BLOCKING DNA REPAIR ENZYME AND LEAD TO

CANCER THERAPY AND A NEW GENERATION OF

TUBERCULOSIS DRUGS

Felipe Osorio Ospina

Medicine Student

2012

FOLDING

FOLDING

INTRODUCTION

Science news line (Feb. 11,2012)

BLOCKING DNA REPAIR ENZYME

COULD EVENTUALLY

LEAD TO CANCER

THERAPY.

Blocking DNA repair enzyme could eventually lead to cancer therapy. Science news line (Feb. 11,2012)

They solved the structure of a DNA

repair enzyme called PNKP.

It could one day be used to develop

new therapies that target certain types

of cancersTaken of http://es.wikipedia.org/wiki/Archivo:DNA_Repair.jpg

Damaging DNA in cancer cells is a useful way to kill them blocking

PNKP from doing its repair work in cancer

cells as a possible new cancer therapy.

 

Blocking DNA repair enzyme could eventually lead to cancer therapy. Science news line (Feb. 11,2012)

Taken of http://publicacionescirculodaikon.wordpress.com/page/2/

The holy grail of cancer therapy is to find drugs that we

could give to people that would sensitize

their tumours to these therapies, one of the ideas is that we could specifically inhibit this

PNKP enzyme.

Taken of http://docente.ucol.mx/al018752/public_html/imagen.htm

Blocking DNA repair enzyme could eventually lead to cancer therapy. Science news line (Feb. 11,2012)

A different way to attack cancer´s cells is a great opportunity to

obtain a succesful treatment and reduce secundary effects, like obtains with chemotherapy. I

think if it can be used for differents cancer´s types it will be

the way to solve this patology.

Observation

A NEW GENERATION OF

TUBERCULOSIS

DRUGS. RSC (FEB. 9,

2012)

Targeting enzymes responsible for catalysing the formation of bonds to

repair of DNA, DNA ligases, allows the ever-

growing health concern of multi-drug resistant

bacteria

Taken of http://ecodiario.eleconomista.es/ciencia/noticias/3608278/12/11/Descubre-por-que-las-celulas-de-tuberculosis-son-resistentes-a-los-antibioticos.html

A NEW GENERATION OF TUBERCULOSIS DRUGS.

RSC (FEB. 9, 2012)

Humans only have the DNA ligases that utilise ATP.

NAD+-dependent ligase is indispensable in several bacterial, including Mycobacterium tuberculosis and Escherichia coli, making them attractive drug targets.

A NEW GENERATION OF TUBERCULOSIS DRUGS.

RSC (FEB. 9, 2012)

Taken of http://www.health-healths.com/usually-mycobacterium-tuberculosis/usually-mycobacterium-tuberculosis.php

Finally developing new small molecule compounds that

are able to distinguish between ATP- and NAD+-

dependent ligases, is important for engineering molecules with increased

levels of specificity.

A NEW GENERATION OF TUBERCULOSIS DRUGS.

RSC (FEB. 9, 2012)

Taken of http://www.corbisimages.com/stock-photo/rights-managed/HU010984/pharmacist-creating-streptomycin?popup=1

The identification of drug targets is very important to improve de efficiency of tuberculosis therapy and other disseases. Also it brinds the oporttunity to attack differents moleculars targets and avoid the antibiotic resistance.

OBSERVATION

Medical Utiliy

The investigation in infected cells give a new opporttunity for treatment and more eficciency of them in mutated cells.

Medical Utiliy

Taken of http://blogdecienciassocialesyhumanas.blogspot.com/2010/06/algo-sobre-la-investigacion-social-y.html

The comprehension of the structure in some virus, give us the tools to attack the drugs resistance.Taken

of http://www.corbisimages.com/stock-photo/rights-managed/SF21876/dr-kochs-treatment-for-consumption?popup=1

Medical Utiliy

The replication and the damage reparation are

essencial procces to the conservation of DNA, so damage in the structure could be reparated or modified to attack the

virus and microorganisms

providing to people quality life.

Medical Utiliy

Taken of http://www.vivirsalud.com/2010/06/23/7-habitos-de-personas-felices

Bibliography• Martínez Sánchez LM, Vargas Grisales N, Toro

Montoya AE, Pamplona Sierra AP, Quevedo Orrego E. Biología molecular. 6. ed. Medellín: UPB. Fac. de Medicina; 2011.

Newton J. A new generation of tuberculosis drugs. Royal Society of Chemestry; 2012.

Blocking DNA repair enzyme could eventually lead to cancer therapy. Science news line; 2012

THANKS!