Pathophysiology, Special Considerations, and...

A Case of Scoliosis Repair: Pathophysiology, Special Considerations,

and Intraoperative Management

A Case of Scoliosis Repair: Pathophysiology, Special Considerations,

and Intraoperative Management

Karim Rafaat, M.D.Karim Rafaat, M.D.

OutlineOutline

Case presentation Overview of diagnostic/treatment

considerations Intraoperative management

Case presentation Overview of diagnostic/treatment

considerations Intraoperative management

Case PresentationCase Presentation

Karim Rafaat, M.D.

Fellow in Pediatric AnesthesiaLucile Packard Children’s Hospital

Stanford University

Karim Rafaat, M.D.

Fellow in Pediatric AnesthesiaLucile Packard Children’s Hospital

Stanford University

Case Report:C.C.Case Report:C.C.

IdentificationIdentification

12 yo male with complex medical history

Scheduled for posterior spinal instrumentation and fusion with multiple vertebrectomies

12 yo male with complex medical history

Scheduled for posterior spinal instrumentation and fusion with multiple vertebrectomies

Past Medical HistoryPast Medical History

Midthoracic Myelomeningocele -repaired as an infant in Mexico

paralysis to T6Chiari II malformationHydrocephalus, s/p VP Shunt placementDevelopmental DelayScoliosis

Midthoracic Myelomeningocele -repaired as an infant in Mexico

paralysis to T6Chiari II malformationHydrocephalus, s/p VP Shunt placementDevelopmental DelayScoliosis

Past Medical HistoryPast Medical History

Failure to ThriveSeizuresFailure to ThriveSeizures

Past Surgical HistoryPast Surgical History

Per mother’s report, has had over 30 surgeries: Repair of midthoracic myelomeningoceleVP Shunt, s/p multiple revisionsUrostomyVentral hernia repairBilat ear tubesG-tube placement

Per mother’s report, has had over 30 surgeries: Repair of midthoracic myelomeningoceleVP Shunt, s/p multiple revisionsUrostomyVentral hernia repairBilat ear tubesG-tube placement

Birth/Developmental HistoryBirth/Developmental History

Born at 32 wksWheelchair dependent

Cannot standUrostomy - incontinent of urineIncontinent of stoolSensory level approximately at umbilicus

Born at 32 wksWheelchair dependent

Cannot standUrostomy - incontinent of urineIncontinent of stoolSensory level approximately at umbilicus

Family HistoryFamily History

Negative for any bleeding problemsNegative for any problems with anesthesia

Negative for any bleeding problemsNegative for any problems with anesthesia

MedicationsMedications

Phenobarbital 15mg per G-tube bidNitrofurantoin 3mg per G-tube bidPhenobarbital 15mg per G-tube bidNitrofurantoin 3mg per G-tube bid

Physical ExamPhysical Exam

Vital Signs:T - 36.8 CHR - 90BP - 122/85RR - 20SpO2 - 99% on RA

Vital Signs:T - 36.8 CHR - 90BP - 122/85RR - 20SpO2 - 99% on RA


Weight 20.3 KgGeneral - seated in wheelchair, NAD, interactive and pleasantHEENT - Macrocephalic with multiple surgical scars over scalpAirway - MP 1, good thyromental distance, good mandibular mobility, short, stiff neck

Weight 20.3 KgGeneral - seated in wheelchair, NAD, interactive and pleasantHEENT - Macrocephalic with multiple surgical scars over scalpAirway - MP 1, good thyromental distance, good mandibular mobility, short, stiff neck


Pulmonary - severe scoliosis, BS decreased over R, o/w clearCV - RRR, no m/r/gAbdomen - G-Tube. Normal bowel soundsMusculoskeletal - very pronounced scoliotic curve. Curve is rigid and does not move with bendingNeuro - No sensation below umbilicus. No lower extremity motor function

Pulmonary - severe scoliosis, BS decreased over R, o/w clearCV - RRR, no m/r/gAbdomen - G-Tube. Normal bowel soundsMusculoskeletal - very pronounced scoliotic curve. Curve is rigid and does not move with bendingNeuro - No sensation below umbilicus. No lower extremity motor function

