj and Davorka Završnik

P-143 ANTIBACTERIAL THIAZOLIN-4-ONES AS POTENTIAL DNA GYRASE AND TOPOISOMERASE IV INHIBITORS Anca Stana, Radu Tamaian, Dan C. Vodnar, Ovidiu Oniga and Brînduşa Tiperciuc

P-144 DESIGN, SYNTHESIS, X-RAY STUDIES AND BIOLOGICAL EVALUATION OF NOVEL CHALCONE DERIVATIVES – POTENTIAL MICROTUBULE TARGETING AGENTS Tomasz Stefanski, Rafał Kurczab, Artur Korzanski, Katarzyna Skonieczka, Barbara Grolik, Emilia Kania, Barbara Bojko, Zbigniew Dutkiewicz, Agnieszka Gielara-Korzańska, Renata Mikstacka, Adam Hogendorf and Maciej Kubicki



P-145 OPIOID RECEPTOR ACTIVITY AND ANALGESIC POTENCY OF DPDPE PEPTIDE ANALOGUES CONTAINING A XYLENE BRIDGE Azzurra Stefanucci, Giorgia Macedonio, Ettore Novellino, Sako Mirzaie, Stefano Pieretti, Paola Minosi, Edina Szúcs, Anna I. Erdei, Ferenc Zador, Sandor Benyhe and Adriano Mollica

P-146 IDENTIFICATION OF NOVEL STAT3 INHIBITORS AND SYNTHESIS-ASSISTED ELUCIDATION OF MOLECULAR MECHANISM Seungbeom Lee, Changjin Lim, Joonseong Hur and Young-Ger Suh

P-147 HIGHLY REACTIVE DIENOPHILES FOR BIOORTHOGONAL TETRAZINE LIGATIONS Dennis Svatunek, Maximilian Haider and Hannes Mikula

P-148 SYNTHESIS AND CYTOTOXIC ACTIVITY OF NEW DERIVATIVE OF ISOTHIAZOLOPYRIDINE Piotr Świątek, Agnieszka Matera-Witkiewicz, Karolina Królewska-Golińska, Julia Kaźmierczak-Barańska, Marcin Cieślak and Barbara Nawrot

P-149 STUDIES ON ARYL-SUBSTITUTED PHENYLALANINES: SYNTHESIS, ACTIVITY AND DIFFERENT BINDING MODES AT AMPA RECEPTORS Ewa Szymańska, Birgitte Nielsen, Darryl S. Pickering and Tommy N. Johansen

P-150 NOVEL AND EFFICIENT BICYCLIC GUANIDINE CATALYST FOR THE CYCLOTRIMERIZATION OF ISOCYANATES. A QUANTUM CHEMICAL STUDY. Tana Tandarić and Robert Vianello

P-151 DESIGN AND SYNTHESIS OF DUAL G9A METHYLTRANSFERASE/LSD1 DEMETHYLASE OR SELECTIVE LSD1 INHIBITORS BY STRUCTURAL MANIPULATION OF THE QUINAZOLINE SCAFFOLD Daniela Tomaselli, Alessia Lucidi, Mariantonietta Forgione, Gebremedhin Solomon Hailu, Valentina Speranzini, Biagina Marrocco, Simona Pilotto, Andrea Mattevi, Dante Rotili and Antonello Mai

P-152 HOMOLOGY MODELLING, STRUCTURE- AND LIGAND-BASED DRUG DESIGN OF NOVEL CALCIUM CHANNEL BLOCKERS WITH LEISHMANICIDAL ACTIVITIES Carlos Henrique Tomich de Paula da Silva, Leonardo Bruno Federico, Laura M. Alcântara, Carolina B. Moraes, Lucio H. Freitas-Júnior and Joaquín M. Campos Rosa

P-153 NOVEL D- GLUCOSAMINE N- PEPTIDYL DERIVATIVES ENDOWED WITH SELECTIVE ACTIVITY TOWARDS IKK ALPHA V. Tudino, V. N. Madia, F. Saccoliti, G. Pupo, R. Cocchiola, A. Scotto D’Abusco, R. Scandurra, R. Costi and R. Di Santo

P-154 MEMANTINE ANALOGUES WITH ACTIVITY AS GLUTAMATE N-METHYL D-ASPARTATE RECEPTOR ANTAGONISTS Andreea L.Turcu, Daina Martínez-Falguera, Francesc X. Sureda and Santiago Vázquez

P-155 NOVEL THIAZOLES AS TRYPANOCIDAL AGENTS Santiago Vázquez, Rosana Leiva, Jèssica Rubí, Martin C. Taylor, Belén Pérez and John M. Kelly

P-156 FLUORINATED PHENYLALANINE DERIVATIVES: VERSATILE BIOLOGICAL ACTIVITY Martin Krátký, Jarmila Vinšová, Šárka Štěpánková, Jiřina Stolaříková

