The Editor of the Journal of Pharmacology & Experimental Therapeutics wishes to express appreciation to the followingcolleagues who acted as Guest Editors for Specific Fields in 1986.

Martin W. Adler Shri N. Gin Paul L. MunsonLewis Aronow Dora B. Goldstein Larry MuschekMichael A. Beaven Frank R. Goodman Nancy E. OwenC. Paul Bianchi A. James Hance Ronald P. RubinDavid A. Blake Israel Hanin Elaine Sanders-BushDavid B. Bylund Harold F. Hardman Richard ScheifMaynard B. Chenowith Donald Heyneman Lewis E. SeidenTing-Chao Chou Leo E. Hollister Richard E. TesselRonald Y. Chuang Donald J. Jenden Norman J. UretskyTheodore J. Cicero Robert M. Joy Paul M. VanhoutteLeonard Cook Guy C. Le Breton Antonia VernadakisLawrence J. Fischer Ruth R. Levine Martin A. Wasserman

Ray W. Fuller Benedict R. Lucchesi Theodore C. WestGerard L. Gebber K. U. Malik Grant R. WilkinsonJames W. Gibb Donald E. McMillan Henry I. Yamamura

Additionally, sincere thanks are due to 693 of our colleagues not on the Editorial Advisory Board who reviewed articles for theJournal in 1986. Their contributions are acknowledged in the Annual Report of The Journal to the Board of PublicationsTrustees of the American Society for Pharmacology and Experimental Therapeutics.

I 127

INDEX

Volume 241 , April-June, 1987

A23187

leukotriene biosynthesis, coronary arter-ies (dogs, humans), 763

peptidoleukotriene release, lung, high-performance liquid chromatography(guinea pigs), 786

Abernethy, D. R., see Chelly, J. E., 899Acetaminophen

increased liver and kidney damage, obes-ity as risk factor (rats), 921

protein adducts, sensitive immunochemi-cal assay (rabbits), 527

Acetoacetyl coenzyme A thiolase, hypolipi-demic effect, polymethylenemethanethiosulfonates (rats), 1099

AcetylcholineAF64A intraventricular infusion,

changes, synaptic transmission, 181induced vasodilatation, role, endothe-

hum-derived relaxing factor (rab-bits), 516

spontaneous release induced by methyl-mercury, activation of sodium, cal-cium entry (rats), 131

vagal afferent gastric response (cats), 650a1-Acid glycoprotein

enhanced concentration, protein binding,effect of lidocaine (dogs), 289

prazosin elimination (rats), 934Adachi, H., Tomoike, H., Nishijima, H.,

Hayashi, Y., Yamada, A. and Naka-mura M.: Effects of verapamil andnitroglycerin on coronary and sys-temic hemodynamics in consciousdogs, 1072

Adenocarcinoma, lung, disposition,LY256787 and free 4-desacetylvin-

blastine (mice), 695Adenosine

A2 receptor regulation, phosphatidylcho-line secretion, type II pneumocytes(rats), 907

triawloquinazoline, biochemical charac-

terization, 415Adenosine analogs, behavioral and cardio-

vascular effects (monkeys), 76Adenosme triphosphate, P2-purinergic re-

ceptor subtypes, endothelium andsmooth muscle, blood vessels (dogs),

501Adenylate cyclase

activation and binding sites, vasoactive

intestinal peptide, ocular ciliary proc.esses (rabbits), 230

BM 123A effects, heart rate and musca-rinic receptors, myocardium (rab-bits), 804

calmodulin-stimulated, antagonism, tri-

fluoperazine in cerebellar membranes

(rats), 407dietary lipid effects, inotropic responses,

atrium (rats), 838fengabine, effects on cerebral transmis-

sion (rats), 251

parathyroid hormone fragments, calciumtransport, bladder (toads), 448

vasopressin antagonism (monkeys), 797Adrenergic receptors, see AdrenoceptorsAdrenoceptors

a�phaagonist activity, WHR1582A (rats), 97agonist activity of dobutamine, cardiac

output (rats), 861agonists, vasodilator inhibition (dogs),

846postjunctional, differential distribution

(humans), 361pulmonary vasoconstriction, compari-

son (dogs), 6renal, in vivo assessment (rats), 472sensitivity of contraction, receptor a!-

finity (rabbits), 239tissue-dependent activity, buspirone

(rabbits, rats, guinea pigs, dogs), 771

�-1binding in aortas, prazosin (dogs), 875bunazosin, smooth muscle contraction

(rabbits), 1017full and partial agonists, aorta (rab-

bits), 458heterogeneity, brain (rats), 1079, 1092noradrenergic denervation, muscle con-

traction (chicks), 939radioligand binding, potassium efflux

and contraction (rats), 882a�pha-2

anticonvulsant action, muscimol (rats),751

effects of idazoxan, cortical noradrena-line release (rats), 642

noradrenergic suppression, kindling de-velopment (rats), 891

betaagonist8, behavioral effects (rats), 68agonists and antagonists, brain (rats),

755antagonists, alveolar type II pneumo-

cytes, 728antagonists, alveolar type II pneumo-

cytes (rats), 722autoradiographic localization, atrium

(guinea pigs), 1048binding studies, atrium (guinea pigs),

1041dilevalol and, antifibrillatory efficacy

(dogs), 741effect of dietary lipids, inotropic re-

sponses (rats), 838effects of clenbuterol (rats), 187Haemophilus influenzae, trachea

(guinea pigs), 994beta-2, relaxation, isolated human saphe-

nous vein (dogs), 294

effects of antagonists, heart, pheochro-mocytoma (rats), 354

Adrenocorticotropin

release, protein kinase inhibitor, blocked

calcium mobilization, 125

restraint stres8, plasma prolactin re-sponse, nicotine (rats), 438

AF64A, intraventricular infusion, changes

in synaptic transmission, 181AF-DX 116, cardioselective muscarinic an-

tagonist (guinea pigs), 628Ageel, A. M., see Tariq, M., 602Aging

effect, endothelium-mediated relaxation,blood vessels (rats), 387

effect of cimetidine, smoking, theophyl-line and cortisol (humans), 488

Ahlijanian, M. K. and Cooper, D. M. F.:Antagonism of calmodulin-stimu-lated adenylate cyclase by trifluoper-azine, calmidazolium and W-7 in ratcerebellar membranes, 407

Airway, inhalation technique, pharmacoki-netics, cromolyn sodium (humans),1028

Aldosterone, a�pha-1 adrenoceptors, tho-racic aorta, hypertension (rats), 882

Allergy, postanaphylactic phase of inflam-mation, endogenous histamine (rats),967

Alvarado-Garcia, R., see Witkin, J. M., 34Alvares, A. P., see Gondal, J. A., 540Alveolar type II cells, see also Pneumocytes

interactionsbeta adrenergic antagonists, 728beta adrenergic antagonists (rats), 722

Ambrosio, G., see Chiariello, M., 560Amino acids

uptakeparotid gland, lobule system (rats), 655parotid gland, surgical sympathectomy

(rats), 663-y-Aminobutyric acid

fengabineactivity in models, psychopharmacolog-

ical profile (rats), 245effects on cerebral transmission (rats),

251receptor complex, steroid interaction,

structure-activity relationships(rats), 346

tracer-radioactive chloride efflux, cortical

slices (mice), 677Aminoglycosides, induced neuromuscular

blockade, potentiation, protons

(frogs, rats), 686Amitriptyline, antiarrhythmic drugs, use-

dependent effects, cardiac Purkinjefibers (dogs), 282

Amnesia, avoidance behavior, C-terminalfragments, vasopressin and oxytocin(rats), 268

Amphetamine, similar effects, anorectics(pigeons), 817

Amphiphilic drugs, interactions of beta ad-renergic antagonists, alveolar type IIpneumocytes, 728

a-Amylase, amino acid uptake, parotid

gland, lobule system (rats), 655Analgesia

1128 Index

mu opioid receptors, use of $-funaltrex-amine (mice), 374

supraspinal and spinal, mu and detta re-ceptors, (D-Pen2,D-Pen5]enkephalin(mice), 393

Andreasen, F., see Christensen, S., 987Ann, H. S., see Ku, D. D., 961Anorectics, amphetamine-like effects (pi-

geons), 817Antiarrhythmic drugs

lidocaineenhanced a1-acid glycoprotein, protein

binding (dogs), 289interval-dependent effects, cardiac Pur-

kinje fibers (dogs), 275

use-dependent effects, conduction andVmax, cardiac Purkinje fibers (dogs),282

Antibiotics, transport of cefixime, small in-testine, brush-border membrane yes-ides (rats), 594

Anticonvulsant drugs, muscimol, a�pha-2adrenoceptors (rats), 751

Antidepressant drugseffects of clenbuterol and prenalterol, low

response rate, differential reinforce-ment (rats), 68

fengabine, activity in models, psycho-pharmacological profile (rats), 245

Antinociception, levorphanol-induced, se-lective breeding, hot-plate assay

(mice), 477Antiulcer agents, proglumide, cytoprotec-

tive effects (rats), 602

Aorta

alpha-i adrenoceptorscoupling events, full and partial ago-

nists, 458hypertension, thorax (rats), 882prazosin, fl-iodo-[’ThI]-4-hydroxyphenyl-

ethyl-aminomethyl-tetralone (dogs),875

Apelgren, L. D., see Spearman, M. E., 695Apomorphine

acute opiate tolerance, modification of de-velopment, dopamine receptor sensi-tivity (mice), 48

discriminative stimulus, pharmacologicalanalysis (monkeys), 213

Appel, J. B., see Cunningham, K. A., 147Aprindine, cardiac sodium channels, action

potential, ventricular muscles(guinea pigs), 1065

Aquaresis, vaaopressin antagonism (mon-

keys), 797Arachidonic acid, leukotriene biosynthesis,

coronary arteries (dogs, humans), 763Arbilla, S., see Scatton, B., 251Arecoline, nonmuscarinic neurotoxicity, ox-

otremorine (rats), 34Arora, P. K., see Harik, S. I., 669Arteries

digital, postjunctional atpha adrenocep-tors, differential distribution (hu-mans), 361

elastic and muscular, variation in sensi-

tivity, norepinephrine (rabbits), 239

Asano, T., Ikegaki, I., Satoh, S.-!., Suzuki,Y., Shibuya, M., Takayasu, M. andHidaka, H.: Mechanism of action ofa novel antivasospasm drug, HA1077,1033

Aspirin, WHR1582A, gastric antisecretoryand antiulcer effects (rats), 97

Assays

brain slice function, chlorine efflux, �y-

aminobutyric acid (mice), 677enantioselective radioimmunoassay, pen-

tobarbital enantiomers, racemate(humans, rabbits), 779

hot-plate, selective breeding, levorphanol-induced antinociception (mice), 477

immunochemical, acetaminophen-pro-tein adducts (rabbits), 527

Atchison, W. D.: Effects of activation ofsodium and calcium entry on spon-taneous release of acetylcholine in-duced by methylmercury, 131

Atriumbeta adrenoceptors

autoradiographic localization (guinea

pigs), 1048receptor binding studies (guinea pigs),

1041effect of dietary lipids, inotropic re-

sponses (rats), 838left, adaptive supersensitivity, character-

istics (guinea pigs), 453Attention-deficit disorder, children, meth-

ylphenidate, stereoselective disposi-tion, 300

Auranofin, regulation, heme metabolism,liver and kidney (rats), 540

Autoradiography, atpha-1 adrenoceptor het-erogeneity, brain (rats), 1079, 1092

Axons, Myxicola giant, dendrotoxin effects,

potassium and sodium channels, 793

Bache, R. J., see Petein, M., 956Baik, Y. H., see Williams, J. S., 379Balduini, W., Murphy, S. D. and Costa, L.

G.: Developmental changes in mus-

carinic receptor-stimulated phos-phoinositide metabolism in rat brain,421

Balestre, M.-N., see Cory, R. N., 258Balster, R. L., see Beardsley, P. M., 159Balster, R. L., see Rees, D. C., 507

Barbiturates, -y-aminobutyric acid, brainslice functional assay, chlorine efflux(mice), 677

Bar-han, A., see Maren, T. H., 56

Barker, J. L., see Harrison, N. L., 346Barth, T., see Kov#{227}cs,G. L., 569Bartholini, G., see Lloyd, K. G., 245Bartholini, G., see Scatton, B., 251Bay K 8644

characteristics of binding, high and lowaffinity sites, cardiac membranes

(rabbits), 140renin release, kidney cortical slices (rats),

1000

spontaneous release of acetyicholine,methylmercury-induced, sodium ac-tivation and calcium entry (rats), 131

Beardsley, P. M., Balster, R. L. and Salay,J. M.: Separation ofthe response rateand discriminative stimulus effects ofphencyclidine: Training dose as a fac-tor in phencyclidine-saline discrimi-nation, 159

Beardsley, P. M., Scimeca, J. A. and Martin,B. R.: Studies on the agonistic activ-ity of �“-tetrahydrocannabinol in

mice, dogs and rhesus monkeys andits interactions with �9-tetrahytho-cannabinol, 521

Beckeringh, J. J., see IkeZono, K., 294Behavior

Vol. 241

acquisition of conditioned responses, L-PIA (rabbits), 223

avoidance, vasopressin and oxytocin, C-terminal fragments (rats), 268

cardiovascular effects and, adenosine an-alogs (monkeys), 76

discriminative stimulus, apomorphine,pharmacological analysis (monkeys),213

effects of clenbuterol and prenalterol, lowresponse rate, differential reinforce-ment (rats), 68

Belknap, J. K., Danielson, P. W., Laursen,S. E. and Noordewier, B.: Selectivebreeding for levorphanol-induced an-tinociception on the hot-plate assay:Commonalities in mechanism of ac-tion with morphine, pentazocine,ethylketocyclazocine, U-50488H andclonidine in mice, 477

Belpaire, F. M., see De Rick, A. F., 289Bendesky, R. J., see Pendleton, R. G., 110Bennett, T., see Williams, K., 939Benson, R. W., see Roberts, D. W., 527

Benzodiazepine-y-aminobutyric acid, brain slice func-

tional assay, chlorine efflux (mice),677

peripheral-type receptor, interactions ofdiuretics, kidney (rats), 950

Benzphetsmine, amphetamine-like effects,

anorectics (pigeons), 817Berkowitz, B. A., see Ohlstein, E. H., 554Bertko, R., see Willis, R. J., 433Bevan, J. A., see Oriowo, M. A., 239Bevan, R. D., see Oriowo, M. A., 239Beyer, H. S., see Sharp, B. M., 438B-HT 933, a4pha agonists, vasodilator inhi-

bition (dogs), 846Billingham, M. E., see Rosenbaum, J. 5, 354Binapthyl phosphate, enantiomers of threo-

methylphenidate, pharmacology of(rats), 152

1,1-Bis(4-chlorophenyl)-2,2,2-trichloroeth-

ane, free calcium modulation, syn-aptosomes, organochlorine insecti-

cides (rats), 575Bladder, calcium transport, effect, parathy-

roid hormone fragments (toads), 448Blair, I. A., see Thompson, K. A., 84Blood flow

captopril, myocardial infarction and fail-ure (rats), 13

hemodynamic and regional, response topiroximone, congestive heart failure

(dogs), 956hemodynamic effects, isomazole, conges-

tive heart failure (dogs), 20renal a’pha adrenoceptors, in vivo assess-

ment (rats), 472Blood pressure

adenosine analogs, behavioral and cardio-vascular effects (monkeys), 76

central sympathoinhibitory action, ketan-serin, characterization (cats), 736

maintenance of hypertension, sympa-thetic nervous system, pheochromo-cytoma (rats), 870

