TOWARD MULTIFUNCTIONAL

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TOWARD MULTIFUNCTIONAL CLICKABLE NANOPARTICLESVolodymyr Turcheniuk, Aloysius Siriwardena, Vladimir Zaitsev, and Sabine SzuneritsInstitute of Electronics, Microelectronics and Nanotechnology, Universite Lille 1, FranceTaras Shevchenko University of Kiev, UkrainePontifcia Universidade Catlica do Rio de JaneiroLaboratoire de Glycochimie des Antimicrobiens et des Agroressources, Universite de Picardie, Amiens, France

Professor Vladimir ZaitsevD.Sc., Ph.D., corr. Memb. NAS Ukraine

Iron oxide magnetic nanoparticles with versatile surface functions based on dopamine anchorsSiO2,ZrO2,TiO2SiC,CSi

Nanoscale, 2013, 5, 2692 Cited - 22

www.achem.univ.kiev.uaRESEARCH INTERESTSChemistry on the interface: immobilised reagent /solutionImmobilised layer topography and its influence for the material propertiesImmobilised metal complexes composition and stabilitySynthesisApplicationSurface-modified materialsInvestigationSolid-phase analytical reagentsTest-systems for simple analysisAdsorbents for selective pre-concentrationNew chromatographic phasesCatalytically active materialsChemical and biosensorsDrug delivery systemsFundamental problems

4

Structure of Research activity

5

Several examples of Organo-mineral composite Materials (OMCM),

Solid acids and basesIon-exchangersChelating compounds

www.achem.univ.kiev.uaCHELATING SILICA-BASED MATERIALS

7

81. Sommaire de catalyseurs acides prepare et leurs application est presente en tableu. 2. Pour la preparation de ces materiaux nous avont greffe les silices avec de groupement basic daminopropyl et anion-echangeant: sels donium propylpyridinium et propylimidazolium. 3. Preparation des materiaux etais variee a letape de silanisation afin de changer leurs hydrophobicite et distribution de sites actives et etudier linfluence a la performence catalytique. Par exemple, les supports aminopropylees etions modifiee, par les groupement TMS, pour les support pyridinium deux types de la couche monomoleculaire ou polymeric etais etudier. 4. Quatre acides de Keggin, adsorbe sur ces supports, etions evaluee comme les catalyseurs de synthese dethyl-tertbutyl ether et ethyl acetate.

SiO2-PE-Eu filmsRSO3Na+ + Eu(III) RSO3Eu(III) + Na+

Modification of Graphene oxide with polymer

Infrared Photothermal Therapy with Water Soluble Reduced Graphene Oxide: Shape, Size and Reduction Degree Effects. Nano LIFE 2015 Vol. 5, No. 1

C1s high resolution XPS spectra

Synthesis of hybrid material through covalent interaction

+

Carbodiimide

Graphene coated Gold nanorods

MaterialZeta, mVGold NRs-24.5rGO-PEG-26.2

covalent interaction

1.5 nm

1.7 nm

10 nm

Characterization of hybrid material: TEM and HRTEM images

10 nm

Graphene layerGraphene Layer thickness around 1.7 nmPart 2.HRTEM of Gold-Graphene composite

SEM images of Gold-graphene compositePart 2.Conclusion: we managed to cover Gold Nanorods with layer of reduced Graphene Oxide preserving its stability and solubility in water.SEM image of Gold Nanorods covered with Graphene. Stability tested after 2 months at 4 C

Graphene layer protects Gold Nanorods from degradation!!!SEM image of Gold Nanorods after 2 months at 4 C

Stability

GOGO-COOHrGO-PEGInfrared Photothermal Therapy with Water Soluble Reduced Graphene Oxide: Shape, Size and Reduction Degree Effects. Nano LIFE 2015 Vol. 5, No. 1Remarkable stability at room temperature of GO-PEG within 6 months at room temperature

Photothermal propertios of Gold-Graphene composite.Infrared Photothermal Therapy with Water Soluble Reduced Graphene Oxide: Shape, Size and Reduction Degree Effects. Nano LIFE 2015 Vol. 5, No. 1Biomedical applicationAu-GraphenerGO-PEGGO22C57C

85 CThere was no sign of acute toxicity of rGOPEG for HeLa and MDA-MB-31 cancer cells over a wide concentration range

Relative cell viabilities of HeLa after irradiation

Infrared Photothermal Therapy with Water Soluble Reduced Graphene Oxide: Shape, Size and Reduction Degree Effects. Nano LIFE 2015 Vol. 5, No. 1A complete destruction of the tumor cells could be achieved with a laser power of 6 W/cm2 and a concentration of 60 gm L1 of rGOPEG.

Electrocatalytic sensorsCobalt phthalocyanine tetracarboxylic acid modified reduced graphene oxide: a sensitive matrix for the electrocatalytic detection of peroxynitrite and hydrogen peroxide. RSC Adv., 2015, 5, 1474

Electrocatalytic response rGO/CoPcCOOH modifedglassy carbon electrodes

Cyclic voltammograms on GCE modified by rGO/CoPcCOOH in the absenceand in the presence of 15 nM peroxynitrite in pH 10, and pH 7.4

Electrochemical ReactionCo(II)PcCOOH -> Co(III)PcCOOH + eCo(III)PcCOOH + O=NOO- -> Co(II)PcCOOHOONOCo(II)PcCOOHOONO + e -> Co(III)PcCOOH + ONO22 ONO2 -> O2 + NO2

Amperometric determination of PON using glassy carbon electrode modified with rGO/CoPcCOOH

Selectivity

nitrate, nitrite, hydrogen peroxide, dopamine (DA), Ascorbic acid (AA), glucose (Gl) at 1000 times excess

Silica based activated phases!

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Fe3O4- based activated phases

Horseradish peroxidase (HRP)6-(ferrocenyl)-hexanethiol

UV/Vis spectra (left) and calibration curves (right) recorded with subsequently modified MF-MPs:

(A) MF-MP1; C= 20 mg/g

(B) MF-MP2 (0.5 mg mL1) in 2 mL of a solution containing 20-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) (3.6 mM) and H2O2 (50 mM) (black line) and of naked magnetic particles (dotted grey line); C= 14,6 mg/g -> 30 mg/g

(C) MF-MP3 (recorded after 60 min of immersion of 0.2 mg mL1 MF-MP3 in a phenol-sulfuric acid solution).C= 19 mg/g -> 60 mg/g

Toward Clickable Diamond Nanoparticles

Phenylboronic-Acid-Modified Nanoparticles: Potential Antiviral Therapeutics

2-nitrodopamine

Toward Multifunctional Clickable Diamond Nanoparticles

Langmuir 2015, 31, 39263933

Characterization

StabilitySuspensions of NDdopEG+N3 (50 g/mL) in PBS (pH 7.4, 0.1 M) at different time intervals together with a bar diagram of the change in particle size

4-pentynoic acid

-D-mannopyranoside (-mmp),

The use of PWR in combination with an adapted surface-modification strategy results in detection limits of glycanslecin binding events around 500 pM, comparable to fluorescence based approaches, with the advantage of being label free.

Silice greffeHPAApplication: catalyse acide

H3[PW12O40]

H4[SiW12O40]

H3[PMo12O40]

H4[SiMo12O40]