contact

Prof. Burkhard Ludewig

titel Prof. Dr.

first name Burkhard

last name Ludewig

street Rorschacherstrasse 95

city 9007 St. Gallen

country Switzerland

phone number +41-71-494 1090

fax +41-71-494 6321

e-mail burkhard.ludewig@kssg.ch

homepage www.kssg.ch/mfz/institut-fuer-immunbiologie

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research profile

academic status Leitende(r) Wissenschaftler/in

department Interdisziplinäre Medizinische Dienste

faculty Institut für Immunbiologie

position Head, Institute of ImmunobiologyHead, Medical Research Center

fields of research Immunology, Virology, Stromal Cell Biology,Mathematical Modelling

former positions 1995-1996 Postdoctoral fellow at the Departmentof Molecular Immunology, Robert Koch-Institute,Berlin.1996 Postdoctoral fellow at the Department ofMolecular Virology, Hebrew University, Jerusalem,Israel.1997-1999 Postdoctoral fellow at the Institute ofExperimental Immunology, University of Zürich,Switzerland.1999-2002 Senior research fellow at the Instituteof Experimental Immunology, University of Zürich,Switzerland.2001-2008 Co-founder and scientific advisor,Ganymed Pharmaceuticals AG, Mainz, Germany2008 Appointment as Full Professor (W3) forExperimental Immunology at the Helmholtz Centrefor Infection Research (Braunschweig) and theMedical School Hannover (declined)2002-present Head, Institute of Immunobiology,Kantonal Hospital St. Gallen, Switzerland2009-present Head, Medical Research Center,Kantonal Hospital St. Gallen, Switzerland

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research profile

affiliations Swiss Society of Allergology and Immunology(SSAI)German Society of Immunology (DGfI)American Society of Immunology (AAI)

awards 1993-1994 NaFöG-fellowship of the Senate ofBerlin1996 Golda Meir Postdoctoral Research Fellowshipof the Hebrew University of Jerusalem1996 Wood-Whelan Research Fellowship of theInternational Union of Biochemistry and MolecularBiology1997-1999 Postdoctoral Fellowship of the DeutscheForschungsgemeinschaft

patents Sahin, U., O. Türeci, und B. Ludewig. Verfahren zurIdentifizierung biologisch aktiver Strukturenmikrobieller Erreger (MicroGATE). No. 101 08626.1, February 22, 2001.

additional information Citations in Google Scholar:http://scholar.google.ch/scholar?q=author:ludewig+author:burkhard&hl=de&as_sdt=0,5

Publications in PubMed:https://www.ncbi.nlm.nih.gov/pubmed/?term=ludewig+b+NOT+(Ludewig+Bernd+OR+Ludewig+Britta)

SUPERVISION OF GRADUATE STUDENTS ANDPOSTDOCTORAL FELLOWS1999 – 2002 1 PhD student, 4 MSc students

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research profile

Institute of Experimental Immunology, University ofZurich, Switzerland2002 – 2017 15 PhD students, 12 MScstudents, 22 postdoctoral fellowsUniversity of Zurich and ETH Zurich, Switzerland;UNAM, Mexico City, Mexico

TEACHING ACTIVITIES2001 – 2008 Privatdozent (lecturer) –Immunopathology, Veterinary Faculty, University ofZurich, Switzerland2008 – 2014 Titularprofessor (lecturer) –Immunopathology, Veterinary Faculty, University ofZurich, Switzerland2014 – present Titularprofessor (lecturer) –Immunology, Science Faculty, University of Zurich,Switzerland2016 – present Dozent (external lecturer) –Immunology, Department of Biology, ETH Zurich,Switzerland ORGANISATION OF SCIENTIFIC MEETINGS2003 Joint Annual Meeting of the SwissSociety of Allergology and Immunology and theSwiss Society of Pneumology, St. Gallen,Switzerland2010 Annual Meeting of the Swiss Society ofAllergology and Immunology on TranslationalImmunology, St. Gallen, Switzerland,2010 Member of the Organizing Committee atthe 11th International Symposium on DendriticCells in Fundamental and Clinical Immunology - DC

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research profile

2010, Lugano, Switzerland2016 Co-organizer of the first KeystoneSymposium on “Stromal Cells in Immunity”,Keystone, USA2017 Joint Annual Meeting of the SwissSociety of Allergology and Immunology and theSwiss Society of Pediatrics, St. Gallen, Switzerland2017 4th Lymphoid Tissue Meeting “Focus on:Stromal Cells”, St. Gallen, Switzerland2018 Member of the Scientific ProgramCommittee of the 5th European Congress ofImmunology, Amsterdam, The Netherlands

INSTITUTIONAL RESPONSIBILITIES2002 – present Veterinary officer of theMedical Research Center, Kantonsspital St.Gallen2002 – 2012 Biosafety officer of the MedicalResearch Center, Kantonsspital St.Gallen

COMMISSIONS OF TRUST2002 – 2008 Co-founder and scientific advisor,Ganymed Pharmaceutical AG, Mainz, Germany2008 Appointment as Full Professor (W3) forExperimental Immunology at the Helmholtz Centrefor Infection Research (Braunschweig) and theMedical School Hannover (declined)2008 – present Member, executive board ofthe Swiss Clinical Trials Organization, the centralcooperation platform for patient-oriented, clinicalresearch in Switzerland2010 – present Member and treasurer (since2014), executive board of Swiss Society of

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Allergology and Immunology2010 Member of the Editorial Board of theEuropean Journal of Immunology2013 Member of the Editorial Board of theJournal of Immunology2016 – present Member of Evaluation Panels“Ambizione&Prima” of the Swiss National ScienceFoundation2016 Member of Evaluation Panel “Infectionand Immunity”, Agence Nationale de la Recherche,France

7

publications

title

journalpaper/review

Perkey E, Maurice De Sousa D, Carrington L, Chung J, Dils A, GranadierD, Koch U, Radtke F, Ludewig B, Blazar B R, Siebel C W, Brennan T V,Nolz J, Labrecque N, Maillard I. GCNT1-Mediated -Glycosylation of theSialomucin CD43 Is a Sensitive Indicator of Notch Signaling in ActivatedT Cells. J Immunol 2020; 204:1674-1688.

Dasoveanu D C, Park H J, Ly C L, Shipman W D, Chyou S, Kumar V,Tarlinton D, Ludewig B, Mehrara B J, Lu T T. Lymph node stromal CCL2limits antibody responses. Sci Immunol 2020; 5:.

Cosgrove J, Novkovic M, Albrecht S, Pikor N, Zhou Z, Onder L, Mörbe U,Cupovic J, Miller H, Alden K, Thuery A, O'Toole P, Pinter R, Jarrett S,Taylor E, Venetz D, Heller M, Uguccioni M, Legler D F, Lacey C J,Coatesworth A, Polak W G, Cupedo T, Manoury B, Thelen M, Stein J V,Wolf M, Leake M C, Timmis J, Ludewig B, Coles M C. B cell zone reticularcell microenvironments shape CXCL13 gradient formation. Nat Commun2020; 11:3677.

Bocharov G, Volpert V, Ludewig B, Meyerhans A. Editorial: MathematicalModeling of the Immune System in Homeostasis, Infection and Disease.Front Immunol 2020; 10:2944.

Chauveau A, Pirgova G, Cheng H W, De Martin A, Zhou F Y, Wideman S,Rittscher J, Ludewig B, Arnon T I. Visualization of T Cell Migration in theSpleen Reveals a Network of Perivascular Pathways that Guide Entry intoT Zones. Immunity 2020;.

Pikor N, Mörbe U, Lütge M, Gil Cruz C, Perez Shibayama C, Novkovic M,Cheng H W, Nombela-Arrieta C, Nagasawa T, Linterman M A, Onder L,Ludewig B. Remodeling of light and dark zone follicular dendritic cellsgoverns germinal center responses. Nat Immunol 2020; 21:649-659.

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title

journalpaper/review

Novkovic M, Onder L, Bocharov G, Ludewig B. Topological Structure andRobustness of the Lymph Node Conduit System. Cell Rep 2020;30:893-904.e6.

Choi S Y, Bae H, Jeong S H, Park I, Cho H, Hong S P, Lee D H, Lee C K,Park J S, Suh S H, Choi J, Yang M J, Jang J Y, Onder L, Moon J H, Jeong HS, Adams R H, Kim J M, Ludewig B, Song J H, Lim D S, Koh G Y. YAP/TAZdirect commitment and maturation of lymph node fibroblastic reticularcells. Nat Commun 2020; 11:519.

