Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.
-
Upload
kallie-langmaid -
Category
Documents
-
view
214 -
download
1
Transcript of Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.
![Page 1: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/1.jpg)
Institute of Food Research
IFR FORWARDOPEN DAY 2006
7 September 2006
![Page 2: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/2.jpg)
2
GutBiology
Nutrition,Diet & Health
MolecularMicrobiology
FoodBiophysics
IFR Science Skills Base
![Page 3: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/3.jpg)
3
GutBiology
Understanding gut health and function
Good Guys
11
Eat for Life
5
![Page 4: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/4.jpg)
4
GutBiology
Nutrition,Diet & Health
A volunteer’s life
How our diet influences our long-term health
Human Nutrition Unit
11
![Page 5: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/5.jpg)
Obesity Trends* Among U.S. AdultsBRFSS, 1985
No Data <10% 10%–14%
Source: Behavioral Risk Factor Surveillance System, CDC
![Page 6: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/6.jpg)
No Data <10% 10%–14%
Obesity Trends* Among U.S. AdultsBRFSS, 1986
Source: Behavioral Risk Factor Surveillance System, CDC
![Page 7: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/7.jpg)
No Data <10% 10%–14%
Obesity Trends* Among U.S. AdultsBRFSS, 1987
Source: Behavioral Risk Factor Surveillance System, CDC
![Page 8: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/8.jpg)
No Data <10% 10%–14%
Obesity Trends* Among U.S. AdultsBRFSS, 1988
Source: Behavioral Risk Factor Surveillance System, CDC
![Page 9: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/9.jpg)
No Data <10% 10%–14%
Obesity Trends* Among U.S. AdultsBRFSS, 1989
Source: Behavioral Risk Factor Surveillance System, CDC
![Page 10: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/10.jpg)
No Data <10% 10%–14%
Obesity Trends* Among U.S. AdultsBRFSS, 1990
Source: Behavioral Risk Factor Surveillance System, CDC
![Page 11: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/11.jpg)
No Data <10% 10%–14% 15%–19%
Obesity Trends* Among U.S. AdultsBRFSS, 1991
Source: Behavioral Risk Factor Surveillance System, CDC
![Page 12: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/12.jpg)
No Data <10% 10%–14% 15%–19%
Obesity Trends* Among U.S. AdultsBRFSS, 1992
Source: Behavioral Risk Factor Surveillance System, CDC
![Page 13: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/13.jpg)
No Data <10% 10%–14% 15%–19%
Obesity Trends* Among U.S. AdultsBRFSS, 1993
Source: Behavioral Risk Factor Surveillance System, CDC
![Page 14: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/14.jpg)
No Data <10% 10%–14% 15%–19%
Obesity Trends* Among U.S. AdultsBRFSS, 1994
Source: Behavioral Risk Factor Surveillance System, CDC
![Page 15: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/15.jpg)
No Data <10% 10%–14% 15%–19%
Obesity Trends* Among U.S. AdultsBRFSS, 1995
Source: Behavioral Risk Factor Surveillance System, CDC
![Page 16: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/16.jpg)
No Data <10% 10%–14% 15%–19%
Obesity Trends* Among U.S. AdultsBRFSS, 1996
Source: Behavioral Risk Factor Surveillance System, CDC
![Page 17: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/17.jpg)
No Data <10% 10%–14% 15%–19% ≥20
Obesity Trends* Among U.S. AdultsBRFSS, 1997
Source: Behavioral Risk Factor Surveillance System, CDC
![Page 18: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/18.jpg)
No Data <10% 10%–14% 15%–19% ≥20
Obesity Trends* Among U.S. AdultsBRFSS, 1998
Source: Behavioral Risk Factor Surveillance System, CDC
![Page 19: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/19.jpg)
No Data <10% 10%–14% 15%–19% ≥20
Obesity Trends* Among U.S. AdultsBRFSS, 1999
Source: Behavioral Risk Factor Surveillance System, CDC
![Page 20: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/20.jpg)
No Data <10% 10%–14% 15%–19% ≥20
Obesity Trends* Among U.S. AdultsBRFSS, 2000
Source: Behavioral Risk Factor Surveillance System, CDC
