Pharmacologic & Surgical Approaches Nancy F. Krebs, MD, MS, FAAP.
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Transcript of Pharmacologic & Surgical Approaches Nancy F. Krebs, MD, MS, FAAP.
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Pharmacologic & Surgical Approaches
Nancy F. Krebs, MD, MS, FAAP
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Pharmacologic Agents
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Pharmaco-therapy• For severely overweight children, the risk of
complications is great• Adjunctive therapy may be helpful in
achieving weight loss & in treating co-morbidities
• Must be used in conjunction with behavioral, dietary, and activity approaches
• Cost effectiveness: coverage for drugs, not for conservative measures?
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Use of Pharmacotherapy• Potential for significant adverse effects:
– Hypertension– Pulmonary hypertension– Psychological effects
• Currently available for pediatric use:– Sibutramine (Meridia)– Orlistat (Xenical)– (Metformin)
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Anorectic Agents: Limit food intakeAnorectic Agents: Limit food intake
• Should complement diet/exercise program
• Modest effects on total weight loss
• Variable responses (may reflect heterogeneity in etiology)
• Most benefit achieved within first 4 mo
• Regain of weight the norm when drug therapy stopped
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Sibutramine (Meridia)
Non-selective inhibitor of neuronal reuptake of serotonin and norepinephrine: appetite
suppressant
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SibutramineSibutramine
• Berkowitz et al. JAMA 289:1805, 2003
– 82 obese adolescents
(13-17 yr; BMI Z-score + 2.4)
– All received behavior (& diet) therapy
– Randomized to sibutramine vs. placebo
– 74 completed first 6 months, 62 completed 1 year) (after 6 mo, open label)
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Sibutramine + Behavior TherapySibutramine + Behavior Therapy
Weight Changes Mean ± SD Range Wt (kg) -7.8 ± 6.3 -23.8 - +1.2 BMI (%) -8.5 ± 6.8 -24.4 - +1.1
Modest & variable improvement of lipid
and insulin parameters
Berkowitz et al, JAMA ‘03
(p=0.001)
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Sibutramine -Side EffectsSibutramine -Side Effects
• 19/43 with mild hypertension and
tachycardia; 5 required discontinuation
• Other side effects
– Insomnia, anxiety, headache, depression, risk of serotonin syndrome in combination with other CNS drugs
– No data in absence of behavioral intervention
**FDA Approved for patients over age 16**FDA Approved for patients over age 16
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Orlistat (Xenical)
Pancreatic lipase inhibitor: fat malabsorption
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OrlistatOrlistat• Inhibits pancreatic lipase and increases fecal
fat losses
• 20 adolescents, BMI 44.1 ± 12.6, with at least one comorbidity; behavioral therapy + orlistat in open-label fashion x 3 mo
-4
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WeekMcDuffie, 2002
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Orlistat-Clinical TrialOrlistat-Clinical Trial
Inclusion criteria:• Male or female• 12–16 years• BMI: minimum 28.5 – 32 (age dependent)
Exclusion criteria:• BMI 44 kg/m2
• Body weight 130 kg or < 55 kg• Diabetes mellitus
539 subjects studied• all received lifestyle intervention• randomized to orlistat vs. placebo x 1 year
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Chanoine, J.-P. et al. JAMA 2005;293:2873-2883.
Change in Weight
Chanoine et al, JAMA, 2005(p=0.001)
Placebo
Orlistat
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Orlistat Orlistat Clinical Trial • Modest responses (+ 0.53 kg vs +3.14 kg at 1 yr);
slight BMI vs in placebo)
• Wt loss 5%: 26% vs 16%
• Wt loss 10%: 13% vs 4.5%
• Dropout rates ~ 1/3 both groups
• No significant differences in lipid profiles or glucose tolerance/insulin
• Weight loss associated w/ greater fat lossChanoine et al, JAMA, 2005
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Orlistat Clinical Trial• No apparent differences in response by sex or
ethnic/racial group• Side effects:
– no micronutrient (f.s. vit) deficiencies – GI Symptoms: 50% w/ fatty stools
29% w/ oily spotting to 8.5%
8.8% w/ fecal incontinence to 2.0%• Requires education of patients**FDA approved for children over age 12**FDA approved for children over age 12
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Metformin
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Metformin
hepatic gluconeogenesis and glucose production; hepatic insulin sensitivity
• Attenuates lipogenic state of hyperinsulinism
(obesity insulin resistance/hyperinsulinism) food intake fat stores (SQ > visceral?), improves lipid profiles• 25 % reduction in cumulative 3 yr incidence of
T2DM in adults; CV morbidity & mortality in adults w/ T2DM
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Metformin in Obese Adolescents
• Freemark et al. Pediatrics 107:e55, 2001
• 32 obese adolescents with insulin resistance and positive family history of T2DM (29 completed)
• Double-blind, randomized to metformin vs. placebo x 6 months
• No dietary restriction
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Metformin in Obese Adolescents
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Effect of Metformin on Insulin in 0bese Adolescents
Freemark et al. Pediatrics, 2001
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Metformin in Obese Adolescents
Side effects:• Transient abdominal discomfort or diarrhea
(< 1 mo)
• (Lactic acidosis (rare) in adults with chronic cardiac, hepatic, renal or GI disease)
• Urinary losses of B vitamins: use daily MVI in all metformin patients
• **Approved for Type 2 diabetes mellitus; not yet approved for obesity
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Metformin in Obese Adolescents
Remaining questions:
• Effects on weight (fat mass) loss w/ medication +/- lifestyle changes
• Effects on hyper/dys-lipidemia unclear
• Longer-term studies w/ larger “n” underway – safety & efficacy
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• Sibutramine: beware CV effects; acts on CNS
• Orlistat: highly motivated, h/o significant fat intake; GI effects may be limiting fx
• Metformin:
• obese adolescent with insulin resistance
• obesity due to psychotropic drugs ?
