Lydic CV 20Feb12

Ralph Lydic, Ph.D. Bert La Du Professor of Anesthesiology

Department of Anesthesiology The University of Michigan 7433 Medical Sciences I

1150 West Medical Center Drive Ann Arbor, MI 48109-5616

(734) 647-7831 [email protected]

EDUCATION AND TRAINING 1979 Ph.D. Physiology, Texas Tech University School of Medicine Lubbock, Texas Thesis Director: John Orem 1979-81 Research Associate Department of Physiology & Biophysics Harvard Medical School, Boston, MA 1981-1984 National Research Service Award Laboratory of Neurophysiology Harvard Medical School, Boston, MA Postdoctoral Mentors: Allan Hobson & R.W. McCarley ACADEMIC APPOINTMENTS 1984-1986 Assistant Professor Physiology & Biophysics and Psychiatry Harvard Medical School, Boston, MA 1986-1989 Associate Professor Medicine and Physiology The Pennsylvania State University College of Medicine Hershey, PA 1989-1991 Associate Professor Anesthesia; Cell and Molecular Physiology Director, Division of Anesthesia and Neuroscience Research The Pennsylvania State University College of Medicine Hershey, PA 1991-1999 Professor Anesthesia; Cell and Molecular Physiology Director, Division of Anesthesia and Neuroscience Research The Pennsylvania State University College of Medicine Hershey, PA

Ralph Lydic

1999-2011 Bert La Du Professor of Anesthesiology and Professor of Physiology Associate Chair for Anesthesiology Research The University of Michigan Ann Arbor, MI 2011- Bert La Du Professor of Anesthesiology and Professor of Physiology Director of Basic Research The University of Michigan Ann Arbor, MI RESEARCH INTERESTS Neuroscience: neurochemical modulation of sleep, anesthesia, and pain GRANTS Present and Active Lydic, R. (P.I.) Cholinergic mechanisms of breathing during sleep. Heart, Lung, and Blood Institute of N.I.H. (R01 HL-40881). Competing Renewal Application to be reviewed in February 2012 Mashour, G.A. (P.I.) and Lydic, R. (Co-I) Frontoparietal mechanisms of anesthetic-induced unconsciousness. (R01 RGM098578A). Competing Renewal Application scored in 4th percentile 2 February 2012. Lydic, R. (P.I.) Cholinergic phenotype in murine models of sleep. Heart, Lung, and Blood Institutes of N.I.H. (R01 HL-065272). Competing Renewal Application funded 01 July 2010 through 30 June, 2014. Award total $1,389,268. Previous Grants Lydic, R. (P.I.) Cholinergic mechanisms of breathing during sleep. Heart, Lung, and Blood Institute of N.I.H. (R01 HL-40881). Competing Renewal Application funded 01 December 2006 through 31 December, 2011. Award total $1,880,086. Lydic, R. (P.I.) Cholinergic mechanisms of breathing during sleep. Heart, Lung, and Blood Institute of N.I.H. (R01 HL-40881; 01-03). 1 July 1989 through June, 1992. Direct cost amount approved before N.I.H. financial adjustments: $334,453.00 Keifer, J. C. (P.I.), Lydic, R. (Research Mentor) Parker B. Frances Fellowship Program. Foundation for Anesthesia Education and Research. Young Investigator Award (J. C. Keifer) September 1991 to 31 August 1992: $66,000. Lydic, R. (P.I.) Small Instrumentation Grant Program. Heart, Lung, and Blood Institute of N.I.H. (1-S15-HL-47749). $13,641 for CCD Imaging System. Lydic, R. (P.I.) Cholinergic mechanisms of breathing during sleep. Heart, Lung, and Blood Institute of N.I.H. (R01 HL-40881; 04-07). Competing Renewal Application,

Ralph Lydic

Funded, July 1992 through April, 1996. Direct cost amount approved before Congressionally directed financial adjustments: $583,000. Lydic, R. (P.I.) Cholinergic mechanisms of breathing during sleep. Heart, Lung, and Blood Institute of N.I.H. (R01 HL-40881; 08-11). Competing Renewal Application, Funded 1 April 1996 through 30 April 2000. Direct cost amount approved before Congressionally directed financial adjustments: $835,651. Lydic, R. (P.I.) Opioid-induced REM sleep inhibition. Heart, Lung, and Blood Institute of N.I.H. (R01 HL-57120). Funded 1 August 1997 through 2001. Direct cost amount approved before Congressionally directed financial adjustments: $704,594. Lydic, R. (Collaborating Investigator); J.K. Shoemaker (P.I.) Dean’s Feasibility Grant 1998-1999: Interstitial Acetylcholine in Human Skeletal Muscle. Division of Cardiology, Department of Medicine, The Pennsylvania State University, College of Medicine. $25,000. Lydic, R. (P.I.) Cholinergic phenotype in murine models of sleep. Heart, Lung, and Blood Institute of N.I.H. (R01 HL-65272). Funded 30 September 1999 through 31 August 2003. Award total $983,480. Lydic, R. (P.I.) Cholinergic mechanisms of breathing during sleep. Heart, Lung, and Blood Institute of N.I.H. (R01 HL-40881). Competing Renewal Application funded 01 April 2000 through 31 March, 2006. Award total $1,468,529. Lydic, R. (P.I.) Opioid-induced REM sleep inhibition. Heart, Lung, and Blood Institute of N.I.H. (R01 HL-57120). Competing Renewal Application funded 1 July 2001 through 30 June 2006. Award total $1,788,265. Lydic, R. (P.I.) Cholinergic phenotype in murine models of sleep. Heart, Lung, and Blood Institute of N.I.H. (R01 HL-65272). Competing Renewal Application funded 1 September 2003 through 31 August 2007. Award total $1,088,558. Lydic, R. (P.I.) Microdialysis delivery of Eszopiclone, Diazepam, and Zolpidem to rat pontine reticular formation effects on acetylcholine release, EEG power, breathing and arousal. November 2007 through November 2008. Sepracor Pharmaceutical. Award Total $158,894. Lydic, R. (P.I.) Sleep: Neurobiology, Medicine and Society. University of Michigan Sleep Class. Education Grant number 31019 from Sanofi-Aventis USA, 4 June 2009 to 9 Sept 2009. Total Award $3,903.

Ralph Lydic

HONORS AND AWARDS 1978-1979 Pre-doctoral Fellowship Award Tarbox Parkinson's Disease Institute Texas Tech University School of Medicine Lubbock, TX 1980 Scholarship Award Neurobiology Program Cold Spring Harbor Laboratory Cold Spring Harbor, NY 1981 Scholarship Award Neurobiology Program Woods Hole Marine Biological Laboratory Woods Hole, MA 1983 Upjohn Pharmaceutical Scholarship Harvard Medical School Boston, MA 1981-1984 National Research Service Award Harvard Medical School Boston, MA 1984-1985 William F. Milton Award Harvard Medical School Boston, MA 1987-1988 Research Initiation Grant The Pennsylvania State University University Park, PA 1990 Research Mentor for: Kirk Gilbert, Ph.D. Scholl Fellowship National Sudden Infant Death Syndrome Foundation 1991 Research Mentor for: Robert Wertz, M.D. Howard E. Morgan Award for Basic Science The Pennsylvania State University College of Medicine Hershey, PA

Ralph Lydic

1991-1992 Research Mentor for: John C. Keifer, M.D. Parker B. Frances Fellowship Young Investigator Award Foundation for Anesthesia Education and Research 1992-1993 Research Mentor for: Kirk Gilbert, Ph.D. Postdoctoral Fellowship National Multisite Training Grant Basic Sleep Research (MH-18825-05) 1993 Mentor for Sarah Wolpert Precollege Science Education Initiative Howard Hughes Medical Institute 1994 Research Mentor for: Lawrence Lee, M.D. Howard E. Morgan Award for Basic Science The Pennsylvania State University College of Medicine Hershey, PA 1994 NASA Visiting Scientist University Space Research Association Johnson Space Center Houston, Texas 1995 Dunaway-Burnham Scholar Department of Physiology Dartmouth Medical School Lebanon, New Hampshire 1996 Thesis Advisor for T.O. Leonard Proctor and Gamble Award American Physiological Society 1996 Mentor for Stacy Davis Precollege Science Education Initiative Howard Hughes Medical Institute 1997 Invited Plenary Speaker The 8th International Rappaport Symposium Zichron Yaacov, Israel 1997 Mentor for Susan Noori Precollege Science Education Initiative Howard Hughes Medical Institute

Ralph Lydic

1998 Research Mentor for: Art Cronin, M.D. Clinical Investigator Award Foundation for Anesthesia Education and Research 1998 Mentor for Daniela Rados College Science Education Initiative Howard Hughes Medical Institute 1998-1999 Julien F. Biebuyck Endowed Professor of Anesthesia The Pennsylvania State University, College of Medicine 1998-2002 Member, NIH Study Section (Respiratory and Applied Physiology) 1999 Mentor for Emily Verner Precollege Science Education Initiative Howard Hughes Medical Institute 1999-2001 President Elect; President, Past President North American Sleep Research Society 1999-current Bert La Du Endowed Professor of Anesthesiology University of Michigan 2003 Academic Achievement Award in Basic Research University of Michigan, Department of Anesthesiology 2005 Invited Faculty 10th Latin-American School of Neuroscience International Brain Research Organization Montevideo, Uruguay 2006- Deputy Editor of the journal Sleep 2007-2010 Invited: Member of Advisory Council

University of Michgan Chapter, National Science Honor Society, Sigma Xi

2008 Invited Discussant: Sepracor Research Forum Salt Lake City, Utah

2009-2014 Co-Director, University of Michigan Comprehensive

Academic Programs of Distinction, American Academy of Sleep Medicine

Ralph Lydic

MEMBERSHIPS IN PROFESSIONAL SOCIETIES 1973- Psi Chi 1976- Society for Neuroscience 1977- Sigma Xi 1978- Sleep Research Society 1980- American Physiological Society 1987- New York Academy of Science 1990- The American Society of Anesthesiologists

1994- Association of University Anesthesiologists 1999- Michigan Society of Anesthesiologists PROFESSIONAL COMMITTEES 1981- National Science Foundation: Ad Hoc Reviewer

1986-1989 American Physiological Society Chairman, Nervous System Steering Committee 1986-1992 American Physiological Society Program Advisory Committee 1989-1992 American Physiological Society Nervous System Section Advisory Committee 1989-1992 American Physiological Society Long-Range Planning 1987-1990 Sleep Research Society Executive Committee 1988-1991 Sleep Research Society Publications Chairman and Co-editor Sleep Research Vols. 18-20 1988-91 Association of Professional Sleep Societies Newsletter Editor 1990-92 American Physiological Society Nominating Committee 1990 FASEB 1990 Chairman, Theme Committee Nervous System Function and Disorder, Washington, DC 1991-95 National Sleep Foundation Scientific Advisor Board of Trustees 1992-94 Editor, The Physicians Newsletter National Sleep Foundation 1994-95 Councilor, American Physiological Society Central Nervous System Section 1994-96 American Physiological Society Committee on Committees

Ralph Lydic

1998 Sleep Research Society Vision /2020 Task Force

1997-00 American Physiological Society Public Affairs Committee 1999-00 American Society of Anesthesiologists Futures of Anesthesiology Committee 2003- American Society of Anesthesiologists Task force on fatigue, Committee on Occupational Health 2010-13 Society for Anesthesia and Sleep Medicine Founding Member and Member of the Board TEACHING 1995-1999 Graduate Program in Neuroscience: Respiratory Control,

Circadian Rhythms, Sleep Neurobiology 2002- present Medical Physiology 500 – Circulation section group leader 2002- present Medical Physiology 500 – Respiration section group leader

First Year Medical Physiology: Respiratory Control 1999- present Founder and Co-Director: Neuroscience 520 “Sleep:

Neurobiology, Medicine, and Society”. An 18-week course for seniors and Graduate students at University of Michigan

GRANT REVIEWER FOR: National Heart, Lung, and Blood Institutes Special Emphasis Panel Molecular Biology and Genetics of Sleep and Sleep Disorders National Sleep Foundation National Science Foundation National Institute of Mental Health Israel Science Foundation U.S. ARMY Research Office Expert Panelist: NIH Director’s Pioneer Award (NDPA) EDITORIAL REVIEWER FOR: American Journal of Physiology NeuroReport, Eur Journal Pain Anesthesiology Neuroscience, Anesthesia & Analgesia Brain Research Neuroscience Letters Chemical Neuroanatomy CRC Press Advisory Board Journal of Applied Physiology Sleep Journal of Neuroscience Life Sciences Physiology and Behavior Sleep and Breathing Synapse European Journal Neuroscience Neuroscience Research Journal of Neurochemistry Anesthesia & Analgesia Journal of Pathology

Ralph Lydic

EDITORIAL BOARDS Consulting Editor 2002-2005 Journal of Applied Physiology Editorial Board: 2005-2007 Journal of Applied Physiology Co-Editor: Contemporary Clinical Neuroscience Series, Humana Press: 1999-present Editor for Translational Science: Journal of Critical Care 2004-present Editorial Board: 2005-present Sleep and Breathing Deputy Editor: SLEEP: 2007-present UNIVERSITY COMMITTEE SERVICE 1986-1993 Program Committee, Interdepartmental Program in Neuroscience 1987 Organizer, Neuroscience Colloquium: "Neuroscience of Neuronal Excitability Control" 1989 Advisory Committee, Department of Anesthesia 1987-91 Secretary/Treasurer: Penn State Univ Chapter, Society for

Neuroscience 1987 Candidate Interviewer for Neuroscience Program Admissions 1988-89 Organizer, Pulmonary Medicine Research Conferences 1989 Candidate Interviewer for Medical School Admissions 1990-91 Search Committee: Neuroscience and Anatomy Chair 1990-91 Eric A. Walker Anesthesia Fellowship Review Committee 1990-98 Biological Safety Committee 1991 Research Information Systems Policy Advisory Committee 1991-99 Research Animal Utilization Committee 1992-97 Recombinant DNA Committee 1993-94 Search Committee: Cardiovascular signal transduction faculty 1996-97 Search Committee: Chief Pulmonary Medicine & Intensive Care 1999-01 UM Center for Integrative Genomics, Organizing Committee

2000- UM Anesthesiology Tenure and Promotions Committee

TRAINEES: Graduate Students, Medical Students and Postdoctoral Trainees 1988 E. V. Bonyak, M.D. 1989 R. Wertz, M.D. 1990 J. Veino, M.D. 1990 G. Wickey, M.D. 1988-1992 K. Gilbert, Ph.D. (Neuroscience) 1990-1992 J.C. Keifer, M.D. (Postdoctoral Fellow) 1990-1994 L. Lee, M.D. 1992-1998 T. Leonard, M.D., Ph.D. (Neuroscience) 1992-1995 V. Mallios, Ph.D. (Physiology) 1993 J. Collan, Medical Student, U. Helsinki, Finland 1994-1998 L. Capece, Ph.D. (Neuroscience) 1994 R. Guzman, Medical Student, UNAM, Mexico City 1994 L. Martinez, Medical Student, UNAM, Mexico City 1995 A. Cronin, M.D. (Anesthesia Resident) 1995-96 U. Hoglund, Ph.D., Upsalla, Sweden (Fellow) 1997-98 P. Tenorio, D.V.M., Bogota, Columbia 1997-98 A.K. Kshatri, M.D. (Pain Fellow) 1998-99 S. Mortazavi, M.D. (Anesthesia resident; Pain Fellow) 1999-00 J. McGinley, M.D. (Anesthesiology faculty)

