Liver Gallbladder Common bile duct Pancreas Pancreatic duct Duodenum Biliary and Pancreatic Anatomy.

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Transcript of Liver Gallbladder Common bile duct Pancreas Pancreatic duct Duodenum Biliary and Pancreatic Anatomy.

  • Slide 1
  • Liver Gallbladder Common bile duct Pancreas Pancreatic duct Duodenum Biliary and Pancreatic Anatomy
  • Slide 2
  • Islet cell secreting hormones Cells secreting pancretic juice Insulin and glucagon Pancretic duct Duodenum Pancreas Common bile duct Blood Pancreatic Anatomy
  • Slide 3
  • Pancreatic Secretions Acinar Enzymes Digestion Ductal HCO 3 and Water Protection Digestion Cell Type Component Function:
  • Slide 4
  • ATP cAMP Adenyl cyclase ? ? Ca 2+ stores Secretin Ach CCK Enzymes IP 3 The Hormones also Modulate Enzyme Expression Primary Stimulus PANCREATIC ACINAR CELL
  • Slide 5
  • Ca 2+ CCK Pancreatic Duct Cell
  • Slide 6
  • Regulators of Pancreatic Secretion AcinarCCK / Ach Secretin Ductal Secretin CCK / Ach Cell Type PrimaryActivator Potentiator (Ca 2+ ) (cAMP ) Cephalic and Gastric: Neural Ach Intestinal : Hormonal
  • Slide 7
  • Liver Hepatic Ducts Right Left Common Bile Duct Cystic Duct Gallbladder Ampulla of Vater Duodenal Lumen Pancreatic Duct Sphincter of Oddi
  • Slide 8
  • Excretory Component - Bilirubin, Drug Metabolites. Secretory Component -Bile: Produced and Filtered by Hepatocytes Primary Bile Acids: Cholic Acid, Chenodeoxycholic Acid -Secondary Bile Acids - Formed by Bacteria in the Intestine : Deoxycholic Acid, Lithocholic Acid
  • Slide 9
  • Bile Acids Primary bile acids Secondary bile acids Cholesterol Cholic acid Deoxycholic acid Chenodeoxycholic acid Lithocholic acid Liver Intestine Cholesterol 7-hydroxylase 80% 20% Fraction of Total Amphipathic Carboxylic Acids
  • Slide 10
  • C Have both Hydrophilic and Hydrophobic domains Formation of Micelles Co-Lipase Bile Acids are Amphipathic
  • Slide 11
  • Central vein Hepatic cell plate Bile canaliculus Venous sinusoid Terminal bile duct Kupffer cell Portal venule
  • Slide 12
  • Aorta (200) Celiac (700) Portal Vein Superior Mesenteric (700) Inferior Mesenteri c (400) LIVER STOMACH SPLEEN PANCREAS SMALL INTESTINE COLON To Systemic Circulation (1800) mls/min HEPATIC Rates: ml/min
  • Slide 13
  • Cholesterol 7-hydroxylase Newly synthesized bile acids (0.6 g/24 h) Cholesterol 2 - 4 g bile-acid pool : circulated 6 - 10 times in 24 h Excreted bile acids (0.6 g/24 h) Liver Bile ducts Portal vein Colon Small intestine Stomach Enterohepatic Circulation
  • Slide 14
  • SECRETIONS of the INTESTINES Information pertaining to the next 3 slides is found in the Lecture Notes for the last Lecture
  • Slide 15
  • Blood vessels Lymph vessels Nerves Smooth muscle Connective tissue lymphocytes Plasma cells Eosinophiles Villous epithelium Undifferentiated Goblet Mitoses Endocrine cells Crypt epithelium Crypt lumen Muscularis mucosa Absorp- tive cells Goblet cells Endocrine cells Cell Loss
  • Slide 16
  • Crypts of Lieberkuhn: Small and Large Intestine -Contain Primarily Epithelial Cells, Mucus Goblet Cells, and Endocrine Cells. -Water Secretion - VIP Activates Water Secretion by Elevating cAMP and Cl - conductance. -Cell Growth and Differentiation: Cell Turnover at the Tip of a Villus is High (3-6 day Cycle). Secretions of the Small Intestine (2000 ml/day)
  • Slide 17
  • Crypt Secretion H2OH2O 2 Cl - Na + K+K+ PDte cAMP ? Ca 2+ Cl - Na + ATP ADP + Pi 3 Na + 2 K + Key Players: cAMP Activated Cl - Channel Na + / K + / Cl - Co-transport Na-K ATPase VIP neurotransmitter Histamine also can activate