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Korea BIO and Status of Bio Industry in Korea · pharmaceutical companies Most of 50 bio-technology...
Transcript of Korea BIO and Status of Bio Industry in Korea · pharmaceutical companies Most of 50 bio-technology...
Korea Bio Industry 2
Korea Biotechnology Industry Organization
History
1982. Korea Biotechnology Research Association(KBRA) founded
1991.11 Bio-industry Association of Korea(BAK) founded
2000. 7 Korea Bio-venture Association(KOBIOVEN) founded
2008.11 BAK, KOBIOVEN and KBRA merged into KoreaBIO
Korea Bio Industry 3
Korea Biotechnology Industry Organization(KoreaBIO)
• Korea Bio Park consist of 3 buildings with 22 Companies.
• 2005-2011(6 years)
• 2006. 5 – Land supply for Pangyo Techno Valley was approved.
• Hand in Business plan named ‘Korea Bio Park Project’
• Move in May 2011
Korea Bio Park
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Korea Biotechnology Industry Organization
Member companies
Most of the top pharmaceutical companies
Most of 50 bio-technology companies listed on the Kosdaq
They have worked in bio-technology, pharmaceutical, medical device et al
(Total : about 300 member companies)
<Top 10 Pharm Companies in Korea>
Rank Name Sales(KRW bil.)
1 Yuhan Pharm 1,018
2 Green Cross 975
3 Daewoong Pharma 727
4 Hanmi Pharm 582
5 Dong A ST 568
6 Chong Kun Dang 544
7 Kwangdong 513
8 Jeil Pharm 413
9 JW Choongwae 413
10 LG Life Science 412
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Korea Biotechnology Industry Organization
MOU with China BPBC VIP China Visit
MOU with China science technology cluster, ChangPyungWonin ChungKwanCun nearby Beijing
Korea Bio Industry 7
Korea Biotechnology Industry Organization
MOU with Australia AusBiotech
Business matching with Australia and
Korea companies April in Bio Korea
2015 period.
ContentsI. Government
II. Industry
III. Hospital
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The History of Biotechnology in Korea
Year Content
1982 Foundation of the Genetic Engineers Association composed of seventeen preeminent professors and scientists from the field
1983 Enactment of the Genetic Engineering Support Act (currently Biotechnology Support Act)
1985 Foundation of the Korea Research Institute Bioscience and Biotechnology Foundation of the Korea Biotechnology Association (Now known as the Korean Society for Biotechnology and Bioengineering)
1989 Establishment of the Bioindustry Development Strategy and the Korean Society forMolecular Biology (Now known as the Korean Society for Molecular and Cellular Biology)
1991 Establishment of the Korea Bioindustry Association
1994 Establishment of the 1st Basic Plan for Biotechnology Support, Biotech 2000
1995 Long-term Vision for the Bioindustry Development (currently the Ministry of Trade, Industry & Energy)
1997 Legislation of the Guidelines on Genetic Recombination Experiments (The Ministry of Health & Welfare)-Foundation of the Biotechnology Safety and Ethics Association
1998 Enactment of the Brain Research Promotion Act; foundation of the KAIST Brain Science Research Center and the Bio Venture Company Support Center
1999 Establishment of the Basic Plan for Brain Research Promotion (valid 1998-2007)The 21st Century Frontier R&D Project Plan (currently the Ministry of Education)
2000 Designation of the Bioindustry as one of the government’s key industries for development; establishment of the BioindustryDevelopment Plan (currently the Ministry of Trade,Industry & Energy)
2001 Enactment of the Trans-boundary Movement, Etc. of Living Modified Organisms Act; Designation of biotechnology as core strategic technology in creating new industries in the 21st century under the Basic Plan for Science and Technology
Promotion (2002-2006); foundation of Next Generation Core Environmental Technology Development Project(Ministry of Environment)
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The History of Biotechnology in Korea
Year Content
2002 Establishment of vision and Strategy for Bioindustry development, biocluster projects, long and mid-term health and medical treatment development plan
2003 Publication of the first issue of Biotechnology journal
2004 Introduction of genetic recombination technology in Korea
2005 Formation of Biotechnology R&D Strategy (Office of Science and Technology Innovation, currently Ministry of Science, ICT and Future Planning) and pan-governmental drug development strategy (Office of Science and Technology Innovation,
currently Ministry of Science, ICT and Future Planning)
2006 Establishment of the 2nd Basic Plan for Biotechnology Support, Bio Vision 2016
2007 Establishment of the 2nd Basic Plan for Brain Research Promotion (2008-2017); proclamation of the Year of Biotechnology; establishment of the National Bio Resources Master Plan; opening of the National Institute of Biological
Resources (currently Ministry of Environment)
2008 Bioindustry Statistics (KS) authorized; Launch of Industrialization of Agricultural Biotechnology Support Project (Ministry of Agriculture, Food and Rural Affairs); Establishment of Science and Technologies, Basic Plan for Science and Technology
or 577 Initiatives; Launch of Korea Bio Economy Forum (currently Ministry of Trade,Industry & Energy)