Ralph Lydic

2001 Akiko Kurachi (UM medical student) 2001 Audry Wells (UM medical student) 2001 Cynthia Puro (UM medical student) 2000-01 R. Struthers, M.D. (Anesthesiology faculty) 2001-03 George DeMarco, D.V.M. (Postdoctoral Fellow) 2002-04 Christopher Douglas, Ph.D. (Postdoctoral Fellow) 2003- Ed Kimlin (medical student) 2004 Rebecca Leshan (UM Graduate Student Research Rotation) 2004-08 Crista Van Dort (Ph.D. candidate Cellular & Molecular Physiology) 2003-05 Nadir Osman, M.D. (Postdoctoral Fellow) 2004 Jessica White (medical student) 2004-09 Chris Watson, Ph.D. (Postdoctoral Fellow) 2004-09 Viviane Hambrecht, Ph.D. (Postdoctoral Fellow) 2005-09 Giancarlo Vanini, M.D. (Postdoctoral Fellow) 2006-08 Chad Brummett, M.D., Assist. Prof. Anesthesiology 2006-07 Zhenghong Zhu, M.D., Ph.D. (Postdoctoral Fellow) 2007 Ginger Leonard (UM medical student) 2007-09 Georges Gettys, M.D. (Postdoctoral Fellow) 2007-08 Aaron Muncey (UM medical student) 2007-08 Ariana Nelson (UM medical student) 2008 Ming Zhou (UM medical student) 2009 Allison Janda (UM medical student) 2010 Liz Hong (UM medical student) 2010-11 Chiara Zanette (Univ Milano, Italy, medical student) 2011- Abigail Garrity, Ph.D. student in Neuroscience Ph.D. THESES ROLE: AREA OF STUDY: Y. Zhang member Ph.D., Neuroscience, 1989 B.X. Carlson member Ph.D., Neuroscience, 1992 K. Gilbert Chairman Ph.D., Neuroscience, 1992 J. Nave member Ph.D., Pharmacology, 1993 M. Saulino member M.D., Ph.D., Biological Chemistry, 1993 R. Fay member Ph.D., Neuroscience, 1994 V. Mallios member Ph.D., Physiology, 1995 T.O. Leonard Chairman M.D., Ph.D., Neuroscience, 1996 M.L. Capece Chairman Ph.D., Neuroscience, 1998 Seok-Hyon Jo member Ph.D., Physiology, 1998 H. Montgomery-Downs member Ph.D., Biobehavioral Sciences, 2001 D. Tanase Chairman Ph.D., Neuroscience, 2002 J. Vazquez member Ph.D., Neuroscience, 2002 C. Douglas Chairman Ph.D., Neuroscience, 2002 J. Morrow member Ph.D., Neuroscience, 2003 R. Bernard member Ph.D., Pharmacology, 2006 C. Coleman member Ph.D., Pharmacology 2006 E. Nunamaker member Ph.D., Biomedical Engineering, 2006 M. Johnson member Ph.D., Biomedical Engineering, 2007 B. R. Cais member Ph.D., Mathematics, 2007 J. Perryman member Ph.D. Neuroscience, 2010 Crista Van Dort Chairman Ph.D., Physiology, 2008

Ralph Lydic

RaShonda Flint member Ph.D., Pharmacology, 2010 Holly Brevig member Ph.D., Pharmacology, 2010 Matt Gibson member Ph.D., Biomedical Engineering, current Jennifer Thompson member Ph.D., Pharmacology, current RECENT UNDERGRADUATE TRAINEES (* = earned authorship on abstract or paper): Grant N. Bowman* UM03; Wayne State Medical School class of 2007 Adam Hill* UM 07; Ricardo Garza-Grande* Michigan State Med School, Class 2010 Brian Jespersen* UM07 Eduardo Icaza* UM08; University of Michigan Medical School class of 2012 Amanda Puro* UM08, Michigan State Medical School class of 2012 Heather Bowman* UM08, Wayne State Medical School class of 2012 Honors Thesis in Cell, Molecular, Developmental Biology Fei-Fei Wang* UM08, Harvard Dental School, class of 2012 Honors Thesis in Biological Chemistry Lindsey Bouchard* UM class of 07, McGill Graduate School Eric Skulsky* UM06, University of Michigan Dental School class of 2010 Adam Saulles* UM08, U. Michigan School of Pharmacy class of 2011 Phil Vlisides* UM06, University of Michigan Medical School class of 2010 Honors Thesis in Cell, Molecular, Developmental Biology Ginger Leonard University of Michigan Medical School class of 2010 Ariana Nelson* University of Michigan Medical School class of 2010 Aaron Muncey* University of Michigan Medical School class of 2010 Ming Zhuo* University of Michigan Medical School class of 2011 Alanna Battersby* UM08, Wayne State Medical School class of 2013 Elizabeth Gerow* UM class of 2010 Elizabeth Gauthier* UM class of 2009, Midwestern Med School class 2014 Sarah Guzick* UM class of 2009 Frank Amodeo* UM class of 2009 Allison Janda* Bucknell 2010, UM Medical School class of 2014 Melissa Teran* UM class of 2010 Emily West* UM class of 2009, Columbia Medical School class of 2014 Melinda Mitchell* Class of 2008, Wayne Medical School class of 2015 Kelsie Norton* UM class of 2011 Stephanie Lazar* UM Class of 2011, Wayne Medical School class of 2015 Honors Thesis in Neuroscience Kristi Nemanis* UM Class of 2012 Abram Davidov* UM Class of 2012 Honors Thesis in Neuroscience William Filbey* UM Class of 2012 Michael Sternberg* UM Class of 2011

Ralph Lydic

SELECTED INVITED LECTURES AND SYMPOSIA 1994 NASA, Johnson Space Center Invited Lecture 1994 Robert Wood Johnson Med. Sch. Invited Lecture 1995 Harvard Medical School Invited Lecture 1995 Signal Transduction and Sleep Symposium Chairman 1995 University S. Florida Invited Lecture 1996 NINCD/NASA Workshop Invited Lecture 1996 American Thoracic Society Invited Lecture 1997 8th International Rappaport Symposium, Zichron, Israel Invited Lecture 1999 Sleep and Pain; World Federation Symposium Chairman of Sleep Research Societies, Dresden 1999 Nitric Oxide and Sleep; World Federation of Sleep Research Societies Dresden Symposium Co-Chairman 1999 National Institute on Drug Abuse Invited Lecture 1999 Winter Conf. Brain Research Invited Lecture 1999 Nat. Heart, Lung, Blood, Inst. Invited Lecture 1999 University of Toronto Invited Lecture 2000 Fundacion Jimenez Diaz, Madrid Invited Lecture 2000 Anesthesiology Grand Rounds, Invited Lecture

Duke University 2000 American Society of Panel Chairman

Anesthesiologists 2001 Experimental Biology Symposium Invited Lecture on Upper Airway Control

2001 Journal Sponsored Symposium Invited Lecture American Society of

Anesthesiologists 2002 Howard University Invited Lecture 2002 Northeastern Sleep Society Invited Lecture 2003 Experimental Biology Symposium Invited Lecture on Pontine Modulation of Breathing 2003 Societa’Italiana di Ricerca sul Sonno Invited Lecture 2004 University of Arkansas Invited Lecture 2005 Association of Professional Sleep Societies Trainee Day Workshop Invited Lecture 2006 Association of University Anesthesiologists Moderated Symposium: “Fatigue, Sleep, & Anesthesia” 2006 Canadian Pain Society Invited Lecture 2006 Association of Professional Sleep Societies Trainee Day Workshop Invited Lecture 2006 McGill University Department of Anesthesiology Invited Lecture 2007 Michigan Chapter Am. Assoc. Lab Animal Sci. Invited Lecuture 2008 January 18, Invited lecture: Accademia Pontaniana: Recent

Advances in Sleep and Anesthesia. University of Napoli “Federico II”, ITALY

Ralph Lydic

2008 March 28, Invited Lecture: Department of Cell and Systems Biology, University of Toronto, Toronto, CANADA.

2008 May 23, Invited Lecture: Division of Sleep Medicine, University of Pennsylvania, Visiting Professor lecture on Sleep and Anesthesia

2008 June 10, Invited lecture in “Meet the Professor” Lectures at yearly meeting of the Association of Professional Sleep Societies, Baltimore, MD

2008 July 17, Invited Lecture: Michigan Metabolomics Journal Club 2008 August 10, Invited lecture Monitoring Molecules in Neuroscience:

12th International Conference on In Vivo Methods, 2009 1 March, Invited Lecture, National Sleep Foundation, Washington 2009 7 May, Invited Lecture, American Pain Society, San Diego, CA 2009 14 May, Invited 1st Sino-US Sleep Meeting, China (declined). 2010 14 May, Invited Lecture, Naples Pain Conference, University of

Napoli “Federico II”, ITALY 2010 Invited speaker, Mechanisms Anesthetic Action (MAC 2010),

Toronto, Canada 2011 17 March, Invited Speaker, University of Chicago, Comer Children's

Hospital 2011 Invited speaker, Mechanisms Awareness in Anesthesia (MAA8),

Milwaukee, WI PRO BONO and SCIENCE EDUCATION 1990 Decade of the Brain Testimony to Congressionally Appointed

Panel of the National Institute of Neurological Disorders and Stroke; Hubert H. Humphrey Bldg., Washington, DC

1992 Undergraduate Research Mentor Susan C. Lang, Widener University 1992 Pennsylvania Society for Biomedical Research Reviewer: High School Essay Contest 1992-94 Editor, Physicians Newsletter National Sleep Foundation, Los Angeles, CA 1993 Invited Faculty: UCLA, Lake Arrowhead Conference Center Sleep Neurobiology Training Program 1993-94 Co-organizer: Chem Camp for Kids Department of Anesthesia, Pennsylvania State University College of Medicine, Hershey, PA 1994 Research Project Mentor: Class of Joan Bechtel Hershey Middle School 1995 Co-organizer: Chem Camp for Kids Department of Anesthesia, Pennsylvania State University College of Medicine, Hershey, PA 1996 Workshop for Promoting Sleep and Respiratory Neurobiology Sponsored by American Thoracic Society and National Heart, Lung, and Blood Institute, Bethesda, MD 1998 High School Science Teacher Workshop Pennsylvania Society for Biomedical Research 1997-99 Reviewer for Postdoctoral Grant Applications National Sleep Foundation, Washington, DC 2000 Invited Faculty: UCLA, Lake Arrowhead Conference Center

Ralph Lydic

Sleep Neurobiology Training Program 2000 Mentor for Jahmal Williams

Minority Summer High School Apprentice Program University of Michigan 2002 Invited Faculty: UCLA, Lake Arrowhead Conference Center Sleep Neurobiology Training Program 2003 Invited Lecture, University of Michigan

Undergraduate Research Opportunity Program 2005 Invited Faculty: UCLA, Lake Arrowhead Conference Center Sleep Neurobiology Training Program

Undergraduate Research Opportunity Program 2006- Faculty Mentor: University of Michigan Post-baccalaureate

Research Education Program (PREP) for underrepresented groups. Funded by NIH division of Minority Opportunities in Research.

2008-11 Invited Faculty: UCLA, Lake Arrowhead Conference Center Sleep Neurobiology Training Program (declined)

Ralph Lydic

ADVISORY COMMITTEE SERVICE: 2004- 2006 External Advisory Committee Specialized Neuroscience Program

Howard University, Washington, D.C. 2006- Member: External Advisory Council Sleep Training Program,

Harvard Medical School, Boston, MA

2005- External Advisory Council National Space Biomedical Research Institute NASA, Houston, TX 2009 External Advisory Committee, Case Western Reserve University,

T32 Sleep Training Grant 2011-2016 Chairman, External Advisory Panel, Institute of Circulatory and

Respiratory Health, Canadian Institute of Health Research/Instituts de recherche en santé du Canada

2011-2013 Founding Member Board of Directors, Society for Anesthesia and

Sleep Medicine

CONTINUING EDUCATION: Workshop on Phenotyping New Mouse Models for Heart, Lung, Blood and Sleep Disorders. Jackson Laboratory, Bar Harbor, ME; May 1 to 4, 2002 Reviewed phenotyping protocols used to screen new mouse mutant models for the study of heart, lung, blood and sleep disorders. The course consisted of both didactic and practical hands-on sessions. Workshop on Phenotyping New Mouse Models for Heart, Lung, Blood and Sleep Disorders. Jackson Laboratory, Bar Harbor, ME, May 6-10, 2003 The program focused primarily on blood pressure measurement, ultrasound, EKG and coagulation profiles, and the theory and methods used in the screening of sleep and respiratory mutants. The workshop represents a unique opportunity for trainees to work in small groups behind the animal barrier in the new ENU mutagenesis core facility adjacent to the Applied Genomics Training Center in the Genetic Resources Building at The Jackson Laboratory. Discovery Strategies Conference: Modeling Human Metabolic Syndrome and Type 2 Diabetes in Rodents Jackson Laboratory, Bar Harbor, ME; Aug 5 – 7, 2007 Focused on mouse models www.jax.org/phenome as a tool for describing features of human metabolic syndrome and associated diseases. Monitoring Molecules in Neuroscience 12th International Conference on In Vivo Methods. Vancouver, Canada; August 10-14, 2008. The mission of the conference is to provide a platform to facilitate the development and refinement of methods for the detection of chemicals in the brain. www.invivo2008.com Naples Pain Conference, University of Napoli “Federico II”, ITALY. May 16-19, 2010. An international update on pain mechanisms and therapeutics. http://www.frontiereanestesia.unina.it/congress-main-page

Ralph Lydic

BIBLIOGRAPHY Peer-Reviewed Publications

1. Lydic R. and Anson J. A modified shock-delivery system for quail. Journal of the Experimental Analysis of Behavior 22: 441-443, 1974.

2. Carlson R. and Lydic R. The effects of ethanol upon threshold and response rate for self- stimulation. Psychopharmacology 50: 61-64, 1976.

3. Anderson D. and Lydic R. Ratio data and the quantification of drug effects. Neuroscience and Biobehavioral Reviews 1: 55-57, 1977.

4. Lydic R, Britton S, Davies D, Lutherer L, and Anderson D. An interactive program on the PDP-11 for computing organ blood flow from data obtained using the radioactive microsphere technique. Computer Programs in Biomedicine 7: 287-292, 1977.

5. Anderson D and Lydic R. On the effects of using ratios in the analysis of variance. Neuroscience and Biobehavioral Reviews 1: 225-229, 1977.

6. Anderson D and Lydic R. A simulation program examining the use of ratios as raw variables in analyses of variance. Computer Programs in Biomedicine 8:87-90, 1978.

7. Orem J, Norris P, and Lydic R. Laryngeal abductor activity during sleep. Chest 73: 300-301, 1978.

8. Orem J and Lydic R. Upper airway function during sleep and wakefulness: Experimental studies on normal and anesthetized cats. Sleep 1: 49-68, 1978.

