Gut Dysbiosis treatment

8/13/2019 Gut Dysbiosis treatment

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Peter Bennett NDMeditrine Clinic,

Langley, BC


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Card

iology

Oncology

Neu

rology

Rheu

matology

Gastro

enterology

Clinical Application

Gut Dysbiosis And The Brain

Case History: Tyler

Intestinal Permeability

Gut Ecology

Cleaning The Blood

Nutritional and Lifestyle Factors That Damage Circulation


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Associations Between IntestinalProblems & Systemic Illness

! Malnutrition (Malabsorption/maldigestion)

! Skin disease (endotoxin, infection)

! Allergies (protein)

! Neurological/behavioral problems (fungal

or bacterial organic acids)

! Joint disease (antigenic cross-reactivity)

Gut Ecology


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If gut ecology is unhealthy, itaffects every other system in

the body.To heal gut dysbiosis, usedetoxification plans offasting, diet modificationand supplementation.

Gut Ecology


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!Bacteria exceed the total number of cells inthe body.

!Total of 3 pounds of bacteria in the gut.

!

A complex interdependent ecosystem

system.

!Four hundred species of bacteria in our GItract.

!Bacteria are beneficial and dangerous; bothcompete for dominance.

!Good bacteria outnumber the bad and makenatural antibiotics.

Gut Ecology


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Acute and Chronic Diseases FromAltered Gut Ecology

!rheumatoid arthritis

!colitis

!diabetes

!meningitis

!myasthenia gravis

!Graves disease

!Hashimotos thyroiditis

!bowel cancer

!food allergies

!eczema

!psoriasis!acne

!urticaria

!migraine headache

!ankylosing spondylitis

!systemic lupus erthematosis

!Crohns disease

!otitis media

!sinusitis

!asthma

!premature labor

!peptic ulcers

!premenstrual syndrome

!cystitis.

Gut Ecology


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Gut Romp

A bacterial imbalance:

!allows harmful bacteria and yeast to multiply

uncontrollably.!injures the membranes that line the intestines,

allowing undigested food products and othercontaminants to leak into the bloodstream

!Alters local detoxification ability

!leads to the production of dangerous chemicals.

Gut Ecology


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Gut Romp500 to 1,000 kinds of bacteria reside in thegastrointestinal (GI) tract

Bacteriodes thetaiotaomicron: more than 1,000 times asabundant as Escherichia coli.

!breaks down indigestible complex carbohydrates intoeasily absorbed sugars

!produces vitamins

!can turn on specific intestinal genes to promote thegrowth of blood vessels necessary for the gut's function

!trigger production of a chemicals that kill competing

bacteria

Gut Ecology


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Gut Romp

Germfree rodent:

!

must consume about 30 percent morecalories to maintain its body weight

!unusually susceptible to infections

Hooper, L.V., and J.I. Gordon. 2001. Commensal host-bacterialrelationships in the gut. Science292(May 11):1115-1118.

Gut Ecology


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the hosts physiology is the result ofinnumerable interactions that should notbe considered as the autonomous piecesof a puzzle but rather like the result ofsubtle equilibria between changingcomponents:species, age, physiologicalstate, gender, diet, environment, intestinalbacterial populations and even stress.Simopuolos AP, et al.(eds) Intestinal Flora, Immmunity, Nutritionand Health. World Rev Nutr Diet. Basel, Kerger, 1193, vol74,123-148.

Gut Ecology


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Autointoxication resurfaces from the 19th centuryhealth culturists as endotoxins. Endotoxemia has now

gained favor as an explanation for the multiple organfailure with severe trauma and sepsis.

Editorial. Intestinal endotoxins as mediators of hepatic injury-an idea whose time has come again. Hepatology 1989:10(5) :881-891.

Gut Ecology


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Endotoxin:

!occurs in the cell walls of of gramnegative bacteria.

!lipopolysaccaride (LPS) is a sugar and fatmolecule.

!cause cell membrane peroxidation.!unchecked, lipid peroxidation results in

massive cellular damage.

!lipid peroxidation causes aging,mutagenisis, carcinogenisis, changes influidity of membranes, necrosis, oxidativehemolysis of red blood cells.

Gut Ecology


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.systemictranslocation of theseenteric bacteria andendotoxin plays a majorrole in the developmentof multiple organ

failure.

Gut Ecology

Deitch EA, et al. Bacterial translocation from the gut impairs systemic immunity. Surgery;109(3):269-276, 1991


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!Endotoxins(LPS) can transit the gut.

