GRIDLOCK by Alvin Ziegler, First Four Chapters

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    GRIDLOCK/Alvin Ziegler 1

    GRIDLOCKA Novel of Suspense

    By Alvin Ziegler

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    Alvin Ziegler

    [email protected]

    148 Alhambra StreetSan Francisco, California 94123

    Telephone: 415.567.5760

    mailto:[email protected]:[email protected]
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    Acknowledgments

    The biggest thanks goes to my wife for her patience. She kept me writing to the

    end. Without her and the sage guidance of my editor/director, Margaret Lucke,

    this story would be lying in a drawer. My technical advisor was the generous

    Josh Bernstein. Aside from fact-checking the story with me in a Peruvian cafe,

    he toured me around Celeras gene laboratory in Alameda, California. Celera, of

    course, sequenced the human genome at a fraction of the cost of the U.S.

    government project.

    The rest of the crew were: my incredible parents, Jean Cartwright, Carole

    Taylor, Martha Jarocki, David Booth, Mark Solomon, Richard Threfall, John

    Houghton, Tom Parker, Nick Booth, Kris Wilhelm, Anne Mahoney, Joanne

    Gomez, Lee Lofland, FBI Gang Unit Chief, George Q. Fong, FBI-trained hostage

    negotiator, Robin Burcell and Jack Bennett, FBI Cyber Supervisor, San Francisco

    Division. A heartfelt thank you goes to those I forgot to mention. The skilled

    videographer who concocted my second book trailer is Nick Mead.

    The timeline, while not literally taken from Wired Magazine, was based on

    an article in the November 17 issue from 2007. Lastly, a number of us will

    never forget our friend, Jerry Tuttle.

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    _____________________________________________

    The Grid is expected to be the next World Wide Web.

    CERN, the Swiss research laboratory that pioneered both.

    "The effort to decipher the human genome . . . will be the scientific

    breakthrough of the centuryperhaps of all time.

    President Bill Clinton, March 14, 2000

    _____________________________________________

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    Facts

    Wherever we go, we carry four billion years of information on humanity. The United

    States Government spent over $2.7 billion on decoding our DNA, but that didnt

    finish the job. Decoding our DNA proved far simpler than interpreting the data that

    it produced so its secrets remained locked.

    Some liken the difference between decoding our DNA and interpreting it to the

    difference between identifying every part of the space shuttle and getting it to fly.

    Unmercifully, the sick and dying have been given a promise that science hasnt

    delivereduntil now.

    A lightning fast computer network called a grid is interpreting our DNA. It can

    solve virtually any question that can be calculated. Using grid technology, scientists

    are creating custom drugs to treat diseases like cancer that are as individual as a

    fingerprint instead of the on-size-fits all approach. This revolutionary advancement

    is reshaping medicine and insurance, changing healthcare forever.

    This book was inspired by actual organizations, technologies, and science.

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    Actual Timeline of the Genome

    Four Billion

    Years Ago

    The beginning of DNA is thought to be created by the

    aggregation of simple, self-replicating molecules in the

    primordial swamp that existed on earth at that time.

    1850s Gregor Mendel, the father of modern genetics established

    the principles of genetic inheritance by studying pea plants.

    1900 Thomas Hunt Morgan, American geneticist discovered the

    basics of dominant and recessive traits and links on a

    chromosome. Awarded the Nobel Prize.

    1950 Barbara McClintock, the worlds most distinguished

    cytogeneticist discovered that chromosomes exchange

    information by jumping genes.

    April 2003 The Human Genome Project, a full map of our genetic code, is

    completed for $2.7 billion in thirteen years.

    December

    2005

    The Cancer Genome Atlasa three-year, $100 million pilot

    project to explore the genetic connections to cancerislaunched.

    May 2007 James Watson's whole genome is sequenced at a cost of less

    than $1 million dollars.

    September

    2007

    Craig Venter publishes the results of his own sequenced

    genome.

    October 6,

    2009

    IBM announces plans to bring the cost of DNA sequencing to

    as low as $100, making a personal genome cheaper than a

    ticket to a Broadway play.

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    one

    Friday, October 28

    Meyrin, Switzerland

    Jurgen rushed from his apartment at 9:45 A.M., tightening his watch strap.

    The silver Mercedes limousine purred at the curb. He climbed into the backseat

    and squeaked into leather upholstery.

    Lets go, Jurgen said through the limo window, lowering the arm rest.

    The limo hummed through the foothills of the jagged Jura Mountains. He could

    see the cerulean blue of Lake Geneva, surrounded by snow-capped peaks that

    extended to the Savoy Alps in France. Cloud wisps swirled over the water as if the

    earth was cooling after its creation. Through the mylar glass, he glimpsed red hair

    beneath the drivers cap.