Ludewig B. Rolf Zinkernagel and the co-discovery of MHC restrictiontogether with Peter Doherty. Allergy 2019;.

Colston J M, Hutchings C, Chinnakannan S, Highton A, Perez ShibayamaC, Ludewig B, Klenerman P. Divergent memory responses driven byadenoviral vectors are impacted by epitope competition. Eur J Immunol2019;.

Cheng H W, Onder L, Novkovic M, Soneson C, Lütge M, Pikor N, ScandellaE, Robinson M D, Miyazaki J I, Tersteegen A, Sorg U, Pfeffer K, Rülicke T,Hehlgans T, Ludewig B. Origin and differentiation trajectories offibroblastic reticular cells in the splenic white pulp. Nat Commun 2019;10:1739.

Denton A E, Innocentin S, Carr E J, Bradford B M, Lafouresse F, MabbottN A, Mörbe U, Ludewig B, Groom J R, Good-Jacobson K L, Linterman M A.Type I interferon induces CXCL13 to support ectopic germinal centerformation. J Exp Med 2019;.

Camara A, Cordeiro O G, Alloush F, Sponsel J, Chypre M, Onder L, AsanoK, Tanaka M, Yagita H, Ludewig B, Flacher V, Mueller C G. Lymph NodeMesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage Niche.Immunity 2019; 50:1467-1481.e6.

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Perez Shibayama C, Gil Cruz C, Ludewig B. Fibroblastic reticular cells atthe nexus of innate and adaptive immune responses. Immunol Rev 2019;289:31-41.

Fässler M, Diem S, Mangana J, Hasan Ali O, Berner F, Bomze D, Ring S,Niederer R, Gil Cruz C, Perez Shibayama C, Krolik M, Siano M, Joerger M,Recher M, Risch L, Güsewell S, Risch M, Speiser D E, Ludewig B,Levesque M P, Dummer R, Flatz L. Antibodies as biomarker candidates forresponse and survival to checkpoint inhibitors in melanoma patients. JImmunother Cancer 2019; 7:50.

Solmaz G, Puttur F, Francozo M, Lindenberg M, Guderian M, Swallow M,Duhan V, Khairnar V, Kalinke U, Ludewig B, Clausen B E, Wagner H, LangK S, Sparwasser T D. TLR7 Controls VSV Replication in CD169 SCSMacrophages and Associated Viral Neuroinvasion. Front Immunol 2019;10:466.

Zarak-Crnkovic M, Kania G, Jaźwa-Kusior A, Czepiel M, Wijnen W J, CzyżJ, Müller-Edenborn B, Vdovenko D, Lindner D, Gil Cruz C, Bachmann M,Westermann D, Ludewig B, Distler O, Lüscher T F, Klingel K, Eriksson U,Błyszczuk P. Heart non-specific effector CD4 T cells protect frompostinflammatory fibrosis and cardiac dysfunction in experimentalautoimmune myocarditis. Basic Res Cardiol 2019; 115:6.

Lercher A, Bhattacharya A, Popa A M, Caldera M, Schlapansky M F,Baazim H, Agerer B, Gürtl B, Kosack L, Májek P, Brunner J S, Vitko D,Pinter T, Genger J W, Orlova A, Pikor N, Reil D, Ozsvár-Kozma M, KalinkeU, Ludewig B, Moriggl R, Bennett K L, Menche J, Cheng P N, SchabbauerG, Trauner M, Klavins K, Bergthaler A. Type I Interferon SignalingDisrupts the Hepatic Urea Cycle and Alters Systemic Metabolism toSuppress T Cell Function. Immunity 2019; 51:1074-1087.e9.

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journalpaper/review

Argilaguet J, Pedragosa M, Esteve-Codina A, Riera G, Vidal E, Gil Cruz C,Casella V, Andreu D, Kaisho T, Bocharov G, Ludewig B, Heath S,Meyerhans A. Systems analysis reveals complex biological processesduring virus infection fate decisions. Genome Res 2019; 29:907-919.

Gil Cruz C, Perez Shibayama C, De Martin A, Ronchi F, van der Borght K,Niederer R, Onder L, Lütge M, Novkovic M, Nindl V, Ramos G, Arnoldini M,Slack E M C, Boivin-Jahns V, Jahns R, Wyss M, Mooser C, Lambrecht B N,Maeder M T, Rickli H, Flatz L, Eriksson U, Geuking M B, McCoy K D,Ludewig B. Microbiota-derived peptide mimics drive lethal inflammatorycardiomyopathy. Science 2019; 366:881-886.

Li C, Lam E, Perez Shibayama C, Ward L A, Zhang J, Lee D, Nguyen A,Ahmed M, Brownlie E, Korneev K V, Rojas O, Sun T, Navarre W, He H H,Liao S, Martin A, Ludewig B, Gommerman J L. Early-life programming ofmesenteric lymph node stromal cell identity by the lymphotoxin pathwayregulates adult mucosal immunity. Sci Immunol 2019; 4:.

Dubey L K, Ludewig B, Luther S A, Harris N L. IL-4Rα-Expressing B CellsAre Required for CXCL13 Production by Fibroblastic Reticular Cells. CellRep 2019; 27:2442-2458.e5.

Brenig R, Pop O, Triantafyllou E, Geng A, Singanayagam A, PerezShibayama C, Besse L, Cupovic J, Künzler-Heule P, Boldanova T, Brand S,Semela D, Duong F H, Weston C J, Ludewig B, Heim M H, Wendon J,Antoniades C G, Bernsmeier C. Expression of AXL receptor tyrosinekinase relates to monocyte dysfunction and severity of cirrhosis. Life SciAlliance 2019; 3:.

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Rieckmann M, Delgobo M, Gaal C, Büchner L, Steinau P, Reshef D, GilCruz C, Ter Horst E N, Kircher M, Reiter T, Heinze K G, Niessen H W,Krijnen P A, van der Laan A M, Piek J J, Koch C, Wester H J, Lapa C,Bauer W R, Ludewig B, Friedman N, Frantz S, Hofmann U, Ramos G C.Myocardial infarction triggers cardioprotective antigen-specific T helpercell responses. J Clin Invest 2019; 130:.

Baumann N S, Torti N, Welten S P M, Barnstorf I, Borsa M, Pallmer K,Oduro J D, Cicin-Sain L, Ikuta K, Ludewig B, Oxenius A. Tissuemaintenance of CMV-specific inflationary memory T cells by IL-15. PLoSPathog 2018; 14:e1006993.

Perez Shibayama C, Gil Cruz C, Cheng H W, Onder L, Printz A, Mörbe U,Novkovic M, Li C, Lopez-Macias C, Buechler M B, Turley S J, Mack M,Soneson C, Robinson M D, Scandella E, Gommerman J, Ludewig B.Fibroblastic reticular cells initiate immune responses in visceral adiposetissues and secure peritoneal immunity. Sci Immunol 2018; 3:.

Cheng H W, Onder L, Cupovic J, Bösch M, Novkovic M, Pikor N, TarantinoI, Rodriguez R, Schneider T, Jochum W, Brutsche M, Ludewig B. CCL19-producing fibroblastic stromal cells restrain lung carcinoma growth bypromoting local antitumor T-cell responses. J Allergy Clin Immunol 2018;.

Takeuchi A, Ozawa M, Kanda Y, Kozai M, Ohigashi I, Kurosawa Y, RahmanM A, Kawamura T, Shichida Y, Umemoto E, Miyasaka M, Ludewig B,Takahama Y, Nagasawa T, Katakai T. A Distinct Subset of FibroblasticStromal Cells Constitutes the Cortex-Medulla Boundary Subcompartmentof the Lymph Node. Front Immunol 2018; 9:2196.

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journalpaper/review

Emgård J, Kammoun H, García-Cassani B, Chesné J, Parigi S M, Jacob JM, Cheng H W, Evren E, Das S, Czarnewski P, Sleiers N, Melo-Gonzalez F,Kvedaraite E, Svensson M, Scandella E, Hepworth M R, Huber S, LudewigB, Peduto L, Villablanca E J, Veiga-Fernandes H, Pereira J P, Flavell R A,Willinger T. Oxysterol Sensing through the Receptor GPR183 Promotesthe Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells andColonic Inflammation. Immunity 2018; 48:120-132.e8.

