Modeling allosteric regulation of de novo pyrimidine biosynthesis in Escherichia coli.

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Modeling allosteric regulation of de novo pyrimidine biosynthesis in Escherichia coli. M. Rodrıgueza et al. JTB 234 (2005) 299–310 N-(phosphonacetyl)- L-aspartate (PALA) 5FU

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Modeling allosteric regulation of de novo pyrimidine biosynthesis in Escherichia coli. M. Rodrıgueza et al. JTB 234 (2005) 299–310. N-( phosphonacetyl)- L-aspartate (PALA). 5FU. Not overlaid to avoid calling attention to a poor fit?. - PowerPoint PPT Presentation

Transcript of Modeling allosteric regulation of de novo pyrimidine biosynthesis in Escherichia coli.

Page 1: Modeling allosteric regulation of de novo pyrimidine biosynthesis in Escherichia coli.

Modeling allosteric regulation of de novo pyrimidine biosynthesis in Escherichia coli. M. Rodrıgueza et al. JTB 234 (2005) 299–310

N-(phosphonacetyl)-L-aspartate (PALA)

5FU

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Not overlaid to avoid calling attention to a poor fit?

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Subcellular Localizationofthe Novo Pyrimidine Nucleotide ... · Pyrimidine biosynthesis in mammalian cells involves two multifunctional soluble proteins: the CPSase/AC-Tase/DHOase

Subcellular Localizationofthe Novo Pyrimidine Nucleotide ... · Pyrimidine biosynthesis in mammalian cells involves two multifunctional soluble proteins: the CPSase/AC-Tase/DHOase

Cell Death and Survival - Molecular Cancer ResearchFluR cells. We propose targeting de novo pyrimidine biosynthesis and mitochondrial respiration as potential strategies to overcome

Cell Death and Survival - Molecular Cancer ResearchFluR cells. We propose targeting de novo pyrimidine biosynthesis and mitochondrial respiration as potential strategies to overcome

Disclaimer · 2019. 11. 14. · DHF THF MTHFR TS ATIC Pyrimidine synthesis Purine biosynthesis Adenosine accumulation MTX DHFR FPGS GGH Efflux transporter Figure 1. Effect of methotrexate

Disclaimer · 2019. 11. 14. · DHF THF MTHFR TS ATIC Pyrimidine synthesis Purine biosynthesis Adenosine accumulation MTX DHFR FPGS GGH Efflux transporter Figure 1. Effect of methotrexate

EpidermalGrowthFactorReceptor(EGFR)Signaling ... · Results: EGF receptor signaling has an important role for glycolysis, pentose phosphate pathway, and pyrimidine biosynthesis in

EpidermalGrowthFactorReceptor(EGFR)Signaling ... · Results: EGF receptor signaling has an important role for glycolysis, pentose phosphate pathway, and pyrimidine biosynthesis in

27.23 Pyrimidines and Purines - Columbia University · Pyrimidines and Purines Pyrimidine and purine are the names of the ... DNA and Protein Biosynthesis According to Crick, the

27.23 Pyrimidines and Purines - Columbia University · Pyrimidines and Purines Pyrimidine and purine are the names of the ... DNA and Protein Biosynthesis According to Crick, the

Novel and potent inhibitors targeting DHODH, a rate-limiting … · Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum

Novel and potent inhibitors targeting DHODH, a rate-limiting … · Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum

Title Studies on the fermentative production of pyrimidine ... · of carbohydrates and biosynthesis of polysaccharides. Over sÅ}xty of the siullar class of compounds containing different

Title Studies on the fermentative production of pyrimidine ... · of carbohydrates and biosynthesis of polysaccharides. Over sÅ}xty of the siullar class of compounds containing different

BIOSYNTHESIS OF 5-PHOSPHORIBOSYL-1 ...real-j.mtak.hu/8828/9/ECB2016.vol.5.no.8.p.314-363.pdfsalvage biosynthesis of purine, pyrimidine and pyridine nucleotides as well as tryptophan

BIOSYNTHESIS OF 5-PHOSPHORIBOSYL-1 ...real-j.mtak.hu/8828/9/ECB2016.vol.5.no.8.p.314-363.pdfsalvage biosynthesis of purine, pyrimidine and pyridine nucleotides as well as tryptophan

Molecular Modeling on Pyrimidine-Urea Inhibitors of TNF ...users.uoa.gr/~tmavrom/2012/Molecular Modeling on Pyrimidine-Urea... · Molecular Modeling on Pyrimidine-Urea Inhibitors

Molecular Modeling on Pyrimidine-Urea Inhibitors of TNF ...users.uoa.gr/~tmavrom/2012/Molecular Modeling on Pyrimidine-Urea... · Molecular Modeling on Pyrimidine-Urea Inhibitors

Allosteric Enzymes Allosteric enzymes have one or more allosteric sites Allosteric sites are binding sites distinct from an enzyme’s active site or substrate-binding.