![Page 21: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/21.jpg)
No Data <10% 10%–14% 15%–19% 20%–24% ≥25%
Obesity Trends* Among U.S. AdultsBRFSS, 2001
Source: Behavioral Risk Factor Surveillance System, CDC
![Page 22: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/22.jpg)
No Data <10% 10%–14% 15%–19% 20%–24% ≥25%
Obesity Trends* Among U.S. AdultsBRFSS, 2002
Source: Behavioral Risk Factor Surveillance System, CDC
![Page 23: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/23.jpg)
23
GutBiology
Nutrition,Diet & Health
MolecularMicrobiology
Understanding and controlling bacterial foodborne pathogens
Good Guys
11
Bad guys
10,15
![Page 24: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/24.jpg)
24
GutBiology
Nutrition,Diet & Health
MolecularMicrobiology
FoodBiophysics
Maintaining food quality with a healthy diet
Feelgood foods
oil7
![Page 25: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/25.jpg)
25
GutBiology
Nutrition,Diet & Health
MolecularMicrobiology
FoodBiophysics
Gut
IFR Science Skills Base
![Page 26: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/26.jpg)
26
New Research Leaders
●Systems Biology
●Gut Biology
●Molecular Immunology
●Molecular nutrition
![Page 27: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/27.jpg)
27
● ‘omics Transcriptomics –
microarrays Proteomics Metabolomics
● Imaging TEM, SEM, Light
Microscopy Nmr Atomic Force
Microscopy
IFR Technology Skills Base
15
11
Oh Me, Oh my – omics and Where’s Wally3
2
![Page 28: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/28.jpg)
28
Exploitation Platforms
●Sustainability of food chain Keith Waldron
●Magnetic Resonance Imaging Brian Hills
●Model Gut Martin Wickham
●National Collection of Yeast Cultures Ian Roberts
●Food Databanks Paul Finglas
●Microbial Ecology Tim Brocklehurst
![Page 29: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/29.jpg)
29
●Facilitates a knowledge-based industry
●Helps develops relationships between IFR and its industry stakeholders that bring mutual benefits
●Cost-effective knowledge-sharing
www.foodandhealthnetwork.com - promoting an environment where food Industry professionals can network with research scientists
![Page 30: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/30.jpg)
30
Activities
Regular Cluster meetings on relevant topics
Cross-cluster meetings on areas of more general interest at locations convenient to industry (North and South). Proposed topics now available on FHN stand
FHN Direct: 1:1 consultations on confidential basis at IFR or on-site
![Page 31: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/31.jpg)
31
●The Clusters & their Leaders
Allergy – Clare Mills
Co-product exploitation – Keith Waldron
Food Structure & Nutrition – Pete Wilde
Pathways to personalised nutrition – Siân Astley
Predictive Microbiology & Risk Analysis – Jòzsef Baranyi
Quality throughout Shelf-Life – Reg Wilson
![Page 32: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/32.jpg)
32
Food & Health Network “Direct”
●One-to-one collaboration with the food industry
●Your issues – our complementary skills
![Page 33: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/33.jpg)
33
Norwich Research Park
IFR
UEA Triangle
JIC
HospitalNNUH
UEA Main Campus
PBL
UEA● Institute of Health
Medical School● Computer Science● Chemistry & Pharmacy● Biology
PBL• Licensing• Patent Protection• Market Research
NNUH● Clinicians within IFR● Histo-pathology● Tissue Bank● Numerous depts
Youare
here
John Innes Centre• Plant/microbe genetics• Crop development
![Page 34: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/34.jpg)
34
European Agenda
●Member of Initiative Group (with Wageningen and Unilever) for development of a vision document for a
European Technology Platform: Food for Life
Food and Health Food Quality and
ManufacturingConsumer and the
integrated food chain
![Page 35: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/35.jpg)
35
![Page 36: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/36.jpg)
36
● ‘omics Transcriptomics –
microarrays Proteomics Metabolomics