Van der Borght K, Scott C L, Martens L, Sichien D, Van Isterdael G, NindlV, Saeys Y, Boon L, Ludewig B, Gillebert T C, Lambrecht B N. MyocarditisElicits Dendritic Cell and Monocyte Infiltration in the Heart and Self-Antigen Presentation by Conventional Type 2 Dendritic Cells. FrontImmunol 2018; 9:2714.

Onder L, Ludewig B. A Fresh View on Lymph Node Organogenesis. TrendsImmunol 2018; 39:775-787.

Onder L, Ludewig B. Redefining the Nature of Lymphoid Tissue OrganizerCells: Response to 'Complexity of Lymphoid Tissue Organizers' by Koningand Mebius. Trends Immunol 2018; 39:952-953.

Bösch M, Onder L, Cheng H W, Novkovic M, Mörbe U, Sopper S, Gastl G,Jochum W, Ruhstaller T, Knauer M, Ludewig B. Interleukin 7-expressingfibroblasts promote breast cancer growth through sustenance of tumorcell stemness. Oncoimmunology 2018; 7:e1414129.

Bogdanova D, Takeuchi A, Ozawa M, Kanda Y, Rahman M A, Ludewig B,Kinashi T, Katakai T. Essential Role of Canonical NF-κB Activity in theDevelopment of Stromal Cell Subsets in Secondary Lymphoid Organs. JImmunol 2018; 201:3580-3586.

Novkovic M, Onder L, Cheng H W, Bocharov G, Ludewig B. IntegrativeComputational Modeling of the Lymph Node Stromal Cell Landscape.Front Immunol 2018; 9:2428.

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journalpaper/review

Dubey L K, Karempudi P, Luther S A, Ludewig B, Harris N L. Interactionsbetween fibroblastic reticular cells and B cells promote mesenteric lymphnode lymphangiogenesis. Nat Commun 2017; 8:367.

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journalpaper/review

Cossarizza A, Chang H D, Radbruch A, Andrä I, Annunziato F, Bacher P,Barnaba V, Battistini L, Bauer W M, Baumgart S, Becher B, Beisker W,Berek C, Blanco A, Borsellino G, Boulais P E, Brinkman R R, Büscher M,Busch D H, Bushnell T P, Cao X, Cavani A, Chattopadhyay P K, Cheng Q,Chow S, Clerici M, Cooke A, Cosma A, Cosmi L, Cumano A, Dang V D,Davies D, De Biasi S, Del Zotto G, Della Bella S, Dellabona P, Deniz G,Dessing M, Diefenbach A, Di Santo J, Dieli F, Dolf A, Donnenberg V S,Dörner T, Ehrhardt G R A, Endl E, Engel P, Engelhardt B, Esser C, EvertsB, Falk C S, Fehniger T A, Filby A, Fillatreau S, Follo M, Förster I, Foster J,Foulds G A, Frenette P S, Galbraith D, Garbi N, García-Godoy M D,Ghoreschi K, Gibellini L, Goettlinger C, Goodyear C S, Gori A, Grogan J,Gross M, Grützkau A, Grummitt D, Hahn J, Hammer Q, Hauser A E,Haviland D L, Hedley D, Herrera G, Herrmann M, Hiepe F, Holland T,Hombrink P, Houston J P, Hoyer B F, Huang B, Hunter C A, Iannone A,Jäck H M, Jávega B, Jonjic S, Juelke K, Jung S, Kaiser T, Kalina T, KellerB, Khan S, Kienhöfer D, Kroneis T, Kunkel D, Kurts C, Kvistborg P,Lannigan J, Lantz O, Larbi A, LeibundGut-Landmann S, Leipold M D,Levings M K, Litwin V, Liu Y, Lohoff M, Lombardi G, Lopez L, Lovett-RackeA, Lubberts E, Ludewig B, Lugli E, Maecker H T, Martrus G, Matarese G,Maueröder C, McGrath M, McInnes I, Mei H E, Melchers F, Melzer S,Mielenz D, Mills K, Mjösberg J, Moore J, Moran B, Moretta A, Moretta L,Mosmann T R, Müller S, Müller W, Münz C, Multhoff G, Munoz L E, MurphyK M, Nakayama T, Nasi M, Neudörfl C, Nolan J, Nourshargh S, O'Connor JE, Ouyang W, Oxenius A, Palankar R, Panse I, Peterson P, Peth C, Petriz J,Philips D, Pickl W, Piconese S, Pinti M, Pockley A G, Podolska M J, PucilloC, Quataert S A, Radstake T R D J, Rajwa B, Rebhahn J A, RecktenwaldD, Remmerswaal E B M, Rezvani K, Rico L G, Robinson J P, Romagnani C,Rubartelli A, Ruland J, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y,Sanderson S, Sawitzki B, Scheffold A, Schiemann M, Schildberg F,Schimisky E, Schmid S A, Schmitt S, Schober K, Schüler T, Schulz A R,

15

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journalpaper/review

Carreño J M, Perez Shibayama C, Gil Cruz C, López-Macías C, Vernazza P,Ludewig B, Albrich W. Evolution of Salmonella Typhi outer membraneprotein-specific T and B cell responses in humans following oral Ty21avaccination: A randomized clinical trial. PLoS ONE 2017; 12:e0178669.

Van der Borght K, Scott C L, Nindl V, Bouché A, Martens L, Sichien D, VanMoorleghem J, Vanheerswynghels M, De Prijck S, Saeys Y, Ludewig B,Gillebert T, Guilliams M, Carmeliet P, Lambrecht B N. MyocardialInfarction Primes Autoreactive T Cells through Activation of DendriticCells. Cell Rep 2017; 18:3005-3017.

Onder L, Mörbe U, Pikor N, Novkovic M, Cheng H W, Hehlgans T, PfefferK, Becher B, Waisman A, Rülicke T, Gommerman J, Mueller C G, Sawa S,Scandella E, Ludewig B. Lymphatic Endothelial Cells Control Initiation ofLymph Node Organogenesis. Immunity 2017; 47:80-92.e4.

Kindler E, Gil Cruz C, Spanier J, Li Y, Wilhelm J, Rabouw H H, Züst R,Hwang M, V'kovski P, Stalder H, Marti S, Habjan M, Cervantes-BarraganL, Elliot R, Karl N, Gaughan C, van Kuppeveld F J M, Silverman R H, KellerM, Ludewig B, Bergmann C C, Ziebuhr J, Weiss S R, Kalinke U, Thiel V.Early endonuclease-mediated evasion of RNA sensing ensures efficientcoronavirus replication. PLoS Pathog 2017; 13:e1006195.

Chung J, Ebens C L, Perkey E, Radojcic V, Koch U, Scarpellino L, Tong A,Allen F, Wood S, Feng J, Friedman A, Granadier D, Tran I T, Chai Q, OnderL, Yan M, Reddy P, Blazar B R, Huang A Y, Brennan T V, Bishop D K,Ludewig B, Siebel C W, Radtke F, Luther S A, Maillard I. Fibroblasticniches prime T cell alloimmunity through Delta-like Notch ligands. J ClinInvest 2017; 127:1574-1588.

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journalpaper/review

Pikor N, Cupovic J, Onder L, Gommerman J L, Ludewig B. Stromal CellNiches in the Inflamed Central Nervous System. J Immunol 2017;198:1775-1781.

Novkovic M, Onder L, Bocharov G, Ludewig B. Graph Theory-BasedAnalysis of the Lymph Node Fibroblastic Reticular Cell Network. MethodsMol Biol 2017; 1591:43-57.

Takeda A, Kobayashi D, Aoi K, Sasaki N, Sugiura Y, Igarashi H, Tohya K,Inoue A, Hata E, Akahoshi N, Hayasaka H, Kikuta J, Scandella E, LudewigB, Ishii S, Aoki J, Suematsu M, Ishii M, Takeda K, Jalkanen S, MiyasakaM, Umemoto E. Fibroblastic reticular cell-derived lysophosphatidic acidregulates confined intranodal T-cell motility. Elife 2016; 5:.

Cordeiro O G, Chypre M, Brouard N, Rauber S, Alloush F, Romera-Hernandez M, Bénézech C, Li Z, Eckly A, Coles M C, Rot A, Yagita H, LéonC, Ludewig B, Cupedo T, Lanza F, Mueller C G. Integrin-Alpha IIbIdentifies Murine Lymph Node Lymphatic Endothelial Cells Responsive toRANKL. PLoS ONE 2016; 11:e0151848.