!involved in multiple organ failure with severe trauma and

sepsis.

!has been clearly associated with Crohns and neonatal

enterocolitis.

!LPS is scavenged by Kupffer cells, then depresses p450, and

impairs mitochondrial function.

!LPS induces complications in chronic liver disease.

!alcohol aggravates LPS toxicity.

!the Indican teat and microclot generation test determine

endotoxin load.

!selenium and vitamin E deficient diet cause enhanced lipid

peroxidation.

!patients with food sensitivities and environmental

sensitivities suffer from endotoxemia..

Gut Ecology


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Cardiology

On

cology

Neu

rology

Rheu

matology

Gastroenterology



Case History: Tyler


Gut Ecology

Cleaning The Blood



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nProlonged Fasting

nLow dietary fiber

nChemotherapy

nNutritional insufficienciesszincsvitamin Asfolate



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Roles in The GI Tract

! Mouth

!

Stomach- HCL, mucus production! Small Intestine- secretion of

pancreatic enzymes triggered byvagus nerve and duodenalhormones (secretin/cholecystokinin)

! Large Intestine- water absorption,

anaerobic fermentation of SCFA



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Roles of HCL

! Rate limiting step in digestion

!

Activates pancreatic enzymes! Prevents bacterial overgrowth

in SI

! Activates mineral absorption

! Sets the tone for gut ecology



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Typical HypochlorhydriaPicture



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Roony PJ, et al. A short review of the relationshipbetween intestinal permeability and inflammatory

joint disease. Clin Exp Rheum 8:75-83, 1990

the gut is likely thesource of the antigenscausing inflammatoryarthritis.



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Carini C, et al. Immune complexes in food inducedarthralgia. Ann Allergy (59) Dec, 422-428

IgG and IgE antibodieswere high in patients witharthralgia, in the serum andthe synovial fluid ascompared to normals.



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Carini C, et al. Immune complexes in food induced arthralgia. Ann Allergy (59) Dec, 422-428, 1991

Intestinal permeabilitytesting is a successfulmethod to determine truefood allergy.



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Car

diology

On

cology

Neurology

Rheumatology

Gastr

oenterology



Case History: Tyler


Gut Ecology

Cleaning The Blood



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The Gut/Liver-Detoxification

First pass breakdown

Gut-hepatic circulation

Filters blood and sewage

Removal of bacterial toxin

Cleaning The Blood


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Body FatBurden

(Stored toxins)

xxLeaky Gut

Alteration of Organ SystemFunction and/or Structure

4R Program Remove Replace Reinoculate Repair

Liver Detoxificationand Ongoing HepaticNutritional Support

Nutritional SupportResults in Organ SystemDysfunction

Possible Causes

oxidantstress

Liver Burden and AlteredHepatic Detoxification

Genetic State

Nutritional History

Current Nutritional Status

Toxin Burden

MitochondrialDamage

Toxins

Toxins

Eliminated inurine and feces

Body Fat Reduction

Program(Released of stored

toxins)



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Specific food residues arebroken down by thecolonic microrflora with theproduction of chemicals,which, in susceptibleindividuals with low

concentrations of relativehepatic enzymes, pass intosystemic circulation toproduce distantsymptoms.

Cleaning The Blood


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Western Diet And DiseaseCleaning The Blood


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Cleaning The Blood


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+++ Beta-Glucuronidase

Cleaning The Blood


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+++ Beta-Glucuronidase

Cleaning The Blood

Study links antibioticsand breast cancer

Women who took themost antibiotics (morethan 25 prescriptions)

faced double the risk ofdeveloping breastcancer over 17 years,


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Cardiology

On

cology

Neurology

Rheumatology

Gastroenterology



Case History: Tyler


Gut Ecology

Cleaning The Blood


C Hi t T l


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06/06/02Tyler21yo WM

Dx with autismMEDS:

after seizuresto prevent multiple seizures. On Ativan for 6 years. Tried notgiving him the Ativan in Dec/01 and he had 3 seizures within 24 hrs.

(valproic acid) anti seizureTested for fragile X, neg. Hx of family of other kids with learning disabilities.A lot of anxiety disorders on mothers side.Seizures onset age 1.5. Step-mother has known him since age 10. Put on tegretol justbefore seizures. Parents separated at age 10. Last seizure was 1 week ago. Now,seizures 1-2 weeks apart. Typical time is as he is going to sleep or waking, usually itis in the morning. After seizure, he is incontinent at noon for about 24 hrs. Bothbowel and bladder.Seizure early in the morning after getting up to urinate, dropping off to sleep. Whenhe perseverates on something. When he was kneeling watching a CD go around.Used to scrape the letters off yogurt containers for hours. So active throughout theday now, more interactive now.He did his own program at high school. He has also done the Sunrise program whenhe was 16. His seizures were down to 56 weeks apart.Interaction was better, less anxiety. Total attention.

