CURRICULUM VITAE

Professor Dr.

Abdel-Rhman Barakat. Ahmed. El-Gazzar

Ph.D.

Personal:

Address: Chemistry Dept.,

College of Science,

Al-Imam Muhammad Ibn Saud Islamic University,

P.O. Box 90950, Riyadh 11623,

Saudi Arabia.

Voice: (+966)543215561

Fax : (+966)(01)-2591678

profelgazzar@yahoo.com

abgazzar@imam.edu.sa

Place of birth: Egypt.

Academic:

Ph.D., 1996:

Konstanz University Germany + Cairo University, Cairo, Egypt.

Dissertation: ″ Synthesis and Reactions of Polycondensed

Heterocycles: Thieno-azolo-, Thienopyrimido- and Thienoazolo-

pyrimidoazines″.

M.Sc., 1991: Zagazig University, C, Egypt.

Dissertation: ″ Synthesis and Reactions of Some Dibenzo-suberon

Derivatives of Expected Biological Activity ″.

B.Sc., 1986: Chemistry Department, Faculty of Science, Zagazig University,

Egypt.

Employment:

2008:

Professor, Applied Organic Chemistry Dept., National Research

Centre (Heterocyclic and Neucleosides Unit), Cairo, Egypt.

2002 - 2008:

Assistance Professor, Photochemistry Dept., National Research

Centre (Heterocyclic and Neucleosides Unit), Cairo, Egypt.

1996 - 2002:

Lecture, Applied Organic and Photochemistry Dept., National

Research Centre, Cairo, Egypt.

1992 - 1996:

Lecture Associate, Applied Organic Chemistry Dept., Konstanz

University (Germany) and National Research Centre, Cairo, Egypt.

1992 - 1996: Ph.D. graduate student, Chemistry Department, Faculty of Science,

Konstanz University and Cairo University, Cairo, Egypt.

1989 - 1991:

M.Sc. graduate student, Chemistry Department, Faculty of Science,

Zagazig University and National Research Centre, Cairo, Egypt.

Research interests:

1. Experience in synthetic and medicinal organic chemistry; The synthesis of

new heterocycles with potent biological activities; The regioselectivity and

reaction mechanisms of cycloaddition reactions of nitrilimines and

azoniaallene; The stereoselectivite synthesis of N2-arylamidrazones; Synthesis

and reactivity of enaminones, carbohydrazides and aroyacetonitriles,

Neucleosides analougas.

2. Expertise in the using of microwave irradiation as a mean of green chemistry

in the preparation of heterocyclic compounds (Microwave reactor, Initiator-

2.5, Biotage, Sweden and Microwave reactor, Explorer-48, CEM, USA).

3. Design, synthesis and evaluation of small combinatorial libraries with

potential biological activity.

4. Familiarity with the modern technique of chromatography separation (Flash

chromatography separation).

5. Familiarity with the utility of X-ray diffraction analyses in absolute

determination of organic structures and the role of hydrogen interactions in

directing the molecular assembly in solid stat of organic structures.

6. Extensive use and interpretation of instrumental data, including Mass

Spectrometry, IR, UV, 1H, 13C and 2D-NMR spectroscopy.

Some Funded Research projects (Not All):

1. Synthesis of some novel pyrazoles and evaluation of their anti-inflammatory

activity, National Research Center, Dokki, Cairo, Heterocyclic Unit, 1989,

Egypt.

2. Synthesis of some new pyridine derivatives and evaluation of their anticancer

activity, National Research Center, Dokki Cairo, Heterocyclic Unit, 1991,

Egypt.

3. Design and synthesis of combinatorial library of some schiff bases of indolin-

2,3-dione with potential antitubercular activity National Research Center,

Dokki Cairo, Heterocyclic Unit, 1993, Egypt.

4. Preparation and characterization of nano materials inside the nano cages of

zeolite prepared from local materials and their uses as catalysts for synthesis of

pharmaceutical & intermediate organic compounds and removal of wastes

from water, 2005, National Research Centre, Cairo, Egypt.

5. Marine chemistry: Marine natural products as pharmaceutical chemicals, 2007,

International project between NRC, Cairo, Egypt and Istituto per la Chimica di

Molecole di Interesse Biologico del CNR, Napoli, Italy.

6. Bioactive secondary metabolites in benthic invertebrates from Egyptian coasts

from marines, 2005, International project between NRC, Cairo, Egypt and

Istituto per la Chimica di Molecole di Interesse Biologico del CNR, Napoli,

Italy.

Supervision of dissertations (Some Not All):

1. Mohammed Abdel Monhiem, M.Sc. Faculty of Science, Zagazig University,

Egypt. Synthesis and molecular docking of aryl pyrazole derivatives of

expected anti-inflammatory activity.

2. Mohmmod Nabil Yousief , M.Sc. Faculty of Pharmace, Cairo University,

Egypt. Synthesis and Biological studies of Pyrimidines derivatives of expected

analgesic and anti-inflammatory activity.