Novkovic M, Onder L, Cupovic J, Abe J, Bomze D, Cremasco V, ScandellaE, Stein J V, Bocharov G, Turley S J, Ludewig B. Topological Small-WorldOrganization of the Fibroblastic Reticular Cell Network Determines LymphNode Functionality. PLoS Biol 2016; 14:e1002515.

Cupovic J, Onder L, Gil Cruz C, Weiler E, Caviezel-Firner S, PerezShibayama C, Rülicke T, Bechmann I, Ludewig B. Central Nervous SystemStromal Cells Control Local CD8(+) T Cell Responses during Virus-Induced Neuroinflammation. Immunity 2016; 44:622-33.

Dubey L K, Lebon L, Mosconi I, Yang C Y, Scandella E, Ludewig B, LutherS A, Harris N L. Lymphotoxin-Dependent B Cell-FRC Crosstalk PromotesDe Novo Follicle Formation and Antibody Production following IntestinalHelminth Infection. Cell Rep 2016; 15:1527-41.

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journalpaper/review

Bösch M, Sopper S, Zeimet A G, Reimer D, Gastl G, Ludewig B, Wolf D.Heterogeneity of Cancer Stem Cells: Rationale for Targeting the StemCell Niche. Biochim Biophys Acta 2016; 1866:276-289.

Gil Cruz C, Perez Shibayama C, Onder L, chai q, Cupovic J, Cheng H W,Novkovic M, Lang P A, Geuking M B, McCoy K D, Abe S, Cui G, Ikuta K,Scandella E, Ludewig B. Fibroblastic reticular cells regulate intestinalinflammation via IL-15-mediated control of group 1 ILCs. Nat Immunol2016; 17:1388-1396.

Carreño J M, Perez Shibayama C, Gil Cruz C, printz a, Pastelin R, IsibasiA, Chariatte D, Tanoue Y, López-Macías C, Gander B, Ludewig B. PLGA-microencapsulation protects Salmonella typhi outer membrane proteinsfrom acidic degradation and increases their mucosal immunogenicity.Vaccine 2016; 34:4263-9.

Onder L, Ludewig B. Another TLO in the Wall: Education and Control of TCells in Atherosclerotic Arteries. Immunity 2015; 42:981-3.

Perez Shibayama C, Ludewig B. Tuning up FALCs: immunologicalshielding in the body cavities. Nat Immunol 2015; 16:796-8.

Onder L, Nindl V, Scandella E, chai q, Cheng H W, Caviezel-Firner S,Novkovic M, Bomze D, Maier R, Mair F, Ledermann B, Becher B, WaismanA, Ludewig B. Alternative NF-κB signaling regulates mTEC differentiationfrom podoplanin-expressing presursors in the cortico-medullary junction.Eur J Immunol 2015;.

Mair F, Joller S, Hoeppli R, Onder L, Hahn M, Ludewig B, Waisman A,Becher B. The NFκB-inducing kinase is essential for the developmentalprogramming of skin-resident and IL-17-producing γδ T cells. Elife 2015;4:.

18

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journalpaper/review

Bhattacharya A, Hegazy A N, Deigendesch N, Kosack L, Cupovic J,Kandasamy R K, Hildebrandt A, Merkler D, Kühl A A, Vilagos B, SchlieheC, Panse I, Khamina K, Baazim H, Arnold I, Flatz L, Xu H C, Lang P A,Aderem A, Takaoka A, Superti-Furga G, Colinge J, Ludewig B, Löhning M,Bergthaler A. Superoxide Dismutase 1 Protects Hepatocytes from Type IInterferon-Driven Oxidative Damage. Immunity 2015; 43:974-86.

Rodda L B, Bannard O, Ludewig B, Nagasawa T, Cyster J G. Phenotypicand Morphological Properties of Germinal Center Dark Zone Cxcl12-Expressing Reticular Cells. J Immunol 2015; 195:4781-91.

Tschismarov R, Firner S, Gil Cruz C, Göschl L, Boucheron N, Steiner G,Matthias P, Seiser C, Ludewig B, Ellmeier W. HDAC1 controls CD8+ T cellhomeostasis and antiviral response. PLoS ONE 2014; 9:e110576.

Moalli F, Cupovic J, Thelen F, Halbherr P, Fukui Y, Narumiya S, Ludewig B,Stein J V. Thromboxane A2 acts as tonic immunoregulator by preferentialdisruption of low-avidity CD4+ T cell-dendritic cell interactions. J Exp Med2014; 211:2507-17.

Fasnacht N, Huang H Y, Koch U, Favre S, Auderset F, chai q, Onder L,Kallert S, Pinschewer D D, MacDonald H R, Tacchini-Cottier F, Ludewig B,Luther S A, Radtke F. Specific fibroblastic niches in secondary lymphoidorgans orchestrate distinct Notch-regulated immune responses. J ExpMed 2014; 211:2265-79.

Astarita J L, Cremasco V, Fu J, Darnell M C, Peck J R, Nieves-Bonilla J M,Song K, Kondo Y, Woodruff M C, Gogineni A, Onder L, Ludewig B, WeimerR M, Carroll M C, Mooney D J, Xia L, Turley S J. The CLEC-2-podoplaninaxis controls the contractility of fibroblastic reticular cells and lymph nodemicroarchitecture. Nat Immunol 2014; 16:75-84.

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Perez Shibayama C, Gil Cruz C, Pastelin-Palacios R, Cervantes-BarraganL, Hisaki E, chai q, Onder L, Scandella E, Regen T, Waisman A, Isibasi A,López-Macías C, Ludewig B. IFN-γ-producing CD4+ T cells promotegeneration of protective germinal center-derived IgM+ B cell memoryagainst Salmonella Typhi. J Immunol 2014; 192:5192-200.

Sage A P, Murphy D, Maffia P, Masters L M, Sabir S R, Baker L L,Cambrook H, Finigan A J, Ait-Oufella H, Grassia G, Harrison J E, LudewigB, Reith W, Hansson G K, Reizis B, Hugues S, Mallat Z. MHC Class II-restricted antigen presentation by plasmacytoid dendritic cells drivesproatherogenic T cell immunity. Circulation 2014; 130:1363-73.

Perez Shibayama C, Gil Cruz C, Ludewig B. Plasticity and complexity of Bcell responses against persisting pathogens. Immunol Lett 2014;162:53-8.

Cremasco V, Woodruff M C, Onder L, Cupovic J, Nieves-Bonilla J M,Schildberg F A, Chang J, Cremasco F, Harvey C J, Wucherpfennig K,Ludewig B, Carroll M C, Turley S J. B cell homeostasis and follicle confinesare governed by fibroblastic reticular cells. Nat Immunol 2014;15:973-81.

Caviezel-Firner S, Engeler D S, Bolinger B, Onder L, Scandella E, Yu M,Kroczek R A, Ludewig B. Systemic minor histocompatibility antigenexpression in blood endothelial cells prevents T cell-mediated vascularimmunopathology. Eur J Immunol 2013; 43:3233-43.

Perez Shibayama C, Gil Cruz C, Nussbacher M, Allgäuer E, Cervantes-Barragan L, Züst R, Ludewig B. Dendritic cell-specific delivery of Flt3L bycoronavirus vectors secures induction of therapeutic antitumor immunity.PLoS ONE 2013; 8:e81442.

20

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chai q, Onder L, Scandella E, Gil Cruz C, Perez Shibayama C, Cupovic J,Danuser R, Sparwasser T, Luther S A, thiel v, Rülicke T, Stein J V,Hehlgans T, Ludewig B. Maturation of lymph node fibroblastic reticularcells from myofibroblastic precursors is critical for antiviral immunity.Immunity 2013; 38:1013-24.

Coelho F M, Natale D, Soriano S F, Hons M, Swoger J, Mayer J, DanuserR, Scandella E, Pieczyk M, Zerwes H G, Junt T, Sailer A W, Ludewig B,Sharpe J, Figge M T, Stein J V. Naive B-cell trafficking is shaped by localchemokine availability and LFA-1-independent stromal interactions. Blood2013; 121:4101-9.

Bocharov G, Luzyanina T, Cupovic J, Ludewig B. Asymmetry of CellDivision in CFSE-Based Lymphocyte Proliferation Analysis. Front Immunol2013; 4:264.

Iolyeva M, Aebischer D, Proulx S T, Willrodt A H, Ecoiffier T, Häner S,Bouchaud G, Krieg C, Onder L, Ludewig B, Santambrogio L, Boyman O,Chen L, Finke D, Halin C. Interleukin-7 is produced by afferent lymphaticvessels and supports lymphatic drainage. Blood 2013; 122:2271-81.