Allosteric Enzymes Allosteric enzymes have one or more allosteric sites Allosteric sites are binding sites distinct from an enzyme’s active site or substrate-binding.

The Synthesis and Degradation of Nucleotidesacademic.mu.edu/bisc/siebenlistk/3213nucleotide...The allosteric enzymes and molecules that control their activity. III. Pyrimidine biosynthesis

The Synthesis and Degradation of Nucleotidesacademic.mu.edu/bisc/siebenlistk/3213nucleotide...The allosteric enzymes and molecules that control their activity. III. Pyrimidine biosynthesis

Pyrimidine metabolism

Pyrimidine metabolism

Allosteric regulation of menaquinone (vitamin K2 ... · allosteric site the active site. to This is the first evidence of feedback regulation of the menaquinone biosynthesis pathway

Allosteric regulation of menaquinone (vitamin K2 ... · allosteric site the active site. to This is the first evidence of feedback regulation of the menaquinone biosynthesis pathway

Isolation and Characterization of Pyrimidine-Psoralen ... · Pyrimidine-Psoralen-Pyrimidine Photodiadducts from DNA David Kanne, Kenneth Straub, ... as an effective treatment for

Isolation and Characterization of Pyrimidine-Psoralen ... · Pyrimidine-Psoralen-Pyrimidine Photodiadducts from DNA David Kanne, Kenneth Straub, ... as an effective treatment for

PURINE & PYRIMIDINE METABOLISM

PURINE & PYRIMIDINE METABOLISM

Pyrimidine – Lecturenjms.rutgers.edu/gsbs/olc/core1/prot/2008/Birge-PYRIMIDINE CORE... · Pyrimidine-Lecture Overview Conversion of ribose bases to deoxyribose bases Biosynthesis

Pyrimidine – Lecturenjms.rutgers.edu/gsbs/olc/core1/prot/2008/Birge-PYRIMIDINE CORE... · Pyrimidine-Lecture Overview Conversion of ribose bases to deoxyribose bases Biosynthesis

Pyrimidine – Lecturenjms.rutgers.edu/sgs/olc/core1/prot/2008/Birge-PYRIMIDINE CORE COURSE-1.pdf · Pyrimidine biosynthesis begins with the assembly of the ring, then linked To ribose

Pyrimidine – Lecturenjms.rutgers.edu/sgs/olc/core1/prot/2008/Birge-PYRIMIDINE CORE COURSE-1.pdf · Pyrimidine biosynthesis begins with the assembly of the ring, then linked To ribose

Mevalonate Pathway Provides Ubiquinone to Maintain ... · pyrimidine nucleotide biosynthesis and induced oxidative stress and apoptosis in p53-deficient cancer cells in spheroid

Mevalonate Pathway Provides Ubiquinone to Maintain ... · pyrimidine nucleotide biosynthesis and induced oxidative stress and apoptosis in p53-deficient cancer cells in spheroid

Nucleotide Biosynthesis: Pyrimidine Synthesis; how does ... · the Urea Cycle. ATCase, and therefore the activity of CPS-II, is localized to the cytoplasm and prefers glutamine as

Nucleotide Biosynthesis: Pyrimidine Synthesis; how does ... · the Urea Cycle. ATCase, and therefore the activity of CPS-II, is localized to the cytoplasm and prefers glutamine as

FCH 532 Lecture 29 Chapter 28: Nucleotide metabolism Quiz on Mon (4/16): IMP synthesis-Purine synthesis Quiz on Wed(4/18): Pyrimidine biosynthesis/regulation.

FCH 532 Lecture 29 Chapter 28: Nucleotide metabolism Quiz on Mon (4/16): IMP synthesis-Purine synthesis Quiz on Wed(4/18): Pyrimidine biosynthesis/regulation.