KOSThe microwave multifunctional

tissue processor you were waiting for

In a fraction of the time

• Tissue processing

• Decalcification

• Special stains

• Gross hardening

• Fixation

•Antigen retrieval (93°C to 120°C)

KOS

KOS: Smart and Fast

The first Icon driven HistoStation

• Multifunctional: 1 unit 6 applications

• Fast: Just plug-in and process

• Reliable: Sensors controlled

• Flexible: User programs / Favorites

• Safe: Sensors monitored

• Smart: Icons driven

KOS*

Multifunctional: ONE unit SIX major applications

• Fulfilling all requirements set by CAP/C.L.S.I.

• Ideal substitute for “kitchen type” microwave oven

• Fulfilling all requirements set by CAP/C.L.S.I.

• Ideal substitute for “kitchen type” microwave oven

Rapid Tissue processingSame day results for all tissue types.

• From 1 to 45 cassettes

• Ideal for transplant center

• Urgent biopsies

• Up to 3 mm thickness

• Safe. No xylene

• Ethanol – isopropanol only

Fast, unmatched tissue processing time

.

• 35 minutesFor transplant biopsies including fixation

• 75 minutesFor 2 mm biopsiesAdd 18 min fixation

• 140 minutesFor 3 mm biopsiesAdd 28 min fixation

Excellent H&E, IHC and FISHIn a fraction of the time

High Quality Slides

Breast Red-Labeled HER2-FISH, x800

Colonic BiopsyH&E, x400

AdenocarcinomaCytokaratin

CAM 5.2, x400

Breast, HER2IHC, x400

SMART . ICONS DRIVEN MENU

1) Select thickness.

2) Select number of cassettes.

3) Select reagents

4) Press GO

5) Press START.That’s all

Time left will be shown on the terminal

Bone Marrow processingSame day diagnosis for bone marrow trephine biopsies.

Decalcification + processing in less than 3 hours

EDTA.

Decalcification: 80 minutes

Processing: 60 minutes

Total time: 140 minutes

FORMIC ACID (10%).

Decalcification: 20 minutes

Processing: 60 minutes

Total time: 80 minutes

Rapid Bone decalcificationUp to 45 cassette – 60 Mega cassette

Hours, not days

Magnetic stirring plus microwave energyPositively influence the equilibrium

1. Select temperature, 2. Number of cassette, 3. Decalcifyng solution

Press GO

Special StainsUp to 16 slides

Up to 76% time saving for staining protocols

1) Select stains menu

2) Select specific stain

3) Follow step by step indications

4) Selected program is prestored ready to

use.

Antigen Retrieval Time At Temperature Protocols

Up to 80 slides

Dedicated Histomodules

4K, up to 4 cassette

45K, up to 45 cassette

16s, up to 16 slides

40s, up to 80 slides

Decal, up to 60 Megacassette

• Dedicated fixation histomodule up to 45 cassette

• Select time at temperature protocol to fulfill all requirements of standardization and documentation for CAP/ASCO for HER2/ER.

• Factory stored opitimized protocols at 37°C - 50°C guarantee consistent results

Fixation

• Dedicated GHK hardening module

• Efficient & rapid hardening in physiologic solution for a timely grossing

• Factory stored opitimized protocols at 50°C – 65°C guarantee consistent results

Gross Hardening

Glass Pressure Reactor-120°C

GPR-120°C

SuperHeating

Antigen Retrieval

(40 slides)

Dedicated Histomodules

Processing & Infiltration

Resin polymerization

KOS EM demo

KOS EM demo

• Better Quality and TAT (2-3 days vs same day diagnosis)

• Users were satisfied because fully supported during demo, installation and training (Competitors were won also because of this)

• KOS is not automatic but users understand that gives benefits in speed + quality and price

KOS

Packed with the latest microwave and sensor technology.Controlled by the most advanced, intuitive software.

State of the Art

Microwave is switched OFF if:

1.Cavity ventilation is compromised

2.Solvent in cavity is above Threshold

3.Humidity in cavity exceeds set value

4.Microwave leak is detected

Any protocol as Favorite

Last but not least…In 3 “stainful” colors to fit theatmosphere of your laboratory

Congo Red - GMS Green - Alcian Blue

KOS: 10 Good Reasons to Choose1. Not a modified kitchen applianceIndustrial engineered, laboratory grade, microwave unit designed

specifically for histology applications.

2. Easy-to-use• Why make things complicated? • Our icons driven user interface allows you to access information

quickly.• Basic user maintenance.

3. Optimized protocols• Factory stored for tissue processing, decalcification, fixation, gross hardening, special stains and EM• User’s defined protocols can be stored and, if required, included in a “Favorites” menu for easy retrieval.

