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Transcript of '@International catecholamine symposium ; 4 (Pacific Grove ... · Catecholamines: Basicand...
Catecholamines:
Basic and
Clinical Frontiers
Volume Two
Proceedings of the Fourth International Catecholamine SymposiumPacific Grove, California, September 17-22, 1978
Edited by
Earl Usdin*Psychopharmacology Research Branch
National Institute of Mental Health
Rockville, Maryland
Irwin J. Kopin*Laboratory of Clinical Science
National Institute of Mental Health
Bethesda, Maryland
Jack Barchas
Nancy Pritzker Laboratory
Department of PsychiatryStanford University School ofMedicine
Stanford, California
This book was edited by Drs. Usdin and Kopinjn their private
capacities. No official support or endorsement by the NIMH is
intended or should be inferred.
Pergamon Press
UNIVERSITATSBIBLIOTHEKHANNOVER
TECHNISCHE
INFORMATJONSB1BLIOTHEK
NEW YORK • OXFORD • TORONTO • SYDNEY • FRANKFURT • PARIS
TABLE OF CONTENTS
Volume II: Neuroregulator Interactions, Lesions and Histochemistry,
Clinical Aspects
Section J: Neuroregulator Interactions
Immunocytochemical Studies on Catecholamine Cell Systems with
Aspects on Relations to Putative Peptide Transmitters (TomcU Hoki,eZ£,KjoIZ Fttxe, Me.ne.fe Goldstein, Olli Johamion, Ake. lju.ngda.kt, .Jan
LundbeAg and MaJuannt Schnltzbtnq)'
1007
Interactions of Enkephalinergic and Catecolaminergic Neurons
in CNS and Periphery (E. Coita, A. VI G-UdJU.0, W. FwJUtss., J. Hong
and H.-Y.T. Yang) 1020
A Review of Some of the Technical Problems Associated with
the Analysis of Neurotransmitter Localization and Interactions
in the Central Nervous System (N. WelneA., ?.K. Nakant and J.K.
Stzphzni) 1026
Studies on GABA-Monoamlne and GABA-Endorphin Interactions
(M. PeAez de la. Moao., K. r~uxt, K. AndeMion, T. Hdk&ult, A.
Ljangdaht, L. VoManl and R. Tapia) 1032
Opiate Receptor Stimulation Blocks the Activation of Striatal
Tyrosine Hydroxylase (TH) Induced by Haloperidol (A. Guldottl,F. \koKonl, K. Gait and K. Kumakita) 1035
Catecholamine Mechanisms: Interaction with g-EndorphinInduced Seizures [Sttven J. Htn>vLki>e.n and Floyd E. Bloom) 1038
Effects of Opiates on Nigrostriatal Dopaminergic Activity:
Electrophysiological and Behavioral Analyses [Agu. Vojdi, LoiuAe. A.
Veltiald and Vofwtky W. GallageA) 1041
Ultrastructural Evidence for a Synaptic Relation Between
Catecholaminergic and Peptidergic Neurons (l/.M. Vickol, T.H. Joh,
D.J. ReXi, S.E. Leeiwi and R.J. HilloA) 1044
g-Endorphin and Met-Enkephalln Induced Changes in Amine Turn¬
over in Discrete DA Nerve Terminal Systems of the Neostriatum and
the Limbic Forebrain {RobeAt Sc.hfian.tz, Kjell Ftixe, KuAt AndtLM&on
and LoudMz FeAland) 1047
A Search for Neurochemical Mechanisms Mediating Analgesia
Produced by Stimulation of the Nucleus Locus Coeruleus [He.nah.2m
Szgal) 1050
Interaction Among Enkephalinergic and Dopaminergic Systems
in Striatum and Limbic Forebrain (M. T/tabuccki, A. Poll, G.C.
Tonon and P.F. Spano] 1053
Enkephalin and Endorphin: Catecholamine Interactions [Stanliy
J. Watson, C.W. TUchand, R.0. ClaAaneMo and Jack V. BaAcdai) . . . 1056
Acetylcholinesterase is Synthesized and Transported by Dopamine
Neurons in Pars Compacta of the Substantia Nigra: Functional
Significance and Histochemical Correlations on the Same Brain
Section [lahhy L. ButakeA and Raymond MaJichand) 1059
V
FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM
Regulation of Hippocatnpal Cholinergic Neurons by DopaminergicSynapses in Septum [V.L. Ckznzy, S.E. Robtmon, V. Halthz-Sin.zm>izn,P.L. Wood and E. Co&ta) 1062
Adenylate Cyclase-Coupled Dopamine Receptors in Parkinson'sDisease [Maiato ShA.bu.ya and Olzh HoAnyktzwtaz) 1065
GABA-Mediated Regulation of Dopaminergic Neurons [K.G. Lloydand P. iilonmi) 1068
Effect of Electrical Stimulation of the Substantia Nigra and
A1 Area on the Turnover Rate of GABA (TRGABA) and HVA Content in
N. Caudatus and N. Accumbens (E. PeAalta ancTE. Coita) 1071
Interactions Between Biogenic Amines and Acetylcholine in the
Cerebral Cortex [T.A. ReadeA, J. do. Champlain and H.H. Jaipzn). . . 1074
The Regulation of Hlppocampal Cholinergic Neurons by
Noradrenergic Mechanisms [S.E. RobtrUOn, V.L. Chznty and E. COAta.) .1077
Interaction of GABA-ergic and Dopaminergic Systems in the
Caudate Nucleus of the Rat [Johannzi C. Stoo^ and Aniz H. MuXdeA). . 1080
Opiate Receptors Localized Presynaptically on Dopaminergicand Noradrenergic Neurons in Brain: Relevance to Tolerance and
Dependence to Opioids [Jzan-CkaAlzi SzhwaAtz, SopkLz de la Baumz,Cath.eAA.ne. Llon.zn&, GUlu Ratty and Hitznz VoULaAd] 1083
Peptide Effects on Mammalian and Invertebrate Dopamine (DA)
Neurons (W. LizhtznitzlgzA, F. Manned and V. Fztlx) 1086
The Interaction of Neuropeptides with Brain Catecholamines
[VlAk H.G. Vzutzzg) 1089
Enkephaline Interaction with Dopaminergic System in Rat CNS
[SeAg-io AlgznJL, AdAJxma Con&olaziom, Gabilzlla CatdeAtnl and
vin0 LOmiL&CJ-O) ^'^•^•,^\\..^ 1092
Microinjections of Opiate Agonists and Antagonists in the Area
of the Locus Coeruleus in Cats. Effects on Behavior (P.A.M. van
Vongzn and A.R. CooJU) 1095
Effects of a Nigral Application of Substance P and of an Anti-
Substance P Serum on Dopamine Release From Dendrites and Nerve
Terminals of the Nigrostriatal Dopaminergic Neurons in the Cat [AndAZCheAamy% RobeAt ULchzlot, Andul Hlzoullon, Vtncznt Lzv-LeZ and BeAnaAd
KzAdelhuz) 1098
Infusion of Substance P into Rat Substantia Nigra Increases
Dopamine Metabolism in the Striatum [PztZA C. WaldrnzieA, RogeA Kam
and KuAt Stocklin) 1101
Dopamine-Serotonin Interactions in the Nigro-Striatal Feed¬
back Loop [PzteA C. Waldmttzu, RogeA Kam and LauAznt MattAz) .... 1104
Effect of 5-Hydroxytryptophan on Brain Levels of Monoamines
and Dopamine Metabolite DOPAC [Guy M. EveAztt) 1107
A Morphological and Biochemical Dissociation Between Dopamineand Serotonin in Cat Brain (AndA.ee C. RobeAgz) 1110
Retrograde Transport of Serotonin in Central MonoaminerglcNeurons (P. BoblllizA, L. LtgeA, S. Atanzda, C. Font and J.F. Pujol] 1113
Serotonergic Involvement in the Regulation of Striatal Dopamine
Synthesis [Ronald KuczzmkA.) 1116
FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM Vii
Interactions Between Noradrenergic and Cholinergic Systems in
the Brain (f/.C. FiblgeA and S.T. Ma&on) 1119
Physostigmine Induced Alterations of Dopamine Metabolites in
CSF of Normal Subjects [Kenneth L. Vavii, Kym F. FauU., Lzo E. HolliiteA,Jack V. BaAchaj, and Philip A. BeAgeA] 1122
Role of Striatonigral Pathway and GABA Systems in Methamphetamine-Induced Depression of Striatal Tyrosine Hydroxylase Activity[Jamu ill. Glbb and Adalu J. Hotzhki&i) 1125
Striatal Dopamine Release Induced by the Intranigral Perfusion
of GABAergic Agonists in the Conscious Rat [GAzgoKy E. UaAtin, NanL. Papp, A. BoAbaAa P&luzgeA and Vzan R. Haabnich) 1128
Effects of Gammahydroxybutyric Acid on Dopamine Mechanisms and
Sleep [G. Stock, A. StzigeA, P. Kummzn. and K..H. SckloA) 1131
Altered Brain Dopamine Metabolism: An J[B. Vivo Comparison of
the Effects of Amphetamine and Prostaglandins (S.B. SpaAbz/i, J.A.Nizl&zn and L.H. FoMom)
, 1134
Microtubules Regulate Catecholamine and Prostaglandin E.
