The NIH Roadmapfor Medical Research

nihroadmap.nih.gov

Evolving Health Challenges

Acute to Chronic Conditions

Health Disparities

Emerging Diseases

Aging Population

Biodefense

Why was there a need for a Roadmap?

Position NIH to address evolving public health challenges

Accelerate the pace of discoveries

Develop more rapid translation from laboratories to patients and back

NIH Roadmap Goals..

Accelerate basic research discoveries and speed translation of those discoveries into clinical practice

Explicitly address roadblocks that slow the pace of medical research in improving the health of the American people

NIH opportunities and challenges…

Revolutionary and rapid changes in science

Increasing breadth and growth of NIH mission

NIH is a complex organization made up of 27 institutes and centers, as well as multiple program offices, structured by Disease, Organ, Life stage, Discipline ….

Rapid convergence of science Multi- and interdisciplinary research

Multi- and Interdisciplinary Research will be Required to Solve the “Puzzle” of Complex Diseases and Conditions

GenesBehaviorDiet/NutritionInfectious agentsEnvironment Society???

How was the Roadmap developed?

Extensive consultations with stakeholders, scientists, health care providers

Discussions addressed: What are today’s scientific challenges? What are the roadblocks to progress? What do we need to do to overcome roadblocks? What can’t be accomplished by any single Institute

but is the responsibility of NIH as a whole?

What is the NIH Roadmap? A framework of priorities that the NIH

as a whole must address in order to optimize its entire research portfolio.

A set of initiatives that are central to extending the quality of healthy life for people in this country and around the world.

A vision for a more efficient and productive system of biomedical and behavioral research.

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Roadblocksto technology transfer

Three themes emerged….

New Pathwaysto Discovery

Re-engineering theClinical Research

Enterprise

Research Teamsof the Future

NIH

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New Pathways to Discovery

Building Blocks, Biological Pathways, & Biological Networks

Molecular Libraries & Molecular Imaging

Bioinformatics & Computational Biology

Structural Biology

Nanomedicine

nihroadmap.nih.gov/newpathways/index.asp

New Pathways to Discovery

Grasping the emerging complexity of biology Understanding biological systems Accessing biological data, technologies, and other

scientific resources Promoting Multi-and Interdisciplinary research

Initiatives within this theme address Initiatives within this theme address technologies and approaches necessary to technologies and approaches necessary to meet contemporary research challenges.meet contemporary research challenges.

Bioinformatics and Computational Biology: National Centers for Biomedical Computing Partnerships of:

Computer scientists Biomedical computational scientists Experimental and clinical biomedical and behavioral

researchers Focused on software rather than hardware Each National Center to have Driving Biological

Projects Programs in preparation for partnerships between

individual investigators and National Centers

www.bisti.nih.gov/ncbc/index.cfm?

The FY-2004 NIH Roadmap -National Centers for Biomedical Computing: Physics-based Simulation of Biological Structures

Russ Altman, M.D., Ph.D. Stanford University

National Alliance for Medical Imaging ComputingRon Kikinis, M.D.Brigham and Women's Hospital

Informatics for Integrating Biology and the BedsideIsaac Kohane, M.D., Ph.D.Brigham and Women's Hospital

Center for Computational BiologyArthur Toga, Ph.D. University of California at Los Angeles

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Interdisciplinary Research Teams

Pioneer Award

Public-Private Partnerships

Research Teams of the Future

Building Blocks, Biological Pathways, & Biological Networks

Molecular Libraries & Molecular Imaging

Bioinformatics & Computational Biology

Structural Biology

Nanomedicine

nihroadmap.nih.gov/researchteams/index.asp

Research Teams of the Future

Encouraging Multi- and Interdisciplinary teams Supporting larger, coordinated, resource sharing teams Preserving investigator-initiated strategy Promoting investigators to take creative, unexplored

avenues of research

Initiatives within this theme provides Initiatives within this theme provides mechanisms for interdisciplinary research, mechanisms for interdisciplinary research, high-risk strategies and public-private high-risk strategies and public-private partnerships.partnerships.

NIH Director’s Pioneer Award New program to support individuals with

untested, potentially groundbreaking ideas!

Encourages innovation, high risk taking

Totally new application and peer review process

Expected to be highly competitive

Expanded eligibility – (not only traditional biomedical investigators)

Provides $500,000 per year for 5 years

nihroadmap.nih.gov/pioneer/

NIH Director’s Pioneer Award Laurence F. Abbott, Ph.D., Brandeis University, Waltham, MA

George Q. Daley, M.D., Ph.D., Children's Hospital, Boston, MA

Homme W. Hellinga, Ph.D., Duke University Medical Center, Durham, NC

Joseph McCune, M.D., Ph.D., J. David Gladstone Institutes, San Francisco, CA

Steven L. McKnight, Ph.D., UT Southwestern Medical Center, Dallas, TX

Chad Mirkin, Ph.D., Northwestern University, Evanston, IL

Rob Phillips, Ph.D., California Institute of Technology, Pasadena, CA

Steven R. Quake, Ph.D., California Institute of Technology, Pasadena, CA

Sunney Xie, Ph.D.. Harvard University, Cambridge, MA

nihroadmap.nih.gov/pioneer/Recipients04.aspx

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Clinical Research Networks, & NECTAR

Dynamic Assessment of Patient-Reported Chronic Disease Outcomes

Clinical Research Policy Analysis & Coordination

Clinical Research Workforce Training

Translational Research

Interdisciplinary Research Teams

Pioneer Award Public-Private Partnerships

Re-engineering the Clinical Research Enterprise

Building Blocks, Biological Pathways & Biological Networks

Molecular Libraries & Molecular Imaging

Bioinformatics & Computational Biology

Structural Biology

Nanomedicine

nihroadmap.nih.gov/clinicalresearch/index.asp

Reengineering the Clinical Research Enterprise

Promoting better integration of existing clinical research networks, including the National Electronics Clinical Trials and Research (NECTAR) network

Supporting translational research Encouraging the development of technologies to improve

the assessment of clinical outcomes Harmonizing regulatory processes Enhancing training for clinical researchers

Initiatives within this theme address the need Initiatives within this theme address the need for developing new strategies to enhance the for developing new strategies to enhance the infrastructure and capacity for clinical research infrastructure and capacity for clinical research and reenergize the clinical research workforce.and reenergize the clinical research workforce.

NIH RoadmapPercent of Total NIH Budget – FY-2004

FY-2005 Request = $28,757 Million

Non-Roadmap99.2%

($28,520 Million)

Roadmap0.8%

($237 Million)

“How does the NIH Roadmap benefit research funded by NIH ICs?” Speeding removal of major and fundamental

roadblocks common to all diseases

Institutes working together to solve issues

This is a common trans-NIH pool of transforming investments open to all disease areas and all investigators for competition

The NIH Roadmap:A Work in Progress

nihroadmap.nih.gov