Relating Animal Model Phenotypes to Human Disease Genes Project Goals:
Genetics of Behaviorguralnl/441Genetics of Behavior.pdfGenetics of Behavior •Overview • Animal...
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Genetics of Behavior • Overview • Animal Models • Single genes • Multigenes
Transcript of Genetics of Behaviorguralnl/441Genetics of Behavior.pdfGenetics of Behavior •Overview • Animal...
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Genetics of Behavior
• Overview• Animal Models• Single genes• Multigenes
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Animal Models
• Use model animal• Different strains with
behaviors• Genetic crosses• Transgenic animals
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Transgenic models
Leptin: activates a control in hypothalamus
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Single Genes: Huntington DiseaseNormal mouse brain tissue
Huntington
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Bipolar Mood disorders
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Schizophrenia
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Schizophrenia and relationship
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Blue low gene activity, red high gene activity
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AlzheimersAmyloid beta protein on chromosome 21,
Amygdala Hippocampus
Limbic system: Controls emotions and memory
Emotional stability
Convert stimuli to longTerm memory