Function (Rab-i. Simantov and Lzo Sachi) 1137
Role of Catecholamine and Vasopressin Release in the TRH-
Induced Vasopressor Response (A. Honita, M.A. CaAlno and R.E.
islzitzman) 1140
A New Effect of Thyroliberin (TRH): Induction of Hyper¬
glycemia by Epinephrine Release (H. Kauaz and J. UozlleA) 1143
Adenosine - A Transsynaptic Modulator of NorepinephrineRelease? (BeAtt£ B. Fuzdholm and Pen. Hzdqvi&t) 1146
Purinergic Feedback Regulation of Catecholamine Release
[Chz Su) 1149
Angiohypotensin: A Selective Endogenous Inhibitor of Neuro¬
muscular Transmission in Vascular Smooth Muscle [Jozizi Knolt) . . . 1152
Thyroid Hormones and Adrenergic Neurotransmitters [Many B.
VAatman and Floy L. Cn.utc.mzld) 1155
The Role of Cyclic AMP on the Synthesis of Phenylalanine
Transaminase [Jzan Ckzn Skik and Yuen-Ling Chan) 1158
Phosphorylation of Contractile Proteins by Cyclic Nucleotide
Dependent and Independent Protein Kinases (Jome/5 T. Stull, Vavid
R. Manning, Chanlzi III. High, Pnimal dzLaneAollz and Vonald K.
Blumznthal) 1161
Histamine in the Heart and Spinal Cord of Hypertensive Rats
[J.P. CkalmeAA, P.R.C. Horn, J.C. Ptovii and M.J. ttiut) 1164
Serotonin Causes Accumulation of Cyclic AMP in Aplysia Heart
(P.R. Kzbabian, J.iil. Kzbabian and V.O. CaApzntZA) 1167
Allosteric Regulation of Brain Tryptophan Hydroxylase by
Submicromolar Calcium [Sazannz Knapp and Annold J. Mandzll) 1170
Plasma Melatonin in Manic-Depressive Illness [Al{n.zd J. Lwy,Thomai A. DIzhA, Philip ill. Gold and FtizdeAick K. Goodwin) 1173
A Vasopressin Hypothesis of Affective Illness: Preliminary
Findings (P.W. Gold, J. BallzngeA, A.P. lib, G. RobzAUon, R.M.
Po&t and F.K. Goodwin) 1176
The Pharmacology and Metabolism of Tyramine (A.A. Soulton and
A.V. Juohio) 1179
vili FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM
Dopamine Neuron Activity: Effect of SL 76 002, A New GABA
Mimetic Candidate (G. BaAtholini, B. Scatton, B. Zivkovic, P.
Ulonmi and K.G. Lloyd) 1182
Section K: Neuroendocrinological Processes
Central Catecholamine Systems and Neuroendocrine Regulation.Controllers of Anterior Pituitary Secretion [Kjzll FuX.Z, KuAt
AndeAi-ion, Luigi F. Agnati, Loui&z FeAland, Tomaj, Hoklzlt, Pztzn.
EneAoth, Jan-Afee Gabta&uon and Paul Skztt) 1187
Neuroendocrine Regulation - An Overview [Roland V. CiaAanzllo
and Richand Kvttnaniky) 1204
Estrogen Dependent Efflux of Endogenous Catecholamines from
the Hypothalamus In Vitro [Stzvzn M. Paul, Juliai AxzVwd and Phil
Skolnick) 1206
Effects of Peptides on Brain Monoamine Metabolism and on
Gross Behaviour in Rats (Toa MagnuMon, JeAui A. GaAcAa-Szvilla
and Anvid CanJU&on). 1209
Participation of Calmodulin in the Regulation of Dopamine
Receptors [Ingzbong Hanbauzn.). 1212
Catecholaminergic Control of Growth Hormone Secretion in Rats
[Kjzll Modigh, Paola BoHe. and Sta^an Edzn) 1215
Anterior Pituitary Dopamine Receptors and Prolactin Secretion
[RichaAd I. iileinzA, Michael J. CAonin, Czcilia V. Chzung, Nacia.
Fouaz, Bnicm R. Clank and Paul C. Goldsmith) 1218
Effects of Progesterone on the Noradrenergic System of Rabbit
Oviducts (J. BzimaA, H. LaAa, J. Sainz and H. ViveAOi) 1221
Intrahypophyseal Dopamine and Endocrine Events [MaAgoAzthzHolzbauzn. and V.F. Shanman) 1224
Regulation of Adrenoceptors by Thyroid Hormone [Shailzik P.
BcuaeAjee, HiAzndAa K. Skanma and Svaan E. Pointon) 1227
Regulation of Tuberoinfundibular Dopamine Neurons [Kznnzth E.
Mooaz, Kohei, Umzzu and Kzith T. VemoAz&t) 1230
Prolactin-Catecholamine Interactions and Puberty [ill. iiluttkz,K.G. Hohn, P. illittz and K.J. Honma) 1233
A New Strategy for the Selection of Dopamine Agonists and
Antagonists (J.R. Boi&AieA, F. LabAiz, M. Bzaulizu., T. Vi Paolo, C.
