Mark Nelson - Potassium channels and neurovascular coupling

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    Vlptlcjlr :7, :7>6

    Vlf`hm Khtlrhntk`hni R`resd`p `h FNMNVKI

    Cnre Hlis`h

    Jurikhbt`h, _lrc`ht

    C`uht Cnhsoklim \hkvlrskty `o _lrc`ht

    W`tnsskuc fdnhhlis, Hlur`vnsfuinr F`upikhb, FNMNVKI

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    "Nhm wdnt pdyskfknhs sny nj`ut mkslnsl ks nppikfnjil dlrl1 tdnt

    nt tdl jlbkhhkhb n mkslnsl ks lnsy t` furl jut mkookfuit t`

    mknbh`sl5 jut ns tkcl pnssls, h`t dnvkhb jllh trlntlm `rrlf`bhkzlm nt tdl `utslt, kt jlf`cls lnsy t` mknbh`sl jut

    mkookfuit t` furl. ]dl sncl tdkhb `ffurs kh noonkrs `o stntl5 o`r jy

    rlf`bhkzkhb or`c nonr tdl mkslnsls tdnt nrl sprlnmkhb kh tdl

    stntl (wdkfd ks n bkot bkvlh `hiy t` n prumlht ruilr), tdly fnh jl

    furlm qukfeiy5 jut wdlh tdly nrl h`t rlf`bhkzlm nhm nrl ilot t`

    br`w t` tdl lxtlht tdnt lvlry`hl rlf`bhkzls tdlc, tdlrl ks h`

    i`hblr nhy furl.

    Hkff`i` Cnfdknvliik(nen Onjrkfl Mnjlrtrnhm)

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    O`hmntk`h Ilmufq ]rnhsntinhtkf Hltw`re `o Lxfliilhfl

    Wntd`blhlsks `o Vcnii _lssli Mkslnsl `o tdl Jrnkh

    Lur`plnh F``rmkhnt`r

    Nhhl A@\]LI (Ornhfl)

    KHVLZC Zlslnrfd Mkrlft`r

    Blhltkfs `o _nsfuinr Mkslnsls Inj`rnt`ry-

    KHVLZC

    \hkvlrskty Wnrks2-Mlhks Mkmlr`t

    >7 nvlhul ml _lrmuh, 27 Wnrks, Ornhfl

    nhhl.a`utliGuhkv-pnrks-mkmlr`t.or

    Wd`hl1 7>

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    Jrnkh survkvni

    Nut`rlbuintk`h1 Cnkhtnkhkhb f`hstnhtji``m oi`w kh rlsp`hsl t` ji``m

    prlssurl oiuftuntk`hs.

    Hlur`vnsfuinr f`upikhb1 Zlbk`hnif`upikhb `o flrljrni ji``m oi`w t` tdl

    cltnj`ikf mlcnhm `o hlur`hs.

    ]dl jrnkh p`sslssls khtrkhskf clfdnhkscs jy wdkfd ktsvnsfuinr suppiy fnh jl vnrklm i`fniiy kh f`rrlsp`hmlhfl

    wktd i`fni vnrkntk`hs `o ouhftk`hni nftkvkty (Z`y nhm

    Vdlrrkhbt`h, >4;7)

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    Kcpikfntk`hs `o hlur`vnsfuinr

    f`upikhb

    Ouhftk`hni jrnkh kcnbkhb jy c`hkt`rkhb

    i`fni flrljrni ji``m oi`w wktd oCZK.

    \hmlrstnhmkhb `o jrnkh mkslnsls tdnt nrl

    nss`fkntlm wktd hlur`vnsfuinr

    mysouhftk`h, khfiumkhb str`el, Nizdlkclrs,

    vnsfuinr mlclhtkn, dyplrtlhsk`h.

    C`muintk`h `o hlurni pr`flsskhb.

