Gene Regulation in Health in Disease (GRHD) Research Center of Excellence at CSU GRHD Logo is...

Gene Regulation in Health in Disease (GRHD) Research Center of Excellence at CSU

GRHD Logo is “under construction” by CSU Art Department


History of GRHD

GRHD: past, present and future

Why GRHD is a Center/Cluster of Excellence?

GRHD development/future


Center was launched in 2008 with $900,000 funding from the Ohio Third Frontier Commission’s Ohio Research

Scholars Program.

Initiative of the 4 co-founding GRHD members:

Dr. Michael Kalafatis (CHM) Dr. Anton A. Komar (BIO)

Dr. Barsanjit Mazumder (BIO)Dr. Crystal M. Weyman (BIO): co-founding director

Currently brings together 15 faculty from 3 departments:BIO – 9 faculty; CHM – 5 faculty; PHS; 1 faculty


Vision Statement:

To enhance and integrate research focused on Gene Regulation in

Health and Disease leading to better understanding of the molecular

mechanisms controlling these processes and the identification of

therapeutic targets.


Mission Statement:To develop and support research focused on Gene Regulation in Health and Disease.

To encourage and provide support mechanisms for the acquisition of extramural funding.

To encourage and provide support mechanisms for the dissemination of research results.

To create mechanisms to acquire resources to support research and student training focused on Gene Regulation in Health and Disease.

To develop and expand partnerships with relevant public and private community entities with similar interests.

To develop and promote Cleveland State University’s reputation as a local, national and international leader in Gene Regulation in Health and Disease.


External Advisory Committee:Paul DiCorleto, Ph.D.Staff, Institute ChairmanLerner Research Institute, Cleveland Clinic

Richard W. Hanson, Ph.D.Leonard & Jean Skeggs Professor of BiochemistryDepartment of Biochemistry, CWRU School of Medicine

Roy L. Silverstein, M.D.John and Linda Mellowes Professor and Chair, Department of MedicineProfessor of Cell Biology and Physiology, Medical College of Wisconsin

George R. Stark, Ph.D.Distinguished Scientist, Cleveland ClinicMember of the U.S. National Academy of Science and Institute of Medicine and Fellow of the Royal Society of London

Toni Scarpa, Ph.D.Former director of the Center for Scientific Review, NIH


Membership

Criteria:

Non-tenured faculty shall have a strong record of publication in peer-reviewed high impact scientific journals within the preceding five years.

Tenured faculty shall additionally have the following within the preceding five years: (a) served as Principal Investigator on a national grant awarded to CSU and (b) published at least three peer-reviewed scientific manuscripts as a senior and/or corresponding author.


Membership

Requirements:

All members, if not currently funded by a national grant, shall submit at least one national grant per year.

All members shall submit grants for internal review by at least two members of the GRHD executive committee or by one member of the executive committee and one nationally funded/distinguished scientist.

All members are strongly encouraged to submit study section reviews of their grants to the GHRD executive committee for review and additional feedback.

All members shall provide an annual research report to the executive committee detailing grant activity, manuscript submission/publication, invited seminars, poster presentations, service to the profession in the form of grant and manuscript review, and completion of doctoral dissertation, MS thesis and undergraduate independent study.

GRHD faculty

4

6

8

10

12

14

16

18

2007 2008 2009 2010 2011 2012 2013 2014 2015

year

Fa

cult

y

Aimin & Xue-Long

(Crystal, Michael, Barsan, Anton) + (Valentin, Girish, Bibo, Roman)

Sailen

Andy & Bin Aaron & Tony

GRHD faculty

Translational control of gene expression and protein folding.

Anton A. KomarBIO

Blood coagulation and cancer.

Michael KalafatisCHM

Regulation of inflammation.Atherosclerosis.

Barsanjit MazumderBIO

Apoptosis (cell death). Muscular dystrophy and cancer.

Crystal M. WeymanBIO

Planning/Executive Committee

GRHD faculty

Chromosome segregation during meiosis.

G. Valentin BoernerBIO

Telomere (sections of DNA at the ends of chromosomes) function.

