Funding: Health Foundation, ESVS

3526 patients

24 countries

95 centres

GALA

Funding: Health Foundation, ESVS

Countries & Centres

AustriaAustralia

BelarusChina

CroatiaCzech

RepublicEstonia

GeorgiaGermany

GreeceHungary

Israel

ItalyLatvia

NetherlandsPoland

PortugalSaudi Arabia

SlovakiaSpain

SwedenTurkey

UKUkraine

Funding: Health Foundation, ESVS

Is it time for a randomized trial of local versus generalanaesthesia for carotid endarterectomy?M. J. Gough, T. A. J. Calvey, A. J. McCleary, S. Whitely, A.Bodenham Leeds, UK

Non-randomized, patients had a free choice of the type of anaesthetic.

LA GAN=89 N=101*

30-day stroke rate 0 (0) 4 (4)Perioperative MI 1 (1) 3 (3)Death 1 (1) 2 (2)*P=0·057 versus LAP=0·046 versus LA for combined stroke/MI

These results reinforce the need for a prospective, randomized trial.

Background

Funding: Health Foundation, ESVS

Eur J Vasc Endovasc Surg 13, 491-499 (1997)Local Versus General Anaesthesia in Carotid Endarterectomy:a Systematic Review of the EvidenceC. Tangkanakul, C. E. Counsell and C. P. WarlowNeurosciences Trials Unit, Department of Clinical Neurosciences, Western General Hospital, Edinburgh, U.K.

Eur J Vasc Endovasc Surg 12, 173-181 (1996)The Differing Effects of Regional and General Anaesthesia onCerebral Metabolism During Carotid Endarterectomy*A.J. McCleary, N. M. Dearden, D. H. Dickson, A. Watson M. J. GoughDepartments of Vascular Surgery and Anaesthetics, The General Infirmary, Leeds, U.K.

Introduction

Funding: Health Foundation, ESVS

What Happened Next?

CPW, MJG

Steering Committee

Protocol

MREC

Trial Co-ordinator

Funding

Pilot: 20 UK Centres

Funding: Health Foundation, ESVS

GALA - continued

• Pilot study completed

• MREC approval for main trial

• Funding: Health Foundation

ESVS

• Centre recruitment:Journal advertsVascular SocietyCharing CrossEuropean Meetings

• Trial Office:Bridget ColamAnne FraserSteff LewisMary PatersonVera SoosayAdam Young

• Trial Steering Committee

• Data Monitoring Committee