9. Orem J, Lydic R, and Norris P. Experimental control of the diaphragm and laryngeal abductor muscles by brain stem arousal systems. Respiration Physiology 38: 203-221, 1979.

10. Lydic R and Orem J. Respiratory neurons of the pneumotaxic center during sleep and wakefulness. Neuroscience Letters 15: 187-192, 1979.

11. Lydic R and Moore-Ede M. Three dimensional structure of the suprachiasmatic nuclei in the diurnal squirrel monkey (Saimiri Sciureus). Neuroscience Letters 17: 295-299, 1980.

12. Lydic R, Schoene WC, Czeisler C, and Moore-Ede M. Suprachiasmatic region of the human hypothalamus: Homolog to the primate circadian pacemaker? Sleep 2: 355-361, 1980.

13. Fuller C, Lydic R, Sulzman F, Albers E, Tepper B and Moore-Ede M. Circadian rhythm of body temperature persists after suprachiasmatic lesions in the squirrel monkey. American Journal of Physiology 241: R385-R391, 1981.

Ralph Lydic

14. Albers E, Lydic R, Gander, P and Moore-Ede M. Gradual decay of circadian drinking organization following lesions of the suprachiasmatic nuclei in primates. Neuroscience Letters 27:119-124, 1981.

15. Albers E, Lydic R and Moore-Ede M. Entrainment and masking of circadian drinking rhythms in primates: Influence of light intensity. Physiology and Behavior 28: 205-211, 1982.

16. Lydic R, Albers E, Tepper B, and Moore-Ede M. Three-dimensional structure of the mammalian suprachiasmatic nuclei: A comparative study of five species. Journal of Comparative Neurology 204: 225-237, 1982.

17. Fuller CA, Lydic R, Sulzman F, Albers H, Tepper B, and Moore-Ede M. Auditory entrainment of primate drinking rhythms following partial suprachiasmatic nuclei lesions. Physiology and Behavior 31: 573-576, 1983.

18. Lydic R, McCarley RW, and Hobson JA. Enhancement of dorsal raphe discharge by medial pontine reticular formation stimulation depends on behavioral state. Neuroscience Letters 38: 35-40, 1983.

19. Lydic R, McCarley RW, and Hobson JA. The time-course of dorsal raphe discharge, PGO-waves and muscle tone averaged across multiple sleep cycles. Brain Research 274: 365-370, 1983.

20. Albers E, Lydic R, Gander P, and Moore-Ede M. Role of the suprachiasmatic nuclei in the circadian timing system of the squirrel monkey. I: The generation of rhythmicity. Brain Research 300: 275-284, 1984.

21. Albers E, Lydic, R and Moore-Ede M. Role of the suprachiasmatic nuclei in the circadian timing system of the squirrel monkey. II: Light-dark cycle entrainment. Brain Research 300: 285-293, 1984.

22. Stopa EG, King JC, Lydic R and Schoene, WC. Human brain contains vasopressin and vasoactive intestinal polypeptide neuronal subpopulations in the suprachiasmatic region. Brain Research 297: 159-163, 1984.

23. Lydic R, McCarley RW, and Hobson JA. Forced activity alters sleep cycle periodicity and dorsal raphe discharge rhythm. American Journal of Physiology 247: R135-R145, 1984.

24. Gander P, Lydic R, Albers H and Moore-Ede M. Forced internal desynchronization between circadian temperature and activity rhythms in squirrel monkeys. American Journal of Physiology 248:R567-R572, 1985.

25. Lydic R, McCarley RW, and Hobson JA. Timing function of the dorsal raphe nucleus and the temporal organization of the ultradian sleep cycle. Experimental Brain Research Suppl. 12:125-144, 1985.

26. Hobson JA, Lydic R and Baghdoyan HA. Evolving concepts of sleep cycle generation: From brain centers to neuronal populations. The Behavioral and Brain Sciences 9:371-400, 1986.

Ralph Lydic

27. Hobson JA, Lydic R, and Baghdoyan HA. When is a reflex not a reflex? The riddle of behavioral state control. The Behavioral and Brain Sciences 9:426-448, 1986.

28. Callaway CW, Lydic R, Baghdoyan HA, and Hobson JA. Pontogeniculo-occipital waves: Spontaneous visual system activity during rapid eye movement sleep. Cellular and Molecular Neurobiology 7:105-149, 1987.

29. Lydic R. State-dependent aspects of regulatory physiology. The FASEB Journal 1: 6-15, 1987.

30. Schwartz WJ, Lydic, R and Moore-Ede M. In vivo metabolic activity of the suprachiasmatic nuclei: Non-uniform intranuclear distribution of 14 C-labeled deoxyglucose uptake. Brain Research 424: 249-257, 1987.

31. Lydic R, McCarley RW, and Hobson JA. Serotonin neurons and sleep: I. Long-term recordings of dorsal raphe discharge frequency and PGO waves. Archives Italiennes de Biologie 125:317-343, 1987.

32. Lydic R., McCarley RW, and Hobson JA. Serotonin neurons and sleep: II. Time course of dorsal raphe discharge, PGO waves, and behavioral states. Archives Italiennes de Biologie 126:1-28, 1987.

33. Baghdoyan HA, Lydic, R, Callaway C, and Hobson JA. Increased ponto-geniculo-occipital (PGO) wave frequency following central administration of neostigmine. Neuroscience Letters 82:278-284, 1987.

34. Lydic R. The central regulation of sleep and autonomic physiology. In: The Clinical Physiology of Sleep. Bethesda: The American Physiological Society, 1988, pgs. 1-20.

35. Lydic R, Wiegand L, and Wiegand D. Sleep-dependent changes in upper airway muscle function. In: The Clinical Physiology of Sleep. Bethesda: The American Physiological Society, 1988, pgs. 97-124.

36. Baghdoyan HA, Lydic, R, Callaway CW, and Hobson JA. The carbachol-induced enhancement of desynchronized sleep signs is dose dependent and antagonized by centrally administered atropine. Neuropsychopharmacology 2: 67-79, 1989.

37. Lydic R, Baghdoyan HA, and Zwillich CW. State-dependent hypotonia in posterior cricoarytenoid muscles of the larynx caused by cholinoceptive reticular mechanisms. The FASEB Journal 3:1625-1631, 1989.

38. Lydic R. and Baghdoyan HA. Cholinoceptive pontine reticular mechanisms cause state-dependent respiratory changes in the cat. Neuroscience Letters 102: 211-216, 1989.

39. Lydic R. Central pattern-generating neurons and the search for general principles. The FASEB Journal 3: 2457-2468, 1989.

Ralph Lydic

40. Gilbert K., and Lydic R. Parabrachial neuron discharge in the cat is altered during the carbachol-induced REM sleep-like state (DCarb). Neuroscience Letters 120:241-244, 1990.

41. Lydic R, Baghdoyan HA, Hibbard L, Bonyak EV, DeJoseph MR, and Hawkins R. Regional brain glucose metabolism is altered during rapid eye movement sleep in the cat: a preliminary study. Journal of Comparative Neurology. 304: 517-529, 1991.

42. Lydic R, Baghdoyan HA, Wertz R, and White DP. Cholinergic reticular mechanisms influence state-dependent ventilatory response to hypercapnia. American Journal of Physiology. 261:R738-R746, 1991.

43. Lorinc Z, Derr J, Snider M and Lydic R. Defining origin of positive slope in hypercapnic ventilatory response curve. American Journal of Physiology. 261:R747-R751, 1991.

44. Lydic R, Baghdoyan HA and Lorinc Z. Microdialysis of cat pons reveals enhanced acetylcholine release during state-dependent respiratory depression. American Journal of Physiology. 261:R766-R770, 1991.

45. Lydic R and Baghdoyan HA. Cholinergic pontine mechanisms causing state-dependent respiratory depression. News in Physiological Sciences 7: 220-224, 1992.

46. Keifer JC, Baghdoyan HA and Lydic R. Sleep disruption and increased apneas after pontine microinjection of morphine. Anesthesiology 77: 973-982, 1992.

47. Lydic, R. and H.A. Baghdoyan. Pedunculopontine stimulation alters respiration and increases ACh release in the pontine reticular formation. American Journal of Physiology 264: R544-R554, 1993.

48. Gilbert, K. and R. Lydic. Muscarinic cholinoceptive reticular mechanisms and parabrachial neuron discharge: A novel experimental approach. NeuroReport 4: 271-274, 1993.

49. Lydic, R., J.C. Keifer, H.A. Baghdoyan, and L. Becker. Microdialysis of the pontine reticular formation reveals inhibition of acetylcholine release by morphine. Anesthesiology 79: 1003-1012, 1993.

50. Fay, R., K. Gilbert, and R. Lydic. Pontomedullary neurons transsynaptically labeled by laryngeal pseudorabies virus. NeuroReport 5: 141-144, 1993.

51. Keifer, J.C., H.A. Baghdoyan, L. Becker, and R. Lydic. Halothane anesthesia causes decreases pontine acetylcholine release and increases EEG spindles. NeuroReport 5: 577-580, 1994.

52. Gilbert, K. and R. Lydic. Pontine cholinergic mechanisms cause state-dependent changes in the discharge of parabrachial neurons. American Journal of Physiology 266: R136-R150, 1994.

Ralph Lydic

53. Lydic, R. Cholinergic control of sleep and breathing. In: Microgravity Environment Related to Cardiovascular, Pulmonary, and Blood Functions and Diseases. NHLBI/NASA Workshop Report, pp. 59-63, 1994.

54. Lee, L.H., D.B. Friedman, and R. Lydic. Respiratory nuclei share synaptic connectivity with pontine reticular regions regulating REM sleep. American Journal of Physiology 268: L251-L262, 1995.

55. Cronin, A., J.C. Keifer, H.A. Baghdoyan, and R. Lydic. Opioid inhibition of rapid eye movement sleep by a specific mu receptor agonist. British Journal of Anaesthesia 74: 188-192, 1995.

56. Mallios, V.J., R. Lydic and H.A. Baghdoyan. Muscarinic receptor subtypes are differentially distributed across brain stem respiratory nuclei. American Journal of Physiology 268: L941-L949, 1995.

57. Shuman, S., L. Capece, H.A. Baghdoyan, and R. Lydic. Pertussis toxin-sensitive G proteins mediate carbachol-induced REM sleep and respiratory depression. American Journal of Physiology 269: R308-R317, 1995.

58. Leonard, T.O. and R. Lydic. Nitric oxide synthase inhibition decreases pontine acetylcholine release. Neuroreport 6: 1525-1529, 1995.

59. Fitzgerald, R.S., M. Shirahata, T. Ide, and R. Lydic. The cholinergic hypothesis revisited-An unfinished story. Biological Signals 4: 298-303, 1995.

60. Keifer, J.C., H.A. Baghdoyan and R. Lydic. Pontine cholinergic mechanisms modulate the cortical electroencephalographic spindles of halothane anesthesia. Anesthesiology 84: 945-954, 1996.

61. Lydic, R. Reticular modulation of breathing during sleep and anesthesia. Current Opinion in Pulmonary Medicine 2: 474-481, 1996.

62. Roth, M.T., M.A. Fleegal, R. Lydic, and H.A. Baghdoyan. Pontine acetylcholine release is regulated by muscarinic autoreceptors. Neuroreport 7: 3069-3072, 1996.

63. Leonard, T.O. and R. Lydic. Pontine nitric oxide modulates acetylcholine release, rapid eye movement sleep generation, and respiratory rate. Journal of Neuroscience 17: 774-785, 1997.

64. Capece, M.L., S.M.N. Efange, and R. Lydic. Vesicular acetylcholine transport inhibitor suppresses REM sleep. Neuroreport 8: 481-484, 1997.

65. Capece M.L. and R. Lydic. cAMP and protein kinase A modulate cholinergic rapid eye movement sleep generation. American Journal of Physiology 273: R1430-R1440, 1997.

66. Baghdoyan, H.A., R. Lydic, and M.A. Fleegal. M2 muscarinic autoreceptors modulate acetylcholine release in the pontine reticular formation. Journal of Pharmacology and Experimental Therapeutics 286: 1446-1452, 1998.

Ralph Lydic

67. Kshatri, A.M., H.A. Baghdoyan and R. Lydic. Cholinomimetics, but not morphine, increase antinociceptive behavior from pontine reticular regions regulating rapid eye movement sleep. Sleep 21: 677-685, 1998.

68. Capece, M.L., H.A. Baghdoyan and R. Lydic. Carbachol-stimulates [35S]guanylyl 5’-(g amma-thio)triphosphate binding in rapid eye movement sleep-related brain stem nuclei of rat. Journal of Neuroscience 18: 3779-3785, 1998.

69. Capece, M.L., H.A. Baghdoyan, and R. Lydic. Opioids activate G proteins in REM sleep-related brain stem nuclei of rat. Neuroreport 9: 3025-3028, 1998.

70. Mortazavi, S., J. Thompson, H.A. Baghdoyan, and R. Lydic. Fentanyl and morphine, but not remifentanil, inhibit acetylcholine release in pontine regions modulating arousal. Anesthesiology 90: 1070-1077, 1999.

71. Baghdoyan, H.A. and R. Lydic. M2 muscarinic receptor subtype in the feline medial pontine reticular formation modulates the amount of rapid eye movement sleep. Sleep 22: 835-847, 1999.

72. Lydic, R. and H.A. Baghdoyan. Koch’s postulates confirm cholinergic modulation of REM sleep. Behavioral and Brain Sciences 23: 966, 2000.

73. Tanase, D., W. Martin, H.A. Baghdoyan, and R. Lydic. G protein activation in rat ponto-mesencephalic nuclei is enhanced by combined treatment with a mu opioid and an adenosine A1 receptor agonist. Sleep 24: 52-62, 2001.

74. Douglas, C.L., H.A. Baghdoyan, and R. Lydic. M2 Muscarinic autoreceptors modulate acetylcholine release in prefrontal cortex of C57BL/6J mouse. Journal of Pharmacology and Experimental Therapeutics 299: 960-966, 2001.

75. Bernard, R., R. Lydic, and H.A. Baghdoyan. Hypocretin-1 activates G proteins in arousal-related brainstem nuclei of rat. Neuroreport 13: 447-450, 2002.

76. Douglas, C.L., H.A. Baghdoyan, and R. Lydic. Prefrontal cortex acetylcholine release, EEG slow-waves, and spindles are modulated by M2 autoreceptors in C57BL/6J mouse. Journal of Neurophysiology 87: 2817-2822, 2002.

77. Vazquez, J., R. Lydic, and H.A. Baghdoyan. The nitric oxide synthase inhibitor NG-nitro-L-arginine increases basal forebrain acetylcholine release during sleep and wakefulness. Journal of Neuroscience 22: 5597-5605, 2002.

78. Lydic, R. and H.A. Baghdoyan. Ketamine and MK-801 decrease ACh release in the pontine reticular formation, slow breathing, and disrupt sleep. Sleep 25: 617-622, 2002.

79. Tanase, D., H.A. Baghdoyan, and R. Lydic. Microinjection of an adenosine A1 agonist into the medial pontine reticular formation increases tail flick latency to thermal stimulation. Anesthesiology 97: 1597-1601, 2002.