    Wheres Adrian? Jurgen asked through the limo window.

    Out sick.

    This was no day for bumbling around in the twenty-six cantons of Switzerland.

    You do know the way to CERN?

    Jurgen started to recite the organizations address. The driver cocked her head

    around.

    Yes, Director Hansen.

    At least the limo service had briefed her. The car passed four schoolchildren

    playing tag at a bus stop.

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    Jurgen slid papers from his briefcase. He drummed fingers, studying his talking

    notes. He pictured the faces of executives of the medical community. They had

    flown from around the world to visit CERNsome would be annoyed to find that

    Meyrin was only a glorified agricultural village.

    Jurgen wouldnt let Dr. Onagi bore them today. No. The show stopper would be

    the Grid network.

    He checked the closeness of his shave.

    When the Blackberry in his suit coat vibrated, he scanned Tatianas missive: Im

    wearing Escade perfumesoon that will be all Im wearing.

    He adjusted the knot on his tie, gazing at the road. The limo hugged mountain

    contours as it dropped in elevation.

    A petite redhead who traveled with silk handcuffs and a riding crop awaited

    Jurgen after his speech at CERN. She helped him unwind with sexual role-play. He

    text messaged a reply: Meet me @ Zermatt airport, British Airways, Gate 14, term

    2, 4 PM J. Tonight they would hook up at a chateau high in the Alps where he

    would star in her Russian seductress game. He had made reservations at the luxury

    mountain resort to celebrate the big day.

    Jurgen had picked up Tatiana at a Geneva club two weeks back. He didnt know

    yet how long hed keep hergirlfriend shelf life ran five weeks tops; after that they

    became clingy.

    Shrouded by tinted glass, he reclined against the headrest. As the limo cut

    along the highway, Jurgen envisioned Tatianas lips working his chest. The blare of a

    truck horn pulled him back to reality.

    Looking through the rear window again, his eye caught the Bernese Alpine

    Valley.

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    He hammered on the window divide. Driver.

    There is construction, Sir, the chauffeur said sternly. Were making a

    detour.

    Jurgens watch read ten-thirty. I cant be late.

    Im taking a shortcut.

    Jurgens claustrophobia surfaced.

    The driver veered the limo off the highway. Jurgen felt a nerve flutter. Theyd

    turned onto a side road. Tires grumbled over rocks. The road narrowed, giving way

    to clover and dirt over a canopied path that was no more than a partially paved cow

    trail.

    His mouth went dry. Where are we going?

    Without answering, the driver pressed a button in the glove compartment.

    Jurgen caught that she wore an earpiece.

    Hey.

    The driver rolled up her sleeves. We are close.

    Are you listening?

    The woman hunched at the wheel.

    Holding his Blackberry, Jurgen hit the three-digit Swiss code for emergencies.

    No cell signal. Communications were usually good here.

    The limo halted at the edge of a lake. The driver whipped open Jurgens car

    door.

    Out, the driver ordered.

    Jurgen held the limo handle. What is this?

    The woman leveled a handgun at Jurgens forehead.

    He jerked his hands high, forgetting those visions of greatness. Easy!

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    The clearing had the calm of a cemetery. Watching the unblinking woman,

    Jurgen dropped one foot outside the car, then the other. She had the shoulders of a

    competitive swimmer. What looked like a birth mark covered the left side of her

    face.

    The woman popped open the silver Mercedes trunk with the car key, revealing a

    coil of fishing line and a twenty-pound gym weight.

    Remove the line, the woman ordered. The weight, too.

    As Jurgen picked them up, he heard a buzz from overhead. A twin-engine plane

    a businessman on holiday, perhaps. If only that plane could be Jurgens charter.

    His eyes swept over the wooded lake, grasping at a way out. There were no houses

    within sight.

    So much for being in the land of neutrality.

    The plane noise quieted. A breeze rustled dry leaves past his feet.

    Tie that weight to your leg and knot it tight!

    Cradling the weights against his chest, Jurgen begged, Do you want money?

    Take my wallet.

    That wont be necessary.

    Who do you work for?

    Those who protect us all. She kept the gun trained on his head.

    What about my protection?

    Save your breath!

    He bent and tied, picturing the worst. Time to act. Is this about the Grid?

    Jurgen jerked into a standing position, carrying the weight.

    Hey! The woman shouted.

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    He lunged and hurled the weight at the womans moving head. The weight

    struck her shoulder, knocking her down. She dropped the gun and fell beside the

    weight.