Bolinger B, Sims S, O'Hara G, de Lara C, Tchilian E, Firner S, Engeler D S,Ludewig B, Klenerman P. A new model for CD8+ T cell memory inflationbased upon a recombinant adenoviral vector. J Immunol 2013;190:4162-74.

Luzyanina T, Cupovic J, Ludewig B, Bocharov G. Mathematical models forCFSE labelled lymphocyte dynamics: asymmetry and time-lag in division.J Math Biol 2013;.

21

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Onder L, Danuser R, Scandella E, Firner S, chai q, Hehlgans T, Stein J V,Ludewig B. Endothelial cell-specific lymphotoxin-β receptor signaling iscritical for lymph node and high endothelial venule formation. J Exp Med2013; 210:465-73.

mueller r, Maier R, Hoschler K, Zambon M, Ludewig B, Herrmann M,Schulze-Koops H, von Kempis J. Efficient boosting of the antiviral T cellresponse in B cell-depleted patients with autoimmune rheumatic diseasesfollowing influenza vaccination. Clin Exp Rheumatol 2013; 31:723-30.

Weber S S, Joller N, Küntzel A B, Spörri R, Tchang V S, Scandella E, RösliC, Ludewig B, Hilbi H, Oxenius A. Identification of protective B cellantigens of Legionella pneumophila. J Immunol 2012; 189:841-9.

Ludewig B, Stein J V, Sharpe J, cervantes l, thiel v, Bocharov G. A global"imaging'' view on systems approaches in immunology. Eur J Immunol2012; 42:3116-25.

Cervantes-Barragan L, Bechmann I, Waisman A, Lahl K, Sparwasser T,thiel v, Ludewig B. Regulatory T cells selectively preserve immuneprivilege of self-antigens during viral central nervous system infection. JImmunol 2012; 188:3678-85.

nindl v, Maier R, Ratering D, De Giuli R, Züst R, thiel v, Scandella E, DiPadova F, Kopf M, Rudin M, Rülicke T, Ludewig B. Cooperation of Th1 andTh17 cells determines transition from autoimmune myocarditis to dilatedcardiomyopathy. Eur J Immunol 2012; 42:2311-21.

Onder L, nindl v, Ludewig B. Tight control - decision-making during T cell-vascular endothelial cell interaction. Front Immunol 2012; 3:279.

22

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Frebel H, nindl v, Schuepbach R A, Braunschweiler T, Richter K, Vogel J,Wagner C A, Loffing-Cueni D, Kurrer M, Ludewig B, Oxenius A.Programmed death 1 protects from fatal circulatory failure duringsystemic virus infection of mice. J Exp Med 2012; 209:2485-99.

Onder L, Narang P, Scandella E, chai q, Iolyeva M, Hoorweg K, Halin C,Richie E, Kaye P, Westermann J, Cupedo T, Coles M, Ludewig B. IL-7-producing stromal cells are critical for lymph node remodeling. Blood2012; 120:4675-83.

Engeler D S, Scandella E, Ludewig B, Schmid H P. Ciprofloxacin andepirubicin synergistically induce apoptosis in human urothelial cancer celllines. Urol Int 2012; 88:343-9.

Gil Cruz C, Perez Shibayama C, Waisman A, Bechmann I, thiel v,cervantes l, Ludewig B. T helper cell- and CD40-dependent germline IgMprevents chronic virus-induced demyelinating disease. Proc Natl Acad SciUSA 2012; 109:1233-8.

cervantes l, Lewis K L, thiel v, Hugues S, Reith W, Ludewig B, Reizis B.Plasmacytoid dendritic cells control T-cell response to chronic viralinfection. Proc Natl Acad Sci USA 2012; 109:3012-7.

zuest r, cervantes l, habjan m, Maier R, Neuman B W, Ziebuhr J, SzretterK J, Baker S C, Barchet W, Diamond M S, Siddell S G, Ludewig B, thiel v.Ribose 2'-O-methylation provides a molecular signature for thedistinction of self and non-self mRNA dependent on the RNA sensorMda5. Nat Immunol 2011; 12:137-43.

23

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Pastelin-Palacios R, Gil Cruz C, Perez Shibayama C, Moreno-Eutimio M A,cervantes l, Arriaga-Pizano L, Ludewig B, Cunningham A F, García-ZepedaE A, Becker I, Alpuche-Aranda C, Bonifaz L, Gunn J S, Isibasi A, López-Macías C. Subversion of innate and adaptive immune activation inducedby structurally modified lipopolysaccharide from Salmonella typhimurium.Immunology 2011; 133:469-81.

Ludewig B, cervantes l. CD169(+) macrophages take the bullet. NatImmunol 2011; 13:13-4.

Bocharov G A, Danilov A A, Vassilevski Y V, Marchuk G I, Chereshnev V A,Ludewig B. Simulation of the interferon-mediated protective field inlymphoid organs with their spatial and functional organization taken intoconsideration. Dokl Biol Sci 2011; 439:194-6.

Onder L, Scandella E, chai q, Mayer C T, Sparwasser T, thiel v, Rülicke T,Ludewig B. A novel bacterial artificial chromosome-transgenicpodoplanin-cre mouse targets lymphoid organ stromal cells in vivo. FrontImmunol 2011; 2:50.

Kumar V, Scandella E, Danuser R, Onder L, Nitschké M, Fukui Y, Halin C,Ludewig B, Stein J V. Global lymphoid tissue remodeling during a viralinfection is orchestrated by a B cell-lymphotoxin-dependent pathway.Blood 2010; 115:4725-33.

Schwendener R A, Ludewig B, Cerny A, Engler O. Liposome-basedvaccines. Methods in molecular biology (Clifton, N.J.) 2010; 605:163-75.

24

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Lang P A, Recher M, Honke N, Scheu S, Borkens S, Gailus N, Krings C,Meryk A, Kulawik A, cervantes l, Van Rooijen N, Kalinke U, Ludewig B,Hengartner H, Harris N, Häussinger D, Ohashi P S, Zinkernagel R M, LangK S. Tissue macrophages suppress viral replication and prevent severeimmunopathology in an interferon-I-dependent manner in mice.Hepatology 2010; 52:25-32.

bolinger b, Engeler D S, Krebs P, Miller S, Hoffmann M, Palmer D C,Restifo N P, Tian Y, Clavien P A, Ludewig B. IFN-gamma-receptorsignaling ameliorates transplant vasculopathy through attenuation ofCD8+ T-cell-mediated injury of vascular endothelial cells. Eur J Immunol2010; 40:733-43.

Bocharov G, zuest r, cervantes l, Luzyanina T, Chiglintsev E, ChereshnevV A, thiel v, Ludewig B. A systems immunology approach to plasmacytoiddendritic cell function in cytopathic virus infections. PLoS Pathog 2010; 6:e1001017.

cervantes l, zuest r, Maier R, Sierro S, Janda J, Levy F, Speiser D, RomeroP, Rohrlich P S, Ludewig B, thiel v. Dendritic cell-specific antigen deliveryby coronavirus vaccine vectors induces long-lasting protective antiviraland antitumor immunity. MBio 2010; 1:.

Lang P A, cervantes l, Verschoor A, Navarini A A, Recher M, Pellegrini M,Flatz L, Bergthaler A, Honda K, Ludewig B, Ohashi P S, Lang K S.Hematopoietic cell-derived interferon controls viral replication and virus-induced disease. Blood 2009; 113:1045-52.

Zinkernagel M S, bolinger b, Krebs P, Onder L, Miller S, Ludewig B.Immunopathological basis of lymphocytic choriomeningitis virus-inducedchorioretinitis and keratitis. Journal of virology 2009; 83:159-66.

25

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cervantes l, Kalinke U, zuest r, König M, Reizis B, López-Macías C, thiel v,Ludewig B. Type I IFN-mediated protection of macrophages and dendriticcells secures control of murine coronavirus infection. Journal ofimmunology (Baltimore, Md. : 1950) 2009; 182:1099-106.

Engeler D S, Ludewig B, Schmid H P. [Uro-oncological research from thelaboratory and clinical practice]. Der Urologe. Ausg. A 2008; 47:978-81.

