Histology of Digestive System Glands

8/12/2019 Histology of Digestive System Glands

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HISTOLOGY of DIGESTIVE SYSTEM

Glands

Ageng Brahmadhi


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Overview

major salivar glands

!aro"id#

s$%mandi%$lar# and s$%ling$al glands

"he !an&reas#

liver

gall%ladder


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'e&all gas"roin"es"inal

glands()


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SS*in

V

Vermillion OOral m$&osa

MM$s&le

GA&&) Salivarglands


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von Ebner's glands


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esophageal glands

aid l$%ri&a"ion

!roen+me

pepsinogen

"he an"i%a&"erial agen"lysozyme.


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Gas"ri& glands

S$rfa&e,lining &ells

M$&o$s -e&* .ells

'egenera"ive /S"em0

.ells

1arie"al /O2n"i&0 .ells

.hief /3mogeni&0 .ells D-ES .ells /A14D or

En"eroendo&rine .ells0


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Brunner's glands


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Overview

major salivar glands

!aro"id#

s$%mandi%$lar# and s$%ling$al glands

"he !an&reas#

liver

gall%ladder


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Overview

Salivar glands

Tas"ing food# ini"ia"e diges"ion# degl$"i"ion# lso+me# la&"oferrin# "he

se&re"or imm$noglo%$lin IgA)

1an&reas

!rod$&es en+mes for "he diges"ion of fa"s# !ro"eins# and &ar%ohdra"es

sn"hesi+es and releases hormones#

ins$lin# gl$&agon# soma"os"a"in# gas"rin# and !an&rea"i& !ol!e!"ide

Liver

me"a%olism of !ro"eins# li!ids# and &ar%ohdra"es

%lood !ro"eins and &oag$la"ion fa&"ors5 man$fa&"$re of vi"amins5 and

de"o2ifi&a"ion of %lood,%orne "o2ins


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The major salivar glands

Parotid, sublingual, and

submandibular

Bran&hed tubuloalveolar

glands

.onne&"ive "iss$e &a!s$le

se!"a lo%es and lo%$les

Ea&h of "he major salivar

glands has a secretory and

a duct portion


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Salivar Glands

Secretory Portions

&om!osed of "hree "!es of &ells

Serous cells

Mucous cells

Myoepithelial cells

Duct Portions

in"er&ala"ed d$&"ss"ria"ed

d$&"sin"ralo%$lar d$&"s

in"erlo%$lar d$&"s in"ralo%ar

and in"erlo%ar d$&"s

1rin&i!al d$&"


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1aro"id Gland

The largest of the salivary glands

Produces about 30% of the total salivary

output Ptyalin and se&re"or IgA

.om!osed mainl of sero$s &ells

Serous + mucous component


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1aro"id Gland


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S$%ling$al Gland

"he smalles" of "he "hree major salivar

glands

!rod$&es onl a%o$" 67 of "he "o"alsalivar o$"!$")

&om!osed of m$&o$s "$%$lar se&re"or

$ni"s &a!!ed % a sero$s &ellssero$s

demil$nesse&re"e lso+me


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S$%ling$al Gland


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S$%mandi%$lar Gland

Produces 60% of the total salivary output

Manufactures a mied saliva, the ma!or

portion is serous The &onne&"ive "iss$e &a!s$le of "he

s$%mandi%$lar gland is e2"ensive

a%$ndan" se!"a


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S$%mandi%$lar Gland


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1an&reas

'e"ro!eri"oneal gland

86 &m long# 6 &m

wide# and 9 "o 8 &m

"hi&*# and i" weighsa!!ro2ima"el 96: g

"lands

#ocrine

#ndocrine


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Se&re"or !or"ion

acinar cell

!ramid# %asall lo&a"ed

ro$nd n$&le$s

The a!e2 of "he &ell

zymogen granules

The %asal &ell mem%ranes

re&e!"ors for "he hormone

cholecystokininand for "he

ne$ro"ransmi""er

acetylcholine


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D$&" !or"ion

D$&" !or"ion

in"er&ala"ed d$&"s

intralobular ducts

interlobular ducts mainpancreatic duct bile

ductpapilla of Vater

&en"roa&inar &ells

Bo"h has re&e!"or forse&re"in ; acetylcholine


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1an&reas Low,mag


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A&inar &ells

!an&rea"i& amlase# !an&rea"i& li!ase# ri%on$&lease#

deo2ri%on$&lease /D-ase0# and "he !roen+mes"r!sinogen# &hmo"r!sinogen# !ro&ar%o2!e!"idase# and

elas"ase# trypsin inhibitor

effe&"ed %

cholecystokinin acetylcholine

The &en"roa&inar &ells and in"er&ala"ed d$&"s

man$fa&"$re a sero$s# %i&ar%ona"e,ri&h al*aline fl$id

effe&"ed % se&re"in


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Endo&rine 1an&reas

spherical aggregates of cells,

$non as islets of &angerhans

ells omposing the !slets of

"angerhans %e"a /


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#he cells of the islets of "angerhans produce insulin$ glucagon$

somatostatin$ gastrin$ and pancreatic polypeptide


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a0 Be"a &ells /la%eled

for ins$lin0

%0 Al!ha &ells /la%eled

for gl$&agon0

&0 Del"a &ells /la%eled

for soma"os"a"in0

d0 11 &ells /la%eled for!an&rea"i&

!ol!e!"ide0


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Liver $n&"ions C

forma"ion and se&re"ion of bile)

s"orage of glycogen# %$ffer for %lood gl$&ose)

sn"hesis of urea)

me"a%olism of cholesteroland fa")

sn"hesis and endo&rine se&re"ion of man plasma proteins# in&l$ding

&lo""ing fa&"ors)

deto%ificationof man dr$gs and o"her !oisons)

&leansing of %a&"eria from %lood)

!ro&essing of several steroid hormonesand vitamin D)

volume reservoirfor %lood)

&a"a%olism of hemoglobinfrom worn,o$" red %lood &ells)


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Liver Organi+a"ion


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Liver Organi+a"ion


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Liver Organi+a"ion


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Liver Organi+a"ion


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Liver Organi+a"ion


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.lassi&al lo%$les

%lood flows from "he

!eri!her "o "he

center of the lobule

in"o "he &en"ral vein Bilebile canaliculi$

periphery of the

lobule"o "he

in"erlo%$lar %ile d$&"sof "he !or"al areas


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1or"al lo%$les

all he!a"o&"es

deliver "heir %ile "o a

!ar"i&$lar in"erlo%$lar

%ile d$&" &ons"i"$"e alo%$le


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He!a"i& a&in$s

%ased on %lood flow from "hedis"ri%$"ing ar"eriole

on "he order in whi&h he!a"o&"es

degenera"e s$%se@$en" "o "o2i& or

h!o2i& ins$l"s

+one # is "he mos" o2gen,!oor)The remaining region is divided

in"o "wo e@$al +ones /9 and 805

+one 9 is "he ri&hes" in o2gen


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four layers

epithelium, lamina

propria, smooth

muscle, andserosaadventitia

simple columnar

epithelium


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Parotid &lands

(

)


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Submandibular gland

()


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Parotid &lands


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Submandibular glands


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End Of Le&"$re

Histology of Digestive System Glands

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