    Jurgen leapt for the gun. With a crawl and grunt, the woman beat him to it. On

    the ground, she pointed the gun and fired.

    He touched the red between his fingers.

    Winded, the woman awkwardly returned to her feet.

    What do you want? Jurgens voice broke.

    She lowered the gun. Get that weight.

    Blood snaked down his arm. He shimmied to the gym weight, pulled it and the

    fishing line toward him with one hand. Aching, he bound it around his ankle.

    The woman brushed dirt from her hat, gesturing for him to get up.

    Jurgen lumbered to his feet, checking his shoulder. Does this involve Jude

    Wagner? Killing me doesnt end the medical revolution. It doesnt change the FDA

    decision.

    The FDA had recently approved genomic drug trials for diabetes patients.

    The womans face hardened. She motioned with the gun muzzle for Jurgen to

    step into the lake. He hesitated then moved into the water. Waist deep, he stepped

    out of his loafers and dove under the algae-covered surface. Underwater, he

    struggled to lose the weight that was tied to his leg. The October sun had failed to

    warm the icy lake.His legs were turning numb and his frozen fingers fumbled with

    the fishing line. His head surfaced.

    Gasping, he heard a blast. In the first nanosecond he felt a sharp tap. In shock,

    he felt no pain but he could no longer fill his lungs with air.

    Another shot slammed into his forehead. Silence. Time stopped.

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    Ripples spread in symmetry above his sinking head.

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    two

    Friday, October 28

    San Francisco, CA

    Aiming his car key button at his Mazda, Jude locked the MX6 on Hyde Street. He had

    found a spot without circling on crammed Russian Hill.

    He passed a family of five parading from an ice cream parlor. The store

    manager followed them out, flipping a closed sign on the glass door. The kids

    giggled at their father when his scoop hit the pavement.

    The scene resurrected a hazy childhood memory. His mother used to carpool

    him and his friends from Little League games to the Baskin Robbins ice cream shop

    after the ninth inning. She would buy a hot-fudge sundae for any batter who got on

    base. She wouldve been proud that her wild-eyed son had become an FBI agent.

    At his ground-floor flat, he pulled out his phone and text messaged his twin

    sister, Kate, Thinking about mom today. SEND.

    He put his phone away, shaking off the effects of bourbon. Kate had told Jude

    that his living alone led to brooding.

    He picked up the New York Times electric blue plastic bag and carried it through

    the front gate to the Mediterranean-styled three-story house. Ruby bougainvillea

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    covered the stucco exterior. Under a trellis of hibiscus, he strode brick steps to his

    door.

    He put the key inside the lock; it cranked too easily. No resistance. The Baldwin

    bolt had already been turned. The idea of calling the cops crossed his mind, but he

    couldve forgotten to lock up. He slowly pushed the door open and moved inside his

    narrow place. The ceiling spotlights in the hallway had been switched on.

    Had he turned them off when hed left that morning? Crossing the living room,

    he made a fist. The bookcase had been emptied. Mystery paperbacks, San

    Francisco history books and rock concert ticket stubs decorated the floor. Papers

    that had been stacked on the rice chest-turned-coffee table were now strewn on the

    oriental rug.

    Maybe the intruder hadnt left. He listened for creaks in the floor.

    Except for wind lashing at the windows, he heard nothing. Not even a fog horn.

    Lightly, he stepped to the kitchen. Open cupboard drawers showed rearranged

    boxes of pasta noodles and chips. In the bedroom, his Chinese dresser doors were

    ajar. Shirts, suits and a high school wrestling trophy had tumbled out on the floor. In

    the mini-study, he checked on his desktop computer. The drive bay was hollow and

    dark, the hard drive missing.

    Cursing to himself, he heard the scuffling of hard-soled shoes from the front

    hallway. Around the corner, a man in a suit kicked open the closet door, then raced

    outside the flat.

    Into draughty air howling off the bay, Jude barreled down the steep grade of

    Filbert Street. Across the gulch, Coit Tower glowed, a beacon in the night.

    The thick-bodied man bobbed in his flapping suit jacket. Practiced at navigating

    the decline, Jude easily tapped down the steps. As the street leveled, he locked on

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    his subject, advancing on his strides. Years of Grid information was stored on that

    hard drive. While Jude usually backed up everything daily, he had failed to do so

    after a breakthrough he had made earlier that day. He regretted not grabbing his

    service weapon from under his bed on the way outa new agent blunder.