ObeAlandeA and C. EuvAaAd) 1236
Effect of Catecholamines in the Regulation of Melatonin Syn¬thesis in Mammalian and Avian Pineal Glands (Ttf.fe.eo Vzguchi) 1239
Endorphin Stimulation of Prolactin (PRL) Release: Its Re¬
lationship to Median Eminence DA Neurons (L. GAdndiion and A,
Guidotti) 1242
Role of Dopamine and Serotonin in the Morphine-Induced Release
of Prolactin [L. FeAland and F. LabAiz) .1245
Effects of Some New Dopamine Agonists on Prolactin Secretion
and Turning in 6-Hydroxydopamine Lesioned Rats (Jam&i A. Clzmzni
and E. BanAy Smal&tig) 1248
Relative Potencies of Dopamine Agonists on Prolactin Secretion
in Rats [H.V. MzltzeA, M. Simonovic, V.ill. NicholA, R.J. MillZA, J.
McVznmzd and V.S. Fang) 1251
FOURTH INTERNATIONALCATECHOLAMINE SYMPOSIUM ix
Serum Prolactin as an Indicator of Alterations in Brain DopamineSystems [IHaitzA A. Bn.own, Hatbam, Lai 'and GlzgoAy Bnown) 1254
Self Regulation of Prolactin Via Hypothalamic Catecholamines(Jome^ L. iloogt, LauAzncz Com. and Jay Lzvin] 1257
Hormonal Regulation of Dopamine Synthesis and Release in theMedial Basal Hypothalamus [Thomai C. illzitiall, Nancy A. PeAkini,i/ickiz TittznmaAy and Caxol Paul) 1260
Antagonism Between Estrogens and Dopamine at the AnteriorPituitary Level on Prolactin Secretion [Mickelz BzauLLzu., Thinz&Z VIPaolo, LouJj>z FeAland, Vincznt Raymond and FeAnand Labniz) 1263
Catecholamine Mechanisms in the Hormonal Regulation of
Sexual Behavior [Enic W.F.iH. Alton, Chanloitz H. iilnight and
Baxny J. EveAiXt), 1266
Antidopaminergic Effect of Estrogens at the Striatal Level
(C. EuvAand, F. Labniz and J.R. Boii&ieA) 1269
Involvement of Central Catecholamines in ReproductiveNeuroendocrine Processes [William R. CAOwlzy, Thomai L. O'Vonohuz
and Vavid M. Jacobowitz) 1272
Monoamine Regulation in Rat Endometrium and Brain Regions
During Early Pregnancy and Oestrous Cycle [V. CaiimiAi, C. QZmzdo,H. Poavzz, S. Poavzz and A. Piyckoyoi) 1275
Synthesizing Enzymes and Norepinephrine Turnover During Uterine
Adrenergic Nerve Degeneration and Regeneration Associated With
Normal Pregnancy (P. Aim, Ch. Owman, N.-O. Sj'obeJig and G. Thonbznt) 1278
Stimulation-Induced Release of Norepinephrine From Guinea-Pig
Ovary and Ovarian Ligament [Guiynnzth M. HandbeAg, Joctlyn W.
PznnziatheA and John A, Foaaoa) 1281
The Role of Central Noradrenergic and Dopaminergic Neurons
in the Control of TRH-TSH Secretion [Lucia Annanziato, Aldo
QpjattAonz, Gian^Aanco Vi Rznzo, Gznnano Schtttini and Paolo Pnzzioii)1284
Oral Contraceptive Thermogenesis and Urinary Amine (E, NE)Alterations [FAzdeAick P. luMpan) 1287
Hypothalamic-Pituitary Dopaminergic Function - Clinical
Studies (5. Lai and N.P.I/. NaiA) 1290
Defects in Brain Catecholamine Neurons in Patients with Growth
Hormone or Prolactin-Secreting Pituitary Tumours [Gltn R. Van Loon). I2?3
Hormonal Regulation of Monoamine Synthesis and Metabolism
[H. Poavzz, A.R. Bukhani, F. Bnion, V. CaiimiAi and S. Poavzz). . .1296
Section L: Lesions and Histochemistry
Distribution of Catecholamine-Containing Cell Bodies in the
Rabbit Hindbrain: A Study Using Formaldehyde-Glutaraldehyde Induced
Fluorescence [HI.U1. Blziiing, P.R.C. Howz and J.P. CkalmzAi). . . .1301
Similar Effects of Indoleamine and Phenylethylamine Hallu¬
cinogens on Dorsal and Median Raphe Neurons (MtfAfe A. GzyeA and
AAnold J. MandeU) 1304
Axonal Catecholamines Following Subdural Brain Trauma:
Examination Using an Improved SPG Hlstofluorescence Method (J.C.
dz la ToKAt) I307
FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM
The Relationship Between the Noradrenergic and Dopaminergic
Innervation of Medial Cortex in the Rat [John H. MoAniion, ReinhaAd
Gn.za.nna and Monk E. Moltivzn) 131°
The Topography of the Mesencephalic Dopamine Neuron Systems
[Jamzi H. Fallon and Robznt V. Mooaz) 1313
The Role of the Striatonigral Pathway in the Control of the
Substantia Nigra (M. GaAcia-Munoz and G.iD. AAbuthnott) 1316
Microfluorimetric and Neurochemical Studies on Dopamine
Neurons in the Central Nervous System - Effects of Haloperidol and
Sulpirid [Hakan HaWnan and Goita. Joniion) 1319
Afferents and Efferents of the Ventral Mesencephalic Teg-
mentum-AlO Region Studied by Using Tracing Techniques (H. Simon,M. Lz-Moal, L. StinuA and A. Calai) 1322
Integrated Morphology of Catecholamine and NeurophysinNeurons [John R. Sladzk, Jn..,Eanl A. ZimmeAman, J. Lobo Antunzi
and Thomai H. McNeill) 1325
Retrograde Axonal Transport of Nerve Growth Factor by Central
Monoaminergic Neurones of the Rat [Ian HzndAy and Suz Ebbott) . . . 1328
Histochemical and Biochemical Characterization of the Bullfrog
Lumbar Sympathetic Ganglia and Sciatic Nerves (I. Nagatiu, H. Kojima,V. Kondo, S. Inagaki and T. Nagat&u) 1330
Small, Intensely Fluorescent (SIF) Cells of the Human Sympathetic
Ganglia [Antti HeAvonzn, Paul! Hzlzn, Hannu Alho and Lai&z KanzAva) 1333
Regenerative Growth of Sympathetic Fibers into Rat Hippocampus
[Rzbzkah Lay and RobeAt V. Mooaz) 1336
Dopaminergic and Noradrenergic Neurons in Spinal Cord: Func¬
tional implications [John ill. CommiAiiong and Nonton H. NzlD. . . .1339
Sympathetic Innervation of the Spinal Cord [LauAa F. McNicholai,iilillLam R. Mantin, Jewell ill. Sloan and Mo&ako Nozaki) 1342
Catecholaminergic Autonomic Fibers in Human Male Pelvic/
Perineal Viscera (J.A. McConnell, Joz Wood and G.S. Bznion) .... 1345
Microspectrofluorimetric Mapping of the Formaldehyde Induced
Fluorescence (FIF) in the Rat Superior Cervical Ganglion [Hannu
Alho, PojjJLL Hzlzn and Antti HzAvonzn) 1348
Autoradiographic Localization of Monoamine Oxidase in Cardio¬
vascular Tissues [Michael C. Lowe) 1351
Non-Neuronal Localization of Catechol-O-Methyltransferase in
Brain [GaAy P. Kaplan, Boyd K. HaAtman and CynuA R. Cn.zveJU.ng). . .1354
Immunocytochemical Localization of Tyrosine Hydroxylase byPeroxidase Labeled Antibody Method [J.K. Stzphzni, P.R. VulLizt, P.K.
