General features of insulin signal transduction pathways

Jeong-a Kim, et al. Circulation 2006;113:1888-1904

Insulin-stimulated secretion of ET-1 from vascular endothelial cells is mediated by MAP-kinase (MAPK)-dependent pathways but not PI

3-kinase–dependent pathways

Jeong-a Kim, et al. Circulation 2006;113:1888-1904

Parallel impairment in insulin-signaling pathways under pathological conditions

contributes to synergistic coupling of insulin resistance and endothelial

dysfunction

Jeong-a Kim, et al. Circulation 2006;113:1888-1904

Shared and interacting mechanisms of glucotoxicity, lipotoxicity, and

inflammation

Jeong-a Kim, et al. Circulation 2006;113:1888-1904

Pathway-specific insulin resistance creates imbalance between

prohypertensive and antihypertensive vascular actions

Jeong-a Kim, et al. Circulation 2006;113:1888-1904

Vasodilator actions of insulin and DHEA

mediated by NO are regulated by PI 3-kinase (PI3K)-dependent signaling

pathways

Jeong-a Kim, et al. Circulation 2006;113:1888-1904

In vitro model of metabolic insulin resistance with

compensatory hyperinsulinemia in vascular endothelium

Jeong-a Kim, et al. Circulation 2006;113:1888-1904

Mechanisms for the contribution of insulin resistance to atherosclerosis

Jeong-a Kim, et al. Circulation 2006;113:1888-1904

SHRs serve as a model of the metabolic syndrome

Jeong-a Kim, et al. Circulation 2006;113:1888-1904

Losartan therapy simultaneously improves adiponectin levels (A),

insulin resistance (B), endothelial dysfunction (C), and inflammatory markers (D) in subjects with hypercholesterolemia and hypertension

Jeong-a Kim, et al. Circulation 2006;113:1888-1904QUICKI indicates Quantitative Insulin-Sensitivity Check Index