Ralph Lydic

80. Douglas, C.L., H.A. Baghdoyan, and R. Lydic. Postsynaptic muscarinic M1 receptors activate prefrontal cortical EEG of C57BL/6J mouse. Journal of Neurophysiology 88: 3003-3009, 2002.

81. Lydic, R., C.L. Douglas, and H.A. Baghdoyan. Microinjection of neostigmine into the pontine reticular formation of C57BL/6J mouse enhances rapid eye movement sleep and depresses breathing. Sleep 25: 835-841, 2002.

82. DeMarco, G.J., H.A. Baghdoyan, and R. Lydic. Differential cholinergic activation of G proteins in rat and mouse brainstem: relevance for sleep and nociception. Journal of Comparative Neurology 457: 175-184, 2003.

83. Tanase, D., H.A. Baghdoyan, and R. Lydic. Dialysis delivery of an adenosine A1 receptor agonist to the pontine reticular formation decreases acetylcholine release and increases anesthesia recovery time. Anesthesiology 98: 912-920, 2003.

84. Bernard, R., R. Lydic, and H.A. Baghdoyan. Hypocretin-1 causes G protein activation and increases ACh release in rat pons. European Journal of Neuroscience18:1775-1785, 2003.

85. DeMarco, G.J., H.A. Baghdoyan, and R. Lydic. Carbachol in the pontine reticular formation of C57BL/6J mouse decreases acetylcholine release in prefrontal cortex. Neuroscience 123: 17-29, 2004.

86. Douglas, C.L., G.J. DeMarco, H.A. Baghdoyan, and R. Lydic. Pontine and basal forebrain cholinergic interaction: Implications for sleep and breathing. Respiratory Physiology and Neurobiology 143: 251-262, 2004.

87. Coleman, C.G., R. Lydic, H.A. Baghdoyan. M2 muscarinic receptors in pontine reticular formation of C57BL/6J mouse contribute to REM sleep generation. Neuroscience, 126: 821-830, 2004.

88. Coleman, C.G., R. Lydic, H.A. Baghdoyan. ACh release in the pontine reticular formation of C57BL/6J mouse is modulated by non-M1 muscarinic receptors. Neuroscience. 126: 831-838, 2004.

89. Douglas, C.L., G.N. Bowman, H.A. Baghdoyan, and R. Lydic. C57BL/6J and B6.V LEPOB mice differ in the cholinergic modulation of breathing. Journal of Applied Physiology 98: 918-929, 2005.

90. Osman, N.I., H.A. Baghdoyan, and R. Lydic. Morphine inhibits acetylcholine release in rat prefrontal cortex when delivered systemically or by microdialysis to basal forebrain. Anesthesiology 103: 779-787, 2005.

91. Lydic, R. and H.A. Baghdoyan. Sleep, anesthesiology, and the neurobiology of arousal state control. Anesthesiology 103: 1268-1295, 2005.

92. Coleman, C.G., H.A. Baghdoyan, and R. Lydic. Dialysis delivery of an adenosine A2A agonist into the pontine reticular formation of C57BL/6J mouse

Ralph Lydic

increases pontine acetylcholine release and sleep. Journal of Neurochemistry 96: 1750-1759, 2006.

93. Bernard R, Lydic R, and Baghdoyan HA. Hypocretin (orexin) receptor subtypes differentially enhance acetylcholine release and activate G protein subtypes in rat pontine reticular formation. Journal of Pharmacology and Experimental Therapeutics 317: 163-171, 2006.

94. Lydic R, Garza-Grande R, Struthers R, and Baghdoyan H.A. Nitric oxide in B6 mouse and nitric oxide-sensitive soluble guanylate cyclase in cat modulate acetylcholine release in pontine reticular formation. Journal of Applied Physiology 100: 1666-1673, 2006.

95. Watson CJ, Lydic R, Baghdoyan HA. Sleep and GABA levels in the oral part of rat pontine reticular formation are decreased by local and systemic administration of morphine. Neuroscience 144: 375-386, 2007.

96. Skulsky EM, Osman NI, Baghdoyan HA, Lydic R. Microdialysis delivery of morphine to the hypoglossal nucleus of Wistar rat increases hypoglossal acetylcholine release. Sleep 30:566-573, 2007.

97. Hambrecht VS, Vlisides PE, Row BW, Gozal D, Baghdoyan HA, and Lydic R. Cholinergic and opioid activation of G proteins in rat hippocampus: Modulation by hypoxia. Hippocampus 17: 934-942, 2007.

98. Brummett CM, Norat MA, Palmisano JM, Lydic R. Perineural administration of dexmedetomidine in combination with bupivacaine enhances sensory and motor blockade in sciatic nerve block in rat. Anesthesiology 109: 502-511, 2008.

99. Watson CJ, Soto-Calderon H, Lydic R and Baghdoyan HA. Wakefulness is increased by increasing GABA levels in rat pontine reticular formation: A possible mechanism by which hypocretin-1 promotes arousal. Sleep 31: 453- 464, 2008.

100. Geisser ME, Wang W, Smuck M, Koch LG, Britton SL, and Lydic R. Nociception before and after exercise in rats bred for high and low aerobic capacity. Neuroscience Letters 443: 37-40, 2008.

101. Vanini G, Watson CJ, Lydic R, Baghdoyan HA. GABAergic neurotransmission in the pontine reticular formation modulates hypnosis, immobility, and breathing during isoflurane anesthesia. Anesthesiology 109: 978-988, 2008. *Selected for Editorial Focus.

102. Zhu, Z., Bowman, HR, Baghdoyan HA, Lydic R. Morphine increases acetylcholine release in the trigeminal nuclear complex. Sleep 31: 1629-1637, 2008.

103. Hambrecht VS, Vlisides PE, Row BW, Gozal D, Baghdoyan HA, and Lydic R. G proteins in the prefrontal Cortex (PFC) of Sprague-Dawley rat are differentially activated as a function of oxygen status and PFC region. Journal of Chemical Neuroanatomy 37: 112-117, 2009.

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104. Van Dort CJ, Baghdoyan HA, and Lydic R. Adenosine A1 and A2A receptors in the prefrontal cortex modulate acetylcholine release and behavioral arousal. Journal of Neuroscience 29: 871-881, 2009.

105. Wang WW, Baghdoyan HA, Lydic R. Leptin replacement restores supraspinal cholinergic antinociception in leptin-deficient obese mice. Journal of Pain 10: 836-843, 2009

106. Icaza EE, Huang X, Fu Y, Neubig RR, Baghdoyan HA, Lydic R. Isoflurane-induced changes in righting response and breathing are modulated by RGS proteins. Anesthesia and Analgesia 109: 1500-1505, 2009

107. Brummett CM, Padda, AK, Amodeo FS, Welch KB, Lydic R. Perineural dexmedetomidine added to ropivacaine causes a dose-dependent increase in the duration of thermal antinociception in sciatic nerve block in rat. Anesthesiology 111: 1111-1119, 2009.

108. Nelson AM, Battersby AS, Baghdoyan HA, Lydic R. Opioid-induced decreases in rat brain adenosine levels are reversed by inhibiting adenosine deaminase. Anesthesiology 111: 1327-1333, 2009. *Selected for Cover feature and Editorial Focus.

109. Watson SL, Watson CJ, Baghdoyan HA, Lydic R. Thermal nociception is decreased by hypocretin-1 and an adenosine A1 receptor agonist microinjected into the pontine reticular formation of Sprague Dawley rat. Journal of Pain 11: 535-544, 2010. PMCID: PMC2879477

110. Hambrecht-Wiedbusch VS, Gauthier EA, Baghdoyan HA, Lydic R. Benzodiazepine receptor agonists cause drug-specific and state-specific alterations in EEG power and acetylcholine release in rat pontine reticular formation. Sleep 33:909-18, 2010. PMCID: PMC2894433. *Selected for Editorial Focus.

111. Brevig HN, Watson CJ, Lydic R, Baghdoyan HA. Hypocretin and GABA interact in the pontine reticular formation to increase wakefulness. Sleep 33: 1285-1293, 2010. PMCID: PMC2941414

112. Brown E, Lydic R, Schiff ND. General anesthesia, sleep, and coma. New England Journal of Medicine 363: 2638-2650, 2010. PMID: 21190458

113. Muncey AR, Saulles AR, Koch LR, Britton SL, Baghdoyan HA, Lydic R. Disrupted sleep and delayed recovery from chronic peripheral neuropathy are distinct phenotypes in rat model of metabolic syndrome. Anesthesiology 113: 1176-1185, 2010. PMCID: PMC2962768

114. Brummett CM, Amodeo FS, Janda AM, Padda AK, Lydic R. Perineural dexmedetomidine provides an increased duration of analgesia to a thermal stimulus when compared to a systemic control in a rat sciatic nerve block. Regional Anesthesia and Pain Medicine 35: 427-431, 2010.

Ralph Lydic

115. Flint R, Chang T, Lydic R, Baghdoyan HA. GABAA receptors in the pontine reticular formation of C57BL/6J mouse modulate neurochemical, electrographic, and behavioral phenotypes of wakefulness. J Neuroscience 30: 12301-12309, 2010. PMCID: PMC2952114

116. Vanini G, Wathen BL, Lydic, R, Baghdoyan HA. Endogenous GABA levels in the pontine reticular formation are greater during wakefulness than during REM sleep. J. Neuroscience 31: 2649-2656, 2011. *(Selected for “This week in the Journal) PMCID: PMC3073841

117. Brummett CM, Hong E, Janda AM, Amodeo FS, Lydic R. Perineural dexmedetomidine added to ropivacaine for sciatic nerve block in rats prolongs the analgesia duration by blocking hyperpolarization-activated cation current. Anesthesiology 115: 836-43, 2011.

118. Gauthier EA, Guzick SE, Brummett CM, Baghdoyan HA, Lydic R. Buprenorphine disrupts sleep and decreases adenosine concentrations in sleep-regulating brain regions of Sprague Dawley rat. Anesthesiology 115: 743-53 2011.

119. Watson CJ, Lydic, R, Baghdoyan HA. Glutamate and GABA in rat pontine reticular formation modulate sleep duration. Journal of Neurochemistry 118: 571-80, 2011.

120. Wathen AB, West ES, Lydic R, Baghdoyan HA. Olanzapine causes a leptin-dependent increase in acetylcholine release in mouse prefrontal cortex. SLEEP (Ms In Press) 2012. http://www.journalsleep.org/AcceptedPapers/SP-313-11.pdf

121. Pal D, Walton M, Lipinski B, Lydic R, Koch LG, Britton SL, Mashour GA. Determination of minimum alveolar concentration for isoflurane and sevoflurane in a rodent model of human metabolic syndrome. Anesth Analg (Ms in Press) 2012.

122. Vanini G, Lydic R, Baghdoyan HA. GABA-to-ACh ratio in basal forebrain and cerebral cortex varies significantly during sleep. Ms under review. 2012

123. Gettys GC, Liu F, Kimlin E, Baghdoyan HA, and Lydic R. Adenosine A1 receptors in mouse pontine reticular formation depress breathing, increase anesthesia recovery time, and decrease acetylcholine release. Ms under review. 2012

Ralph Lydic

Invited Editorials, Videos 1. Lydic R. Neurons and rhythms. BioScience 35:315-316, 1985.

2. Lydic, R. and J.F. Biebuyck. Sleep neurobiology: Relevance for mechanistic studies of anaesthesia. British Journal of Anaesthesia 72: 506-508, 1994.

3. Lydic, R. Pain: A bridge linking anesthesiology and sleep research. Sleep 24: 10-12, 2001.

4. Lydic, R. Fact and fantasy about sleep and anesthesiology. Anesthesiology 97: 1050-1051, 2002.

5. Lydic R. Drug enhancement for the healthy versus therapy for the ill. Anesthesia Patient Safety Foundation Newsletter. 20: 5-6, 2005.

6. Lydic, R. Sleep disruption is related to allelic variation in the ob gene. American Journal of Physiology 290: R892-R893, 2006.

7. Lydic, R. The motor atonia of REM sleep: A critical topics forum. Sleep 31: 1471-1472, 2008.

8. Chung F, Hilman D, Lydic R. Sleep medicine and anesthesia: a new horizon for anesthesiologists. Anesthesiology 114: 1261-1262, 2011.

9. Lichtor J.L. and Lydic R. Volatile anesthesia does not satisfy rapid eye movement sleep debt. Anesthesiology 115: 683-4 2011.

10. Nine E and Lydic R. Video invited by the journal Anesthesiology: Obstructive sleep apnea: from neurochemistry to clinical care. A tale of translational science and a vlog. http://page2anesthesiology.org/2011/obstructive-sleep-apnea-from-neurochemistry-to-clinical-care-a-vlog/ 16 November 2011.

Ralph Lydic

Chapters and Reviews

1. Hughes M and Lydic R. Characteristics of H-1 and H-2 histamine receptors which mediate the chronotropic response of rabbit atrial muscle. In: Monographs of the Physiological Society of Philadelphia: Proceedings of the A.N. Richards Symposium on Histamine Receptors. Ed. by T.O. Yellin, SP Medical and Scientific Books, New York, 143-161, 1977.

2. Lydic, R., and H. A. Baghdoyan. The Neurobiology of REM sleep. In: N. A. Saunders and C. Sullivan Sleep and Breathing. 2nd Edition, Vol. 21 of Lung Biology in Health and Disease. C. Lenfant (Ex. Ed.), New York: Marcel Dekker, pp. 47-78, 1994.

3. Lydic, R. Respiratory modulation by non-respiratory neurons: Localization of function varies with arousal state. In: W. J. Schwartz (Ed) Sleep Science: Integrating Basic Research and Clinical Practice. Monographs in Clinical Neuroscience Vol 15. Bern: Karger, 117-143, 1997.

4. Lydic, R. and H.A. Baghdoyan. Cholinergic contributions to the control of consciousness. In: Anesthesia: Biologic Foundations, Vol. 2: Integrated Systems. T.L. Yaksh, C. Lynch, W.M. Zapol, M. Maze, J.F. Biebuyck, and L.J. Saidman (Eds). New York: Lippencott Raven, pgs. 433-450, 1997.

5. Capece, M.L., H.A. Baghdoyan and R. Lydic. New directions for the study of cholinergic REM sleep generation: Specifying presynaptic and postsynaptic mechanisms. In: REM Sleep. B.N. Mallick and S. Inoué (Eds). London: Narosa Press 123-141, 1999.

6. Leonard, T.O. and R. Lydic. Nitric Oxide: A Diffusible Modulator of Physiological Traits and Behavioral States. In: REM Sleep. B.N. Mallick and S. Inoué (Eds). London: Narosa Press 167-193, 1999.

7. Baghdoyan H.A. and R. Lydic. Neurotransmitters and neuromodulators regulating sleep. In: Sleep and Epilepsy: The Clinical Spectrum. C. Bazil, B. Malow, M. Sammaritano, (Eds.), Elsevier Science, Amsterdam, 17-44, 2002.

8. Lydic, R. and H.A. Baghdoyan. Neurochemical Evidence for the Cholinergic Modulation of Sleep and Breathing. In: D. Carley and M. Radulovacki (Eds.), Sleep-Related Breathing Disorders: Experimental Models and Therapeutic Potential. New York, Marcel Dekker, 57-91, 2003.