The Cobb AngleThe Cobb Angle

LabsLabs

Chem 7 - wnlCBC - Hct 43Coags - wnl

Chem 7 - wnlCBC - Hct 43Coags - wnl

OperationOperation

Consisted of:Vertebrectomy T12-L1Spinal cord excision below T12Posterior spinal instrumentation and fusion T1-S1

Consisted of:Vertebrectomy T12-L1Spinal cord excision below T12Posterior spinal instrumentation and fusion T1-S1

Intraoperative CourseIntraoperative Course

Intubated easily with 5.0 cuffed ETT and MAC blade3 PIV’s total: 1x22G, 2x20GRadial A-lineRIJ 5Fr double lumen central catheter

Intubated easily with 5.0 cuffed ETT and MAC blade3 PIV’s total: 1x22G, 2x20GRadial A-lineRIJ 5Fr double lumen central catheter


Amicar bolus 75mg/kg, drip at 75 mg/kg/hrLungs with reasonable compliance (!) and no difficulties with gas exchangeStable hemodynamics (when surgical losses properly attended to)Stable UOPPersistent and significant bleeding from bony surgical sites

Amicar bolus 75mg/kg, drip at 75 mg/kg/hrLungs with reasonable compliance (!) and no difficulties with gas exchangeStable hemodynamics (when surgical losses properly attended to)Stable UOPPersistent and significant bleeding from bony surgical sites


Operative course stable (with some effort), with no unexpected complications until......

Operative course stable (with some effort), with no unexpected complications until......

Guess What’s Missing..........Guess What’s Missing..........

The spinal cord was incised and excised below T12The spinal cord was incised and excised below T12


Acute spinal shock manifested as sudden hypotension, unresponsive to fluidsNeosynephrine bolused frequently, while drip prepared

Dose ranged from 0.1 - 2 mcg/kg/min

Vasopressin drip startedDose ranged from 0.2 - 1.2 units/hrUsual shock dose 10-50 mU/kg/hr

Acute spinal shock manifested as sudden hypotension, unresponsive to fluidsNeosynephrine bolused frequently, while drip prepared

Dose ranged from 0.1 - 2 mcg/kg/min

Vasopressin drip startedDose ranged from 0.2 - 1.2 units/hrUsual shock dose 10-50 mU/kg/hr


Volatiles reduced, and midazolam bolused to ensure amnesiaDespite mild, persistent hypotension (MAPs in 50s, with visits to the 40s), sufficient end-organ oxygen delivery maintained as evidenced by continued UOP > 0.5 cc/kg/hr and lack of a base deficit on ABG

Volatiles reduced, and midazolam bolused to ensure amnesiaDespite mild, persistent hypotension (MAPs in 50s, with visits to the 40s), sufficient end-organ oxygen delivery maintained as evidenced by continued UOP > 0.5 cc/kg/hr and lack of a base deficit on ABG


Case ended smoothly, secondary to consistent leg work

1200 cc crystalloids250cc colloids6 units PRBC, 2 units FFP, 1 unit PlatletsAforementioned pressors, plus boluses

Case ended smoothly, secondary to consistent leg work

1200 cc crystalloids250cc colloids6 units PRBC, 2 units FFP, 1 unit PlatletsAforementioned pressors, plus boluses

Brief Post-Op CourseBrief Post-Op Course

Pt admitted to PICU on 0.5 mcg/kg/min Neosynephrine and 1 unit/hr VasopressinHct 30 with Coags wnlPressors off by next morning Extubated that same day to NCDischarged home after 5 days

Pt admitted to PICU on 0.5 mcg/kg/min Neosynephrine and 1 unit/hr VasopressinHct 30 with Coags wnlPressors off by next morning Extubated that same day to NCDischarged home after 5 days

Bilateral lung Fields visible!Bilateral lung Fields visible!

Scoliosis: An OverviewScoliosis: An Overview

OutlineOutline

Definition Etiology Associated co-morbidities Conservative treatment Indications for surgery Predictors of complications

Definition Etiology Associated co-morbidities Conservative treatment Indications for surgery Predictors of complications

DefinitionDefinition

A lateral spinal curvature of >10º ~2% of children affected at some stage

of life ~10% of affected patients will require

corrective surgery

A lateral spinal curvature of >10º ~2% of children affected at some stage

of life ~10% of affected patients will require

corrective surgery

Plain Radiographs of the Spine in Two Children With Idiopathic Scoliosis

Musson et al., Postgrad Med J 2010.

