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Brand and

Generic name

Classification Action Side effects Contraindications Nursing

Responsibility

GENERIC

NAME:

Azathioprine

BRANDNAME: Azasan

and Imuran.

Immunosuppressa

nt

Azathioprine is an

immunosuppressa

nt, which inhibits

DNA, RNA and

protein synthesisand antagonises

purine synthesis. Italso inhibits

mitosis and

interferes with

cellular

metabolism of

susceptibleorganisms.

Azathioprine inj

should be

discontinued assoon as oraltherapy can be

introduced

Blood - Decreased

white blood cells

and platelets.

Gastrointestinal -Nausea, vomiting,

diarrhea andabdominal pain.

Miscellaneous -

Rash, hair loss,

fever, joint pain,

diarrhea, negativenitrogen balance

and reversible

interstitial lung

inflammation.

Hypersensitivity;

previous treatment

with alkylating

agents; pregnancy,

lactation.

-Give drug IV if

oral

administration i

not possible;

switch to oralroute as soon as

possible.

-Administer in

divided daily

doses or with

food if GI upset

occurs.

-BLACK BOX

WARNING: M

itor blood count

regularly; sever

hematologic

effects may

require the

discontinuation

therapy; increas

risk of neoplasia

-Take drug in

divided doses

with food if GI

upset occurs.

-Avoid

infections; avoid

crowds or peopl

who have

infections. Notif

your physician a

once if you are

injured.

-Notify your

health care

provider if you

think you arepregnant or wish

to become

pregnant, or if

you are a man

whose sexual

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partner wishes t

become pregnan

-You may

experience theseside effects:

Nausea, vomitin(take drug in

divided doses or

with food),

diarrhea, rash.

-Report unusualbleeding or

bruising, fever,

sore throat,

mouth sores,

signs of infectio

abdominal painsevere diarrhea,

darkened urine

pale stools,

severe nausea an

vomiting.