IDA Ireland positions Dundalk for major BioPharma investment July 2008

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IDA Ireland positions Dundalk for major BioPharma investment

IDA Ireland is to seek advance planning permission from Louth County Council to facilitate the potential establishment of two major BioPharma facilities and related high quality office developments at the IDA Dundalk Science & Technology Park at Mullagharlin, Dundalk, Co. Louth.

Seeking advance planning permission is part of an IDA Ireland strategy to enable Ireland to enhance its competitiveness globally for inward investment. The strategy has been developed in recent years, in the face of growing international competition, to strategically position Ireland for high value inward investment projects.

Ireland’s key strengths in attracting inward investment have been our highly educated and flexible workforce, our enterprise friendly taxation and regulatory environment and the package of State assistance on offer. However, despite these incentives, there is intense international competition for mobile investment and many of the incentives that Ireland offers are now matched by competitor countries around the globe.

The 44 hectare IDA owned land bank at Mullagharlin, south of Dundalk, has been selected as an ideal location for the establishment of a world-class Science and Technology Park. This is due to its strategic location just off the M1, its position at the centre of the north-south economic corridor, its proximity to Dublin airport and major ports and its access to Dundalk Institute of Technology (DkIT) and a pool of over 80,000 students in the Universities and Institutes of Dublin and Belfast.

The BioPharma sector has provided thousands of high quality jobs, particularly for graduates contributing to the establishment of Ireland as a knowledge-led economy. In addition, the planning application for the Park at Mullagharlin will include proposals to develop office and support facilities suitable for science and technology businesses that will offer a range of employment opportunities and also contribute significantly to the local economy.

Over the following pages you will find further details on the proposal and information on the Science & Technology Park, as well as answers to some anticipated questions.

We hope that this is the beginning of a process that will in the future see the establishment of a major, high value, knowledge intensive investment locating in Dundalk.

IDA Ireland is seeking the support of the local community for this prestigious project, which will positively position Dundalk for major high value, technology investments in the future which can deliver high calibre employment opportunities and associated benefits to the entire northeast region.

Barry O’Leary Chief Executive, IDA Ireland

Barry O’Leary Chief Executive IDA Ireland

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The Park is being developed by IDA Ireland as one of Ireland’s strategic national business

site offerings. Substantial and major investment has been undertaken to provide world-

class infrastructure at the Park including installing the latest technologies in utilities

and services, an internal road network which is all set in a low impact parkland setting.

The Park is being developed to match and surpass the highest international design

standards in order to provide the northeast region with a world-class location for

attracting inward investment opportunities.

Scale: NTS

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1. This drawing is the property of RPS Group Ltd.. It is a confidential document and must not be copied, used, or its contents divulged without prior written consent.2. All levels are referred to Ordnance Datum, Malin Head.3. Ordnance Survey Ireland Licence No. EN 0005008 Copyright Government of Ireland.

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Site Location

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SITE LOCATION

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SiteLocation

Ireland, a home for BioPharma excellence

BioPharma manufacturing is still in its relative infancy in comparison to more traditional

pharmaceutical process techniques and it has only really come to the fore during the past 15 years.

A huge proportion of new drug therapies in development and production across the globe are now

being manufactured using next generation BioPharma processes.

What is BioPharma?Biopharmaceuticals are a key product sector within the

Pharmaceutical industry. They allow the production of

complex biologically active molecules to treat a wide

variety of conditions. In 2007, there were over 400

BioPharmaceutical products on the market in the USA

with a further 8,600 in clinical trials around the world.

The existing products currently treat over 200 diseases

and millions of patients worldwide.

Pharmaceutical companies have made significant

investments in BioPharmaceutical facilities within Ireland in

the last decade and IDA Ireland is committed to continuing

to facilitate the inward investment in this expanding sector

of the Pharmaceutical industry.

The production of BioPharmaceuticals is a lengthy process

and it can take several months to produce the final finished

and packaged product. The processes are carefully

controlled and operate in sealed systems located within

controlled environments in order to protect the purity of

the products, which are often injected directly into patients

bypassing all immunity systems. This contained production

ensures the absolute safety of the manufacturing processes.