3. Amin Abou Hashem, Ph.D. Faculty of Science, Cairo University, Egypt.

Synthesis and biological Evaluation of some pyrimidine derivatives of

expected anti-Oxidant and anti-inflammatory activity.

4. Nehal Mohammed Ali , M.Sc. Faculty of Science, Zagazig University, Egypt.

Synthesis and Biological studies of thieno[2,3-d]pyrimidines derivatives of

expected biological activity.

5. Mohammed Abdel Monhiem, M.Sc. Faculty of Science, Zagazig University,

Egypt. Synthesis and molecular docking of aryl pyrazole derivatives of

expected anti-inflammatory activity.

6. Hend N. Hafez, Ph.D. Faculty of Science, Cairo University, Egypt. Synthesis

of some heterocyclic compounds derived from pyridopyrimidines of expected

analgesic and anti-inflammatory activity.

7. Yasmin, Ibraheim Mohammed, M.Sc. Faculty of Science, El-Azhar

University, Egypt. Synthesis and biological Activity of some Nucleosides

Derived from thieno pyrimidines .

8. Shrrein Mohmmod El-Shobaky, M.Sc. Faculty of Science, Cairo University,

Egypt. Synthesis and Biological studies of Pyrimidines Nucleoside Analouges.

9. Mohammed Abdel Monhiem, M.Sc. Faculty of Science, Zagazig University,

Egypt. Synthesis and molecular docking of aryl pyrazole derivatives of

expected anti-inflammatory activity.

10. Auda El-Ghamdy , M.Sc. Faculty of Science, Al-Amier Naif Al-arabia

University, University, Riyadh, King Soudia Arabia. Synthesis and Biological

studies of some nucleosides derived from Pyrimidines of expected analgesic

and anti-inflammatory activity.

Teaching experience:

1. Chemistry courses for undergraduate and graduate students, Chemistry Dep.,

College of Science, Omar El-Mokhtar University, Elbieda, Libia, 2002-2003.

2. Chemistry courses, Science Valley Academy (SVA), El-Ebor City, Cairo,

Egypt, 2007-2009.

3. Chemistry courses for undergraduate students, Physical and Chemistry Dep.,

College of Science, Al-Imam Muhammad Ibn Saud Islamic University,

Riyadh, Saudi Arabia, 2010-2013.

Some Of Training Courses:

1. Training course in the using of microwave reactor, Initiator 2.5, July 2010,

Biotage company, Uppsala, Sweden.

2. Training course in the using of computerized chromatography instrument,

Isolara 4, 18-22 July 2010, Biotage company, Uppsala, Sweden.

3. Training course in Civil Defense, Feb. 2005, NRC, Cairo, Egypt.

4. Training course in Basics of Scientific Writing, Mar. 2005, NRC, Cairo,

Egypt.

5. Training course in Safety and Occupational Health, Mar. 2005, NRC, Cairo,

Egypt.

6. Training course in the industrial production of drugs, Aug. - Dec. 2004. CID

company (Chemical Industries Development), Cairo, Egypt.

Membership:

1. The Saudian Pharmaceutical Society (SPS), Riyadh, Saudi Arabia.

2. The Scientific Committee of Egyptian Second International Conference in

Chemistry: Chemistry for Human Needs, 2009, Hurghada, Egypt.

3. The Excellence Centre, NRC, Cairo, Egypt.

4. The Egyptian Chemical Society (ECS), Academy of Scientific Research and

Technology, Cairo, Egypt.

5. The Egyptian Syndicate of Scientific Profession, Cairo, Egypt.

6. The Society of Researcher Youth in National Research Centre, Cairo, Egypt.

7. The Saudian Chemical Society (SCS), Riyadh, Saudi Arabia.

8. The Amirican Chemical Society (ACS), USA.

9. The Heterocyclic Committee USA.

ISI data (Dec. 2011):

1. A.B.A. El-Gazzar h index = 12; articles = 44; Citation = 275.

2. El-Gazzar, 2010, The highest number of publications in the international

Journals in the field of Pharmaceutical Chemistry., NRC, Cairo, Egypt.

Price (2010)

A.B.A. El-Gazzar

A ward to the national price for the best Researcher in the National Research

Center 2009 - 2010.

Conferences:

1. A.B.A.El-Gazzar, Chemistry of thienopyrimidines fused rings, with a new

ring system. and The 14th Egyptian Chem. Conf. Part 2 (1996).

2. A.B.A.El-Gazzar , A Facile Synthesis of isoxazolo[ 5,4 : 4,5 ] thiasolo [ 3,2 -

a ] thieno pyrimidines -New Ring System, 12th International conference On

Organic Synthesis. Icos -12 (Venezia Lido Iitaly) June 28-July 2-(1998)

3. A.B.A.El-Gazzar, Syntheses and reactions of some poly nuclear thieno[2,3-

d]-pyrimidines derivatives, IUPAC 38th Congress. BRISBANE, Australia, 1-6

July (2001).

