Pharma Discovery Services - Eurofins Scientific · As a leader in safety pharmacology, Eurofins...
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human Q standard turnaround time ● agonist radioligand FAMILY ASSAY FORMAT ITEM # GPCR ADENOSINE A 2A ● 0004 ADRENERGIC alpha 1A 2338 alpha 2A 0013 beta 1 ● 0018 beta 2 ● 0020 CANNABINOID CB 1 ● 0036 CB 2 ● 0037 CHOLECYSTOKININ CCK 1 (CCK A ) ● 0039 DOPAMINE D 1 0044 D 2S ● 1322 ENDOTHELIN ET A ● 0054 HISTAMINE H 1 0870 H 2 1208 MUSCARINIC M 1 0091 M 2 0093 M 3 0095 OPIOID & OPIOID-LIKE delta 2 (DOP) ● 0114 kappa (KOP) ● 1971 mu (MOP) ● 0118 SEROTONIN 5-HT 1A ● 0131 5-HT 1B 0132 5-HT 2A ● 0471 5-HT 2B ● 1333 VASOPRESSIN V 1a ● 0159 TRANSPORTERS DOPAMINE dopamine transporter 0052 FAMILY ASSAY FORMAT ITEM # NOREPINEPHRINE norepinephrine transporter 0355 SEROTONIN 5-HT transporter 0439 ION CHANNELS GABA CHANNELS BZD (central) ● 0028 GLUTAMATE CHANNELS NMDA 0066 NICOTINIC CHANNELS N neuronal α4β2 ● 3029 SEROTONIN CHANNELS 5-HT 3 0411 Ca 2+ CHANNELS Ca 2+ channel (L, dihydropyridine site) 0161 K + CHANNELS hERG (membrane preparation) 1868 K V channel 0166 Na + CHANNELS Na + channel (site 2) 0169 NUCLEAR RECEPTORS STEROID NUCLEAR RECEPTORS AR ● 0933 GR ● 0469 KINASES CTK Lck kinase 2906 OTHER NON-KINASE ENZYMES AA METABOLISM COX 1 0726 COX 2 0727 MONOAMINE & NEUROTRANSMITTER acetylcholinesterase 0363 MAO-A 0443 PHOSPHODIESTERASES PDE3A 2432 PDE4D2 2434 SafetyScreen44 ™ Panel As a leader in safety pharmacology, Eurofins Pharma Discovery Services offers the SafetyScreen44™ panel to enable early identification of significant off-target interactions with your compound. All 44 selected targets, recommended by 4 major pharmaceutical companies (Bowes et al. 2012), are gathered in a cost-effective panel that brings together both robustness (each assay is HTS-compatible) and the strategic choice of information-rich targets. Ref. P270 Suggested testing: 10 µM (n=2) Q 10 business days Pharma Discovery Services Eurofins, SafetyScreen44 and the logo are trademarks of Eurofins. Lit No. EPDSFL420JUNE16. Printed in France and USA. Copyright © 2016 Eurofins Cerep S.A. Eurofins Pharma Discovery Services, Eurofins Cerep Panlabs and Eurofins Discovery Services are brands of Eurofins Pharma Discovery Services division. Eurofins Panlabs, Inc., Eurofins Panlabs Taiwan, Ltd., Eurofins Cerep S.A., Eurofins Pharma Bioanalytics Services US Inc. and Eurofins Pharma Discovery Services UK Ltd are independent members of Eurofins Pharma Discovery Services. For more information visit: eurofins.com/epds Eurofins Panlabs, Inc 15 Research Park Drive St Charles, MO 63304 USA T l +1 (844) 522 7787 F l +1 (636) 362 7131 E l discoveryservices@eurofins.com Eurofins Pharma Discovery Services UK, Ltd. Gemini Crescent, Dundee Technology Park Dundee, DD2 1SW UNITED KINGDOM T l +44 1382 561600 F l +44 1382 561601 E l discoveryservices@eurofins.com Eurofins Cerep SA Le bois l’Evêque 86600 Celle l’Evescault FRANCE T l +33 (0)5 49 89 30 00 F l +33 (0)5 49 43 21 70 E l cereppanlabs@eurofins.com Eurofins Panlabs Taiwan, Ltd. No. 158 Li Teh Road, Peitou Taipei, 11259 TAIWAN T l +886 2 2898 7888 F l +886 2 2894 8267 E l discoveryservices@eurofins.com
Transcript of Pharma Discovery Services - Eurofins Scientific · As a leader in safety pharmacology, Eurofins...