The Cobb AngleThe Cobb Angle Line across top of

cephalad and bottom of caudad vertebrae that are maximally displaced

Perpendiculars from these two lines are intersected

Angle between perpendiculars = Cobb Angle

Line across top of cephalad and bottom of caudad vertebrae that are maximally displaced

Perpendiculars from these two lines are intersected

Angle between perpendiculars = Cobb Angle

http://www.pediatriceducation.org/2006/12/11/

Idiopathic ScoliosisIdiopathic ScoliosisMost common ~70% of all cases Infantile, juvenile, or adolescent forms Exact cause unknown, but many

contributing factors identifiedCollagen abnormalities Abnormal growthHormonal abnormalities Possible genetic basis with incomplete

penetrance may explain female predominance

Most common ~70% of all cases Infantile, juvenile, or adolescent forms Exact cause unknown, but many

contributing factors identifiedCollagen abnormalities Abnormal growthHormonal abnormalities Possible genetic basis with incomplete

penetrance may explain female predominance

Musson et al., Postgrad Med J 2010.

Other EtiologiesOther Etiologies Congenital

Osteogenic - vertebral anomalies Neuropathic - tethered cord, myelomeningocele

Neuromuscular Neuropathic - cerebral palsy, polio Myopathic - Duchenne muscular dystrophy

Developmental Dysplasia Neurofibromatosis Tumor-associated

Vertebral/Intraspinal Infection

Congenital Osteogenic - vertebral anomalies Neuropathic - tethered cord, myelomeningocele

Neuromuscular Neuropathic - cerebral palsy, polio Myopathic - Duchenne muscular dystrophy

Developmental Dysplasia Neurofibromatosis Tumor-associated

Vertebral/Intraspinal Infection

Pulmonary ComorbiditiesPulmonary Comorbidities

Restrictive lung pattern Decrease in lung volumes Vital capacity most significant FRC, TLC, IC, ERV also

Impaired respiratory muscle functionChest wall deformity = inspiratory muscles

working at mechanical disadvantage Arterial hypoxemia from V/Q mismatch

Restrictive lung pattern Decrease in lung volumes Vital capacity most significant FRC, TLC, IC, ERV also

Impaired respiratory muscle functionChest wall deformity = inspiratory muscles

working at mechanical disadvantage Arterial hypoxemia from V/Q mismatch

Pulmonary ComorbiditiesPulmonary Comorbidities

Slope of ventilatory response to CO2may be decreased

Higher respiratory rates and lower tidal volumes minimize work of breathing

Pulmonary compromise increases with curve progression

Slope of ventilatory response to CO2may be decreased

Higher respiratory rates and lower tidal volumes minimize work of breathing

Pulmonary compromise increases with curve progression

Cardiac ComorbiditiesCardiac Comorbidities

Chronic hypoxemia HPV Pulmonary Hypertension

RVH RV failureMVP common among scoliosis patients Scoliosis associated with congenital

heart disease (no specific lesion)

Chronic hypoxemia HPV Pulmonary Hypertension

RVH RV failureMVP common among scoliosis patients Scoliosis associated with congenital

heart disease (no specific lesion)

Natural HistoryNatural History

Significant curve progression may eventually lead to intolerable cardiopulmonary compromise

Treatment is either conservative (aimed at slowing/stopping curve progression) or surgical

Significant curve progression may eventually lead to intolerable cardiopulmonary compromise

Treatment is either conservative (aimed at slowing/stopping curve progression) or surgical

Examples of Braces Used in Scoliosis Treatment

Sponseller PD. J Pediatr Orthop 2011.