    They plowed into North Beach. Jude clipped by Washington Square Park. A faint

    aroma of roasted bean emanated from a closed coffee store. Only ten feet behind

    the man, Jude lunged and brought him to the pavement outside a pizzeria. While on

    the ground, the man gripped the hard drive. With one knee on him, Jude pulled the

    mans arms behind him.

    Call the cops, some voice from the restaurant shouted.

    Im a Federal agent, Jude said.

    The man turned over, breaking free. A Range Rover skidded to a stop. A spry

    woman in a brown jumpsuit hopped out like a hockey player hitting ice. Next, her

    boot pressed into the back of Judes neck, forcing him to asphalt. With her mitt of a

    hand, she snatched the hard drive and papers.

    Jude snagged her leg, sending her to the sidewalk for a time out. The hard drive

    dropped to the ground. Jude intercepted it before he was slugged in the abdomen.

    Elbows tucked, he held the hard drive close and fended off one assailant while

    the other scrambled. But they were out of reach with Jude thrashing, so they

    rammed him in the knees. He went palms and face down onto the pavement.

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    three

    Friday, October 28

    Meyrin, Switzerland

    Alone on the observation deck, Hideo Onagi could almost hear his heart beat. Noise

    travelled easily in this all white chamber, three hundred feet underground, beneath

    the Franco-Swiss border. This was where the famous collider operated. He stared

    glassy-eyed at the bottom of a cavernous, two-story room at the most expensive

    scientific experiment in history.

    His stomach churned. Family turmoil and the gravity of this presentation had

    set off Hideos ulcer. He had arranged to fly to his estranged wife once this was

    over.

    He flipped through 3x5 note cards, reviewing his talking points.

    Returning the cards to his pocket, he felt something else there and took out a

    photo of his daughter, Yomikoage nine and the joy of his life. He gazed at it

    briefly, then pushed it back into his pocket.

    Below, a sort of subway platform served as a maintenance station to the

    monorail that traveled along a twenty-seven-kilometer circumference.

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    Hideos attendees arrived taking in girders and struts which supported the high-

    ceilinged space. The time had come for him to show off the scientific breakthrough

    that took decades to build.

    Two dozen board members and financial officers from the worlds largest

    hospitals and universities had jetted from around the world to this vast lab in

    secluded Meyrin. They looked about, stone-faced, at the consoles that were

    connected by colored wires that lined the walls.

    Hideo tapped his rubber-soled shoe for composure, afraid hed blow his chance

    to get vital donations.

    The history of science had been strewn with great discoveries that were first

    met with cold indifference before acceptance.

    That couldnt happen here. Delay of action on this genome project could cost

    tens of thousands of lives.

    Jurgen, CERNs Life Science Director, should be here. These were his contacts.

    Jurgen said hed handle the walking-tour part of the presentation. Hideo used his

    phone to fire off an unusually direct text message to Jurgen.

    WHERE ARE YOU?

    Although he represented the Stanford University side of things, Hideo was going

    to have to fill in for Jurgen. But Hideos area of molecular biology involved computer

    science, artificial intelligence and biochemistrynot physics.

    At the trial of his life, Hideo was minus the expert witness. These strangers

    would render a pass-fail verdict on work that had consumed him for years.

    Hideo flushed with embarrassment when the consortiumhuddled together as

    a mini United Nationsstared at him. They had come to hear a scholarly revelation

    about how this would change medicine. That would come. First, they had to see

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    what CERNs Grid computer did. Hideo felt like an out-of-town lawyer before a

    restless jury.

    He gestured toward the huge bright blue metal pipe overhead.

    After introducing himself, Hideo said, This pipe runs through a cement-lined

    tunnel that extends in a seventeen-mile subterranean circle. The metal used here

    could build another Eiffel Tower. On the wall beneath the pipe, exotic instruments

    flashed.

    The audience started to chatter.

    As you may know, the Large Hadron Collider is the most powerful accelerator

    in the world, operating at minus two hundred and seventy-one Centigradecolder

    than deep space. Hideo thought a moment, then said, This nine-billion-dollar

    underground linear accelerator was designed to smash protons to analyze the big

    questions of the big bang, cosmologyohand unified theory. Superconducting

    magnets are used to guide protons into a massive collision for observation.

    A fat man interrupted, looking at the tube above. Wait, how does that relate

    Thats coming. Scientists wouldnt have gotten anywhere without a big enough

    computer to analyze all of the data. CERN employed a computer system called a

    grid to study results.

    Attendees murmured, rubbing their arms. He was losing them.

    Fat man said, Like an electrical power grid?

    Not exactly. Computer grids link thousands of computers to work as a single

    virtual machine. This Grid analyzes the equivalent of thirteen million DVDs worth of

    information that the particle collision produces.