2009 Enactment of the Act on the Securement, Management and Utilization of Biological Resources; Enactment of the Act on Support of Science and Technology for Food, Agriculture, and Fisheries; designation of seventeen industries in three
sectors as ‘new growth energy industries’ under the New Growth Engine Vision and Development Strategy; Launch of the HT Forum (currently Ministry of Health and Welfare)
2010 Publication of the NBIC National Technological Convergence Master PlanFoundation of Korea Bio-venture Association(KOBIOVEN)
2011 Enactment of the Special Act on Fostering and Support of pharmaceutical Industry; reformation of the National Science & Technology Commission as an administrative body under the direct instructions of the president
2012 Establishment of revision of the 2nd Basic Plan for Biotechnology Support (2012-2016)
2013 Reorganization of the National Science & Technology Commission as the National Science and Technology Council
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Government Vision and R&D Investment
Net Investment in Biotechnology R&D
GDP to R&D rate is 4.36% (0.31% increase year-on-year)
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Status of Bio Similar
Company Original Products Progress Status
Celltrion Remicade US NDA in middle of 2015, Approval of MFDSApproval in EU, Canada, Japan
Herceptin Approval of MFDS
Rituxan clinical phase 3 in progress
Enbrel Pre-clinical in progress
Enbitux Pre-clinical in progress
Synagis, Humira, Avastin R&D
Samsung Bioepis Enbrel US NDA in 2015-2016, Europe NDA in 2016
Remicade, Humira, Herceptin, Lantus
clinical phase 3 in progress
Aprogen Remicade Japan clinical phase 3 in progressJapan NDA in late of 2015
Aranesp, Rituxan Document sumit for NDA
LG life science Enbrel Korean clinical phase 1 in progress
DaewoongPharma
Enbrel Korean clinical phase 1 in progress
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Government Regulation
Domestic Pharmaceuticals Trends
Source : Dataguide, KDB Daewoo Security
Korean Domestic Market is Government Regulation’s Function
0
100
200
300
400
500
600
00 01 02 03 04 05 06 07 08 09 10 11 12 13
(100= 2000.1.1)
2006.11Drug price reasonable
Policy
2010.5Rebate
dual punishment system
2012.4Drug price
Reneual
2014.2Market real price
system (Scheduled)
Reference price system(TBD)
2008Global
Recession
- It’s been accepted trends before Global Cooperation
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Bio-tech Company Global Activities
Global pharmaceuticals
Bio-tech company
Laboratory
Unmet needs
License outor
M&A
Source: KDB Daewoo Security
Value ChainType Korean Golobal
M&A SD Inverness Medical
Innovations(USA)
Co-
operation
Binex Nichi-Iko Pharmaceutical
(Japan)
Joint
Venture
Donga ST
Pharm.
Meiji Seika Pharma
(Japan)
Genexine Ajinomoto(Japan)
ILKO(Turkey)
Tech.
Transfer
Meditox Allergan(USA)
Pharmabcine 3SBio(China)
Triphase(USA)
Hanmi Pharm. Lilly(USA)
Altegen Cristalia(Brasil)
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Top Korean Conglomerates invest into Bio Industry
Investment in Bio industry
Global Pharmaceuticals Promoting Fund
1st Global Pharmaceuticals Promoting Fund 100 mil $ (INTERVEST Venture Capital)
2nd Global Pharmaceuticals Promoting Fund 135 mil $ (Korea Investment Partners)
Seoul Global Bio-Medical Fund for New growth Industry
70 mil $ (Hanwha Investment)
Bio-Pharmaceutical Fund 10-30 mil $ (Hanwha Investment) made about 20 funds
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Giant Going into Medical device
Samsung investment 2 billion in medical device (acquired Medison)
SK investment in Nanoentech
Biological drugs
2 billion investment in biosimilar (Samsung Biologics with Qunitiles)
Celltrion getting 200 million investment from Temasek
LG and Hanwha is also, investing in biosimilars
Regenerative medicine
Smart Healthcare
Stem-cell research, later state clinical development
Feasibility study undergoing with 10,000 diabetic patients
Recent Highlights in Korea
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Cure Diagnosis Care & Prevention
Molecular DiagnosisMedical Devices
Pharmaceuticals CompanyDNA sequencing
Medical service effectiveness improvement opportunity cost reduction
Healthcare Service Trends
Technology Trends
Small Molecular Protein -mAB DNA, RNACell
No mere New Blockbuster Personalized Medicine, incurable disease cure
Early Commercialization stage
Novel Therapeutics' R&D stageBio-tech Research Trends
Korea Bio Industry 22
Samsung Medical Center
Source : Samsung Medical Center BMCC, KoreaBIO
Connect
Open Innovation for Medical Devices
(Medical Doctor, Investor, Counselor)
Education
Conference
Seminar
News letter
Consulting
On Demand Consulting
In Depth Consulting
- Government Infra Project- Benchmark “UCSD CONNECT”
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Asan Medical Center
Source : Asan Medical Center, KoreaBIO
Guest House for company
11 companies
PRISM
Non-Clinical R&D Support System
Cancer12% of Korean Cancer Patients
Personalized Cancer Medicine Center
CJ, Samyang, DNA Links, Crystalgenomics,
Meta Bio, Neomics, Genolution
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Nationals Cancer Center
Source : National Canter Center, KoreaBIO
0.T.T.
(Office of Technology
Transfer)
R & D
IP
Technology Tansfer