4. Fully compliantWe have always been concerned with Safety and Quality. Our laboratory

grade microwaves fully comply with CAP-C.L.S.I. Guidelines.

5. Full Tech supportWith over 70 years of combined histology experience our applications support

professionals have the answer to your questions.

6. Specimen safety• Focused infrared automatic temperature control with laser positioning.• Software controlled magnetic stirring for homogeneous temperature

distribution• Built-in re-generable charcoal filter on exhaust outlet

7. Lab safetySensors controlled operation. Built-in sensors will switch off microwave if:• Cavity ventilation is compromised• Solvent & Humidity in cavity is above threshold• Microwave leak is detected

8. Full documentationThrough a USB port, data from the built-in Logbook can be easily downloaded

for documentation Purposes (Q.A. - ISO 9001 - G.L.P.)

9. TV 7’ monitoring for easy observation of process in cavity.

10. Unique histomodule technology for easy, safe handling of solutions while preserving the pH of the solution throughout the procedure.

Milestone HistosBench top microwave

Dual multifunctional tissue processor

• Fixation and Tissue processing • Decalcification • Special stains

• Gross hardening

In a fraction of the time

• Processing performance

• Reagent efficiency

• Environmental sensitivity

• High quality results

HISTOS line

Histos Processing TimeThickness

35 min (+10 min fix.)

1.15 hr (+20 min fix.)

4.30 hr (+60 min fix.)

Simplicity

• NO need to change your grossing procedure

• NO need for special grossing tools

• Software driven procedures

• No cleaning cycles

Safety• Fixation with either formalin or Milestone’s FineFIX

• XYLENE free processing

• Exhaust fan

• Safety micro-switches

• Fume sensors

• Methods and process reports can be stored and exported

High throughputHistoprocessing of batches with up to 110 standard cassettes…

…and of batches with up to 16 Mega and 8 SuperMega

cassettes.

High throughput

The Proof ?

Is in the microscopic comparison

• Excellent results in a fraction of the time

• No compromise in regard to morphology and “staining”

expression

Quality equal or better than conventional histoprocessing for H&E, IHC,

FISH

Benefits Benefits Vs Conventional Vs Conventional systemssystems

• Fast processing and Same day results

• Flexibility in the processing

• Results equal or better than conventional

• Flexibility in workflow (no peaks)

• Dual processing and High throughput (110 Cass in 40-240 min)

• More healthy environment

• Cost saving (reagents and wax disposal)

Benefits Benefits for for all!all!

• Patient: - Same day results, less stress time

waiting for results

• Histologist: - Improved working conditions

- Work load with less peaks

• Pathologist: - “Same day” and high quality slides even for difficult tissues

• Administrator: - Reduced cost / cassette- Rapid turn around time

PRESENTING ’11 HistosLINE

Histos5

Histos3

• Microwave unit + single external retort (Wax module)

• Parallel processing, double productivity

• Up to 3mm thickness & 110 cassette

• No Vacuum

• Multifunctional

HISTOS3

The HISTOS3 is designed for small to medium size histology labs

•small to medium size biopsies

• Ideal for Transplant center

HISTOS3

• Microwave unit + double external retort (Dry module, Wax module)

• Parallel processing, double productivity

• Vacuum, 110 cassette

• Up to 7mm thickness

• Multifunctional

HISTOS5

HISTOS5 is designed for hospital laboratories

• high throughput processor for same day routine

• wide variety of tissues without compromising tissue block thickness.

• Multifunctional unit for Pathos users

HISTOS5

MILESTONE concept

Epitope Retrieval – Decalcification Fixation – Special Staining - Gross Hardening

…in a single unit!

MILESTONE multiple functions concept

Histos: direct access

Histos: Double processing

• Processing modules up to 110 cassette

• Fast protocol for urgent transplant biopsies (40’)

• Processing of samples up to 7mm thickness

• No xylene

• No proprietary reagents

• Excellent morphology, staining & IHC properties

Tissue processing

• Processing modules for 110 cassette

• Decal + processing in as little as 80minutes

• No proprietary reagents – Preset protocols

• Decalcification with either EDTA or acids

Decalcification

• Processing modules for up to 12 slides

• Save up to 76% of the time vs standard method

• Factory optimized stored methods guarantee consistent results

• No proprietary reagents

• No splashing, constant pH and temperature

Special Stains

Epitope Retrieval

• Processing modules for up to 120 slides

• Factory opitimized stored methods guarantee consistent results

• Standard methods at 98°C

• GPR up to 120°C

• No splashing, constant pH and temperature

• Whole organ hardening module

• Physiologic solution is the reagent

• Efficient & rapid hardening for a timely grossing

• Factory stored opitimized methods guarantee consistent results

Gross Hardening