Apoptosis, Differentiation, Proliferation, Infammatory Responses

NeuronalPolarity

Apoptosis

InsulinResistance

Apoptosis

InflammatoryResponse

NNeueurroonnalalPolarityPolarity

InflammatoInflammatorryy

AAppoopptositosiss

MAPKKKs

JNK1/2/3

TRADDD

TRAF2

MKPs

Ask1

TAK1

RIP

JNKJJJNK

HPK

TAU

IRS-1

Bad

Itch

Bim

MKK4/7

POSH

MLKs

JIP

c-Jun AFT-2 ELK-1 p53 NFAT STAT3

GrowthFactors Cytokines

PP P P

PP

PP

PP

P

PP

P

P

P

P

P

P

P

P

P

P

P

P

P

P

MEKK1/3DLKMLKsTPL-2

{ Cytokine ReceptorPPPP

PP

PPPPP

RKTS

Btk

Key

Kinase

Phosphatase

TranscriptionFactor

Ligand

MAPK-JNK pathway

Copyright © 2013 Abcam. All Rights Reserved.Discover more at abcam.com/mapk-jnk

Copyright © 2013 Abcam. All Rights Reserved.Discover more at abcam.com/mapk-jnk

Reagent Product code

Low Fluorescence Western Membrane (PVDF) ab133411Optiblot Blue - single step Coomassie-based gel stain ab119211Optiblot Bradford Reagent ab119216Optiblot ECL Detect Kit (23pg-187ng) ab133406Prism Ultra Protein Ladder (10-245 kDa) ab116028Molecular Weight Marker (8.5-70 kDa) ab48854

Optiblot electrophoresis reagents

Related ELISA kitsELISA kit Tests Species reactivity Product code

JNK (Thr183/Tyr185) In-Cell ELISA Kit 1 x 96 well plate Hu, Ms, Rt ab126424PhosphoTracer BAD pSer112 + Total ELISA Kit 1 x 96 well plate Hu, Ms ab119655PhosphoTracer JNK 1/2/3 (pT183/Y185) ELISA kit 1 x 96 well plate Hu, Ms ab119634STAT3 (pY705) + total STAT3 ELISA Kit 1 x 96 well plate Hu, Ms, Rt ab126459

Immunohistochemical staining of paraffin-embedded human lymphoma using ab32445 at 1/100 dilution.

Bad antibody [Y208] (ab32445)5 star reviews: Good

Bad promotes cell death. It successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. It can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (by similarity). Additionally, it appears to act as a link between growth factor receptor signaling and the apoptotic pathways.

ClonalityMApplicationFlow Cyt, ICC/IF, IHC-P, IP, WBHostRbSpecies reactivityHu, Ms, Rt

Antibodies Clonality Application Host Species reactivity Product code

ASK1 antibody [EP553Y] M Flow Cyt, ICC/IF, IHC-P, WB Rb Hu, Ms ab45178Bim antibody [Y36] M ICC/IF, IHC-P, IP, WB Rb Hu ab32158DLK antibody [EPR3486(2)] M ICC/IF, WB Rb Hu, Ms, Rt ab110636ELK1 antibody [E277] M ChIP, ICC/IF, IHC-P, IP, WB Rb Hu, Ms, Rt ab32106IRS1 antibody [EP263Y] M ICC/IF, IHC-P, IP, WB Rb Hu ab40777ITCH/AIP4 antibody [EPR4937] M IHC-P, WB Rb Hu, Ms, Rt ab109018JNK1 antibody [EPR140(2)] M WB Rb Hu, Ms, Rt ab110724JNK1 + JNK2 + JNK3 (phospho T183+T183+T221) antibody [EPR5693] M ICC/IF, IHC-P, IP, WB Rb Hu, Ms, Rt ab124956

JNK1 + JNK2 + JNK3 (phospho Y185 + Y185 + Y223) antibody [EP1597Y] M IP, WB Rb Hu, Ms, Rt ab76572

JNK2 antibody [EP1595Y] M Flow Cyt, ICC/IF, IHC-P, IP, WB Rb Hu, Ms, Rt ab76125JNK3 (MAPK10) antibody [EPR5493(2)] M WB, Flow Cyt, ICC/IF Rb Hu, Ms, Rt ab126591MAP3K8 antibody [EP1103Y] M WB Rb Hu ab52613MEKK3 antibody [EP599Y] M Flow Cyt, ICC/IF, IHC-P, IP, WB Rb Hu, Ms, Rt ab40750MEK4 antibody [EP559Y] M ICC/IF, IHC-P, IP, WB Rb Hu ab33904MEK7 antibody [EP1455Y] M Flow Cyt, ICC/IF, IHC-P, IP, WB Rb Hu, Ms, Rt ab52618MLK3 antibody [EP1460Y] - Carboxyterminal end M Flow Cyt, ICC/IF, WB Rb Hu, Ms ab51068TAK1 antibody [EPR5984] M ICC/IF, IHC-P, WB Rb Hu, Ms, Rt ab109526Tau antibody [EP2456Y] M Flow Cyt, ICC/IF, WB Rb Hu, Ms, Rt ab76128Tau (phospho S198) antibody [EPR2400] M ICC/IF, IHC-P, IP, WB Rb Hu ab79540Tau (phospho S202) antibody [EPR2402] M IP, WB Rb Hu, Ms, Rt ab108387Tau (phospho S404) antibody [EPR2605] M IHC-P, WB Rb Hu, Ms, Rt ab92676Tau (phospho T231) antibody [EPR2488] M IP, WB Rb Hu, Ms, Rt ab151559TRADD antibody [EPR3604] M ICC/IF, IHC-P, IP, WB Rb Hu, Ms, Rt ab110644TRAF2 antibody [EPR6048] M Flow Cyt, ICC/IF, IHC-P, IP, WB Rb Hu, Ms, Rt ab126758

Related antibodies

Key: Hu - Human, Ms - Mouse, Rb - Rabbit, Rt - Rat

- Rabbit Monoclonal Antibodies (RabMAbs)

EX

T_005_13

Product

highlights

MAPK-JNK pathway