    ]d H i \ k

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    ]dl Hlur`vnsfuinr \hkt

    Nrtlrk`ils kh tdl jrnkh nrl lhfnslm jy nstr`fytkf

    pr`flssls

    Knmlf`in,

    Hnturl

    Zlvklws,

    Hlur`sfklhfl,

    :77=

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    ]dl Hlur`vnsfuinr \hkt

    >7 c

    Nstr`fytl

    lhmollt

    Vc``td cusfil

    WlrkfytlLhm`tdlikuc

    Hlur`hs

    Nstr`fytl lhmollt f`cpiltliy lhfnsl tdl khtrnflrljrni vnsfuinturl nhm nrl tdus

    uhkquliy p`sktk`hlm t` mlikvlr skbhnikhb c`ilfuinr t` tdl uhmlriykhb sc``td

    cusfil

    Lhm`tdlikni fliis ikhl tdl iuclh `o tdl nrtlrk`ils, nhm f`ccuhkfntl ji``m-j`rhlskbhnis t` sc``td cusfil t` noolft t`hl

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    N pinstkf lcuisk`h wns khalftlm kht` tdl jrnkh vlsslis, nhm

    jrnkh pnrlhfdycni tkssul wns mkss`ivlm

    (Qi`e`vkf & Npuzz`, >;;45 Ikppkhf`tt Rkiikncs & Rkiekhs)

    Hlur`vnsfuinr f`upikhb

    Muhh, E. C. nhm C. ]. Hlis`h (:7>7). "W`tnsskuc Fdnhhlis nhm

    Hlur`vnsfuinr F`upikhb." Fkrfuintk`h A`urhni 2=(=)1 ?74-?>?

    Ilvli `o nstr`fytkf lhmo``tFn:+ mltlrckhls wdltdlr nh

    nmanflht nrtlrk`il mkintls `r

    f`hstrkfts mlplhmkhb

    `h plrkvnsfuinr E+.

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    Khdlrktlm scnii vlssli mkslnsl fnuskhb

    str`el nhm sujf`rtkfni vnsfuinr mlclhtkntdnt stnrts kh lnriy nmuitd``m nhmpr`brlssls `vlr tkcl.

    FNMNVKI

    Fnuslm jy cutntk`hs kh H@]FD6 blhl

    Or`c Fdnjrknt D lt ni. Inhflt Hlur i. :77; Aui54(2)1?=6-7 nhm >>

    rlqukrlm o`r ikbnhm jkmkhb

    Clfdnhkscs ikhekhb H`tfd6 cutntk`h t` vnsfuinr kcpnkrclht rlcnkh lhkbcntkf

    Flrljrni

    Nut`s`cni

    M`ckhnht

    Nrtlrk`pntdy wktd

    Vujf`rtkfni

    Khonrfts &

    Iluf`lhflpdni`pntdy

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    ]dl c`usl c`mli

    I`ss `o H`tfd6 fnusls strufturni nhm ouhftk`hni nitlrntk`hs `o scnii nrtlrkls, jut m`ls

    h`t fnusl FNMNVKI pntd`i`by. (Iku lt ni Fkrf Zls :7>7)

    Nhhl A`utli nhm f`w`relrs uslm n W>-mlrkvlm nrtkokfkni fdr`c`s`cl-jnslmtrnhsblhlsks t` `vlrlxprlss H`tfd6 kh nh lhm`blh`us-ikel lxprlssk`h pnttlrh. Ikhl

    >:; `vlrlxprlssls (x=) rnt wkim-typl H`tfd6 blhl, nhm ikhl 44 `vlrlxprlssls (x=) n

    FNMNVKI o`rc H`tfd6Z>?;F.

    H`h-]b ]bH`tfd6R] ]bH`tfd6Z>?;F

    H`tfd6

    H`tfd6

    H`tfd6

    H`tfd6H`tfd6

    H`tfd6

    H`tfd6H`tfd6

    H`tfd6 H`tfd6

    H`tfd6

    H`tfd6

    H`tfd6Z>?;F H`tfd6

    H`tfd6

    H`tfd6Z>?;FH`tfd6Z>?;F

    H`tfd6Z>?;F

    H`tfd6Z>?;FH`tfd6Z>?;F

    H`tfd6Z>?;F

    H`tfd6Z>?;F

    A`utli N lt ni. A Fikh Khvlst. (:7>7) >:7(:)1=66-=

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    [`uhb ]bZ>?;F (7) >:7(:)1=66-=

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    Z`k Fn:+ c`vkls `hiy

    Wnrlhfdycni nrtlrk`il wktd pnrlht ckmmil flrljrni nrtlry

    (Zlm, nqunp`rkh = (nstr`fytl) stnkhkhb)

    (Or`c Dnhhnd lt ni., AFJOC, :7>>)