Nakanz and N. WzinzA) 1357
Observations on the Structure and Function of Catecholaminergic
Presynaptic Dendrites [Philip M. Gaovza, CkaAlzi J. illilion and StzphanJ. Young) 1360
Experimental Studies on the Origin of the Limbic Catecholamin¬
ergic Nerve Terminals [Mikloi Palkoviti) 1363
Continuities Between Mitochondria and Catecholamine-Storage
Vesicles [S.W. CoAmichazl, V.J. Smith) 1366
FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM XI
Ultrastructural Characterization of Monoamine Storage Com¬
partments After Permanganate Fixation [La&iz KaneAva and Antti
HeAvonzn) 1369
Ultrastructural Localization of Amine Stimulated Adenylate
Cyclase Activity (L. Rzchatdt, H. Hznvonzn and P. Panula) 1372
Transynaptic Regulation of Dopamine Synthesis After Raphe and
Striatal Lesions [Czcilio. T. Giombalvo and S. Robznt SnodgAaii) . .1375
Chemical and Biological Studies of 6-Hydroxydopamine Analogs
[Nzal Caitagnoli, CnanleA A. Ckavdanian and Vaiji KaAaihima) . . . 1378
Studies on the Mode of Action of 6-Hydroxydopamine and Re¬
lated Neurotoxins [Richand E. Heikkila) . , 1381
Role of Central Catecholaminergic Pathways in CirculatoryReflexes (P.I. Kon.nzA, J.A. Rzynoldion, J.R. OZivzn. and G.A.
Head) 1384
Analysis of the "Ventral Mesencephalic Tegmentum Syndrome"Possible Involvement of A10 Dopaminergic Neurons (L. StLnai, H.
Simon, 0. GaUoni and M. Lz Moat) 1387
Quantification of Catecholamine Terminals After 6-0H-DA. A
Correlated EM/FM Study [TeAzncz H. iilittiami, G.-H. Hwang and
Jzan Jew) 1390
Dopamine Sensitive Adenylate Cyclase in Substantia Nigra: Pos¬
sible Site of Action of Psychotropic Drugs (A. GAOppztti, G.
Racagni, M. PaAznti, A. Bugatti, A.M. Vi Giulio, A. Maggi and
F. Cattabzni) 1393
Plasticity of Mesolimbic Dopamine Neurons [G.M. Gilad and
J. Rtii) 1396
Adaptive Neurochemical Changes Following Destruction of Central
Dopamine-Containing Terminals [Mickazl J. ligmond and EdWOKd M.
StAickzn.) 1399
Selective Enhancement of the Effects of Haloperidol on a
Conditioned Avoidance Response by Lesions in the Parafascicular
Nucleus of the Rat [Svzn Ahlzniai) 1402
Extraneuronal Uptake of Isoprenaline into Guinea-Pig Trachealis
Smooth Muscle Cells as Studied by Fluorescence Histochemistry and
Quantitative Microphotometry [Stella R. O'Vonnzll and Lz&lzy J.
Buyan) 1405
Section M: Cardiovascular Mechanisms
Central Control of Blood Pressure [M. Palkovitz) 1411
Central Adrenergic Neurons in Spontaneous (Genetic) and Ex¬
perimental Hypertension [Juan M. SaavzdAa) 1416
Correlation Between CNS Angiotensinogen and Central Catecholamine
Pathways [Monton P. Pnintz, ClzatuM J. Waltu, John A. Lemicki and
JameA H. Fallon) 1419
Plasma Catecholamines and Direct Stimulation of Rat
Hypothalamus [C.L. Sun and I.J. Kopin) 1422
Role of the Medullary Adrenalin-Contajning Cells in Cardio¬
vascular Regulation [Mikloi Palkoviti, and Eva Mezei/l 1425
Adrenoreceptors of the Hypothalamus: Their Importance for the
Regulation of the Arterial Blood Pressure (A. Philippu., H. Viztl, U.
StAohl and V.T. Tiaic) 1428
xii FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM
The Role of Peripheral and Central Catecholamines in the
Regulation of Renin Secretion [William F. Ganong, Handin JoneA, Ja.
and Jonathan Chalztt) 1431
Role of Central Adrenergic Mechanisms in the Cardiovascular
Actions of Gamma-Hydroxybutyric Acid [Czdlia. Gornzi, MattA Hznning
and GuAtai Tiolin) 1434
Role of A2 Neurons in Control of Arterial Pressure in Rat
[Vavid ill. SnydeA, William T. Talman and Vonald J. RzU) 1437
On the Role of Noradrenaline and Adrenaline Neuron Systemsin Control of Central Cardiovascular Functions [PeA Bolmz, KjtllFuxz, Goita Joniion, Vztlzv Gantzn, Luigi Agnati, KuAt AndeAAAon,Hakan Hallman, Mznzk Gold&tzin and TomaA Hokizlt) 1440
Serum-Dopamine-Beta-Hydroxylase and Hypertension (F. LampAZcht) 1443
Mechanism of Antihypertensive Effect of Propranolol [Budh Vzv
Bhagat)'
1446
Catecholamine Synthesizing Enzymes in a New Strain of Spon¬
taneously Hypertensive Rats (B. Renatid, L. VznoAoy, M. Vincznt, S.
FouAniznz, J.F. Pujol and J. SaAiOAd) 1449
Deficient SIF Cell Dopamine Metabolism in Celiac Ganglion of
Young Spontaneously Hypertensive Rats (SHR) Before the Onset of
Hypertension [N.H. Nz&&, B.E. Lutold and F. KoAoum) 1452
Turnover of Hypothalamic Catecholamines in Spontaneously
Hypertensive Rats (C.C. Chiuzh and N.B. Thoa) 1455
Decreased Cardiac Beta-Adrenergic Receptors in Hypertensive
Rats [Elizabeth Woodcock, J.W. Fundzn. and C.I. Johmton) 1458
The Area Postrema and the Long-Term Regulation of Blood Pressure
(J.E. Szilagyi, K.B. Bhoinihan, K.L. Bomiza and C.F. FeAAaAto). . . 1461
Origin of Cardiovascular Effects of g Stimulating and Blocking
Drugs After Intracerebroventricular Injection [V. Poh.qu.zt, A.
Lindznbaum, Y. Cohzn and J. iUzpieAAz) . 1464
Relationship Between Ventromedullary Clonidine Sensitive
Area and Hypothalamus (RogeA Bloch, Joiianz Feldman, Paical BouAquztand Jean SchwaAtz] 1467
Hypotensive Effect Obtained by Application of Drugs to the
Ventral Surface of the Medulla: A Membrane Stabilising Mechanism?
[PoacoI BouAquzt, Jo&ianz Fzldman, RogeA Bloch and Jzan SchwaAtz) . 1470
Adrenergic Activation by Intracerebroventricular Administration
of Acetylcholine and 5-Hydroxytryptamine in Rats [Milovan K. KnAtic) 1473
Plasma and Tumor Catecholamines and Blood Pressure in 38 Patients
With Pheochromocytoma [William MuiA Manqzh.) 1476
Dopamine Excretion in Benign Pheochromocytoma [PzdAo A. S2AAO.no,BzatAiz Chavez-LaAa and GuAtavo Sa.nckzz-To.HAeA) 1479
y-Glutamyl Dopa and y-Glutamyl Dopamine as Kidney Specific
Pro-Drugs [ShzAwin Wilk, Hanuko Mizoguchi, Skexman Kup&tn. and
Manian Onlowiki) 1482
Central Catecholamines and Renovascular Hypertension in the
Rat (Jonn L. Rzid and MaAganzt A. Petty) 1485
High Pressure Liquid Chromatographic Analysis of EndogenousNorepinephrine (NE) Released From Canine Saphenous Veins [SheilaM. Muldoon, GeAtAudz M. Tycz, TkomaA P. MoyeA and Vuanz K. Roniz) .