● Imaging TEM, SEM, Light
Microscopy Nmr Atomic Force
Microscopy
●Bioinformatics Statistics Modelling High-throughput
analysis
●Human Nutrition Unit
●National Collection of Yeast Cultures
IFR Technology Skills Base
8
12
![Page 37: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/37.jpg)
37
Strategic Plan: Vision and Mission
Mission
●Undertake international quality scientific research relevant to food and human health
●Work in partnership with others to provide underpinning science for consumers, policy makers, the food industry and academia
Vision
●to be a world-leading contributor to harnessing food for health and controlling food-related disease
![Page 38: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/38.jpg)
38
IFR
● The Institute of Food Research (IFR) is a not-for-profit company with charitable status
● Sponsored by the Biotechnology & Biological Sciences Research Council
IFR and IFR Enterprises Ltd are registered to the quality standard ISO 9001
![Page 39: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/39.jpg)
39
Strategic Plan: “Objectives”
●Gastrointestinal Tract Biology: Understanding gut health and function
●Nutrition, Diet and Health: Understanding how our diet influences our long-term health
●Food Innovation: Maintaining food quality with a healthy diet
●Food Safety: Understanding and controlling bacterial foodborne pathogens
![Page 40: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/40.jpg)
40
IFR
Turnover ~ £15m pa
● 190 scientific staff, 18 PhD students
● Admin Support joint with JIC
9.1
![Page 41: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/41.jpg)
41
Outputs
●High-quality science base Research papers
●Underpinning evidence for policy – especially for Government (FSA, Defra, DH) Influence on policy
●Knowledge Transfer – especially for industry Collaboration Licensing, spin-outs etc
![Page 42: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/42.jpg)
42
GI TractBiology
NutritionDiet & Health
FoodInnovation
FoodSafety
Mass Spectrom
etry
Met
abol
omic
s
Functional Genomics
Human Nutrition Unit
Ato
mic F
orce
Micro
scop
yC
on
foca
lS
EM
, T
EM
FTIR
Animal Facilities
BasicScience
Micro-biologists
Bio-chem
ists
An
alyt
ical
C
hem
ists
Ph
ysicists
Physiol-
ogists
Physical
Chemists
Pla
nt
Sci
enti
sts
Nutritionists
Social
Scientists
Mat
hemat
-
icia
ns
![Page 43: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/43.jpg)
43
GI TractBiology
NutritionDiet & Health
FoodInnovation
FoodSafety
Mass Spectrom
etry
Met
abol
omic
s
Functional Genomics
Human Nutrition Unit
Ato
mic F
orce
Micro
scop
yC
on
foca
lS
EM
, T
EM
FTIR
Animal Facilities
Micro-biologists
Bio-chem
ists
An
alyt
ical
C
hem
ists
Ph
ysicists
Physiol-
ogists
Physical
Chemists
Pla
nt
Sci
enti
sts
Nutritionists
Social
Scientists
Mat
hemat
-
icia
ns
Allergy
Obesity
Emerging Pathogens
Microbiol safety of the food chain
Waste / Sustainability
Bioterrorism
Ageing Population
Quality in the food chain
Diet and Disease
Strategic Relevance
![Page 44: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/44.jpg)
44
GI TractBiology
NutritionDiet & Health
FoodInnovation
FoodSafety
Mass Spectrom
etry
Met
abol
omic
s
Functional Genomics
Human Nutrition Unit
Ato
mic F
orce
Micro
scop
yC
on
foca
lS
EM
, T
EM
FTIR
Animal Facilities
Micro-biologists
Bio-chem
ists
An
alyt
ical
C
hem
ists
Ph
ysicists
Physiol-
ogists
Physical
Chemists
Pla
nt
Sci
enti
sts
Nutritionists
Social
Scientists
Mat
hemat
-
icia
ns
ClostridiaGM identity
Authenticity
Micronutrientdeficiency
Pathogen Elimination
GM andNovel Foods
Colon Health
FSA
![Page 45: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/45.jpg)
45
Influence on policy
The institute has made important contributions to the development of UK policy on e.g.:
●Dietary fibre (throughout the 1990s)
●Fruits and vegetables (development of 5-a-day advice - 1998)
●n-3 fatty acid consumption (from fish - 1999)
●Mineral nutrition (1990s and 2000s)
●Colonic health (late 1990s)
●Shelf-life of chilled foods (2000s)
![Page 46: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/46.jpg)
