Formulation Benefits & Guidelines

Using ISP Captivates™ GL

Microencapsulation:

JetCutter™ Technology

Oct. 30 2008

Agenda

A brief intro to JetCutter™ technology

Formulation guidelines

Prototype formulations

Summary

What is JetCutter™ technology?

These are spherical solid particles made from

different polymers such as alginate, carrageenan

or chitosan

Gelled using techniques such as ionic exchange,

pH-shift and temperature change

Typically contain 3 – 5% polymer

The polymers form a hydrogel matrix throughout

the complete bead that can trap insoluble

powders, oils and water soluble actives

JetCutter™ variables

Color- standard colors, pearlescent, fluorescent and

luminescent

- Customize to your Pantone color

Uniform spherical size

- from 250µm to 3000µm depending on the viscosity

of encapsulation mix

Hydrogel type- different hydrogels such as alginate, carrageenan

and/or chitosan are used

JetCutter™ variables

Bead composition

- pigments, clays, oils, insoluble vitamins, proteins,

amino acids, abrasive particles (e.g. micronized

polethylene, silica)

Microbeads are supplied as a preserved

aqueous suspension

Formulation benefits

Dynamic color release systemSpecifically in surfactant systems

Smooth color rub-out in leave-on applications

Enhance moisturizationBeads can incorporate pockets of creams/lotions

Provide texture & sensory signalImpart distinct rub-out qualities

Exciting visual Appeal

Formulation Guidelines –

ISP Captivates™ GL

Encapsulation in Hydrogels

Material to be encapsulated is mixed into the polymer solution prior to bead formation

+

Alginate beads

Alginates Beads are made by ionic interaction with Ca++ ions

Ca++ ions acts as a cross-linker with the alginate. The level

of Ca++ ions (2.0% CaCl2) results in hard, stable beads

Alginate beads

Monovalent ions in the personal care formulation interact and exchange with the Ca++. This leads to softening of the

beads

Many of ISP’s alginate beads are made with a small

amount of Carrageenan or Gellan-gum. As the alginate portion is softened by the above mechanism, the

carrageenan or gellan-gum can hold the bead together

Alginate beads

Beads will soften considerably and may be unstable in the

presence of any material that will sequester calcium (e.g.

Stabilize and other Gantrez polymers)

Type of thickener

Amount of bead

For ex. 3.0% beads use level in formulation will result in

0.06% CaCl2

Carrageenan beads

Two types of Carrageenan are usedKappa stabilized with K+, Iota with Ca++

Beads will dissolve in deionized water. The

addition of electrolyte to the formulation

is essential to keep them stableBeads are stable when

NaCl solution level is 3.0% and above

CaCl2 solution level is 0.75% and above

Carageenan beads

Suitable for all anionic/nonionic surfactant

formulations

Will soften in warm water giving no residue in

bath/shower products

Works between pH 3 - 12

Hydrogel blends

Combines the properties of alginate-

carrageenan hydrogelProvides a strong bead that is easy to formulate

with, but softens as the alginate gel strength is

reduced

The carrageenan in the bead provides a bead

with desired rub-out resistance

Formulating with Alginate-Carrageenan bead

GL 7158 (Alginate-Carrageenan bead)1.0% Sodium Alginate + 0.5% Carrageenan + 25.0%

Ultramarine blue

Impact of ingredients on bead:3.0% bead in water

3.0% bead tested with varying levels of surfactant

3.0% bead tested with thickeners

3.0% bead in water

GL 7158 in water

3.0% bead in surfactant

GL 7158 in 1.0% ALS solution + 0.1% CaCl2 GL 7158 in 5.0% ALS solution + 0.1% CaCl2

3.0% bead in surfactant

GL 7158 in 10.0% ALS solution + 0.1% CaCl2 GL 7158 in 30.0% ALS solution + 0.1% CaCl2

3.0% bead in thickener

GL 7158 + 8.0% Acrylates Copolymer GL 7158 + 1.0% Carbomer

3.0% bead in thickener

GL 7158 + 1.0% Hydroxypropyl Guar

GL 7158 + 3.0% PVP

Chitosan beads

Chitosan – derived from shell-fish

Beads are chemically stable in most formulations

and rarely soften or dissolveBeads are hard enough, so can be used as scrub particles