    A hawk-faced lady dressed in black: What does this do for healthcare?

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    Hideo spoke with tension in his voice. Were repurposing this world computer

    to analyze the human genomethe total hereditary content of an individual. It

    holds four billion years of information on humanity, the ultimate human recipe book.

    Thats why youre here, to see how your dollars can mine the genome, the greatest

    discovery in scientific history. Interpreting the genome enables us to diagnose every

    disease. You see, the Grid will change society as the Internet did; it will not only

    crunch diagnoses, but will answer anything that can be calculated.

    He paused to let the message sink in and was gratified to see he had eye

    contact.

    The hawk lady pointed skeptically at the flashing instruments. This is how

    youll change medicine?

    Let me explain. CERNs physicists built the Grid to handle questions that are

    exponentially more complex than any computer systems could handle before.

    Conveniently, the Grid runs over the World Wide Webwhich CERN also invented to

    analyze atom-smashing results.

    A technician entered the room below and started electrical equipment.

    Hideo raised his voice to speak over the burring noise, The Grid also powers

    Stanford Universitys research. Its all about distributed processing power,

    connecting computers everywhere to work as one.

    A Persian man in a finely tailored, double-breasted suit said, How will this help

    the general public?

    Im getting to that.

    The hawk-faced woman said, So Jude Wagner isnt speaking today?

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    Hes not. Hideo wrung his hands. He and Jurgen had invited Jude to be

    present for this important meeting, but these days Jude was overbooked. He now

    worked the FBIs Cyber Investigation Squad which demanded his grid expertise.

    Jude had achieved international acclaim for his computer discovery and would

    soon receive the Turing Award from Intel Corporation.

    Lets go to Building Six, Hideo said, Ill explain as we have refreshments.

    Mercifully, Hideo sensed his audience lightening up. With a flick of a CERN tour

    guide flag, he directed them forward.

    He stole a look at his watch. Jurgen was over an hour late. Good god. Could he

    be hung over sick from a night of carousing?

    After an elevator ride to the ground level, they filed to Building Six. While the

    group exchanged hotel stories and restaurant recommendations, Hideo checked his

    phone but saw no messages.

    Hideo led the way to a conference room where attendees ate hors d'oeuvres

    until Hideo motioned for everyone to get comfortable at the rosewood table. Bottles

    of Evian water and folders were set on the table at precise intervals for each

    person.

    The orderly area reminded Hideo of his fastidious wife and their soul-searing

    divorce. His daughters face flashed before him. He moved across the conference

    room to get back to his performance. Jurgens absence had thrown him off.

    Okay. The question from earlier was how this Grid partnership with Stanford

    was going to help the public.

    Yes, came from the Persian man, sipping Evian.

    The goal is to improve everyday medicine using our genomes. The genome is

    our roadmap to understanding disease. All disease has a hereditary basis. Were

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    tapping into that with huge processing power. The U.S. government got us part of

    the way there by sequencing the human genome in 2003, but that was just a start

    and that took 13 years and two-point-seven billion dollars.

    Perspiration soaked his Polo shirt. Hideo fiddled with his wedding ring.

    What does genomic medicine do that traditional medicine cant? The fat man

    asked.

    Traditional medicine is failing. It treats everyone who has cancer with a short

    list of drugs like were all the same. In reality, cancer is as individual as a

    fingerprint. Were talking about one-point-four million people being diagnosed with

    cancer annually in the U.S. alone who are being lumped together with treatment

    that ignores their DNA. Its time we match individual treatment to individuals. Side

    effects from mis-prescription kills over 100,000 Americans a year. he said.

    Genomic medicine will change this.

    How? Hawk Lady asked.

    Once we identify an individuals genome, a world of information becomes

    available to us: a persons body chemistry, his predispositions, his susceptibilities,

    his strengths and weaknesses on a molecular level.

    Hideo took a deep breath.

    By the way, some of this is in your brochure. The Stanford Project works like

    this: a patient has his genome sequenced by a company like 23andMe based in the

    San Francisco Bay Areathis costs around one thousand dollars. The results would

    come back on two DVDs to the patient and his doctor. That doctor could then log

    onto Stanfords secured website to access the Grid. The Grid would compare the

    genomic data from those DVDs against millions of other online medical records,

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    isolating tissue samples from patients with similar symptoms or disease. The result:

    a customized treatment for your individual illness.

    When you combine this Grid that crunches massive amounts of data with

    electronic records from hospitals for instance, well, you end up with a very powerful

    thing.

    The audience had gone dead silent.

    Can you back up? Where do those patient records come from? asked a man

    with a Scottish accent.