Conservative ManagementConservative Management

Bracing is the mainstay of treatment Goal = slow or prevent curve

progression via external forces guiding growth of spine

Curve correction with bracing is not commonly observed

Bracing is the mainstay of treatment Goal = slow or prevent curve

progression via external forces guiding growth of spine

Curve correction with bracing is not commonly observed

Indications for BracingIndications for Bracing

Curve of 25-45º in patient going through a rapid growth period (Risser 0-1 years)

Some patients with smaller curves showing recent progression

Curve of 25-45º in patient going through a rapid growth period (Risser 0-1 years)

Some patients with smaller curves showing recent progression


Characteristics Predicting Failure of Bracing TreatmentCharacteristics Predicting Failure of Bracing Treatment

Overweight High thoracic curve (above T8) Lordotic thoracic spineWithin a year of skeletal maturity 1-year post-menarche Treatment non-compliance

Overweight High thoracic curve (above T8) Lordotic thoracic spineWithin a year of skeletal maturity 1-year post-menarche Treatment non-compliance


Indications for Surgical TreatmentIndications for Surgical Treatment

Cobb Angle >50º Cobb Angle >40º in skeletally immature

patient Progression of scoliosis in spite of

bracing “Unacceptable” (cosmetically or

functionally) deformity

Cobb Angle >50º Cobb Angle >40º in skeletally immature

patient Progression of scoliosis in spite of

bracing “Unacceptable” (cosmetically or

functionally) deformity

Bridwell KH, Spine 1999.

Risk Factors for Postoperative Complications Risk Factors for Postoperative Complications Etiology of scoliosis

Neuromuscular pts have higher surgical complication rates (17.9%) vs congenital (10.6%) or idiopathic scoliosis (6.3%) - higher mortality, increased LOS, increased costs

Respiratory, cardiac, transfusion-related complications predominate

Anticonvulsant use VPA, phenytoin, phenobarbital associated with

greater EBL, more transfusions

Etiology of scoliosis Neuromuscular pts have higher surgical

complication rates (17.9%) vs congenital (10.6%) or idiopathic scoliosis (6.3%) - higher mortality, increased LOS, increased costs

Respiratory, cardiac, transfusion-related complications predominate

Anticonvulsant use VPA, phenytoin, phenobarbital associated with

greater EBL, more transfusions

Erickson MA and Baulesh DM. Curr Opin Pediatr 2011.

Risk Factors for Postoperative ComplicationsRisk Factors for Postoperative Complications Pulmonary status Poor baseline function predicts

complications/need for postop ventilation Frequent PNA, inability to handle

secretions, prolonged desaturation during sleep, lung damage/fibrosis are red flags preoperatively

Cardiac status Be mindful of congenital heart disease and

pulmonary hypertension

Pulmonary status Poor baseline function predicts

complications/need for postop ventilation Frequent PNA, inability to handle

secretions, prolonged desaturation during sleep, lung damage/fibrosis are red flags preoperatively

Cardiac status Be mindful of congenital heart disease and

pulmonary hypertension


Risk Factors for Postoperative ComplicationsRisk Factors for Postoperative Complications

Nutritional statusDelayed wound healing and greater

susceptibility to infection Immune status Increased infection risk if compromised

Social considerations Postoperative care needs can be intense

so suitability of home environment/caregivers must be assessed

Nutritional statusDelayed wound healing and greater

susceptibility to infection Immune status Increased infection risk if compromised

Social considerations Postoperative care needs can be intense

so suitability of home environment/caregivers must be assessed


Surgical ConsiderationsSurgical Considerations

Bigger surgery = more complications Anterior posterior spinal fusion associated

with longer operative times, more EBL, more transfusion, more pulmonary complications than anterior or posterior fusion alone

Rule of 6 if operative time is longer than 6h, or if more than

6 levels fused, complication risk is higher

Bigger surgery = more complications Anterior posterior spinal fusion associated

with longer operative times, more EBL, more transfusion, more pulmonary complications than anterior or posterior fusion alone

Rule of 6 if operative time is longer than 6h, or if more than

6 levels fused, complication risk is higher


SummarySummary

Definition and Etiology Cobb Angle Comorbidities Bracing Risk factors for complications

Definition and Etiology Cobb Angle Comorbidities Bracing Risk factors for complications

ReferencesReferences

Bridwell KH. Surgical treatment of idiopathic adolescent scoliosis. Spine 1999; 24: 2607-16.