Ireland’s Biotechnology industry is well

set for strong growth. Through IDA

Ireland, we continue to attract major

projects from leading BioPharma and

Biotechnology companies to Ireland.

Thirteen of the world’s top 15 Pharma

companies have established operations

in Ireland and the sector currently

employs over 4,000 people.

Ireland already has a strong BioPharma

manufacturing sector typified by

companies like Allergan, Centocor,

Bristol-Myers Squibb, Genzyme, Lilly,

Merck Sharp & Dohme, Pfizer,

Schering-Plough and Wyeth.

IDA Ireland believes that Ireland has

continuing and growing potential to

attract further investment from the

Biotechnology and BioPharma sectors.

Having in place a strategic planning

approval such as the one proposed for

Dundalk extends IDA Ireland’s ability

to market the region as a suitable

and welcoming location for potential

knowledge-led investment.

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The Advance Planning Permission Strategy

The application for the IDA Dundalk Science &

Technology Park represents a continuation of a

defined strategy developed by IDA Ireland whereby

an advance planning application which anticipates

future client requirements is submitted to the local

planning authority.

The planned design of the Mullagharlin site is

based on the IDA’s extensive experience of the

establishment of similar facilities elsewhere in

Ireland and abroad. Accordingly the planning

application seeks a ten-year permission to develop

BioPharma manufacturing facilities designed to

facilitate the likely range of requirements of future

IDA clients.

While the advance planning permissions will allow

an investor to commence construction almost

immediately they will still require to apply and

obtain an Integrated Pollution Prevention Control

Licence (IPPCL) and Fire Safety Certificates before

any manufacturing can commence.

Ireland’s planning process is one of the most

stringent and transparent in the world. Our

planning process protects our environment and

ensures that only appropriate development is

permitted.

The purpose of the planning application is to prepare the site for future BioPharma, science

and technology based activity. Having planning permission in place will enhance a competitive

advantage to attract inward investment from the BioPharma manufacturing sector.

Modern technologically advanced industries

such as BioPharma manufacturing are

characterised by ever shortening product

lifecycles and rapid time to market is a key

component of competitive advantage. When

companies in this sector decide to add

capacity, a key-determining factor on the

location of the new investment is the speed

at which a facility can be established and

production brought on-stream.

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The Dundalk Proposal

IDA Ireland has recently

completed substantial

infrastructural works to

provide the necessary

services to the Dundalk

Science & Technology Park,

which will enhance the Park

as a location for investment.

IDA Ireland has engaged the services of leading

international industrial facility engineers

Jacobs Engineering and an experienced consultancy

team to undertake the design of the proposed facilities

in the Science & Technology Park.

The design conforms to the best practice standards

being applied by leading edge BioPharma facilities

in the world today and could lead to the development

in Dundalk of a world-class centre of excellence in

BioPharma manufacturing.

The proposal seeks the creation of a world-class

Science & Technology Park at Mullagharlin. The Park

will be capable of accommodating both mid to large

size and mid to small size Biotechnology facilities;

depending on the needs of an investor, together with

ancillary office accommodation, all to be located in a

highly attractive and well landscaped campus and

parkland setting.

Artist’s impression of proposed facilties

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M1N52

44 Ha

CrownePlazaHotel Xerox

DundalkInstitute ofTechnology

IDA Ireland will submit a planning

application for approval by the

local authority, Louth County

Council, for the construction of two

BioPharma facilities and six office

buildings on the campus. Each

of the Bio facilities will include

laboratories, manufacturing

areas, office accommodation and

supporting infrastructure.