    Good question. For years, medical researchers struggled with doing statistical

    analysis. Hospitals, doctors offices and pharmacies used disparate computer

    systems. Thus, networks couldnt communicate, making medical records

    inaccessible. Vital information that could save lives was wasted.

    Finally, research hospitals teamed up with everyone possible to get the data

    online. The solution started with creating systems of security that topped that of the

    ATM business. Of course, even putting anonymous medical information online was

    controversial. Everyone feared the upshot of a privacy breach, but the need to save

    lives won the war over privacy fears. Computer standards were created and

    information pooled. Mind you, all names, social security numbers and hospital

    account numbers remained anonymous. While this was happening, the search

    engines of the world connected that pooled information to create an even larger

    dataset.

    So, whats next? The question came from a man seated at the far end of the

    table.

    Well, already at Stanford, were diagnosing volunteers illnesses through a

    system of comparison, using their DNA. The Grid matches bits of molecular

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    information from tumors with exactly the right drug to suppress that tumor. To treat

    each cancer patient individually means a boat load of analysis. The computer power

    of the Grid makes it possible. In the case of cancer, we fight mutations with custom-

    made proteins that conform to that persons body chemistry.

    Some heads nodded subtly.

    A Persian man asked, Is there someone from CERN who is assigned to this

    Stanford Project?

    I shouldve mentioned, Jurgen Hansen, CERNs Director of Life Sciences, is the

    liaison between this lab and Stanfords. He maintains the physical Internet

    connection which links this Grid to Stanford.

    The Scottish man said, Personalized medicine is a pipedream until we make it

    affordable.

    Hideo stood tall to elongate his short stature. Exactly. Thats the point here.

    Were also in the business of democratizing medicine; making the costly part

    research and diagnosisfree.

    How? the same man interrupted.

    Were leveraging shared computer resources. Not only do grids run over the

    Internet, which is free, but they get power from volunteers idle computers. In the

    packet youll see how this Grid at CERN relies on distributed processing power from

    volunteers.

    I see doubt. Believe me, all we need are the resources. Isnt fighting cancer as

    worthy a mission as landing spacecraft on Mars? If we dont push medicine forward

    1500 Americans will go on dying from cancer every day and thirty-nine million

    people will still have AIDS in Africa because old expensive drugs are failing.

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    Why not invest a fraction of that and get a leg up on the fight against diseases

    like cancer? You can see what a marvel CERNs Grid is if were using it to make

    sense of the Big Bang.

    Audience members turned to one another. Hideo scored a point.

    Looking at his watch, he checked on the time leading to his departing flight.

    I know this is a lot to swallow, but we can agree healthcare in the West is

    disappointing. The Stanford/CERN partnership is testing a non-profit alternative to

    our existing universal healthcare, and we need your support.

    Brochures were being opened when a man entered the room.

    Excuse me for being late. He said.

    While the room was silent the new man found a seat and took the opportunity

    to speak. Apologies if youve already covered this, but what exactly would our

    endowment money accomplish?

    To Hideos relief, eyes tracked him as he circled the table. Your investment will

    pay employee salaries to build Stanfords online service. Your dollars guarantee we

    have processing power from places like CERN. It also extends our Grid to every

    home PCrunning like a worldwide databasebringing supercomputing power to

    desktops, virtually. Well have one enormous virtual super computerthe same

    way researchers from 25 countries analyzed the collision of particles here through a

    Grid of institutions and universities around the world. And, yes, well need specially

    trained pharmacists to mix the customized drugs.

    The room went quiet. After fielding another dozen questions, Hideos mind

    strayed to his flight. His plane was leaving in less than two hours. Barely enough

    time to get to the airport.

    He delivered his plea for investment and thanked everyone.

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    But nothing from Jurgen! Something had to be wrong.

    Still, Jurgens absence hadnt been as detrimental as Hideo had thought. His

    pitch had to have won some new backers.

    Excuse me, everyone, Hideo announced. I have a flight to catch.

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    four

    Friday, October 28

    San Francisco, CA

    A patrol cars P.A. chirp signaled cars to make way. The attackers released Jude as

    the cruiser whipped around the corner and stopped. The man and woman ran to the

    Rover and screeched off.

    On your feet, came from a voice above.

    Flat on his back, Jude flashed back to high school wrestling practice. That vision

    changed when his eyes opened to a bystander and two cops. Three heads

    silhouetted against the night sky. One cop gave a repulsed expression at Judes

    alcohol breath. One strike against him.

    Im with the FBI, Jude choked.

