Nestlé Science & Research

Nutrition &Life SciencesNutrition &

Life Sciences ProcessingProcessing

Quality&

Safety Sciences

Quality&

Safety Sciences

Consumer Perception & Preferences

Consumer Perception & Preferences

Consumer Perception &Preferences

Nutrition & Life Sciences Processing

Quality & SafetySciences

Dr Bruce German

Disclaimer

This presentation contains forward looking statements which reflect Management’s current views and estimates. The forward looking statements involve certain risks and uncertainties that could cause actual results to differ materially from those contained in the forward looking statements. Potential risks and uncertainties include such factors as general economic conditions, foreign exchange fluctuations, competitive product and pricing pressures and regulatory developments.

Goals of 1st INS Are People all the same in response to diet, health and disease risk

Are there methods that can assess health status, predict the trajectory of health and act to prevent disease

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Consensus from 1st INS

Humans differ Genetically AND by Lifestyle choices

The Tools to measure Metabolism in individuals exist but are not yet brought to practice

But do we need to assess Health?

Now:

More and More Humans are suffering from Health problems due to Metabolic imbalances

Goals of 2nd INS

Assemble the world’s scientific leaders in the regulation of Energy Metabolism

Discuss the solutions that could solve the problems of Obesity, Diabetes and Metabolic Disorders

Consensus from 2nd INS

Metabolic Diseases are being driven by a combination of inappropriate environmental factors (diet-lifestyle) on a background of genetic susceptibility

The consequences of metabolic disorders will be devastating to many aspects of public health

The regulation of metabolism and the basis dietary choices lie in the brain

Next

What is the role of Diet in Brain Functions?

Goal of 3rd INS Assemble the world’s scientific leaders in the regulation of Brain Mechanisms and Functions

How does the brain react to food and can food alter the functions and slow the deterioration of these functions during aging

• The human brain is an astonishing engine that demands massive fueling

• Our senses of taste, smell, touch, vision and hearing when activated by food ‘light up’ most of our brain

Consensus from 3rd INS

• We are beginning to understand the important role of food in fueling the brain and the important role of the brain in choosing food

• The potential of good diets to improve brain functions are greater than we previously thought

• The potential of bad diets to deteriorate brain functions are worse than we previously thought

Next

• How does diet effect the cellular mechanisms and processes of Cancer?

Consensus from 3rd INS

Goals of the 4th INS

• What are the causes of the developmentof cancer

• What solutions are emerging

• How can nutrition help

Concensus of the 4th INS

The Cell cycle is ‘checked’ at multiple points

• Damage to cellular check points are critical to cancer development

• Damage can be from toxins, pathogens, radiation even inflammation

• Therapies are increasingly targeted to specific damage sites

• Nutritional demands of the cancer patient are unique

DNA Damage

Goals of the 5th INS

• How are our cellsfueled

• What fuels ouroverall development

• What determineshuman performance and recovery

Session 1 The Powerhouse

• The membrane is a nano battery

• All cells fuel themselvesby using the charge of their nanobatteries to make ATP

• The process of makingATP from a nanobatteryuses a molecular stepper motor

Session 1 The Muscle

• The muscle cell requiresstimulation: Use it or Lose it

• Muscle Development and Degradation are active processes

Session 2 The Controls• Muscle is controlled by Nuclear

Receptors• Exercise turns these Nuclear

Receptors on• Drugs targeting these receptors mimic

exercise in animal models

Session 2 The Problems• The Environment in

which children growup is changing

• Exercise and physical playopportunities are shrinking

• The consequencescould be prolongedin overall health of the population

Session 2 Bones• Bones store Calcium• Bone is stimulated by exercise• Nutritional Status and Exercise are

critical to build and retain bonesthrough life

Session 3 Performance• Peak performance is limited by our

heart’s ability to deliver oxygen –stroke volume

• All people and all ages benefit fromexercise training with important physiological benefits

Session 3 Limits• Human achievements continue to

improve but by smaller increments• Thermal regulation is a key to

endurance performance

Session 3 in Practice• Optimal diet and exercise depends

on the specific event• The margin of victory in elite events

is very very small• Every little bit helps - sometimes

Session 4 Sarcopenia• The balance of muscle building and

destruction changes with age• Inactivity is devastating to the

balance of muscle • Timing of eating is important as well

Session 4 Nutrition• Exercise and Nutrition interact in the

protection of muscle during aging• Muscle is conspicuously protective

of metabolic health physiologicalhealth and cognitive health

Consensus from 5th INS

Exercise/Physical Activity is highly beneficial to human health at all ages

Inactivity is devastating to human health at all ages

Nutrition can enhance the benefits of exercise

But:

Nutrition’s ability to prevent the damage of inactivity is limited

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Nestlé's global R&D network

External partners: pushing frontiers of science and its

application

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