Blood vesselsendothelium-mediated relaxation, effect

of increasing age (rats), 387postjunctional alpha adrenoceptors, dif-

ferential distribution, limbs (hu-mans), 361

Bloxham, D. P., see Salam, W. H., 1099

1987 Index 1129

Blue, P., see Hank, S. I., 669BM 123A, effects on myocardium, musca-

riitic receptors, adenylate cyclase(rabbits), 804

Bockaert, J., see Cory, R N., 258Bogaert, M. G., see De Rick, A. F., 289Bondy, S. C., see Komulainen, H., 575Bonhaus, D. W., see Platt, K., 751Bowler, J. J., see Wick, P. F., 458Bowling, N., see Hayes, J. S., 861Bower, J. F. and Weiner, N.: Modulation

of the Ca��-evoked release of [3H]dopamine from striatal synapto-

somes by dopamine (D2) agonista

and antagonists, 27Boyajian, C. L, LOUghlin, S. E. and Leslie,

F. M.: Anatomical evidence for alpha-2 adrenoceptor hetemgeneity Differ-ential autoradiographic distributionsof [3H]rauwolscine and [3H]idazoxanin rat brain, 1079

Boyajian, C. L and Leslie, F. M.: Pharma-cological evidence for aipha-2 adre-

noceptor heterogeneity Differential

binding properties of [3Hjrauwol-scine and [3Hjidazoxan in rat brain,1092

Bradykinin, receptor sites, yes deferens(rats, mice, guinea pigs, hamsters),608

Brainalpha-i adrenoceptor heterogeneity, au-

toradiographic distributions (rats),1079, 1092

beta agonista and antagonists, interaction(rats),755

distribution and binding, phenytoin, invitro and in vivo (rats), 704

effect of methamphetamine, neurotensinconcentrations (rats), 443

neurotoxic effects, methylenedioxyme-thylamphetamine (rats, guinea pigs),

338neurotoxicity, 1-methyl-4-phenyl-1,2,3,6-

tetrahydropyridine, mechanisms(rats), 669

opioid receptors, modulation, cannabi-noids (rats), 534

phosphoinositide metabolism, muscarinicreceptor-stimulated, development(rats),421

serotonin uptake sites, in vivo labeling,[3H]-cyanoimipramine (rats), 196

suppression of kindling development, nor-epinephrine, alpha-2 receptors (rats),891

technetium-99m-diethylenetriaminepenta-acetic acid, tyramine neuro-

toxicity (dogs), 42Brandon, D. D., see Kawai, S., 401Braunwalder, A., see Williams, M., 415Breen, T. J., see Bees, D. C., 507Breese, G. it, see Patrick, K. S., 152

Brenner, G. M., see Wince, L C., 838Brodde, O.-E., see Ikezono, K., 294Bronchoconstriction

REV 5901, biochemical and pharmacolog-ical proffle (guinea pigs), 117

U46619-induced, effects of sulfinpyra-zone, platelet activation (humans),623

Brookina, J., see McGonigle, R. J. S., 428Brooks, H. L, see Wynsen, J. C., 846Brtnik, F., see Kov#{225}cs,G. L., 569Brunswick, D. J., see Conway, P. G., 755

Brunswick, D. J., see Wolfe, J., 196Brush-border

cefixime intestinal transport (rats), 594tetraethylammonium transport, effect of

sulfliydryl reagents (rats), 1010Bumol, T. F., see Spearman, M. E., 695Bunazosin, smooth muscle contraction,

proximal uretha (rabbits), 1017Burbach, J. P. H., see de Wied, D., 268Burnstock, G., see Houston, D. A., 501Buspirone, alpha adrenoceptor activity (rab-

bits, rats, guinea pigs, dogs), 771Butler, L. S., see Platt, K., 751Butylpindolol, beta agonists and antago-

fists, interaction, brain (rats), 755Bylund, D. B., see Jones, S. B., 875Bylund, D. B., see Smith, J. M., 882

Caffeineadenosine analogs, behavioral and cardio-

vascular effects (monkeys), 76effects, acquisition, conditioned responses

(rabbits), 223Calcitonin, gene-related peptide, inhibitory

effect on smooth muscles, vas defer-ens (rats), 635

Calciumantagonists, HA1077, pharmacokinetics

(rabbits, dogs, guinea pigs), 1033entry, acetylcholine release, methylmer-

cury (rats), 131entry blockers, enhanced erythropoietin

production, hypoxia (rats), 428free, modulation with synaptosomes, or-

ganochlorine insecticides (rats), 575

glucagon, chronotropic action (rats), 833mobilization, protein kinase inhibitor, an-

terior pituitary tumor cells, 125release of dopamine, striated synapto-

somes, modulation (rats), 27suppression of muscarinic M2 stimula-

tion, histamine H1 receptors, ileum(guinea pigs), 587

transport in bladder, effect, parathyroidhormone fragments (toads), 448

Calcium channelactivator Bay K 8644, characteristics of

binding, cardiac membranes (rab-bits), 140

agonists, ream release, kidney cortical

slices (rats), 1000blockers, correlation, receptor binding

and contractility (rabbits), 91dihydropyridine, role ofendotheium, cor-

onary smooth muscle (porcine), 379Calcium ionophore: see A23187Caldwell, R W., see Patrick, K. S., 152Callahan, P. M., see Cunningham, K. A.,

147Calmidazolium, antagonism, calmodulin-

stimulated adenylate cyclase, cere-bellar membranes (rats), 407

Calmodulinantagonism of adenylate cyclase, trifluo-

perazine, cerebellar membranes(rats), 407

calcium channel agonists, ream release,kidney cortical slices (rats), 1000

Camp, V. M., see Faraj, B. A., 42Canale, E., see Molenaar, P., 1048

Cannabinoidsmodulation, br&a opioid receptors (rats),

534tetrahydrocannabinol, detta-9(11) and

delta-9, agonistic activity (mice, dogs,monkeys), 521

Cannon, P. J., see Piomelli, D., 763Cappelli-Bigazzi, M., see Chiariello, M., 560Captopril, acute regional vascular effects,

myocardial infarction and failure(rats), 13

Carbonic anhydrase, methazola.mide ana-logs, ocular pharmacology (rabbits),56

Cardiac output, alpha agonist activity, do.butamine (rats), 861

Cardiomyopathy, effects of adrenergic re-ceptor antagonists, pheochromocy-toma (rats), 354

Cardiotonics, congestive heart failure,hemodynamic effects, isomazole(dogs), 20

Cardiovascular system, effects, dopamine �-hydrozylase inhibitor (rats), 554

Carter, C., see Dennis, T., 642Casals-Stenzel, J., Muacevic, G. and Weber,

K.-H.: Pharmacological actions ofWEB 2086, a new specific antagonistof platelet activating factor, 974

Cash, W. D., see Williams, M., 415Caster, K. C., see Maren, T. H., 56Catecholamines

AF64A intraventricular infusion,changes, synaptic transmission, 181

alpha-i adrenoceptors, thoracic aorta, hy-pertension (rats), 882

cardiovascular effects, inhibitor, dopa-mine $-hydroxylase (rats), 554

central hyperglycemic action, mechanism,histamine (mice), 582

enantiomers of threo-methylphenidate,pharmacology of (rats), 152

neurotoxicity, methylenedioxymethylam-phetamine, brain (rats, guinea pigs),338

pheochromocytomaadrenergic receptor antagonists, heart

(rats), 354maintenance of hypertension, sympa-

thetic nervous system (rats), 870Caudate nucleus, presynaptic actions of

PCP, in vivo electrochemicalonstration (rats), 714

Cefixime, intestinal transport, brush-bordermembrane vesicles (rats), 594

Central nervous systemalpha adrenoceptor activity (rabbits, rats,

guinea pigs, dogs), 771beta agonists and antagonists, interaction,

brain (rats), 755ketanserin, characterization (cats), 736phenytoin distribution and binding,

brain, in vitro and in vivo (rats), 704Cephalosporin, cefixime intestinal tram-

port, brush-border membrane veal-

des (rats), 594Cerebellum

antagonism, calmodulin-stimulated ade-nylate cyclase, trifluoperazine (rats),407

effects of fengabine (rats), 251interactions of metaphit and phencycli-

dine, sigma agonist (rats), 321Cerebral cortex

inositol phospholipid hydrolysis, acuteand chronic lithium treatments(rats), 1023

noradrenaline release, effects of idazoxan,

1130 Index

presynaptic alpha-2 adrenoceptors

(rats), 642Cerletti, C., see Hatmi, M., 623CGP 28392, renin release, kidney cortical

slices (rats), 1000CGS 13080, phosphodiesterase inhibitor

and, prevention of thrombosis (rab-bits), 855

CGS 15943, biochemical characterization,415

Chang, R. S. L, see Lotti, V. J., 103Chelly, J. E., Hysing, E. S., Abernethy, D.

R., Doursout, M.-F., Hartley, C. J.,Guerret, M. and Merin, R. G.: Roleof isoflurane on hemodynamic prop-erties and disposition of nicardipine,899

Chen, W. Y., see Wince, L. C., 846, 838Wynsen, J. C., Groas, G. J., Brooks,H. L. an, ptor agonists in consciousdogs

Cheng, J. B., Eskra, J. D. and Pillar, J.: Acomparison of antigen and Ca�-ionophore-induced peptidoleuko-

triene release from guinea pig lungpreparations using high-performanceliquid chromatography, 786

Chernow, B., Zaloga, G. P., Malcolm, D.,Wiley, S. C., Clapper, M. and Hola-day, J. W.: Glucagon’s chronotropicaction is calcium dependent, 833

Cherry, P. D. and Gills, C. N.: Evidence forthe role of endothelium-derived re-lazing factor in acetylcholine-in-duced vasodilatation in the intact

lung, 516Chiang, J., see #{248}ie,S., 934Chiariello, M., Ambrosio, G., Cappelli-Bi-

gazzi, M., Nevola, E., Perrone-Fi-lardi, P., Marone, G. and Condorelli,M.: Inhibition of ischemia-inducedphospholipase activation by quina-crine protects jeopardized myocar-

dium in rats with coronary arteryocclusion, 560

Ching, M. S., Mihaly, G. W., Morgan, D. J.,Date, N. M., Hardy, K. J. and Small-wood, R. A.: Low clearance of cime-tidine across the human placenta,1006

Chlordecone, free calcium modulation, syn-aptosomes, organochiorine insecti-cidee (rats), 575

Chlorine, tracer-radioactive efflux, �y-ami-

nobutyric acid, brain slice functionalassay (mice), 677

Chlorisondamine, maintenance of hyper-tension, sympathetic nervous system,pheochromocytoma (rats), 870

2-Chloroadenosine, adenosine A2 receptorregulation, phosphatidylcholine se-

cretion, pneumocytes (rats), 907

1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2,2-trichloroethane, free calcium mod-ulation, synaptosomes, organochlo-rime insecticides (rats), 575

Chlorpheniramine, central hyperglycemic

action, mechanism, histamine (mice),582

Chlorphentermine, amphetamine.like ef-fecta, anorectics (pigeons), 817

Cholecystokininendogenous, role, biliary/pancreatic/gas-

tric function (dogs), 110

L-364,718, in uwo pharmacology (mice,

rats, cats, dogs, rabbits), 103Christensen, S., Petersen, J. S., Steiness, E.

and Andreasen, F.: Dose dependenceofproximal and distal tubular effectsof furOsemide in conscious rats, 987

Chromatography

gas, enantiomers of threo-methylpheni-date, pharmacology of (rats), 152

high-performance liquid, peptidoleuko-triene release, lung (guinea pigs), 786

Chrousos, G. P., see Kawai, S., 401Churchill, S., see Kinter, L. B., 797

Cibenzoline, sinoatrial node preparations,electrophysiological study (rabbits),982

Cieslinksi, L. B., see Kopia, G. A., 174Cigarette smoking see SmokingCimetidine

effect of smoking and, theophylline andcortisol, aging (humans), 488

low clearance, human placenta, 1006Clapper, M., see Chernow, B., 833Claustre, Y., see Scatton, B., 251Clenbuterol

effects, central beta-i and beta-2 adrener-gic receptors (rats), 187

effects on performance, low response rate,differential reinforcement (rats), 68

Chine, W. H., Jr., see Yamamoto, R., 826Clineschmidt, B. V., see Lotti, V. J., 103Clineschmidt, B. V., see Pendleton, R. G.,

110Clonidine

levorphanol-induced antinociception, se-lective breeding, hot-plate assay(mice), 477

maintenance of hypertension, sympa-thetic nervous system, pheochromo-cytoma (rats), 870

Clortermine, amphetamine-like effects, an-orectics (pigeons), 817

Cocaine, periarterial nerve stimulation, en-dogenoua norepinephrine release,mesenteric vasculature (rats), 826

Coffin, V. L and Spealman, R D.: Behav-ioral and cardiovascular effects of an-alogs of adenosine in cynomolgusmonkeys, 76

Cohen, M. L, see Pomfret, D. W., 465

Cohn, J. N., see Petein, M., 956Colon

healthy and inflamed, leukotrienes, che-motactic peptide stimulation (rab-bits), 218

L-364,718, in vivo pharmacology (mice,

rats, cats, dogs, rabbits), 103Commins, D. L, Vosmer, G., Virus, R. M.,

Woolverton, W. L, Schuster, C. R

and Seiden, L S.: Biochemical andhistological evidence that methyle.nedioxymethylamphetamine

(MDMA) is toxic to neurons in therat brain, 338

Condorelli, M., see Chiariello, M., 560Conradi, E. C., see Walle, T., 928Contractility, correlation, calcium channel

blockers (rabbits), 91Convulsions, nonmuscarinic neurotoxicity,

oxotremorine (rats), 34Conway, P. G., Tejani-Butt, S. and Brims-

wick, D. J.: Interaction of beta adre-

nergic agonists and antagonists withbrain beta receptors in vice, 755

Cook, C. E., Seltzznan, T. B., Tallent, C. R.,

Vol.241

Lorenzo, B. and Drayer, D. E.: Phar-macokinetics of pentobarbital enan-tiomers as determined by enantiose-

lective radioimmunoaasay after ad-ministration of racemate to humansand rabbits, 779

Cooke, J. P., see Flavahan, N. A., 361Cooper, D. M. F., see Ahlijanian, M. K., 407Corcoran, G. B. and Wong, B. K.: Obesity

as a risk factor in drug-induced organinjury: Increased liver and kidneydamage by acetaminophen in theobese overfed rat, 921

Coronary arteryhemodynamics, verapamil and nitro-

glycerin (dogs), 1072ischemia-induced phospholipase activa-

tion, inhibition, quinacrine (rats),560

leukotriene biosynthesis (dogs, humans),763

leukotriene D4-induced vasoconstriction,inhibition, leukotriene antagonists

(dogs), 174P2-purinergic receptor subtypes, endothe-

lium, smooth muscle (dogs), 501vasorelaxation, magnesium deficiency

(dogs), 961Corticosterone, periarterial nerve stimula-

tion, endogenous norepinephrine re-lease, mesenteric vasculature (rats),826

Corticotropin-releasing factor, protein Id-nasa inhibitor, blocked calcium mo-bilization, anterior pituitary tumorcells, 125

Cortisolskin absorption (mice), 482theophylline and, effect ofcimetidine and

smoking, aging (humans), 488Cory, R. N., Rouot, B., Guillon, G., Slade-

czek, F., Balestre, M..N. and Bock-aert, J.: The 5-hydroxytryptamine (5-HT2) receptor stimulates inositolphosphate formation in intact andbroken WRK1 cells: Determinationof occupancy-response relationshipsfor 5-HT agonists, 258

Costa, E., see Eva, C., 181Costa, E., see Mocchetti, I., 1120Costa, L. G., see Balduini, W., 421Coutts, S., see Van Inwegen, It G., 117Cowart, T. D., see Walle, T., 928Cromolyn sodium, absorption and disposi.

tion kinetics, influence, inhalationtechnique (humans), 1028

C-terminal fragments, vasopressin and ox-ytocin, avoidance behavior (rats), 268

Cunningham, K. A., Callahan, P. M. andAppel, J. B.: Discriminative stimulusproperties of lisUride revisitedi In-volvement of dopamine D2 receptors,147

Cusack, B. J., see Vestal, R. E., 488[3H]-Cyanoimipramine, in vivo labeling, se-

rotonin uptake sites, brain (rats), 196Cyanopindolol

beta adrenoceptorsautoradiographic localization, atrium

(guinea pigs), 1048binding studies, atrium (guinea pigs),

1041Cyclic AMP

adenosine A2 receptor regulation, phos.

