Pigments
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Transcript of Pigments
PIGMENTSBY Dr Hasan AskariPATHOLOGY DEPARTMENT
PIGMENTS
Pigments are colored substance.
It may be exogenous & endogenous.
Exogenous coming from outside the body.
Endogenous synthesized within the body.
EXOGENOUS PIGMENTS
Carbon (coal dust),air pollutant & tattooing. Mechanism: Inhaled macrophages (alveoli) transported to
lymph node (tracheobronchial region). Black color of lungs (anthracosis) & lymph node. In coal miners carbon dust induce fibroblastic
reaction or emphysema coal worker’s pneumoconiosis.
Tattooing phagocytosis by dermal macrophages.
EXOGENOUS PIGMENTS
EXOGENOUS PIGMENTS
TATTOOS
TATTOO
EXOGENOUS PIGMENTS
ENDOGENOUS PIGMENTS
Lipofuscin (lipochrome or wear & tear pigment) Melanin Hemosiderin
ENDOGENOUS PIGMENTS
ENDOGENOUS PIGMENTSPIGMENTS
LIPOFUSCIN: • It is insoluble polymer of lipid & phospholipid with
protein by lipid peroxidation.• Yellow-brown color.• Not harmful.• It shows sign of free radical injury & lipid
peroxidation.• Mostly in liver & heart of aging, malnutrition &
cancer cachexia.
ENDOGENOUS PIGMENTSPIGMENTS
MELANIN:• It is endogenous , non-hemoglobin derived black –
brown pigment.• In melanocytes enzyme tyrosinase catalyze the
oxidation of tyrosine to dihydroxyphenylamine.• OCHRONOSIS: (Homogentisic acid)- Occur in patient with alkaptouria (metabolic
disorder)- Black pigment deposide in skin, connective tissue &
cartilage.
ENDOGENOUS PIGMENTS
EENDOGENOUS PIGMENTSNDOGENOUS PIGMENTS
HEMOSIDERIN:• Storage form of iron hemoglobin derived golden-
brown granular or crystalline pigment.• Iron transported by transferin stored in cell by
apoferrin form ferritin excess iron excess ferritin form hemosidrin granules.
• Normally seen in mononuclear phagocytes.• E.g: bruises
BRUISE
Just chill