Medical University of South Carolina NIH Roadmap November 1, 2004
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Transcript of Medical University of South Carolina NIH Roadmap November 1, 2004
Medical University of South Carolina
NIH Roadmap
November 1, 2004
Dr. Patricia A. GradyDirector, National Institute of Nursing Research
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NIH Roadmapwww.nihroadmap.nih.gov
NIH Roadmap
• Conception• Infrastructure• Progress• Implications
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Roadmap Questions
• What are today’s scientific challenges?
• What are the roadblocks to progress?• What do we need to do to overcome roadblocks?
• What can’t be accomplished by any single Institute – but is the responsibility of NIH as a whole?
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Imperatives for NIH
• Accelerate pace of discoveries in life sciences
• Translate research more rapidly from laboratories to patients and back
• Develop novel approaches in orders of magnitude never before undertaken
• Develop new strategies: NIH Roadmap
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Bench Bedside Practice
The Problem
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Bedside Practice
New Pathways to Discovery
• Building Blocks and Pathways
• Molecular Libraries• Bioinformatics• Computational
Biology• Nanomedicine
Bench
NIH Roadmap Theme:New Pathways to Discovery
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NIH Roadmap Theme:Research Teams of the Future
Bedside Practice
• Building Blocks and Pathways
• Molecular Libraries• Bioinformatics• Computational
Biology• Nanomedicine
Research Teams of the Future
Interdisciplinary Research TeamsPioneer Awards
Public-Private Partnerships
Bench
New Pathways to Discovery
Building Blocks and Pathways
Molecular LibrariesBioinformaticsComputational
BiologyNanomedicine
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NIH Roadmap Theme:Re-engineering Clinical Research
Bedside PracticeBench
Re-Engineering the Clinical Research Enterprise
New Pathways to Discovery
Building Blocks and Pathways
Molecular LibrariesBioinformaticsComputational
BiologyNanomedicine
Research Teams of the Future
Interdisciplinary Research TeamsPioneer Awards
Public-Private Partnerships
Integrated Research NetworksClinical Research Informatics
NIH Clinical Research AssociatesClinical outcomes
Clinical Research PolicyTrainingTranslational Research
Initiatives
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Criteria for Roadmap Initiatives
• Is it ‘transforming’ -- will it change how or what biomedical research is conducted in the next decades?
• Would its outcome enhance the ability of all Institutes and Centers to achieve their missions?
• Can the NIH afford NOT to do it?• Will it be compelling to our stakeholders,
especially the public? • Is it something that no other entity can or will
do?
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NIH Roadmap for Medical Research
New Pathwaysto Discovery
Re-engineering theClinical Research Enterprise
Research Teamsof the Future
NIH
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NIH Roadmap for Medical Research FY2004 Funding
New Pathwaysto Discovery
Re-engineering the ClinicalResearch Enterprise
Research Teamsof the Future
NIH
$64.1
$26.6 $37.6
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FY04 FY05 FY06 FY07 FY08 FY09 Total
Pathways to
Discovery 64 137 169 182 209 188 948
Research Teams 27 39 44 92 96 93 390
Clinical Research 38 61 120 174 214 227 833
Total 128 237 332 448 520 507 2172
Roadmap Funding
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NINR Themes
• Identifying effective strategies to reduce health disparities
• Changing lifestyle behaviors for better health
• Managing the effects of chronic illness to improve quality of life
• Harnessing advanced technologies to serve human needs
• Enhancing the end-of-life experience for patients and their families
• New research teams
• New paths to discovery
• Re-engineering the clinical research enterprise
NIH Roadmap Themes
Integrating the NIH Roadmap at NINR
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Integrating the NIH Roadmap at NINR
• What are the science gaps that nurse researchers in particular can fill?
• What areas of the Roadmap are we already addressing?
• What directions should we take to be Roadmap leaders?
• What will spur the community to be a part of the Roadmap?
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NINR Roadmap Integration
NIH Roadmap Link
NINR Roadmap Integration
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NIH Roadmap
“Early success claimed for Zerhouni's NIH roadmap”
October 14th Briefing: NIH Roadmap for Medical Research
One Year Later
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Research Teams of the Future:A Closer Look
New Pathways to DiscoveryBuilding Blocks, Biological Pathways, and Networks
Molecular Libraries & Imaging
Structural Biology
Bioinformatics & Computational Biology
Nanomedicine
Research Teams of the Future High-Risk ResearchInterdisciplinary Research Public Private Partnerships
Re-Engineering the Clinical Research Enterprise Clinical Research Policy Analysis and Coordination
Integration of Clinical Research NetworksEnhance Clinical Research Workforce TrainingEnabling Technologies for Improved Assessment of Clinical OutcomesRegional Translational Research CentersTranslational Research Service CoresClinical Center’s Clinical Research Training Program
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• Interdisciplinary Research– Patricia Grady, NINR – Ken Olden, NIEHS– Larry Tabak, NIDCR
• High-risk Research – Ellie Ehrenfeld, NIAID– Stephen Straus, NCCAM
• Public-Private Partnerships– Andy von Eschenbach, NCI – Richard Hodes, NIA
Research Teams of the Future:Working Groups and Co-Chairs
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NIH Director's Pioneer Award
Research Teams of the Future
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Research Teams of the Future
Pioneer Award Criteria:– Evidence of scientific innovation and creativity;– Testimony of intrinsic motivation, enthusiasm and
intellectual energy; and– Potential for scientific leadership and evidence of, or
potential for, effective communication skills.