Erickson MA, Baulesh DM. Pathways that distinguish simple from complex scoliosis repair and their outcomes. Curr Opin Pediatr 2011; 23: 339-45.

Musson RE et al. Imaging in childhood scoliosis: a pictorial review. Postgrad Med J 2010; 86: 419-27.

Sponseller PD. Journal of Pediatric Orthopaedics 2011; 31: S53-S60.

Zayas VM. “Scoliosis” in Anethesiology: Problem-Oriented Patient Management. Yao et al. Eds. 2008; Lippincott Williams & Wilkins.

http://www.pediatriceducation.org/2006/12/11/

Intraoperative ManagementIntraoperative Management

OutlineOutline

Airway management Access and monitors Prone positioning Anesthesia and neurophysiologic

monitoring Transfusion management Postoperative pain managementManagement of spinal shock

Airway management Access and monitors Prone positioning Anesthesia and neurophysiologic

monitoring Transfusion management Postoperative pain managementManagement of spinal shock

Airway evaluationAirway evaluation

Assessment of cervical spine stability (Chiari II malformation) flexion of the neck may cause compression of the

medulla1

Assessment of any coexisting craniofacial abnormalities

Implications for mask ventilation and intubation: is the patient is a difficult airway? what is the primary plan for airway management? what are the backup plans in case the primary

plan fails?

Assessment of cervical spine stability (Chiari II malformation) flexion of the neck may cause compression of the

medulla1

Assessment of any coexisting craniofacial abnormalities

Implications for mask ventilation and intubation: is the patient is a difficult airway? what is the primary plan for airway management? what are the backup plans in case the primary

plan fails?

Positioning during inductionPositioning during induction

Patient positioning during induction and airway management: can the patient be laid supine? (severe

kyphosis/meningomyelocele) lateral or semi-lateral induction and airway

management may be necessary

Patient positioning during induction and airway management: can the patient be laid supine? (severe

kyphosis/meningomyelocele) lateral or semi-lateral induction and airway

management may be necessary

Access and monitorsAccess and monitors

Access in addition to large bore peripheral access,

consider central access for patients with anticipated increased bleeding risk

Monitoring In addition to standard ASA monitors, CVP as a

monitor for trending volume status Arterial line as a close monitor of hemodynamic

changes with the ability to sample blood gases for Hct, assessment of acid base status, etc.

Access in addition to large bore peripheral access,

consider central access for patients with anticipated increased bleeding risk

Monitoring In addition to standard ASA monitors, CVP as a

monitor for trending volume status Arterial line as a close monitor of hemodynamic

changes with the ability to sample blood gases for Hct, assessment of acid base status, etc.

Intraoperative prone positioning1,2Intraoperative prone positioning1,2

Sources of morbidity in the prone position Facial compression, ocular injury -> loss of vision/blindness Neck/cord injury from excessive extension or flexion Inadequate intraabominal excursion leading to impaired

ventilation and increased venous pressure (more bleeding) Brachial plexus injury from excessive extension (greater than

90 degrees) Femoral nerve injury from compression by bolsters

Tape ETT securely Frequent checks of eyes, face, airway, and neck

positioning

Sources of morbidity in the prone position Facial compression, ocular injury -> loss of vision/blindness Neck/cord injury from excessive extension or flexion Inadequate intraabominal excursion leading to impaired

ventilation and increased venous pressure (more bleeding) Brachial plexus injury from excessive extension (greater than

90 degrees) Femoral nerve injury from compression by bolsters

Tape ETT securely Frequent checks of eyes, face, airway, and neck

positioning

Intraoperative managementIntraoperative management

If the airway is unexpectedly lost in the prone position, what is the plan for reacquiring airway control? Plan for supporting oxygenation and

ventilation in the prone position Expeditious turning of patient to supine

position (proximity of OR stretcher) Plan for reintubation

If the airway is unexpectedly lost in the prone position, what is the plan for reacquiring airway control? Plan for supporting oxygenation and

ventilation in the prone position Expeditious turning of patient to supine

position (proximity of OR stretcher) Plan for reintubation

Intraoperative anesthetic managementIntraoperative anesthetic management Stable, balanced anesthetic consisting of

volatiles and intravenous infusions to provide satisfactory and consistent conditions for neurophysiologic monitoring

