Multiple Myeloma Plasmacytoma Heavy Chain Disease Waldenstroms Macrogloblinemia Monoclonal Gammapathy Of Unsignificance Primary Amyloidosis

50-60 yrs. Men 1% death Pathogenesis: IL 6,-proliferation and survival of plasma cells MIP1alpha and RANKL -osteolysis Molecular pathology Deletions of 13q,translocations on 14q32,

Derangements of cyclin D1 and D3.

Plasmacytoma

Heavy Chain Disesase

Primary Immunocyte Associated Amyloidosis