1987 Index 1131

phatidylcholine secretion, pneumo-cyt.es(rats), 907

parathyroid hormone fragments, calciumtransport, bladder (toads), 448

protein kinase inhibitor, blocked calcium

mobilization, anterior pituitary cells,125

Cyclic GMPfengabine, effects on cerebral transmis-

sion (rats), 251phorbol ester-induced inhibition, musca-

nc receptors, neuroblastoma cells(mice), 366

Cyclosporine, low-dose, prophylaxis, non.obese diabetic mice, 1106

Cytochrome P-450aromatic phenytoin hydroxylation, star-

eochemistry, phenotypes (humans),

615hepatic metabolism, tolbutaniide, methyl

hydroxylation, 1112

Danielson, P. W., see Belknap, J. K., 477Date, N. M., see Ching, M. S., 1006

Dawson, G. W., see Vestal, R E., 488Debrisoquine, phenytoin hydroxylation,

stereochemistry, phenotypes (hu-mans), 615

Dedek, J., see Scatton, B., 251de Gaetano, G., see Hatmi, M., 623Deilo, C., see De Rick, A. F., 289del Maschio, A., see Hatmi, M., 623Dendrotoxin, potassium channel blockade,

slowed sodium inactivation, Myxicolagiant axons, 793

Denervationnoradrenergic, alpha-i adrenoceptors,

muscle contraction (chicks), 939parotid gland

lobule system, amino acid uptake (rats),655

surgical sympathectomy, amino aciduptake (rats), 663

Dennis, T., L’Heureux, R., Carter, C. andScatton, B.: Presynaptic ajpha-2adrenoceptors play a major role inthe effects of idazoxan on corticalnoradrenaline release (as measuredby in vice dialysis) in the rat, 642

Dennis, T., see Scatton, B., 251Deoxadrol, interactions of metaphit and

phencydidine, sigma agonist actions,cerebellum (rats), 321

Depenbuach, J. W., see Drexler, H., 13Depoortere, H., see Lloyd, K. G., 245Depression, effects of fengabine (rats), 245,

251De Rick, A. F., Belpaire, F. M., Dello, C.

and Bogaert, M. G.: Influence of en-hanced alpha-i-acid glycoproteinconcentration on protein binding,pharmacokinetics and antiar-rhythmic effect of lidocaine in thedog, 289

4-Desacetylvinblastine, LY256787 and, dis-

position (mice), 695Desipromine, dihydroxyphenyiglycol and

intraneuronal metabolism, norepi-nephrine, vas deferens (rats), 547

Deth, R C., see Wick, P. F., 458de Wied, D., Gaffori, 0., Burbach, J. P. H.,

Kov#{227}cs,G. L. and van Rae, J. M.:Structure activity relationship stud-ies with C-terminal fragments of yes-

opressin and oxytocin on avoidancebehaviors of rats, 268

De Wolf, W. E., Jr., see Ohlstein, E. H., 554Dexamethasone

interactions of beta adrenergic antago-

nistsalveolar type II pneumocytes (rats), 722alveolar type II pneumocytes, 728

Diabetes mellitusa-glucohydrolase inhibitor MDL 25,637,

inhibited disaccharidases, blood glu-cose (rats), 915

low-dose cyclosporine, prophylaxis(mice), 1106

streptozotocin-induced, renal handling,netilmicin (rats), 166

Diazepamamphetamine-like effects, anorectics (pi-

geons), 817nonmuscarinic neurotoxicity, oxotremo-

rime (rats), 34Dickson, C. R., see Richards, R., 1028

Dietary fat, effect ofdietary lipids, inotropicresponses, atrium (rats), 838

Diethylenetriamine penta-acetic acid, tyra-mine neurotoxicity (dogs), 42

Diethylpropion, amphetamine-like effects,

anorectics (pigeons), 817Dihydropyridine, calcium channel modula-

tore, role of endothelium, coronarysmooth muscle (porcine), 379

1,4-Dihydropyridine, calcium channel acti-vator, Bay K 8644, binding in cardiacmembranes (rabbits), 140

Dihydroxyphenylglycol, intraneuronal me-tabolism and, norepinephrine, yesdeferens (rats), 547

DiJoseph, J. F., Bash, J. R., and Mir, G. N.:Gastric antisecretory and antiulcereffects of WHR15S2A, a compoundexerting aipha-2 adrenoceptor ago-

fist activity, 97Dilevalol, beta adrenergic receptor blockade,

antifibrillatory efficacy (dogs), 741Diltiazem, Bay K 8644, characteristics of

binding, cardiac membranes (rab-bits), 140

[1-(2,6-Dimethylphenyl)-3-isobutoxyamidi-noureajhydrochloride, WHR1582A,gastric antisecretory and antiulcer ef-

fects (rats), 97Diaaccharidases, intestinal, blood glucose,

a-glucohydrolaae inhibitor (rats), 915Diuretics, interactions, peripheral-type ben-

zodiazepine receptor, kidney (rats),950

Dobutaminealpha agonist activity, cardiac output, iso-

proterenol infusion (rats), 861compared to piroximone, blood flow re-

sponse, congestive heart failure

(dogs), 956Dopamine

AlO, repeated morphine injection, sensi-tization (rats), 204

alpha adrenoceptor activity, comparison,

pulmonary vasoconstriction (dogs), 6enantiomers of threo-methylphenidate,

pharmacology of (rats), 152enkephalin activation, mu opioid receptor

involvement, ventral tegmental area(rats), 328

increased receptor sensitivity, acute opi-ate tolerance, modification of devel-opment (mice), 48

1-methyl-4-phenyl-1,2,3,6-tetrahydropyr-idine neurotoxicity, mechanisms(rats), 669

presynaptic actions of PCP, in vivo dec.trochemical demonstration, caudate

nucleus (rats), 714receptor subtypes, striatal enkephalin

turnover, 1120release from striatal synaptosomes, cal-

cium, modulation (rats), 27Dopamine �-hydroxylaae, inhibitor, cardio-

vascular effects (rats), 554Doursout, M.-F., see Chelly, J. E., 899Drayer, D. E., see Cook, C. E., 779Drexler, H., Depenbusch, J. W., Truog, A.

G., Zelis, R. and Flaiin, S. F.: Acuteregional vascular effects of intrave-nous captopril in a rat model of myo-cardial infarction and failure, 13

Driscoll, E. M., see Lynch, J. J., 741Drug discrimination

apomorphine, pharamcological analysis

(monkeys), 213phencycidine, separation of the response

rate (rats), 159properties of lisuride, involvement, dope-

mine D2 receptors (rats), 147Duckles, S. P., see Hynes, M. R, 387

Duffy, see Kalivas, P. W., 204Duffy, P., see Latimer, L. G., 328

Bash, J. R., see DiJoseph, J. F., 97Egan, J. W., see Smith, E. F. III, 835Ehiert, F. J.: Effects of an alkylating deny-

ative of oxotremorine (BM 123A) onheart nate, muscarinic receptors andadenylate cyclase activity in the nab-bit myocardium, 804

Eiseman, J. L., see Gondal, J. A., 540Eisenhofer, G., Ropchak, T. G., Stull, R. W.,

Goldstein, D. S., Keiser, H. R andKopin, I. J.: Dihydroxyphenylglycoland intraneuronal metabolism of en-dogenous and exogenous norepineph-nine in the nat vas deferens, 547

Electnophysiology

cibenzoline, sinoatnial node preparations(rabbits), 982

interactions of metaphit and phencycli-dine, sigma agonist actions, cerebel-lum (rats), 321

quinidine, comparison, dihydroquinidine(dogs), 84

El-Fakahany, E. E., see Lai, W. S., 366Enantiomers

disposition of methylphenidate, children,attention-deficit disorder, 300

dobutamine, alpha agonist activity, car-diac output (rats), 861

pentobarbital, pharmacokinetica, race-mate (humans, rabbits), 779

pharmacology, threo-methylphenidate

(rats), 152stereochemistry, aromatic phenytoin

hydroxylation, phenotypes (humans),615

Endotheiumcoronary smooth muscle responses, dihy-

dropyridine calcium channel modu-latons (porcine), 379

smooth muscle and, P2-purinergic recep-

ton subtypes, blood vessels (dogs), 501vasorelaxation, coronary arteries, mag-

nesium deficiency (dogs), 961

Endothelium-derived relaxing factor

1132 Index

dihydropyridine calcium channel modu-lators, role of endotheium, coronarysmooth muscle (porcine), 379

effect of increasing age, blood vessels invitro (rats), 387

role, acetylcholine-induced vasodilation,lung (rabbits), 516

Engels, F., Costing, R. S. and Nijkamp, F.P.:Dual effects ofHaemophilus influ-enzae on guinea pig tracheal beta-adrenergic receptor function: In-volvement of oxygen-centered radi-cala from pulmonary macrophages,994

Enkephalinactivation of dopamine neurons, mu

opioid receptor, ventral tegmental

area (rats), 328turnover, dopamine receptor subtypes,

1120Met-Enkephalin, decreased vascular resist-

ance, intra-arterial injection (nab-bits), 314

J�pileptogenesis, suppression of kindling de-velopment, norepinephrine, alpha-2receptors (rats), 891

Epinephnine, effect of dietary lipids, ino-tropic responses, atrium (rats), 838

Epinine, alpha adrenoceptor activity, com-

parison, pulmonary vasoconstniction(dogs), 6

Epithelial cellsalveolar type II

interactions, beta adrenergic receptors(rats), 722

interactions, beta adrenergic receptors,

728membrane, vasoactive intestinal peptide,

ocular ciliary processes (rabbits), 230

Erickson, R., see Ohlstein, E. H., 554Erythropoietin, enhanced production, cal-

cium entry blockers, hypoxia (rats),428

E�kra, J. D., see Cheng, J. B., 786Estradiol, skin absorption (mice), 482Ethylcholine aziridinium ion, changes in

synaptic transmission, intraventric-ular infusion, 181

Ethylketocyclazocine, levorphanol-inducedantinociception, selective breeding,hot-plate assay (mice), 477

Etorphine, analgesic activity, mu receptorinvolvement, �-funaltrexamine(mice), 374

Eva, C., Fabrazzo, M. and Costa, E.:Changes of choinergic, noradrener-gic and serotonergic synaptic trans-mission indices elicited by ethylcho-line azinidinium ion (AF64A) infusedintraventricularly, 181

Evans, S. M. and Johanson, C.-E.: Amphet-amine-like effects of anorectics andrelated compounds in pigeons, 817

Exercise, captopnil, acute regional vasculareffects, myocardial infarction (rats),13

Eyemethazolamide analogs, distribution, ef-

fects on pressure (rabbits), 56ocular ciliary processes, adenylate cyclase

activation, vasoactive intestinal pep-tide (rabbits), 230

Ezekiel, M., see Ohlstein, E. H., 554

Fabisiak, J. P., Vesell, E. S. and Rannels,

D. E.: Interactions of beta adrenergic

antagonists with isolated rat alveolartype II pneumocytes. I. Analysis,characterization and regulation ofspecific betaadrenergic receptors, 722

Fabisiak, J. P., Vesell, E. S. and Rannels,D. E.: Interactions of beta adrenergicantagonists with isOlated rat alveolartype H pneumocytes. II. Receptor-independent accumulation ofbeta ad-renergic antagonists and other cati-omc amphiphilic drugs in lamellarbodies, 728

Fabrazzo, M., see Eva, C., 181Fading, discriminative stimulus effects,

phencycidine (rats), 159Fanestil, D. D., see Lukeman, D. S., 950Faraj, B. A., Schmidt, F. H., Sarper, R.,

Camp, V. M. and Malveaux, E.: Ty-ramine neurotoxicity and first-pass

brain technetium-99m-diethylene-

triamine penta-acetic acid, 42Fatty acids, effect ofdietary lipids, inotropic

responses, atrium (rats), 838Feinmark, S. J., see Piomelli, D., 763Fenfluraniine, amphetamine-like effects,

anorectics (pigeons), 817Fengabine

antidepressant GABAergic agentactivity in models, psychopharmacolog-

ical profile (rats), 245effects on cerebral transmission (rats),

251Fentanyl, analgesic activity, mu opioid re-

ceptor involvement, �-funaltrexam-me (mice), 374

Ferris, R. M., see Patrick, K. S., 152Fetus, cimetidine, low clearance, human

placenta, 1006Fioni, F., see #{248}ie,S., 934Fisher, J. W., see McGomgle, R. J. S., 428Flaim, S. F., see Drexler, H., 13Flavahan, N. A., Cooke, J. P., Shepherd, J.