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The IDA Dundalk Science & Technology Park will consist of the following:

A small to mid-sized BioPharma facility:

A four storey Bulk Fermentation

Building of approximately 13,000

square metres in size with a 20,000 to

40,000 litre fermentation capacity;

A three storey Fill Finish Building of

approximately 4,800 square metres

housing a syringe and vial filling lines;

A Warehouse of approximately 3,300

square metres including dispensary

and cold rooms;

A Utilities Building of approximately

1,500 square metres in size;

A Bord Gáis Éireann natural gas

pipeline connection;

A tank farm and ancillary services

facility;

Associated office support buildings;

Parking for 200 cars to accommodate

total staff numbers of between 200 and

300.

A mid to large-sized BioPharma facility:

A four storey Bulk Fermentation

Building of approximately 30,000

square metres with a 40,000 to 70,000

litre fermentation capacity;

A three storey Fill Finish Building of

approximately 5,000 square metres

housing a syringe and vial filling lines;

A Warehouse of approximately 4,400

square metres including a dispensary

and cold rooms;

A Laboratory and Administration

Building of approximately 15,000

square metres in size;

A Combined Utilities Building of

approximately 3,000 square metres;

A Bord Gáis Éireann natural gas

pipeline connection;

A tank farm and ancillary services

facility;

Associated office support buildings;

Parking for 500 cars to accommodate

total staff numbers of between 550 and

650.

Science & Technology Office Accommodation

Four storey large office buildings of

approximately 3,500 square metres

each;

Two small office buildings of

approximately 2,200 square metres

each;

A Bord Gáis Éireann natural gas

pipeline connection;

Parking for 400 cars to accommodate

total staff numbers of between 700 to

800.

Site Masterplan

LEGEND

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Why Dundalk?Dundalk is ideally located for the

development of ‘knowledge-led’

investment for several reasons.

These include Government and

regional spatial economic policy

which has designated it a Gateway

town, the town’s long established

reputation for excellence in process

manufacturing, its central strategic

position on the north-south ‘economic

corridor’ and because of the well-

educated labour pool in the region.

The completion of the M1 and other road links from

Dublin to Belfast sees the town located adjacent to

a highly significant strategic transport corridor. The

upgraded Dublin to Belfast rail line has also further

enhanced the town’s position in this respect.

All of these developments significantly expand the

town’s natural catchment and increase speed of access

to airports and major sea transport links.

More importantly, however, the area is located within a

commuter region, which is home to many of the world’s

leading Biotechnology and BioPharma companies. This

means that there is also access to a pool of skilled and

experienced staff and a good supply of well-educated

graduates who will be required by knowledge intensive

investments of the nature proposed.

Dundalk Institute of Technology

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Dundalk 2020Coordinated by Sustainable Energy Ireland (SEI), the Dundalk 2020 project initially

focuses on developing a four square kilometre sustainable energy zone in the town.

The project goal, fully supported by IDA Ireland, is to demonstrate how all sectors

can collectively work to significantly reduce their impact on the environment through

a series of initiatives to improve sustainable energy practices across the country.

This aspiration is backed up by specific targets agreed for the sustainable energy

zone to be achieved by 2010, with the commitment to supply 20 per cent of heat and

electricity from renewable sources and improving energy efficiency in designated

buildings by 40 per cent.

IDA Ireland is fully committed to supporting the initiative and plans to include measures

to support energy efficiencies and sustainability at the IDA Dundalk Science &

Technology Park.

Dundalk Institute of Technology

Artist’s impression of proposed facilties at night

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The EnvironmentWhen completed the Park will provide Dundalk with a centre of excellence showcased in-high quality

landscaped surrounds. The landscaping will result in an attractive low-impact parkland environment

with berms and water features including ponds attracting a varied range of wildlife. The perimeter of the

site will be planted heavily with mature native tress, plants and shrubs to result in an attractive visual

landscape for neighbours.

The Environmental Impact Statement

An Environmental Impact Statement (EIS) will

be prepared as part of the planning application

and will contain an analysis of the likely effects

of the development on the local environment

and mitigation measures to be in put in place to

minimise any potential impacts.

The EIS will also include a summary of the

project proposal in non-technical language.