Lang P A, Contaldo C, Georgiev P, El-Badry A M, Recher M, Kurrer M,cervantes l, Ludewig B, Calzascia T, bolinger b, Merkler D, Odermatt B,Bader M, Graf R, Clavien P A, Hegazy A N, Löhning M, Harris N L, OhashiP S, Hengartner H, Zinkernagel R M, Lang K S. Aggravation of viralhepatitis by platelet-derived serotonin. Nature medicine 2008;14:756-61.

Kang T B, Oh G S, Scandella E, bolinger b, Ludewig B, Kovalenko A,Wallach D. Mutation of a self-processing site in caspase-8 compromisesits apoptotic but not its nonapoptotic functions in bacterial artificialchromosome-transgenic mice. Journal of immunology (Baltimore, Md. :1950) 2008; 181:2522-32.

Junt T, Scandella E, Ludewig B. Form follows function: lymphoid tissuemicroarchitecture in antimicrobial immune defence. Nature reviews.Immunology 2008; 8:764-75.

Scandella E, bolinger b, Lattmann E, Miller S, Favre S, Littman D R, FinkeD, Luther S A, Junt T, Ludewig B. Restoration of lymphoid organ integritythrough the interaction of lymphoid tissue-inducer cells with stroma ofthe T cell zone. Nature immunology 2008; 9:667-75.

26

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Birnberg T, Bar-On L, Sapoznikov A, Caton M L, cervantes l, makia d,Krauthgamer R, Brenner O, Ludewig B, Brockschnieder D, RiethmacherD, Reizis B, Jung S. Lack of conventional dendritic cells is compatible withnormal development and T cell homeostasis, but causes myeloidproliferative syndrome. Immunity 2008; 29:986-97.

Eriksson K K, cervantes l, Ludewig B, thiel v. Mouse hepatitis virus liverpathology is dependent on ADP-ribose-1''-phosphatase, a viral functionconserved in the alpha-like supergroup. Journal of virology 2008;82:12325-34.

bolinger b, Krebs P, Tian Y, Engeler D S, Scandella E, Miller S, Palmer DC, Restifo N P, Clavien P A, Ludewig B. Immunologic ignorance of vascularendothelial cells expressing minor histocompatibility antigen. Blood 2008;111:4588-95.

Krebs P, Scandella E, bolinger b, Engeler D S, Miller S, Ludewig B.Chronic immune reactivity against persisting microbial antigen in thevasculature exacerbates atherosclerotic lesion formation. Arteriosclerosis,thrombosis, and vascular biology 2007; 27:2206-13.

Scandella E, Fink K, Junt T, Senn B M, Lattmann E, Förster R, HengartnerH, Ludewig B. Dendritic cell-independent B cell activation during acutevirus infection: a role for early CCR7-driven B-T helper cell collaboration.Journal of immunology (Baltimore, Md. : 1950) 2007; 178:1468-76.

Pochanke V, Koller S, Dayer R, Hatak S, Ludewig B, Zinkernagel R M,Hengartner H, McCoy K D. Identification and characterization of a novelantigen from the nematode Nippostrongylus brasiliensis recognized byspecific IgE. European journal of immunology 2007; 37:1275-84.

27

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zuest r, cervantes l, Kuri T, Blakqori G, Weber F, Ludewig B, thiel v.Coronavirus non-structural protein 1 is a major pathogenicity factor:implications for the rational design of coronavirus vaccines. PLoSPathogens 2007; 10;3(8):e109:1062-1072.

Krebs P, Kurrer M O, Kremer M, De Giuli R, Sonderegger I, Henke A,Maier R, Ludewig B. Molecular mapping of autoimmune B cell responsesin experimental myocarditis. Journal of autoimmunity 2007; 28:224-33.

Eriksson K K, makia d, Maier R, Ludewig B, thiel v. Towards acoronavirus-based HIV multigene vaccine. Clinical & developmentalimmunology 2006; 13:353-60.

Klenerman P, Ludewig B. Virus scores a perfect 10. Nature medicine2006; 12:1246-8.

Bonilla W V, Geuking M B, Aichele P, Ludewig B, Hengartner H,Zinkernagel R M. Microchimerism maintains deletion of the donor cell-specific CD8+ T cell repertoire. The Journal of clinical investigation 2006;116:156-62.

Waeckerle-Men Y, Uetz-Von Allmen E, Fopp M, von Moos R, boehme c,Schmid H P, Ackermann D, cerny t, Ludewig B, Groettrup M, GillessenSommer S. Dendritic cell-based multi-epitope immunotherapy ofhormone-refractory prostate carcinoma. Cancer immunology,immunotherapy : CII 2006; 55:1524-33.

Sahin U, Türeci O, Graf C, Meyer R G, Lennerz V, Britten C M, Dumrese C,Scandella E, Wölfel T, Ludewig B. Rapid molecular dissection of viral andbacterial immunomes. European journal of immunology 2006;36:1049-57.

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Junt T, Tumanov A V, Harris N, Heikenwalder M, Zeller N, Kuprash D V,Aguzzi A, Ludewig B, Nedospasov S A, Zinkernagel R M. Expression oflymphotoxin beta governs immunity at two distinct levels. Europeanjournal of immunology 2006; 36:2061-75.

Chen L, Gui C, Luo X, Yang Q, Günther S, Scandella E, Drosten C, Bai D,He X, Ludewig B, Chen J, Luo H, Yang Y, Yang Y, Zou J, thiel v, Chen K,Shen J, Shen X, Jiang H. Cinanserin is an inhibitor of the 3C-likeproteinase of severe acute respiratory syndrome coronavirus andstrongly reduces virus replication in vitro. Journal of virology 2005;79:7095-103.

Waeckerle-Men Y, Allmen E U V, von Moos R, Classon B J, Scandella E,Schmid H P, Ludewig B, Groettrup M, Gillessen Sommer S. Dendritic cellsgenerated from patients with androgen-independent prostate cancer arenot impaired in migration and T-cell stimulation. The Prostate 2005;64:323-31.

Junt T, Fink K, Förster R, Senn B, Lipp M, Muramatsu M, Zinkernagel R M,Ludewig B, Hengartner H. CXCR5-dependent seeding of follicular nichesby B and Th cells augments antiviral B cell responses. Journal ofimmunology (Baltimore, Md. : 1950) 2005; 175:7109-16.

Schelle B, Karl N, Ludewig B, Siddell S G, thiel v. Selective replication ofcoronavirus genomes that express nucleocapsid protein. Journal ofvirology 2005; 79:6620-30.

Maier R, Miller S, Kurrer M, Krebs P, De Giuli R, Kremer M, Scandella E,Ludewig B. Quantification and characterization of myosin peptide-specificCD4+ T cells in autoimmune myocarditis. J Immunol Methods 2005;304:117-25.

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Krebs P, Scandella E, Odermatt B, Ludewig B. Rapid functional exhaustionand deletion of CTL following immunization with recombinant adenovirus.Journal of immunology (Baltimore, Md. : 1950) 2005; 174:4559-66.

Bocharov G, Ford N J, Ludewig B. A mathematical approach foroptimizing dendritic cell-based immunotherapy. Methods in molecularmedicine 2005; 109:19-34.

Ludewig B, Laman J D. The in and out of monocytes in atheroscleroticplaques: Balancing inflammation through migration. Proceedings of theNational Academy of Sciences of the United States of America 2004;101:11529-30.

Ludewig B, Krebs P, Scandella E. Immunopathogenesis of atherosclerosis.Journal of leukocyte biology 2004; 76:300-6.

Scandella E, Men Y, Legler D F, Gillessen Sommer S, Prikler L, Ludewig B,Groettrup M. CCL19/CCL21-triggered signal transduction and migration ofdendritic cells requires prostaglandin E2. Blood 2004; 103:1595-601.

Ludewig B, Krebs P, Junt T, Metters H, Ford N J, Anderson R M, BocharovG. Determining control parameters for dendritic cell-cytotoxic Tlymphocyte interaction. European journal of immunology 2004;34:2407-18.

Bocharov G, Ludewig B, Bertoletti A, Klenerman P, Junt T, Krebs P,Luzyanina T, Fraser C, Anderson R M. Underwhelming the immuneresponse: effect of slow virus growth on CD8+-T-lymphocyte responses.Journal of virology 2004; 78:2247-54.

Maier R, Krebs P, Ludewig B. Immunopathological basis of virus-inducedmyocarditis. Clinical & developmental immunology 2004; 11:1-5.

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Waeckerle-Men Y, Scandella E, Uetz-Von Allmen E, Ludewig B, GillessenSommer S, Merkle H P, Gander B, Groettrup M. Phenotype and functionalanalysis of human monocyte-derived dendritic cells loaded withbiodegradable poly(lactide-co-glycolide) microspheres forimmunotherapy. Journal of immunological methods 2004; 287:109-24.