Avoid large boluses or sudden changes in anesthetic

Communication with neurophysiologist Backup anesthetic plans in the event of

hemodynamic instability (conversion to more cardiostable medications i.e. ketamine)

Stable, balanced anesthetic consisting of volatiles and intravenous infusions to provide satisfactory and consistent conditions for neurophysiologic monitoring

Avoid large boluses or sudden changes in anesthetic

Communication with neurophysiologist Backup anesthetic plans in the event of

hemodynamic instability (conversion to more cardiostable medications i.e. ketamine)

Anesthetic effects on SSEPs and MEPs2,3Anesthetic effects on SSEPs and MEPs2,3

All anesthetics affect spinal monitoring to varying degrees

Nitrous oxide decreases SSEP amplitude without an increase in latency

Volatiles anesthetics cause dose dependent decrease in amplitude and increase in latency

Hypoxia, hypotension, hypothermia, and hematocrit below 15% also affect both SSEPs and MEPs

All anesthetics affect spinal monitoring to varying degrees

Nitrous oxide decreases SSEP amplitude without an increase in latency

Volatiles anesthetics cause dose dependent decrease in amplitude and increase in latency

Hypoxia, hypotension, hypothermia, and hematocrit below 15% also affect both SSEPs and MEPs

Abnormal SSEPs and MEPsAbnormal SSEPs and MEPs

What if SSEPs and MEPs become abnormal during surgery? Ensure adequate oxygenation, ventilation,

and hemodynamics (adequate spinal cord perfusion)

Communication with surgeon as to possible surgical causes (instrumentation?)

What if SSEPs and MEPs become abnormal during surgery? Ensure adequate oxygenation, ventilation,

and hemodynamics (adequate spinal cord perfusion)

Communication with surgeon as to possible surgical causes (instrumentation?)

Risk factors associated with increasedperioperative and postoperative complications4


Neuromuscular disease Genetic syndromes Traumatic nerve/muscle

injuries Seizure disorders Decreased cognitive

ability Poor pulmonary status Restrictive lung disease

Neuromuscular disease Genetic syndromes Traumatic nerve/muscle

injuries Seizure disorders Decreased cognitive

ability Poor pulmonary status Restrictive lung disease

Frequent pneumonias Sleep apnea Malnutrition Cardiac disease Immune compromised Social status Ambulatory status Increasing complexity of

surgical procedure

Frequent pneumonias Sleep apnea Malnutrition Cardiac disease Immune compromised Social status Ambulatory status Increasing complexity of

surgical procedure



Pediatric patients with secondary scoliosis tend to have greater blood loss than those with idiopathic scoliosis

The exact reasons are unknown and are still under investigation but platelet dysfunction, poor vascular response, increased bleeding time, and fibrinolysis are some of the proposed reasons

Pediatric patients with secondary scoliosis tend to have greater blood loss than those with idiopathic scoliosis

The exact reasons are unknown and are still under investigation but platelet dysfunction, poor vascular response, increased bleeding time, and fibrinolysis are some of the proposed reasons

Transfusion managementTransfusion management

Blood loss is estimated to be in the range of 15-25 mL/kg in scoliosis surgery involving instrumentation2

For a 20 kg patient, blood loss can be estimated to be 300-500 mL

Patient’s estimated blood volume (EBV) assuming an average of 70 mL/kg is 1400 mL

Estimated allowable blood loss (ABL) is calculated as follows: ABL = EBV x [Hct (initial)- Hct (final lowest

acceptable)] / Hct (initial)

Blood loss is estimated to be in the range of 15-25 mL/kg in scoliosis surgery involving instrumentation2

For a 20 kg patient, blood loss can be estimated to be 300-500 mL

Patient’s estimated blood volume (EBV) assuming an average of 70 mL/kg is 1400 mL

Estimated allowable blood loss (ABL) is calculated as follows: ABL = EBV x [Hct (initial)- Hct (final lowest

acceptable)] / Hct (initial)

Given a starting Hct of 43 and assuming a lowest acceptable Hct of 20, the allowable blood loss would be: ABL = 1400 mL (43-20) / 43 = 750 mL

Given a starting Hct of 43 and assuming a lowest acceptable Hct of 20, the allowable blood loss would be: ABL = 1400 mL (43-20) / 43 = 750 mL

Given the anticipated large bleeding from a long complicated multilevel repair as well as patient risk factors, what evidence based interventions can minimize blood loss?