Some of the proposed measures to protect the

environment include:

Archaeological A detailed archaeological survey has been

undertaken. A souterrain of importance has

been identified and it will be the subject of a

protection order, which means that it will be

preserved.

Flora & Fauna The site has been farmed in recent years

resulting in no significant impact on flora

and fauna in the area.

Landscape & Visual Impact A detailed landscape plan will be implemented

taking account of views around the site and

encouraging biodiversity through planting of native

shrubs and trees.

WildlifeWater features such as ponds will be set into the

site, which we hope will encourage a greater mix of

wildlife than presently exists.

TrafficThe site is serviced by its own direct access road

from the southern link road (N52) near the Xerox

facility. By having direct access to the site, traffic

impacts on local residents will be minimised.

NoiseMeasures mitigating against noise will be put in

place prior to any construction work commencing

to reduce impacts on neighbours. These measures

will include heavy tree planting and the setting of

berms to reduce noise emissions.

There will be no traffic impacts to local residents surrounding the Park from service or other vehicles, as

direct access is provided to the site. Access to the Science & Technology Park is via the new access road

which links directly to the N52 Southern Link Road at the roundabout to the west of Xerox Business Park.

Electricity

The planning application includes a proposal for the construction

of a new 110Kv sub-station to facilitate the future power needs of

the Park. Underground ducting exists in the recently completed

road infrastructure to allow for power to be distributed to the

Park.

Telecoms and IT

The IDA Dundalk Science & Technology Park is being developed

to take account of all IT and Telecom requirements. Provision

has been made within the new road infrastructure to facilitate a

number of different telecoms providers and to link the Park to the

Metropolitan Area Network (MAN).

Water Supply & Drainage

The Park is served by a recently installed twin 350mm diameter

trunk water mains. All developments within the Park will

provide for on-site attenuation in the form of attenuation ponds

/ lakes thus minimising the peak surface water run-off from the

Park.

Sewerage

A pumping station will be constructed on-site to enable the

Park to be served by the Dundalk Town Council Inner Relief

Road trunk sewer, which conveys sewage to the Coes Road

pumping station and on to the main municipal treatment works

at Soldiers Point.

As part of the continuing development of the

Park, essential business services are being made

available including infrastructure, electricity, gas,

water, drainage and fibre optic cabling for high

speed broadband access.

Utilities and Services

The design development of the Science &

Technology Park takes account of providing

services and related infrastructure such as water

supply, effluent treatment, surface water disposal,

electrical power, gas and communications required

for such landmark developments. The existence

of these services nearby allows these utilities to

readily facilitate this proposed development and will

minimise disruption in the vicinity of the Park.

Gas

Negotiations have taken place with Bord Gáis

to access the North-South Interconnector for

the provision of gas supply. An Above Ground

Installation (AGI) to be located within the Park

will reduce supply pressure from the trunk main

and this will provide sufficient gas supply to

service operations in the Park. The AGI will be

subject to a seperate planning application to

Louth County Council.

Existing and Planned Services & Utilities

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Planning ApplicationThe planning application will be accompanied by an Environmental Impact Statement

and will be subject to the statutory procedures and public notice requirements.

When lodged in mid-July, the planning application can be inspected or a copy purchased

for a fee at the offices of Louth County Council, County Hall, Millennium Centre, Dundalk,

Co. Louth, Monday to Friday from 9.00am to 4.00pm.

InformationThe IDA Dundalk Science & Technology

Park planning application is an

exciting strategic initiative designed

to attract high-value BioPharma

investment to Dundalk over the next

few years.

The planning application will be

lodged with the local authority,

Louth County Council in mid-July 2008.

IDA Ireland through its Dundalk office

will be happy to assist with any enquiry

on the proposed development, which

might arise. Please direct any enquiry

by telephone to IDA’s Dundalk office at

042 935 4410.

In addition, IDA Ireland will host an Information

Drop-In Centre over a five-week period at

IDA Ireland’s Dundalk office at Finnabair Business

Park following the submission of the planning

application.