4. A.B.A.El-Gazzar, Synthesis of Polyfused Azoles Based On Naphtho[2,1-

e]pyran., The Chem.02 Biannual Conference on Chemistry, Cairo University,

Faculity of Science, Egypt, 4-7 March (2002).

5. A.B.A.El-Gazzar, New And Efficient Synthesis Of C-Nucleosides Derived

From Thienopyrimidines., The 1th Inter-national Conference of Chemical

Industries Research Division National Research Center Egypt, 6-8 December,

(2004).

6. A.B.A. El-Gazzar, Synthesis of new of substituted-6Aminothio-Uraciles

derivatives and their immunomodulatory, anti-inflamatory, and anti-cancer

activities, The 3rd International Conference of the Chemical Industries

Research Division, “Chemical Industries: Role and Future Aspects”, National

Research Centre, 16-18 Dec., Cairo, Egypt, 2008.

7. A.B.A.El-Gazzar, Design and synthesis of 3-Pyrazolyl-thiophene,

Thieno[2,3-d]pyrimidines as New, anti-microbial, anti-inflammatory and

analgesic activities, 23rd European Colloquim on Heterocyclic Chemistry

Antwerp 9-13 Sep. (2008) .

8. A.B.A.El-Gazzar, Studies with Polyfunctionality Substituted Heterocycles:

Novel synthesis of Pyridotriazolopyrimidines., The 10th International

Conference on Chemistry and its Rule in Development ICCRD.10. University

of El-Mansoura, March 16-21 Egypt (2009).

9. A. B. A. El-Gazzar., Design, Synthesis and Pharmacological Evaluation of

New Nonsteroidal Anti-inflammatory Derived from 3-Aminobenzo-

thieno[2,3-d]pyrimidines., 3rd European Conference on Chemistry for life

Science Linking Chemistry with biological Activity Frankfurt am Main

Germany. September 2-5, 2009

10. A. B. A. El-Gazzar., New S-nucleoside Analogues Derived from pyrimidines

As Potential Analgesic and Anti-inflammatory activities. 22nd International

Congress in Heterocyclic Chemistry., Canada, Aug. 02-07, 2009.

11. A.B.A. El-Gazzar, Convenient synthesis and biological activity of some new

Heterocycles containing 1,3-benzothiazole nucleus, The 2nd International

Conference “Chemistry for Human Needs”, 9-12 November, Hurghada,

Egypt, 2009.

List of Publications

1- Reactions of dibenzo[a,d]cyclohepten-5-one with ethyl phosphates and other

selected reactions., F.A.Gad, A.A.Fahmy and A.B.A.El-Gazzar., Phosphorus,

Sulfur and Silicon, Vol. 66, 183-186 (1992).

2- Photochemical behaviour of some dibenzo[a,d]cyclohepten-5-one derivatives.,

F.A.Gad, A.A.Fahmy and A.B.A.El-Gazzar., Egypt. J. Chem., Vol.35, 707-713

(1992).

3- Some reactions of dibenzo[a,d]cyclohepten-5-one derivatives., F.A.Gad,

A.A.Fahmy and A.B.A.El-Gazzar., Egypt. J. Chem., Vol. 35, 611-617 (1992).

4- Chemistry of thienopyrimidines fused rings, with a new ring system.

A.M.Abdel-Fattah, A.S.Aly, and A.B.A.El-Gazzar., The 14th Egyptian Chem.

Conf. Part 2 (1996).

5. A facile synthesis of isooxazolo[5,4:4',5']thiazolo[3,2-a]thienopyrimidines, A

new ring system. A.M.Abdel-Fattah, A.S.Aly, F.A.Gad, M.E.A.Zaki and

A.B.A.El-Gazzar., Phosphorus, Sulfur and Silicon, Vol.141, 263-281 (1998).

6. A Facile Synthesis of isoxazolo[ 5,4 : 4,5 ] thiasolo [ 3,2 - a ] thieno pyrimidines

– New Ring system A.M.Abdel-Fattah, A.S.Aly, F.A.Gad, M.E.A.Zaki and

A.B.A.El-Gazzar 12th International conference On Organic Synthesis. Icos – 12

(Venezia Lido Iitaly) June 28-July 2-(1998)

7. Cycloadditions of 1-aza-2-azoniaallene cations to isothiocyanates., A.B.A.El-

Gazzar, K.Scholten, Y.Guo, K.Weibenbach, M.G.Hitzler, G.Roth, H.Fischer

and J.C.Jochims., J. Chem. Soc. Perkin Trans. 1, 1999-2010 (1999).

8. Aminolysis, Hydrolysis Studies and X-ray structure of 1,2,4-triazole and 1,2,4-

oxadiazole., A.B.A.El-Gazzar, Phosphorus, Sulfur and Silicon,Vol. 152, 83-89

(1999).

9. Synthesis and reaction of polynuclear heterocycles, with a new ring system.

A.M.Abdel-Fattah, A.S.Aly, F.A.Gad, N.A.Hassan and A.B.A.El-Gazzar.,

Phosphorus, Sulfur and Silicon, Vol. 163, 1-27 (2000).