Summary: Medication ChoicesSummary: Medication Choices
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Summary - Medications• Additional (to behavioral + lifestyle Rx)
positive effect of medication is modest on average, substantial for some
• Reimbursement?– Lifestyle: often “no”– Medications: more likely?
• Access: medications vs (+/-) lifestyle
• Duration of treatment? Compliance?
• Predictors of optimal choice?
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Summary – MedicationsPediatric Nutrition Handbook (5th Ed):
“Drug therapy in children is not recommended…currently no Food and Drug Administration (FDA)-approved medications for use in children < 16 years of age.
“However, in some extremely obese adolescent patients with life-threatening morbidities, this approach may be necessary with the warning that…studies of the effectiveness of these drugs in children have not yet been reported.”
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Medication Quandry: Is the glass ½ full or ½ empty?
• Reserve meds for the “extreme” situation &/or use only as “experimental”?
or• View as part of the
armamentarium, knowing effect will be greater for some than others?
(e.g. –24% vs +1% BMI)
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Bariatric Surgery
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Rationale for Bariatric Surgery in Adolescents
• Persistence of pediatric obesity into adulthood – especially “extreme obesity” (BMI > 40, 200% IBW)
• Adolescents presenting with adult diseases, increased mortality
• Increases in obesity-related health care costs• Limited efficacy of behavioral (& pharmacologic)
approaches for the severely obese• Surgical weight loss ameliorates or resolves many
obesity related co-morbidities; durability of weight loss
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RYGB: Roux en-Y gastric bypass
BPD: Biliopancreatic diversion
GP: GastroplastyDS: Duodenal
switch
Number of bariatric surgeries, USA
1996-2001
Livingston. Am J Surg 2004
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Bariatric Surgery for Severely Overweight Adolescents:
Concerns and RecommendationsCriteria :
• Failed at least 6 months of organized weight management (as per PCP)
• Attained (or nearly) physiologic maturity
• BMI >40 with serious obesity-related comorbidity or BMI >50 with less severe comorbidities
Inge, et al. Pediatrics 114:217, 2004
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>30>30 >40>40 >50>50BMIBMI
YESYES
SeriousSeriousco-morbidity?co-morbidity?
NONO
Behavioral Behavioral ProgramProgram
““Consider”Consider”Bariatric SurgeryBariatric Surgery
Less SeriousLess Seriousco-morbidity?co-morbidity?
YESYES
NONO
Girls >13-14 Boys > 15-16
Bariatric Surgery for Severely Overweight Adolescents: Concerns and Recommendations
Inge, et al. Pediatrics 114:217, 2004
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Bariatric Surgery for Severely Overweight Adolescents: Concerns and Recommendations
Criteria (cont):• Commitment to comprehensive medical and
psychologic evaluations before and after surgery • Avoid pregnancy at least one year after surgery• Be capable and willing to adhere to nutritional
guidelines postoperatively• Provide informed assent to surgical treatment• Demonstrate decisional capacity• Have supportive family environment
Inge, et al. Pediatrics 114:217, 2004
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Timing of Surgical Treatment
• Sexual and skeletal maturation Sexual maturation- Tanner 3 or 4 Skeletal maturation –
age 13-14 y/o girls, 15-16 boys or have attained mid parental height
• Stage of cognitive development Acquired formal operations – thinking
about possibilities, consequences
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Psychological Evaluation
• Structured interview w/ adolescent psychologist
• Age appropriate objective testing to assess Personality traits Cognitive maturity Depression Eating behaviors Weight related quality of life
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Psychological Evaluation
• Contraindications substance abuse psychiatric disabilities including severe
eating disorders, mental impairment inability or unwillingness to follow
medical or nutritional recommendations or to maintain close long-term contact with health care providers
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Roux-en-Y Gastric Bypass
Inge, et al. Pediatrics 114:217, 2004
•Create 15-30 ml gastric pouch
•Gastrojejunostomy impairs rapid gastric emptying
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Advantages: Significant weight loss or lower BMI (~33%) one year post-op;
generally sustainable (14 year f/u) Deterrence to carbohydrate ingestion Enhanced satiety
Risks: Perioperative death (0.5%) (vs ABG: [.05%]) (adults) Other: intestinal leakage, thromboembolic disease, SBO, incisional
hernia, cholelithiasis, PCM Micronutrient deficiencies: Fe, Ca, B1, B12, folate Late deaths also reported (up to 6 years post-op) Late weight regain? (up to 15% of pts)
Roux-en-Y Gastric Bypass
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Bariatric Surgery: Experience Counts