    No response came from the mustached officer. Two cardboard cutouts of men

    wouldve been more animated. After getting on his feet, Jude showed the officer his

    wallet and badge. The bystander vanished into the dark.

    Stand back, the officer said. Jude understood that many cops had been

    treated dismissively by a feeb at some point on duty. That couldve been the case

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    here. It didnt help matters that feds were famous for padding their arrest reports

    with busts made by beat officers.

    What happened here? The younger cop with the flat nose hooked a thumb on

    his belt. Headlights from passing cars reflected in his brass name badge.

    Did you see them? Jude asked, flicking sidewalk dirt from the hard drive; he

    touched blood droplets on his cheek.

    No. Whats your story? The older officer with the bushy mustache picked his

    teeth while he spoke.

    They broke into my place.

    And they were after that . . . computer part? The cop pointed at the hard drive

    that Jude held in his hands.

    The other cop muttered, Thats why youre playing tackle here on Columbus?

    Jude filled them in on the break-in at his apartment and the subsequent chase.

    The uniforms looked to be weighing his tale as one version of the story. The

    younger cop opened a leather-bound notepad and scratched down notes. While the

    officer wrote, Jude removed his cell phone and speed-dialed his colleague, Niles

    Tully. Jude told Niles to come to his apartment and hung up.

    The older officer said, And thats your profession . . . cyber work at the

    bureau?

    Jude nodded. The cop holding his wallet checked his Stanford magnetic

    clearance card.

    Why do you carry a Stanford access card? the cop asked, stroking his

    mustache.

    I consult for them.

    And you work at the FBI?

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    Im on call at Stanforda few hours a weekfor a special project.

    The two cops exchanged glances. Doing?

    Grid computing. Jude avoided elaborating on his role in the genomics

    initiative. What? Dont I look like a workaholic? Jude tapped the hard drive. You

    want a description of the thief, right?

    The cop with the pad filled his page.

    After a quick ride up the hill in the squad car, the three of them trod through

    Judes hallway. The mustached cop gathered loose paper from the floor, leafed

    through them.

    Arent you going to have a team dust for latents? Jude asked.

    Youve got your computer equipment now, right. Can you prove they got

    anything else? Jude sighed audibly.

    Then its only breaking and entering, isnt it?

    Not seeing anything else missing and holding the recovered hard drive in his

    hot hands, Jude knew hed have to check prints for himself. When one said to the

    other, time for a code seven Jude got that they were signaling to eat and their short-

    lived inspection was done. Fearing a lecture on the risks of vigilantism in North

    Beach, Jude led the officers to the door.

    After locking the door behind the cops, Jude blew debris from the hard drive

    with a can of compressed air and slid it into the drive bay. Then he navigated to

    drive F to check for damage. With relief, he saw the files. The pounding in his chest

    slowed, but he couldnt forget that whoever instigated this had dangerous ideas and

    an elaborate plan of operation.

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    He went to the kitchen, pulled a bag out of the freezer and rubbed Birds Eye

    frozen corn on his still raw, throbbing cheek. Moving to the bathroom mirror, he

    stared at scrapes from road burn that textured one side of his face.

    Jude straightened things to cool down. While gathering his concert tickets,

    Wiredmagazines, auto insurance papers and bank statements off his living room

    floor, he realized a folder of business documents that had been resting on his desk

    were gonethe documents that pertained to the Google deal. His nerves shot up

    again. It took months of negotiations to strike the Google deal. He considered

    calling in a stolen property claim. But the Stanford team had taken an oath of

    secrecy about the Google deal, so he didnt.

    If Judes team proved they could genetically diagnose disease over the Internet,

    using the Grid, they would forever change drug treatment; most of the public knew

    this.

    What Stanford hadnt made public was how their impending deal with Google

    would connect the Grid to Googles world databases. This would extend Stanfords

    reach to millions of new electronic patient records for free in exchange for online

    advertising.

    The Google deal had been shrouded in secrecy since the initial negotiations

    because it threatened conventional medicine, the biggest industry in the world.

    Such medicine relied on blockbuster drugs, one-size-fits-all treatments.

    Blockbusters earned the pharmaceutical industry $234 billion annually. This new

    partnership would change the pharmaceutical landscape overnightcustom-

    tailored drugs could now be made very cheaply. Well aware that this relationship

    would cause a ripple effect across industries, the P.R. teams at Google and Stanford

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    had recommended a big bang announcement with no leaks that give lobbyists

    forewarning.

    The Stanford team wanted to be tactful about how they announced that

    custom-tailored drugs could be made very cheaply. Jude had planned on delicately

    breaking the news at his award ceremony without mentioning Google.

