Ruxolitinib reverses dysregulated T helper cell responses ...
Helper t cell 17
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Transcript of Helper t cell 17
Helper T Cell-17
(STAT3)
(STAT5)
“Regulatory T Cell”
“Autoimmune Disease”
Sakaguchi S et al. Immunologic Self-Tolerance Maintained by Activated T Cells Expressing IL-2 Receptor α-Chains (CD25).J Immunol. 1995.
Langrish CL et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation.JEM. 2005.
Figure 1. T cells and inflammatory macrophages enter the CNS of MOG-immunized IL-23p19 mice. (A) Phenotypic analysis of CNS-infiltrating cells in the brains of WT and IL-23p19 mice at day 7 (before EAE onset) after immunization with MOG/CFA. (B) Intracellular cytokine staining of day 7 CNS-infiltrating cells from WT and IL-23p19 mice after 18 h of stimulation with 100 μg/ml MOG peptide, all plots are gated on live CD4 T cells. Data are representative of five separate experiments.
Bettelli E et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.
Nature. 2006.
Figure 1 | Inhibition of T reg development by different cytokines.
Figure 2 | Cytokines required for the generation of TH 17 cells.
Figure 3 | Reciprocal expression of Foxp3
and IL-17 in T cells during differentiation.
自己免疫疾患
第弐拾九話
多発性硬化症(Multiple Sclerosis, MS)
・空間的多発
・時間的多発
・MBP(Myelin Basic Protein)
・オリゴクローナルバンド
関節リウマチ(Rheumatoid Arthritis, RA)
クローン病(Crohn’s Disease, CD)
潰瘍性大腸炎(Crohn’s Disease, CD)
分子標的療法
・インフリキシマブ (メミケード ® ) → 抗 TNF-α 抗体
・リツキシマブ (リツキサン ® ) → 抗 CD20 抗体
・トシリズマブ (アクテムラ ® ) → 抗 IL-6 抗体
・ゲフェチニブ (イレッサ ® ) → 選択的チロシンキナーゼ阻害剤
・?ズマブ (? ® ) → 抗 IL-17 抗体?
人類
補完計画
つづく