INTRODUCTION TO AUTONOMIC PHARMACOLOGY: Part VI Interaction of drugs with the autonomic
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Transcript of INTRODUCTION TO AUTONOMIC PHARMACOLOGY: Part VI Interaction of drugs with the autonomic
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INTRODUCTION TO AUTONOMIC PHARMACOLOGY: Part VI
Interaction of drugs with the autonomic nervous system
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SYMPATHOMIMETICS: Drugs that facilitate or mimic some or all of the actions of
the sympathetic nervous system.
Direct Acting
Indirect Acting
Drugs that facilitate NE release
Drugs that block NE uptake-adrenergic agonists
-adrenergic agonists
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Ganglionic blocking
drugs
Centrally acting sympatholytics
NE depleting drugs
Drugs that inhibit NE synthesis
Adrenergicneuronal
blocking drugs
-adrenergicantagonists
-adrenergic antagonists
SYMPATHOLYTICS: Drugs that reduce or inhibit some or all of the actions of the
sympathetic nervous system.
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PARASYMPATHOMIMETICS (CHOLINOMIMETICS): Drugs that
facilitate or mimic some or all of the actions of the parasympathetic nervous system.
Muscarinic receptor agonists
Anticholinesterases
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PARASYMPATHOLYTICS (ANTICHOLINERGICS): Drugs that reduce
or inhibit some or all of the actions of the parasympathetic nervous system.
Muscarinic receptor
antagonistsGanglionic blocking
drugs
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Predicting Responses of Drugs that
Interact with the Autonomic
Nervous System
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Baroreceptor Reflex
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Baroreceptor Reflex
BP(mmHg)
SNA(Units)
PSNA(Units)
HR(bpm)
Time (minutes)
Phenylephrine Histamine
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Predicting Responses
1 & 2
1, 2, 1 & 2
1, 1 & 2
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ACH (2 g)
ACH (5 mg)
ACH (50 g)
ACH (50 g)
ACH (5 mg)
Heart Rate Blood Pressure
(Atropine: Muscarinic Receptor Antagonist)
(Hexamethonium: Neuronal Nicotinic Receptor Antagonist)