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Research Teams of the Future
Interdisciplinary Research – Planning grants for interdisciplinary
research centers (P20 Centers)– Innovative training programs– Development of methodologies aimed at
integrating behavioral and social science into interdisciplinary research
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Research Teams of the Future
P20 Exploratory Centers for Interdisciplinary Research
– Lower organizational barriers that impede research
– Enable scientists to conduct research across disciplines
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P20 Exploratory Centers—Examples• Behavioral Epidemiology
– Integrate theoretical methodological and analytic aspects of economic sciences, population sciences, and behavioral sciences to develop a new approach to discovery and intervention in youth vulnerable to HIV/AIDS
• Imaging Genetics– Draw from genomics, image analysis, statistics, and
neuropsychiatry to improve diagnosis and treatment of mental illness and other brain disorders
Research Teams of the Future
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P20 Exploratory Centers—Examples• Antimicrobial resistance
– Integrate new disciplines to address the fast growing problem of antimicrobial resistance using novel new strategies developed by interdisciplinary research teams using long-term strategies
• Obesity research– Integrate disciplines of neuroendocrinology, genetics,
and lipid& intermediate metabolism , and clinical epidemiology to better treat and prevent obesity
Research Teams of the Future
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Interdisciplinary Training Programs• New funding mechanisms
– Support interdisciplinary work from undergraduate students through postdoctoral researchers
• Provide foundation for diverse interdisciplinary scientific teams necessary for success of future endeavors
• Include short and long term:– Training– Curriculum– Methodological development
Research Teams of the Future
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Interdisciplinary Training Programs-Examples
• Clinical Research Experience for Engineers– Undergraduate engineers engage in clinical research
projects with clinical and bioengineering mentorship,
• Regenerative Sciences Training Program– Biologists, engineers, and clinicians augment training via
didactic and research experiences with focus on musculoskeletal systems
• Clinical Biodetective Training– Trainees to develop novel methods for detection of disease
states, markers of good health, and therapeutic markers
Research Teams of the Future
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Research Teams of the Future
Private-Public Partnerships
NIH
Nonprofit Organizations
PrivateIndustry
Committee Co-Chairs
Dr. Patricia A. GradyDirector, National Institute of Nursing Research
Dr. Yvonne T. MaddoxDeputy Director, National Institute of Child Health & Human Development
Public Trust Initiative
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Public Trust Initiative
Goal– To improve the public’s health by
promoting public trust in bio/medical and behavioral research
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Public Trust Initiative
Defining Public Trust– Public
• Individuals, patients, families, and communities.
– Trust• “Confidence placed by the people in an
institution or process”
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Public Trust Initiative
NIH cannot control the public’s perceptions in the area of research…
…but we at NIH can improve how we communicate and interact
with the public.
Health problem in a patient
Epidemiological studies: Who is affected? Surveys, population studies
Basic Research: What are the mechanisms?
Drug/Medical Device Discovery and Development
Drug/Medical Device Testing: Efficacy and toxicity/complications
Clinical Trials: Testing on volunteers
The presence of an untreatable problem generates a research need.
Information obtained from basic research generates ideas for drugs, devices, or techniques to treat the problem.
A safe, effective drug, device, or treatment is then used for treatment of the problem.
Drugs, devices, and treatments are tested for safety and efficacy, first in laboratory assays, then in animals, finally in human volunteers
The entire process from initiation of a research project to development of a treatment may take many years and cost hundreds of millions of dollars.
Studies performed in humans Studies performed in the laboratory Studies performed in animals
Where are the Issues of Public
Trust?
Access
to informatio
n
Healt
h
impact
Communicati
on of results
Translation
to public
domain
Harmon
i-zation
Informe
d consent
Communit
y linkages
Communit
y issues
The Process of Biomedical Research
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Public Trust Initiative
Obtaining a Baseline: Initial Steps– Inventory of current NIH activities
• Ongoing and planned activities• Research related to public trust
– National survey of the public to discern issues regarding public trust and the research enterprise
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Public Trust Initiative
Categories of Public Trust– Clinical research involving human
participation– Including the public in IC business– Promoting the visibility of NIH– Teaching and developing course materials
for science education– Education and outreach programs for
extramural and intramural clinical and research communities
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Public Trust Website
http://publictrust.nih.gov
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NIH Roadmap Website
http://nihroadmap.nih.gov/