10. Synthesis of polynuclear heterocyclic compounds derived from thieno[2,3-

d]pyrimidines derivatives., A.B.A.El-Gazzar, N.A. Hassan, Molecule, 5, 835

(2000).

11. Synthesis of Some 5H-dibenzo[a,d]cycloheptene derivatives., M.I. Hegab,

A.B.A.El-Gazzar, and F.A.Gad, Egypt. J. Chem. Vol. 44, 355-363 (2001).

12. Syntheses and reactions of some poly nuclear thieno[2,3-d]-pyrimidines

derivatives., A.S.Aly, A.B.A.El-Gazzar, A.E.M.Gaafar and Kh.Abu-Zaid,

IUPAC 38th Congress. BRISBANE, Australia, 1-6 July (2001).

13. Synthesis of some new thiazolo[3,2-a]pyrimido[2,3-d]pyrimi-dinones ans iso-

oxazolo[5,4:4',5']thiazolo[3,2-a]pyrido[2,3-d]pyrimi-dinone., A.B.A.El-

Gazzar, A.M. Gaafar and A.S.Aly., Phosphorus, Sulfur and Silicon, Vol.177,

45 (2002).

14. Studies with polyfunctioality substituted heterocycles: Novel synthesis of

thienopyrimido-1,2,4-triazoles., A.B.A.El-Gazzar, M.I. Hegab, S.A.Swelam

and A.S. Aly., Phosphorus, Sulfur and Silicon, Vol. 177, 123 (2002).

15. Further studies and synthesis of five-membered rings via 1,3-doplar

cycloaddition of 1-aza-2-azoniaalene cations to isothiocyanates and nitriles.,

A.B.A.El-Gazzar, M.I.Hegab, and N.A.Hassan., Sulfur Letters, Vol. 25 (2),

45-62 (2002).

16. Synthesis of 5-chloro-10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5,10-sulfide

and 5,11-dichloro-10,11-dihydro-5H-dibenzo[a,d]-cycloheptene-5,10-sulfide

and their oxidation., M.I.Hegab, A.B.A.El-Gazzar, I.S.Farag and F.A.Gad.,

Sulfur Letters, Vol.25 (2), 79-85 (2002).

17. One pot synthesis of N-nucleosides via 1,3-dipolar cycloaddition of 1-aza-2-

azonia-alene salts to 2,3,4-O-acetyl β-D-glucopyranosyl isothiocyanate.,

A.B.A.El-Gazzar, M.I.Hegab, and N.A.Hassan., Sulfur Letter., Vol.25 (4),

161-171 (2002).

18. Syntheses with Heterocyclic β-Enaminonitriles: A facile synthesis of poly-

functionally substituted pyrimido, pyridino[5',6':4,5]pyrimido and thiazolo, s-

triazolo[4',3'-b]pyrimido[5',6':4,5]pyrimido[1,2-a]-benzimidazole., A.B.A.El-

Gazzar, Egypt. J.Chem. Vol. 45, 995-1016 (2002).

19. Synthesis of Polyfused Azoles Based On Naphtho[2,1-e]pyran., S.A.Swelam

and A.B.A.El-Gazzar, The Chem.02 Biannual Conference on Chemistry, Cairo

University, Faculity of Science, Egypt, 4-7 March (2002).

20. Nitriles In Organic Synthesis: Facile and General Syntheses Of Fused

Tetraaza-Benzo[a]cyclopenta[h]anthracene and Tetraaza-dibenzo-

[a,h]anthracene. S.A. Swelam, M.E.A.Zaki and A.B.A.El-Gazzar., Heterocyclic

Communications, Vol. 9 (2), 143-148 (2003).

21. New And Efficient Synthesis Of C-Nucleosides Derived From

Thienopyrimidines., A.B.A.El-Gazzar, and A.S.Aly, The 1th Inter-national

Conference of Chemical Industries Research Division National Research Center

Egypt, 6-8 December, (2004).

22. Studies with Polyfunctionality Substituted Heterocycles: Novel synthesis of

Pyridotriazolopyrimidines., A.B.A.El-Gazzar, A.E.M. Gaafar, H,N.Hafaz and

A.S. Aly, The 1th International Conference of Chemical Industries Research

Division National Research Center Egypt, 6-8 December, (2004).

23. Novel Synthesis of Some 4,5,6,7-Tetrahydro-Benzo[6,7]cyclohepta-[1,2-

b]pyran, [1,2-b]pyrido[2,3-e]pyrimidines and Thiazolo-pyrido-pyrimidine Via

Cycloaddition with Arylidene malono-nitrile and 6-Aminothiouracil., A.B.A.El-

Gazzar N.Khir El-Din and F.A.Gad., Egypt. J. Chem.47 (1), 63-74 (2004).

