Multifactorial d1
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Transcript of Multifactorial d1
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HEALTH.2012.2.1.2-2: SYSTEMS MEDICINE: APPLYING SYSTEMS BIOLOGY APPROACHES FOR
UNDERSTANDING MULTIFACTORIAL HUMAN DISEASES AND THEIR CO-MORBIDITIES
Partners:- Donetsk national medical university
Departments of Histology, Cytology and Embryology, Propaedeutics of Internal Medicine, Department of Dermatology, Medical Biophysics, Medical Equipment and Clinical Informatics
-Laboratory of fundamental research (Institute of Urgent and Recovery Surgery)
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MULTIFACTORIAL HUMAN DISEASES AND THEIR CO-MORBIDITIES
Embryonic development
Genotype
Diet, nutrients Environmental factors
Life Style
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INTRINSIC AND EXTRINSIC FACTORS INTERACTION
Various clinical manifestation Co-morbidities???
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DiabetesDiabetes
AtherosclerosisAtherosclerosis
ObesityObesity
Coronary diseases
Coronary diseases
Digestive system pathology
Digestive system pathology
Endocrinological disturbance
Endocrinological disturbance
Autonomic system dysregulacation
Autonomic system dysregulacation
Metabolical disturbance Metabolical disturbance
ImmunopatholgyImmunopatholgy
Co-morbidities of multifactorial diseases
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Proposition
Gene polymorphism
Cells response and resistance to different stimuli
Investigation of Cross-interactions in regulatory axis and metabolic ways of affected organs and their dependence on
individual reactivity of organism
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PATIENTS WITH:
PROPOSED DESIGN OF INVESTIGATION
ClinicalInstrumentalLaboratoryBiochemicalImmunoenzymological
METHODS:
ATHEROSCLEROSIS
ANGINA. INFARCTION OF MYOCARDIUM
ISCHEMIC STROKE
PEPTIC ULCERS OF STOMACH AND DUODENUM
MorphologicalImmunocytochemicalMoleculo-geneticBiostatistics, Neurocybernetics
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PROPOSED DESIGN OF INVESTIGATION
Regulatory axis in affected organ, system
Interlinks / co-morbities
Organ specific regulators
Regenerative potential
Metabolic peculiarities
State of innate and adaptive immunity
Network analysis
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PLATELETS
Participate in:
- atherothrombosis- inflammation- vessels remodeling- reparation
PROPOSED MODEL FOR ANALYSIS
In vitro analysis of: AggregationSensitivity to systemic and organospecific regulators
PLATELETS AS SENSORS OF CARDIOVACULAR SYSTEM AND MIRROW OF REACTIVITY
Intracellular signaling systemsGranules and hyaloplasm content Enzymes activity
PLATELETS
Are targets for:
- Hormones- Neurotransmitters- cytokines- chemokines
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1. Establish the role and key determinants of reactivity of organism in organospecific pattern of multifactorial diseases.
2. Detect the key regulatory factors in development, progression and risk of co-morbid pathology associated with AS.
3. Develop the system of prognostic criteria of organospecific manifestation of atherosclerosis.
EXPEXTED RESULTS
DEVELOPMENT OF INDIVIDUALIZED STRATEGY OF THERAPY
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