He talks about his seizures, likes the dramatics.

Case History: Tyler

C Hi t T l


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06/06/02TylerDARK SIDE: major aggression in high school, at home. He tried to push her down thestairs. Hit Gail over the head. His mother used to hit him. He slammed his cup of teadown on the counter. Told him to calm down. He looked like he would throw thingswhich he has done. He does not like to be told what to do.1 week ago was verbally abusive, he has a good memory. He started to yell at us. Ihave learned to leave. He threw a can at father.Has a new Neurologist, told to increase the tegratol, he became more aggressive.Especially with the young woman who works with him after work, did not want to go

for a walk. He actually hit co-worker in the van, it was the medication. Took him offthe medication and he is fine.O/ 100/65Heart rrrT: redNo cerv nodesP: deep

PRESEIZURE: tired, irritable. Like to repeat things you say to irritate you. Step-mother has watched his diet after she read about autism and sugar. He tested highon sugar and given a mineral supplement. Once he tested high on all the things heate. Always high in corn and sugar.

Case History: Tyler

Case Histor T ler


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06/06/02Tyler

8:30-6. No bad dreams.he is quite shaky. Hand tremor.on a good diet. Off wheat corn, sugar.

well, no dreams.Seizures last 30 seconds, then he goes through snoring, then he sleeps. Can't talk for10 min. His head will turn sideways and he won't answer. Parents take his glasses offand puts him on the ground. Thrashing, full tonic/clonic, Grande Mal.Possible autism from immunization. First seizure when he was in Courtney.Grandmother remembered that he had just had his immunization. Since birth cried alot. Had a difficult birth, forceps. Treated with cranial.Has scoliosis (typical with autism).

His hair changed when stopped sugar.FHXFather 53 good healthMother 50 low thyroid.Sister good health

Tyler talks to all the secretaries.

P/ Organic acids, amino acids, food allergy

Case History: Tyler

Case History: Tyler


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GI Diagnostic Testing

! Fatty acid analyis

! Food allergy testing

! B12 levels

! CDSA

! Candida testing

! Breath hydrogen

! O+P

! Urine amino acids

! Cortisol and DHEA

! Gastric pH

! Intestinal permeability

! Hair analysis

! Organic acid analysis

! Stool Culture

! Helicobacter

Case History: Tyler

Case History: Tyler


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Ethylmalonate 18.7-drug inducedcarnitine might be helpful

Ineffecient energy producingpathways. Succinate is very high,rare, especailly with fumarate andmalate, this is the heart of citric acidcycle. Indicates CoQ10 inadequateto accept electrons, not makingenough CO Q10. Possible

mitochondrial genetic flaw. Also addB complex.

Low alphaketoglutarate: keymetabolic nutrient, can be drawnaway from mitochondria.

High methylmalonate, very high:(B12) methylcobalamin.

High beta-betahydroxyisovalerate.

Case History: Tyler

Case History: Tyler


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Bacteria and yeast overgrowth,toxins in the body, could befrom giardiacould be yeast.

Case History: Tyler

Intestinal dysbiosis.Case History: Tyler


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Intestinal dysbiosis.Needs B's, folic acid.

Beta-alanaine competes for theretention of taurine. Producedfrom abnormnal bacteria andbreakdown of yeast. Also

Taurine is high. When it is thishigh, it is taurine wasting.Taurine is critical for maintainingintracellular magnesium.

Case History: Tyler

Case History: Tyler


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Case History: Tyler

Case History: Tyler


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Case History: Tyler

Case History: Tyler


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Case History: Tyler


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Cardiology

Oncology

Ne

urology

Rhe

umatology

Gast

roenterology



Case History: Tyler


Gut Ecology

Cleaning The Blood




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GI Function And The Mind

If you talk to God, you arepraying;

If God talks to you, you

have schizophrenia.Thomas Szasz , The Second Sin




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Irritable bowel syndrome, found in 4% to 10% ofthe population, has been associated withpsychiatric illness.

Researchers evaluated 20 patients with IBS andcompared to a control group found 18 of 20patients with irritable bowel syndrome had some

history of psychiatric illness.