T. and Vanhoutte, P. M.: Human

postjunctional alpha-i and aipha-2adrenoceptors: Differential distribu-tion in arteries of the limbs, 361

Fleming, W. W., see Hawthorn, M. H., 453Fludzinski, P., see Pomfret, D. W., 465

Flurothyl, stimulus properties, pentobarbi-tel-like (mice), 507

Foley, J. J., see Kopia, G. A., 174Formby, B., Miller, N., Garret, R. and Pe-

terson, C. M.: Effects oflow-dose cy-closponine prophylaxis in nonobesediabetic mice, 1106

Forakolin, left atrium, adaptive supersensi-tivity, characteristics (guinea pigs),453

Francis, J., see Williams, M., 415Fraser, A., see Ordway, G. A., 187Frey, B. M., see Fritz, S., 615Fritz, S., Lindner, W., Roots, I., Frey, B. M.

and Kupfer, A.: Stereochemistry ofaromatic phenytoin hydroxylation invarious drug hydroxylation pheno-types in humans, 615

Fujita, T., see Shebuski, It J., 6Fujiwara, M., see Tsubomura, T., 650$-Funaltrexamine, mu opioid receptor in-

volvement, analgesic activity, opioidligands (mice), 374

Fura-2, free calcium modulation, synapto-somes, organochlonine insecticides

(rats), 575

Vol. 241

FUrOsemide, proximal and distal tubular ef-

fects, dose dependence (rats), 987

G25671, effects of sulfinpyrazone, plateletactivation, U46619 and bronchocon-stniction (humans), 623

GABA, see �y-Azninobutyric acidGaddis, R. R., see Wightman, J. M., 314Gaffney, T. E., see Walle, T., 928Gaffoni, 0., see de Wied, D., 268Gallbladder, L-364,718, in vivo pharmacol-

ogy (mice, rats, cats, dogs, rabbits),103

Gallo-Torres, H. E., see Wills, R J., 433Ganglion, supranodose, gastric excitation,

stimulation ofvagal trunk (cats), 650Gardner, E. J., see Vaysse, P. J.-J., 534Garret, R, see Formby, B., 1106Gas chromatography, see Chromatography

Gastric emptyingL-364,718

in viva pharmacology (mice, rats, cats,dogs, rabbits), 103

role of endogenous cholecystokinin(dogs), 110

Geary, W. A., II, Wooten, G. F., Penn, J.B. and Lothman, E. W.: In vitro andin uwo distribution and binding ofphenytoin to rat brain, 704

Geiger, G., see Rimele, T. J., 771Geilman, R. L, Kallianos, J. A. and Mc-

Namara, J. 0.: Alpha-2 receptors me-diate an endogenous noradrenergicsuppression ofkindling development,891

Gepirone, alpha adrenoceptor activity (nab-bite, rats, guinea pigs, dogs), 771

Gerhardt, G. A., Pang, K. and Rose, G. M.:In vice electrochemical demonstra-

tion of the presynaptic actions ofphencycidine in rat caudate nucleus,714

Gesek, F. A., see Wolff, D. W., 472Ghai, G., see Williams, M., 415Giachetti, A., see Micheletti, R, 628Gibb, J. see Letter, A. A., 443Gilfillan, A. M. and Rooney, S. A.: Func-

tional evidence for adenosine A2 re-ceptor regulation of phosphatidyl-choline secretion in cultured type Hpneumocytes, 907

Gillespie, M. N., Kojima, S., Owasoyo, J. 0.,Tai, H. H. and Jay, M.: Hypoxia pro-yokes leukotriene-dependent neutro-

phil sequestration in perfused rabbithearts, 812

Gillespie, M. N., Moore, C. G., Wright, C.E. and O’Connor, W. N.: Salutaryeffects of prostaglandin E1 in per-fused rat lungs injuredwith hydrogenperoxide, 1

Gus, C. N., see Cherry, P. D., 516Ginsburg, R., see Rosenbaum, J. S., 354Glucagon, calcium, chronotropic action

(rats), 833a-Glucohydrolases, inhibition of intestinal

disaccharidases, suppression, bloodglucose (rats), 915

Glucose, central hyperglycemic action,mechanism, histamine (mice), 582

Glucucorticoid antagonist, RU 486, phar-macokinetic properties (humans),401

Goldberg, L. I., see Woolverton, W. L, 213Goldcompounds, regulation ofheme metab-

1987 Index 1133

olism, monooxygenases, liver andkidney (rats), 540

Goldstein, D. S., see Eisenhofer, G., 547Goods!, J. A., Eiaeman, J. L and Alvares,

A. P.: Regulation of heme metabo-lism and monooxygenases in liverand kidney Influence of therapeuti-cally used gold compounds, 540

Goodman, C., see Wolfe, J., 196Goodwin, R. M., see Spearman, M. E., 695Gordon, R, see Van Inwegen, R. G., 117Goto, K., Kimura, S. and SaitO, A.: Inhibi-

tory effect of calcitonin gene-related

peptide on excitation and contractionof smooth muscles of the rat yes def-erens, 635

Gould, R J., see Letti, V. J., 103Gould, H. J., see Pendleton, R. G., 110Grimes, D., see Rimele, T. J., 771Gross, G. J., see Wynsen, J. C., 846Guanylate cyclase, cyclic GMP formation,

phorbol ester-induced inhibition,

muscarinic receptors (mice), 3665’-Guanylyliznidodiphosphate, left atrium,

adaptive supensensitivity, character-iatic8 (guinea pigs), 453

Guengerich, F. P., see Knodell, R. G., 1112Guerret, M., see Chelly, J. E., 899GUild, S. and Reisine, T.: Molecular mach-

anisms ofcorticotropin-releasing fac-ton stimulation of calcium mobiliza-tion and adrenocorticotropin releasefrom anterior pituitary tumor cells,

125Guillon, G., see Cony, R� N., 258

HA1077, mechanism of action, antivaso-spasm (rabbits, dogs, guinea pigs),1033

Haemophilus influenzae, dual effects, betaadrenoceptors, trachea (guinea pigs),

994Hall, J.,see Kao, J., 482Hall, S. D., see Knodell, R. G., 1112Halopenidol, effect of methamphetamine,

neurotensin concentrations, brain re-gions (rats), 443

Halothane, stimulus properties, pentobar-bital-like (mice), 507

Hanson, G. H., see Letter, A. A., 443

Hanson, H. M., see Lotti, V. J., 103Hardy, K. J., see Ching, M. S., 1006Hank, S. I., Schmidley, J. W., lacofano, L

A., Blue, P., Arena, P. K. and Sayre,L M.: On the mechanisms underly-ing 1-methyl-4-phenyl-1,2,3,6-tetra-hydropynidine neurotoxicity The ef-feet of perinigral infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine, its metabolite and their an-

alogs in the rat, 669Harrington, J. W., see Harrison, N. L., 346

Harris, L T., see McCall, R B., 736Harrison, N. L, Majewska, M. D., Harning-

ton, J. W. and Barker, J. L.: Struc-ture-activity relationships for steroidinteraction with the ‘y-aminobutyricacid� receptor complex, 346

Hartley, C. J, see Chelly, J. E, 899Harvey, J. A., see Whisky, L, 223Hasegawa, J., see Kotake, H., 982Hatmi, M., del Maschio, A., Lefort, J., de

Gaetano, G., Vargaftig, B. B. andCerletti, C.: Effects of sulfinpyrazone

and its metabolite G25671 on platelet

activation and desensitization and onbronchoconstriction induced by theprostaglandin endoperoxide analog

U46619, 623Hawthorn, M. H., Taylor, D. A. and Flem-

ing, W. W.: Characteristics of adap-tive supersensitivity in the leftatrium of the guinea pig, 453

Hayashi, Y., see Adachi, H., 1072Hayes, J. S., see Imai, N., 20Hayes, J. S. and Bowling, N.: Role of the

alpha agonist activity of dobutaminein mediating cardiac output: Effectsof prolonged isoproterenol infusion,861

Heart, see also Myocardium

congestive failureblood flow response, piroximone vs. do-

butamine (dogs), 956hemodynamic effects, isomazole (dogs),

20contractility, HA1077, pharmacokinetic8

(rabbits, dogs, guinea pigs), 1033hypoxic, neutrophil sequestration (nab-

bits), 812intra-artenial injection of met-enkepha-

in, decreased vascular resistance(rabbits), 314

membrane binding, Bay K 8644 (rabbits),140

pheochromocytoma, effects, adrenergicreceptor antagonists (rats), 354

REV 5901, biochemical and pharmacolog-ical profile (guinea pigs), 117

sodium channel blockade, apnindine, yen-tnicular muscles (guinea pigs), 1065

Heart ratebehavioral effects and, adenosine analogs

(monkeys), 76conduction in cardiac Purkinje fibers, li-

docaine, interval-dependent effects(dogs), 275

effects of BM 123A, adenylate cyclase,mu8carinic receptors (rabbits), 804

glucagon and calcium, chronotropic ac-tion (rats), 833

Heaslip, R. J., see Rimele, T. J., 771Heme, metabolism, regulation, gold com-

pounds (rats), 540Hemodynamics

captopril, acute regional vascular effects,myocardial infarction (rats), 13

coronary and systemic, effects, verapamiland nitroglycerin (dogs), 1072

systemic and regional effects, isomazole,congestive heart failure (dogs), 20

Hemoglobin, nitrite conversion to nitric ox-ide, stabilization, 307

Henry, D. E., see Rimele, T. J., 771Heppner, B., see Petein, M., 956Heyman, J. S., see Porreca, F., 393Hidaka, H., see Asano, T., 1033Hinson, J. A., see Roberta, D. W., 527Hippocampua, changes in synaptic trans-

mission, AF64A intraventricular in-

fusion, 181Hirasawa, N., Ohuchi, K., Watanabe, M.

andTsurufuji, S.: Role of endogenoushistamine in postanaphylactic phaseof allergic inflammation in rats, 967

Hirooka, H., see Tsuji, A., 594Histamine

central hyperglycemic action, mechanism(mice), 582

cyclic GMP formation, phonbol ester-in-

duced inhibition, muscaninic recep-

tons (mice), 366endogenous, postanaphylactic phase, al-

lengic inflammation (rats), 967

HL 725, prostacyclin and, prevention of

thrombosis (rabbits), 855Hoffman, B. B., see Prokocimer, P. G., 870

Hoffman, B. B., see Rosenbaum, J. S., 354Holaday, J. W., see Chernow, B., 833

Holgate, S. T., see Richards, R., 1028Hood, W. B., Jr., see Imai, N., 20Hori, R., Maegawa, H., Okano, T., Takano,

M. and Inui, K.-!.: Effect of sulihy-dryl reagents on tetraethylammon-ium transport in rat renal brush ben-den membranes, 1010

Houston, D. A., Burnstock, G. and Van-houtte, P. M.: Different P2-purinergicreceptor subtypes on endotheliumand smooth muscle in canine bloodvessels, 501

Hubbard, J. see Srinivas, N. R, 300

Huffman, W., see Kinter, L. B., 797Hugman, L. E., see Wince, L C., 838Huidobro-Toro, J., see Llona, I., 608Hydralazine, pheochromocytoma, effects on

heart, adrenengic receptor antago-iiists (rats), 354

Hydrogen peroxide, inducedlung injury, sal-utary effects, prostaglandin E1 (rats),1

5-Hydroxylkynurenamine, interaction with1-kynurenine and kynurainine, mul-tiple serotonin receptors, smoothmuscle (rats, guinea pigs), 465

5-Hydroxytryptamine, see SerotoninHynes, M. D., see Zimmerman, D. M., 374Hynes, M. R. and Duckles, S. P.: Effect of

increasing age on the endothelium-mediated relaxation of rat blood yes-sels in vitro

Hyperglycemia, mechanam, histamine(mice), 582

Hypertensioncardiovascular effects, inhibitor, dopa-

mine 13-hydroxylase (rats), 554

mantenance of, sympathetic nervous sys-tam, pheochnomocytoma (rats), 870

Hypoxiaenhanced enythropoietin production, cal-

cium entry blockers (rats), 428neutrophil sequestration, leukotrienes

(rabbits), 812Hysing, E. S., see Chelly, J. E., 899

lacofano, L. A., see Hank, S. I., 669

Ibopamine, alpha adrenoceptor activity,comparison, pulmonary vasocon-striction (dogs), 6

Ibotenic acid, cortical noradrenaline release,effects of idazoxan, presynaptic a!-pha-2 adrenoceptors (rats), 642

IC! 118,551, beta-2 adrenoceptor, relaxation,isolated human saphenous vein(dogs), 294

Idazoxanalpha-i adrenoceptor heterogeneity, brain

(rats), 1079, 1092cortical noradrenaline release, role, pro-

synaptic a4,ha-2 adrenoceptors(rats), 642

Ikegaki, I., see Asano, T., 1033Ikezono, K., Zerkowski, H.-R., Beckeningh,

J. J., Michel, M. C. and Brodde, 0.-

E.: Beta-2 adrenoceptor-mediated re-

1134 Index

laxation ofthe isolated human saphe-nous vein, 294

Ileum, suppression, muscaninic M2 stimula-tion, histamine H1 receptors (guineapigs),587

Imai, N., Liang, C.-S., Stone, C. K., Hayes,J. S. and Hood, W. B., Jr.: Systemicand regional hemodynamic effects ofisomazole in awake dogs with conges-tive heart failure, 20

Imidazolines, alpha-i adrenergic coupling,full and partial agonists, aorta (nab-bits), 458

Indolalkylamines, AF64A intraventricular

infusion, changes, synaptic tranamis-sion, 181

Inhalants, stimulus properties (mice), 507

Inhalation, absorption and disposition Id-netics, cromolyn sodium (humans),1028

Inositol phosphate, stimulation, serotoninreceptor, WRK1 cells, 258

Inositol phospholipid hydrolysis, acute andchronic lithium treatments, cerebralcortex (rats), 1023

Insulin, low-dose cyclosporine, prophylaxis,nonobese diabetic mice, 1106

Intestinesinhibition of disaccharidases, blood glu-

cose, a-glucohydrolase inhibitor(rats), 915

small, transport ofcefixime, brush-bordermembrane vesicles (rats), 594

Inui, K.-!., see Hori, R., 1010�-Iodo-[’�IJ.-4-hydroxyphenyl-ethyl-amino-

methyl-tetralo ne, alpha-i adreno-

ceptor binding, aortas (dogs), 875Isapirone, alpha adrenoceptor activity (rab-

bits, rats, guinea pigs, dogs), 771Ishii, K. and Kato, R.: Suppression by mus-

carinic M2 stimulation of the con-tractile mechanism via histamine H1receptors in the longitudinal muscleof guinea pig ileum, 587

Isoamyl nitrite, stimulus properties, pento-barbital-like (mice), 507

Isoflurane, hemodynamic properties, dispo-sition, nicardipine (dogs), 899

Isomazole, hemodynamic effects, congestiveheart failure (dogs), 20

Isoproterenol

effect of dietary lipids, inotropic re-sponses, atrium (rats), 838

effects of clenbuterol, central beta-i andbeta-2 adrenergic receptors (rats),187

effects ofprolonged infusion, dobutamine,cardiac output (rats), 861

left atrium, adaptive supersensitivity,characteristics (guinea pigs), 453

Itoh, T., see Kimoto, Y., 1017Itoh, Y., see Nishibori, M., 582Izb#{233}ki,F., see Kov#{233}cs,G. L., 569

Jani8, R. A., see Sarmiento, J. G., 140Jay, M., see Gillespie, M. N., 812Johanson, C.-E., see Evans, S. M., 817Jolly, S., see Van Inwegen, R. G., 117Jones, A. W., see Jones, S. B., 875Jones, A. W., see Smith, J. M., 882

Jones, S. B., see Smith, J. M., 882Jones, S. B., Smith, J. M., Jones, A. W. and

Bylund, D. B.: Alpha-i adrenergic re-cepton binding in aortas from rat anddog Comparison of [3H]prazosin and

aminomethyl-tetralo ne, 875Jordan, S., see Bees, D. C., 507

Josepovitz, C., see Pastoniza-Munoz, E., 166Jost, K., see Kov#{227}cs,G. L., 569

Kaliyas, P. W., see Latimer, L. G., 328

Kalivas, P. W. and Duffy, P.: Sensitizationto repeated morphine injection in therat: Possible involvement of AlO do-pamine neurons, 204

Kallianos, J. A., see Gellman, R L, 891Kaloyanides, G. J., see Pastoniza-Munoz, E.,

166

Kamien, J. B., see Woolverton, W. L., 213Kao, J. and Hall, J.: Skin absorption and

cutaneous first pass metabolism oftopical steroids: in Vitro studies withmouse skin in organ culture, 482

Kato, R., see Ishii, K., 587Katnitzky, A. R., see Maren, T. H., 56Kawai, S., Nieman, L. K., Brandon, D. D.,

Udelsman, R, Loriaux, D. L. andChrousos, G. P.: Pharmacokineticproperties of the antiglucocorticoidand antiprogesterone steroid RU 486in man, 401

Keiser, H. R, see Eisenhofer, G., 547

Kendall, D. A. and Nahorski, S. R: Acuteand chronic lithium treatments influ-ence agonist and depolarization-stimulated inositol phospholipid hy-drolysis in rat cerebral cortex, 1023

Ketanserin, central sympathoinhibitory ac-tion, characterization (cats), 736

Keung, A. C., see Wick, P. F., 458Khandwala, A., see Van Inwegen, R G., 117Kidney

alpha adrenoceptors, in vivo assessment(rats), 472

brush border membranes, tetraethylam-monium transport, sulfhydryl re-agents (rats), 1010

drug toxicity, acetaminophen, obesity(rats), 921

interactions of diuretics, peripheral-typebenzodiazepine receptor (rats), 950

netilmicin, streptozotocin-induced diabe-tea mellitus (rats),166

propranolol metabolism in smokers,clearance of metabolites (humans),928

proximal and distal tubular effects, dose

dependence, furosemide (rats), 987regulation of heme metabolism, gold corn-

pounds (rats), 540renin release from cortical slices, calcium

channel agonists (rats), 1000Kim, M. B., see Wang, Y., 321Kimoto, Y., Nozaki, M. and Itoh, T.: Actions

of the alpha-i adrenoceptor blockerbunazosin on the norepinephrine-in-duced contraction of smooth musclesin the rabbit proximal urethra, 1017

Kimuna, S., see Goto, K., 635Kindling, noradrenergic suppression of de-

velopment, alpha-2 receptors (rats),891

Kinten, L. B., Churchill, S., Stamen, F. L.,Moore, M. and Huffman, W.: Vase-

pres8in antagonism in the squirrelmonkey (Saimiri sciureus), 797

Knisely, J. S., see Rees, D. C., 507Knodell, R. G., Hall, S. D., Wilkinson, G.