9. Lydic, R., H.A. Baghdoyan and J. McGinley. Opioids, sedation, and sleep: Different states, similar traits, and the search for common mechanisms. In: Sedation and Analgesia for Diagnostic and Therapeutic Procedures. S. Malviya, N. Naughton, K.K. Tremper (Eds.), Humana Press, New Jersey, 1-32, 2003.

Ralph Lydic

10. Lydic, R. and H. A. Baghdoyan. Sleep and anesthesia. In: Foundations of Anesthesia: Basic and Clinical Sciences, 2nd Edition Edited by H.C. Hemmings and P.M. Hopkins. 361-371, 2005.

11. Bernard, R., R. Lydic, and H.A. Baghdoyan. Hypocretin receptor-activated G proteins revealed by [35S]GTPγS autoradiography. In: The Orexin/Hypocretin System: Physiology and Pathophysiology. Editors: S. Nishino and Takeshi Sakurai. 83-96, 2005.

12. Lydic, R. and H.A. Baghdoyan. Anesthesiology: relevance for sleep medicine. In: Encyclopedia of Sleep Medicine. Edited by T. Lee-Chiong, pages 927-932, 2005.

13. Lydic R and Baghdoyan HA. Neurochemical mechanisms mediating opioid-induced REM sleep disruption. In: Sleep and Pain, edited by G Lavigne, BJ Sessle, M Choinière, and PJ Soja, International Association for the Study of Pain (IASP) Press, Seattle, pp 99-122, 2007.

14. Lydic, R. and Baghdoyan HA. Acetylcholine modulates sleep and wakefulness: A synaptic perspective. In: The Neurochemistry of Sleep and Wakefulness. Edited by J.M. Monti, S.R. Pandi-Perumal, and C.M. Sinton. Cambridge University Press, pgs. 109-143, 2008.

15. Van Dort CJ, Baghdoyan HA, and Lydic R. Neurochemical Modulators of Sleep and Anesthetic States. In: Unconscious Processes. Edited by G.A. Mashour, International Anesthesia Clinics, 46: 75-104, 2008.

16. Gettys GC and Lydic R. Bioenergetics in sleep. In: Encyclopedia of Behavioral Neuroscience. Edited by G. Koob, R.F. Thompson, M. Le Moal. Elsevier, pgs. 153-163, 2010.

17. Vanini G, Baghdoyan HA, Lydic R. Relevance of sleep neurobiology for cognitive neuroscience and anesthesia. In: Consciousness, Awareness, and Anesthesia, Edited by G.A. Mashour, Cambridge University Press, pgs. 1-23, 2010.

18. Watson CJ, Baghdoyan HA, Lydic R. A neurochemical perspective on states of consciousness. In: Suppressing the Mind: Anesthetic Modulation of Memory and Consciousness. Edited by A.G. Hudetz and R.A. Pearce, Springer/Humana Press, pgs. 33-80, 2010.

19. Watson CJ, Baghdoyan HA, Lydic R. Neuropharmacology of sleep and wakefulness. Sleep Medicine Clinics 5: 513-528, 2010

20. Vanini G, Lydic R, Baghdoyan HA. GABAergic modulation of REM sleep. In: Rapid Eye Movement Sleep – Regulation and Function. Edited by Mallick BN, Pandi-Perumal SR, McCarley RW, and Morrison AR. Cambridge University Press; Cambridge, pgs. 206-213, 2011.

21. Watson CJ, Baghdoyan HA, Lydic R. REM sleep regulation by cholinergic neurons: Highlights from 1999 to 2009. In: Rapid Eye Movement Sleep – Regulation and Function. Edited by: Mallick BN, Pandi-Perumal SR, McCarley

Ralph Lydic

RW, and Morrison AR. Cambridge University Press; Cambridge, pgs. 194-205, 2011.

22. Vanini G, P Torterolo, Baghdoyan HA, and Lydic R. The shared circuits of sleep and anesthesia. In Neuroscientific Foundations of Anesthesiology, Oxford University Press, New York, pgs. 33-44, 2011.

23. Baghdoyan HA and Lydic R. The neurochemistry of sleep and wakefulness. In: Basic Neurochemistry 8th Edition. GJ Siegel, RW Albers, DL Price, and (Eds). Elsevier 982-999, 2012.

24. Sternberg M, Baghdoyan HA, and Lydic R. A circular conundrum for pain medicine: Sleep disruption worsens pain and pain medications disrupt sleep. In: Pain Medicine: A Case-Based Approach. CM Brummett and S Cohen (Eds). Oxford University Press, New York, (In Press) 2012.

25. Watson CJ, Baghdoyan HA, and Lydic R. Neuropharmacology of sleep and wakefulness: 2012 Update. In: The Biology of Sleep: best papers from Clinics Series. Edited by Teofilo Lee-Chiong, Elsevier, Philadelphia, PA (In Press) 2012.

Books

1. Lydic R. and Biebuyck JF (Eds.). The Clinical Physiology of Sleep. Bethesda: The American Physiological Society, 1988; 239 pgs.

2. Chase MH, Lydic R and O'Connor C. (Eds.). Sleep Research Vol 18 Los Angeles: The University of California, 1989; 632 pgs.



5. Lydic, R. (Ed.). Molecular Regulation of Arousal States. Cellular and Molecular Neuropharmacology Series. CRC Press, Boca Raton, Fl, 233 pgs. 1997.

6. Lydic, R. and H.A. Baghdoyan (Eds.) Handbook of Behavioral State Control: Cellular and Molecular Mechanisms. CRC Press, Boca Raton, Fl, 700 pgs., 1999.

7. Mashour G.A. and Lydic R. (Eds.) Neuroscientific Foundations of Anesthesiology. Oxford University Press, New York, NY; 2011; 296 pgs.

Ralph Lydic

Book Series Co-Editor Contemporary Clinical Neuroscience Springer Verlag/Humana From 2000 to 2011 the Contemporary Clinical Neurosciences series served to bridge the gap between bench research in the neurosciences and clinical neurology. The series focused on brain and behavior with a special emphasis on the understanding, diseases of the human nervous system. These state-of-the-art research volumes presented an array of preclinical and clinical research programs to a wide spectrum of readers in neuroscience. During the summer of 2011, William Curtis of Springer and the American Physiological Society announced a Clinical Physiology series partnership. Co-editors Ralph Lydic and Helen Baghdoyan viewed Summer 2011 as a natural time to resign editorial roles for the Contemporary Clinical Neurosciences series. • Molecular Mechanisms of Neurodegenerative Disease Marie-Francoise

Chesselet, 2001 • Glutamate and Addiction Barbara Herman, 2002 • Neural Mechanisms of Anesthesia: Joseph Antognini, Earl E. Carstens, and

Douglas Raines, 2002 • Sedation and Analgesia for Diagnostic and Therapeutic Procedures: Shoba

Malviya, Norah N. Naughton, and Kevin Tremper, 2003 • Genetics and Genomics of Neurobehavioral Disorders: Gene S. Fisch, 2003 • The G Protein-Coupled Receptors Handbook: Lakshmi Devi, 2005 • Attention Deficit Hyperactivity Disorder: David Gozal and Dennis Molfese, 2005 • The Orexin/Hypocretin System: Seiji Nishino and Takeshi Sakurai, 2006 • Transgenic and Knockout Models of Neuropsychiatric Disorders: Gene Fisch and

Jonathan Flint, 2006 • Brain Hypoxia and Ischemia: Gabriel Haddad and Shan Ping Yu, 2009 • Oxidative Neural Injury: Sigrid Veasey, 2009 • Thiamine Deficiency and Associated Clinical Disorders: David. W. McCandless,

2009 • Suppressing the Mind: Anesthetic Modulation of Memory and Consciousness:

A.G. Hudetz and R.A. Pearce, 2010 • The Interface of Sleep Medicine and Movement Disorders: Alon Y. Avidan, 2011

Ralph Lydic

ABSTRACTS AND SYMPOSIA A1. Lydic, R. and J. Orem. Reticular influences on laryngeal muscle activity. Sleep

Research 7:34, 1978. A2. Orem, J. and R. Lydic. Control of the respiratory cycle by the midbrain reticular

formation. Neuroscience Abstracts 4:24, 1978. A3. Lydic, R. and J. Orem. Respiratory neurons of the pontine pneumotaxic center.

Neuroscience Abstracts 5:697, 1979. A4. Lydic, R. and J. Orem. Activation of pontine respiratory neurons by stimulation

of the mesencephalic reticular formation. Sleep Research 9:33, 1980. A5. Moore-Ede, M., R. Lydic, C. Czeisler, B. Tepper, and C. Fuller. Characterization

of separate circadian oscillators driving rest-activity and body temperature rhythms. Sleep Research 9:275, 1980.

A6. Lydic, R., E. Albers, B. Tepper, and M. Moore-Ede. Comparative three-

dimensional morphology of the mammalian suprachiasmatic nuclei. Neuroscience Abstracts 6:832, 1980.

A7. Albers, E., R. Lydic, and M. Moore-Ede. Light-dark cycle entrainment of the

persisting circadian rhythm of core body temperature in SCN-lesioned primates. Neuroscience Abstracts 6:708, 1980.

A8. Moore-Ede, M., R. Lydic, C. Czeisler, C. Fuller, and E. Albers. Structure and

function of suprachiasmatic nuclei in human and non-human primates. Neuroscience Abstracts 6:708, 1980.

A9. Schoene, W., R. Lydic, C. Czeisler, and M. Moore-Ede. Does man have a

suprachiasmatic nucleus? Journal of Neuropathology and Experimental Neurology 40:339, 1981.

A10. Albers, E., R. Lydic, P. Gander, and M. Moore-Ede. Role of the suprachiasmatic

nuclei in light-dark cycle entrainment in the squirrel monkey. Sleep Research 10:289, 1981.

A11. Gander, P., R. Lydic, E. Albers, and M. Moore-Ede. The circadian timing system

in squirrel monkeys: Interactions between two putative pacemakers. Sleep Research 10:294, 1981.

A12. Albers, H.E., R. Lydic, P.H. Gander, and M.C. Moore-Ede. Gradual decay of

circadian drinking organization in primates following partial and complete lesions of the suprachiasmatic nuclei. Federation Proceedings 41:1697, 1982.

A13. Lydic, R., R.W. McCarley, and J.A. Hobson. Multiple sleep cycle averaging of

dorsal raphe activity. Sleep Research 11:22, 1982.

Ralph Lydic

A14. Lydic, R., R.W. McCarley, and J.A. Hobson. Discharge characteristics of dorsal raphe neurons during repeated sleep-wake cycles. Neuroscience Abstracts 8:390, 1982.

A15. Lydic, R., R.W. McCarley, and J.A. Hobson. The influence of behavioral activity

on dorsal raphe unit discharge. Sleep Research 12:36, 1983. A16. Lydic, R., R.W. McCarley, and J.A. Hobson. Time-course studies of dorsal

raphe activity during sleep and wakefulness. Sleep Research 12:37, 1983. A17. Lydic, R., R.W. McCarley, and J.A. Hobson. Behavioral modification of dorsal

raphe (DRN) activity, pontogeniculooccipital (PGO) waves and the ultradian sleep cycle. Neuroscience Abstracts 9:1174, 1983.

A18. Lydic, R., R.W. McCarley, and J.A. Hobson. Dorsal raphe discharge is phase-

dependent within sleep states. Sleep Research 13:18, 1984. A19. Lydic, R., R.W. McCarley, and J.A. Hobson. Ponto-Geniculo-Occipital waves:

Parametric studies of their temporal distribution in relation to the sleep cycle and dorsal raphe discharge. Neuroscience Abstracts 10:1170, 1984.

A20. Lydic, R., R.W. McCarley, and J.A. Hobson. Perturbations of sleep cycle period

length produce parallel increases in the frequency of desynchronized (D) sleep and dorsal raphe (DRN) discharge profiles. Neuroscience Abstracts 11:51, 1985.

A21. Baghdoyan, H.A., R. Lydic, C.W. Callaway, and J.A. Hobson. Pontine

microinjection of carbachol produces a dose dependent increase in desynchronized sleep signs. Neuroscience Abstracts 12:899, 1986.

A22. Lydic, R., H.A. Baghdoyan, C.W. Callaway, and J.A. Hobson. Central

administration of neostigmine alters the discharge frequency of ponto-geniculo-occipital waves. Neuroscience Abstracts 12:899, 1986.

A23. Baghdoyan, H.A., R. Lydic, C.W. Callaway and J.A. Hobson. Dose-response

effect of carbachol on desynchronized sleep signs. Neuroscience Letters Suppl. 26:123, 1986.

A24. Lydic, R. Serotonergic and cholinergic influence on posterior cricoarytenoid

muscle function. Neuroscience Abstracts 12:1584, 1987. A25. Baghdoyan, H.A., R. Lydic, C.W. Callaway, and J.A. Hobson. Microinjection of

atropine competitively antagonizes the carbachol induced enhancement of desynchronized sleep signs. Neuroscience Abstracts 13:485, 1987.

A26. Lydic, R., H.A. Baghdoyan, E.V. Bonyak, G. DeJoseph and R.A. Hawkins.

Glucose utilization is increased in pontine nuclei during REM sleep in the cat. The FASEB Journal 2:A1729, 1988.

Ralph Lydic

A27. Lydic, R., H.A. Baghdoyan, K.A. Gilbert and C.W. Zwillich. Cholinergic reticular mechanisms cause state-dependent hypotonia in upper airway muscles. Neuroscience Abstracts 14:625, 1988.

A28. Lydic, R., H.A. Baghdoyan, and C. Gleeson. Cholinoceptive induction of state-

dependent changes in the hypercapnic ventilatory response. The FASEB Journal 3:A404, 1989.

A29. Lydic, R., H.A. Baghdoyan, R. Wertz, and D.P. White. The hypoxic ventilatory

response is altered by cholinoceptive pontine reticular mechanisms. Sleep Res. 18:34, 1989.

A30. Baghdoyan, H.A., R. Lydic, E.V. Bonyak, G. DeJoseph, and R.A. Hawkins.

Rapid eye movement sleep is associated with significant changes in cerebral glucose utilization in specific brain regions. Sleep Res. 18:30, 1989.

A31. Baghdoyan, H.A., R. Lydic, and K.A. Gilbert. Bethanechol microinjected into the

medial pontine reticular formation (mPRF) causes state-dependent changes in respiration. Neuroscience Abstracts 15: 100, 1989.

A32. Lydic, R., H.A. Baghdoyan, and R. Wertz. The cholinoceptive medial pontine

reticular formation (mPRF) mediates state-dependent changes in the ventilatory response to hypercapnia (HCVR) and hypoxia (HVR). Neuroscience Abstracts 15: 100, 1989.

A33. Lorinc, Z., J. Derr, M. Snider, and R. Lydic. Mathematical analysis of

hypercapnic ventilatory response (HCVR) curves. The FASEB Journal 4:A1102, 1990.

A34. Lydic, R. and H.A. Baghdoyan. Respiratory control is altered by cholinergic

pontine reticular mechanisms. The Physiologist 33(4): A-8, 1990. A35. Gilbert, K.A. and R. Lydic. Parabrachial neuron discharge is altered during the

carbachol induced REM sleep-like state. Neuroscience Abstracts 16: 1062, 1990.