P-157 DISCOVERY OF THE FIRST-IN-CLASS CHEMICAL PROBES FOR THE SPINDLIN1 METHYL-LYSINE READER DOMAIN M. Viviano, S. Castellano, M. T. Bedford, H. Li and G. Sbardella

P-158 HYDRAZINO PEPTIDOMIMETICS AS MODULATORS OF PROTEIN-PROTEIN INTERACTIONS Kristina Vlahoviček-Kahlina, Luka Kavčič, Marija Marković, Janez Plavec, Ivo Piantanida, and Ivanka Jerić

P-159 SALICYLANILIDE MUTUAL PRODRUGS: SYNTHESIS AND BIOLOGICAL ACTIVITY R. Vosátka, M. Krátký, J. Vinšová



P-160 SYNTHESIS AND PHARMACOLOGICAL ACTIVITY IN A GROUP OF PHENOXYALKYL DERIVATIVES OF PIPERAZINE Anna M. Waszkielewicz, Katarzyna Pańczyk, Karolina Pytka, Anna Rapacz, Monika Głuch-Lutwin, Agata Siwek, Adam Bucki, Marcin Kołaczkowski and Henryk Marona

P-161 STRUCTURE-ACTIVITY RELATIONSHIP STUDY OF INTERVENOLIN, A NATURAL QUINOLONE WITH ANTI-TUMOR AND ANTI-HELICOBACTER PYLORI ACTIVITIES Takumi Watanabe, Hikaru Abe, Manabu Kawada, Chiharu Sakashita, Shun-ichi Ohba, Hiroyuki Inoue, Tomokazu Ohishi, Tohru Masuda, Chigusa Hayashi, Masayuki Igarashi and Masakatsu Shibasaki

P-162 DISCOVERY OF ISOQUINOLINOQUINAZOLINONES AS A NOVEL PPAR GAMMA ANTAGONISTS Yifeng Jin,Younho Han, Daulat B. Khadka, Kwang Youl Lee and Won-Jea Cho

P-163 SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NEW S-TRIAZOLE DERIVATIVES M. Wujec, A. Paneth, Ł. Popiołek, T. Plech, Sz. Kosiek, E. Kędzierska and J. Kotlińska

P-164 DEVELOPMENT OF THE METHOD FOR HPLC ASSAY OF THE LIMОNIUM GMЕLINII DRY EXTRACT G.Е. Zhussupova, D.T. Kassymova, A.I. Zhussupova

P-165 STRUCTURE-ACTIVITY AND MECHANISTIC STUDY OF INHIBITORY EFFECTS OF POLYSUBSTITUTED PYRIMIDINES ON PROSTAGLANDIN E2 PRODUCTION Zdeněk Zídek, Zlatko Janeba, Petr Jansa, Miloslav Kverka, Eva Kmoníčková, Filip Kalčic and Viktor Kolman

P-166 DESIGN AND ANTIMYCOBACTERIAL EVALUATION OF COMPOUNDS COMBINING PYRAZINAMIDE AND PARA AMINOBENZOIC ACID Jan Zitko and Martin Doležal

P-167 BIOLOGICAL ACTIVITY OF NOVEL PRIMAQUINE-CINNAMIC ACID CONJUGATES OF THE ACYLSEMICARBAZIDE TYPE K. Pavić, K. Ester, M. Kralj, D. Schols, D. Hadjipavlou-Litina, E. Pontiki and B. Zorc

P-168 ANTIMYCOBACTERIAL SCREENING OF FOUR SERIES OF PRIMAQUINE DERIVATIVES Josef Jampílek, Sarka Pospíšilová, H. Michnová, Kristina Pavić, Ivana Perković and Branka Zorc

P-169 INSIGHTS INTO ANTIOXIDANT AND CYTOSTATIC ACTIVITY OF THE NOVEL PRIMAQUINE UREIDOAMIDES Branka Zorc, Kristina Pavić, Dimitra Hadjipavlou-Litina, Eleni Pontiki, Marijeta Kralj and Katja Ester

P-170 NITROGEN BASICITY AFFECTS ALDOSE REDUCTASE INHIBITION IN A SERIES OF 5-CARBOXYMETHYLATED TETRAHYDROPYRIDOINDOLES: STRUCTURE-ACTIVITY RELATIONSHIPS AND MOLECULAR MODELING Jana Ballekova, Marta Soltesova Prnova, Milan Stefek and Magdaléna Májeková

P-171 CAN THE BCHE POLYMORPHISM AFFECT THE INHIBITION POTENCY OF CARBAMYLATING AND REVERSIBLE INHIBITORS FROM EVERYDAY LIFE? Anita Bosak and Zrinka Kovarik

P-172 ANTIMALARIAL SCREENING OF PRIMAQUINE DERIVATIVES AGAINST ERYTHROCYTIC STAGE OF P. falciparum B. Zorc, K. Pavić, F. Supek, J. Levatić, and M. Kaiser



S O C I A L E V EN TS

o On Sunday, June 25, the opening ceremony with live performance will start at 17:00.

o At 19:30, a welcome party will be held in the Sheraton Dubrovnik Riviera Hotel.

o Trip to Dubrovnik, optional excursion will be organized on Monday, June 26. The trip will consist of a boat ride on a galleon ship Tirena to Dubrovnik, followed by a guided tour of the city.

o Gala Dinner with will be held on Tuesday, June 27 at 20:00 in the Sheraton Dubrovnik Riviera Hotel.