1-19 cases; 6.2% mortality
20-85 cases; 0.73% mortality
86-220 cases; 0.37% mortality
•Surgeon experience and 30-day mortality for RYGP*
•Operative time, rates of leak & other complications after ~ 100 cases
*Flum, et al. J Amer Coll Surg, 2004
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Inge et al. J Pediatr Surg, 2004
Weight Loss Following RYGB
N=10 N=2N= 4
BMI
Adults: 14 yr f/u
-36%*
Adoles: 14 yr f/u
- 27%**
* Pories, 1995
** Sugarman, 2003
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Laparoscopic Adjustable Gastric BandLaparoscopic Adjustable Gastric Band
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Adjustable Gastric Banding
Inge, et al. Pediatrics 114:217, 2004
Placed laparoscopically; adjustable and removable
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Advantages: Minimally invasive placement (laparoscopic) Less nutrient effect compared with RNYGB Adjustable (by MD – encourages f/u) Removable
Disadvantages: ? Slower weight loss (max at 2-3 yr p-op) Finite lifetime (needs to be replaced) Long term results are unknown (only available for <10 years) Not yet approved by FDA for <18 y/o (not covered by insurance)
Adjustable Gastric Banding
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Comparison of Procedures
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Surgery Options ComparedSurgery Options Compared• RYGB
1-3 day LOS More extensive 1.5-3.5 hr operation Proven and favored
in U.S. Proven effective in
RCT 0.5% mortality* 17% morbidity*
• AGB 1 day LOS Less extensive 0.75-1.0 hr operation Favored worldwide;
new in the U.S Favorable results in
large case series 0.05% mortality* 7% morbidity*
* Comparisons from adults
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Surgical Outcomes (primarily based on adult data)
mortality: – Morbidly obese diabetic adults – 9 yr obs: 28% vs 9% w/o vs w/ bariatric surgery
• Improvement in dyslipidemia: 80% pts
• Hypertension: resolves 65%, improves 80%(may not be longstanding)
• T2DM: 75% pts remission; 85% pts disease burden
Obstructive sleep apnea• Psychological: depression, self concept/QOL
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Research Considerations & Future Directions
• Long-term outcomes of bariatric surgery in adolescents remain to be defined
• Risk/benefit & timing of intervention: earlier “correction” of metabolic derangements (how early is too early?)
• Future efforts directed at determination of physiologic mechanisms– alteration in appetite – feeding behavior– energy balance
Inge et al, J Peds, 2005
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Acknowledgements
• Mel Heyman, MD, FAAP
• Thomas Inge, MD• Many, many
colleagues!
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GG• 9-1/2 yr old girl, healthy• Cc: Parents:
– concern about ’g wt & effects on health
– Want pt to become more committed to health
• What is the problem?– “She loves food; watches food network
on cable, cookbooks, etc”– Pt: eating makes her “feel better”
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9 yr old GG
Diet hx:
Brk: 2 sl pizza + ice cream (2 scoops)
Lunch: double cheeseburger & fries
Dinner: hamburger, bun, 2 scoops of ice cream
Few limits; “doesn’t know when to stop eating”
Often skips lunch, eats through evening
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GGActivity history:• Competitive jump roping, soccer –
2-4x/wk• < 2 hr TV/d; computer < 1x/wk
PMHX: benign; h/o hyperlipidemia
FHx: BMI: Dad 26; Mom 22; + hx T2DM, obesity, hypertension, g.b. disease
SHx: dad in health care admin; mom home full time
ROS: mild joint c/o; o/w negative
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GG: School Aged Child
Girls: 2 to 20 years
BMI BMI
BMI BMI
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GG:Growth During
Infancy
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GG• Wt: 72 kg, Ht 146• Exam: positive acanthosis nigricans, o/w
unremarkable except for overweight status
• Assessment:– BMI = 33.7 (190% of ideal, c/w severe o.w.)
– At risk for insulin resistance, hyperlipidemia
– Multiple dietary problems• Excessive portion sizes
• Lack of structure/limits on eating
• High risk foods in household
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Setting the Agenda: A Joint Proposition
↓GrazingEat at table
ContinueSports Family
Meals
↓Portions
? ?
Food Choices
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GG: Recommendations• Diet & Eating
portions/size of breakfast (max 2-3 pancakes or 1 piece french toast;
– Eat only in the kitchen, w/ adult present– “Close the kitchen” between meals/snacks– Keep ice cream out of house
• Activity – continue soccer & jump rope
• Behavior– Kept “health calendar”– Weigh self q 2 wk (set a start date)
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GG: School Aged Child
Girls: 2 to 20 years
BMI BMI
BMI BMI
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Diet Control
• Stop all sugar beverages (soda AND juice)
Drink water and low fat milk
• Healthy snack = protein + fruit/veg (e.g. peanut butter and banana)
• Wait 20 min for second helpings
• Reduce TV time