24. Regioselective Synthesis of C-Nucleosides Via Condensation of 2-Hydrazino-

thiadiazabenzo[a]azulen-4-one., A.B.A.El-Gazzar., Phosphorus, Sulfur, Silicon,

and the related elements, Vol. 180, 283-293 (2005)

25. Synthesis and Reactions of polynuclear heterocycles: Azolothieno-pyrimidines

and thienothiazolopyrimidines., A.B.A.El-Gazzar, H.A.-R.Hussien, and

A.S.Aly., Phosphorus, Sulfur, Silicon, and the related elements., Vol 181, 2771-

2784 (2006).

26. Novel Synthesis and Reactions of Polynuclear Heterocyclic Derivatives

Derived From Thioxopyridopyrimidines. With a New Ring System. A.B.A.El-

Gazzar, A.M.Gaafar, H.N.Hafez and A.S.Aly., Phosphorus, Sulfur, Silicon, and

the related elements, 181 (8), 1859-1883 (2006).

27. Further Studies and Synthesis of New Pyrido[2,3-d]pyrimidines,

Thiazolopyrido-pyrimidines: The Reaction of 6-Aminothiouracil with Cyclic

,-Unsaturated Ketones., A.B.A.El-Gazzar., Kh.M.Abo-Zeid and

N.A.Hassan., Egypt. J.Chem. 49 (2), 185-207 (2006).

28. New Routes To Pyrano[2,3-d]pyrimidines Derivatives From -Enamino nitrile

and Phosgene Iminium Chloride., N.A.Hassan., Kh.M.Abu-Zeid., A.B.A.El-

Gazzar., Heterocyclic Communications, Vol. 12 (1), 73-78 (2006).

29. Synthesis of some derivatives derived from 1,2,3,4-tetrahydrocyclo-

hepteno[4,5]-thieno[2,3-d]pyrimidine., A.B.A.El-Gazzar, H.A.R. Hussien, and

A.S.Aly., Phosphorus, Sulfur, Silicon, and the related elements Vol 182, 35-56,

(2007).

30. On the chemistry of 5-aryl-2-hydrazino-benzo[6,7]cyclohepta[1,2-b]-

pyrido[2,3-e]-pyrimidin-4-one. A.B.A.El-Gazzar., Kh.M.Abu-Zied, and N.Khir

El-Din., Heteroatom Chemistry, Vol. 18 (1), 34- 43 (2007).

31. Regioselective Synthesis And Reactions Of Polynuclear Heterocyclic Derived

From Pyrido[2,3-d]pyrimidines, With New Ring System., A.B.A.El-Gazzar,

A.M.Gaafar, H.N.Hafez and A.M.Abdel-Fattah., Phosphorus, Sulfur, Silicon,

and the related elements, Vol.182, 386-403 (2007).

32- Synthesis and Reactions Of Some Polynuclear Pyridopyrimidines Derived

From: 6-Aminothiouracil and Arylidene Benzothiazole Derivatives., A.B.A.El-

Gazzar, Egypt. J. Chem. Vol (50), 117 (2007).

33- Synthesis And Anti-Oxidant Activity of Novel Pyrimido[4,5-b]quinolin-4-one

Derivatives. Wth a New Ring System., A.B.A.El-Gazzar, A.M.Gaafar,

M.M.Youssif., A.A.Abu-Hashem and F.A.Badria., Phosphorus, Sulfur, Silicon,

and the related elements, 182, 2009 (2007).

34- One Pot Synthesis Of Pyrido[2,3-d]pyrimidine-2-thione And Studies The

Reactivity Towards Some Reagents., A.B.A.El-Gazzar, H.N.Hafez, and

E.M.A.Yakout., J. of Chin. Chemical. Society , 54, 1303 (2007).

35- Regioselective synthesis and pharmacological activities of Spirodibenzo[a,d]-

cycloheptene-5,2'-[1,3,4]thiadiazole derivatives, M. I. Hegab, A.B.A.El-Gazzar,

M.Ellithey and F.A.Gad., J. of Sulfur Chmistry, 28, 101 (2007).

36- Synthesis and Reactions of Pyrido[2,3-d]pyrimidines With Related Thiazolo

and Enaminonitrile Derivatives, A.B.A.El-Gazzar, H.N.Hafez, A.M.Gaafar and

A.S.Aly., Egypt. J. Of. Chemistry, (Special Issue) (M. Sidky) (6) 79-89 (2007).

37- Syntheses, and biological evalution of thieno[2,3-d]pyrimidines derivatives

anti-inflammatory, analgesic and ulcerogenic activity, A.B.A.El-Gazzar,

H.A.R.Hossein and H.N.Hafez., Acta. Pharm. Vol.57, 395-411 (2007).

38- Synthesis and Reactions of Some Novel Triazolo-, Azolo-, Tetrazolo-pyrido-

pyrimidines and their nucleoside derivatives, Kh.M.Abu-Zeid., A.B.A.El-

Gazzar and N.A.Hassan, J. of Chin. Chemical. Society , 55, 209-217 (2008).

