pathophysiology of nephrolithiasis, struvites stone (staghorn calculi)
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Transcript of pathophysiology of nephrolithiasis, struvites stone (staghorn calculi)
NEPHROLITHIASIS : PATHOPHYSIOLOGY
Non modifiable factors:
-Age -Sex
Modifiable factors:
-Diet (unusually high in soy & fish sauce, bagoong, softdrinks, legumes, protein & salt)-Certain meds (Analgesics)-Low fluid intake-Urinary stasis-Smoking & alcoholic drinking-Gouty arthritis
Randall’s plaque
Nephrocalcinosis on proximal tubule
Uric acid ), ammonia phosphate , and calcium oxalate stone material deposition on proximal
renal tubule
Episodes of pain in side radiating in the back
Nidation of crystals or foreign bodies from the
supersaturated urine
PyuriaIncrease production of WBC
Urinary Tract Infection caused by urea splitting organism
Super saturation of urine by stone forming
constituents (↓OFI)
Hyperkalemia
Stones obstructing the kidneys
Stones formation <5mm in kidneys
Stone matrix & progression
MULTIPLE URINARY CALCULUS
Proteinuria(+1)
Staghorn calculus
Dysuria
Hematuria
Accumulation of stones & increasing in size
Progression of stones in Loop of Henle
Blood vessels wall surface attraction and erosion
Renal colic radiating to the back & leg
Bilateral swelling of the knees and adjacent parts
(Edema)
Nidation of crystals or foreign bodies from the
supersaturated urine
Increase production of WBC
Pyuria