1488
FOURTH INTERNATIONALCATECHOLAMINE SYMPOSIUM xiii
On the Pathophysiology of Cerebral Vasospasm: Transmitter
Changes in Perivascular Sympathetic Nerves, and Increased Pial
Artery Sensitivity to Norepinephrine and Serotonin [Ch. Oman,N.-Aa. SvzndqaaAd, L. Edvin&ion, T. Olin and Ck. Saklin) 1491
Dopaminergic Action on Brain Vessels [L. Edvin&ion, J.E.
Handzbo, J. McCulloch and Ch. Oman) 1494
Effects of^Diuretics and Diazoxide on Rat Brain Catecholamine
[HzctoA M. laldlvaA, BzatnXz Ckavzz and Ptdho SeAAano) 1497
Studies on 2-Methyl-3-(2,4,5-Trihydroxyphenyl)alanine, the
"6-Hydroxy Analog" of a-Methyldopa [Nzal CoAtagnoli, Vonald MiUAon,
Vaiji Kaha&hima and Kznnzth Melmon) 1500
Formation of a-Methylnorepinephrine in Rat Brain Stem and
Nucleus Tractus Solitarius After Acute Injection of a-Methyldopa(E.L Conway, B. JaAnott and W.J. Louii) 1503
Possible Direct Antagonism of Norepinephrine by Alpha Methyldopa
[illaltzn. M. BookzA, RichoAd ElliA, Aldzn FlztcheA, Lynnz G. Elliott
and William L, Wz&t) 1506
Dopamine-Beta-Hydroxylase of Plasma and Cerebrospinal Fluid
in Animal Stress and Human Hypertension [Luigi Cubeddu Ximznzz). .±509
Effect of Diuretic and Beta-Receptor Blocker Treatment on
Catecholamines [Bzatniz Ckavzz-Lana, GuAtavo Sanchez and Pzdno
SeAAano) 1512
Catecholamine Excretion by Spontaneous Hypertensive Rats on
Abrupt Withdrawal of Imidazoline Antihypertensives [V.B. ElliA,
W.J. Novick, Ja. and J.C. Wilkzn.) 1515
Vascular and Circulating Catecholamines in Diabetes and Hyper¬
tension [R.J. Hzad and B.A. Bznkowitz) 1518
The Dynamics of Catecholamine (CA) Metabolism in the Intact Human
Subject With Essential Hypertension (EH) [Stanlzy E. Gitlow, LauAa M.
Vzizdzic, Stanley W. Vzizdzic and liaac Roubex.nl 1521
Pulmonary Clearance of Circulating Catecholamines in Normal
Man and in Patients with Pulmonary Hypertension [Michael J. Solz,
Milutin Vnxibac, LzonaAd Schwantz, M. Naiin. HuAiain and Edwand F.
i/aughan-Nzil) 1524
Beta Receptor Desensitization in Congestive Heart Failure
(Jamei Thomai and BeAnan.d H. Manki) 1527
Interaction of Sodium (Na+) and Catecholamines (CA) on the
Control of Blood Pressure (K.B. Bnoinihan, J.E. Szilagyi, I. Maiaki
and CM. FzaaoaLo) 1530
Effect of Cardiac Presynaptic a-Adrenoceptor Stimulation
by Clonidine and its Antagonism by Phentolamlne and Prazosin on
Coronary Sinus Plasma Norepinephrine Overflow in Dogs (I. CaveAO,
A.G. Roach and B. Scatton) 1-533
Adrenergic and Cardiovascular Effects of Disulfiram in Man
[Nzal L. Bznowitz, Wattzn. K. Rogzu, MonxiA Se.fiambei.an and HangaAzt
WilAon)1536
Role of Dopamine and Norepinephrine in Carotid Body [Stzn
HzllAtAom and IngzboKg HanbauzA) 1539
Neurochemical Characterization of Pyroxamidin, A New
Antihypertensive Drug [ChniAtoph Szyinizd, HeAbzht Nowak and Hani-
PzteA WoU)1542
Xiv FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM
Section N: Neurological Disorders; Animal Models in Neurology
Current Approaches to Parkinsonism [Donald B. Calnz, AdAian
Wiltiami, ToomaA Eiklzn. and Hzikki Tznavainzn) 1547
Central Catecholamines and Neurologic Disease [Thomai N. ChaAz) 1554
Animal Models of Parkinson's Disease (M. GoldAtzin, J.Y. Lzw,S. NakamuAa, A.F. BattiAta and A. Lizbznman) 1559
Homovanillic Acid in Cerebrospinal Fluid and Carbon-11 Labelled
Dopa for the Detection of Cerebral Dopamine Processes _In Vivo
(J. Koh-l, M.L. Aizznitzin, S. RziHeAA, W. VaalbuAg and M.G.
Woldning) 1564
Oxygen-18 Use for Clinical Studies of Central Monoamine
Metabolism [T.N. ChaAz, A. NzophytidzA, V. Samuel, G. Szdvall and
C-G. Swahn) 1569
Monoamine Oxidase Activity in Fibroblasts From Control In¬
dividuals and Patients with Inherited Neurologic Diseases [SUAanB. EdzlAtzin, Mania R.C. Co&ta, Canmela M. CaAtiglionz and Xandna0. BAzakziield) 1572
Selective MAO Inhibition: A New Strategy in the Treatment of
Parkinson's Disease [J.V. ElAWoKth, 1/. GloveA and M. Sandlzn.) . . . . 1575
Neurotransmitters in Neurological Disorders of Childhood (I.J.
ButleA, W.E. Szi&znt, S.H. Koilow, R.M. CapAioli and H.S. SingzA). . 1578
Central Dopamine Metabolism in Human Paradoxical Sleep Dis¬
orders [JacqueA MouAet, BeAnaAd Rznaud and Robznt BloiA) 1581
Bromocriptine and Lergotrile in Parkinson Disease [AbnahamLizbznman, Elihu, Eitzy, Govindan Gopinathan, MaAfe. KupznAmitk and
Mznzk GoldAtzin) 1584
Catecholamine-Related Enzymes in the Brain of Parkinsonian
Patients (T. NagatAu, T. Koto, 1. Nagatiu, Y. Kondo, S. Inagaki, R.
Izafea and H. NaAabayoAki) 1587
Clinical Trials of Dopamine Receptor Sensitivity Modification
[MuAAay AlpeAt and Arnold J. Fnizdho^) 1590
Approaches to Study CA Turnovpr in Man Using In Vivo Deuterium
Labelling [BiAgitta SjoquiAt, E/tik AnggaAd, Enik WideAlbv and
Tommy LzwandeA) 1593
Apomorphine Prodrug Derivatives as Long-Acting Dopamine Re¬
ceptor Active Agents With Potential Clinical Utility [RoM J.