    The days where corporations had total control over healthcare could be ending.

    The Grid even had promise for curing cancer, but the initiative wasnt water tight.

    The company heads of Googleplex were ready. Not only had they organized the

    worlds printed information, but they could query medical records on the flyand

    not just view-only records but live data.

    Jude text messaged Kate again, in Kentucky telling her what had happened.

    Setting down his phone, he opened the fridge door and transferred chicken leftovers

    onto a stoneware plate.

    With a chicken leg in hand, Jude heard a knock. After peering through the peep

    hole in the door, he unlocked it. Niles, Judes Grid partner, charged in, smelling of

    cigarette smoke. In a navy pea coat, dress white pants and white bucks, he looked

    as if the British Navy had left port without him.

    Niles slammed the door. Jude locked it behind him.

    Niles studied Jude like he was a caged animal. Your face doesnt look too

    good.

    Jude moved to the living room. Niles followed him, looking at the papers,

    strewn.

    Youre more scattered than a Jackson Pollack painting. Niles said with his

    Oxford English accent, snatching paper from the floor. What happened? Niles took

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    the corner club chair, removed a foil-covered mint from his pea-coat pocket,

    unwrapped it and popped it in his mouth.

    Jude sat on the sofa. They were after my hard drive.

    Blimey. Niles looked around again. Did you see the tosser?

    I saw them all right, but not clearly.

    So, there was more than one. Dont tell me they got away.

    There was only one person in my apartment, and someone came along later

    who helped the thief take off. But they didnt get my drive. Jude touched his cheek.

    What they did get was the Google papers.

    What?

    I suppose they went for whatever they could get.

    Niles got up and walked slowly around the place, staring at the floor.

    Damn it! So, now what? Youll get your bureau on this, right? Ply that job of

    yours. Niles said.

    Jude looked at him, unamused. He knew that Niles resented his leaving Stanford

    for the FBI. Niles felt that he had abandoned the project. It looked that way, but

    Niles shouldve known better. No one was more indispensible to Stanfords genomic

    project than Jude. Officially Jude had changed jobs, yes, but Stanford held onto him

    as their go-to man for algorithm fixes. They had no choice. Judes code was

    embedded in the Grid.

    Niles refused to accept that Judes bureau job benefitted their old team at

    Stanford. But it did. Working at the bureau let Jude study electronic surveillance so

    he could safeguard the Grid against hackers.

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    Losing data about patients would destroy public trusttorpedoing the entire

    medical effort. Jude had become a white-hat hacka hired coder who stopped

    black-hat attacks.

    He recalled how the term hacker originated in the 1950s when a boy called Joe

    Engressia, who was born blind, developed perfect pitch as a result. Being able to

    precisely match a tone of any frequency through singing or whistling, he discovered

    at eight years of age that the U.S. long-distance telephone exchanges responded to

    special frequency tones. The hacker idea came when he saw that the 2600Hz idle

    tone signaled a toll free call. He mimicked that frequency by whistling which

    connected his long-distance call at no charge.

    Intruders could have wanted Judes hard drive to obtain access to the Grid. But

    that wouldnt have helped. Jude carried his key fob in his right front pocket. It held

    the Grid access key. The key displayed a number that changed every thirty seconds

    in sync with the Grid serverenabling Grid access. He may have been cavalier

    about his clothes and car, but not about cryptographic procedure.

    Maybe your secret agent business wont be a waste, after all, Niles quipped.

    Theres gratitude.

    Well call Hideo in the morning. Tell him about the leak. See what he can do to

    protect the Google deal. Niles said.

    I doubt well reach him. After Switzerland, he was flying to Japan.

    Right. Today he gave that funding speech at CERN with Jurgen. Wonder how

    much money that will raise? Regardless, were going to find who nicked these

    papers.

    Im glad youre confident, Jude said.

    Listen, Im knackered.

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    Youre calling it a night?

    Were not going to run through every angle on this thing at a bar. Not at

    midnight. We go at this tomorrow or on Monday, all right? After you get started, call

    me. And keep that head clear. No bevies.

    You are giving a homily on abstinence? Wheres my recorder?

    Judes face brightened with an idea. You working on the boat tomorrow?

    Yes.

    Ill meet you at the marina. We can get a sail in before Kate arrives.

    Niles buttoned his coat, considering it. Okay.

    Niles started for the door. Usual time. And Jude, whoever these low lifes are,

    theyre not going to shut us down.

    Not over my dead body.

    Like you say, healthcares in a quagmire and weve got a duty to see this

    through. But I might reconsider that if I dont get seven hours of sleep. Niles closed

    the door.