Bibo LiBIO

Circadian system regulation, aging.

Roman V. KondratovBIO

mRNA processing and stability in relation to prostate cancer.

Girish ShuklaBIO

GRHD faculty

Interferon and RNase L signaling. Diabetes, cancer.

Aimin ZhouCHM

Cardiopulmonary Innate Immunity. Viral infections.

Sailen BarikBIO

Glycoproteins. Chemistry of portein modifications. Antithrombotics.

Xue-Long SunCHM

Mechanotransduction response in epithelial cells. Biology of cilia.

Andrew ResnickPHS

http://www.csuohio.edu/engagedlearning/

GRHD faculty

Design and development of novel anticancer drugs.

Bin SuCHM

DNA replication, nucleoside analogs, cancer.

Anthony BerdisCHM

Chromosome dynamics,production of normal sperm and eggs.

Aaron F. SeversonBIO

GRHD: awards 2009-2013

$11,837,417 total

Extramural funding, grants:

Private donations:

$1,850,000 total

NIH (R01, R15, R03, R21), NSF, HFSP, AHA, DoD, March of Dimes

Parker Hannifin Co.

GRHD: indirect costs year-by-year

year

0

100,000

200,000

300,000

400,000

500,000

600,000

2007 2008 2009 2010 2011 2012 2013 2014

$

GHRD was entitled to 25%will be 20% starting 2014

GRHD brought to CSU $2,349,689

GRHD: awards 2009-2013

$11,837,417 total

Extramural funding, grants:

Private donations:

$1,850,000 total

NIH (R01, R15, R03, R21), NSF, HFSP, AHA, DoD, March of Dimes

Parker Hannifin Co.