R. and Guengerich, F. P.: Hepatic

Vol. 241

metabolism of tolbutamide: Charac-terization of the form of cytochrome

P.450 involved in methyl hydroxyl-ation and relationship to in vivo dis-

position, 1112Koch, W. J., see Williams, J. S., 379Kodama, I., Toyama, J. and Yamada, K.:

Competitive inhibition of cardiac so-chum channels by aprindine and li-docaine studiedusinga maximum up-stroke velocity of action potential inguinea pig ventricular muscles, 1065

Kojima, S., see Gillespie, M. N., 812Kornulainen, H. and Bondy, S. C.: Modula-

tion of levels of free calcium within

synaptosomes by organochlorine in-secticides, 575

Kopia, G. A., Valocik, R. E., Torphy, T. J.,Cieslinksi, L. B., Sarau, H. M., Foley,J. J. and Wasserman, M. A.: Inhibi-tion of leukotriene D4-induced coro-nary vasoconstriction by leukotrieneantagonists in the anesthetized dog,174

Kopin, I. J., see Elsenhofer, G., 547Kotake, H., Matsuoka, S., Ogino, K., Tak-

ami, T., Hasegawa, J. and Mashiba,H.: Electrophysiological study of ci-benzoline in voltage-clamped rabbitsinoatrial node preparations, 982

Kov#{226}cs,G. L., Sarnyai, Z., IZb#{233}ki,F., Szab#{243},

G., Telegdy, G., Barth, T., Jost, K.and Brtnik, F.: Effects of oxytocin-related peptides on acute morphinetolerance: Opposite actions by oxy-tocin and its receptor antagonists,569

Kov#{227}cs,G. L, see de Wied, D., 268

Kreider, M. S., see Wolfe, J., 196

Kruse, L I., see Ohistein, E. H., 554

Kruszyna, H., see Kruszyna, R., 307Kruszyna, It, Kruszyna, H., Smith, R P.,

Thron, C. D. and Wilcox, D. E.: Ni-trite conversion to nitric oxide in redcells and its stabilization as a nitro-

sylated valency hybrid of hernoglo-bin, 307

Ku, D. D. and Ann, H. S.: Magnesium defi-ciency produces endothelium-de-pendent vasorelaxation in caninecoronary arteries, 961

Kupfer, A., see Fritz, S., 615Kurahashi, K., see Tsubornura, T., 650

Kurtzman, N. A., see Sabatini, S., 448Kynuramine, interaction with 5-hydroxy-

kynurenamine and 1-kynurenine,

multiple serotonin receptors, smoothmuscle (rats, guinea pigs), 465

L-364,718in vice pharmacology (mice, rats, cats,

dogs, rabbits), 103role of endogenous cholecystokinin,

biliary/pancreatic/gastric function

(dogs), 110Labetalol, antifibnillatory efficacy, beta ad-

renergic receptor blockade, methyl-scopolamine (dogs), 741

Lai, W. S. and El-Fakahany, E. E.: Phorbolester-induced inhibition of cyclicGMP formation mediated by musca-rinic receptors in murine neuroblas-toma cells, 366

Lamellar bodies, interactions of beta adre-

1987 Index 1135

nengic antagonists, alveolar type IIpneumocytes, 728

Langer, S. Z., see Scatton, B., 251Langerhans cells, low-dose cyclosporine,

prophylaxis, nonobese diabetic mice,1106

Latimer, L G., Duffy, P. and Kalivas, P.W.: Mu opioid receptor involvementin enkephalin activation of dopamineneurons in the ventral tegmentalarea, 328

Laursen, S. E., see Belknap, J. K., 477Leander, J. D., see Zimmerman, D. M., 374LeDuc, L E., see Zipser, R D., 218Lee, D. K. H., see Rimele, T. J., 771Lee, M. A., see Witkin, J. M., 34Lefort, J., see Hatmi, M., 623Leslie, F. M., see Boyajian, C. L., 1079,1092Letter, A. A., Merchant, K., Gibb, J. W. and

Hanson, G. it: Effect of methamphe-tamine on neurotensin ooncentra-tions in rat brain regions, 443

Leukotniene B4, neutrophil sequestration,hypoxic hearts (rabbits), 812

Leukotriene C4, salutary effects of prosta-glandin E1, hydrogen peroxide-in-duced lung injury (rats), 1

Leukotniene D4antigen and calcium ionophore-induced

release, comparison, lung (guinea

pigs), 786induced coronary vasoconstriction, inhi-

bition, leukotniene antagonists(dogs), 174

REV 5901, biochemical and pharmacolog-ical profile (guinea pigs), 117

Leukotrienes

biosynthesis, coronary arteries (dogs, hu-mans), 763

chemotactic peptide stimulation, healthyand inflamed colons (rabbits), 218

Levine, A. S., see Sharp, B. M., 438Levorphanol, induced antinociception, se-

lective breeding, hot-plate assay(mice), 477

Levy, G., see Ramzan, I. M., 236Lewis, H. A., see Richards, H., 1028L’Heureux, R, see Dennis, T., 642Liang, C.-S., see Imal, N., 20Lidocaine

antiarrhythmic drugs, use-dependent ef-fects, cardiac Purkinje fibers (dogs),

282cardiac sodium channels, block by aprin-

dine, ventricular muscles (guinea

pigs), 1065

enhanced a1-acid glycoprotein concentra-tion, protein binding, antiarrhythmic

effect (dogs), 289interval-dependent effects, conduction,

cardiac Purkinje fibers (dogs), 275Ligands

alpha-i adrenoceptor binding, aortas

(dogs), 875analgesic activity, mu receptor involve-

ment, �1-funaltrexamine (mice), 374Lindner, W., see Fritz, S., 615Lipids, unsaturated fat diet, inotropic re-

spouses, atrium (rats), 838Liposomes, calcium mobilization, protein

kinase inhibitor, anterior pituitary

tumor cells,125Lipoxygenase

leukotriene biosynthesis, coronary arter-ies (dogs, humans), 763

neutrophil sequestration, hypoxic hearts(rabbits), 812

Lisuride, discriminative stimulus proper-ties, dopamine D2 receptors (rats),147

Lithium, inositol phospholipid hydrolysis,cerebral cortex (rats), 1023

Liu, P. S., see Rhinehart, B. L., 915Liver

drug toxicity, acetaminophen, obesity

(rats), 921experimental disease, neurotoxicity, the-

ophylline (rats), 236metabolism of tolbutamide, methyl hy-

droxylation, 1112regulation of heme metabolism, gold corn-

pounds (rats), 540unbound prazosin elimination, a1-acid

glycoprotein (rats), 934Llona, I., Vavrek, R., Stewart, J. and Hui-

dobro-Toro, J. P.: Identification ofpro- and postsynaptic bradykinin re-ceptor sites in the vas deferens: Evi-dance for different structural prereq-

uiaites,608Uoyd, K. G., see Scatton, B., 251lloyd, K. G., Zivkovic, B., Sanger, D., Dc-

poortere, H. and Bartholini, G.: Fen-gabine, a novel antidepressant GA-BAergic agent. I. Activity in modelsfor antidepressant drugs and psycho-pharmacological proffle, 245

Lorenzo, B., see Cook, C. E., 779

Loriaux, D. L., see Kawai, S., 401Lothman, E. W., see Geary, W. A., II, 704Lotti, V. J., Pendleton, R. G., Gould, R. J.,

Hanson, H. M., Chang, R S. L andClineschmidt, B. V.: In vivo phar-macology of L-364,718, a new potentnonpeptide peripheral cholecystoki-nin antagonist, 103

Loughlin, S. E., see Boyajian, C. L., 1079Lucchesi, B. R., see Lynch, J. J., 741Lukeman, D. S. and Fanestil, D. D.: Inter-

actions of diuretics with the periph-eral-type benzodiazepine receptor inrat kidney, 950

Lungacetylcholine-induced vasodilatation,

role, endotheium-derived relaxingfactor (rabbits), 516

adenocarcinorna, disposition, LY256787and free 4-desacetylvinblastine(mice), 695

hydrogen peroxide-induced injury, salu-

tary effects, prostaglandin E1 (rats),1

peptidoleukotriene release, antigen andcalcium ionophore-induced (guineapigs), 786

LY 53857, ketansenin, central sympathoin-hibitory action, characterization

(cats), 736LY256787, free 4-desacetylvinblastine and,

disposition (mice), 695Lynch, J. J., Nelson, S. D., MacEwen, S. A.,

Dniscoll, E. M. and Lucchesi, B. R:Antifibnillatory efficacy of concomi-ts.nt beta adrenengic receptor block-ade with dilevalol, the R,R-isomer oflabetalol, and muscarinic receptor

blockade with methylscopolamine,741

MacEwen, S. A., see Lynch, J. J., 741

Macrophages, pulmonary, oxygen radicals,beta adrenoceptors (guinea pigs), 994

Maegawa, H., see Hori, R., 1010Magnesium, deficiency, vasorelaxation, con-

onary arteries (dogs), 961

Majewska, M. D., see Harrison, N. L., 346

Malcolm, D., see Chernow, B., 833Malveaux, E., see Faraj, B. A., 42Maren, T. H., Bar-Ilan, A., Caster, K. C.

and Katritzky, A. R.: Ocular phar-macology of methazolamide analogs:Distribution in the eye and effects onpressure after topical application, 56

Mark, M. R.: Amino acid uptake in dener-vated rat parotid glanth I. Prepara-tion andevaluation ofa lobule systemfor in vitro studies, 655

Mark, M. R.: Amino acid uptake in the ratparotid gland II. Effects of surgicalsympathectorny and parasympathec-

tomy, 663Marone, G., see Chiariello, M., 560Martin, B. see Beardsley, P. M., 521Martin, J. R and Takernori, A. E.: Modifi-

cation of the development of acuteopiate tolerance by increased dopa-mine receptor sensitivity, 48

Mashiba, H., see Kotake, H., 982Matsumura, Y., Unu, T., Shinyama, H.,

Saskaki, Y. and Monimoto, S.: Inhibi-tory effects of calcium channel ago-fists on renin release from rat kidneycortical slices, 1000

Matsuoka, S., see Kotake, H., 982Maze, M., see Prokocimer, P. G., 870Mazindol, amphetamine-like effects, ano-

rectics (pigeons), 817McAllen, K. M., see Sharp, B. M., 438McCall, R B. and Harris, L. T.: Character-

ization of the central sympathoinhi-bitory action of ketanserin, 736

McGonigle, a. J. S., Brookins, J., Pegram,B. L and Fisher, J. W.: EnhanCederythropoietin production by calciumentry blockers in rats exposed to hy-

poxia, 428McNamara, J. 0., see Gellman, R L, 891

McNamara, J. 0., see Platt, K., 751MDL 19,205, compared to dobutamine,

blood flow response, congestive heartfailure (dogs), 956

MDL 25,637, suppression of blood glucose,inhibition, intestinal disacchanidases(rats), 915

MDMA, see Methylenedioxymethylamphe.t.amine

Mefenorex, amphetamine-like effects, ano-rectics (pigeons), 817

Mephenytoin, phenytoin hydroxylation,stereochemistry, phenotypes (hu-mans), 615

S-Mephenytoin, hepatic metabolism, tol-butamide, methyl hydroxylation,1112

Mepyramine, central hyperglycemic action,mechanism, histamine (mice), 582

Mercer, G. D., see Vestal, R. E., 488

Merchant, K., see Letter, A. A., 443Menin, R. G., see Chelly, J. E., 899Mesentery, endogenous norepinephnine re-

lease, periarterial nerve stimulation(rats), 826

Metaphit, interactions with phencycidine,sigma agonist actions, cerebellum(rats), 321

1136 Index

Met-enkephalin, see EnkephalinMethadone, analgesic activity, mu opioid

receptor involvement, �9-funaltrex-amine (mice), 374

Methamphetamine, effect, neurotensin con-centrations, brain (rats), 443

Methazolamide analogs, ocular pharmacol-ogy, distribution in eye, effects onpressure (rabbits), 56

Methoxamine, noradrenergic denervation,alpha-i adrenoceptors, muscle con-traction (chicks), 939

a,fl-Methylene, P2-purinergic receptor sub-types, endotheium and smooth mus-dc, blood vessels (dogs), 501

Methylenedioxymethylamphetamine, neu-rotoxiceffects, neurons in brain (rats,guinea pigs),338

Methytmercury, spontaneous release of ac-etylcholine, sodium activation, cal-ciurn entry (rats), 131

Methylphenidate, stereoselective disposi-tion, children, attention-deficit dis-order, 300

threo-Methylphenidate, enantiomers, phar-macology of (rats), 152

i-Methyl-4-phenyl-1,2,3,6-tetrahydropyni-dine, neurotoxicity, mechanisms(rats), 669

Methylscopolaxnine, rnuscariic receptor

blockade, antifibrillatory efficacy,beta adrenergic receptors (dogs), 741

Metopnine, central hyperglycemic action,

mechanism, histamine (mice), 582

Metyrapone, central hyperglycemic action,

mechanism, histamine (mice), 582Mexiletine, antiarrhythmic drugs, use-de-

pendent effects, cardiac PUrkinje fi-bars (dogs), 282

Michel, M. C., see Ikezono, K., 294Micheletti, H., Montagna, E. and Giachetti,

A.: AF-DX 116, a cardioselectivemuacarmnic antagonist, 628

Midha, K. K., see Sninivas, N. It, 300Mihaly, G. W., see Ching, M. S., 1006

Miller, N., see Formby, B., 1106Mm, B. H., see Willis, R. J., 433Mir, G. N., see DiJoseph, J. F., 97Mmcx, free calcium modulation, synapto-

sornes, organochlorine insecticides

(rats), 575Mittag, T. W., Tormay, A. and Podos, S.

