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PHARMACODYNAMICS

MELBA GRACE T. DONIO, RN

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PHARMACODYNAMICS

IS A STUDY OF DRUG

CONCENTRATION AND ITSEFFECT ON THE BODY.

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HOW DRUGS WORK? Better assessment of ne mo!a"#t#es for

$s#n% !r$%s

Better assessment of ne #n!#&at#ons for!r$%s

Better assessment of ne &on&erns

re%ar!#n% r#s'()enef#t

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A#!s N$rse(Pat#ent Re"at#ons*#+

The patient has more respect for and trust in a therapist

who can convey to the patient how the drug is affecting the

patients body.

A patient who understands his/her therapy is more inclined

to become an active participant in the management

of the patients disease.

PEACE O, MIND-

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MECHANISM O, ACTION

Wa.s #n *#&* a !r$% &an +ro!$&e a

t*era+e$t#& effe&t

T*e effe&ts t*at a +art#&$"ar !r$% *as!e+en!s on t*e &e""s or or%an tar%ete! ).

t*e !r$%

On&e t*e !r$% *#ts #ts /s#te of a&t#on0 #t &an

mo!#f. t*e rate at *#&* a &e"" or t#ss$e

f$n&t#ons

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RECEPTOR INTERACTION

EN1YME INTERACTION

NON(SPECI,IC INTERACTION

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Drug Response2T*e re"at#ons*#+ )eteen t*em#n#ma" 3ers$s t*e ma4#ma" amo$nt of !r$% !ose

nee!e! to +ro!$&e t*e !es#re! !r$% res+onse5Onset of action

T*e t#me #t ta'es to rea&* t*e m#n#m$meffe&t#3e &on&entrat#on after t*e !r$% #s

a!m#n#stere!5Peak of action

O&&$rs *en t*e !r$% rea&*es #ts *#%*est)"oo! or +"asma &on&entrat#on5

Duration of action

Is t*e "en%t* of t#me t*e !r$% *as a +*arma&o"o%#&effe&t5

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CATEGORIES OF DRUG ACTION

1. STIU!ATION" t*e rate of &e"" a&t#3#t. or t*e

se&ret#ons from a %"an! #n&reases5 6e45 P#&roto4#n7

DEPRESSION" &e"" a&t#3#t. an! f$n&t#on of

s+ef#& or%an are re!$&e!. 6e45 Bar)#t$rates7#. REP!ACEENT" re+"a&e s$&* )o!. &om+o$n!s5

6e45 Ins$"#n7

$. IN%I&ITION" !r$%s t*at #n*#)#t or '#"" )a&ter#a" &e""

%rot* 6e45 Pen#""#n7

'. IRRITATION" !r$%s t*at &an a&t ). me&*an#sm of

#rr#tat#on 6e45 8a4at#3es7

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SIDE EFFECTS"ARE PHYSIO8OGIC E,,ECTS NOT

RE8ATED TO THE DESIRED DRUG E,,ECT5

AD(ERSE DRUG REACTION" MORE SE9ERE THAN

SIDE E,,ECTS5 THEY ARE RANGE O, UNTOWARD

E,,ECTS5 IT IS A8WAYS UNDESIRAB8E5

TO)ICIT*" WHEN A DRUG 8E9E8 E:CEEDS THE

THERAPEUTIC RANGE5 IT CAN BE IDENTI,IED BY

MONITORING THE P8ASMA SERUM5