NeSSI™ - Gen IIIFinding the Longitude – the microAnalytical Vision

Rob DuboisCPAC/NeSSI™ Workshop – PM Session

Seattle, Washington, USAMay 6, 2004

“the best way to predict the future is to create it”

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Who is John Harrison?

Like squaring the circle or inventing a perpetual motion machine, the phrase 'finding the longitude' became a sort of catchphrasefor the pursuits of fools and lunatics. Many people believed that theproblem simply could not be solved.

1693-1776

Courtesy of ©NMM London.

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Today’s Analytical SystemThe Technology of Last Resort!

• More of an “art” than a “science”

• Expensive– up to 60% of costs

after purchase• Require large sample &

utility usage• Skilled maintenance staff

required

Courtesy of Dow Chemical, Freeport, TX

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Smaller SizeHigher System Reliability

Time

Ad HocInstallations

EngineeredAnalyzer House

By-Line/In-Line

Technology Explosion!

• Fast networks/computers

• Robust/miniature electronics

• Lab-on-a-chip; optics; wireless

• Fiber optic sensors

What does the Market Need?

• Reliable, rugged, low cost & fast

What are the Critical Issues?

• Development Cost

• Technology hurdles

• Market acceptance

1938 2000

MicroAnalytical & Process Analytical

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The Ideal microAnalytical Device for Process Analytical (1/4)

• Has global electrical (hazardous) Certifications• Embedded multi-drop digital protocol• Plug & Play (self-identifies)• Robust (> 99.9% uptime)

– Embedded smarts/Self-diagnostics– minimum or no moving parts – modular replacement

• Low cost (c. <$5K)– <$1K “disposable”

• Embedded documentation

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The Ideal microAnalytical Device for Process Analytical (2/4)

• Multi-Component Analysis– multi-component: GC, MS, SPECTROSCOPY– unimolecular sensors

• Suitable for operating as a Functional Clusters– pH, DO2, Conductivity: “water package”– NOx, O2, CO: “CEMS package”

• Gas and/or Liquid Service• Wide Sensitivity: “Configurable” rangeability

– PPB, PPM, PERCENT

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The Ideal microAnalytical Device (3/4)

• Fast (continuous) Response (< 10 seconds)• Physically small in size • Low Power (for intrinsic safe operation)• Impeccable selectivity

– under both normal & upset conditions• 316L SS (typ.) or process compatible• Self Correcting (drift compensation within limits)

– Ambient temp/pressure changes– Sample pressure/flow/temp changes

• Self-checking/calibrating• Low/No Utility or Reagent Usage

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The Ideal microAnalytical Device (4/4)

(conditioned sample)• Typ. Pressure:

– (typical) vacuum to 150 psig– (higher) vacuum to 500 psig

• Typ. Temperature: -20 to 80 C.• Flow (gas)

– 3 to 200 cc/min and 3 to 2,000 cc/min• Flow (liquid)

– 1 to 300 cc/min and 1 to 1,500 cc/min

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Analytical Sensors (Gen III)

SAM

Fiber Optic

AT

One sensorper component“lab on a chip”

One Sensor measuringMultiple Analytes

VTP

A

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NeSSI™: Enabler for MicroAnalytical(the “rail” concept)

Standard Mechanical Interface “Rail”

Standard Electrical (Digital) Interface “Rail”

Anyone’s Sensor Anyone’s Actuator

SAM*

Standard “hockey-puckPC”

P

V

*Sensor/Actuator Manager

Standard“connectivit

y”

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NeSSI™ an Enabling Technology for microAnalytical

• provides clear “standards”• lowers infrastructure development costs and

associated entry risk (faster to market)• developer can concentrate on providing a

premiere microAnalytical sensor – rather than infrastructure

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Water “Cluster” Measurement

Sensor Capsule Courtesy of Predictive Controls

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Substrate Substrate

On/Off and On/Off and Modulating valvesModulating valves

Flow Sensor w/ Flow Sensor w/ Temp, Pressure Temp, Pressure w/ Tempw/ Temp

Substrate

Moisture in Moisture in Dry GasesDry Gases

PHASED *PHASED * Micro GC Micro GC

Other Analytical:Other Analytical:Ion, Nox. OIon, Nox. O2, 2, pHpHConductivity, Conductivity, NOx, Turbidity,NOx, Turbidity,Density, OpacityDensity, OpacityRefractive Index,Refractive Index,OthersOthers

ChemometricChemometricSensors for Sensors for Complex AnalyticalComplex AnalyticalMeasurements.Measurements.

ModValve

D/A

Network

Press/Temp

A/D

Network

*PHASED: Courtesy of Honeywell

microGC

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Conclusion

• NeSSI™ provides an enabling platform for microAnalytical

• microAnalytical will provide the greatest value and impact to End Users

• Just like John Harrison, finding the longitude in microAnalytical, is fast becoming a reality. Solution to longitude

problem – a miniature, accurate, seaworthy timepiece.

Courtesy of ©NMM London