39- Synthesis and Reactions of Some Novel Pyrido[2,3-d]pyrimidines and their

nucleoside derivatives, Kh.M.Abu-Zeid., A.B.A.El-Gazzar and N.A.Hassan, J.

of Trade. Science inc.Vol.4 (3) , (2008).

40- Synthesis and Preliminary Antimicrobial Activity of New Pyrimido[4,5-

b]quinoline, and Pyrido[2,3-d]pyrimidine, A.B.A.El-Gazzar,, H. N. Hafez, M.

E. A. Zaki and A.S. Aly, Phosphorus, Sulfur, Silicon, , 183, 2119-2138, (2008).

41- Design and Synthesis of Azolopyrimidoquinolines, Pyrimidoquinazolines as

Anti-oxidant, Anti-inflammatory and Analgesic Activities, A.B.A.El-Gazzar,

M. M. Youssef, A.M.S.Youssef, A.A. Abu-Hashem and F.A. Badria., European.

Journal of Med. Chem. 44, 609 (2008)..

42- Synthesis and antioxidant, Anti-inflammatory and Analgesic activities of

Novel Polycyclic Pyrimido[4,5-d]pyrimidines, A.B.A. El-Gazzar, H. N. Hafez,

A. A. Abu-Hashem, A. S. Aly Phosphorus, Sulfur, Silicon, 184, 370 (2009).

43- Synthesis, Analgesic, Anti-inflammatory and Antimicrobial activity of Some

Novel Pyrimido[4,5-d]quinolin-4-ones, A.B.A.El-Gazzar, M. A. El-Enany, M.

N. Youssif., Bioorganic and Medicinal Chemistry 16, 3261-3273 (2008).

44- A Simple Synthesis and Antimicrobial Activity of Sulfur-Containing Poly-

condensed Heterocyclic Derived From: 1,3-Benzothiazole, A.B.A.El-Gazzar,

H. N. Hafez. Acta Chim. Slov., 55, 359-371 (2008).

45- Design, Synthesis and Preliminary Evalution as Antimicrobial Activities of

Novel spiro-1,3-Thiazolidine C-acyclic nucleoside analogues, A.B.A.El-

Gazzar, A. M. Gaafar, A. S. Aly, J. of Sulfur Chemistry, 29, 549-559 (2008).

46- New acyclic nucleosides analogues as potential Analgesic, Anti-inflammatory,

Anti-oxidant and Antimicrobial derived from Pyrimido[4,5-b]quinoline,

A.B.A.El-Gazzar, H. N. Hafez, G. A. Nawwar., European. J. Med. Chem. 44,

1427 (2009).

47-Synthesis, Analgesic and Anti-inflammatory activities of Some novel Triazolo

and 2-pyrazolyl-pyrido[2,3-d]pyrimidines. H. N. Hafez, H. A. S. Abbas, A. B.

A. El-Gazzar, Acta Pharma.58, 359 (2008).

48-Acyclic nucleoside analogue, anti-inflammatory, analgesic and anti-microbial

activities A.B.A.El-Gazzar, H. N. Hafez, A. S. Aly., 23rd European Colloquim

on Heterocyclic Chemistry Antwerp 9-13 Sep. (2008) Acceptance 19- Mar.

2008.

49-Design and synthesis of 3-Pyrazolyl-thiophene, Thieno[2,3-d]pyrimidines as

New, anti-microbial, anti-inflammatory and analgesic activities A.B.A.El-

Gazzar, H. N. Hafez,, 23rd European Colloquim on Heterocyclic Chemistry

Antwerp 9-13 Sep. (2008) Acceptance 19- Mar. 2008.

50- A Facile Regioselective synthesis of Novel spiro-thioxanthene and spiro-

xanthene-9’,2-[1,3,4]thiadiazole derivatives as potential analgesic and anti-

inflammatory agents., H. N. Hafez, M. I. Hegab, I. S. Ahmed-Farag A.B.A.El-

Gazzar,., Bioog Med. Chem., 18, 4538-4543 (2008).

51- Acyclic and N-Nuclesides analogue, anti-HIV activity A.B.A.El-Gazzar, H.

N. Hafez, H. S. Abbas., in press (2008).

52- C- and S- Nucleosidoquinazoline. As New Nucleoside Analogs With Potential

Analgesic and Anti-inflammatory Activity., Abdel-Rahman B. A. El-Gazzar,

Hend N. Hafez and Hebat-Allah S. Abbas., Bioog. Med. Chem.44, 4249

(2009).

53- Synthesis, Antitumor and Analgesic Activity of Substituted Triazolo[4,3-b]-

pyrimidines With an Incorporated Thiazolidinone Moiety., Abdel-Rahman B.

A. El-Gazzar, Hend N. Hafez,m Bioog., Med. Chem. 19, 4143 (2009).

54- Studies with Polyfunctionality Substituted Heterocycles: Novel synthesis of

Pyridotriazolopyrimidines., H. N. Hafez., A.B.A.El-Gazzar, H,N.Hafaz The 10th

International Conference on Chemistry and its Rule in Development ICCRD.10.

University of El-Mansoura, March 16-21 Egypt (2009).