M.: Vasoactive intestinal peptide andintraocular pressure: Adenylate cy-cl.�ae activation and binding sites for

vasoactive intestinal peptide in mem-branes ofocular diliaryprocesses, 230

Mocchetti, I., Naranjo, J. R. and Costa, E.:Regulation of stniatal enkephalinturnover in rats receiving antag-

onists of specific dopamine receptorsubtypes, 1120

Molenaar, P., Canale, E. and Summers, R.J.: Autoradiographic localization ofbeta-i and beta-2 adrenoceptors inguinea pig atrium and regions of theconducting system, 1048

Molenaar, P. and Summers, H. J.: Charac-terization of beta-i and beta-2 adren-oceptors in guinea pig atrium: Func-tional and receptor binding studies,1041

Monoclonal antibodies, LY256787 and free4-desacetylvinblastine, disposition(mice), 695

Monooxygenases, regulation of heme me-tabolism, gold compounds, liver andkidney (rats), 540

Montagna, E., see Micheletti, R., 628Moore, C. G., see Gillespie, M. N., 1Moore, M., see Kinter, L B., 797Morgan, D. J., see Ching, M. S., 1006Monimoto, S., see Matsumura, Y., 1000

Morley, J. E., see Sharp, B. M., 438Morphine

amphetamine-like effects, anorectics (pi-

geons), 817analgesic activity, mu opioid receptor in-

volvement, fi-funaltrexamine (mice),374

levorphanol-induced antinociception, se-

lective breeding, hot-plate assay(mice), 477

sensitization to repeated injection, AiOdopamine neurons (rats), 204

tolerance, effects, oxytocin-related pep-tides (mice), 569

Mosberg, H. I., see Porreca, F., 393Muacevic, G., see Casals-Stenzel, J., 974Murphy, S. D., see Ba1dUini, W., 421Muscimol, anticonvulsant action, alpha-2

adrenoceptors (rats), 751Muscle, suppression of rnuscaninic M2 stim-

ulation, histamine H1 receptors,ileum (guinea pigs), 587

Muscle, smoothalpha-i adrenergic coupling events, full

and partial agonists, aorta (rabbits),458

aortic, calcium channel blockers, cornea-tion (rabbits), 91

coronary, role of endotheium, dihydro-pyridine calcium channel modulators(porcine), 379

endotheium and, P2-puninergic receptorsubtypes, blood vessels (dogs), 501

expansor secundariorum, noradrenergicdenervation, alpha-i adrenoceptors(chicks), 939

interaction of kynurenine derivatives,multiple serotonin receptors (rats,

guinea pigs), 465norepinephrine-induced contraction,

bunazosin, proximal uretha (rabbits),1017

vascular

muscaniic receptor subtypes, saphe-nous vein (dogs), 64

postjunctional alpha adrenoceptors,limbs (humans), 361

variation in sensitivity, norepinephnine(rabbits), 239

vas deferens, inhibitory effect, calcitoningene-related peptide (rats), 635

Myocardium, see also Heart

beta adrenoceptors, autoradiographic lo-calization, atrium (guinea pigs), 1048

effects of BM 123A, muscarinic receptors,adenylate cyclase (rabbits), 804

hypoxic, neutrophil sequestration (nab-bits), 812

infarction

antifibnillatory efficacy, dilevalol(dogs), 741

captopnil, acute regional vascular ef-fects (rats), 13

ischemia, phospholipase activation, quin-acme (rats), 560

MyxicoLa, giant axons, dendrotoxin effects,potassium and sodium channels, 793

Vol. 241

Nahorski, S. R, see Kendall, D. A., 1023Nakamura, M., see Adachi, H., 1072Naphthoxylactic acid, renal clearance, pro-

pranolol metabolism in smokers (hu-mans), 928

Naranjo, J. R., see Mocchetti, I., 1120Nattel, S.: Interval-dependent effects of li-

docaine on conduction in canine car-

disc PUrkinje fibers: Experimentalobservations and theoretical analy-

sis, 275Nattel, S.: Relationship between use-dc-

pendent effects of antiarrhythmic

drugs on conduction and � in ca-nine cardiac PUrkinje fibers, 282

Nelson, S. D., see Lynch, J. J., 741Nerves

adrenergic, muscarinic receptor subtypes,saphenous vein (dogs), 64

periartenial, endogenous norepinephrinerelease, mesenteric vasculature

(rats), 826Netilmicin, renal handling, streptozotocin-

induced diabetes mellitus (rats), 166

Neuroblastoma cells, muscaninic receptors,cyclic GMP formation, phorbol ester-induced (mice), 366

Neuromuscular junction, aminoglycoside-induced blockade, potentiation, pro-tons (frogs, rats), 686

NeuronsAlO dopamine, repeated morphine injec-

tion, sensitization (rats), 204-y-aminobutynic acid� receptor complex,

structure-activity relationships, ste-roid interaction (rats), 346

toxicity, methylenedioxymethylamphe-tamine (rats, guinea pigs), 338

Neurotensin, effect of methamphetamine,brain regions (rats), 443

Neurotoxicity1-methyl-4-phenyl-1,2,3,6-tetrahydropyr-

idine, mechanisms (rats), 669nonmuscarmnic, oxotremonine (rats), 34theophylline, experimental liver disease

(rats), 236tyramine, brain technetium-99m-diethy-

lenetriainine penta-acetic acid(dogs), 42

Neurotransmitters, presynaptic actions of

PCP, in vioc electrochemical dem-onstration, caudate nucleus (rats),714

Neutrophils

role of endogenous histamine, postana-phylactic phase, allergic inflam-

mation (rats), 967sequestration, hypoxic hearts (rabbits),

812Nevola, E., see Chianiello, M., 560Nicardipine, disposition, role of isoflurane,

hemodynamic properties (dogs), 899Nicorandil, differential effects on presser

responses, alpha adrenoceptor ago-nists (dogs), 846

Nicotine

inhibition, plasma prolactin response, re-

straint stress (rats), 438nonmuscarinic neurotoxicity, oxotremo-

rime (rats), 34Nieman, L K., see Kawai, S., 401Nifedipine

Bay K 8644, charactenisties of binding,cardiac membranes (rabbits), 140

differential effects on presser responses,

1987 Index 1137

alpha adrenoceptor agonists (dogs),846

Nijkamp, F. P., see Engels, F., 994Nishibori, M., Itoh, Y., OiShi, R. and Saeki,

K.: Mechanism of the central hyper-glycemic action of histamine in mice,582

Nishijima, H., see Adachi, H., 1072Nitrendipine, calcium channel blockers,

correlation, receptor binding andcontractility (rabbits), 91

Nitrites

conversion to nitric oxide, red cells, sta-bill.zation, 307

stimulus properties, inhalants (mice), 507Nitroglycerin

differential effects on presser responses,alpha adrenoceptor agonists (dogs),846

verapamil and, coronary and systemichemodynamics (dogs), 1072

Nolan, T. E., see Pendleton, R. G., 110Noordewier, B., see Belknap, J. K., 477Noradrenaline

fengabine, effects on cerebral transmis-sion (rats), 251

inositol phospholipid hydrolysis, lithiumtreatments, cerebral cortex (rats),1023

release, effects of idazoxan, presynapticalpha-2 adrenoceptors (rats), 642

Norepinephrine

AF64A intraventricular infusion,changes, synaptic transmission, 181

alpha-i adrenoceptorsactivity (rabbits, rats, guinea pigs,

dogs), 771anticonvulsant action, rnuscimol (rats),

751thoracic aorta, hypertension (rats), 882

amino acid uptakeparotid gland, lobule system (rats), 655parotid gland, surgical sympathectomy

(rats), 663central hyperglycemic action, mechanism,

histamine (mice), 582effect of dietary lipids, inotropic re-

spouses, atrium (rats), 838enantiomers of threo-methylphenidate,

pharmacology of (rats), 152endogenous, release from mesenteric vas-

culature, periartenial nerve stimula-tion (rats), 826

endogenous and exogenous, dihydroxy-phenylglycol, vas deferens (rats), 547

induced smooth muscle contraction, a!-pha-1 adrenoceptors, bunazosin (nab-

bits), 1017left atrium, adaptive supersensitivity,

characteristics (guinea pigs), 453postjunctional alpha adrenoceptors, dif-

ferential distribution, limbs (hu-mans), 361

suppression of kindling development, at-pha-2 receptors (rats), 891

variation in sensitivity, contraction, vas-cular smooth muscle (rabbits), 239

Nozaki, M., see Kimoto, Y., 1017

Obesity, drug toxicity, acetaminophen(rats), 921

O’Connor, W. N., see Gillespie, M. N., 1O’Donnell, J. M., see Ordway, G. A., 187O’Donnell, J. M.: Effects ofclenbuterol and

prenalterol on performance during

differential reinforcement of low re-sponse rate in the rat, 68

Ogino, K., see Kotake, H., 982Ohlstein, E. H., Kruse, L I., Ezekiel, M.,

Sherman, S. S., Erickson, R, Dc-Wolf, W. E., Jr. and Berkowitz, B.A.: Cardiovascular effects of a newpotent dopamine �-hydroxylase in-hibitor in spontaneously hypenten-sive rats, 554

Ohuchi, K., see Hirasawa, N., 967#{216}ie,S., Fiori, F. and Chang, J.: Decreased

elimination of unbound prazosin inthe presence of a1-acid glycoproteinin the rat in vivo, 934

Oishi, R, see Nishibori, M., 582Okamoto, T., see Tsubornura, T., 650Okano, T., see Hori, H., 1010Olfactory bulbectomy, fengabine, activity in

models, psychopharmacological pro-file (rats), 245

Olsen, R. W., see Yang, J. S.-J., 677Omnass, J. R., see Porreca, F., 393Oosting, R. S., see Engels, F., 994Opiates, acute tolerance, modification of de-

velopment, dopamine receptor sensi-tivity (mice), 48

Opioidsintra-arterial injection of met-enkepha-

lin, decreased vascular resistance(rabbits), 314

sigma agonist, metaphit and phencyci-dine, cerebellum (rats), 321

Ordway, G. A., O’Donnell, J. M. and Fraser,A.: Effects of clenbuterol on centralbeta-i and beta-2 adrenergic recep-

tore of the nat, 187Oriowo, M. A., Bevan, J. A. and Bevan, R.

D.: Variation in sensitivity of alphaadrenoceptor-mediated contractionofthe vascular smooth muscle of nab-bit elastic and muscular arteries isrelated to receptor affinity, 239

O’Rourke, S. T. and Vanhoutte, P. M.: Sub-types of muscaninic receptors on ad-renergic nerves and vascular smoothmuscle of the canine saphenous vein,

64Owasoyo, J. 0., see Gillespie, M. N., 812Oxazepam, stimulus properties, pentobar-

bital-like (mice), 507Oxotremorine

alkylating derivative BM 123A, effects onmyocardium (rabbits), 804

nonmuscarinic neurotoxicity (rats), 34Oxygen, radicals, beta adrenoceptor func-

tion, Haemophilus influenzae (guineapigs), 994

Oxytocineffects of related peptides, acute men-

phine tolerance (mice), 569vasopressin and, C-terminal fragments,

avoidance behavior (rats), 268

Palmer, M. H., see Wang, Y., 321Pancreas

L-364,718in vice pharmacology (mice, rats, cats,

dogs, rabbits), 103role of endogenous cholecystokinin

(dogs), 110Pang, K., see Gerhardt, G. A., 714Panzer-Knodle, S., see Papaioannou, S., 91Papaioannou, S., Panzer-Knodle, S. and

Yang, P.-C.: Calcium channel block-

ers: Correlation among receptorbinding, calcium uptake and contrac-tiity in vitro, 91

Parasympathectorny, parotid gland, aminoacid uptake (rats), 663

Parathyroid, hormone fragments, calciumtransport, bladder (toads), 448

Park, B. K., see Vestal, R E., 488Parkinson’s disease, neurotoxicity, 1-

methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine, mechanisms (rats), 669

Parmar, N. S., see Tariq, M., 602Parotid gland

amino acid uptakelobule system (rats), 655sympathectomy, parasympathectomy

(rats), 663Pastoniza-Munoz, E., Josepovitz, C., Ram-

sammy, L. and Kaloyanides, G. J.:Renal handling of netilmicin in therat with streptozotocin-induced dia-betes mellitus, 166

Patrick, K. S., Caldwell, R. W., Ferris, R.M. and Breese, G. R: Pharmacologyof the enantiomers of threo-rnethyl-phenidate, 152

Patterson, J. B., see Zipser, R. D., 218Payne, A. J.,see Rhinehart, B. L., 915PCP, see Phencyclidine[D-Pen2,D-Pen5J-Enkephalin, mu and delta

receptors, supraspinal and spinal an-algesic effects (mice), 393

Pegram, B. L, see McGomgle, R. J. S., 428Pendleton, R G., Bendesky, R J., Schaffer,

L., Nolan, T. E., Gould, R. J. andClineschmidt, B. V.: Roles of endog-enous cholecystokinin in biliary, pan-creatic and gastric function: Studieswith L-364,718, a specific cholecys-tokinin receptor antagonist, 110

Pendleton, R. G., see Lotti, V. J., 103Pentazocine, levorphanol-induced antinoci-

ception, selective breeding, hot-plateassay (mice), 477

Pentobarbitalenantiomers, pharmacokinetics, racemate

(humans, rabbits), 779

stimulus properties, inhalants (mice), 507Peptidoleukotrienes, release from lung

preparations, antigen and calcium io-nophore-induced (guinea pigs), 786

Perlin, J. B., see Geary, W. A., II, 704Perrone-Filardi, P., see Chiariello, M., 560Petein, M., Heppner, B., Bache, R. J., Cohn,

J. N. and Pierpont, G. L.:namic and regional blood flow re-aponse to piroximone (MDL,19205)in dogs with congestive heart failure:

A comparison with dobutamine, 956Peterson, C. M., see Formby, B., 1106

pH, aminoglycoside-induced neuromuscularblockade, potentiation, protons(frogs, rats), 686

Phencyclidineamphetamine-like effects, anorectics (pi-

geons), 817discriminative stimulus effects, separa-

tion of response rate (rats), 159interactions with metaphit, sigma agonist

actions, cerebellum (rats), 321presynaptic actions, in vivo electrochem-

ical demonstration, caudate nucleus(rats), 714

Phendirnetrazine, amphetamine-like ef-fects, anorectica (pigeons), 817

1138 Index

Phentermine, amphetamine-like effects, an-

orectics (pigeons), 817Phentolamine, aLpha-i adrenoceptor bind-

ing, aortas (dogs), 875Phenylephrine

alpha adrenoceptorsactivity (rabbits, rats, guinea pigs,

dogs), 771postjunctional, limb differential distri-

bution (humans), 361thoracic aorta, hypertension (rats), 882

alpha agonista, vasodilator inhibition(dogs), 846

N�-(L-Phenylisopropyl)adenosine, effects,acquisition, conditioned responses

(rabbits), 223Phenylpropanolamine, amphetamine-like

effects, anorectics (pigeons), 817Phenytoin

distribution and binding, in vitro and invivo, brain (rats), 704

hydrozylation, stereochemistry, pheno-types (humans), 615

Pheochromocytomaeffects ofadrenergic receptor antagonists,

heart (rats), 354maintenance of hypertension, sympa-

thetic nervous system (rats), 870Phorbol esters, induced inhibition, cyclic

GMP formation, muscaninic recep-

tore (mice), 366Phosphatidylcholine, secretion in type II

pneumocytes, adenosine A2 receptor

regulation (rats), 907Phosphodiesterase

congestive heart failure, hemodynamic ef-fect.s, isomazole (dogs), 20

inhibitor, prostacydlin and, prevention ofthrombosis (rabbits), 855

Phosphoinositidealpha-i adrenergic coupling, full and par-

tie�l agonists, aorta (rabbits), 458

muscaninic receptor-stimulated metabo-11am, developmental changes, brain(rats), 421

Phospholipase, ischemia-induced activa-don, infarct size reduction, quina-

crime (rats), 560L-PIA, see N’-(L-Phenylisopropyl)

adenosinePierpont, G. L, see Petein, M., 956Pillar, J., see Cheng, J. B., 786Piocarpine, nonmuscarinic neurotoxicity,

oxotremonine (rats), 34Pindolol, beta agonists and antagonists, in-

teraction, brain (rats),755Piomelli, D., Feinniark, S. J. and Cannon,

P. J.: Leukotniene biosynthesis by ca-nine and human coronary arteries,763

Piroximone, comparedto dobutamine, bloodflow response, congestive heart fail-ure (dogs), 956