A36. Baghdoyan, H.A., R. Lydic, T. Rutherford, and S. Snyder. Simultaneous

forebrain and pontine microinjections of carbachol suppress REM sleep. Neuroscience Abstracts 16, 1056, 1990.

A37. Lydic, R., H.A. Baghdoyan, Z. Lorinc. Microdialysates from the medial pontine

reticular formation (mPRF) reveal increased acetylcholine (ACh) release during the carbachol-induced REM sleep-like state (DCarb). Sleep Research 20:25, 1991.

A38. Keifer, J.C., H.A. Baghdoyan, R. Lydic. Morphine microinjected into the medial

pontine reticular formation (mPRF) decreases REM sleep and increases respiratory apneas. Sleep Research 20:21, 1991.

Ralph Lydic

A39. Gilbert, K. and R. Lydic. Breathing and respiratory neuron discharge during the carbachol-induced REM sleep-like state. Sleep Research 20A:29, 1991.

A40. Lydic, R., H.A. Baghdoyan, Z. Lorinc. Decreased respiratory rate during the

carbachol induced REM sleep-like state (DCarb) is accompanied by increased acetylcholine (ACh) in microdialysates from the medial pontine reticular formation (mPRF). FASEB J. 5: A734, 1991.

A41. Gilbert, K. and R. Lydic. Cholinergic reticular mechanisms produce state-

dependent decreases in parabrachial respiratory neuron discharge. Neuroscience Abstracts 17:620, 1991.

A42. Keifer, J., H.A. Baghdoyan, and R. Lydic. Microinjection of morphine into the

medial pontine reticular formation (mPRF) causes increased number of apneic episodes. Neuroscience Abstracts 17:620, 1991.

A43. Lydic, R., H.A. Baghdoyan and Z. Lorinc. Acetylcholine release in the medial

pontine reticular formation (mPRF) predicts respiratory frequency. Neuroscience Abstracts 17:201, 1991.

A44. Lydic, R., H.A. Baghdoyan and Z. Lorinc. Microdialysis of the medial pontine

reticular formation reveals increased acetylcholine release caused by electrical stimulation of the pedunculopontine tegmental nucleus. Sleep Res. 21: 10, 1992.

A45. Gilbert, K.A. and R. Lydic. Non-M1 cholinergic reticular mechanisms produce a

state-dependent decrease in parabrachial neuron discharge. Neuroscience Abstracts 18: 487, 1992.

A46. Keifer, J.C., H.A. Baghdoyan, and R. Lydic. Acetylcholine release in the medial

pontine reticular formation (mPRF) is inhibited by systemic morphine. Neuroscience Abstracts 18: 253, 1992.

A47. Lee, L.H., J.G. Veino, and R. Lydic. Fluorescent dye tracing reveals reciprocal

connections between respiratory nuclei and the medial pontine reticular formation. Neuroscience Abstracts 18: 124, 1992.

A48. Keifer, J.C., L. Becker, and R. Lydic. Halothane anesthesia diminishes

acetylcholine release in the medial pontine reticular formation. Neuroscience Abstracts 19: 1765, 1993.

A49. Shuman, S.L., H.A. Baghdoyan, and R. Lydic. Manipulation of second

messenger systems in the pontine reticular formation: Effects on sleep and breathing. Neuroscience Abstracts 19: 1403, 1993.

A50. Friedman, D.B., L.H. Lee, and R. Lydic. Projections from raphe to medial

pontine reticular formation and parabrachial nuclei demonstrated by retrograde fluorescent labeling. Neuroscience Abstracts 19: 1403, 1993.

Ralph Lydic

A51. Leonard, T.O., K.A. Gilbert, S.L. Shuman, and R. Lydic. Phasic respiratory events of rapid eye movement sleep are similar during the cholinergically-induced REM sleep-like state. Neuroscience Abstracts 19: 1402, 1993.

A52. Mallios, V.J., J.L. Spotts, R. Lydic, D.C. Mash, and H.A. Baghdoyan.

Quantitative autoradiography of M1, M2, and M3 muscarinic receptor subtypes in respiratory-related nuclei of cat brain stem. Neuroscience Abstracts 19: 749, 1993.

A53. Gilbert, K.A., R. Fay, and R. Lydic. Brainstem pathways to respiratory muscles

of the larynx identified by transneuronal labeling with pseudorabies virus. Neuroscience Abstracts 19: 1402, 1993.

A54. Shuman, S., H.A. Baghdoyan, and R. Lydic. G protein mediation of state-

dependent respiratory depression. American Journal of Respiratory and Critical Care Medicine 149: A308, 1994.

A55. Becker, L., H.A. Baghdoyan, and R. Lydic. Acetylcholine (ACh) release in the

medial pontine reticular formation (mPRF) increases during natural rapid eye movement (REM) sleep. Neuroscience Abstracts 20: 82, 1994.

A56. Cronin, A, J.C. Keifer, H.A. Baghdoyan, and R. Lydic. Mu receptor agonist

microinjected into the medial pontine reticular formation (mPRF) of cat inhibits rapid eye movement (REM) sleep. Neuroscience Abstracts 20: 750, 1994.

A57. Leonard, T.O., L. Becker and R. Lydic. Nitric oxide inhibition causes state-

dependent depression of acetylcholine (ACh) release in the medial pontine reticular formation (mPRF). Neuroscience Abstracts 20: 1590, 1994.

A58. Mallios, V.J., R. Lydic and H.A. Baghdoyan. Respiratory depression during the

bethanechol-induced REM sleep-like state (D-Beth) is not blocked by the M1/M3 muscarinic antagonist 4-DAMP. Neuroscience Abstracts 20: 546, 1994.

A59. Lydic, R., H.A. Baghdoyan, L. Becker, and J.F. Biebuyck. Systemic ketamine

causes dose-dependent alterations in acetylcholine (ACh) release within the medial pontine reticular formation (mPRF). Neuroscience Abstracts 20: 82, 1994.

A60. Leonard, T.O. and R. Lydic. Nitric oxide synthase (NOS) inhibition causes

decreased acetylcholine release from laterodorsal and pedunculopontine tegmental neurons. American Journal of Respiratory and Critical Care Medicine 151: A448, 1995.

A61. Capece, M.L., M.A. Fleegal, H.A. Baghdoyan, and R. Lydic. Transmembrane

signal transduction systems mediating cholinergic REM sleep generation. Neuroscience Abstracts 21: 2068, 1995.

A62. Leonard, T.O. and R. Lydic. Inhibition of nitric oxide synthase in the medial

pontine reticular formation decreases rapid eye movement sleep. FASEB Journal 10: A409, 1996.

Ralph Lydic

A63. Leonard, T.O. and R. Lydic. Nitric oxide synthase inhibition in the medial

pontine reticular formation blocks cholinergic respiratory depression. Abstracts, 8th World Congress on Pain, IASP Press, p. 473, 1996.

A64. Roth, M.T., M.A. Fleegal, R. Lydic, and H.A. Baghdoyan. Muscarinic

autoreceptors modulate acetylcholine (ACh) release in cat medial pontine reticular formation. Neuroscience Abstracts 22: 1988, 1996.

A65. Capece, M.L., M.A. Fleegal, and R. Lydic. Cyclic AMP and protein kinase A in

the pontine reticular formation contribute to cholinergic rapid eye movement sleep generation. Neuroscience Abstracts 22: 374, 1966.

A66. Lydic, R., M.L. Capece, and S.M.N. Efange. Pontine microinjection of 4-

aminobenzovesamicol blocks cholinergic rapid eye movement sleep enhancement. Neuroscience Abstracts 22: 1030, 1996.

A67. Capece, M.L., H.A. Baghdoyan, and R. Lydic. [35S]GTPgS reveals G-protein activation by cholinergic stimulation of brain stem nuclei known to regulate REM sleep. Neuroscience Abstracts 23: 2132 1997.

A68. Kshatri, A.M., H.A. Baghdoyan, M.A. Fleegal and R. Lydic. Supraspinal

cholinergic antinociception evoked from pontine reticular formation regions that regulate REM sleep. Neuroscience Abstracts 23: 2132 1997.

A69. Baghdoyan, H.A., Fleegal, M.A. and R. Lydic. Acetylcholine release in the

medial pontine reticular formation (mPRF) is regulated by M2 muscarinic autoreceptors. Neuroscience Abstracts 23: 2131 1997.

A70. Capece, M.L., H.A. Baghdoyan, and R. Lydic. Opioids induce G protein

activation in REM sleep related brain stem nuclei of rat. Neuroscience Abstracts 24: 694, 1998.

A71. Mortazavi, S. J. Thompson, H.A. Baghdoyan, and R. Lydic. Morphine sulfate

inhibits acetylcholine release in the laterodorsal tegmental nucleus and medial pontine reticular formation. Neuroscience Abstracts 24: 695, 1998.

A72. Lydic, R. M.A. Fleegal, C. Burak, and S. Mortazavi. NMDA channel blockers

applied to the medial pontine reticular formation decrease acetylcholine release, inhibit REM sleep, and depress respiratory rate. Neuroscience Abstracts 24: 695, 1998.

A73. Vazquez, J., N. Parisi, H.A. Baghdoyan, and R. Lydic. Nitric oxide (NO)

synthase and NO-sensitive guanylyl cyclase inhibition differentially modulate ACh release in the forebrain and pons. FASEB Journal 13: A823, 1999.

A74. Martin, W.A., N. Parisi, and R. Lydic. Adenosine modulates cholinergic

activation of G proteins and ACh release in the pontine reticular formation. FASEB J. 13: A823, 1999.

Ralph Lydic

A75. Lydic, R. and N. Parisi. Adenosine and acetylcholine levels in medial pontine reticular formation are decreased by halothane. Neuroscience Abstracts 25: 2145, 1999.

A76 Martin, W.A., D. Tanase, H.A. Baghdoyan, and R. Lydic. Adenosinergic

alteration of opioid-induced G protein activation in sleep-related nuclei. Neuroscience Abstracts 25: 2144, 1999.

A77. Lydic, R., J. Vazquez, N. Parisi, and H.A. Baghdoyan. Nitric oxide (NO) is

directly measurable in acetylcholine releasing regions of the feline medial pontine reticular formation. Sleep Research Online 2 (Supplement 1): 770, 1999.

A78. Douglas, C.L., H.A. Baghdoyan, and R. Lydic. Muscarinic autoreceptors

modulate release of acetylcholine in mouse frontal cortex. Society for Neuroscience Abstracts 26: 1757, 2000.

A79. Tanase, D., D. Hangan, H.A. Baghdoyan, and R. Lydic. Adenosine A1

receptor agonist enhances opioid-induced G protein activation in ponto-mesencephalic nuclei of rat. Society for Neuroscience Abstracts 26: 1757, 2000.

A80. Lydic, R., H.A. Baghdoyan, and J. McGinley. Hypoglossal nucleus acetylcholine

release is decreased by systemically administered morphine. Society for Neuroscience Abstracts 26: 1757, 2000.

A81. Bernard, R., M. Norat, D. Tanase, R. Lydic, and H.A. Baghdoyan. Hypocretin-

1/Orexin-A (hcrt-1/OX-A) activates G proteins in locus coeruleus and pontine reticular nucleus, oral part (PNO). FASEB Journal 15: A231, 2001.

A82. Bernard, R., R. Lydic, and H.A. Baghdoyan. Hypocretin-1/Orexin-A (hcrt-1/OX-A) Induced

G Protein Activation in Rat Locus Coeruleus (LC) Varies as a Function of the 24 hr Light-Dark Cycle. Sleep 24: A136, 2001.

A83. Struthers, R., A. Kurachi, and R. Lydic. Nitric Oxide-Sensitive Soluble Guanylate Cyclase

Modulates Acetylcholine Release in the Medial Pontine Reticular Formation. Sleep 24: A137, 2001.

A84. DeMarco, G.J., H.A. Baghdoyan, M.A. Norat, and R. Lydic. Carbachol Activates G

Proteins in Pontine Reticular Formation of C57BL/6J Mouse. Sleep 24: A140, 2001 A85. Douglas, C.L., H.A. Baghdoyan, and R. Lydic. Muscarinic autoreceptors of the M2

Subtype Modulate Release of Acetylcholine in Mouse Frontal Cortex. Sleep 24: A136, 2001.

A86. Hangan, D., J. Vazquez, H.A. Baghdoyan, and R. Lydic. Nitric Oxide Level in

the Feline Pontine Reticular Formation is Similar during Waking and NREM Sleep and is Decreased by Morphine. Sleep 24: A133, 2001.

Ralph Lydic

A87. Coleman, C.G., C.L. Douglas, H.A. Baghdoyan, and R. Lydic. Muscarinic autoreceptors in mouse oral pontine reticular nucleus (PNO) modulate acetylcholine (ACh) release. Society for Neuroscience Abstracts 27: 1375, 2001.

A88. Douglas, C.L., H.A. Baghdoyan, and R. Lydic. Muscarinic autoreceptors in

mouse frontal cortex are pertussis toxin sensitive. Society for Neuroscience Abstracts 27: 1375, 2001.

A89. Hangan, D., D. Tanase, H.A. Baghdoyan, and R. Lydic. Microdialysis delivery of

an adenosine A1 agonist to feline medial pontine reticular formation (mPRF) decreases acetylcholine (ACh) release and increases recovery time from anesthesia. Society for Neuroscience Abstracts 27: 1375, 2001.

A90. Tanase, D., H.A. Baghdoyan, and R. Lydic. Microinjection of an adenosine A1

agonist into feline medial pontine reticular formation increases tail flick latency to thermal stimulation. Society for Neuroscience Abstracts 27: 1376, 2001.

A91. DeMarco, G.J., H.A. Baghdoyan, M.A. Norat, and R. Lydic. Carbachol activates

G proteins in pontine reticular and periaqueductal gray nuclei of C57BL/6J mouse. Society for Neuroscience Abstracts 27: 1375, 2001.

A92. Vazquez, J., M. Wilcox, R. Lydic, and H.A. Baghdoyan. A nitric oxide synthase

inhibitor increases acetylcholine release in feline basal forebrain. Society for Neuroscience Abstracts 27: 1375, 2001.

A93. Bernard, R., M.A. Norat, R. Lydic, and H.A. Baghdoyan. Hypocretin-1/Orexin-A

differentially activates G proteins in sleep related nuclei of rat brain stem. Society for Neuroscience Abstracts 27: 1375, 2001.

A94. Lydic, R., J. McGinley, H.A. Baghdoyan. Morphine depresses acetylcholine

release in feline hypoglossal (XII) nucleus. Anesthesiology 95: A713, 2001. A95. Bernard, R., G.N. Bowman, M.A. Norat, R. Lydic, and H.A. Baghdoyan. The

hypocretin receptor antagonist SB-334867-A blocks hypocretin-1-induced G protein activation in sleep-related nuclei of rat brain stem. Society for Neuroscience Abstracts 28: 870.4, 2002.