55. Synthesis and antitumor activity of substituted triazolo[4,3-a]pyrimidin-6-

sulfonamide with an incorporated thiazolidinone moiety., Hend N. Hafez and

Abdel-Rahman B. A. El-Gazzar, Bioorg. Med. Chem. Lett. 19, 4143 (2009)

56. Synthesis of new 4-substituted pyrido[2,3-d]pyrimidin-4(1H)-ones and their

evaluation for anti-inflammatory and analgesic activities, Hend N. Hafez and

Abdel-Rahman B. A. El-Gazzar, Bioorg. Med. Chem. Lett. 19, 3392 (2009)

57. S- and C-Nucleosidoquinazoline as new nucleoside analogs with potential

analgesic and anti-inflammatory activity., Abdel-Rahman B. A. El-Gazzar*,

Hend N. Hafez and Hebat-Allah S. Abbas., Eur. Med. Chem. (2009).

58. Synthesis, Biological and Medicinal Significance of S-glycosido-thieno[2,3-

d]pyrimidines as New Anti-inflammatory and Analgesic Agents., Hend. N.

Hafez Abdel-Rahman B. A. El-Gazzar and Galal. A. M. Nawwar., Euro.J.

Med. Chem 45, (2009).

59. New S-nucleoside Analogues Derived from Thieno[2,3-d]pyrimidines As

Potential Analgesic and Anti-inflammatory activities., A.B.A. El-Gazzar*a,

H. N. Hafeza, G.A.M. Nawwarb 3rd European Conference on Chemistry for

life Science Linking Chemistry with biological Activity Frankfurt am Main

Germany. September 2-5, 2009

60. Design, Synthesis and Pharmacological Evaluation of New Nonsteroidal Anti-

inflammatory Derived from 3-Aminobenzo-thieno[2,3-d]pyrimidines., H. N.

Hafez and A. B. A. El-Gazzar., 3rd European Conference on Chemistry for

life Science Linking Chemistry with biological Activity Frankfurt am Main

Germany. September 2-5, 2009

61- New S-nucleoside Analogues derived from pyrimidines As Potential Analgesic

and Anti-inflammatory activities. H. N. Hafez and A. B. A. El-Gazzar., 22nd

International Congress in Heterocyclic Chemistry., Canada, Aug. 02-07, 2009.

62. Design, Synthesis and Pharmacological Evaluation of New Nonsteroidal Anti-

inflammatory Derived from 3-Aminobenzo-thieno[2,3-d]pyrimidines., H. N.

Hafez and A. B. A. El-Gazzar., 22nd International Congress in Heterocyclic

Chemistry., Canada, Aug. 02-07, 2009.

63- Antitumor Activity of New Substituted Pyrimido benzothiopyrane and its

Glycosides : Selectivity against Colon Tumor Cells and Effect on Cell Cycle-

Relaterd Events., A. B. A. El-Gazzar., H. N. Hafez., A.S.Aly, The 18th

Egyptain Chemical Conference, Chemistry For Human Needs. (9-12 November

2009).

64. Design, Synthesis of Substituted Thieno[2,3-d]pyrimidine-2,4-dithiones and

its S-glycosides Analogues as Potential Antiviral and Antibacterial Agents.,

Hend N. Hafez, Hoda A. R. Hussein and Abdel-Rahman B. A. El-Gazzar.,

Arch der Pharmazie (2009).

65- Hend. N. Hafez., Abdel-Rahman B. A. El-Gazzar and Galal. A. M. Nawwar.,

Synthesis, Biological and Medicinal Significance of S-glycosido-thieno[2,3-

d]-pyrimidines as New Anti-inflammatory and Analgesic Agents., Euro.J.

Med. Chem 45, 1485-1493 (2010).

66- Hend N. Hafez, Hoda A. R. Hussein and Abdel-Rahman B. A. El-

Gazzar*.,Design, Synthesis of Substituted Thieno[2,3-d]pyrimidine-2,4-

dithiones and its S-glycosides Analogues as Potential Antiviral and

Antibacterial Agents., European Journal of Medicinal Chemistry ., 45, 4026-

4034 (2010).

67- Mohammed M. Babatin, Madhat M. Said, Hend N. Hafez, Abdel-Rahman B.

A. El-Gazzar, Novel anti-inflammatory and analgesic agents of 5-chromeno-

pyrido[2,3-d]pyrimidine-4-yl derivatives and S-nucleosides analogous .,

International Journal of Pharmaceutical Sciences Review and Research

Volume 4, Issue 2, September 2010.

68- M. M. Babatin, A. B. A. El-Gazzar and H. N. Hafez, Simple and efficient

synthesis of novel glycosyl thiourea derivatives derived from Thiophene as

potential antitumor agents., Journal of Chemistry and Chemical Engineering

5, 2010, 74-82.

69- Hebat-Allah S. Abbas, Hend N. Hafez, Abdel-Rahman B. A. El-Gazzar,

Synthesis, in vitro antimicrobial and in vivo antitumor evaluation of novel

pyrimidoquinolines and its nucleoside derivatives. European Journal of

Medicinal Chemistry, 45 (2011) 21-30.