human Q standard turnaround time ● agonist radioligand
FAMILY ASSAY FORMAT ITEM # GPCR ADENOSINE A2A ● 0004 ADRENERGIC alpha1A 2338
alpha2A 0013beta1 ● 0018beta2 ● 0020
CANNABINOID CB1 ● 0036CB2 ● 0037
CHOLECYSTOKININ CCK1 (CCKA) ● 0039 DOPAMINE D1 0044
D2S ● 1322 ENDOTHELIN ETA ● 0054 HISTAMINE H1 0870
H2 1208 MUSCARINIC M1 0091
M2 0093M3 0095
OPIOID & OPIOID-LIKE delta2 (DOP) ● 0114kappa (KOP) ● 1971mu (MOP) ● 0118
SEROTONIN 5-HT1A ● 01315-HT1B 01325-HT2A ● 04715-HT2B ● 1333
VASOPRESSIN V1a ● 0159
TRANSPORTERS DOPAMINE dopamine
transporter0052
FAMILY ASSAY FORMAT ITEM # NOREPINEPHRINE norepinephrine
transporter0355
SEROTONIN 5-HT transporter 0439
ION CHANNELS GABA CHANNELS BZD (central) ● 0028 GLUTAMATE CHANNELS NMDA 0066 NICOTINIC CHANNELS N neuronal α4β2 ● 3029 SEROTONIN CHANNELS 5-HT3 0411 Ca2+ CHANNELS Ca2+ channel
(L, dihydropyridine site)0161
K+ CHANNELS hERG (membrane preparation)
1868
KV channel 0166 Na+ CHANNELS Na+ channel (site 2) 0169
NUCLEAR RECEPTORS STEROID NUCLEAR RECEPTORS
AR ● 0933GR ● 0469
KINASES CTK Lck kinase 2906
OTHER NON-KINASE ENZYMES AA METABOLISM COX1 0726
COX2 0727 MONOAMINE & NEUROTRANSMITTER
acetylcholinesterase 0363MAO-A 0443
PHOSPHODIESTERASES PDE3A 2432PDE4D2 2434
SafetyScreen44™ PanelAs a leader in safety pharmacology, Eurofins Pharma Discovery Services offers the SafetyScreen44™ panel to enable early identification of significant off-target interactions with your compound. All 44 selected targets, recommended by 4 major pharmaceutical companies (Bowes et al. 2012), are gathered in a cost-effective panel that brings together both robustness (each assay is HTS-compatible) and the strategic choice of information-rich targets.
Ref. P270
Suggested testing: 10 µM (n=2)
Q 10 business days
PharmaDiscovery Services
Eurofins, SafetyScreen44 and the logo are trademarks of Eurofins. Lit No. EPDSFL420JUNE16. Printed in France and USA. Copyright © 2016 Eurofins Cerep S.A. Eurofins Pharma Discovery Services, Eurofins Cerep Panlabs and Eurofins Discovery Services are brands of Eurofins Pharma Discovery Services division. Eurofins Panlabs, Inc., Eurofins Panlabs Taiwan, Ltd., Eurofins Cerep S.A., Eurofins Pharma Bioanalytics Services US Inc. and Eurofins Pharma Discovery Services UK Ltd are independent members of Eurofins Pharma Discovery Services.
For more information visit: eurofins.com/epds
Eurofins Panlabs, Inc
15 Research Park Drive
St Charles, MO 63304
USAT l +1 (844) 522 7787
F l +1 (636) 362 7131
Eurofins Pharma Discovery
Services UK, Ltd.
Gemini Crescent, Dundee Technology ParkDundee, DD2 1SWUNITED KINGDOMT l +44 1382 561600F l +44 1382 561601E l [email protected]
Eurofins Cerep SA
Le bois l’Evêque
86600 Celle l’Evescault
FRANCET l +33 (0)5 49 89 30 00
F l +33 (0)5 49 43 21 70
Eurofins Panlabs Taiwan, Ltd.No. 158 Li Teh Road, Peitou
Taipei, 11259
TAIWANT l +886 2 2898 7888
F l +886 2 2894 8267