Given the anticipated large bleeding from a long complicated multilevel repair as well as patient risk factors, what evidence based interventions can minimize blood loss?

Minimize intraabdominal pressure to prevent further engorgement of the vertebral venous plexus and venous bleeding

Isovolemic hemodilution Intraoperative blood salvage Deliberate hypotension Antifibrinolytic drugs

Minimize intraabdominal pressure to prevent further engorgement of the vertebral venous plexus and venous bleeding

Isovolemic hemodilution Intraoperative blood salvage Deliberate hypotension Antifibrinolytic drugs

Antifibrinolytic therapy5,6Antifibrinolytic therapy5,6

Antifibrinolytic drugs have been shown to reduce blood loss and the amount of transfusion in children undergoing scoliosis repair

In a meta analysis of 6 randomized prospective controlled double blinded trials evaluating the use of antifibrinolytics versus control: the amount of blood loss in the antifibrinolytic group was

decreased by 426.53 mL (95% CI -602.51 to -250.56) the amount of blood transfused in the antifibrinolytic group

was decreased by 327.41 mL (95% CI -469.04 to -185.78) the risk of being transfused with homologous blood was 13%

lower in the antifibrinolytic group (95% CI 0.67 to 1.12) the risk of being transfused with allogeneic blood was 29%

lower in the antifibrinolytic group (95% CI -47% to -10%)

Antifibrinolytic drugs have been shown to reduce blood loss and the amount of transfusion in children undergoing scoliosis repair

In a meta analysis of 6 randomized prospective controlled double blinded trials evaluating the use of antifibrinolytics versus control: the amount of blood loss in the antifibrinolytic group was

decreased by 426.53 mL (95% CI -602.51 to -250.56) the amount of blood transfused in the antifibrinolytic group

was decreased by 327.41 mL (95% CI -469.04 to -185.78) the risk of being transfused with homologous blood was 13%

lower in the antifibrinolytic group (95% CI 0.67 to 1.12) the risk of being transfused with allogeneic blood was 29%

lower in the antifibrinolytic group (95% CI -47% to -10%)

There were no mortalities in either the treatment or control groups

Aprotinin, tranexamic acid, and aminocaproic acid seem to be similarly effective with excellent safety profile (no evidence of hypercoagulability or thrombotic complications)

High dose aminocaproic acid was used in the studies: 100 mg/kg bolus administered as an infusion over 15 to 20 minutes followed by a continuous infusion of 10 mg/kg throughout the remainder of the procedure

No comparisons of antifibrinolytics head to head No comparisons of different doses

There were no mortalities in either the treatment or control groups

Aprotinin, tranexamic acid, and aminocaproic acid seem to be similarly effective with excellent safety profile (no evidence of hypercoagulability or thrombotic complications)

High dose aminocaproic acid was used in the studies: 100 mg/kg bolus administered as an infusion over 15 to 20 minutes followed by a continuous infusion of 10 mg/kg throughout the remainder of the procedure

No comparisons of antifibrinolytics head to head No comparisons of different doses

Given the large surgical incision and musculoskeletal work over many levels, what are the best evidence based interventions for postoperative pain control?

Given the large surgical incision and musculoskeletal work over many levels, what are the best evidence based interventions for postoperative pain control?