Following the submission of the advance planning

application, the Information Centre will be open

to enquiry / visit on each Thursday evening from

7.00pm to 9.00pm and on each Saturday morning

from 10.00am to 12 noon up to Saturday, 23rd

August 2008.

Feel most welcome to call or visit as IDA Ireland

will be delighted to showcase and discuss its

proposal, confident of the great benefit that a

planning approval for the proposed development

can bring to Dundalk and to the region.

NOTE: This brief

has been produced

for information

purposes only and all

images used are for

illustration only.

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Questions Answered:Does IDA Ireland have a specific company in mind for Dundalk?

No. IDA Ireland is in constant contact with the world’s leading Pharmaceutical companies.

It is hoped that with an advance planning permission in place that one of these can be

enticed to commit to a significant investment in Dundalk.

Who are these companies?

There are a number of world leaders in the BioPharma field. It would be inappropriate

for IDA Ireland to mention any of them at this point lest this gives rise to any unwarranted

speculation as to the possible likely identity of any future occupant of the IDA Dundalk

Science & Technology Park.

Why is BioPharma manufacturing seen as being of such key importance?

BioPharma manufacturing is at the very forefront and leading edge activity of the global

Pharmaceutical industry. Locations, which boast major BioPharma campuses, tend to

be those which also play host to major clusters of other Biotechnology and Healthcare

companies. Furthermore, the BioPharma sector is highly knowledge intensive and this fits

perfectly with Ireland’s vision of its future as a knowledge-led economy.

Why is Dundalk such an ideal location for such an industry?

The requirements of the international BioPharma manufacturing industry include the

availability of a highly skilled workforce; a stable industrial and business environment;

access to key markets and suppliers through a sophisticated transport and logistics

infrastructure; proximity to leading third level education institutions; and the availability

of a suitable site with the right support infrastructure. Dundalk is in an excellent position

of being able to supply all of these and, with the establishment of the IDA Dundalk Science

& Technology Park, the region is now in a position to attract a world class BioPharma

facility to the area.

What happens if an IDA client company decides that it wishes to make changes

to the design of the facility? Is it too late to have an input at that stage?

Any changes to the design of the facilities envisaged in the IDA Ireland planning

application will require a further planning application to seek approval for any alteration or

amendments to the planning permission granted. This separate planning application will

be submitted to the local planning authority and be subject to the full planning process.

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Head OfficeIDA IrelandWilton PlaceDublin 2Ireland

Tel: + 353 1 603 4000Fax: + 353 1 603 4040Email: idaireland@ida.ie

Regional Offices

DundalkFinnabair Business ParkDundalkCo LouthTel: + 353 42 9354410Fax: + 353 42 9354411Email: idaireland@ida.ie

SligoFinisklin Business ParkSligoTel: + 353 71 9159710Fax :+ 353 71 9159711Email: idaireland@ida.ie

LetterkennyIDA IrelandPortland HousePort RoadLetterkennyCo. DonegalTel: +353 74 9169810Fax: +353 74 9169801Email: idaireland@ida.ie

CavanIDA Business Park Dublin RoadCavanTel: +353 49 4368820Fax: +353 49 4332047Email: idaireland@ida.ie

GalwayMervue Business ParkGalwayTel: +353 91 735910Fax: +353 91 735911Email: idaireland@ida.ie

IDA Ireland Offices

CorkIndustry HouseRossa AvenueBishopstownCorkTel: +353 21 4343 555Fax: +353 21 4800202Email: idaireland@ida.ie

WaterfordWaterford Business & Technology ParkCork RoadWaterfordTel: +353 51 333055Fax: +353 51 333054Email: idaireland@ida.ie

AthloneAthlone Business & Technology ParkGarrycastleDublin RdAthloneCo. WestmeathTel: + 353 090 64 71500Fax: + 353 090 64 71550Email: idaireland@ida.ie

LimerickIDA IrelandRoselawn HouseNational Technology ParkLimerickTel: +353 061 200513Fax: +353 061 200399Email: idaireland@ida.ie