One half of the patients with irritable bowelsyndrome met the criteria for panic disorder, whileanother half had social phobia. Major depression,somatization disorder and substance abuse werealso seen frequently in those with irritable bowelsyndrome.

"IBS Patients' Family Has More Mental Illness", Jancin, Bruce,

Family Practice News, May 15, 1994;2.




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Nutrition And The Mind

# Amino Acids From Protein

# Fats From Fish, Seeds and Nuts

# Carbohydrates From Vegetables, Fruitand Whole Grains

# Cofactors From Diet and Supplements

Building Blocks Of Our Thinking




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! Behavior and Learning Disorders

! Depression, Anxiety and Stress

! Memory and Cognitive Disorders




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Neurological

# Neuritis

# Migraineheadaches

# Epilepsy

# Multiple sclerosis

# Alzheimersdisease

# Parkinsons

disease

Behavioral

# ADD/ADHD

# Affective disorders

# Mental illness

# Autism

# Insomnia

# PMS




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Happy Heart=Healthy Intestines




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Adaptation To Chronic Stress InMilitary Trainees

Stress alters the levels of progesterone,estrogen, and thyroxin. In this study it caused:

!increased free salivary cortisol levels!decreased testosterone levels to hypogonadal

levels

!increased salivary DHEA

!insulin insensitivity

!increased gut permeabilityBernton, E., D. Hoover, R. Galloway, and K. Popp. Adaptation to Chronic Stress in Military

Trainees, Ann NY Acad Sci 774 (1995): 21731

y



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Our Intestines Change As We Age:Parietal cells atrophy

HCL secretion decreases

Increased delivery of undigested food to bacterial populations

Altered nutrient absorption

Bacterial populationschange

Increased Clostridia

Decrease in Bifidobacteria


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Gut Ecology


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Ca

rdiology

O

ncology

Ne

urology

Rhe

umatology

Gastroenterology



Case History: Tyler


Gut Ecology

Cleaning The Blood




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If you eat the wrong food..



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ABCs of Gut Health

Enzymes

Soluble fiber

Probiotics

Membrane promoters

No sugar, healthy diet

No food allergies

Healthy heart

M b D l tClinical Application


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Membranes Degranulate

VasoconstrictionBronchoconstrictionVascular permeabilityPlatelet aggregation

Chemotaxis



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Fats On FireCauseCell Membranes To In-flame

VasoconstrictionBronchoconstrictionVascular permeabilityPlatelet aggregation



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Cell Membrane

Arachidonic Acid

(AA)

cyclooxygenase lipooxygenase

Phospholipase A2Quercetin

Quercetin

Curcuma longa

Curcuma longa

potentiatesCortisol

Ginger

Curcuma longa

Quercetin (weak)

Prostaglandins

Series 2

Thromboxane

A2 Leukotrienes

Series 4

Hesperidin/quercetin

Cell membrane stabilizing

Aspirin

Ibuprofen



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Boswellia

Myrrh

blocks lipoxygenase to shut down

inflammation in cell membranes



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Boswellia serrata!Invigorates Blood

!Promotes Qi circulation

!Relieves pain from BloodStasis

!Relaxes sinews, activateschannels

!Reduces swelling

!Promotes healing as avulnerary



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Applications:

!

Trauma!Pain

!Inflammation

!Open sores

!Topical infections

Boswellia serrata



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nActive ingredients: boswellic acidsnInhibits 5-lipoxygenasen82% of patients with ulcerativecolitis went into remission (350mgtid for 6 weeks) compared tosulfsalazine 75%.

Gupta I, Parihar A, et al. Effects of Boswellia serrata gum resin inpatients with ulcerative colitis. Eur J Med Res, Jan,2(1):37-43, 1997.

Boswellia serrataPharmacological Research



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Boswellia serrataPharmacological Research

!70% of patients bronchial asthma dramatically

improved (300mg tid for 6 weeks). Gupta I, Gupta V, et al.Effects of Boswellia serrata gum resin in patients with bronchial asthma:results of a double blind, placebo controlled 6 week study. Eur J Med ResNov 17;3(11):211-514, 1998

!40 patients with Crohns disease were comparedin treatment with mesalazine and it was concludedto be superior in terms or risk vs benefitevaluation. Gerhardt H, et al. Therapy of active Crohns disease withboswellia serrata extract H15. Z Gastroenterol. Ja;39(1):11-17,2001.

Gut Dysbiosis treatment

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