Incorporates pockets of creams/lotions

Beads break more like a capsule and are usually soft

Can contain lotions, oils and butters

Stable over broad pH range

ISP Captivates™ GL: General guidelines

The appropriate hydrogel system needs to be selected for each formulation

Stability testing is essential

Do not rinse the beads before their introduction to the formulation due to their sensitivity to ionic force

Most beads will swell and soften after addition to the formulation but some will remain unchanged

ISP Captivates™ GL: General guidelines

Add using slow sweep agitation

High shear and high pressure pumping should be avoided where possible

Add beads at last stage of production, after

adding the fragrance and preservative

Pack as soon as possible after manufacture. This

is to preserve the original shape since softening

of the beads is common in most formulations

Prototype Formulations –

ISP Captivates™ GL

Color Burst Hand Soap

Ingredient %w/w

A Deionized Water 58.40

Acrylates / C10-30 Alkyl Acrylate

Crosspolymer

1.00

Glycerin 4.00

B Ammonium Laureth Sulfate 31.00

Triethanolamine 1.45

Calcium Chloride 0.15

C Germaben® II-E 1.00

ISP Captivates™ GL 7158 1.50

ISP Captivates™ GL 7181 1.50

Total 100.00

GL 7181: Yellow Hydrogel Beads:

Sodium Alginate + Carrageenan

matrix containing 20% pigment

GL 7158: Blue Hydrogel Beads:

Sodium Alginate + Carrageenan

matrix containing 25% pigment

Scrub & Sparkle Shower Gel

Ingredient %w/w

A Deionized Water 56.55

Acrylates / C10-30 Alkyl Acrylate

Crosspolymer

1.00

Glycerin 4.00

B Ammonium Laureth Sulfate 31.00

Triethanolamine 1.45

Cocoamidopropyl Betaine 3.00

C Germaben® II-E 1.00

ISP Captivates™ GL 7002 1.00

ISP Captivates™ HC 0008 1.00

Total 100.00

GL7002: Red Hydrogel model

particle ~800um Carrageenan

matrix coloured redHC0008: Clear Colorless

Coacervate Capsules ~500um

containing Dimethicone and glitter

Skin Toning Gel

Ingredient %w/w

A Deionized Water 66.91

Sodium Hydroxide (10% aq. soln) 0.18

UltraThix™ P-100 0.65

B Sodium Hydroxide (10% aq. soln) 1.41

C Lubrajel® II XD 2.00

D Liquid Germall® Plus 0.75

Calcium Sodium Borosilicate (and)

Titanium Dioxide (and) Tin Oxide

0.10

E ISP Captivates™ GL 7245 28.00

Total 100.00

GL7245: Foundation-based hydrogel:

Sodium Alginate + Carrageenan matrix with

titanium dioxide, pigments, emollient

Sanitizing Gel

Ingredient %w/w

A Deionized Water 41.50

Propylene Glycol 2.00

Triisopropanolamine 0.02

UltraThix™ P-100 0.50

B SD Alcohol 40-B 55.00

Triisopropanolamine 0.48

C ISP Captivates™ GL 7144 0.50

Total 100.00

GL 7144: Green Hydrogel Beads:

Sodium Alginate + Chitosan matrix

containing 20% Soya Oil, waxes, V-E,

pigment

Applications

Creams

Lotions

Gels

Shampoos

Conditioners

Body washes

Liquid hand soaps

Foundations

Sample colors

GL 7145GL 7223

GL 7197

GL 7254 GL 7198

Sample colors

GL 7249

Sample colors: Polymer composition

GL 7145 2.8% Sodium Alginate

GL 7197 3.0% Sodium Alginate

GL 7198 1.8% Sodium Alginate

GL 7223, GL 7254 1.0% Sodium Alginate + 0.5%

Carrageenan

GL 7249 0.7% Sodium Alginate + 0.3%

Carrageenan

Summary –

ISP Captivates™ GL

Summary

JetCutterTM technology is a versatile tool for

hydrogel developmentBroad variety of (bio)polymers and other materials

used

ISP CaptivatesTM GL can incorporate ingredients

according to customers' requirementsHigh number of variables allows customization

Exciting new products can be created Color, texture and moisturization delivery

Summary

Alginate-based beadsCaCl2 levels in formulation should be considered

Carrageenan-based beadsElectrolyte balance is essential

Chitosan-based beadsFormulation pH is important

Contact

Your technical sales rep. for custom samples

www.ispcorp.com for webinar presentation

ISP technical labs for product design support

Thank you