46
Delivery
●Programmes
●Partnerships
●Exploitation Platforms
![Page 47: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/47.jpg)
47
Programmes
Shortform title Prog Leader
●GI tract biology and health Ian Johnson
●Commensals & microflora Mike Gasson
●Phytochemicals & Health Richard Mithen
●Micronutrients Sue F-Tait
●Personalised (mol) Nutrition to be appointed
●Structuring foods for health Clare Mills
●Pathogens: mol microbiol Jay Hinton
●Pathogens: Phys & Pred Ecol Mike Peck
![Page 48: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/48.jpg)
48
Internal Partnerships
●Bioinformatics and statistics Kate Kemsley
●Technologies for Systems Biology Transcriptomics
Tony Michael Proteomics Metabolomics
●Risk & Consumer Science Nigel Lambert
● Imaging Vic Morris
● [Support Units] [HNU, North SiteUEA]
![Page 49: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/49.jpg)
49
Research Collaborations
●Our scientific research collaboration stretches across the world through informal and formal partnerships. Examples:
![Page 50: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/50.jpg)
50
![Page 51: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/51.jpg)
51
Molecular Microbiology
![Page 52: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/52.jpg)
52
Nutrition, Diet and Health
![Page 53: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/53.jpg)
Obesity
Body Mass Index (BMI): a measure of an adult’s weight in relation to height, specifically the adult’s weight in kilograms divided by the square of his or her height in meters.
Obesity: having a very high amount of body fat in relation to lean body mass, or Body Mass Index (BMI) of 30 or higher.
Overweight: a BMI between 25 and 30.
![Page 54: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/54.jpg)
Case 2: Obesity
![Page 55: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/55.jpg)
55
Gut Biology
![Page 56: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/56.jpg)
56
Norwich Research Park
IFR
UEA Triangle
JIC
HospitalNNUH
UEA Main Campus
PBL
UEA● Institute of Health
Medical School● Computer Science● Chemistry & Pharmacy● Biology
PBL• Licensing• Patent Protection• Market Research
NNUH● Clinicians within IFR● Histo-pathology● Tissue Bank● Numerous depts
Sainsbury Laboratory
Youare
here
![Page 57: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/57.jpg)
57
GutBiology
Nutrition,Diet & Health
MolecularMicrobiology
FoodBiophysics
IFR Skills Base
![Page 58: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/58.jpg)
58
Functional Genomics / Systems Biology
Genome SequencesPathogensSalmonella entericaCampylobacter jejuniClostridium botulinum
CommensalsLactococcus lactisLactobacillus johnsoniiBifidobacterium breve
L. LactisMG1363
![Page 59: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/59.jpg)
59
Bacterial Microarrays @ IFR 2006• “SALSA” 4 Salmonella serovars 5600 genes
• “ShE. Coli” 6500 genesE. coli O157 & Shigella flexneri
+ 150 EPEC/ ETEC virulence genes
• Campylobacter jejuni 1800 genes, plus plasmids
• Clostridium botulinum 3456 genes
• Lactococcus lactis 2587 genes
• Coming soon: Bifidobacterium breveLactobacillus johnsonii
![Page 60: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/60.jpg)
6012 Macrophage J774-A.1 SL134404 Macrophage J774-A.1 SL1344
0.01
0.1
1
10
100 Normalized Intensity(log scale)
Normalised Macrophage infection 100
10
1
0.1
0.01
Salmonella Compendium Database 1.0
Macs 4,8,12hHeLa 2,4,6h
hns
pH3.0hilACD
MM-low glucose ATR pH5.5
phoP
![Page 61: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/61.jpg)
SPI1 caught napping?
• Hierarchical clustering of EnviCom
• SPI1 genes cluster with 5 nap genes
• A co-regulatory mechanism?
• Do the nap genes play a role in invasion?
napFDHBC
SPI1
SPI1
![Page 62: Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.](https://reader030.fdocuments.net/reader030/viewer/2022032516/56649c425503460f948effd9/html5/thumbnails/62.jpg)
GutBiology
Nutrition,Diet & Health
MolecularMicrobiology
FoodBiophysics
IFR Skills Base