BaldzAiOAlni) 1596
The Antiparkinsonian Efficacy and Dopaminerphillic Propertiesof Ergot Alkaloids and of Tetrahydroisoquinolines [J.W. Lew, Y. Baba,S. NakamuAa, J. Engel and M. GoldAtzin) 1599
Assays of Monoamine Metabolites in CSF Samples From Control and
Narcoleptic Canines [Kym Fault, Antkun. S. Foatz, R. Baucz Holman,Patnicia J. AndeAAon and William C. Vzmznt) 1602
Characterization of [3H] Spiroperidol Binding in the Rat
Substantia Nigra [JzAemy I. Fizldi, TzhAy V. RziAinz, Nonman W. Pzdigoand HznAy I. ^amamuAa) 1605
An Animal Model for Huntington's Disease: Striatal Kainic
Acid Lesion [Joizph T. Coylz, Katklzzn BizieAz, Pztzn. CampochiaAo,Edythz London, Robznt Sckwancz and RobeAt Zaczefe) 1608
FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM XV
Duration of Drug-Induced Dyskinesias: A PharmacologicDistinction (BAu.ce I. Viamond and RichoAd L. BoniAon) 1611
An Animal Model of Pharmacological Therapy for Tardive
Dyskinesia Using Cholinergic Drugs (B.J. Sakakian, J.H. Gnowdon, W.R.
Millington, J.K. Boaa and R.J. Wuntman) 1614
Hypothalamic Hyperphagia Prevented by Destruction of Brain
Dopamine-Containing Neurons [John F. MaAAkall, Neil Rowland, SzymOUAM. Antelman and Vavid J. Edwandi) 1617
Neuropeptides and Other Dopamine Modulators in the Extra¬
pyramidal System [Bnucz I. Viamond, Rodznick Waltex, Gany S. Sudako^,Hznni S. Havdala, Gany A. OltmanA and Richand L. BoniAon) 1620
On the Mechanisms of Extrapyramidal Reactions Induced by
Neuroleptic Drugs (P. JznnzA, B.S. Mzldnum and C.V. Maudzn). . . .1623
CNS and Adrenal Gland Tyrosine Hydroxylase and the Influence
of Drug-Treatment on cAMP - Activity in Parkinson's Disease -
Human Post Mortem Studies (Pei:eA RizdzAeA, WaltkeA BiAkmzyeA, Wol&-VieteA RauAch, KuAt JzllingzA and Waltzx Vanizlczyk) 1625
A Comparison of the Effects of Chronic (Six Month) Administration
of Trifluoperazine and Thioridazine on Striatal Dopamine Function
in Rats [PztzA JznneA, Angela Clow, Andnzai Tkzodonou and C. Vavid
MaAidzn) 1628
Dopamine-Beta-Hydroxylase (DBH) and Pupillary Sympathetic
Activity in Idiopathic Torsion Dystonia (ITD) (A.P. KoACZljn, E.
Kahana, M. AltzA, R. Rabinowitz and M. Stnei&leA) 1631
Differential Clozapine Action on CNS Stimulants [EvzAztt H.
Eltinwood, Ja. and M. Manlynz Kilbzy) 1634
The Role of Scheduling in Amphetamine Hypersensitivity and
Tolerance (J.J. Fzigznbaum, W.J. isleinzn and H.L. Klawani) 1637
The Involvement of Monoaminergic Mechanisms in a Chemically-
Induced Hyperkinetic Syndrome in the Rat [Sabit Gabay) 1640
The Anticonvulsant Effect of Neuroleptics: Dependence on
Intact Noradrenergic Transmission (P. Wohmi and K.G. Lloyd) ....1643
Turnover and Excretion of VMA by Normal Volunteers and Patients
With Neural Crest Tumors (Etaood H. LaBhOAAZ) 1646
Brain Monoamines in Human Metabolic Encephalopathies [PetZA
Ri.zdzn.2A, KuAt JzllingeA and Wol^-VieteA RauAch) 1649
Immune Lesions of Central Noradrenergic Neurons Produced by
Dopamine 3-Hydroxylase (DBH) Antibodies (L.B. Gz^Zn, M. Coita, R.A.
RuAkand V. BnidgzA) 1652
Chronic Lead Exposure, Hyperactivity, and Alteration of Basal
and Catecholamine-Sensitive Adenylate Cyclase [Jamzi A. Nathanion) .1655
The Daily Fluctuation of Striatal Dopamine Content and d-
Amphetamine and Apomorphine Induced Stereotypic Behavior (P.M.
CaAvzy, W.J. WeinzA, P.A. NauAizda and Han.old L. Klawani) 1658
Section 0: Catecholamines and Behavior
Behavioral Neurochemistry—Expanding Perspectives (John Maddzn, 11/,
Glzn R. Elliott and Jack V. BoacMa) 1663
FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM
f
Age-Dependent Effects of 6-Hydroxydopamine on Locomotor
Activity in Rats (L. Szidzn, L. Eninoil, R. MacPhail, A. HzllzA
and F. E. MUIza) ,1669
Nonstriatal Dopamine Mechanisms in the Response to Repeated
D-Amphetamine Administration 1(0,5. Szgal, P.H. Kelly, G. Koob and
V.C.S. RobeAtA) 1672
Midbrain-Hypothalamic Catecholamine Projection Systems Mediating
Feeding Stimulation and Inhibition in the Rat [SaAak Fn.yeA Leibowitz)1675
Role of Forebrain Noradrenaline in Reward and Nonreward
[S. Owzn, M.R. BoaxdzA, J. Fzldoh, J.A. Gnay and M. Fillznz). . . .1678
Dopamine in Prefrontal Cortex of Rhesus Monkeys: Evidence for
A Role in Cognitive Function [Tkomai J. BAOzOiki, RogeA M. BAoWn,
JzhlAy Ptak and PatAicta S. Goldman) .... - .1681
Strain-Specific Mechanisms Regulating Adrenal Catecholamine
Synthesizing Enzymes During Repeated Immobilization Stress (Jon
M. Stolk, Vavid 0. Coopzn, Jz{iAzy H. HuAAt, MoJty Lzz LzdbztteA
and PztzA Q. HoaaAa ) 1684
Central Adrenergic Neurons as Mediators of Motivation and
Behavior-Evidence From the Specific Inhibition of PNMT (R.J. Katz,BaAbana B. TuAnzA, K.A. Roth and Bzxnand J. CaAAolt) 1687
The Role of Drugs Affecting Catecholamines on Shock-Elicited
Fighting in Rats [Mickazl H. ShzaAd) 1690
Evidence for the Involvement of a Brain Norepinephrine System
In Anxiety [V.E. Rzdmond, Ja., Y.H. Huang, J. Bauhi. and M.S. Gold). 1693
Social Setting: Effect on Physiological and Catecholamine
Parameters Elicited by Stress in the Rat (BuAA Eichzlman) 1696
Emergent Social Behavior and Hormonal Activity [Pathicia R.
BaAchai, William A. HahAiA, Pamela Angwin and Jack V. BaAchai). . .1699
The Effects of Amphetamine on Agonistic Behaviors in Non-
human Primates Suzannz HabzA, Philip A. BzAgzn. and PatAicia R.
BaAchai) 1702
Interaction of Alterations in Biogenic Amine Metabolism With
the Despair Response to Peer Separation in Rhesus Monkeys [GaAy W.
