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Oral Hist1
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Transcript of Oral Hist1
DEVELOPMENT OF TEETH
Introduction 6th week of intra uterine life
Stomatodeum (primitive oral cavity) consists of epithelium and connective tissue
Complex process involving epithelium & mesenchymal interactions.
Connective tissue contains cells derived from neural crest hence called as ectomesenchyme.
Horseshoe shaped band like proliferation of epithelium forms the DENTAL LAMINA
Dental lamina further forms the enamel organ of the developing teeth
Dental lamina further proliferates at 10 points corresponding to 10 decidous teeth.
Lingual extension – permanent succecsors Buccal extension – vestibular lamina Distal extension – permanent molars
Dental lamina - Enamel organ Ectomesenchymal condensation – Dental papillae
Dental follicle / sac
Enamel organ forms ENAMEL Dental papillae forms DENTIN & PULP Dental follice forms CEMENTUM, PERIODONTAL LIGAMENT
& ALVEOLAR BONE
Oral epithelium
Dental lamina
Enamel organ
Future dental papilla
Stages of tooth developmentTooth formation is a continuous process based on the shape of the
enamel organ it is divided into stages Bud Stage Cap Stage Early bell stage Advanced bell stage
Based on the physiologic phase the development of tooth can be also divided in to physiologic stages
Initiation Proliferation Histodifferentiation Morphodifferentiation Apposition
BUD stage
The enamel organ resembles a bud It consists of peripheral low columnar cells & central polyhedral cells Ectomesenchymal condensation can be seen Difference between dental papillae and dental follicle is not evident
CAP Stage
Unequal proliferation transforms the bud into a cap like structure Enamel organ shows 3 distinct layers
Outer enamel epithelium – convex part– cuboidal cells Inner enamel epithelium – concave part – columnar cells Stellate reticulum - polygonal (star shaped network)
polygonal cells produce albumin increase in intercellular fluid cushion like effect protects enamel forming cells.
CAP Stage Enamel knot, cord, septum, navel – transient structures seen in the
center of enamel organ. Enamel knot – knob like accumulation Enamel cord – vertical extn of knot Enamel septum – knot extending from inner enamel epith to outer
enamel epith dividing the enamel organ Enamel navel – depression on the outer surface of enamel organ
Earlier thought to be only reservoir for dividing cells but now known to act as signaling center & plays a role in determining the shape of the tooth.
‘Enamel Niche’
Dental papilla becomes more cellular and occupies the concavity of the enamel organ.
Dental follice is more fibrous and surrounds both the enamel organ & papilla
Early Bell Stage
Early Bell Stage Enamel organ assumes bell shape 4 distinct layers – 3 of cap stage and stratum intermedium. Inner enamel epith converts to ameloblasts “Reciprocal induction” begins Cervical loop is appreciated Dental lamina disintegrates – cell rests of serres (epithelial
pearls) Dental papilla & dental follicle become more organized. “Membrana Preformative” – Future dentinoenamel junction
Advanced Bell Stage
Advanced Bell Stage Ameloblasts and odontoblasts can be clearly demarcated.
Enamel and Dentin formation begins (reciprocal induction)
Stellate reticulum collapses to facilitate nutrition.
After hard tissue formation dental papilla is known as dental pulp.
Hertwigs epithelial root sheath proliferates from cervical loop leading to root formation.
Fibres of dental sac become more organized to resemble periodontal ligament.
Reciprocal Induction
Root FormationHertwigs epithelial root sheath (HERS) consists of inner & outer enamel epithelium.
Hard tissue formation reaches the future CEJ [cervical loop]
HERS proliferates downwards
inner cells induce dental papillae cells to differentiate into odontoblasts
formation of radicular dentin
rupture of HERS [cell rest of mallasez]
Dental follicle comes in contact with dentin
differentiation of cementoblasts & cementum formation.
Formation of multirooted teeth
Cell rests of mallasez Enamel pearls & Epithelial pearls
Physiologic stages of tooth development Initiation: induction by epithelial – mesenchymal interaction
Proliferation: increases in size and grows from bud to cap & bell stages
Histodifferentiation: basic cells transform into various layers and assume their functions, i.e. become specialized.
Morphodifferentiation: basic size and form of the tooth are determined.
Apposition: deposition of hard tissues.
Applied aspects
Enamel hypoplasia Mottelled teeth Turners hypoplasia Anodontia Supernumerary teeth Taurodontism Dens invaginatus Odontogenic cysts & tumors Dens evaginatus Enameloma
OVERVIEW