Neuroplasticity Development of the Nervous System.
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Transcript of Neuroplasticity Development of the Nervous System.
Neuroplasticity
Development of the Nervous System
Between 4 weeks and 9 months the brain undergoes rapid development
Development of the Brain
Stages of neuroanatomical development
a. Zygote stage: Begins upon fertilization of the ovum
i. 2 sets of 22 chromosomes, and one set of sex chromosomes. Total of 23 pairs of
chromosomes (XX= female, XY= male)
ii. Stages of fertilization
(1) 12-30 hours – first cell division
(2) 3 days – division continues until a solid ball is formed
(3) 5 days – continue to divide, but cells move toward outer edge of blastocyst
(4) 6 days – cells begin to move inward
(5) 8 days – beginning of embryonic disc
& zygote becomes attached to the uterus
(6) 14 days – zygote is completely
attached to the uterus and embryonic disc is
fully formed
From Conception to 8 days
b. Embryonic stage (14 days – 8 weeks): Begins at the full formation of embryonic disc i. Mesoderm: contains chemical signals for various areas of nervous system; directs formation
ii. Endoderm: forms everything else iii. Ectoderm: forms nervous system (brain),
fingernails, hair, and skin. Changes:1. Thickens in the middle (neural plate)2. Groove starts to form (neural groove)3. Groove closes to form tube (neural tube) a. At the top of canal is neural crest,
forms PNS
Simplified View of Neural Plate Formation
Formation of the Neural Plate with the thickening of Ectoderm
Formation of the Brain, Spinal Cord and PNS(Neuroectoderm)
iv. Neuroectoderm forms when foundation for the three main structures has been developed:
1. 3 swellings
a. Hindbrain
b. Midbrain
c. Forebrain
2. Closed Neural Tube becomes spinal cord
central canal and ventricles of the brain
v. Spina bifida – Neural Tube Defect (NTD) - spinal cord doesn’t close, often linked to
mental retardation
**NTDs can be discovered in utero **
vi. Amount of mesoderm in relation to ectoderm determines the nervous system region 1. Amount of signal/tissue coming from mesoderm determines spinal cord/brain Determination: A process that ensures that a population of cells will give rise to specific systems in developing organism Regional specificity: Once signal is in place we lose the plasticity of the blastocysts. Irreversible signal set by a genetic code after formation of neuroectoderm.
Ectoderm to Neuroectoderm: 20 days to 30 days
Fetal Period: Two Months to Birth (38 weeks)
Fetal Period
• Foundation for the entire CNS is set
• 6 stages of CNS development complete the prenatal process
Neuronal Proliferation
(embryonic stage through fetal stage)
Midbrain Ventricular Intermediate Marginal
Hindbrain Zone Zone Zone
Forebrain Ventricul. SubV Intermed. Cortical Marginal
Zone Zone Zone Plate Zone
Neuronal Proliferation
Six Stages of Nervous System Development
1. Mitosis (cell division) or Neurogenesis in the ventricular zone, One cell division can lead to a daughter cell, will divide again forming an immature neuron
2. Migration: cells move from VZ to their destination; this migration is aided by glial cells, abnormal migration found in a number of disorders. Filopodia assist in finding location after leaving radial glial cells.
Abnormalities in migration are presentin people with learning disabilities, schizophrenia and autism (more on this
in a little while)
Cell Migration During Brain Development: Hindbrain & Midbrain
Forebrain Development
Growth Cones & Filopodia
Filopodia
3. Differentiation: The Process which gives rise to specific neurons and glial cells
4. Synaptogenesis: Neuronal maturation 1. Elongation of axons (w/growth cones) 2. Establish terminals 3. Elongation of dendrites 4. Expression of NT
Neurotrophic factors – stimulate cell growth, i.e. nerve growth, factor helps neuron to mature.
5. Normal cell death (more on this later)
- Apotosis – active cell death during development
- Necrosis – passive cell death due to injury
6. Synaptic rearrangement: dependent on apotosis and experience!!!!
Theories as to why/how this happens 1. Chemoaffinity hypothesis – Post synaptic cell is releasing a chemical 2. Blueprint hypothesis – Cell adhesion
molecule present, guides neuron to destination
3. Topographic gradient hypothesis – Axons are growing based on position of
cell body, spatial growth **All three appear correct, happens
differently in different areas**
Postnatal Development of the Central Nervous System
Post-natal brain development1. At birth the brain weighs 25% of the full adult brain2. By the age of 6 it increases to 95% i. Increase is due to myelination
a. At birth the brain is myelinated through the thalamusb. Myelination is in part based on experience (the premature baby will have substantially more myelin than
that of the full term baby)
ii. Proliferation of glial cells
iii. Last wave of neurogenesis
iv. Maturation of neurons
v. Increase in synaptic connectivity
Cellular Development of the Postnatal Brain
Cells of the Cerebral Cortex
Cell of the
Cerebellum
Brain Development Occurs in Waves through Age 21
• Temporal
• Parietal
• Limbic
• Frontal
Brain Increases Connections Between Birth and 21 years old.
Age
Changes from Birth – 21:Temporal Lobes or Language
Areas
Age
Changes from Birth – 21:Parietal-Temporal Areas for Higher
Cognitive Functioning
Age
Changes from Birth – 21:Limbic System for
Emotions/Attachment
Age
Changes from Birth – 21: Frontal Lobes for Behavioral
Control
Age
VII. How experience affects development
1. Neural activity regulates gene expression that directs synthesis of cell adhesion molecules
2. Neuronal activity regulates the release of neurotrophins (NGF) that are released from the dendrites; after synaptic connectivity
3. Stimulates foundation NT and this promotes subsequent development
Experience can Modify Brain Cell Connections
Active Cell Death – 40% occurs during the first 2 years of life, and it occurs on a different scale in adolescence
(hormone related, final sculpting 1. Essential because many cells are unconnected and useless2. Dysfunction in apoptosis is seen in post-
mortem brains of children with autism (particularly problems in cerebellum, midbrain, & hippocampus);
insufficient hooking up of neurons
Removal of Brain Cells during Early Childhood
Brain Cells can Continue to Develop in Abnormal Ways
Early Childhood
Adulthood
Example of normal and abnormal cell connections andarrangements that can occurin different brain systems.