Kn.azmeA and William T. McKinnzy) 1705
The Role of Catecholamine in Hyperactivity Induced by Social
Isolation (R. Aihkznazi, I. SpziAeA and M. Wzinitock) 1708
Effect of Haloperidol (HAL) and Pimozide (PIM) on Pavlovian
Conditioning of the Rabbit Nictitating Membrane Response [MichaelP. Gimpl, liidoAz Gonmzzano and John A. HaAvzy) 1711
Hormonally-Mediated Noradrenergic Modulation of MemoryProcesses [Paul E. Gold 1714
Drug Induced Amnesias: Behavioral, Pharmacological and Neuro¬
chemical Studies [LzwiA S. FAzzdman and Vavid QuaAteAmain) 1717
The Interaction Between Brain Noradrenaline and the Pituitary-
Adrenal Axis in Avoidance Learning (5.0. OgAzn, K. Fuxz, C. KohlzA
and R. ScnwaAcz) 1720
Absence of Operant Behavioral Effect Following Specific Nor¬
adrenaline Lesions in the Rat Hippocampus [Vale, W. PzteAion andRichand Lavznty) 1723
FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM Xvi i
Blockade of the Different Enzymatic Steps in the Synthesis ofBrain Amines and Learning (CAR) in Hypobaric Hypoxic L.Dopa TreatedRats [FhanciA BoiimaAz, Moniquz Lz Poncin-Laiittz and Jzan Rapin) . . 1726
Activity of Central Catecholamine Systems and Feeding Be¬havior (Jan van dzn. Qugten and Jzi L. Slangzn) 1729
Monoamlnergic Function During Perinatal Life Under PerturbedFeeding Patterns and Undernutrition [S. Poavzz, G. limahan, A.
VzguzuAcz and H. Poavzz) 1732
Parallel Increase of Feeding and Hypothalamic Self-StimulationAfter Midbrain 6-Hydroxydopamine, But No Correlation of HyperphagiaWith Norepinephrine Depletion (Lu-c6 HzAnandzz and Bantlzy G. Hozbel). 1735
Roles of Catecholamines in Self-Stimulation and Other Behaviorsand Their Modifications by Drugs (5.W. Pnadkan and 5. Pnadhan). . . . 1738
Brain Stimulation Reward Sites Mapped in Relation to the
Ascending Catecholamine Systems [Vale CoAbztt and Roy A. llliAz). . . .1741
Dopamine Mediates the Rate-Increasing Effect of D-Amphetamineon Intracranial Self-Stimulation (A.G. Phiilipi and H.C. Fibigex) . .
1744
Models of Manic Behavior in Rats [3ohgz PeAzz-Cnazt, TkomaiVoutkitt and Walid Shzkim) 1747
Catecholamines and Sleep [EAnzit L. HaAtmann) 1750
The Role of the Mesolimbic Dopamine System in Locomotor
Activity, Eating and Drinking in the Rat [Gzongz F. Koob and TKzvohW. RobbiM) 1753
Behavioral Problems in Farm Animals [V.F. Shanman] 1756
Persistent Effects of Stress on Dopamine-Related Behaviors:
Clinical implications [SzymouA M. Antzlman and Alan J. EichleA). . . 1759
Decreased Activity and Increased Arborizations of the Rat
Mesocortical DA Neurons After Destruction of Ascending NE Bundles
(J.P. Taiiin, L. Lavizltz, G. Blanc, A.M. TklzhAy and B. BeAgeA). . .1762
Brain Dopamine and Sexual Behavior: Psychopharmacological and
Electrophysiological Evidence for an Antagonism Between Active and
Passive Components (A.R. Cagg-uiXa, 5.M. Antzlman, L.A. Chiodo andC.G. LintbeAAy) . 1765
The Type of MAO in the Nigrostriatal Dopaminergic Neurons of
the Rat [Bzntha Knoll, Julia Timan. and J. Knoll) 1768
Effect of Catecholamine Depletion on Alcohol Tolerance and De¬
pendence [Jzanzttz M. Wood and R. LaveAty) 1771
Recovery of Cocaine Self-Administration After 6-OHDA Lesion of
The N. Accumbens Correlates with Residual Dopamine Levels [V.C.S.
Robznti, M.E. CoAconan and H.C. Fibigzn.) 1774
Structure-Activity Relations in the Behavioral Effects of
Cocaine Derivatives [R.V. Spzalman and R.T. Kzlizkzn.) 1777
Lesions of the Meso-Cortico-Limbic Neurons in Rats: Dramatic
Increase of the Sensitivity to D-Amphetamine in a Self-Administration
Acquisition Paradigm [Mickzl Lz Moot, LouiA Stinui, Odilz Gai{oniand Hzavz Simon) 178°
Central Reward Systems and Substance Abuse (Conon Konnztikyand Ralph (J. Eipoiito) 1783
xviii FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM
Electroconvulsive Shock and Reserpine: Effects on Mono-
aminergic Receptor Binding in Rat Brain [Vzbha A. BeAgitAOm,SuAan TAziizn and Kznnzth J. Kzltan.) 1786
Plasma Catecholamines and Behavior of Rats During Stress
[Richand McCaxty and Inwin J. Kopin) 1789
Hypothesis for the Local Control of Norepinephrine Release
[Vavid M. Jacobowitz) 1792
Plasma Catecholamines Under Basal and Stressful Conditions
in Rat Strains Selectively Bred for Differences in Response to
stress [Vavid A. BlizaAd and Baucz Liang) 1795
In Vivo Release of Neurotransmitters Monitored by Continuous
Cerebral Ventricular Perfusion in the Rat: Effects of Alcohol
(R. Bhu.cz Holman, GAzg EgeA, Patnicia J. AndeAion and Kym Fault) . . 1798
Daily Fluctuation in Dopamine, Norepinephrine, Gamma-
Aminobutyric Acid and Melatonin Metabolism in the Non-Human Primate
(MoAfe J. Pzhlaw) 1801
Section P: Catecholamines and Psychiatric Disorders
A Possible Role for Dopamine in Schizophrenia and Manic-
Depressive Illness (A Review of Evidence) [William E. Bunnzy, Ja.,
Vanizl P. van Kammzn, Robznt M. Pobt and Blynn L. Ganland) 1807
Catecholamine Related Substances and Schizophrenia: A Review
[RichaAd Jed Wyatt, Llewellyn B. Big2low and J. Ckhiitian Gitlin). . 1820
Depression [John M. Vavii) 1826
Monoamine Metabolites in CSF in Psychiatric Disorders [PhilipA. BeAgeA, Kym Faull, Kenneth L. Vavii and Jack V. BaAchai) 1827
Pharmacologically Induced Bidirectional Change in Sensitivity
of Central Nervous System Dopamine Receptors (A.J. Fhizdho^, K.
Bonnet and H. Roizngantzn) 1830
Phenylethylamine (PEA) and Chronic Schizophrenia [RichaAd Jzd
Wyatt, Stzvzn G. Potkin, H. Elzanon. Cannon, Montz S. Buchibaum,VznniA L. MuAphy, VaAouk KaAoum, J. ChAiAtlan Gillin and Vavid M.
StoU) 1833
Dopamine Agonist Treatment of Schizophrenia (C.A. Tamminga,
M.H. SchaiieA, r'.C. Smith and John M. Vavii) 1836
Inhibition of Dopamine Synthesis in Chronic Schizophrenia:A Follow-Up Study (J. ChAiitian Gillin, Joel E. Kleinman, HznAy A.