Prikler L, Scandella E, Men Y, Engeler D S, Diener P A, Gillessen SommerS, Ludewig B, Schmid H P. [Adaptive immunotherapy of the advancedprostate cancer - cancer testis antigen (CTA) as possible targetantigens]. Aktuelle Urologie 2004; 35:326-30.

Ludewig B, Krebs P, Metters H, Tatzel J, Türeci O, Sahin U. Molecularcharacterization of virus-induced autoantibody responses. The Journal ofexperimental medicine 2004; 200:637-46.

Hertzig T, Scandella E, Schelle B, Ziebuhr J, Siddell S G, Ludewig B, thielv. Rapid identification of coronavirus replicase inhibitors using aselectable replicon RNA. The Journal of general virology 2004;85:1717-25.

Prikler L, Scandella E, Men Y, Engeler D S, Diener P A, Gillessen SommerS, Ludewig B, Schmid H P. Adaptive Immuntherapie des fortgeschrittenenProstatakarzinoms: Cancer Testis Antigene (CTA) als möglicheZielantigene. Aktuel Urol 2004; 35:326-330.

Junt T, Scandella E, Förster R, Krebs P, Krautwald S, Lipp M, HengartnerH, Ludewig B. Impact of CCR7 on priming and distribution of antiviraleffector and memory CTL. Journal of immunology (Baltimore, Md. :1950) 2004; 173:6684-93.

Ludewig B, Krebs P, Junt T, Bocharov G. Dendritic cell homeostasis in theregulation of self-reactivity. Current pharmaceutical design 2003;9:221-31.

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Ludewig B. Dendritic cell vaccination and viral infection--animal models.Current topics in microbiology and immunology 2003; 276:199-214.

Krebs P, Kurrer M, Sahin U, Türeci O, Ludewig B. Autoimmunity seenthrough the SEREX-scope. Autoimmunity reviews 2003; 2:339-45.

Junt T, Nakano H, Dumrese T, Kakiuchi T, Odermatt B, Zinkernagel R M,Hengartner H, Ludewig B. Antiviral immune responses in the absence oforganized lymphoid T cell zones in plt/plt mice. Journal of immunology(Baltimore, Md. : 1950) 2002; 168:6032-40.

Ludewig B, Zinkernagel R M, Hengartner H. Arterial inflammation andatherosclerosis. Trends in cardiovascular medicine 2002; 12:154-9.

Hu Y, Davison F, Ludewig B, Erdel M, Mayr M, Url M, Dietrich H, Xu Q.Smooth muscle cells in transplant atherosclerotic lesions are originatedfrom recipients, but not bone marrow progenitor cells. Circulation 2002;106:1834-9.

Ludewig B. Tracking arterial smooth muscle-specific T cells in theinflamed vasculature. Advances in experimental medicine and biology2002; 512:183-9.

Ludewig B, Jäggi M, Dumrese T, Brduscha-Riem K, Odermatt B,Hengartner H, Zinkernagel R M. Hypercholesterolemia exacerbates virus-induced immunopathologic liver disease via suppression of antiviralcytotoxic T cell responses. Journal of immunology (Baltimore, Md. :1950) 2001; 166:3369-76.

Ludewig B, McCoy K, Pericin M, Ochsenbein A F, Dumrese T, Odermatt B,Toes R E, Melief C J, Hengartner H, Zinkernagel R M. Rapid peptideturnover and inefficient presentation of exogenous antigen critically limitthe activation of self-reactive CTL by dendritic cells. Journal ofimmunology (Baltimore, Md. : 1950) 2001; 166:3678-87.

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Ludewig B, Junt T, Hengartner H, Zinkernagel R M. Dendritic cells inautoimmune diseases. Current opinion in immunology 2001; 13:657-62.

Ludewig B, Bonilla W V, Dumrese T, Odermatt B, Zinkernagel R M,Hengartner H. Perforin-independent regulation of dendritic cellhomeostasis by CD8(+) T cells in vivo: implications for adaptiveimmunotherapy. European journal of immunology 2001; 31:1772-9.

Ludewig B, Ochsenbein A F, Odermatt B, Paulin D, Hengartner H,Zinkernagel R M. Immunotherapy with dendritic cells directed againsttumor antigens shared with normal host cells results in severeautoimmune disease. The Journal of experimental medicine 2000;191:795-804.

Ludewig B, Maloy K J, López-Macías C, Odermatt B, Hengartner H,Zinkernagel R M. Induction of optimal anti-viral neutralizing B cellresponses by dendritic cells requires transport and release of virusparticles in secondary lymphoid organs. European journal of immunology2000; 30:185-96.

Suter T, Malipiero U, Otten L, Ludewig B, Muelethaler-Mottet A, Mach B,Reith W, Fontana A. Dendritic cells and differential usage of the MHCclass II transactivator promoters in the central nervous system inexperimental autoimmune encephalitis. European journal of immunology2000; 30:794-802.

Ludewig B, Barchiesi F, Pericin M, Zinkernagel R M, Hengartner H,Schwendener R A. In vivo antigen loading and activation of dendritic cellsvia a liposomal peptide vaccine mediates protective antiviral and anti-tumour immunity. Vaccine 2000; 19:23-32.

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Ludewig B, Zinkernagel R M, Hengartner H. Transgenic animal models forvirus-induced autoimmune diseases. Experimental physiology 2000;85:653-9.

Beier K C, Hutloff A, Dittrich A M, Heuck C, Rauch A, Büchner K, LudewigB, Ochs H D, Mages H W, Kroczek R A. Induction, binding specificity andfunction of human ICOS. European journal of immunology 2000;30:3707-17.

Ludewig B, Freigang S, Jäggi M, Kurrer M O, Pei Y C, Vlk L, Odermatt B,Zinkernagel R M, Hengartner H. Linking immune-mediated arterialinflammation and cholesterol-induced atherosclerosis in a transgenicmouse model. Proceedings of the National Academy of Sciences of theUnited States of America 2000; 97:12752-7.

Ochsenbein A F, Klenerman P, Karrer U, Ludewig B, Pericin M, HengartnerH, Zinkernagel R M. Immune surveillance against a solid tumor failsbecause of immunological ignorance. Proceedings of the NationalAcademy of Sciences of the United States of America 1999; 96:2233-8.

Maloy K J, Burkhart C, Freer G, Rülicke T, Pircher H, Kono D H,Theofilopoulos A N, Ludewig B, Hoffmann-Rohrer U, Zinkernagel R M,Hengartner H. Qualitative and quantitative requirements for CD4+ T cell-mediated antiviral protection. Journal of immunology (Baltimore, Md. :1950) 1999; 162:2867-74.

Ludewig B, Oehen S, Barchiesi F, Schwendener R A, Hengartner H,Zinkernagel R M. Protective antiviral cytotoxic T cell memory is mostefficiently maintained by restimulation via dendritic cells. Journal ofimmunology (Baltimore, Md. : 1950) 1999; 163:1839-44.

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Ludewig B, Odermatt B, Ochsenbein A F, Zinkernagel R M, Hengartner H.Role of dendritic cells in the induction and maintenance of autoimmunediseases. Immunological reviews 1999; 169:45-54.

Ludewig B, Odermatt B, Landmann S, Hengartner H, Zinkernagel R M.Dendritic cells induce autoimmune diabetes and maintain disease via denovo formation of local lymphoid tissue. The Journal of experimentalmedicine 1998; 188:1493-501.

Ludewig B, Ehl S, Karrer U, Odermatt B, Hengartner H, Zinkernagel R M.Dendritic cells efficiently induce protective antiviral immunity. Journal ofvirology 1998; 72:3812-8.

Häusser G, Ludewig B, Gelderblom H R, Tsunetsugu-Yokota Y, Akagawa K,Meyerhans A. Monocyte-derived dendritic cells represent a transientstage of differentiation in the myeloid lineage. Immunobiology 1997;197:534-42.

Ludewig B, Gelderblom H R, Becker Y, Schäfer A, Pauli G. Transmission ofHIV-1 from productively infected mature Langerhans cells to primaryCD4+ T lymphocytes results in altered T cell responses with enhancedproduction of IFN-gamma and IL-10. Virology 1996; 215:51-60.