A96. Coleman, C.G., H.A. Baghdoyan, and R. Lydic. Exploring muscarinic receptor

subtype regulation of acetylcholine (ACh) release in mouse pontine reticular nucleus, oral part (PnO). Society for Neuroscience Abstracts 28: 870.5, 2002.

A97. DeMarco, G.J., H.A. Baghdoyan, A. Hill, and R. Lydic. Comparison of

cholinergically activated G proteins in basal forebrain of mouse and rat. Society for Neuroscience Abstracts 28: 870.6, 2002.

A98. Douglas, C.L., H.A. Baghdoyan, and R. Lydic. M2 autoreceptors modulate

prefrontal cortical acetylcholine (ACh) release and M1 heteroreceptors activate cortical EEG in C57BL/6J mouse. Society for Neuroscience Abstracts 28: 870.7, 2002.

Ralph Lydic

A99. Garza-Grande, R., K. Wiesenauer, H.A. Baghdoyan, and R. Lydic. Nitric oxide modulates acetylcholine (ACh) release in pontine reticular formation (PRF) of C57BL/6J mouse. Society for Neuroscience Abstracts 28: 870.8, 2002.

A100. Lydic, R., C.L. Douglas, and H.A. Baghdoyan. Neostigmine microinjected into

pontine reticular formation (PRF) of C57BL/6J mouse causes a rapid eye movement (REM) sleep-like state and disordered breathing. Society for Neuroscience Abstracts 28: 870.10, 2002.

A101. Bernard, R., R. Lydic, and H.A. Baghdoyan. Hypocretin-1 increases

acetylcholine (ACh) release in rat pontine reticular nucleus, oral part (PnO). FASEB Journal 17: 390.6, 2003.

A102. Coleman, C.G., H.A. Baghdoyan, and R. Lydic. M2 and/or M4 muscarinic

receptors in the pontine reticular formation (PRF) modulate PRF acetylcholine (ACh) release and rapid eye movement sleep in C57BL/6J (B6) mouse. FASEB Journal 17: 390.14, 2003.

A103. DeMarco, G.J., H.A. Baghdoyan, A. Hill, and R. Lydic. Carbachol activates

muscarinic cholinergic receptor (mAChR) coupled G proteins and decreases acetylcholine (ACh) release in prefrontal cortex (PFC) of C57BL/6 (B6) mouse. Exp. Biol. late breaking abstract, 2003.

A104. Puscau, C., H.A. Baghdoyan, and R. Lydic. Expression of M2 muscarinic

receptor protein varies as a function of brain region and mouse strain. FASEB Journal 17: 78.12, 2003.

A105. Bowman, G.N., C.L. Douglas, H.A. Baghdoyan, and R. Lydic. Neostigmine-

induced REM sleep enhancement in C57BL/6J (B6) mouse is concentration-dependent and blocked by atropine. Sleep 26: A1, 2003.

A106. Bernard, R., R. Lydic, and H.A. Baghdoyan. Pertussis toxin (PTX) blocks

hypocretin-1-stimulated G protein activation in rat pontine reticular nucleus, oral part (PnO). Soc Neurosci Abstr 29: 930.9, 2003.

A107. Coleman, C.G., H.A. Baghdoyan, and R. Lydic. Pertussis toxin-sensitive G

proteins modulate the neostigmine-induced rapid dye movement (REM) sleep-like state in C57BL/6J (B6) mouse. Soc Neurosci Abstr 29: 930.7, 2003.

A108. Douglas, C.L., H.A. Baghdoyan, and R. Lydic. Pontine carbachol decreases

acetylcholine (ACh) release in basal forebrain, decreases EEG spindles, and increases slow-waves in prefrontal cortex of rat. Soc Neurosci Abstr 29: 930.8, 2003.

A109. Lydic, R., K. Wiesenauer, and H.A. Baghdoyan. Acetylcholine (ACh) release in

cat prefrontal cortex (PFC) is decreased during rapid eye movement (REM) sleep, carbachol-induced REM sleep, and anesthesia. Soc Neurosci Abstr 29: 930.6, 2003.

Ralph Lydic

A110. Bernard R., A. Hill, L.A. Morgan, E. Skulsky, R. Lydic, T. Shiba, S. Nishino, H.A. Baghdoyan. Orexin/ataxin-3 transgenic mice show increased hypocretin -1-induced G protein activation in the pontine reticular formation. FASEB J 18:394.7, 2004.

A111. Douglas CL, Baghdoyan HA, Lydic R. Strain-specific differences between

C57BL/6J (B6) and B6.V-Lepob (ob) mice in the cholinergic modulation of sleep and breathing. Soc Neurosci Abstr 30:663.2, 2004.

A112. Coleman, C.G., Baghdoyan HA, Lydic R. Adenosine A2A receptors in the pontine

reticular formation of C57BL/6J mouse modulate acetylcholine release. Soc Neurosci Abstr 30:663.1, 2004.

A113. Bernard, R., Lydic R, Baghdoyan HA. Hypocretin 2 receptors modulate

acetylcholine release in rat pontine reticular nucleus, oral part via non-inhibitory G proteins. Soc Neurosci Abstr 30:546.2, 2004.

A114. Liu,F, Baghdoyan HA, Lydic R. Adenosine A1 receptor agonist in the pontine

reticular formation of C57BL/6J mouse suppresses breathing. Soc Neurosci Abstr 30:78.2, 2004.

A115. Osman,NI, Hill A, Baghdoyan HA, Lydic R. Microdialysis delivery of morphine

sulfate to the substantia inominata decreases acetylcholine release in the prefrontal cortex. Soc Neurosci Abstr 30:546.1, 2004.

A116. Kimlin, E.J., Norat M.A., Lydic R. Adenosine in the pontine reticular formation

depresses arousal in C57BL/6J mouse. Neurosci Abstr 30: 78.3, 2004. A116. Soto-Calderon H, Lydic R, Baghdoyan HA. GABA levels are increased in the

pontine reticular nucleus, oral part (PnO) of anesthetized rat by dialysis administration of hypocretin-1 (orexin A). Sleep 28 (Abstr Suppl):0036, 2005.

A117. Watson CJ, Baghdoyan HA, Lydic R. Morphine sulfate dialyzed into the pontine

reticular nucleus, oral part (PnO) of unanesthetized rat decreases PnO levels of GABA. Sleep 28 (Abstr Suppl):0008, 2005.

A118. Chang T, Jeng SM, Lydic R, Baghdoyan HA. Pontine reticular formation (PRF)

microinjection of the GABAA receptor antagonist bicuculline enhances rapid eye movement (REM) sleep in C57BL/6J (B6) mouse. Soc Neurosci Abstr 31: Program No. 64.1, 2005.

A119. Coleman CG, Baghdoyan HA, Lydic R. Dialysis delivery of an adenosine A2A

receptor agonist to the pontine reticular formation (PRF) of C57BL/6J (B6) mouse increases PRF acetylcholine (ACh) release and rapid eye movement (REM) sleep. Soc Neurosci Abstr 31: Program No. 64.3, 2005.

A120. Hambrecht VS, Vlisides PE, Row BW, Gozal D, Baghdoyan HA, Lydic R.

Cholinergic G protein activation is decreased in the prefrontal cortex of Sprague-Dawley rats exposed to intermittent hypoxia. Soc Neurosci Abstr 31: Program No. 64.5, 2005.

Ralph Lydic

A121. Jespersen B, Ignasiak D, Baghdoyan HA, Lydic R. Microdialysis delivery of an

adenosine deaminase inhibitor to the pontine reticular formation (PRF) of C57BL/6J (B6) mouse and Sprague-Dawley rat increases PRF adenosine. Soc Neurosci Abstr31: Program No, 64.4, 2005.

A122. Skulsky EM, Osman NI, White JA, Baghdoyan HA, Lydic R. Acetylcholine (ACh)

release is increased by microdialysis delivery of morphine sulfate to hypoglossal nucleus and pre-Bötzinger complex of Wistar rat. Soc Neurosci Abstr Program No. 308.7, 2005.

A123. Watson CJ, Baghdoyan HA, Lydic R. Dialysis administration of morphine sulfate

to the pontine reticular nucleus, oral part (PnO) of Sprague-Dawley rat causes a concentration dependent decrease in PnO GABA levels. Soc Neurosci Abstr 31: Program No. 64.2, 2005.

A124. Chang T, Vihtelic CM, Gold C, Lydic R, Baghdoyan HA. Microinjection of the

GABAA receptor antagonist bicuculline into the pontine reticular formation of C57BL/6J mouse decreases wakefulness and increases sleep. Sleep 29 (Abstr Suppl): 0022, 2006.

A125. Skulsky EM, Osman NI, Baghdoyan HA, Lydic R. Acetylcholine release in the

pre-Bötzinger complex of Wistar rat is increased by microdialysis delivery of morphine sulfate. Sleep 29 (Abstr Suppl): 0023, 2006.

A126. Van Dort C, Baghdoyan HA, Lydic R. Dialysis administration of the adenosine

A1 receptor agonist N6-p-sulfophenyladenosine into the prefrontal cortex of C57BL/6J mouse decreases prefrontal cortex acetylcholine release and delays anesthesia wake-up time. Sleep 29 (Abstr Suppl): 0010, 2006.

A127. Wang W, Watson S, Baghdoyan HA, Lydic R. Nociception is decreased by

cholinomimetics and the adenosine A1 receptor agonist N6-p-sulfophenyladenosine, but not morphine, microinjected into the pontine reticular formation of C57BL/6J mouse. Sleep 29 (Abstr Suppl): 0012, 2006.

A128. Lydic, R. Neurochemical modulation of sleep and analgesia. Pain Research

and Management 11: 105, 2006. A129. Watson CJ, Walther KJ, Lydic R, Baghdoyan HA. Microinjection of hypocretin-1

(hcrt) or nipecotic acid (NPA) into the pontine reticular nucleus, oral part (PnO) of Sprague-Dawley rat increases wakefulness (W) and decreases sleep. Soc Neurosci Abstr 32: 157.15, 2006.

A130. Hambrecht VS, Vlisides PE, Row BW, Gozal D, Baghdoyan HA, Lydic R.

Hypoxia alters G protein activation by carbachol in the hippocampus of Sprague-Dawley rat. Soc Neurosci Abstr 157.13, 2006.

A131. Icaza EE, Fu Y, Huang X, Neubig RR, Baghdoyan HA, Lydic R. Role of an

inhibitory G protein (Gai2) and regulators of G protein signaling (RGS proteins) in isoflurane anesthesia. Soc Neurosci Abstr 32: 795.3, 2006.

Ralph Lydic

A132. Watson SL, Watson CJ, Baghdoyan HA, Lydic R. Response to nociceptive input

is decreased by the adenosine A1 receptor agonist N6-p-sulfophenyladenosine (SPA), but not by hypocretin-1 (hcrt), microinjected into the pontine reticular formation (PRF) of Sprague-Dawley rat. Soc Neurosci Abstr 32: 248.5, 2006.

A133. Van Dort CJ, Baghdoyan HA, Lydic R. .Microdialysis delivery of caffeine or an

adenosine A1 receptor antagonist to the prefrontal cortex (PFC) of C57BL/6J (B6) mouse decreases anesthesia wake-up time and increases PFC acetylcholine (ACh) release. Soc Neurosci Abstr 32: 157.14, 2006.

A134. Wang W, Watson SL, Baghdoyan HA, Lydic R. Nociceptive responses following

pontine reticular formation (PRF) microinjection of cholinomimetics, the adenosine A1 receptor agonist N6-p-sulfophenyladenosine (SPA), and morphine differ between C57BL/6J (B6) and C57BL/6J-Lepob (obese) mice. Soc Neurosci Abstr 32: 248.4, 2006.

A135. Vanini G, Watson CJ, Soto-Calderon H, Lydic R, Baghdoyan HA. GABA levels

in cat pontine reticular formation (PRF) and pedunculopontine tegmental nucleus (PPT) vary with arousal state. Soc Neurosci Abstr 32: 458.15, 2006.

A136. Flint RR, Lydic R, Baghdoyan HA. Microinjection of the GABAA receptor agonist

muscimol into the pontine reticular nucleus, oral part (PnO) of C57BL/6J (B6) mouse increases wakefulness and decreases sleep. Sleep 30 (Abstr Suppl):0006, 2007.

A138. Van Dort CJ, Baghdoyan HA, Lydic R. Microdialysis delivery of an adenosine

A2A receptor agonist to the prefrontal cortex of C57BL/6J mouse decreases anesthesia wake-up time and increases acetylcholine release. Sleep 30 (Abstr Suppl):0001, 2007.

A139. Vanini G, Watson CJ, Bouchard LA, Lydic R, Baghdoyan HA. GABA levels in

substantia innominata (SI) of cat basal forebrain are state dependent. Sleep 30 (Abstr Suppl):0008, 2007.

A140. Wang W, Baghdoyan HA, Lydic R. Leptin increases antinociceptive responses

in C57BL/6J-Lepob (obese) mice following microinjection of neostigmine into the pontine reticular formation (PRF). Sleep 30 (Abstr Suppl):0009, 2007.

A141. Zhu Z, Baghdoyan HA, Lydic R. Morphine increases principal sensory

trigeminal nucleus (PSTN) acetylcholine (ACh) release in anesthetized Wistar rat via GABAergic disinhibition. Sleep 30 (Abstr Suppl):0005, 2007.

A142. Hambrecht VS, Vlisides PE, Row BW, Gozal D, Baghdoyan HA, Lydic R. G

proteins in the prefrontal cortex (PFC) of Sprague-Dawley rat are differentially activated as a function of oxygen (O2) status and PFC region. Sleep 30 (Abstr Suppl):0019, 2007.

A143. Icaza EE, Fu Y, Huang X, Neubig RR, Baghdoyan HA, and Lydic R. Genomic

Knock-in Mice with Enhanced Gai2 Signaling Exhibit Altered Breathing During

Ralph Lydic

Recovery from Isoflurane Anesthesia Compared to Wild Type Mice. Sleep 30 (Abstr Suppl):0024, 2007.

A144. Puro AK, Baghdoyan HA, and Lydic R. Glucose microinjected into the pontine

reticular formation (PRF) of anesthetized C57BL/6J (B6) mouse decreases PRF acetylcholine (ACh) release. Sleep 30 (Abstr Suppl):0039, 2007.

A145. Flint RR, Lydic R, Baghdoyan HA. Microinjection of the GABAA receptor agonist

muscimol into the pontine reticular nucleus, oral part (PnO) of C57BL/6J (B6) mouse causes a concentration dependent increase in wakefulness and decrease in sleep. Society for Neuroscience Abstract Viewer/Itinerary Planner, Online: Program No. 631.5, 2007.

A146. Icaza EE, Huang X, Neubig RR, Baghdoyan HA, Lydic R. Aged genomic knock-

in mice with enhanced Gai2 signaling exhibit greater respiratory depression during recovery from isoflurane anesthesia than younger knock-in mice and wild type mice. Society for Neuroscience Abstract Viewer/Itinerary Planner, Online: Program No. 878.19, 2007.

A147. Puro AK, Baghdoyan HA, Lydic R. Microdialysis delivery of cytochalasin B to

the pontine reticular formation (PRF) decreases PRF acetylcholine (ACh) release in anesthetized C57BL/6J (B6) mouse. Society for Neuroscience Abstract Viewer/Itinerary Planner, Online: Program No. 631.12, 2007.