Epidural anesthesia superior to IV PCA in pediatric scoliosis surgery7Epidural anesthesia superior to IV PCA in pediatric scoliosis surgery7

In a meta analysis of four randomized prospective controlled trials evaluating PCEA vs. IV narcotic PCA in adolescent patients undergoing scoliosis repair, epidural anesthesia was shown to provide superior postoperative analgesia at 24, 48, and 72 hours

Patients randomized to the epidural group underwent placement by the surgeon under direct visualization prior to closure

The treatment group received epidural analgesia in the form of a continuous infusion of local anesthetic with or without an opioid in addition to parenteral opioids

The control group received parenteral opioids only

In a meta analysis of four randomized prospective controlled trials evaluating PCEA vs. IV narcotic PCA in adolescent patients undergoing scoliosis repair, epidural anesthesia was shown to provide superior postoperative analgesia at 24, 48, and 72 hours

Patients randomized to the epidural group underwent placement by the surgeon under direct visualization prior to closure

The treatment group received epidural analgesia in the form of a continuous infusion of local anesthetic with or without an opioid in addition to parenteral opioids

The control group received parenteral opioids only

Blinding was not possible because placement of a sham epidural is associated with morbidity

visual analog scale pain scores in the PCEA group were found to be lower at 24, 48, and 72 hrs VAS pain scores were 15 points lower at 24 hours (p=0.03) VAS pain scores were 10.1 points lower at 48 hrs (p=0.03) VAS pain scores were 11.5 points lower at 72 hrs (p=0.02)

Patient satisfaction was higher by 1.7 on a 0-10 scale in the two studies that assessed it (p<0.0001)

Some but not all studies showed decreased nausea, pruritis, and number of rescue analgesics in epi grp

Some but not studies demonstrated shorter time to return of bowel function in the epidural group

Blinding was not possible because placement of a sham epidural is associated with morbidity

visual analog scale pain scores in the PCEA group were found to be lower at 24, 48, and 72 hrs VAS pain scores were 15 points lower at 24 hours (p=0.03) VAS pain scores were 10.1 points lower at 48 hrs (p=0.03) VAS pain scores were 11.5 points lower at 72 hrs (p=0.02)

Patient satisfaction was higher by 1.7 on a 0-10 scale in the two studies that assessed it (p<0.0001)

Some but not all studies showed decreased nausea, pruritis, and number of rescue analgesics in epi grp

Some but not studies demonstrated shorter time to return of bowel function in the epidural group

Management of spinal shock8,9Management of spinal shock8,9

Ensure adequate tissue perfusion with volume resuscitation

Favorable outcomes reported in uncontrolled studies using fluid resuscitation and vasopressive medications to maintain a minimum mean ABP of 85 mmHg during the 1st week following spinal cord injury in adults

Assess for bradycardia and arrhythmias associated with neurogenic shock and treat appropriately

To counter the loss of sympathetic tone and provide chronotropic support, vasopressors with both alpha and beta adrenergic actions are recommended unless contraindicated

Ensure adequate tissue perfusion with volume resuscitation

Favorable outcomes reported in uncontrolled studies using fluid resuscitation and vasopressive medications to maintain a minimum mean ABP of 85 mmHg during the 1st week following spinal cord injury in adults

Assess for bradycardia and arrhythmias associated with neurogenic shock and treat appropriately

To counter the loss of sympathetic tone and provide chronotropic support, vasopressors with both alpha and beta adrenergic actions are recommended unless contraindicated

ReferencesReferences

1. Cote. A Practice of Anesthesia for Infants and Children, 3rd ed. 2001

2. Zayas, V, Yao, F, et al. Scoliosis. Anesthesiology: Problem Oriented Patient Management, 6th ed. 2008

3. Miller, R. Miller’s Anesthesia, 6th ed. 20054. Erickson M, et al. Pathways that distinguish simple

from complex scoliosis repair and their outcomes. Current Opinion in Pediatrics 2011, (23):339-345

5. Tzortzopoulou A, et al. Antifibrinolytic agents for reducing blood loss in scoliosis surgery in children. Cochrane Database of Systematic Reviews 2008, Issue 3

1. Cote. A Practice of Anesthesia for Infants and Children, 3rd ed. 2001

2. Zayas, V, Yao, F, et al. Scoliosis. Anesthesiology: Problem Oriented Patient Management, 6th ed. 2008

3. Miller, R. Miller’s Anesthesia, 6th ed. 20054. Erickson M, et al. Pathways that distinguish simple

from complex scoliosis repair and their outcomes. Current Opinion in Pediatrics 2011, (23):339-345

5. Tzortzopoulou A, et al. Antifibrinolytic agents for reducing blood loss in scoliosis surgery in children. Cochrane Database of Systematic Reviews 2008, Issue 3

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