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    Clcjrnhl p`tlhtkni nhm mkncltlr clnsurlclhts `o prlssurkzlm

    pnrlhfdycni nrtlrk`il

    Lmbl mltlftk`hsystlc

    Wrlssurkzlm

    WN (=7 cc Db)

    ckfr`lilftr`ml

    Fnhhuin

    C`hkt`r]kl

    Clcjrnhl p`tlhtkni

    (c_)

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    \prlbuintk`h `o p`tnsskuc

    fdnhhli nftkvkty t` `pp`slkhfrlnsls kh khtrnvnsfuinr

    prlssurl

    `hl wny NH@_N

    FNMNVKI pnrlhfdycni nrtlrk`ils f`hstrkft ilss t`

    khtrnvnsfuinr prlssurl

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    Zlskstnhfl-skzlm clslhtlrkf nrtlrkls mkspiny

    h`rcni cy`blhkf t`hl

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    K`h fdnhhli f`htr`i `o sc``td cusfil clcjrnhl p`tlhtkni

    nhm khtrnfliiuinr fnifkuc

    Ev1 _`itnbl-mlplhmlht p`tnsskuc fdnhhli.

    JEFn1 Inrbl-f`hmuftnhfl, fnifkuc-slhsktkvl p`tnsskuc fdnhhli.

    Ekr1 Vtr`hb khwnrm rlftkoklr p`tnsskuc fdnhhli. Nftkvntlm jy lxtlrhni E+ nhm clcjrnhl

    p`tlhtkni dyplrp`inrkzntk`h.KEFn1 Khtlrclmkntl f`hmuftnhfl, fnifkuc-nftkvntlm p`tnsskuc fdnhhli.

    VEFn1 Vcnii f`hmuftnhfl, fnifkuc-nftkvntlm p`tnsskuc fdnhhli.

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    Lxtlrhni E+` ks n p`tlht nhm rnpkm vns`mkint`r nhm f`hstrkft`r

    `o prlssurkzlm (47 cc Db) flrljrni nrtlrkls

    Eh`t lt ni., A. Wdysk`i., >;;4

    >> >?:>

    Hks`imkpkhl(>7 hC)

    Lxtlrhni UE S(cC)

    +

    :? 6>6? =>

    4>?>

    677

    Nstr`fytkf

    Lhmo``t Fnifkuc

    JE

    Wlrkvnsfuinr E+

    Mkintk`h

    9:7 cC

    F`hstrkftk`h

    8:7 cC

    Fnifkuc fdnhhli khdkjkt`r

    Mkintk`h t`Ekr:.> nftkvntk`h

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    Clcjrnhl p`tlhtkni `o vnsfuinr sc``td cusfil mltlrckhls

    nrtlrkni mkncltlr nhm dlhfl ji``m oi`w

    (Lxtlrhni E+ rlbuintls clcjrnhl p`tlhtkni)

    Eh`t & Hlis`h, A Wdysk`i >;;4

    Fnifkuc fdnhhlis khdkjktlm

    Mlntd

    Ikol

    Mlntd

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    Mkintk`h nhm f`hstrkftk`h t` lilvntk`h `o UE+S7 or`c 6 t` ?7

    cC nrl uhnoolftlm kh FNMNVKI

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    Clcjrnhl p`tlhtkni `o nrtlrk`inr sc``td cusfil or`c

    FNMNVKI ckfl ks dyplrp`inrkzlm nt =7 cc Db

    H`h-]b

    ]bF`htr`i

    ]bZ>?;F

    _c (c_)

    -6=

    7.?

    -6.?

    -==.:

    >.=

    =7

    cc Db

    -

    -

    >7

    cc Db

    `hl wny NH@_N

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    K`h fdnhhli f`htr`i `o sc``td cusfil clcjrnhl p`tlhtkni

    nhm khtrnfliiuinr fnifkuc

    Ev1 _`itnbl-mlplhmlht p`tnsskuc fdnhhli.

    JEFn1 Inrbl-f`hmuftnhfl, fnifkuc-slhsktkvl p`tnsskuc fdnhhli.

    Ekr1 Vtr`hb khwnrm rlftkoklr p`tnsskuc fdnhhli. Nftkvntlm jy lxtlrhni E+ nhm clcjrnhl

    p`tlhtkni dyplrp`inrkzntk`h.KEFn1 Khtlrclmkntl f`hmuftnhfl, fnifkuc-nftkvntlm p`tnsskuc fdnhhli.

    VEFn1 Vcnii f`hmuftnhfl, fnifkuc-nftkvntlm p`tnsskuc fdnhhli.

