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Presentation by shalini kumari,product manager,Hyderabad on Triclofos8978600746
Transcript of Pednap
SleepSleep
Sleep is a state of unconsciousness in which the brain is relatively more responsive to internal than to external stimuli.
Sleep is a state of unconsciousness in which the brain is relatively more responsive to internal than to external stimuli.
Sleep through out life
Sleep through out life
Why do we sleep?Why do we sleep?
To support normal levels of cognitive skills such as
Speech
memory
innovative and flexible thinking.
Very Important for brain development.
For Concentration
For Physical and Emotional fitness
To support normal levels of cognitive skills such as
Speech
memory
innovative and flexible thinking.
Very Important for brain development.
For Concentration
For Physical and Emotional fitness
Average Sleep Needs
Average Sleep Needs
Average Sleep Needs
Age Hours
Newborns (0-2 months) 12-18
Infants (3 months to 1 year) 14 - 15
Toddlers (1 to 3 years) 12-14
Preschoolers (3 to 5 years) 11-13
School-aged children (5 to 12 years) 10-11
Teens and preteens (12 to 18 years) 8.5 - 10
Adults (18+) 7.5 - 9
Sleep CycleSleep Cycle
Sleep is divided into two broad types: rapid eye
movement (REM) and non-rapid eye movement (NREM or
non-REM) sleep.
Each type has a distinct set of associated physiological,
neurological, and psychological features.
Sleep is divided into two broad types: rapid eye
movement (REM) and non-rapid eye movement (NREM or
non-REM) sleep.
Each type has a distinct set of associated physiological,
neurological, and psychological features.
Sleep pattern in children
Sleep pattern in children
Baby sleep cycles are far shorter than those of
adults
Babies spend more time in rapid eye movement
(REM) sleep, which is thought to be necessary for
the extraordinary development happening in their
brain.
REM sleep is lighter than non-REM sleep, and more
easily disrupted.
Baby sleep cycles are far shorter than those of
adults
Babies spend more time in rapid eye movement
(REM) sleep, which is thought to be necessary for
the extraordinary development happening in their
brain.
REM sleep is lighter than non-REM sleep, and more
easily disrupted.
Insomnia is defined as difficulty with the initiation,
maintenance, duration, or quality of sleep that results in
the impairment of daytime functioning, despite adequate
opportunity and circumstances for sleep.
Patient’s subjective dissatisfaction with the sleep
quality and quantity
Insomnia is defined as difficulty with the initiation,
maintenance, duration, or quality of sleep that results in
the impairment of daytime functioning, despite adequate
opportunity and circumstances for sleep.
Patient’s subjective dissatisfaction with the sleep
quality and quantity
Insomnia
Causes of Insomnia in Children
Causes of Insomnia in Children
Teething
fretfulness
repeated indigestion with persistent
crying
Excitability and restlessness
Difficult feeding
Disruption of sleep patterns
Teething
fretfulness
repeated indigestion with persistent
crying
Excitability and restlessness
Difficult feeding
Disruption of sleep patterns
Treatment of Insomnia
Treatment of Insomnia
Commonly prescribed off-label to treat
pediatric patients with insomnia
including alpha agonists e.g. Clonidine,
Guanfacine
Trazodone
Benzodiazepines and
Newer sedatives/hypnotics such as Non
benzodiazepines as Zolpidem,
Eszopiclone and Triclofos etc. .
Commonly prescribed off-label to treat
pediatric patients with insomnia
including alpha agonists e.g. Clonidine,
Guanfacine
Trazodone
Benzodiazepines and
Newer sedatives/hypnotics such as Non
benzodiazepines as Zolpidem,
Eszopiclone and Triclofos etc. .
Side Effects with Other Drugs
Side Effects with Other Drugs
Narrow therapeutic window
A high risk for cardiovascular toxicity
Risks of physical dependence
Rebound insomnia
Cause unpredictable excitation in younger children.
Narrow therapeutic window
A high risk for cardiovascular toxicity
Risks of physical dependence
Rebound insomnia
Cause unpredictable excitation in younger children.
Triclofos sodiumTriclofos sodium
Introducing
TriclofosTriclofos
A sedative drug used for treating insomnia,
usually as a second-line treatment after other
drugs have failed.
Belongs to category of potentiates the cns
depressants like sedative, barbiturates drugs.
Well tolerated & effective non barbiturate sleep
promoting agent conspicuously free from tendency
to cause ‘hang over’ & other side effects.
A sedative drug used for treating insomnia,
usually as a second-line treatment after other
drugs have failed.
Belongs to category of potentiates the cns
depressants like sedative, barbiturates drugs.
Well tolerated & effective non barbiturate sleep
promoting agent conspicuously free from tendency
to cause ‘hang over’ & other side effects.
TriclofosTriclofos
Triclofos is a prodrug which is
metabolized in the liver into the active
drug trichloroethanol which acts as a
sedative.
Triclofos is a prodrug which is
metabolized in the liver into the active
drug trichloroethanol which acts as a
sedative.
Why PednapWhy Pednap
Drug of Natural origin
Very safe for children below 5 yrs
It is a well tolerated & effective non barbiturate
sleep promoting agent conspicuously free from
tendency to cause 'hang over' and other side
effects.
Triclofos decreases the time taken to fall
asleep and increases the length of time spent
sleeping.
Drug of Natural origin
Very safe for children below 5 yrs
It is a well tolerated & effective non barbiturate
sleep promoting agent conspicuously free from
tendency to cause 'hang over' and other side
effects.
Triclofos decreases the time taken to fall
asleep and increases the length of time spent
sleeping.
More palatable.
Causes less gastric irritation.
Less Respiratory rate Fluctuations.
Fewer G.I side effects.
More palatable.
Causes less gastric irritation.
Less Respiratory rate Fluctuations.
Fewer G.I side effects.
Target CustomersTarget Customers
Pediatricians Physicians
Pediatricians Physicians
Brand Name
Company CompositionPackagin
g (BOTTLE)
Price per
Strip
SLEP SALUD TRICLOFOS SODIUM 30ML 38
PEDICRORYL DR REDDY TRICLOFOS SODIUM 30ML 44.50
TRYCLORYL GLAXO TRICLOFOS SODIUM 60ML 38.00
SNOOZ MAXX INDIA TRICLOFOS 30ML 55
FOSKIDEAST
AFRICANTRICLOFOS SODIUM 30ML 28
Competition – Pednap
The EndThe End