2009-2013From the BLUE RIDGE INSTITUTE for MEDICAL RESEARCH BRIMR.ORG

Rank Name Physiology

1 VANDERBILT UNIVERSITY MED CTR $23,437,997

2 MEDICAL COLLEGE OF WISCONSIN $16,189,505

3 UNIV OF NORTH CAROLINA CHAPEL HILL $15,721,507

4 UNIVERSITY OF PENNSYLVANIA $11,771,169

5 NORTHWESTERN UNIVERSITY AT CHICAGO $11,624,780

6 UNIVERSITY OF MICHIGAN $10,697,104

7 UNIVERSITY OF WASHINGTON $10,619,368

8 UNIVERSITY OF NEVADA RENO $10,049,409

9 NEW YORK UNIVERSITY SCHOOL OF MEDICINE $9,768,189

10 JOHNS HOPKINS UNIVERSITY $9,461,361

11 WAKE FOREST UNIVERSITY HEALTH SCIENCES $9,236,186

12 UNIVERSITY OF VIRGINIA $8,312,060

13 UNIVERSITY OF MARYLAND BALTIMORE $8,158,668

14 UNIVERSITY OF CALIFORNIA SAN FRANCISCO $7,798,185

15 UNIVERSITY OF TENNESSEE HEALTH SCI CTR $7,538,806

16 UNIVERSITY OF CALIFORNIA DAVIS $7,444,029

17 UNIVERSITY OF MISSISSIPPI MEDICAL CENTER $7,232,256

18 WEILL MEDICAL COLL OF CORNELL UNIV $7,217,014

19 UNIVERSITY OF ARIZONA $6,579,578

20 TEMPLE UNIV OF THE COMMONWEALTH $6,268,841

21 OREGON HEALTH & SCIENCE UNIVERSITY $5,950,894

22 UNIVERSITY OF FLORIDA $5,901,429

23 UNIVERSITY OF ILLINOIS $5,861,054

24 UNIVERSITY OF CALIFORNIA LOS ANGELES $5,761,858

25 ALBERT EINSTEIN COLLEGE OF MEDICINE $5,751,384

From the BLUE RIDGE INSTITUTE for MEDICAL RESEARCH BRIMR.ORG

Rank NameAnatomy/Cell

Biology


2 BAYLOR COLLEGE OF MEDICINE $17,498,091

3 HARVARD UNIVERSITY (MEDICAL SCHOOL) $16,729,520

4 VANDERBILT UNIVERSITY MED CTR $16,590,870

5 NEW YORK UNIVERSITY SCHOOL OF MEDICINE $14,738,339

6 STANFORD UNIVERSITY $13,622,582

7 DUKE UNIVERSITY $13,605,292

8 UNIVERSITY OF PITTSBURGH AT PITTSBURGH $11,258,793


10 UNIVERSITY OF MICHIGAN $10,979,313

11 UNIVERSITY OF CALIFORNIA SAN FRANCISCO $10,620,146

12 YALE UNIVERSITY $10,411,038

13 NORTHWESTERN UNIVERSITY AT CHICAGO $10,302,432

14 UNIVERSITY OF CALIFORNIA DAVIS $10,220,074

15 UT SOUTHWESTERN MEDICAL CENTER $9,444,742

16 UNIVERSITY OF ALABAMA AT BIRMINGHAM $9,063,212

17 UNIVERSITY OF ARIZONA $8,508,562

18 WASHINGTON UNIVERSITY $7,055,952

19 UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL $7,038,407

20 UNIVERSITY OF KANSAS $6,936,080


22 UNIVERSITY OF SOUTHERN CALIFORNIA $6,072,959

23 UNIVERSITY OF IOWA $6,065,735


25 UNIVERSITY OF VIRGINIA $5,414,567

2009-2013

From the BLUE RIDGE INSTITUTE for MEDICAL RESEARCH BRIMR.ORG

Rank Name Genetics

1 BAYLOR COLLEGE OF MEDICINE $50,019,610

2 STANFORD UNIVERSITY $27,338,571

3 WASHINGTON UNIVERSITY $23,822,082

4 UNIV OF NORTH CAROLINA CHAPEL HILL $23,304,731


6 HARVARD UNIVERSITY (MEDICAL SCHOOL) $16,119,740

7 UNIVERSITY OF CHICAGO $14,703,865

8 DUKE UNIVERSITY $14,593,805

9 UNIVERSITY OF PITTSBURGH AT PITTSBURGH $14,195,597

10 YALE UNIVERSITY $12,082,529

11 WEILL MEDICAL COLL OF CORNELL UNIV $11,412,947

12 UNIV OF MASSACHUSETTS MED SCH WORCESTER $11,009,262

13 COLUMBIA UNIVERSITY HEALTH SCIENCES $10,246,903

14 EMORY UNIVERSITY $9,771,593

15 MOUNT SINAI SCHOOL OF MEDICINE $9,234,835

16 STATE UNIVERSITY NEW YORK STONY BROOK $8,795,628


18 UNIVERSITY OF FLORIDA $8,102,544


20 CASE WESTERN RESERVE UNIVERSITY $7,550,572


22 UNIVERSITY OF MINNESOTA $7,046,247

23 UNIVERSITY OF MIAMI SCHOOL OF MEDICINE $7,011,350

24 UNIVERSITY OF UTAH $6,921,971

25 UNIVERSITY OF CALIFORNIA LOS ANGELES $6,167,443

2009-2013

GRHD publications/impact factor

Web of Science: The most comprehensive and versatile research platform available

Center University Established

Number of Faculty

Number of papers published in2009-2013

(corresponding from the center; excluding collaborative papers)

Sum of the

times cited

h-index

Center for RNA Biology

The Ohio State University

2007 33 128 1922 22

Center for Eukaryotic Gene

Regulation

Penn State Univ.Huck Institutes of the Life Sciences

2008 8 53 1252 19

Center for RNA* Molecular Biology

CWRU 1997 10-16 79 1274 17

Center for Gene Regulation in

Health and Disease

CSU 2008 15 (started in

2008)

69 743 17

Plant Gene Expression Center

Univ. California Berkeley/USDA

1987 9 55 871 17

Center for Molecular and

Mitochondrial Med and Genetics

University of California, Irvine

2003 50 42 629 14

Center for Molecular Biology

of RNA

University Calif, Santa Cruz

1992 9 59 488 13

Sealy Center for Molecular Medicine

University of Texas Medical

Branch, Galveston

2007 33 93 597 13

Center for Stem Cell Research and Regenerative Med.