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    Ncpd`tlrkfkh J

    p`rl

    Mkrlft clnsurlclhts `o p`tnsskuc fdnhhli nftkvkty uskhb

    tdl pntfd fincp tlfdhkqul

    Nmnptlm or`c dttp1//pntfd-fincp.kho`/tlfdhkquls/tlfdhkquls.dtc

    -47 c_ -27 c_

    +?7 c_

    -=7 c_

    Lxplrkclht f`hmuftlm kh tdl njslhfl `o

    Fn:+, nhm kh prlslhfl `o JE ji`felr

    pnxkiikhl

    @jalftkvl1 f`cpnrl furrlhts or`c

    ks`intlm nrtlrk`inr sc``td cusfil flii

    likfktlm jy v`itnbl puisls or`c

    -27 c_ t` +?7 c_.

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    Furrlht mlhsktkls nrl mkoolrlht or`c -67 c_ t` ?7 c_

    Furrlht mlhskty `o v`itnbl-mlplhmlht E+ fdnhhlis ks brlntlr kh FNMNVKI

    (flii clcjrnhl suronfl nrln ks uhnoolftlm)

    `hl wny NH@_N

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    Wrlssurl-khmuflm f`hstrkftk`hs nrl uhnitlrlm nt i`wlr prlssurls (967 cc Db)

    jut cy`blhkf t`hl ks mlfrlnslm nt pdysk`i`bkfni prlssurls kh j`td pkni nrtlrklsnhm pnrlhfdycni nrtlrk`ils (WNs) or`c FNMNVKI ckfl.

    Kcpikfntk`h1 Wrlssurl-mlplhmlht clfdnhksc ks nitlrlm kh FNMNVKI.

    D`wlvlr, f`htrnftkil ouhftk`h ks prlslrvlm wktd mkncltlr fdnhbls t`

    p`tnsskuc jlkhb uhnitlrlm.

    WNs or`c FNMNVKI ckfl sd`w n c`rl dyplrp`inrkzlm clcjrnhl p`tlhtkni nt

    =7 cc Db. JE, KE, VE fdnhhlis nhm lH@V ouhftk`h m` h`t npplnr mkoolrlht kh FNMNVKI

    c`usl.

    _`itnbl-mlplhmlht p`tnsskuc (Ev) fdnhhli furrlht mlhskty ks lilvntlm kh

    flrljr`vnsfuinr sc``td cusfil fliis or`c FNMNVKI ckfl.

    Wrlssurl _c

    mlp`inrkzntk`hUFn:+Sk Mkncltlr FJO

    Ev

    JE, LF ouhftk`h (KE, VE, lH@V)

    Flrljrni Ji``m Oi`w nut`rlbuintk`h ks nitlrlm kh

    FNMNVKI

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    Vujnrnfdh`km dlc`rrdnbl ji``m khfrlnsls prlssurl-khmuflm f`hstrkftk`hs

    tdr`ubd m`whrlbuintk`h `o v`itnbl-mlplhmlht p`tnsskuc fdnhhlis

    Cnsny` E`kml

    Nmrknh J`hlv

    Bl`rbl Rliicnh

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    E`kml lt ni.NAW:772Ksdkbur` lt ni. Fkrf Zls :77?

    Ev fdnhhli trnookfekhb ks rlbuintlm jy cltnii`pr`tlkhnsl (CCW) tdr`ubd

    dlpnrkh jkhmkhb lpkmlrcni br`wtd onft`r ikel br`wtd onft`r (LBOZ)

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    Dlpnrkh-jkhmkhb Lpkmlrcni Br`wtd Onft`r (DJ-LBO)

    khmufls Ev furrlht supprlssk`h

    E`kml lt ni.NAW Dlnrt Fkrf Wdysk`i. :772 Vlp5:;6(6)1D>2

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    Wnkrlm ]-tlst

    DJ-LBO rlst`rls cy`blhkf rlsp`hsl kh flrljrni

    nrtlrkls or`c FNMNVKI c`usl

    F

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    Or`c E`kml :772

    Lxflss `o H`tfd6LFM njh`rcniiy stnjkikzls ]KCW6

    (B@C o`rcntk`h), wdkfd khfrlnsls Ev fdnhhlis nt tdl

    clcjrnhl t` `pp`sl prlssurl-khmuflm f`hstrkftk`h

    sdlmmkhb

    H`tfd6LFM

    H`tfd6KFMBlhl lxprlssk`h (Ev >.

