Game plan Lecture Antibody- antigen binding Humoral immunity Cellular immunity Clonal selection and...
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Transcript of Game plan Lecture Antibody- antigen binding Humoral immunity Cellular immunity Clonal selection and...
Game plan
Lecture
Antibody- antigen bindingHumoral immunityCellular immunityClonal selection and immuno- logical memory
Lab
Staph, Strep and Enteric Unknowns
Antibodies
Antibodies and antigens
Figure 17.1
Antigens (Ag):
- Protein or large polysaccharide- Can be attached or free from cell- Each antigen contains multiple epitopes that are recognized by…
Antibodies (Ab):
- “Immuno- Globulin” proteins (Ig)- Specific for 1 Ag epitope
Antibody structure
Figure 17.3
Antibody classes
Table 17.1
The two arms of adaptive immunity
Fig 17.18
Humoral immunity: control of freely circulatingpathogens
Figure 17.4 - Overview
T-dependent antigens
T- dependentantigens
Proteins (viruses, bacteria, RBC)and haptens
T-independent vs. T-dependent antigens
T- dependentantigens
Proteins (viruses, bacteria,RBC)and haptens
T- independentantigens
Repeating subunits suchas polysaccharides,lipopolysaccharides,and capsules
Clonal selection
Figure 17.5 - Overview
Clonal selection outcomes
1. Proliferation ofAg-specific B cells and TH cells
2. Differentiation of B cells- Plasma cells- Memory cells
3. Production of Ag-specificIgG and IgM
Clonal selection and immunological memory
RESULTS: Antibody- Antigen Binding
Activation of complementAgglutination
OpsonizationAntibody-dependent
cell-mediated cytotoxicity
Neutralization
Reduces number of infectious units to be dealt with
Coating antigen with antibody enhances phagocytosis
Phagocyte
Bacteria
Causes inflammation andcell lysis
Antibodies attached to target cell cause destruction by macrophages, eosinophils, and
NK cells
Eosinophil
Large target cell (parasite)
Blocks adhesion of bacteria and
viruses to mucosa Bacterium
Virus
Blocks attachment of
toxin
Toxin
Complement
Cellular immunity- control of intracellular pathogens
Antigen presenting cells (APCs): Antigenic fragments of pathogensare presented on specific cells (APCs) using MHC II complexes
- Dendritic cells- Macrophage
Cellular immunity- APCs and TH cells
Helper T cells (TH or CD 4): recognizes APC and presented Ag activates cells related to cell- mediated immunity, macrophages, NK cells, T cells, and humoral response (B cells).
Cellular immunity: infected host cells and CTLs
Infected host cells: self-cells that have been infected with a pathogen (or are tumor cells) that present “endogenous antigens”
Cellular immunity: infected host cells and CTLs
Cytotoxic T cells (TC or CD8): differentiate into cytotoxic T Lymphocytes (CTLs) that destroys target cells on contact
The two arms of adaptive immunity
Fig 17.18
Independent study
1. Review humoral and cellular immunity
2. Prepare for Tuesday’s class:
Look through PowerPoint “Lecture 18” Complete Lecture Assignment “Lecture 18 Pre-quiz” and bring
to class on 4/21 (optional: extra credit) Read through the first 3 pages of handout (i.e. Components of Ethical Questions, The Principles of Bioethics, and Focus on Principles) Be prepared for bioethical discussion on “Vaccination”