NaAKallak, Llewellyn B. Bigzlow, Allan Rogo£, Vanizl Luchini, John
Canman, Vanizl WzinbeAgzA and RichaAd Jzd Wyatt) 1839
The Dopamine Hypothesis of Schizophrenia: A Reappraisal
(M. Sandlzn.) 1842
Catecholamines and Metabolites in the Brains of Psychotics and
Normals: Post-Mortem studies [Joel E. Klzinman, Pztzn. Bnidgz, FaAouk
KaAoum, Sam Spzcialz, Rickand Staub, Stzvzn lalcman, J. CkniAtian
Gillin and Richand Jzd Wyatt). . 1845
Skeletal Muscle Monoamine Oxidase Activity in Psychiatric Pa¬
tients and Normal Controls [Ramzih C. AAOAa and HeAbzAt Y. Mzltzzh.) ,1848
FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM Xlx
Propranolol Treatment of Chronic Schizophrenia: Clinical
Response, Catecholamine Metabolism and Lymphocyte g-Receptors
[Llzwellyn B. Bigzlow, Stzvzn lalcman, Joel E. Klzinman, Vanizl
WzinbzAgzA, Vanizl Luckini, John Tollman, FaAouk KaAoum and
Richand Jzd Wyatt) 1851
Phenylethylamine, A Putative Dopaminergic Agonist: Its;
Possible Role in the Pathogenesis of Schizophrenia [G.P. Rzynoldi,C.R.J. Ruthvzn, B.L. Goodwin and M. Sandlzh) 1854
Genetics and Biochemistry of Schizophrenia in a Defined
Population [Lznnant WztX.zh.bzAg, Jan A. Book, Ylva Flodzhui and
Svantz B. Ron) 1857
Biochemical Discrimination of Subtypes of Depressive Dis¬
orders (Joseph J. Schild.kna.ut, Paul J. OhAulak, Alan F. Schatzbzng,Jon E. Gudzman, Jonathan 0. Colz, RichaAd A. LaBniz and William
Rohdz) 1860
Norepinephrine Metabolite Studies in Affective Illness
[FAzdznick K. Goodwin and William 1. Pottzn.) 1863
Studies of Norepinephrine Metabolism in Manic and Depressive
States [Anqzloi E. HalohiA and Edutand M. VeUet) 1866
Platelet MAO and Urinary MHPG in Affective Disorders [Vavid
J. Edwandi, Vuanz G. SpikeA, Vavid J. Kupizn. and John F. Neil). . . 1869
Trace Amines in Depression: Tyramine and Octopamine Deficit
(M. Sandlzh., C.R.J. Ruthvzn, B.L. Goodwin, G.P. Rzynoldi, A. Coppzn) 1872
Metabolism and Turnover of MHPG in the Monkey (P. Blombzhy,I.J. Kopin, E.K.Gohdon and M.H. Ebznt) 1875
Neurotransmitter Metabolite Production by Human Brain [Jamei ill.
Maai, Nicholai M. GKzznz, Suian E. Hattox and V. Hanold Landii) . .1878
Research Strategies in Depression: A Clinical Pharmaco-
therapeutic Approach (Baton Shopiin) 1881
Dopamine Metabolites in Brain Regions of Schizophrenics
[Nicholai G. Bacopouloi, Edwahd V. Bind and Robznt H. Roth) .... 1884
Plasma and CSF Dopamine Metabolites in Psychiatric Patients:
Effects of Probenecid and Haloperidol (G. HzningeA, N. Bacopouloi,
R. Roth, M. Bowzaa, Ja. and V. Swzznzy) 1887
Heterogeneity of Prolactin Response to Haloperidol (RobeAt T.
Rubin and Sally E. Hayi) 1890
Cerebrospinal -?luid (CSF) Homovanillic Acid (HVA), CyclicAdenosine Mono-Phosphate (cAMP), Prolactin and Serum Prolactin in
Acute Psychotic Patients at Two Points During Early Chlorpromazine
(cpz) Treatment (M.S. BoweA6, Jn., G.R. HzningeA and H.Y. Mzltzzn.) 1893
Heterogeneity in Response to Amphetamine in Schizophrenia:Effects of Placebo, Chronic Pimozide and Pimozide Withdrawal [Vanizl
P. van Kammzn and William E. Bunnzy, Jn..) 1896
Dopaminergic Agents in Affective Illness: Studies with
Piribedil, Amphetamine and Pimozide [RobzAt M. Poit, Vavid C. Jimzuon,
ilicton. 1. Rzua, FfLzdzhick K. Goodwin, Edwand Sitbzhman and W.E.
Bunnzy, Ja. ). .
1899
Methylphenidate Induced Changes in Behavior, Growth Hormone
and Prolactin [V.S. JawWiky, L.L. Judd, L. Huzy, V. Pahkzh. and
P. Lzicknzn.) 1902
FOURTH INTERNATIONAL CATECHOLAMINE SYMPOSIUM
Dopamine and Schizophrenia: Relationships to Blinking and
REM (J.R. Stzvzni, A. Livzhmofiz, Ja.,
K. Wztzel and S. Roiznblum). . 1905
Catecholamine Metabolizing Enzymes and Primary Affective
Disorders [Vavid L. VunneA and Ronald R. Fizvz) . 1908
The Effect of Lithium Pretreatment on Cardiovascular and Be¬
havioral Responses to Amphetamine (B. AnghiAt and 5. GzAihon) .... 1911
Urinary Amine Metabolites as Predictors of Response to
Antidepressant Medication (A. Paulinz RidgeA) , 1914
Urinary 3-Methoxy-4-Hydroxyphenethylene Glycol and State
Variables in Affective Disorder [Vonald R. Swzznzy, Jamzi W. Maai
and Vavid Pickax) 1917
EEG Sleep and Affective Disorders: What Can it Predict?
[Vavid J. Kuplex, Vuanz G. Spikzn, Patxicia Coblz, John F. Neil,linazl Hanin, Vavid J. Edwoxdi, Richaxd J. McPantland, Vavid H.
Shaw, Bahxy Holzzn. and Tkomai Ghau) .1920
Clinical Studies With Drugs Affecting Biogenic Amine Mechanisms
[Louii LembzAgzA, H. Rowz, R. Caxmichael and R. Chjabtxtt) 1923
Brain and Platelet Monoamine Oxidase (MAO) Activities in
Relation to Ethanol Abuse (L. QKzland, C.-G. Gott{hizi, A. WibeXg and
B. Winblad) 1925
Platelet Monoamine Oxidase and Cortical Evoked Potentials as
Predictors of Psychiatric Vulnerability [RichaAd J. HaieX, Montz S.
Buchibaum and Vznnii L. Muxphy) 1928
Noradrenaline and Fear [Stzphzn T. Maion and Hani C. Fibigzh.) . 1931
Reduced Erythrocyte COMT and Plasma DBH Activities Not Associated
With Affective Disorders in Patients and Relatives [Elliot S. GZAihon,C. Raymond Lakz and Jamzi F. Lzckman) 1934
Catecholamine Response to Short-Time Stress in Schizophrenicand Depressive Patients (M. Ackznhzil, M. AlbuA, F. M'ullZA, Th.
M'ultex, V. Wzltex, K. landzn. and R. Engel) 1937
Serum Dopamine-B-Hydroxylase in Schizophrenic Patients
[K. Fujita, T. Ito, K. Mahuta, R. Texadaixa, H. Bzppu, V. Nakagami,V. Koto, T. Nagatiu and T. Koto) 1940