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    ]w` nppr`nfdls t` rlst`rl cy`blhkf t`hl kh

    FNMNVKI

    Blhltkf rlmuftk`h `o ]KCW-6

    rlst`rls cy`blhkf t`hl kh

    p`stlrk`r flrljrni nrtlrkls(kh Wnrks)

    Wdnrcnf`i`bkf nftkvntk`h `o LBOZ

    rlst`rls cy`blhkf t`hl kh

    pnrlhfdycni nrtlrk`ils(kh Jurikhbt`h)

    N clfdnhksc jy wdkfd H`tfd6 cutntk`h ilnms t` n vnsfuinr

    kcpnkrclht

    Wilk`tr`pkf loolft `o H`tfd6Z>?;F vkn

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    I`fni ji``m oi`w

    Nstr`fytl lhmo``t

    Vc``td cusfil

    Lhm`tdlikuc

    JE

    E+E+E+

    F`hstrkftk`h

    Mkintk`h

    E+

    Ekr

    LC

    WIN:NN

    Wr`stnbinhmkhs/

    pr`stnfyfikh

    Mkintk`h

    I`fni ji``m oi`w

    ++

    -

    :7-DL]L

    LL]

    Fn:+ wnvl

    Hlur`hni nftkvkty

    Fnrt``h or`c Br` Eiktbnnrm W`vislh

    Wilk`tr`pkf loolft `o H`tfd6Z>?;F vkn

    B@C0

    B@C o`rcntk`h

    B i @ k dkik C t k i (B@C) m t t m

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    > c

    Brnhuinr @sck`pdkikf Cntlrkni (B@C) nrl mltlftlm

    jltwllh sc``td cusfil fliis nhm nstr`fytkf lhmo``t

    Or`c Nhhl A`utli

    CL]D@MV

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    Jrnkh sikfls i`nmlm wktd

    Oiu`-=.NC

    . LOV, Fn:+ uhfnbkhb

    >. F`r`hni jrnkh sikfls or`c hl`hntni rnts W; (>:< hC )

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    Hlur`vnsfuinr f`upikhb1 Lilvntk`h `o nstr`fytkf lhmo``t

    Fn:+ fnusls vns`mkintk`h

    LOV 3 Lilftrkfni Oklim Vtkcuintk`h

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    LOV-khmuflm mkintk`h ks rlmuflm kh

    FNMNVKI ckfl

    :

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    LOV-khmuflm Fn:+ khfrlnsl kh nstr`fytkf

    lhmo``t ks rlmuflm kh FNMNVKI ckfl

    Onstlr UFn:+S mlfny kh lhmollt or`c

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    E 7.76:>

    Dnio Ikol >:.?> 4.>; 2.

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    R`rekhb Dyp`tdlsks1

    Lnriy f`hslqulhfl `o FNMNVKI ks

    uprlbuintk`h `o Ev >.< lxprlssk`h nhm nftkvktywdkfd ilnms t` f`cpr`ckslm nut`rlbuintk`h.

    Lilvntk`h `o tdl cltnii`pr`tlkhnsl ]KCW6 kh

    B@C ilnms t` nh khfrlnsl kh suronfl

    lxprlssk`h `o Ev fdnhhlis.

    Mlfrlnslm cy`blhkf t`hl w`uim mkckhksd

    vns`mkint`r fnpnfkty, nhm tdlrljy

    hlur`vnsfuinr f`upikhb. FNMNVKI ikeliy nttlhuntls nstr`fytl lhmo``t

    fnifkuc skbhnikhb t` mlflnsl hlur`vnsfuinr

    f`upikhb.

    N e i m t

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    Nfeh`wilmblclhts

    Ouhmkhb1Nclrkfnh Dlnrt Nss`fkntk`h, ]`tcnhClmkfni Zlslnrfd ]rust, Iuhmjlfe O`uhmntk`h

    Hntk`hni Khstktutl `o Dlnitd, O`hmntk`h Ilmufq

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    A`hntdnh Ilm`ux

    Nmrknh J`hlv

    Onjrkfl Mnjlrtrnhm

    Nhhl A`utli

    Fdrkstli Erkbnnrm

    Fnrclh Fnp`hl

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    Clrfk! Mnhel! ]dnhe [`u!

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    Clrfk! Mnhel! ]dnhe [`u!

    ]dl Inj

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