Pituitary, anterior, blocked calcium mobili-zation, protein kinase inhibitor, 125

Placenta, low clearance, cimetidine (hu-mans), 1006

Platelet activating factor, antagonist of,WEB 2086, pharmacological actions(humans), 974

Platelets, activation, bronchoconstniction,

effects of sulfinpyrazone (humans),

623Patt, K., Butler, L S., Bonhaus, D. W. and

McNamara, J. 0.: Evidence implicat-

ing alpha-2 adrenergic receptors inthe anticonvulsant action of intra.nigral muscimol, 751

Pneumocyte8, phosphatidylcholine secre-

tion, adenosine A2 receptor regula-tion (rats), 907

Podos, S. M., see Mittag, T. W., 230

Polymethylenemethane thiosulfonates, hy-polipidemic effect, inhibitors, aceto-

acetyl coenzyme A thiolase (rats),1099

Pomfret, D. W., Schneck, K. W., Fludzinski,P. and Cohen, M. L: Interaction of5-hydroxykynurenamine, L-kynu-renine and kynuramine with multipleserotonin receptors in smooth mus-dc, 465

Porreca, F., Heyman, J. S., Mosberg, H. I.,Omnaas, J. R. and Vaught, J. L: Roleof mu and delta receptors in the su-praspinal and spinal analgesic effectsof ID-pen2, D-pen5jenkephalin in themouse, 393

Potassium

calcium channel blockers, receptor bind-ing and contractility, correlation(rabbits), 91

efflux, alpha-i adrenoceptors, hyperten-

sion (rats), 882Potassium channel, dendrotoxin blockade,

sodium inactivation, Myxicola giantaxons, 793

Potter, D. W., see Roberts, D. W., 527Prazosin

alpha adrenoceptorsactivity (rabbits, rats, guinea pigs,

dogs), 771binding, aortas (dogs), 875postjunctional, limb differential distni-

bution (humans), 361thoracic aorta, hypertension (rats), 882

ketansenin, central sympathoinhibitoryaction, characterization (cats), 736

maintenance of hypertension, sympa-thetic nervous system, pheochromo-cytoma (rats), 870

unbound, decreased elimination, a1-acidglycoprotein (rats), 934

Prenalterol, effects on performance, low re-sponse rate, differential reinforce-ment (rats), 68

PrOCainamide, antiarrhythmic drugs, use-

dependent effects, cardiac PUrkinjefibers (dogs), 282

Progesterone antagonist, RU 486, pharma-cokinetic properties (humans), 401

Proglumide, antiulcercytoprotective effects,gastric and duodenal (rats), 602

Prokocimer, P. G., Maze, M. and Hoffman,B. B.: Role of the sympathetic nerv-ous system in the maintenance ofhypertension in rats harboring phe-ochromocytoma, 870

Prolactin, stress response, inhibition, nic-otine (rats), 438

Promethazine, central hyperglycemic ac-tion, mechanism, histamine (mice),582

Propranololeffects of clenbuterol and prenalterol, low

response rate, differential reinforce-ment (rats), 68

selective induction of metabolism, smok-ing, renal clearance (humans), 928

Prostacyclin, combined with phosphodies-

Vol.241

terase inhibitor, prevention of throm-bosis (rabbits), 855

Prostaglandin E1, salutary effects, hydrogenperoxide-inducedlung injury (rats), 1

Prostaglandin E2 analog, tnimoprostil, phar-macokinetics, antisecretory activity(dogs), 433

Prostaglandinachemotactic peptide stimulation, healthy

and inflamed colons (rabbits), 218U46619-induced bronchoconstriction, ef-

fects of sulfinpyrazone, platelet acti-vation (humans), 623

Protein, adducts, acetaminophen, sensitiveassay (rabbits), 527

Protons, neuromuscular blockade, amino-glycoside-induced, potentiation

(frogs, rats), 686Psychoyos, S., see Williams, M., 415Pumford, N. R., see Roberts, D. W., 527Purkinje fibers

conduction in, lidocaine, interval-depend-ent effects (dogs), 275

electrophysiology of quinidine, compari-son, dihydroquinidine (dogs), 84

Quinacnine, inhibition, ischemia-inducedphospholipase activity, myocardium(rats), 560

Quinidineantiarrhythmic thugs, use-dependent ef-

facts, cardiac Purkinje fibers (dogs),282

electrophysiology, comparison, dihydro-quinidine (dogs), 84

Quinn, D., see Srinivas, N. It, 300

Racemate, pentobarbital enantiomers,pharmacokinetics (humans, rabbits),779

Radioligandsalpha-i adrenoceptors

binding, aortas (dogs), 875correlation with potassium effluix, hy-

pertension (rats), 882Ramsammy, L, see Pastoriza-Munoz, E.,

166Ramzan, I. M., Yasuhara, M. and Levy, G.:

Kinetics of drug action in diseaseatate8. XIX. Effect of experimental

liver disease on the neurotoxicity oftheophylline in rats, 236

Rannels, D. E., see Fabisiak, J. P., 722,728Rauwolacine

alpha-i adrenoceptorsheterogeneity, brain (rats), 1079, 1092postjunctional, limb differential distri-

bution (humans), 361Receptors

adenosineacquisition of conditioned responses, L-

PIA (rabbits),223triazoloquinazoline, biochemical char-

actenization, 415adenosine A2, phosphatidylcholine scene-

tion, type H pneumocytes (rats), 907affinity, variation in sensitivity, norepi-

nephrine (rabbits), 239alpha adrenergic, see Adrenoceptorsantagonists, acute morphine tolerance,

oxytocin-related peptides (mice), 569benzodiazepine, interactions of diuretics,

kidney (rats), 950beta adrenergic, see Adrenoceptors

1987 Index 1139

binding, calcium channel blockers, come-lation (rabbits), 91

bradykinin, structural prerequisites, vasdeferens (rats, mice, guinea pigs,hamsters), 608

dopamineacute opiate tolerance, modification of

development (mice), 48stniatal enkephalin turnover, regula-

tion, 1120dopamine D2

apomorphine, discriminative stimulus(monkeys), 213

lisuride, discriminative stimulus prop-erties (rats), 147

GABAA, st�UctU��tivity relationships,steroid interaction (rats), 346

histamine H1, suppression of muscaninicM2 stimulation, ileum (guinea pigs),587

mu and delta� supraspinal and spinal an-algesic effects, enkephalin (mice),393

mu opioid

enkephalin activation ofdopamine neu-rons, ventral tegmental area (rats),328

fi-funaltrexamine, analgesic activity ofligands (mice), 374

muscarinic

AF-DX 116 (guinea pigs), 628antifibnillatory efficacy, dilevalol

(dogs), 741cyclic GMP formation, neuroblastoma

cells (mice), 366effects of BM 123A, myocardium (rab-

bits), 804neurotoxicity, oxotremomine (rats), 34phosphoinositide metabolism, develop-

mental changes in brain (rats), 421subtypes on adrenergic nerves, saphe-

nous vein (dogs), 64muscarinic M2, histamine H1 receptors,

ileum (guinea pigs), 587opioid, modulation by cannabinoids,

brain (rats), 534P2-purinergic, endotheium and smooth

muscle, blood vessels (dogs), 501P1 puninoceptor, adenosine, surfactant se-

cretion (rats), 907serotonin

kynuremne derivatives, smooth muscle

(rats, guinea pigs), 465stimulation, inositol phosphate forms-

tion, 258Red blood cells, nitrite conversion to nitric

oxide, stabilization, 307Reel, J. K., see Zimmerman, D. M., 374Race, D. C., Knisely, J. S., Balster, R L,

Jordan, S. and Breen, T. J.: Pento-barbital-like discriminative stimulus

properties of halothane, 1,1,1-tricho-lorethane, isoamyl nitrite, flurothyl

and oxazepam in mice, 507Reflexes, baroreflex, isoflurane, nicardipine

disposition (dogs), 899

Reisine, T., see Guild, S., 125Rernn, release from kidney cortical slices,

calcium channel agonists (rats), 1000Renwick, A. G., see Richards, R, 1028Reserpine

dihydroxyphenylglycol and intnaneuronalmetabolism, norepinephrine, vas def-erens (rats), 547

left atrium, adaptive supersensitivity,characteristics (guinea pigs), 453

REV 5901, biochemical and pharmacologi-cal profile (guinea pigs), 117

Reye’s syndromebrain technetium-99m-diethylenetnia-

mine penta-acetic acid

tyramine neurotoxicity (dogs), 42Rhinehart, B. L., Robinson, K. M., Liu, P.

S., Payne, A. J., Wheatley, M. E. andWagner, S. R.: Inhibition of intes-tinal disaccharidases and suppres-

sion of blood glucose by a new a-

glucohydrolase inhibitor-MDL 25,637,915

Richards, R, Dickson, C. R, Renwick, A.

G., Lewis, R A. and Holgate, S. T.:Absorption and disposition kineticsofcromolyn sodium and the influenceof inhalation technique, 1028

Rifampicin, antiarrhythmic effect of lido-caine, enhanced a1-acid glycoprotein,protein binding (dogs), 289

Riinele, T. J., Henry, D. E., Lee, D. K. H.,

Geiger, G., Heaslip, H. J. and Grimes,D.: Tissue-dependent alpha adreno-receptor activity ofbuspirone andre-lated compounds, 771

Robbins, R K., see Wince, L. C., 838Roberts, D. W., Pumfond, N. It, Potter, D.

W., Benson, H. W. and Hinson, J. A.:A sensitive immunochemical assayfor acetaminophen-protein adducts,527

Robinson, K. see Rhinehart, B. L, 915Roden, D. M., see Thompson, K. A., 84Rolipram, effects, acquisition, conditioned

responses (rabbits), 223Rooney, S. A., see Gilfillan, A. M., 907

Roots, I., see Fritz, S., 615Ropchak, T. G., see Eisenhofen, G., 547Rose, G. M., see Gerhardt, G. A., 714Rosenbaum, J. S., Ginsburg, R, Billingham,

M. E. and Hoffman, B. B.: Effects ofadrenergic receptor antagonists oncardiac morphological and functionalalterations in rats harboring pheo-chromocytoma, 354

Rouot, B., see Cory, R. N., 258RU 486, pharmacokinetic properties (hu-

mans), 401Ruffolo, R. R., Jr., see Shebuski, R. J., 6

Sabatini, S., Yang, W.-C. and Kurtzman, N.A.: Effect of parathyroid hormonefragments on calcium transport intoad bladder, 448

Saeki, K., see Nishibori, M., 582Saito, A., see Goto, K., 635Salam, W. H. and Bloxham, D. P.: Hypoli-

pidemic effect of polymethylenerne-

thane thiosulfonates: Inhibitors ofacetoacetyl coenzyme A thiolase,

1099Salay, J. M., see Beardsley, P. M., 159Sangen, D., see Uoyd, K. G., 245Saphenous vein

isolated human, relaxation, beta-2 adre-nocepton, 294

muscarinic receptor subtypes, adrenergicnerves, vascular smooth muscle(dogs), 64

P2-puninengic receptor subtypes, endothe-lium, smooth muscle (dogs), 501

Sarau, H. M., see Kopia, G. A., 174

Sarmiento, J. G., Shrikhande, A. V., Janis,R A. and Triggle, D. J.: [3H]BAY K8644, a 1,4-dihydropyridine Ca�channel activator Characteristics ofbinding to high and low affinity sites

in cardiac membranes, 140Sarnyai, Z., see Kov#{225}cs,G. L, 569Sarper, R, see Faraj, B. A., 42Saskaki, Y., see Matsumura, Y., 1000Satoh, S.-!., see Asano, T., 1033Sayre, L. M., see Hank, S. I., 669Scatton, B., Lloyd, K. G., Zivkovic, B., Den-

nis, T., Claustre, Y., Dedek, J., Ar-bills, S., Langer, S. Z. and Bartholini,G.: Fengabine, a novel antidepressantGABAergic agent. II. Effect on cere-bral noradrenergic, serotonergic andGABAergic transmission in the rat,251

Scatton, B., see Dennis, T., 642SCH 23390, dopamine receptor subtypes,

regulation, atniatal enkephalin turn-over, 1120

Schadt, J. C., see Wightman, J. M., 314Schaffer, L., see Pendleton, R G., 110Schauf, C. L: Dendrotoxin blocks potas-

sium channels and slows sodium in-activation in Myxicola giant axons,793

Schmidley, J. W., see Hank, S. I., 669Schmidt, F. see Faraj, B. A., 42Schneck, K. W., see Pomfret, D. W., 465Schuster, C. R, see Commins, D. L., 338Schwartz, A., see Williams, J. S., 379Scimeca, J: A., see Beardsley, P. M., 521Seiden, L S., see Commins, D. L., 338Seizures

kindling development, noradrenergicsuppression, a4,ha-2 receptors (rats),891

neurotoxicity, theophylline, experimentalliver disease (rats), 236

Seltzman, T. B., see Cook, C. E., 779Serotonin

AF64A intraventricular infusion,changes, synaptic transmission, 181

agonists, stimulation, inositol phosphateformation, 258

dopamine D2 receptors, lisuride, discrim-

inative stimulus properties (rats), 147fengabine, effects on cerebral transmis-

sion (rats), 251neurotoxicity, methylenedioxymethylani-

phetamine, brain (rats, guinea pigs),338

nonadrenergic denervation, alpha-iadrenoceptors, muscle contraction(chicks), 939

uptake sites, in vivo labeling, [3HJ-cy-anoimipramine (rats), 196

Sharp, B. M., Reyer, H. S., Levine, A. S.,Morley, J. E. and McAllen, K. M.:Attenuation of the plasma prolactin

response to restraint stress afteracute and chronic administration ofnicotine to rats, 438

Shebuski, R. J., Fujita, T., Smith, J. M., Jr.and Ruffolo, R R, Jr.: Comparison

of the alpha adrenoceptor activity ofdopamine, ibopamine and epinine inthe pulmonary circulation ofthe dog,6

Shepherd, J. see Flavahan, N. A., 361Sherman, S. see Ohlstein, E. H., 554Shibuya, M., see Asano, T., 1033

1140 Indsx

Shinyama, H., see Matsumura, Y., 1000Shrikhande, A. V., see Sarmiento, J. G., 140Sinoatnial node cells, electrophysiological

study, cibenzoline (rabbits), 982SK&F 88046 and SK&F 102922, coronary

vasoconstriction, leukotriene D4-in-

duced, inhibition (dogs), 174Skin, absorption, cutaneous first pass me-

tabolism, topical steroids (mice), 482Sladeczek, F., see Cony, R. N., 258Smallwood, R A., see Ching, M. S., 1006Smith, E. F. ifi and Egan, J. W.: Compari-

son of the effects of a thromboxanesynthase inhibitor or prostacydlin incombination with a phosphodiester-see inhibitor for prevention of exper-imental thrombosis and suddendeath in rabbits, 835

Smith, J. M., Jones, S. B., Bylund, D. B.and Jones, A. W.: Characterizationofthe alpha-i adrenergic receptors inthe thoracic aorta of control and al-dosterone hypertensive rats: Come-lation ofmadioligand binding with pa-tassium efflux and contraction, 882