70. Design, Synthesis and Pharmacological Evaluation of New Nonsteroidal Anti-

Inflammatory Derived from 3-Aminobenzothieno[2,3-d]pyrimidines., Hend

Nagah Hafez, Omar Khalid Al-Duaij, Abdel-Rhman Barakat A. El-Gazzar,

International Journal of Organic Chemistry, (2013) 3, 110-118.

71. Synthesis of novel series of benzothieno[2,3-d]pyrimidine derivatives,

promising anticancer agents., Hend N. Hafez, Omar K. Al-Duaij and Abdel-

Rhman B. A. El-Gazzar., Journal of Chemistry and Chemical Engineering 7,

2013, 199-208.

72. Efficient Synthesis of noval spiro[3,2-d]pyrimidine as potanet antimicrobial

and antioxidant activities. Hend N. Hafez and Abdel-Rhman B. A. El-Gazzar

(2013).

73. Synthesis of Novel Bioactive Derivatives of 3-Cyclohexyl-2-thioxo-5,6,7,8-

tetrahydrobenzo(b)thieno[2,3-d]pyrimidine-4(3H)-one., Hend. N. Hafez, Abdel-

Rhman Al-Shamary and Abdel-Rhman B. A. El-Gazzar., (2013).

74. Facile heterocyclic synthesis and antimicrobial activity of polysubstituted and

condensed pyrazolopyranopyrimidine and pyrazolopyranotriazine derivatives,

Hend N. Hafez, Abdulrah man G. Alsha mmari, Abdel-Rh man B. A. El-

Gazzar, Acta Pharm. 65 (2015) 399–412.

75. Synthesis of pyranopyrazolo N-glycoside and pyrazolopyranopyrimidine C-

glycoside derivatives as promising antitumor and antimicrobial agents, HEND

N. HAFEZ, ABDEL-RHMAN B. A. EL-GAZZAR, Acta Pharm. 65 (2015)

215–233.

76. Novel pyrazole derivatives with oxa/thiadiazolyl, pyrazolyl moieties and

pyrazolo[4,3-d]-pyrimidine derivatives as potential antimicrobial and

anticancer agents, Hend N. Hafez , Abdel-Rhman B. A. El-Gazzar , Sami A.

Al-Hussain Bioorganic & Medicinal Chemistry Letters, 26 (2016) 2428–2433.

77. Simple approach to thieno[3,2-d]pyrimidines as new scaffolds of antimicrobial

activities, HEND N. HAFEZ ABDEL-RHMAN B. A. EL-GAZZAR, MAGDI

E. A. ZAKI, Acta Pharm. 66 (2016) 331–351.

78. Synthesis and Biological Evaluation of N- Pyrazolyl Derivatives and

Pyrazolo-pyrimidine Bearing a Biologically Active Sulfonamide Moiety as

Potential Anti-microbial Agent. Hend N. Hafez, Abdel-Rhman B.A. El-

Gazzar, Molecules 2016, 21, 1156.

79. One-Pot Microwave Synthesis of Pyrimido[4,5-b]quinoline and its C- and S-

Glycosides with Anti-Inflammatory and Anticancer Activities. Hend N. Hafez,

Sami A. Al-Hussain, Abdel-Rhman B. A. El-Gazzar, Croat. Chem. Acta 2016,

89 (3).

80. A Simple Precursor for Highly Functionalized Fused Imidazo[4,5-b]pyridines

and Imidazo[4,5-b]-1,8-naphthyridine,. Omar K. Al-duaij, Magdi E. A. Zaki

and Abdel-Rhman B. A. El-Gazzar., Molecules 2016, 21(12), 1646;

doi:10.3390/ molecules 21121646.

81. Efficient Synthesis of noval spiro[3,2-d]pyrimidine as potanet antimicrobial

and antioxidant activities. Hend N. Hafez and Abdel-Rhman B. A. El-Gazzar (

in press 2017).

82. Synthesis of Novel Bioactive Derivatives of 3-Cyclohexyl-2-thioxo-5,6,7,8-

tetrahydrobenzo(b)thieno[2,3-d]pyrimidine-4(3H)-one., Hend. N. Hafez, and

Abdel-Rhman B. A. El-Gazzar., (in press 2017).

83. Novel synthesis approach and antiplatelet activity evaluation of 6-

arylmethyleneamino-2-alkylsulfonylpyrimidin-4(3H)-one derivatives and its

nucleosides., Abdel-Rhman B. A. El-Gazzar., International Journal of Organic

Chemistry, in press (2017)

84. Practical and efficient synthesis of a new class of N-Nucleosides of 4H-

benzothiopyran[2,3-d]pyrimidine-10-sulfone as potential anticancer and

antibacterial agents., Abdel-Rhman B. A. El-Gazzar and Hend N Hafez,

International Journal of Organic Chemistry, in press (2017)

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