INTRODUCTION TO AUTONOMIC PHARMACOLOGY: Part III Mechanism of neurotransmission at
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INTRODUCTION TO AUTONOMIC PHARMACOLOGY: Part III
Mechanism of neurotransmission atin the autonomic nervous system
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General Features of PeripheralAutonomic Neurotransmission
NT = Neurotransmitter
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General Features of PeripheralAutonomic Neurotransmission
Membrane Depolarization ofPre- or Postganglionic Fiber
Calcium Entry intoVaricosity
Exocytosis of NTDiffusion of NT AcrossNeuroeffector Junction
or Synapse
Activation of NT Receptors
Depolarization of Postganglionic Fiber or Response of
Effector Cell
Nerve Impulse
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Sympathetic Postganglionic Fiber Effector Cell
Neuroeffector Junction
COMT
(Liver)
SUMMARY OF ADRENERGIC NEUROTRANSMISSSION
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Summary of Catecholamine BiosynthesisTyrosine
DOPA
Dopamine
Norepinephrine
Epinephrine
ADRENALGLAND
SYMPATHETICNERVE
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Parasympathetic/Sympathetic Preganglionic Fiber or
Parasympathetic Postganglionic Fiber
Neuroeffector Junction
Parasympathetic orSympathetic
Postganglionic Fiberor Effector Cell
SUMMARY OF CHOLINERGIC NEUROTRANSMISSSION
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COTRANSMISSION
Release of More Than OneNeurotransmitter from the Same
Nerve Terminal
Cotransmitter B
Synergistic or Opposite Actions
Cotransmitter A
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Types of Postsynaptic Synergism
Norepinephrine/NPY
Norepinephrine/ATP
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Example of Postsynaptic Synergism:(NPY enhances actions of NE)
NPY 10 nMNE
NE
Per
fusi
on P
ress
ure
(m
mH
g)
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Example of Postsynaptic Synergism:ATP mediates fast responseNE mediates slow responseControl
Prazosin
Prazosin +Suramin
Control
Suramin
Prazosin +Suramin
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Many Examples of NANC Neurotransmitters
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Many Examples of NANC Neurotransmitters
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MODULATION OF NEUROTRANSMISSION
Modulation of Neurotransmisson
Presynaptic/Prejunctional Modulation
Postsynaptic/Postjunctional
Modulation
Presynaptic/Prejunctional
InhibitionPresynaptic/Prejunctional
Facilitation
Postsynaptic/Postjunctional
InhibitionPostsynaptic/Postjunctional Facilitation
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MODULATION OF NEUROTRANSMISSION
From Nerve Terminal Being
Modulated(e.g.,
Autoinhibitory Feedback)
From Postsynaptic/Postjunctional
Site (e.g., Trans-synaptic/
Transjunctional Inhibitory Feedback)
From Nearby Nerve
Terminal (Cross-
talk)
From Remote Site via
Circulation(e.g., Renin
Release)
Sources of Modulators of
Neurotransmission
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Mechanisms of Neuromodulation
NE Ach
NE
Ang II+
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Mechanisms of Neuromodulation
Epi