Smith, J. M., Jr., see Shebuski, H. J., 6Smith, J. M., see Jones, S. B., 875Smith, R. P., see Kruszyna, It, 307Smoking

effect on oxidation of theophylline, corti-aol, aging (humans), 488

propranolol metabolism, renal clearanceof metabolites (humans), 928

Sodiumactivation, acetyicholine release, methyl-

mercury (rats), 131proximal and distal tubular effects, dose

dependence, furosemide (rats), 987Sodium channel

antiarrhythmic drugs, use-dependent ef-fects, cardiac Purkinje fibers (dogs),282

block by apnindine, action potential, yen-tricular muscles (guinea pigs), 1065

slowed inactivation, dendrotoxin, Myxi-cola giant axons, 793

Sonnino, P., see Van Inwegen, H. G., 117Spealman, R. D., see Coffin, V. L., 76Spearman, M. E., Goodwin, R M., Apel-

gren, L D. and Bumol, T. F.: Dispo-sition of the monoclonal antibody-

vines alkaloid conjugate KS1/4-DAVLB (LY256787) and free 4-de-sacetylvinblastine in tumor-bearingnude mice, 695

Spiroperidol, acute opiate tolerance, modi-fication of development, dopamine

receptor sensitivity (mice), 48Sniivas, N. R, Quinn, D., Hubbard, J. W.

and Midha, K. K.: Stereoselectivedisposition of methylphenidate inchildren with attention-deficit disor-den, 300

ST-587, alpha adrenoceptor activity (rab-bits, rats, guinea pigs, dogs), 771

Stasaen, F. L, see Kinter, L B., 797Steiness, E., see Christensen, S., 987Stereochemistry, aromatic phenytoin hy-

droxylation, hydroxylation pheno-types (humans), 615

Steroidsstructure-activity relationships for inter-

action, -y-aminobutynic acidA recep-tom complex, 346

topical, skin absorption (mice), 482

Stewart, J., see Lions, I., 608Stomach

gastric excitation, stimulation of vega!trunk, chronic supranodose vagot-omy (cats), 650

WHR1582A, gastric antisecretory and an-tiulcer effects (rats), 97

Stone, C. K., see Imai, N., 20Stone, G. A., see Williams, M., 415Strandhoy, J. W., see Wolff, D. W., 472Strange, P. G., see Williams, K, 939Streptomycin, aminoglycoside-induced neu-

romuscular blockade, potentiation,protons (frogs, rats), 686

Streptozotocin, induced diabetes mellitus,renal handling, netilmicin (rats), 166

Stress, restraint, plasma prolactin response,nicotine (rats), 438

Stniatum, dopamine release from synapto-somes, calcium, modulation (rats), 27

StuB, R. W., see Eisenhofem, G., 547Substantia nigra, alpha-2 adrenoceptors,

anticonvulsant action, muscimol

(rats), 751Sulfinpyrazone, effects on platelet activa-

tion, bronchoconstriction, U46619(humans), 615

Suihydryl reagents, tetraethylammoniumtransport, renal brush border mem-branes (rats), 1010

Summers, R. J., see Molenaar, P., 1041, 1048Sunflower oil, effect of dietary lipids, mo-

tropic responses, atrium (rats), 838Surfactant, adenosine A2 receptor regula-

tion, phosphatidylcholine secretion,pneumocytes (rats), 907

Suzuki, Y., see Asano, T., 1033Sympathectomy, parotid gland, amino acid

uptake (rats), 663

Sympathetic nervous system, role in main-tenance of hypertension, pheochro-mocytoma (rats), 870

Synaptosomesenantiomers of threo-methylphenidate,

pharmacology of (rats), 152free calcium modulation, organochlonine

insecticides (rats), 575Szab#{243},G., see Kovics, G. L, 569

Tachycardia, glucagon and calcium, chron-otropic action (rats), 833

Tai, H. H., see Gillespie, M. N., 812Takami, T., see Kotake, H., 982Takano, M., see Hori, R., 1010Takayasu, M., see Asano, T., 1033Takemoni, A. E., see Martin, J. H., 48Talbot, P. A.: Potentiation of aminoglyco-

side-induced neuromuscular block-ads by protons in vitro and in viuo,686

Tallent, C. R, see Cook, C. E., 779Tamai, I., see Tsuji, A., 594Tariq, M., Parmar, N. S. and Aged, A. M.:

Gastric and duodenal antiulcer andcytoprotective effects of proglumidein rats, 602

Taylor, D. A., see Hawthorn, M. H., 453Tejani-Butt, S., see Conway, P. G., 755Telegdy, G., see KovIcs, G. L, 569Terasaki, T., see Tauji, A., 594Terbutaline, adenosine A2 receptor regula-

tion, phosphatidylcholine secretion,pneumocytes (rats), 907

Testosterone, skin absorption (mice), 482Tetraethylammonium, transport, renal

Vol.241

brush border membranes, sulfliydryl

reagents (rats), 1010Tetrahydrocannabinol

brain opioid receptors, modulation (rats),534

delta-9(11) interactions with delta-9, ag-onistic activity (mice, dogs, mon-keys), 521

Theophyllineadenosine A2 receptor regulation, phos-

phatidylcholine secretion, pneumo-cytes (rats), 907

cortisol and, effect of cimetidine andsmoking, aging (humans), 488

effects, acquisition, conditioned responses(rabbits), 223

neurotoxicity, experimental liver disease(rats), 236

Thiazide, interactions of diuretics, peniph-eral-type benzodiazepine receptor,kidney (rats), 950

Thiolase, hypolipidemic effect, polymethy-lenemethane thiosulfonates (rats),1099

Thompson, K. A., Blair, I. A., Woosley, RL and Roden, D. M.: Comparative invitro electrophysiologjr of quinidine,its major metabolites and dihydro-quinidine, 84

Thrombosis, prevention of, prostacydlin andphosphodiesterase inhibitor (nab-bits), 855

Thromboxanechemotactic peptide stimulation, healthy

and inflamed colons (rabbits), 218U46619-induced bronchoconstriction, ef-

fects of sulfinpyrazone, platelet acti-vation (humans), 623

Thromboxane synthase, inhibitor, phospho-diesterase inhibitor and, thrombosisprevention (rabbits), 855

Thron, C. D., see Kruszyna, R., 307Timolol, effects of adrenergic receptor an-

tagonists, heart, pheochromocytoma

(rats), 354Tolbutamide, hepatic metabolism, methyl

hydroxylation, 1112Tomoike, H., see Adachi, H., i072Tormay, A., see Mittag, T. W., 230Torphy, T. J., see Kopia, G. A., 174Toxicity, acetaminophen-protein adducta,

sensitive immunochemical assay(rabbits), 527

Toyama, J.,see Kodama, I., 1065Trachea, dual effects of Haemophilus influ-

enzae, beta adrenoceptor function(guinea pigs), 994

Triazolodiazepinea, WEB 2086, antagonist,platelet activating factor (humans),974

Triazoloquinazoline, biochemical character-ization, 415

i,1,1-Trichloroethane, stimulus properties,pentobarbital-like (mice), 507

Trifluopenazine, antagonism, calmodulin-stimulated adenylate cyclaae, cere-belier membranes (rats), 407

ephalosporin antibiotic, across brush-bordermembrane vesicles from rat small in-testine, 594

Tsurufuji, S., see Hirasawa, N., 967Tyramine, neurotoxicity, brain technetium-

99m-diethylenetniamine penta-aceticacid (dogs), 42

1987 Index 1141

U46619, induced bronchoconstriction, nal,proglumide, cytoprotective effects

(rats), 602WHR1582A, gastric antisecretory effects

(nats), 97

Uretha, smooth muscle contraction, alpha-1 adrenoceptors, bunazosin (rabbits),1017

Uriu, see Matsumura, Y., 1000

Vega! trunk, gastric excitation, chronic su-pranodose vagotomy (cats), 650

Valocik, R. E., see Kopia, G. A., 174Vanhoutte, P. M., see Flavahan, N. A., 361Vanhoutte, P. M., see Houston, D. A, 501Vanhoutte, P. M., see O’Rourke, S. T., 64Van Inwegen, R G., KhandWala, A., Con-

don, R., Sonnino, P., Coutts, S. andJolly, S.: REV 9501: An orally effec-tive peptidoleukotriene antagonist,

detailed biochemical/pharmacologi.cal profile, 117

van Ree, J. M., see de Wied, D., 268Vargaftig, B. B., see Hatmi, M., 623Vas deferens

bradykinin receptor sites, structural pre-requisites (rats, mice, guinea pigs,hamsters), 608

calcitonin gene-related peptide, inhibi-tory effect, smooth muscle ofvas def-erens (rats), 635

endogenous and exogenous norepineph-nine, dihydroxyphenylglycol, intra-neuronal metabolism (rats), 547

Vasoactive intestinal peptide, intraocularpressure and, ocular ciiary processes,adenylate cyclase activation (nab-bits), 230

Vasoconstriction

coronary, leukotriene D4-induced, leuko-triene antagonists (dogs), 174

pulmonary, alpha adrenoceptors,.compar-ison (dogs), 6

Vasodilation. acetylcholine-induced, role, endotheium-

derived relaxing factor (rabbits), 516cholinergic, endotheium-mediated relax-

ation, effect of age (rats), 387

Vasodilators, effects on presser responses,

alpha adrenocepton agonists (dogs),846

Vasopressinantagonism (monkeys), 797oxytocin and, C-terminal fragments,

avoidance behavior (rats), 268Vasorelaxation, endotheium-dependent,

coronary arteries, magnesium defi-ciency (dogs), 961

Vasospasm, HA1O77, mechanism of action

(rabbits, dogs, guinea pigs), 1033Vaught, J. L., see Porreca, F., 393Vavrek, R.see Uona, I., 608Vaysae, P. J.-J., Gardner, E. L and Zukin,

R. S.: Modulation of rat brain opioidreceptors by cannabinoids, 534

Ventral tegmental area, enkephalin activa-tion, dopamine neurons, mu opioidreceptor (rats), 328

Ventricular fibrillation, dilevalol, receptorblockade, methylacopolamine (dogs),741

VerapamilBay K 8644, characteristics of binding,

cardiac membranes (rabbits), 140enhanced erythropoietin production, cx-

posure to hypoxia (rats), 428nitroglycerin and, coronary and systemic

hemodynamics (dogs), 1072Vesell, E. S., see Fabisiak, J. P., 722, 728Vestal, R. E., Cusack, B. J., Mercer, G. D.,

Dawson, G. W. and Park, B. K.: Ag-ing and drug interactions. I. Effect ofcimetidine and smoking on the oxi-dation oftheophylline and cortisol inhealthy men, 488

Virus, R. see Commins, D. L., 338Vosmer, G., see Commins, D. L., 338

W-7, antagonism, calmodulin-stimulatedadenylate cyclase, cerebellar mem-branes (rats), 407

Wagner, S. R., see Rhinehart, B. L., 915Walle, T., Walls, U. K., Cowart, T. D., Con-

radi, E. C. and Gaffney, T. E.: Selec-tive induction of propranolol metab-olism by smoking Additional effectson renal clearance of metabolites, 928

Walle, U. K., see Walle, T., 928Wang, Y., Kim, M. B. and Palmer, M. R:

Interactions of metaphit with phen-cycidine and sigma agonist actionsin rat cerebellum: Determination ofspecificity and selectivity, 321

Warltier, D. see Wynsen, J. C., 846Wasserman, M. see Kopia, G. A., 174Watanabe, M., see Hirasawa, N., 967Water flow, parathynoid hormone frag-

ments, calcium transport, bladder(toads), 448

WEB 2086, pharmacological actions, antag-onist, platelet activating factor (hu-mans), 974

Weber, K.-H., see Casals-Stenzel, J., 974Weiner, N., see Bowyen, J. F., 27Wheatley, M. see Rhinehart, B. L., 915WHR1582A, gastric antisecretony and an-

tiulcer effects (rats), 97Wick, P. F., Keung, A. C., Bowler, J. J. and

Deth, R. C.: Alpha-i adrenergic cou-pling events induced by full and par-tial agonists in rabbit aorta, 458

Wightman, J. M., Schadt, J. C. and Gaddis,R. R.: Decreased vascular resistanceafter intra-artenial injection of [metjenkephalin in the hindquarters ofconscious rabbits, 314

Wilcox, D. E., see Kruszyna, R., 307Wilkinson, G. see Knodell, R. G., 1112Willey, S. C., see Chernow, B., 833Williams, J. S., Baik, Y. H., Koch, W. J.

and Schwartz, A.: A possible role forthe endothelium in porcine coronarysmooth muscle responses to dihydro-

pynidine calcium channel modula-tore, 379

Williams, K., Bennett, T. and Strange, P.G.: Effects of noradrenergic denen-vation on alpha-i adrenoceptors andreceptor-stimulated contraction ofchick expansor secundarionum mus-dc, 939

Williams, M., Francis, J., Ghai, G., Braun-walden, A., Psychoyos, S., Stone, G.A. and Cash, W. D.: Biochemicalcharacterization of the triazoloquin-

azoline, CGS 15943, a novel, non-xanthine adenosine antagonist, 415

Wills, R. J., Gallo-Torres, H. E., Bentko, R.and Min, B. H.: Pharmacokineticsand antisecretory activity of tnimo-prostil in Heidenhain-pouch dogs,433

Wince, L C., Hugman, L. E., Chen, W. Y.,Robbmns, R. K. and Brenner, G. M.:Effect of dietary lipids on inotropicresponses of isolated rat left atrium:Attenuation of maximal responses byan unsaturated fat diet, 838

Winsky, L. and Harvey, J. A.: Effects of N�-(L-phenylisopropyl)adenosmne, cal-feine, theophylline and rolipram onthe acquisition of conditioned re-spouses in the rabbit, 223

Within, J. M., Alvarado-Garcia, R., Lee, M.A. and Witkin, K. M.: Nonmuscar-inic neurotoxicity of oxotremorine,34�

Witkin, K. M., see Witkin, J. M., 34Wolfe, J., Kreider, M. S., Goodman, C. and

Brunswick, D. J.: Labeling in uwo ofserotonin uptake sites in rat brainafter administration of [3Hjcyanoim-ipramine, 196

Wolff, D. W., Gesek, F. A. and Strandhoy,J. W.: In vivo assessment of rat renalalpha adrenoceptors, 472

Wong, B. see Corcoran, G. B., 921Woolverton, W. L., Kamien, J. B. and Gold-

berg, L I.: Pharmacological analysisof the apomonphine discriminativestimulus in rhesus monkeys, 213

WRK1 cells, serotonin receptor, stimula-tion, inoaltol phosphate formation,258

Yamada, A., see Adachi, H., 1072Yamada, see Kodama, I., 1065Yamamoto, R and Chine, W. H., Jr.: Release

of endogenous NE from the mesen-teric vasculature of WKY Kyoto andSHR in response to PNS, 826

Yang, J. S..J. and Olsen, R W.: ‘,‘-Amino-butyric acid receptor-regulated �C1�

flux in the mouse cortical slices, 677Yang, P.-C., see Papaioannou, S., 91Yang, see Sabatini, S., 448Yasuhara, M., see Ramzan, I. M., 236Yohimbine

alpha-i adrenoceptorsbinding, aortas (dogs), 875thoracic aorta, hypertension (rats), 882

maintenance of hypertension, sympa-thetic nervous system, pheochromo-cytoma (rats), 870

Zaloga, G. P., see Chernow, B., 833Zelis, R. see Dnexlen, H., 13

Zerkowski, H.-R., see Ikezono, K., 294Zimmerman, D. M., Leander, J. D., Reel, J.

K. and Hynes, M. D.: Use of a-fun-altrexamine to determine mu opioidreceptor involvement in the analgesic

activity of various opioid ligands, 374Zipser, R D., Patterson, J. B. and LeDuc,

L. E.: Chemotactic peptidetion ofleukotrienes from healthy andinflamed rabbit colons, 218

Zivkovic, B., see Lloyd, K. G., 245Zivkovic, B., see Scatton, B., 251Zukin, R. S., see Vayasse, P. J.-J., 534