A148. Van Dort CJ, Baghdoyan HA, Lydic R. Microinjection of an adenosine A1

receptor antagonist into the prefrontal cortex of C57BL/6J (B6) mouse increases wakefulness and decreases non-rapid eye movement (NREM) sleep. Society for Neuroscience Abstract Viewer/Itinerary Planner, Online: Program No. 771.1, 2007.

A149. Vanini G, Bouchard LA, Watson CJ, Lydic R, Baghdoyan HA. GABA levels in

substantia innominata (SI) of cat basal forebrain during sleep and wakefulness. Society for Neuroscience Abstract Viewer/Itinerary Planner, Online: Program No. 631.1, 2007.

A150. Wang W, Baghdoyan HA, Lydic R. Leptin attenuates the antinociceptive

response in C57BL/6J-Lepob mice following microinjection of neostigmine into the pontine reticular formation (PRF). Society for Neuroscience Abstract Viewer/Itinerary Planner, Online: Program No.631.4, 2007.

A151. Wathen AB, Lydic R, Baghdoyan HA. Microdialysis delivery of the atypical

antipsychotic olanzapine to the prefrontal cortex (PFC) of C57BL/6J (B6) mouse increases PFC acetylcholine (ACh) release and shortens recovery time from anesthesia. Society for Neuroscience Abstract Viewer/Itinerary Planner, Online: Program No. 631.2, 2007.

A152. Watson CJ, Lydic R, Baghdoyan HA. Microinjection of 3-mercaptopropionic acid

(3MPA) into the pontine reticular nucleus, oral part (PnO) of Sprague-Dawley rat decreases wakefulness (W) and increases sleep. Society for Neuroscience Abstract Viewer/Itinerary Planner, Online: Program No. 631.3, 2007.

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A153. Nelson AM, Ignasiak D, Baghdoyan HA, Lydic R. Microdialysis delivery of

morphine sulfate to rat pontine reticular formation (PRF) decreases PRF adenosine levels. FASEB Journal 22: 945.11, 2008.

A154. Muncey A, Salleus A, Baghdoyan HA, Koch LG, Britton SL, Lydic R. Rats bred

for low intrinsic aerobic running capacity recover more slowly from chronic pain compared to rats bred for high intrinsic aerobic capacity. FASEB Journal 22: 945.9, 2008.

A155. Bowman HR, Zhu Z, Baghdoyan HA, Lydic R. Acetylcholine release in rat

trigeminal motor nucleus is increased by microdialysis delivery of morphine. The FASEB Journal 22: LB148, 2008.

A156. Watson SL, Watson CJ, Baghdoyan HA, Lydic R. Microinjection of hypocretin-1

into the pontine reticular nucleus, oral part (PnO) of Sprague-Dawley rat decreases response to nociceptive input. J. Pain 9:(Suppl.2) 7, 2008.

A157. Muncey A, Salleus A, Baghdoyan HA, Koch LG, Britton SL, Lydic R. Rats bred

for low intrinsic aerobic running capacity exhibit decreased and more disrupted sleep compared to those bred for high intrinsic aerobic running capacity. Sleep 31 (Abstr Suppl): A27, 2008.

A158. Muncey A, Salleus A, Baghdoyan HA, Koch LG, Britton SL, Lydic R. Poincaré

analyses provide novel insights into the temporal organization of sleep. Sleep 31 (Abstr Suppl): A339, 2008.

A159. Gettys GC, Hambrecht VS, Baghdoyan HA, Lydic R. Microdialysis delivery of

the adenosine A1 receptor agonist N6-sulfylphenyl adenosine (SPA) to the pontine reticular formation (PRF) of C57BL/6J (B6) mouse decreases PRF acetylcholine (ACh) release and delays recovery time from isoflurane anesthesia. Sleep 31 (Abstr Suppl): A8, 2008

A160. Brevig HN, Watson CJ, Lydic R, Baghdoyan HA. The hypocretin-1 (hcrt-1)-

induced increase in wakefulness and decrease in sleep is blocked by bicuculline or the hypocretin receptor-1 (hcrt-r1) antagonist SB-334867. Society for Neuroscience Abstract Viewer/Itinerary Planner, Online: Program No. 285.14, 2008.

A161. Flint RR, Lydic R, Baghdoyan HA. In C57BL/6J (B6) mouse the GABAA receptor

antagonist bicuculline blocks the increase in wakefulness and decrease in sleep caused by the GABAA receptor agonist muscimol. Society for Neuroscience Abstract Viewer/Itinerary Planner, Online: Program No. 285.15, 2008.

A162. Gettys G, Baghdoyan HA, Lydic, R. Microdialysis delivery of the adenosine A1

receptor antagonist 1,3-Dipropyl-8-cyclopentylxanthine (DPCPX) to the pontine reticular formation (PRF) of C57BL/6J (B6) mouse increases PRF acetylcholine (ACh) release and decreases recovery time from isoflurane anesthesia. Society for Neuroscience Abstract Viewer/Itinerary Planner, Online: Program No. 285.17, 2008.

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A163. Hambrecht VS, Baghdoyan HA, Lydic R. Microdialysis delivery of eszopiclone,

zolpidem and diazepam to the pontine reticular formation (PRF) of rat increases PRF acetylcholine (ACh) release. Society for Neuroscience Abstract Viewer/Itinerary Planner, Online: Program No. 285.16, 2008.

A164. Vanini G, Watson CJ, Wathen B, Lydic R, Baghdoyan HA. GABAergic

transmission in the oral part of the pontine reticular formation of Sprague-Dawley rat modulates loss of wakefulness caused by isoflurane anesthesia. Society for Neuroscience Abstract Viewer/Itinerary Planner, Online: Program No. 565.4, 2008.

A165. Watson CJ, Lydic R, Baghdoyan HA. On-line capillary electrophoresis with

laser-induced fluorescence (CE-LIF) reveals that glutamate and GABA levels, but not aspartate, taurine, serine, or glycine levels, in rat pontine reticular nucleus, oral part (PnO) are greater during wakefulness (W) than during sleep. Society for Neuroscience Abstract Viewer/Itinerary Planner, Online: Program No. 188.9, 2008.

A166. Watson SL, Battersby AS, Watson CJ, Baghdoyan HA, Lydic R. Increase in

antinociception caused by microinjection of hypocretin-1 (hcrt-1) into the pontine reticular nucleus, oral part (PnO) of Sprague Dawley rat is blocked by the hcrt receptor-1 (hcrt-r1) antagonist SB-334867. Society for Neuroscience Abstract Viewer/Itinerary Planner, Online: Program No. 270.18, 2008.

A167. Battersby AS, Guzick SE, Baghdoyan HA, Lydic R. Microdialysis delivery of

morphine decreases adenosine levels in rat basal forebrain and coadministration of an adenosine deaminase inhibitor reverses the morphine-induced decrease. Sleep 32 (Abstr Suppl): 0017, 2009.

A168. Brevig HN, Watson CJ, Lydic R, Baghdoyan HA. Hypocretin-1 microinjected

into the pontine reticular nucleus, oral part (PnO) of Sprague-Dawley rat causes a concentration dependent increase in wakefulness and decrease in sleep. Sleep 32 (Abstr Suppl): 0018, 2009.

A169. Flint RR, Lydic R, Baghdoyan HA. Electroencephalogram (EEG) power during

wakefulness and rapid eye movement (REM) sleep is increased by microinjection of the GABAA receptor agonist muscimol into the pontine reticular nucleus, oral part (PnO) of C57BL/6J (B6) mouse. Sleep 32 (Abstr Suppl): 0194, 2009.

A170. Hambrecht VS, Baghdoyan HA, Lydic R. Pontine reticular formation (PRF)

administration of diazepam and zolpidem, but not eszopiclone increases electroencephalogram (EEG) delta power in Sprague-Dawley rat. Sleep 32 (Abstr Suppl) 0028, 2009.

A171. Vanini G, Wathen BL, Lydic R, Baghdoyan HA. GABA levels in cat pontine

reticular formation (PRF) are lower during rapid eye movement (REM) sleep and the neostigmine-induced REM sleep-like state (REM-Neo) than during wakefulness. Sleep 32 (Abstr Suppl): 0011, 2009.

Ralph Lydic

A172. Wathen AB, West ES, Lydic R, Baghdoyan HA. Olanzapine, an atypical antipsychotic, delivered to the prefrontal cortex (PFC) differentially increases PFC acetylcholine (ACh) release in C57BL/6J (B6) and B6.V-Lepob/J (obese) mouse but does not alter cortical electroencephalographic (EEG) power or behavioral arousal. Sleep 32 (Abstr Suppl): 0037, 2009.

A173. Flint RR, Lydic R, Baghdoyan HA. Microdialysis delivery of the GABAA receptor

antagonist bicuculline to the pontine reticular formation (PRF) of C57BL/6J (B6) mouse increases PRF acetylcholine (ACh) release. . Society for Neuroscience Abstract Viewer/Itinerary Planner, Online: 375.12, 2009.

A174. Watson CJ, Lydic R, Baghdoyan HA. Dialysis delivery of L-trans-pyrrolidine-2,4-

dicarboxylic acid (PDC) to the oral part of rat pontine reticular nucleus (PnO) decreases wakefulness (W), increases non-rapid eye movement (NREM) sleep, and increases PnO levels of glutamate and aspartate. Society for Neuroscience Abstract Viewer/Itinerary Planner, Online: 375.11, 2009.

A175. Vanini G, Teran MA, Zhuo M, Baghdoyan HA Lydic R. GABAergic transmission

in the rat pontine reticular formation (PRF) does not modulate recovery time from isoflurane anesthesia. Society for Neuroscience Abstract Viewer/Itinerary Planner, Online: 375.13, 2009.

A176. West ES, Gerow EA, Wathen AB, Lydic R, Baghdoyan HA. Leptin replacement

in B6.V-Lepob /J (obese) mouse restores the increase in prefrontal cortex (PFC) acetylcholine (ACh) release caused by microdialysis delivery of the atypical antipsychotic olanzapine to the PFC. Society for Neuroscience Abstract Viewer/Itinerary Planner, Online: 375.10, 2009.

A177. Brummett CM, Amodeo FS, Janda AM, Padda AK, Lydic R. Perineural

dexmedetomidine provides an increased duration of analgesia to a thermal stimulus when compared to a systemic control in a rat sciatic nerve block. International Association for the Study of Pain Program PW332, page 74, 2010.

A178. Mitchell MF, Norton KA, Baghdoyan HA, Lydic R. Amygdala acetylcholine levels

in Sprague-Dawley rat are increased by microdialysis delivery of diazepam, zolpidem, and eszopiclone. Sleep 33: A6, 2010.

A179. Hambrecht VS, Gauthier EA, Baghdoyan HA, Lydic R. Acetylcholine (ACh)

release in the pontine reticular formation (PRF) of Sprague-Dawley rat is differentially altered by systemic versus PRF delivery of eszopiclone. Sleep 33: A5, 2010.

A180. Gauthier EA, Baghdoyan HA, Lydic R. Intravenous administration of

buprenorphine to Sprague Dawley rat disrupts normal sleep architecture. J Pain 11: S31, 2010.

A181. Guzick S, Brummett CM, Baghdoyan HA, Lydic R. Microdialysis delivery of

buprenorphine to rat pontine reticular formation does not alter adenosine levels. J Pain 11: S32, 2010.

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A182. Mitchell M, Norton K, Baghdoyan HA, Lydic R. Midazolam and eszopiclone decrease acetylcholine levels in rat amygdala. Anesthesiology (abstract suppl.) A267, 2010.

A183. Diniz Behn C, Pal D, Vanini G, Lydic R, Mashour GA, Booth V. Modeling sleep-

wake temporal architecture in multiple species to investigate underlying physiology of behavioral state regulation. Soc Neurosci Abstracts 300.18, 2010.

A184. Watson CJ, Lydic R, Baghdoyan HA. Duration of sleep episodes in rat varies as

a function of amino acid concentration in the pontine reticular nucleus, oral part. Soc Neurosci Abstracts 500.7, 2010.

A185. Vanini G, Baracy CR, Lydic R, Baghdoyan HA. GABA levels in cat basal

forebrain and cortex are greater during non-rapid eye movement (NREM) sleep than during REM sleep and wakefulness. Soc Neurosci Abstracts 798.1, 2010.

A186. Lazar SB, Garrity, AG, Wang P, Mashour GA, Baghdoyan HA, Lydic R.

Systemic administration of dexmedetomidine (DEX) disrupts sleep architecture and microdialysis delivery of DEX TO rat substantia innominata does not increase adenosine levels. Sleep 34: A7, 2011.

A187. Nemanis K, Vanini G, Baghdoyan HA, Lydic R. GABAergic transmission in

Sprague-Dawley rat pontine reticular formation modulates time required for the general anesthetic propofol to cause loss of wakefulness. Sleep 34: A7, 2011.

A188. Saulles A. Filbey W, Baghdoyan HA, Koch LG, Britton SL, Lydic R.

Dexmedetomidine depresses breathing in a rat model of metabolic syndrome. Soc Neurosci Abstracts, 502.01, 2011.

A189. Garrity AG, Lazar SB, Baghdoyan HA, Lydic R. Dexmedetomidine disrupts the

temporal organization of sleep and wakefulness in Sprague-Dawley rat. Soc Neurosci Abstracts, 286.09, 2011.

A190. Lazar SB, Garrity, AG, Mashour GA, Baghdoyan HA, Lydic R.

Dexmedetomidine, adenosine, and sleep: convergence or conflation. British Journal of Anaesthesia 108: 334-67, 2012.

A191. Hambrecht-Wiedbusch VS, Bender MC, Bellefleur MP, Baghdoyan, HA Neubig

RR, Lydic, R. Do RGS proteins in sleep-regulating regions of prefrontal cortex (PFC) and pontine reticular formation (PRF) of mouse influence adenosinergic and cholinergic signaling? SLEEP 35: (In Press) 2012.

A192. Hambrecht-Wiedbusch VS, Davidov A, Koch LG, Britton SL, Baghdoyan HA,

Lydic R. Microdialysis delivery of the sedative/hypnotic eszopiclone to the basal forebrain differentially increases acetylcholine release in the basal forebrain of lean/fit (HCR) and obese/metabolic syndrome (LCR) rats. SLEEP 35: (In Press) 2012.

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A193. Sanford D, Filbey W, Koch LG, Britton SL, Baghdoyan HA, Lydic R. Systemic administration of eszopiclone depresses ventilation in a rat Model of metabolic syndrome. SLEEP 35: (In Press) 2012.

A194. Shatsman A, Watson CJ, Norton CC, Lydic R, Baghdoyan HA. GABA levels in

the oral pontine reticular formation (PnO) of C57BL/6J mouse are increased by neostigmine. SLEEP 35: (In Press) 2012.

A195. Watson SL, Frank MJ, Watson CJ, Baghdoyan HA, Lydic R. Microinjection of the

adenosine A1 receptor agonist N6-p-sulfophenyladenosine (SPA) into the pontine reticular formation (PRF) of C57BL/6J mouse increases antinociception in a concentration-dependent manner. J Pain 13: (In Press) 2012

Lydic CV 20Feb12

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