Tulane University, New Orleans

2000 16 39 267 10

Center for Molecular

Microbiology

Univ Florida, Gainesville

2000 19 20 272 7

Center University Established Number of Faculty

Number of papers published in2009-2013

Sum of the times cited

h-index

Center for RNA Biology The Ohio State University

2007 33 128 1922 22

Center for Eukaryotic Gene Regulation

Penn State Univ.Huck Institutes of the

Life Sciences

2008 8 53 1252 19

Center for RNA* Molecular Biology

CWRU 1997 16 79 1274 17

Center for Gene Regulation in Health and

Disease

CSU 2008 15 69 743 17

Plant Gene Expression Center

Univ. California Berkeley/USDA

1987 9 55 871 17

Center for Molecular and Mitochondrial Med and

Genetics

University of California, Irvine

2003 50 42 629 14

Center for Molecular Biology of RNA

University Calif, Santa Cruz

1992 9 59 488 13

Sealy Center for Molecular Medicine

University of Texas Medical Branch,

Galveston

2007 33 93 597 13

Center for Stem Cell Research and

Regenerative Med.

Tulane University, New Orleans

2000 16 39 267 10

Center for Catalytic Science and Technology

University of Delaware, Newark

2001 11 27 298 9

The Penn Center for Molecular Discovery

Penn State, Philadelphia

2006 16 20 151 9

Center for Molecular Microbiology

Univ Florida, Gainesville

2000 19 20 272 7

Center for Molecular and Comparative

Endocrinology

University of New Hampshire, Durham

2008 8 26 132 7

Center for Molecular Biology and

Biotechnology

Florida Atlantic University, Jupiter

1999 28 17 51 5

*was ranked first in the nation in NIH funding in the category of Other Basic Sciences in 2004, when compared with peer departments at other medical schools.

GRHD: present and future

GRHD permanent budget (provost funds): $25,000

Will continue to cover: invited speakers, printing costs, equipment emergency repair, etc…

BUDGET:

Indirect costs + 25K permanent budget:

Before 2014: GRHD 25%; PIs 5%

Starting 2014: GRHD 20%; PIs 10%

GRHD 2014 projected indirects: ~$100,000

Covers pilot projects, serves as bridge funding, etc…

GRHD present and future

Research of GRHD faculty: Pilot/innovative projects Bridge funding

GRHD graduate students progress report seminar: Monday 12-1 pm

GRHD distinguished/invited speakers seminar

Apart from aggressive grant submission strategy:

Feb 5th deadline grants submitted:

3X R01s, AHA GiA, NSF (URM training grant; jointly with CWRU)

GRHD is looking for private funding to support:

GRHD present and future

Plans to address

Corporations:

STERIS, FISHER Scientific, AMRESCO, MPI biochemicals...

Foundations:

Ohio 3d Frontier Mt. Sinai Health Care Foundation The Rockefeller Foundation

Short-term goal - to get ~$2M

GRHD: web site will be re-designed

GRHD lab web page

GRHD lab web page

Research interests:

Research interests:

GRHD: web site (will use CC as a model)

Lab members

GRHD: web site

GRHD: logo will be designed by CSU art department

GRHD publicity:

Will be installed in the hallway close to the seminar room SR255

GRHD research news appearing on this display will be synchronized with GRHD research news appearing on GRHD web site

GRHD research has led to 3 start-up companies

GRHD technology transfer

GRHD research has led to 3 start-up companies:

DAPCEL, Inc 2008 (Komar, BIO, co-founder, CSO)www.dapcel.com

Tiberian Biosciences & Pharmaceuticals, LLC 2012(Berdis, CHM, co-founder, CSO)http://www.tiberianbioscienceandpharma.com/

Kalafatis, LLC (name not finalized, in process of registration)(Kalafatis, CHM, co-founder, CSO)

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