'Neuroinflammation, excitotoxic and neurodevelopmental disease induce specific forms of Neuronal plasticity: Towards novel platforms for pharmacological screening and biomarker discovery?’• 3U-COEN Centre of Excellence in the Neurosciences • Department of Physiology and Medical Physics, Royal College of Surgeons in

Ireland

Dr Hans-Georg KoenigLecturer in Physiologyhgkoenig@rcsi.ie

We do:Disease programmes

• ALS • Alzheimer’s disease• Neuroinflammation• Stroke

Thematic areas:• Excitotoxicity• Axon-initial segment & axonal

plasticity• Neural Stem cells &

Neurospheres• NF-kB and Growth-factor

signaling

We have: Live cell imaging LSM and High-content imaging facilities and broad Neuro culture know how!

We seek:

• Natural compounds/libraries towards:– AIS / Axon-protective

strategies – Neuroprotective strategies– Affect axon-specification– Anti-inflammatory

– Preservation of Mitochondrial respiration

– ‘Neuroenhancer’ potential

• Peptide biomarker screening• Nanoparticles transduction of

neurons / stem cells• Blood-brain barrier model• iNeurons & iPSCs

hgkoenig@rcsi.ie+353-1-402-2122

Please join us this Thursday, 26/02, 14:30 PM, Royal College of Surgeons, RBI-3U - Neuroscience Day

Topics:• Excitotoxic & metabolic nervous system disorders• Alzheimer• Schizophrenia• Psychosis• Bipolar disease• Epilepsy• Neural Stem Cells

http://www.rcsi.ie/csndhttp://www.neuro-centre.ie/research/

Prof. Jochen Prehn

prehn@rcsi.ie

Dr Hans-Georg Koenig