Ludewig B, Henn V, Schröder J M, Graf D, Kroczek R A. Induction,regulation, and function of soluble TRAP (CD40 ligand) during interactionof primary CD4+ CD45RA+ T cells with dendritic cells. European journalof immunology 1996; 26:3137-43.

Ludewig B, Graf D, Gelderblom H R, Becker Y, Kroczek R A, Pauli G.Spontaneous apoptosis of dendritic cells is efficiently inhibited by TRAP(CD40-ligand) and TNF-alpha, but strongly enhanced by interleukin-10.European journal of immunology 1995; 25:1943-50.

35

publications

title

journalpaper/review

Ludewig B, Holzmeister J, Gentile M, Gelderblom H R, Rokos K, Becker Y,Pauli G. Replication pattern of human immunodeficiency virus type 1 inmature Langerhans cells. The Journal of general virology 1995; 76 ( Pt6):1317-25.

Holzmeister J, Ludewig B, Pauli G, Simon D. Sequence specific binding ofthe transcription factor c-Ets1 to the human immunodeficiency virus typeI long terminal repeat. Biochemical and biophysical researchcommunications 1993; 197:1229-33.

book Ludewig B, & Hoffmann M (2005). Adoptive Immunotherapy: Methodsand Protocols. Totowa, New Jersey: Humana Press.

bookchapter

Ludewig B, & Laman J D (2007). The immune system in the pathogenesisof vascular disease. In Essentials of restenosis for the interventionalcardiologist (pp. 85-130). Totowa, New Jersey: Humana Press.

Ludewig B, & Krebs P (2006). A transgenic mouse model for virus-induced vasculitis. In Xu Q (Eds.), A Handbook of Mouse Models ofCardiovascular Disease (pp. 321-332). Chichester, UK: Wiley.

Ludewig B, & Bocharov G (2006). A systems biologist's view on dendriticcell-cytotoxic T lymphocyte interaction. In Lutz M, Romani N, &Steinkasserer A (Eds.), Handbook of Dendritic Cells (pp. 455-480).Weinheim: Wiley-VCH.

Ludewig B, & Krebs P (2004). How transgenic mouse models contributeto a better understanding of virus-induced autoimmunity. In Rose N, &Shoenfeld Y (Eds.), Infection and Autoimmunity (pp. 155-162): ElsevierScience.

36

publications

title

bookchapter

Ludewig B, Maloy K J, Hengartner H, & Zinkernagel R M (2000).Virustransport durch dendritische Zellen: Trojanisches Pferd oderAlarmsignal für erfolgreiche Verteidigung?. In HIV-Infekt (pp. 72-76).Heidelberg: Springer.

conferencepaper/poster

Bocharov G, Eriksson K K, Ludewig B, & cervantes l (2007). Mathematicalmodelling of the antiviral type I interferon response. In Proceedings -Plenary and Contributed Papers.

Schelle B, Karl N, Ludewig B, Siddell S G, & thiel v (2006). Nucleocapsidprotein expression facilitates coronavirus replication. In Advances inexperimental medicine and biology (pp. 43-8): Springer.

Eriksson K K, makia d, Maier R, cervantes l, Ludewig B, & thiel v (2006).Efficient transduction of dendritic cells using coronavirus-based vectors.In Advances in experimental medicine and biology (pp. 203-6): Springer.

Scandella E, Eriksson K K, Hertzig T, Drosten C, Chen L, Gui C, Luo X,Shen J, Shen X, Siddell S G, Ludewig B, Jiang H, Günther S, & thiel v(2006). Identification and evaluation of coronavirus replicase inhibitorsusing a replicon cell line. In Advances in experimental medicine andbiology (pp. 609-13): Springer.

Ludewig B, Aichele P, Hengartner H, & Zinkernagel R M (1999).Mechanisms of virus-induced autoimmunity. In . Lancaster: Kluwer.

37

projects

title status

Deciphering the molecular landscape of the stromal cells inhuman lymph nodes at the single-cell level

ongoing-recruitingphase

Inorganic Nanoparticles with Anti-inflammatory andAntimicrobial Activity: New Prospects for Long-term LocalImmunoimodulation?

ongoing-recruitingphase

Deciphering the transcriptomic landscape of cancer-associatedfibroblasts in pancreatic cancer / Oncological Research

ongoing-recruitingphase

Transcriptomic analysis of the B and T cell repertoire in MultipleSclerosis – an exploratory study

ongoing-recruitingphase

Identification and manipulation of immune-stimulatingfibroblastic stromal cell niches in the

ongoing-recruitingphase

38

projects

title status

Stromal Cell Niches at the Nexus of the Innate Lymphoid CellInteractome

ongoing-recruitingphase

Deciphering the transcriptomic landscape of cancer-associatedfibroblasts in pancreatic cancer – an exploratory clinical study

completed

Defining the identity and differentiation pathways of theimmune-stimulating fibroblastic tumor stroma

ongoing-recruitingphase

Dissecting the association of anti-microbiota antibodies andauto-reactive T-cells in cardiomyopathy– an exploratoryresearch Project

ongoing- followup

Dissecting the association of the human palatine tonsilmicrobiome and HPV-driven oropharyngeal squamous cellcarcinoma

ongoing-recruitingphase

Targeting breast cancer through manipulation of IL-7 producingtumor fibroblasts

automat-icallyclosed

Defining the origin of lymph node and Peyer's patch fibroblasticreticular cells at single cell resolution

automat-icallyclosed

39

projects

title status

Constructing accessory lymph nodes in situ for control ofmammary carcinoma

automat-icallyclosed

Impact of omental fibroblastic stromal cells on the induction ofanti-bacterial immunity

automat-icallyclosed

Ontogeny and functional characterization of splenic fibroblasticreticular cells (FRCs) and their mesenchymal precursors duringhomeostasis, immune-activation and infection

automat-icallyclosed

Blockade der Fibroblastenreifung zum Schutz vor autoimmunerSehnerventzündung

automat-icallyclosed

Role of activated fibroblastic stromal cells in relapsing-remittingexperimental autoimmune encephalomyelitis

automat-icallyclosed

Selection and education of heart-specific Th cells by thymic andlymph node stromal cells

completed

Clinical evaluation of a polyvalent vaccine against Salmonellaenterica in a phase I/II Study

automat-icallyclosed

40

projects

title status

Role CCR7-ligands in virus-induced chronic CNS inflammationand demyelination

completed

Systems biology approach to molecularly characterize the lungcancer microenvironment

completed

Stroma Cell- Immune Cell Interactions in Health and Disease completed

Systems biology approach to moleculary characterize the lungcancer microenvironment

completed

Systems immunological analysis of lymph node structure andfunction in viral infection

completed

Stromal Cell - Immune Cell Interactions in Health and Disease completed

Imaging-based Systems Biology Analysis of Lymph NodeStructure and Function in Viral Infection

automat-icallyclosed

Systembiologische Untersuchungen zur molekularenCharakterisierung der Mikroumgebung in Lungentumoren

completed

Funktionelle Charakterisierung und therapeutische Nutzung desmesenchymalen Tumorstromas

completed

Mechanisms of antibody-mediated protection against virus-induced inflammatory demyelination

completed

Polyvalent vaccine against Salmonellosis completed

41

projects

title status

Analyse der T-Zellfunktion bei Virus induzierter Chorioretinitis completed

Role of T helper cells in cardiovascular immunopathologicaldisease

completed

Impact of immune regulation on virus-induced chronic CNSinflammation and demyelination

completed

Examining the function of lymphoid organ structure duringantiviral immune responses using microscopic and mesoscopicimaging

completed

Impact of immune regulation on virus-induced chronic CNSinflammation and demyelination

completed

Entwicklung einer Coronavirus basierten Multigenvakzine zumSchutz gegen Tumorerkrankungen

completed

TOLERAGE: Normalisation of immune reactivity in old age –from basic mechanisms to clinical application

completed

Preventing autoimmune myocarditis through cardiac myosin-specific tolerance

completed

Immunpathologie der Virus induzierten Chorioretinitis completed

Multiepitop Imfpung von Grad III/IV Melanompatienten mitdendritischen Zellen: Bedeutung von Peptidaffinität und -dichtefür die optimale Generierung von tumorspezifischenzytotoxischen T-Lymphozyten

completed

42

projects

title status

Role of professional and non-professional antigen presentingcells in cardiovascular immunopathological disease

completed

AIDS-CoVAC: Generation of a coronavirus-based multigeneAIDS vaccine and evaluation in a preclinical SIV model

completed

Coronavirus-based multigene HIV vaccine vectors completed