Galleon ship Tirena



V E N U E & A C C E SS

The 10th Joint Meeting on Medicinal Chemistry will be held in Dubrovnik, Croatia, 25–28 June 2017 at the Sheraton Dubrovnik Riviera Hotel. The Sheraton Dubrovnik Riviera Hotel is a new 5 hotel opened in August 2015 and have the largest hotel congress center in Croatia. It is located in Srebreno, just a few minutes drive from the historic Old Town of Dubrovnik. Nestled in a quiet cove the hotel offers spectacular views over the Adriatic sea, numerous islands and islets.

The Sheraton Dubrovnik Riviera Hotel

Dubrovnik is excellently accessible by all means of transportation.

By plane: Dubrovnik Airport is easy reachable by public transportation or taxi. It is is located about 12 km from the Conference Venue at Sheraton Dubrovnik Riviera Hotel in Srebreno, and 20 km from the center of Dubrovnik.

By bus: Dubrovnik is also easily reached by bus. It has good connection with domestic and international cities. All intercity and international bus travel departs from and arrives at the Main Bus Station, located in Gruž Port in Dubrovnik. The distance to Old Town Dubrovnik is about 3 km. There is also a taxi station right in front of the bus terminal.

By car: If you choose to drive then the recommended way is to follow the highway to Split, than to Ploče and from there continue to Dubrovnik following the Adriatic coast road. The view and feel along this Adriatic road is miraculous although the road may be strenuous for those not used to driving.



Public bus transport: All city districts are excellently connected with frequent regular bus lines of the Libertas Public Transport Company. The public bus time-tables are available at the Dubrovnik Tourist Board Information Offices and at all hotels reception desk as well as at the end of this programme book.

DUBROVNIK is one of the most prominent tourist and conference destinations in the Mediterranean. In 1979, the city of Dubrovnik joined the UNESCO list of World Heritage Sites. Unique for its impressive medieval forts, churches, monuments and palaces, Dubrovnik is often called the “pearl of the Adriatic”. George Bernard Shaw, visited the city in 1929 and said: “If you want to see heaven on earth, come to Dubrovnik”. Dubrovnik is among the several best preserved medieval walled cities in the world – its walls run almost 2 km around the city. The system of turrets and towers were intended to protect the city. The walls of Dubrovnik have also been a popular filming site for HBO’s Game Of Thrones and of the new episode of the 'Star Wars'. Its coastal belt is adorned with several marinas, piers and promenades. Because of a magnificent view on the mediaeval Dubrovnik, a walk along the city walls is exceptional experience. One of the reasons for visiting Dubrovnik besides its profound beauty and historic magic are warm, mild climate and Mediterranean gastronomic delight.



ATTRACTIONS

City walls, symbol of the town and the most important feature of Dubrovnik. Impressive Middle Age construction with corner towers of Minceta, Revelin, Bokar and Sveti Ivan protected Dubrovnik throughout its history.

The Rector's palace was the most important public building in Dubrovnik, the centre of government in the old Dubrovnik Republica. Famous inscription “Obliti privatorum publica curate” or “Forget your private business, concern yourself with public affairs” can be found above the entrance of the Rector’s Palace.

Stradun (Placa) is the main “artery” of the city, stretched between the two town gates, the gate of Pile and Ploce. Placa or Stradun street is the most favored promenade and gathering place of Dubrovnik.

The Sponza Palace, also known as Divona (from dogana, customs), was built in 1520 in a mixed late gothic and renaissance style. It served a variety of public functions, including as a customs office. Now it is the State Archive where the most important documents about Dubrovnik’s history are kept.

Franciscan monastery is a wonderful work of Dubrovnik architecture and one of the most prominent Dubrovnik attractions. It contains the third oldest pharmacy in the whole world (founded in 1317), continuously functioning until present day, and a very rich library with large number of preserved manuscripts of invaluable cultural and historical value.

The Church of St. Blaise (Crkva Sv. Vlaha) is an 18th-century baroque church on Luza Square dedicated to the patron saint and protector of Dubrovnik. This church is located at the intersection of two main thoroughfares, ‘Placa’ and Pred dvorom’.

Orlando's column, the symbol of Dubrovnik’s independence and freedom, is located at the eastern end of Placa (Stradun) street.

PROGRAMME - jmmc2017.hr · PROGRAMME. ORGANISER Section of Medicinal/Pharmaceutical Chemistry of...

Documents

Transcript of PROGRAMME - jmmc2017.hr · PROGRAMME. ORGANISER Section of Medicinal/Pharmaceutical Chemistry of...