ISTNsmall technology for big marketsTM

Industrial Science & Technology Network

ISTN Nanotechnology Development

September 22, 2005

September 2005 ISTN Inc.

ISTN Inc. - An Introduction

A small Contract Research company of 15 employees, including 9 Ph. D. research scientists

Has superior knowledge and experience in water treatment, foaming insulation, adhesives, optical electronics, and biotechnology fields

Located in York, PA with office, laboratories, and many analytical instruments

Ongoing Joint-Venture and Projects in China, Taiwan, Korea, and other countries

Collaboration with many Universities and Institutes in the United States and overseas

September 2005 ISTN Inc.

ISTN – Early Mover in Nanotechnology Founded in 1997 by Dr. Arthur J. Yang

Former Insulation Research Director at Armstrong ATP grant for Nanopore Thermal Insulation – 1992

Develop organic-inorganic nanocomposites Functionalized silica materials (sol-gel chemistry) Polymer-metal composites

Industrial Products

Opto-Electronics Biotechnology

September 2005 ISTN Inc.

CSMG – Nanopore Reactive Adsorbent Selective Adsorption –

significantly enhances reaction kinetics.

High Capacity – nanopores, surface regeneration, selectivity

Flexible Platform –

surface ligand groups can be designed to accomplish variety of functions, (adsorption, separation, catalysis, etc.)

Integration – adsorption, catalysis, and reaction combined in one product

Platform Technology with Tremendous Commercial Potential

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SH S

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Hg+2

Hg+2Na+

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Iron

Silica

September 2005 ISTN Inc.

Nanopore Enhanced Enzyme Device

Key Properties Immobilized enzyme can be reused

many times Reaction can occur in continuous flow

mode instead of batch mode Product can be separated from

reactants during reaction, which promotes reaction rate

Reaction and separation done in one continuous flow operation

Column can be regenerated by effluent wash after saturation

Process is suitable for large-scale operation and can be fully automated

Encapsulation of Biological Entity With

Silica

September 2005 ISTN Inc.

Optical Coatings

Wet chemistry process, no vacuum needed

Sol-gel process to prepare optical transparent coatings

Anti-glare/anti-reflective or high reflective coatings

Low cost process Ready to apply to large

surfaces Application including: lenses,

solar panel, display screens, architecture glasses, protection films, etc.

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R1

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R2R3

R1

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R2R3

September 2005 ISTN Inc.

Nanotechnology for Drug Delivery

Silica-Chitosan Composite Funding: Phase I SBIR (2004) Applying for Phase II

Key Properties Controlled release for ulcer

treatment. Maximizes efficacy while minimizing side effects

Silica-Chitosan composite has increased residence time in stomach (highly acidic).

Entangled network of chitosan and silica molecules maintain structural integrity

Low MW Protamine (LMWP) Funding: Phase I STTR, Phase II

SBIR (2002) Pursuing IND from FDA

Key Properties Drug use for non-toxic heparin

neutralization which can also be used for drug and gene delivery

Able to translocate through cell membranes (structural similarities to HIV-TAT protein)

CSMG technology utalized to optimize thermolysin immobilization for continuous production of LMWP

Collaboration with University of Michigan’s College of Pharmacy

September 2005 ISTN Inc.

Flexible Commercialization Strategy

Objective Advantage

Customer and end-user relationship to test CSMG for novel applications

Sales/marketing partnerships to complement own direct sales force

Joint development agreements with large corporations

Transactions to utilize CSMG for specific applications

Joint venture / spin-off with corporate or institutional investor

Significant investor involvement in strategic and management decisions

Strategic Alliances

Licensing

New Company